Reference on EC 1.14.14.19 - steroid 17alpha-monooxygenase
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Dalla Valle, L.; Ramina, A.; Vianello, S.; Belvedere, P.; Colombo, L.
Kinetic analysis of duodenal and testicular cytochrome P450c17 in the rat
J. Steroid Biochem. Mol. Biol.
58
577-584
1996
Rattus norvegicus
Lynn, W.S.; Brown, R.H.
The conversion of progesterone to androgens by testes
J. Biol. Chem.
232
1015-1030
1958
Cavia porcellus, Rattus norvegicus
Hartmann, R.W.; Ehmer, P.B.; Haidar, S.; Hector, M.; Jose, J.; Klein, C.D.; Seidel, S.B.; Sergejew, T.F.; Wachall, B.G.; Wachter, G.A.; Zhuang, Y.
Inhibition of CYP 17, a new strategy for the treatment of prostata cancer
Arch. Pharm.
335
119-128
2002
Homo sapiens
Haidar, S.; Klein, C.D.; Hartmann, R.W.
Synthesis and evaluation of steroidal hydroxamic acids as inhibitors of P450 17 (1 alpha-hydroxylase/C17-20-lyase)
Arch. Pharm.
334
138-140
2001
Homo sapiens, Rattus norvegicus
Recanatini, M.; Bisi, A.; Cavalli, A.; Belluti, F.; Gobbi, S.; Rampa, A.; Valenti, P.; Palzer, M.; Palusczak, A.; Hartmann, R.W.
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17alpha-hydroxylase/C17,20-lyase
J. Med. Chem.
44
672-680
2001
Homo sapiens
Hartmann, R.W.; Hector, M.; Haidar, S.; Ehmer, P.B.; Reichert, W.; Jose, J.
Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17alpha-hydroxylase/C17-20-lyase) and 5alpha-reductase types 1 and 2
J. Med. Chem.
43
4266-4277
2000
Homo sapiens, Rattus norvegicus
Njar, V.C.; Brodie, A.M.
Inhibitors of 17alpha-hydroxylase/17,20-lyase (CYP17): potential agents for the treatment of prostate cancer
Curr. Pharm. Des.
5
163-180
1999
Macacine alphaherpesvirus 1, Homo sapiens, Rattus norvegicus, Sus scrofa
Auchus, R.J.; Miller, W.L.
Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations
Mol. Endocrinol.
13
1169-1182
1999
Homo sapiens (P05093), Homo sapiens
Brock, B.J.; Waterman, M.R.
The use of random chimeragenesis to study structure/function properties of rat and human P450c17
Arch. Biochem. Biophys.
373
401-408
2000
Homo sapiens, Rattus norvegicus
Njar, V.C.; Kato, K.; Nnane, I.P.; Grigoryev, D.N.; Long, B.J.; Brodie, A.M.
Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17alpha-hydroxylase-C17,20-lyase (P450(17)alpha): potential agents for the treatment of prostate cancer
J. Med. Chem.
41
902-912
1998
Homo sapiens, Rattus norvegicus
Bahshwan, S.A.; Owen, C.P.; Nicholls, P.J.; Smith, H.J.; Ahmadi, M.
Some 1-[(benzofuran-2-yl)methyl]imidazoles as inhibitors of 17alpha-hydroxylase: 17,20-lyase (P450 17) and their specificity patterns
J. Pharm. Pharmacol.
50
1109-1116
1998
Bos taurus, Homo sapiens
Beaudoin, C.; Lavallee, B.; Tremblay, Y.; Hu, D.W.; Breton, R.; De Launoit, Y.; Belanger, A.
Modulation of 17alpha-hydroxylase/17,20-lyase activity of guinea pig cytochrome P450c17 by site-directed mutagenesis
DNA Cell Biol.
17
707-715
1998
Cavia porcellus, Homo sapiens
Zhuang, Y.; Zapp, J.; Hartmann, R.W.
Synthesis of Z- and E-1-methyl-2-(1-hydroximinoethyl)-6-methoxy-3,4-dihydronaphthalene and evaluation as inhibitors of 17alpha-hydroxylase-C17,20-lyase (P450 17)
Arch. Pharm.
330
359-361
1997
Homo sapiens
Njar, V.C.; Klus, G.T.; Johnson, H.H.; Brodie, A.M.
Synthesis of novel 21-trifluoropregnane steroids: inhibitors of 17alpha-hydroxylase/17,20-lyase (17alpha-lyase)
Steroids
62
468-473
1997
Rattus norvegicus
Cloutier, M.; Fleury, A.; Courtemanche, J.; Ducharme, L.; Mason, J.I.; Lehoux, J.G.
Characterization of the adrenal cytochrome P450C17 in the hamster, a small animal model for the study of adrenal dehydroepiandrosterone biosynthesis
DNA Cell Biol.
16
357-368
1997
Mesocricetus auratus
Chan, F.C.; Potter, G.A.; Barrie, S.E.; Haynes, B.P.; Rowlands, M.G.; Houghton, J.; Jarman, M.
3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17alpha) (17alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer
J. Med. Chem.
39
3319-3323
1996
Homo sapiens
Fournet, N.; Weitsman, S.R.; Zachow, R.J.; Magoffin, D.A.
Transforming growth factor-beta inhibits ovarian 17alpha-hydroxylase activity by a direct noncompetitive mechanism
Endocrinology
137
166-174
1996
Rattus norvegicus
Potter, G.A.; Barrie, S.E.; Jarman, M.; Rowlands, M.G.
Novel steroidal inhibitors of human cytochrome P45017alpha (17alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer
J. Med. Chem.
38
2463-2471
1995
Homo sapiens
Imai, T.; Globerman, H.; Gertner, J.M.; Kagawa, N.; Waterman, M.R.
Expression and purification of functional human 17alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17alpha-hydroxylase/17,20-lyase deficiency
J. Biol. Chem.
268
19681-19689
1993
Homo sapiens
Bicikova, M.; Hampl, R.; Hill, M.; Starka, L.
Inhibition of steroid 17alpha-hydroxylase and C17,20-lyase in the human testis by epitestosterone
J. Steroid Biochem. Mol. Biol.
46
515-518
1993
Homo sapiens
Kuwada, M.; Sone, Y.; Kitajima, R.
Purification from adult pig testicular P-450 and 17alpha-hydroxylase activity of P-450 containing liposomal membranes
Biochem. Biophys. Res. Commun.
196
816-824
1993
Sus scrofa
Sakaki, T.; Shibata, M.; Yabusaki, Y.; Murakami, H.; Ohkawa, H.
Genetically engineered P450 monooxygenases: construction of bovine P450c17/yeast reductase fused enzymes
DNA Cell Biol.
9
27-36
1990
Bos taurus
Angelastro, M.R.; Laughlin, M.E.; Schatzman, G.L.; Bey, P.; Blohm, T.R.
17beta-(Cyclopropylamino)-androst-5-en-3 beta-ol, a selective mechanism-based inhibitor of cytochrome P450(17alpha) (steroid 17alpha-hydroxylase/C17-20 lyase)
Biochem. Biophys. Res. Commun.
162
1571-1577
1989
Homo sapiens
Schatzman, G.L.; Laughlin, M.E.; Blohm, T.R.
A normal phase high-performance liquid chromatography system for steroid 17alpha-hydroxylase/C17-20 lyase (cytochrome P-45021scc) assays
Anal. Biochem.
175
219-226
1988
Homo sapiens, Rattus norvegicus
Sheets, J.J.; Zuber, M.X.; McCarthy, J.L.; Vickery, L.E.; Waterman, M.R.
Discriminatory inhibition of adrenocortical 17alpha-hydroxylase activity by inhibitors of cholesterol side chain cleavage cytochrome P-450
Arch. Biochem. Biophys.
242
297-305
1985
Bos taurus
Shinzawa, K.; Kominami, S.; Takemori, S.
Studies on cytochrome P-450 (P-450 17alpha,lyase) from guinea pig adrenal microsomes. Dual function of a single enzyme and effect of cytochrome b5
Biochim. Biophys. Acta
833
151-160
1985
Cavia porcellus
Nakajin, S.; Shinoda, M.; Haniu, M.; Shively, J.E.; Hall, P.F.
C21 steroid side chain cleavage enzyme from porcine adrenal microsomes. Purification and characterization of the 17alpha-hydroxylase/C17,20-lyase cytochrome P-450
J. Biol. Chem.
259
3971-3976
1984
Sus scrofa
Nakajin, S.; Shinoda, M.; Hall, P.F.
Purification and properties of 17alpha-hydroxylase from microsomes of pig adrenal: a second C21 side-chain cleavage system
Biochem. Biophys. Res. Commun.
111
512-517
1983
Sus scrofa
Nakajin, S.; Shively, J.E.; Yuan, P.M.; Hall, P.F.
Microsomal cytochrome P-450 from neonatal pig testis: two enzymatic activities (17alpha-hydroxylase and c17,20-lyase) associated with one protein
Biochemistry
20
4037-4042
1981
Sus scrofa
Nakajin, S.; Hall, P.F.
Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of A C21 steroid side-chain cleavage system (17alpha-hydroxylase-C17,20 lyase)
J. Biol. Chem.
256
3871-3876
1981
Sus scrofa
Fevold, H.R.; Wilson, P.L.; Slanina, S.M.
ACTH-stimulated rabbit adrenal 17alpha-hydroxylase. Kinetic properties and a comparison with those of 3beta-hydroxysteroid dehydrogenase
J. Steroid Biochem.
9
1033-1041
1978
Oryctolagus cuniculus
Fan, D.F.; Oshima, H.; Troen, B.R.; Troen, P.
Studies of the human testis. IV. Testicular 20alpha-hydroxysteroid dehydrogenase and steroid 17alpha-hydroxylase
Biochim. Biophys. Acta
360
88-99
1974
Homo sapiens
Namiki, M.; Kitamura, M.; Buczko, E.; Dufau, M.L.
Rat testis P-45017alpha cDNA: the deduced amino acid sequence, expression and secondary structural configuration
Biochem. Biophys. Res. Commun.
157
705-712
1988
Rattus norvegicus
Gupta, M.K.; Guryev, O.L.; Auchus, R.J.
5alpha-reduced C21 steroids are substrates for human cytochrome P450c17
Arch. Biochem. Biophys.
418
151-160
2003
Homo sapiens
Gilep, A.A.; Estabrook, R.W.; Usanov, S.A.
Chimerogenesis in estimation of specificity and pathway directions for cytochrome P45017alpha catalyzed reactions
Biochemistry (Moscow)
69
364-375
2004
Cavia porcellus (Q64410)
Liu, Y.; Yao, Z.X.; Papadopoulos, V.
Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells
Mol. Endocrinol.
19
1918-1931
2005
Mus musculus
Naffin-Olivos, J.L.; Auchus, R.J.
Human cytochrome b5 requires residues E48 and E49 to stimulate the 17,20-lyase activity of cytochrome P450c17
Biochemistry
45
755-762
2006
Homo sapiens
Owen, C.P.; Dhanani, S.; Patel, C.H.; Shahid, I.; Ahmed, S.
Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha))
Bioorg. Med. Chem. Lett.
16
4011-4015
2006
Rattus norvegicus
Patel, C.H.; Dhanani, S.; Owen, C.P.; Ahmed, S.
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha))
Bioorg. Med. Chem. Lett.
16
4752-4756
2006
Rattus norvegicus
Flueck, C.E.; Yaworsky, D.C.; Miller, W.L.
Effects of anticonvulsants on human p450c17 (17alpha-hydroxylase/17,20 lyase) and 3beta-hydroxysteroid dehydrogenase type 2
Epilepsia
46
444-448
2005
Homo sapiens
Taniguchi, F.; Couse, J.F.; Rodriguez, K.F.; Emmen, J.M.; Poirier, D.; Korach, K.S.
Estrogen receptor-alpha mediates an intraovarian negative feedback loop on thecal cell steroidogenesis via modulation of Cyp17a1 (cytochrome P450, steroid 17alpha-hydroxylase/17,20 lyase) expression
FASEB J.
21
586-595
2007
Mus musculus
Souter, I.; Munir, I.; Mallick, P.; Weitsman, S.R.; Geller, D.H.; Magoffin, D.A.
Mutagenesis of putative serine-threonine phosphorylation sites proximal to Arg255 of human cytochrome P450c17 does not selectively promote its 17,20-lyase activity
Fertil. Steril.
85 Suppl 1
1290-1299
2006
Homo sapiens
Brooke, A.M.; Taylor, N.F.; Shepherd, J.H.; Gore, M.E.; Ahmad, T.; Lin, L.; Rumsby, G.; Papari-Zareei, M.; Auchus, R.J.; Achermann, J.C.; Monson, J.P.
A novel point mutation in P450c17 (CYP17) causing combined 17alpha-hydroxylase/17,20-lyase deficiency
J. Clin. Endocrinol. Metab.
91
2428-2431
2006
Homo sapiens
Do Rego, J.L.; Tremblay, Y.; Luu-The, V.; Repetto, E.; Castel, H.; Vallarino, M.; Belanger, A.; Pelletier, G.; Vaudry, H.
Immunohistochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17alpha-hydroxylase/C17, 20-lyase (P450C17) in the frog brain and pituitary
J. Neurochem.
100
251-268
2007
Pelophylax lessonae
Lee, L.S.; Shu, W.J.; Wu, C.M.; Hsieh, C.H.; Chen, S.M.; Hu, C.J.; Chen, W.Y.; Chung, B.C.
A novel compound heterozygous mutation of K494_V495 deletion plus R496L and D487_F489 deletion in extreme C-terminus of cytochrome P450c17 causes 17alpha-hydroxylase deficiency
Mol. Cell. Endocrinol.
249
16-20
2006
Homo sapiens
Kolar, N.W.; Swart, A.C.; Mason, J.I.; Swart, P.
Functional expression and characterisation of human cytochrome P45017alpha in Pichia pastoris
J. Biotechnol.
129
635-644
2007
Homo sapiens
Pechurskaya, T.A.; Lukashevich, O.P.; Gilep, A.A.; Usanov, S.A.
Engineering, expression, and purification of "soluble" human cytochrome P45017alpha and its functional characterization
Biochemistry (Moscow)
73
806-811
2008
Homo sapiens
Shet, M.S.; Fisher, C.W.; Tremblay, Y.; Belanger, A.; Conley, A.J.; Mason, J.I.; Estabrook, R.W.
Comparison of the 17 alpha-hydroxylase/C17,20-lyase activities of porcine, guinea pig and bovine P450c17 using purified recombinant fusion proteins containing P450c17 linked to NADPH-P450 reductase
Drug Metab. Rev.
39
289-307
2007
Bos taurus, Cavia porcellus, Sus scrofa
Tiosano, D.; Knopf, C.; Koren, I.; Levanon, N.; Hartmann, M.F.; Hochberg, Z.; Wudy, S.A.
Metabolic evidence for impaired 17alpha-hydroxylase activity in a kindred bearing the E305G mutation for isolate 17,20-lyase activity
Eur. J. Endocrinol.
158
385-392
2008
Homo sapiens
Beshay, V.E.; Havelock, J.C.; Sirianni, R.; Ye, P.; Suzuki, T.; Rainey, W.E.; Carr, B.R.
The mechanism for protein kinase C inhibition of androgen production and 17alpha-hydroxylase expression in a theca cell tumor model
J. Clin. Endocrinol. Metab.
92
4802-4809
2007
Homo sapiens
Owen, C.P.; Shahid, I.; Olusanjo, M.S.; Patel, C.H.; Dhanani, S.; Ahmed, S.
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha))
J. Steroid Biochem. Mol. Biol.
111
117-127
2008
Rattus norvegicus
Pattison, J.C.; Saltzman, W.; Abbott, D.H.; Hogan, B.K.; Nguyen, A.D.; Husen, B.; Einspanier, A.; Conley, A.J.; Bird, I.M.
Gender and gonadal status differences in zona reticularis expression in marmoset monkey adrenals: Cytochrome b5 localization with respect to cytochrome P450 17,20-lyase activity
Mol. Cell. Endocrinol.
265-266
93-101
2007
Homo sapiens, Rattus norvegicus
Hu, Q.; Negri, M.; Jahn-Hoffmann, K.; Zhuang, Y.; Olgen, S.; Bartels, M.; Mueller-Vieira, U.; Lauterbach, T.; Hartmann, R.W.
Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge
Bioorg. Med. Chem.
16
7715-7727
2008
Homo sapiens
Du, J.; Liang, X.; Zeng, H.; Shu, Y.; Yao, S.; Zhu, B.; Zhuang, G.
Effect of small interfering RNAs of cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) on androgen biosynthesis in theca cells
Cell Biol. Int.
32
469-472
2008
Homo sapiens
Tian, Q.; Zhang, Y.; Lu, Z.
Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases
Gynecol. Endocrinol.
24
362-367
2008
Homo sapiens
Bruno, R.D.; Gover, T.D.; Burger, A.M.; Brodie, A.M.; Njar, V.C.
17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response
Mol. Cancer Ther.
7
2828-2836
2008
Homo sapiens
Shackleton, C.H.; Neres, M.S.; Hughes, B.A.; Stewart, P.M.; Kater, C.E.
17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites
Steroids
73
652-656
2008
Homo sapiens
Pinto-Bazurco Mendieta, M.; Negri, M.; Hu, Q.; Hille, U.; Jagusch, C.; Jahn-Hoffmann, K.; Mueller-Vieira, U.; Schmidt, D.; Lauterbach, T.; Hartmann, R.
CYP17 inhibitors. Annulations of additional rings in methylene imidazole substituted biphenyls: Synthesis, biological evaluation and molecular modelling
Arch. Pharm.
341
547-609
2008
Homo sapiens
Ahmed, S.; Shahid, I.; Dhanani, S.; Owen, C.P.
Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha))
Bioorg. Med. Chem. Lett.
19
4698-4701
2009
Homo sapiens
Turan, S.; Bereket, A.; Guran, T.; Akcay, T.; Papari-Zareei, M.; Auchus, R.J.
Puberty in a case with novel 17-hydroxylase mutation and the putative role of estrogen in development of pubic hair
Eur. J. Endocrinol.
160
325-330
2009
Homo sapiens
Hille, U.E.; Hu, Q.; Vock, C.; Negri, M.; Bartels, M.; Mueller-Vieira, U.; Lauterbach, T.; Hartmann, R.W.
Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls
Eur. J. Med. Chem.
44
2765-2775
2009
Homo sapiens
Chen, C.F.; Wen, H.S.; Wang, Z.P.; He, F.; Zhang, J.R.; Chen, X.Y.; Jin, G.X.; Shi, B.; Shi, D.; Yang, Y.P.; Li, J.F.; Qi, B.X.; Li, N.
Cloning and expression of P450c17-I (17alpha-hydroxylase/17,20-lyase) in brain and ovary during gonad development in Cynoglossus semilaevis
Fish Physiol. Biochem.
36
1001-1012
2010
Cynoglossus semilaevis (B2D2I4)
Dhir, V.; Reisch, N.; Bleicken, C.M.; Lebl, J.; Kamrath, C.; Schwarz, H.P.; Groetzinger, J.; Sippell, W.G.; Riepe, F.G.; Arlt, W.; Krone, N.
Steroid 17alpha-hydroxylase deficiency: functional characterization of four mutations (A174E, V178D, R440C, L465P) in the CYP17A1 gene
J. Clin. Endocrinol. Metab.
94
3058-3064
2009
Homo sapiens
Pinto-Bazurco Mendieta, M.A.; Negri, M.; Jagusch, C.; Mueller-Vieira, U.; Lauterbach, T.; Hartmann, R.W.
Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer
J. Med. Chem.
51
5009-5018
2008
Homo sapiens
Ogishima, T.; Mitani, F.; Suematsu, M.
Cytochrome P-450(17alpha) in beta-cells of rat pancreas and its local steroidogenesis
J. Steroid Biochem. Mol. Biol.
111
80-86
2008
Rattus norvegicus
Sakurai, N.; Maruo, K.; Haraguchi, S.; Uno, Y.; Oshima, Y.; Tsutsui, K.; Matsuda, Y.; Do Rego, J.L.; Pelletier, G.; Vaudry, H.; Nakamura, M.
Immunohistochemical detection and biological activities of CYP17 (P450c17) in the indifferent gonad of the frog Rana rugosa
J. Steroid Biochem. Mol. Biol.
112
5-12
2008
Glandirana rugosa (A6P663)
Sreenivasulu, G.; Senthilkumaran, B.
A role for cytochrome P450 17alpha-hydroxylase/c17-20 lyase during shift in steroidogenesis occurring in ovarian follicles prior to oocyte maturation
J. Steroid Biochem. Mol. Biol.
115
77-85
2009
Clarias gariepinus (C7B608), Clarias gariepinus
Katsumata, N.; Ogawa, E.; Fujiwara, I.; Fujikura, K.
Novel CYP17A1 mutation in a Japanese patient with combined 17alpha-hydroxylase/17,20-lyase deficiency
Metab. Clin. Exp.
59
275-278
2009
Homo sapiens
Li, Y.; Liang, X.; Wei, L.; Xiong, Y.; Yang, X.; Shi, H.; Yang, Z.
Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo
Reprod. Biol. Endocrinol.
7
73-80
2009
Rattus norvegicus
Ivanyi, Z.; Woelfling, J.; Goerbe, T.; Szecsi, M.; Wittmann, T.; Schneider, G.
Synthesis of regioisomeric 17beta-N-phenylpyrazolyl steroid derivatives and their inhibitory effect on 17alpha-hydroxylase/C(17,20)-lyase
Steroids
75
450-456
2010
Rattus norvegicus
Owen, C.P.; Shahid, I.; Lee, W.Y.; Ahmed, S.
Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes
Bioorg. Med. Chem. Lett.
20
5345-5348
2010
Rattus norvegicus
Kaku, T.; Matsunaga, N.; Ojida, A.; Tanaka, T.; Hara, T.; Yamaoka, M.; Kusaka, M.; Tasaka, A.
17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors
Bioorg. Med. Chem.
19
1751-1770
2011
Homo sapiens, Rattus norvegicus
Kaku, T.; Tsujimoto, S.; Matsunaga, N.; Tanaka, T.; Hara, T.; Yamaoka, M.; Kusaka, M.; Tasaka, A.
17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors
Bioorg. Med. Chem.
19
2428-2442
2011
Homo sapiens, Rattus norvegicus
Stefanachi, A.; Favia, A.; Nicolotti, O.; Leonetti, F.; Pisani, L.; Catto, M.; Zimmer, C.; Hartmann, R.; Carotti, A.
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-alpha-hydroxylase/C17-20 lyase
J. Med. Chem.
54
1613-1625
2011
Homo sapiens
Manca, P.; Mulliri, G.; Burrai, G.P.; Pirino, S.; Mameli, O.
Immunohistochemical localisation and molecular expression of the steroidogenic enzyme cytochrome p450 17alpha-hydroxylase/c(17,20)-lyase in the vestibular nuclei of adult male rats
J. Neuroendocrinol.
23
444-449
2011
Rattus norvegicus, Rattus norvegicus Wistar
Swart, A.C.; Storbeck, K.H.; Swart, P.
A single amino acid residue, Ala 105, confers 16alpha-hydroxylase activity to human cytochrome P450 17alpha-hydroxylase/17,20 lyase
J. Steroid Biochem. Mol. Biol.
119
112-120
2010
Capra hircus (A5HEW0), Capra hircus, Homo sapiens (P05093), Homo sapiens, Sus scrofa (P19100), Sus scrofa, Papio ursinus (Q9GLD2), Capra hircus South African angora (A5HEW0)
Akhtar, M.; Wright, J.N.; Lee-Robichaud, P.
A review of mechanistic studies on aromatase (CYP19) and 17alpha-hydroxylase-17,20-lyase (CYP17)
J. Steroid Biochem. Mol. Biol.
125
2-12
2010
Homo sapiens
Chen, Y.; Saini, S.; Zaman, M.S.; Hirata, H.; Shahryari, V.; Deng, G.; Dahiya, R.
Cytochrome P450 17 (CYP17) is involved in endometrial cancinogenesis through apoptosis and invasion pathways
Mol. Carcinog.
50
16-23
2011
Homo sapiens
Khatri, Y.; Gregory, M.C.; Grinkova, Y.V.; Denisov, I.G.; Sligar, S.G.
Active site proton delivery and the lyase activity of human CYP17A1
Biochem. Biophys. Res. Commun.
443
179-184
2014
Homo sapiens (P05093)
Sushko, T.A.; Gilep, A.A.; Usanov, S.A.
Mechanism of intermolecular interactions of microsomal cytochrome P450s CYP17 and CYP21 involved in steroid hormone biosynthesis
Biochemistry (Moscow)
77
585-592
2012
Homo sapiens (P05093)
Yoshimoto, F.K.; Zhou, Y.; Peng, H.M.; Stidd, D.; Yoshimoto, J.A.; Sharma, K.K.; Matthew, S.; Auchus, R.J.
Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates
Biochemistry
51
7064-7077
2012
Homo sapiens (P05093)
Schonemann, M.D.; Muench, M.O.; Tee, M.K.; Miller, W.L.; Mellon, S.H.
Expression of P450c17 in the human fetal nervous system
Endocrinology
153
2494-2505
2012
Homo sapiens
Jin, G.X.; Wen, H.S.; He, F.; Li, J.F.; Chen, C.F.; Zhang, J.R.; Chen, X.Y.; Shi, B.; Shi, D.; Yang, Y.P.; Qi, B.X.; Li, N.
Molecular cloning, characterization expression of P450c17-I and P450c17-II and their functions analysis during the reproductive cycle in males of barfin flounder (Verasper moseri)
Fish Physiol. Biochem.
38
807-817
2012
Verasper moseri (B3VLB1), Verasper moseri (B6UPD2)
Mu, W.J.; Wen, H.S.; He, F.; Li, J.F.; Liu, M.; Ma, R.Q.; Zhang, Y.Q.; Hu, J.; Qi, B.X.
Cloning and expression analysis of the cytochrome P450c17s enzymes during the reproductive cycle in ovoviviparous Korean rockfish (Sebastes schlegeli)
Gene
512
444-449
2013
Sebastes schlegelii
Hough, D.; Cloete, S.W.; Storbeck, K.; Swart, A.C.; Swart, P.
Cortisol production in sheep is influenced by the functional expression of two cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) isoforms
J. Anim. Sci.
91
1193-1206
2013
Ovis aries (Q29497)
Estrada, D.F.; Laurence, J.S.; Scott, E.E.
Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR
J. Biol. Chem.
288
17008-17018
2013
Homo sapiens (P05093)
Tee, M.K.; Miller, W.L.
Phosphorylation of human cytochrome P450c17 by p38alpha selectively increases 17,20 lyase activity and androgen biosynthesis
J. Biol. Chem.
288
23903-23913
2013
Homo sapiens (P05093)
Yoshimoto, F.K.; Desilets, M.C.; Auchus, R.J.
Synthesis of halogenated pregnanes, mechanistic probes of steroid hydroxylases CYP17A1 and CYP21A2
J. Steroid Biochem. Mol. Biol.
128
38-50
2012
Homo sapiens (P05093)
Szabo, N.; Ajdukovic, J.J.; Djurendic, E.A.; Sakac, M.N.; Ignath, I.; Gardi, J.; Mahmoud, G.; Klisuric, O.R.; Jovanovic-Santa, S.; Penov Gasi, K.M.; Szecsi, M.
Determination of 17alpha-hydroxylase-C17,20-lyase (P45017alpha) enzyme activities and their inhibition by selected steroidal picolyl and picolinylidene compounds
Acta Biol. Hung.
66
41-51
2015
Rattus norvegicus
Cui, Y.L.; Xue, Q.; Zheng, Q.C.; Zhang, J.L.; Kong, C.P.; Fan, J.R.; Zhang, H.X.
Structural features and dynamic investigations of the membrane-bound cytochrome P450 17A1
Biochim. Biophys. Acta
1848
2013-2021
2015
Homo sapiens (P05093)
Estrada, D.F.; Skinner, A.L.; Laurence, J.S.; Scott, E.E.
Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5
J. Biol. Chem.
289
14310-14320
2014
Homo sapiens (P05093), Homo sapiens
Petrunak, E.M.; DeVore, N.M.; Porubsky, P.R.; Scott, E.E.
Structures of human steroidogenic cytochrome P450 17A1 with substrates
J. Biol. Chem.
289
32952-32964
2014
Homo sapiens (P05093), Homo sapiens
Peng, H.M.; Liu, J.; Forsberg, S.E.; Tran, H.T.; Anderson, S.M.; Auchus, R.J.
Catalytically relevant electrostatic interactions of cytochrome P450c17 (CYP17A1) and cytochrome b5
J. Biol. Chem.
289
33838-33849
2014
Homo sapiens (P05093)
Pallan, P.S.; Nagy, L.D.; Lei, L.; Gonzalez, E.; Kramlinger, V.M.; Azumaya, C.M.; Wawrzak, Z.; Waterman, M.R.; Guengerich, F.P.; Egli, M.
Structural and kinetic basis of steroid 17?,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2
J. Biol. Chem.
290
3248-3268
2015
Danio rerio (A7U483), Danio rerio (B3DH80), Danio rerio
Oskarsson, A.; Spatafora, C.; Tringali, C.; Andersson, A.O.
Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs
Prostate
74
839-851
2014
Homo sapiens (P05093)
Al-Masoudi, N.A.; Mahdi, K.M.; Abdul-Rida, N.A.; Saeed, B.A.; Engel, M.
A new pregnenolone analogues as privileged scaffolds in inhibition of CYP17 hydroxylase enzyme. Synthesis and in silico molecular docking study
Steroids
100
52-59
2015
Homo sapiens
Ackermann, D.; Pruijm, M.; Ponte, B.; Guessous, I.; Ehret, G.; Escher, G.; Dick, B.; Al-Alwan, H.; Vuistiner, P.; Paccaud, F.; Burnier, M.; Pechere-Bertschi, A.; Martin, P.Y.; Vogt, B.; Mohaupt, M.; Bochud, M.
CYP17A1 enzyme activity is linked to ambulatory blood pressure in a family-based population study
Am. J. Hypertens.
29
484-493
2016
Homo sapiens (P05093)
Yoshimoto, F.K.; Peng, H.M.; Zhang, H.; Anderson, S.M.; Auchus, R.J.
Epoxidation activities of human cytochromes P450c17 and P450c21
Biochemistry
53
7531-7540
2014
Homo sapiens (P05093), Homo sapiens
Gonzalez, E.; Guengerich, F.P.
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1
J. Biol. Chem.
292
13168-13185
2017
Homo sapiens (P05093)
Capper, C.P.; Liu, J.; McIntosh, L.R.; Larios, J.M.; Johnson, M.D.; Hollenberg, P.F.; Osawa, Y.; Auchus, R.J.; Rae, J.M.
Functional characterization of the G162R and D216H genetic variants of human CYP17A1
J. Steroid Biochem. Mol. Biol.
178
159-166
2017
Homo sapiens (P05093)
Simonov, A.N.; Holien, J.K.; Yeung, J.C.; Nguyen, A.D.; Corbin, C.J.; Zheng, J.; Kuznetsov, V.L.; Auchus, R.J.; Conley, A.J.; Bond, A.M.; Parker, M.W.; Rodgers, R.J.; Martin, L.L.
Mechanistic scrutiny identifies a kinetic role for cytochrome b5 regulation of human cytochrome P450c17 (CYP17A1, P450 17A1)
PLoS ONE
10
e0141252
2015
Homo sapiens (P05093)
Kostin, V.A.; Zolottsev, V.A.; Kuzikov, A.V.; Masamrekh, R.A.; Shumyantseva, V.V.; Veselovsky, A.V.; Stulov, S.V.; Novikov, R.A.; Timofeev, V.P.; Misharin, A.Y.
Oxazolinyl derivatives of [17(20)E]-21-norpregnene differing in the structure of A and B rings. Facile synthesis and inhibition of CYP17A1 catalytic activity
Steroids
115
114-122
2016
Homo sapiens (P05093)
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