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Reference on EC 1.14.14.19 - steroid 17alpha-monooxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dalla Valle, L.; Ramina, A.; Vianello, S.; Belvedere, P.; Colombo, L.
Kinetic analysis of duodenal and testicular cytochrome P450c17 in the rat
J. Steroid Biochem. Mol. Biol.
58
577-584
1996
Rattus norvegicus
Manually annotated by BRENDA team
Lynn, W.S.; Brown, R.H.
The conversion of progesterone to androgens by testes
J. Biol. Chem.
232
1015-1030
1958
Cavia porcellus, Rattus norvegicus
Manually annotated by BRENDA team
Hartmann, R.W.; Ehmer, P.B.; Haidar, S.; Hector, M.; Jose, J.; Klein, C.D.; Seidel, S.B.; Sergejew, T.F.; Wachall, B.G.; Wachter, G.A.; Zhuang, Y.
Inhibition of CYP 17, a new strategy for the treatment of prostata cancer
Arch. Pharm.
335
119-128
2002
Homo sapiens
Manually annotated by BRENDA team
Haidar, S.; Klein, C.D.; Hartmann, R.W.
Synthesis and evaluation of steroidal hydroxamic acids as inhibitors of P450 17 (1 alpha-hydroxylase/C17-20-lyase)
Arch. Pharm.
334
138-140
2001
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Recanatini, M.; Bisi, A.; Cavalli, A.; Belluti, F.; Gobbi, S.; Rampa, A.; Valenti, P.; Palzer, M.; Palusczak, A.; Hartmann, R.W.
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17alpha-hydroxylase/C17,20-lyase
J. Med. Chem.
44
672-680
2001
Homo sapiens
Manually annotated by BRENDA team
Hartmann, R.W.; Hector, M.; Haidar, S.; Ehmer, P.B.; Reichert, W.; Jose, J.
Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17alpha-hydroxylase/C17-20-lyase) and 5alpha-reductase types 1 and 2
J. Med. Chem.
43
4266-4277
2000
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Njar, V.C.; Brodie, A.M.
Inhibitors of 17alpha-hydroxylase/17,20-lyase (CYP17): potential agents for the treatment of prostate cancer
Curr. Pharm. Des.
5
163-180
1999
Macacine alphaherpesvirus 1, Homo sapiens, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Auchus, R.J.; Miller, W.L.
Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations
Mol. Endocrinol.
13
1169-1182
1999
Homo sapiens (P05093), Homo sapiens
Manually annotated by BRENDA team
Brock, B.J.; Waterman, M.R.
The use of random chimeragenesis to study structure/function properties of rat and human P450c17
Arch. Biochem. Biophys.
373
401-408
2000
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Njar, V.C.; Kato, K.; Nnane, I.P.; Grigoryev, D.N.; Long, B.J.; Brodie, A.M.
Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17alpha-hydroxylase-C17,20-lyase (P450(17)alpha): potential agents for the treatment of prostate cancer
J. Med. Chem.
41
902-912
1998
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Bahshwan, S.A.; Owen, C.P.; Nicholls, P.J.; Smith, H.J.; Ahmadi, M.
Some 1-[(benzofuran-2-yl)methyl]imidazoles as inhibitors of 17alpha-hydroxylase: 17,20-lyase (P450 17) and their specificity patterns
J. Pharm. Pharmacol.
50
1109-1116
1998
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Beaudoin, C.; Lavallee, B.; Tremblay, Y.; Hu, D.W.; Breton, R.; De Launoit, Y.; Belanger, A.
Modulation of 17alpha-hydroxylase/17,20-lyase activity of guinea pig cytochrome P450c17 by site-directed mutagenesis
DNA Cell Biol.
17
707-715
1998
Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
Zhuang, Y.; Zapp, J.; Hartmann, R.W.
Synthesis of Z- and E-1-methyl-2-(1-hydroximinoethyl)-6-methoxy-3,4-dihydronaphthalene and evaluation as inhibitors of 17alpha-hydroxylase-C17,20-lyase (P450 17)
Arch. Pharm.
330
359-361
1997
Homo sapiens
Manually annotated by BRENDA team
Njar, V.C.; Klus, G.T.; Johnson, H.H.; Brodie, A.M.
Synthesis of novel 21-trifluoropregnane steroids: inhibitors of 17alpha-hydroxylase/17,20-lyase (17alpha-lyase)
Steroids
62
468-473
1997
Rattus norvegicus
Manually annotated by BRENDA team
Cloutier, M.; Fleury, A.; Courtemanche, J.; Ducharme, L.; Mason, J.I.; Lehoux, J.G.
Characterization of the adrenal cytochrome P450C17 in the hamster, a small animal model for the study of adrenal dehydroepiandrosterone biosynthesis
DNA Cell Biol.
16
357-368
1997
Mesocricetus auratus
Manually annotated by BRENDA team
Chan, F.C.; Potter, G.A.; Barrie, S.E.; Haynes, B.P.; Rowlands, M.G.; Houghton, J.; Jarman, M.
3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17alpha) (17alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer
J. Med. Chem.
39
3319-3323
1996
Homo sapiens
Manually annotated by BRENDA team
Fournet, N.; Weitsman, S.R.; Zachow, R.J.; Magoffin, D.A.
Transforming growth factor-beta inhibits ovarian 17alpha-hydroxylase activity by a direct noncompetitive mechanism
Endocrinology
137
166-174
1996
Rattus norvegicus
Manually annotated by BRENDA team
Potter, G.A.; Barrie, S.E.; Jarman, M.; Rowlands, M.G.
Novel steroidal inhibitors of human cytochrome P45017alpha (17alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer
J. Med. Chem.
38
2463-2471
1995
Homo sapiens
Manually annotated by BRENDA team
Imai, T.; Globerman, H.; Gertner, J.M.; Kagawa, N.; Waterman, M.R.
Expression and purification of functional human 17alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17alpha-hydroxylase/17,20-lyase deficiency
J. Biol. Chem.
268
19681-19689
1993
Homo sapiens
Manually annotated by BRENDA team
Bicikova, M.; Hampl, R.; Hill, M.; Starka, L.
Inhibition of steroid 17alpha-hydroxylase and C17,20-lyase in the human testis by epitestosterone
J. Steroid Biochem. Mol. Biol.
46
515-518
1993
Homo sapiens
Manually annotated by BRENDA team
Kuwada, M.; Sone, Y.; Kitajima, R.
Purification from adult pig testicular P-450 and 17alpha-hydroxylase activity of P-450 containing liposomal membranes
Biochem. Biophys. Res. Commun.
196
816-824
1993
Sus scrofa
Manually annotated by BRENDA team
Sakaki, T.; Shibata, M.; Yabusaki, Y.; Murakami, H.; Ohkawa, H.
Genetically engineered P450 monooxygenases: construction of bovine P450c17/yeast reductase fused enzymes
DNA Cell Biol.
9
27-36
1990
Bos taurus
Manually annotated by BRENDA team
Angelastro, M.R.; Laughlin, M.E.; Schatzman, G.L.; Bey, P.; Blohm, T.R.
17beta-(Cyclopropylamino)-androst-5-en-3 beta-ol, a selective mechanism-based inhibitor of cytochrome P450(17alpha) (steroid 17alpha-hydroxylase/C17-20 lyase)
Biochem. Biophys. Res. Commun.
162
1571-1577
1989
Homo sapiens
Manually annotated by BRENDA team
Schatzman, G.L.; Laughlin, M.E.; Blohm, T.R.
A normal phase high-performance liquid chromatography system for steroid 17alpha-hydroxylase/C17-20 lyase (cytochrome P-45021scc) assays
Anal. Biochem.
175
219-226
1988
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Sheets, J.J.; Zuber, M.X.; McCarthy, J.L.; Vickery, L.E.; Waterman, M.R.
Discriminatory inhibition of adrenocortical 17alpha-hydroxylase activity by inhibitors of cholesterol side chain cleavage cytochrome P-450
Arch. Biochem. Biophys.
242
297-305
1985
Bos taurus
Manually annotated by BRENDA team
Shinzawa, K.; Kominami, S.; Takemori, S.
Studies on cytochrome P-450 (P-450 17alpha,lyase) from guinea pig adrenal microsomes. Dual function of a single enzyme and effect of cytochrome b5
Biochim. Biophys. Acta
833
151-160
1985
Cavia porcellus
Manually annotated by BRENDA team
Nakajin, S.; Shinoda, M.; Haniu, M.; Shively, J.E.; Hall, P.F.
C21 steroid side chain cleavage enzyme from porcine adrenal microsomes. Purification and characterization of the 17alpha-hydroxylase/C17,20-lyase cytochrome P-450
J. Biol. Chem.
259
3971-3976
1984
Sus scrofa
Manually annotated by BRENDA team
Nakajin, S.; Shinoda, M.; Hall, P.F.
Purification and properties of 17alpha-hydroxylase from microsomes of pig adrenal: a second C21 side-chain cleavage system
Biochem. Biophys. Res. Commun.
111
512-517
1983
Sus scrofa
Manually annotated by BRENDA team
Nakajin, S.; Shively, J.E.; Yuan, P.M.; Hall, P.F.
Microsomal cytochrome P-450 from neonatal pig testis: two enzymatic activities (17alpha-hydroxylase and c17,20-lyase) associated with one protein
Biochemistry
20
4037-4042
1981
Sus scrofa
Manually annotated by BRENDA team
Nakajin, S.; Hall, P.F.
Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of A C21 steroid side-chain cleavage system (17alpha-hydroxylase-C17,20 lyase)
J. Biol. Chem.
256
3871-3876
1981
Sus scrofa
Manually annotated by BRENDA team
Fevold, H.R.; Wilson, P.L.; Slanina, S.M.
ACTH-stimulated rabbit adrenal 17alpha-hydroxylase. Kinetic properties and a comparison with those of 3beta-hydroxysteroid dehydrogenase
J. Steroid Biochem.
9
1033-1041
1978
Oryctolagus cuniculus
Manually annotated by BRENDA team
Fan, D.F.; Oshima, H.; Troen, B.R.; Troen, P.
Studies of the human testis. IV. Testicular 20alpha-hydroxysteroid dehydrogenase and steroid 17alpha-hydroxylase
Biochim. Biophys. Acta
360
88-99
1974
Homo sapiens
Manually annotated by BRENDA team
Namiki, M.; Kitamura, M.; Buczko, E.; Dufau, M.L.
Rat testis P-45017alpha cDNA: the deduced amino acid sequence, expression and secondary structural configuration
Biochem. Biophys. Res. Commun.
157
705-712
1988
Rattus norvegicus
Manually annotated by BRENDA team
Gupta, M.K.; Guryev, O.L.; Auchus, R.J.
5alpha-reduced C21 steroids are substrates for human cytochrome P450c17
Arch. Biochem. Biophys.
418
151-160
2003
Homo sapiens
Manually annotated by BRENDA team
Gilep, A.A.; Estabrook, R.W.; Usanov, S.A.
Chimerogenesis in estimation of specificity and pathway directions for cytochrome P45017alpha catalyzed reactions
Biochemistry (Moscow)
69
364-375
2004
Cavia porcellus (Q64410)
Manually annotated by BRENDA team
Liu, Y.; Yao, Z.X.; Papadopoulos, V.
Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells
Mol. Endocrinol.
19
1918-1931
2005
Mus musculus
Manually annotated by BRENDA team
Naffin-Olivos, J.L.; Auchus, R.J.
Human cytochrome b5 requires residues E48 and E49 to stimulate the 17,20-lyase activity of cytochrome P450c17
Biochemistry
45
755-762
2006
Homo sapiens
Manually annotated by BRENDA team
Owen, C.P.; Dhanani, S.; Patel, C.H.; Shahid, I.; Ahmed, S.
Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha))
Bioorg. Med. Chem. Lett.
16
4011-4015
2006
Rattus norvegicus
Manually annotated by BRENDA team
Patel, C.H.; Dhanani, S.; Owen, C.P.; Ahmed, S.
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha))
Bioorg. Med. Chem. Lett.
16
4752-4756
2006
Rattus norvegicus
Manually annotated by BRENDA team
Flueck, C.E.; Yaworsky, D.C.; Miller, W.L.
Effects of anticonvulsants on human p450c17 (17alpha-hydroxylase/17,20 lyase) and 3beta-hydroxysteroid dehydrogenase type 2
Epilepsia
46
444-448
2005
Homo sapiens
Manually annotated by BRENDA team
Taniguchi, F.; Couse, J.F.; Rodriguez, K.F.; Emmen, J.M.; Poirier, D.; Korach, K.S.
Estrogen receptor-alpha mediates an intraovarian negative feedback loop on thecal cell steroidogenesis via modulation of Cyp17a1 (cytochrome P450, steroid 17alpha-hydroxylase/17,20 lyase) expression
FASEB J.
21
586-595
2007
Mus musculus
Manually annotated by BRENDA team
Souter, I.; Munir, I.; Mallick, P.; Weitsman, S.R.; Geller, D.H.; Magoffin, D.A.
Mutagenesis of putative serine-threonine phosphorylation sites proximal to Arg255 of human cytochrome P450c17 does not selectively promote its 17,20-lyase activity
Fertil. Steril.
85 Suppl 1
1290-1299
2006
Homo sapiens
Manually annotated by BRENDA team
Brooke, A.M.; Taylor, N.F.; Shepherd, J.H.; Gore, M.E.; Ahmad, T.; Lin, L.; Rumsby, G.; Papari-Zareei, M.; Auchus, R.J.; Achermann, J.C.; Monson, J.P.
A novel point mutation in P450c17 (CYP17) causing combined 17alpha-hydroxylase/17,20-lyase deficiency
J. Clin. Endocrinol. Metab.
91
2428-2431
2006
Homo sapiens
Manually annotated by BRENDA team
Do Rego, J.L.; Tremblay, Y.; Luu-The, V.; Repetto, E.; Castel, H.; Vallarino, M.; Belanger, A.; Pelletier, G.; Vaudry, H.
Immunohistochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17alpha-hydroxylase/C17, 20-lyase (P450C17) in the frog brain and pituitary
J. Neurochem.
100
251-268
2007
Pelophylax lessonae
Manually annotated by BRENDA team
Lee, L.S.; Shu, W.J.; Wu, C.M.; Hsieh, C.H.; Chen, S.M.; Hu, C.J.; Chen, W.Y.; Chung, B.C.
A novel compound heterozygous mutation of K494_V495 deletion plus R496L and D487_F489 deletion in extreme C-terminus of cytochrome P450c17 causes 17alpha-hydroxylase deficiency
Mol. Cell. Endocrinol.
249
16-20
2006
Homo sapiens
Manually annotated by BRENDA team
Kolar, N.W.; Swart, A.C.; Mason, J.I.; Swart, P.
Functional expression and characterisation of human cytochrome P45017alpha in Pichia pastoris
J. Biotechnol.
129
635-644
2007
Homo sapiens
Manually annotated by BRENDA team
Pechurskaya, T.A.; Lukashevich, O.P.; Gilep, A.A.; Usanov, S.A.
Engineering, expression, and purification of "soluble" human cytochrome P45017alpha and its functional characterization
Biochemistry (Moscow)
73
806-811
2008
Homo sapiens
Manually annotated by BRENDA team
Shet, M.S.; Fisher, C.W.; Tremblay, Y.; Belanger, A.; Conley, A.J.; Mason, J.I.; Estabrook, R.W.
Comparison of the 17 alpha-hydroxylase/C17,20-lyase activities of porcine, guinea pig and bovine P450c17 using purified recombinant fusion proteins containing P450c17 linked to NADPH-P450 reductase
Drug Metab. Rev.
39
289-307
2007
Bos taurus, Cavia porcellus, Sus scrofa
Manually annotated by BRENDA team
Tiosano, D.; Knopf, C.; Koren, I.; Levanon, N.; Hartmann, M.F.; Hochberg, Z.; Wudy, S.A.
Metabolic evidence for impaired 17alpha-hydroxylase activity in a kindred bearing the E305G mutation for isolate 17,20-lyase activity
Eur. J. Endocrinol.
158
385-392
2008
Homo sapiens
Manually annotated by BRENDA team
Beshay, V.E.; Havelock, J.C.; Sirianni, R.; Ye, P.; Suzuki, T.; Rainey, W.E.; Carr, B.R.
The mechanism for protein kinase C inhibition of androgen production and 17alpha-hydroxylase expression in a theca cell tumor model
J. Clin. Endocrinol. Metab.
92
4802-4809
2007
Homo sapiens
Manually annotated by BRENDA team
Owen, C.P.; Shahid, I.; Olusanjo, M.S.; Patel, C.H.; Dhanani, S.; Ahmed, S.
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha))
J. Steroid Biochem. Mol. Biol.
111
117-127
2008
Rattus norvegicus
Manually annotated by BRENDA team
Pattison, J.C.; Saltzman, W.; Abbott, D.H.; Hogan, B.K.; Nguyen, A.D.; Husen, B.; Einspanier, A.; Conley, A.J.; Bird, I.M.
Gender and gonadal status differences in zona reticularis expression in marmoset monkey adrenals: Cytochrome b5 localization with respect to cytochrome P450 17,20-lyase activity
Mol. Cell. Endocrinol.
265-266
93-101
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Hu, Q.; Negri, M.; Jahn-Hoffmann, K.; Zhuang, Y.; Olgen, S.; Bartels, M.; Mueller-Vieira, U.; Lauterbach, T.; Hartmann, R.W.
Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge
Bioorg. Med. Chem.
16
7715-7727
2008
Homo sapiens
Manually annotated by BRENDA team
Du, J.; Liang, X.; Zeng, H.; Shu, Y.; Yao, S.; Zhu, B.; Zhuang, G.
Effect of small interfering RNAs of cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) on androgen biosynthesis in theca cells
Cell Biol. Int.
32
469-472
2008
Homo sapiens
Manually annotated by BRENDA team
Tian, Q.; Zhang, Y.; Lu, Z.
Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases
Gynecol. Endocrinol.
24
362-367
2008
Homo sapiens
Manually annotated by BRENDA team
Bruno, R.D.; Gover, T.D.; Burger, A.M.; Brodie, A.M.; Njar, V.C.
17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response
Mol. Cancer Ther.
7
2828-2836
2008
Homo sapiens
Manually annotated by BRENDA team
Shackleton, C.H.; Neres, M.S.; Hughes, B.A.; Stewart, P.M.; Kater, C.E.
17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites
Steroids
73
652-656
2008
Homo sapiens
Manually annotated by BRENDA team
Pinto-Bazurco Mendieta, M.; Negri, M.; Hu, Q.; Hille, U.; Jagusch, C.; Jahn-Hoffmann, K.; Mueller-Vieira, U.; Schmidt, D.; Lauterbach, T.; Hartmann, R.
CYP17 inhibitors. Annulations of additional rings in methylene imidazole substituted biphenyls: Synthesis, biological evaluation and molecular modelling
Arch. Pharm.
341
547-609
2008
Homo sapiens
Manually annotated by BRENDA team
Ahmed, S.; Shahid, I.; Dhanani, S.; Owen, C.P.
Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha))
Bioorg. Med. Chem. Lett.
19
4698-4701
2009
Homo sapiens
Manually annotated by BRENDA team
Turan, S.; Bereket, A.; Guran, T.; Akcay, T.; Papari-Zareei, M.; Auchus, R.J.
Puberty in a case with novel 17-hydroxylase mutation and the putative role of estrogen in development of pubic hair
Eur. J. Endocrinol.
160
325-330
2009
Homo sapiens
Manually annotated by BRENDA team
Hille, U.E.; Hu, Q.; Vock, C.; Negri, M.; Bartels, M.; Mueller-Vieira, U.; Lauterbach, T.; Hartmann, R.W.
Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls
Eur. J. Med. Chem.
44
2765-2775
2009
Homo sapiens
Manually annotated by BRENDA team
Chen, C.F.; Wen, H.S.; Wang, Z.P.; He, F.; Zhang, J.R.; Chen, X.Y.; Jin, G.X.; Shi, B.; Shi, D.; Yang, Y.P.; Li, J.F.; Qi, B.X.; Li, N.
Cloning and expression of P450c17-I (17alpha-hydroxylase/17,20-lyase) in brain and ovary during gonad development in Cynoglossus semilaevis
Fish Physiol. Biochem.
36
1001-1012
2010
Cynoglossus semilaevis (B2D2I4)
Manually annotated by BRENDA team
Dhir, V.; Reisch, N.; Bleicken, C.M.; Lebl, J.; Kamrath, C.; Schwarz, H.P.; Groetzinger, J.; Sippell, W.G.; Riepe, F.G.; Arlt, W.; Krone, N.
Steroid 17alpha-hydroxylase deficiency: functional characterization of four mutations (A174E, V178D, R440C, L465P) in the CYP17A1 gene
J. Clin. Endocrinol. Metab.
94
3058-3064
2009
Homo sapiens
Manually annotated by BRENDA team
Pinto-Bazurco Mendieta, M.A.; Negri, M.; Jagusch, C.; Mueller-Vieira, U.; Lauterbach, T.; Hartmann, R.W.
Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer
J. Med. Chem.
51
5009-5018
2008
Homo sapiens
Manually annotated by BRENDA team
Ogishima, T.; Mitani, F.; Suematsu, M.
Cytochrome P-450(17alpha) in beta-cells of rat pancreas and its local steroidogenesis
J. Steroid Biochem. Mol. Biol.
111
80-86
2008
Rattus norvegicus
Manually annotated by BRENDA team
Sakurai, N.; Maruo, K.; Haraguchi, S.; Uno, Y.; Oshima, Y.; Tsutsui, K.; Matsuda, Y.; Do Rego, J.L.; Pelletier, G.; Vaudry, H.; Nakamura, M.
Immunohistochemical detection and biological activities of CYP17 (P450c17) in the indifferent gonad of the frog Rana rugosa
J. Steroid Biochem. Mol. Biol.
112
5-12
2008
Glandirana rugosa (A6P663)
Manually annotated by BRENDA team
Sreenivasulu, G.; Senthilkumaran, B.
A role for cytochrome P450 17alpha-hydroxylase/c17-20 lyase during shift in steroidogenesis occurring in ovarian follicles prior to oocyte maturation
J. Steroid Biochem. Mol. Biol.
115
77-85
2009
Clarias gariepinus (C7B608), Clarias gariepinus
Manually annotated by BRENDA team
Katsumata, N.; Ogawa, E.; Fujiwara, I.; Fujikura, K.
Novel CYP17A1 mutation in a Japanese patient with combined 17alpha-hydroxylase/17,20-lyase deficiency
Metab. Clin. Exp.
59
275-278
2009
Homo sapiens
Manually annotated by BRENDA team
Li, Y.; Liang, X.; Wei, L.; Xiong, Y.; Yang, X.; Shi, H.; Yang, Z.
Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo
Reprod. Biol. Endocrinol.
7
73-80
2009
Rattus norvegicus
Manually annotated by BRENDA team
Ivanyi, Z.; Woelfling, J.; Goerbe, T.; Szecsi, M.; Wittmann, T.; Schneider, G.
Synthesis of regioisomeric 17beta-N-phenylpyrazolyl steroid derivatives and their inhibitory effect on 17alpha-hydroxylase/C(17,20)-lyase
Steroids
75
450-456
2010
Rattus norvegicus
Manually annotated by BRENDA team
Owen, C.P.; Shahid, I.; Lee, W.Y.; Ahmed, S.
Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes
Bioorg. Med. Chem. Lett.
20
5345-5348
2010
Rattus norvegicus
Manually annotated by BRENDA team
Kaku, T.; Matsunaga, N.; Ojida, A.; Tanaka, T.; Hara, T.; Yamaoka, M.; Kusaka, M.; Tasaka, A.
17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors
Bioorg. Med. Chem.
19
1751-1770
2011
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Kaku, T.; Tsujimoto, S.; Matsunaga, N.; Tanaka, T.; Hara, T.; Yamaoka, M.; Kusaka, M.; Tasaka, A.
17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors
Bioorg. Med. Chem.
19
2428-2442
2011
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Stefanachi, A.; Favia, A.; Nicolotti, O.; Leonetti, F.; Pisani, L.; Catto, M.; Zimmer, C.; Hartmann, R.; Carotti, A.
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-alpha-hydroxylase/C17-20 lyase
J. Med. Chem.
54
1613-1625
2011
Homo sapiens
Manually annotated by BRENDA team
Manca, P.; Mulliri, G.; Burrai, G.P.; Pirino, S.; Mameli, O.
Immunohistochemical localisation and molecular expression of the steroidogenic enzyme cytochrome p450 17alpha-hydroxylase/c(17,20)-lyase in the vestibular nuclei of adult male rats
J. Neuroendocrinol.
23
444-449
2011
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Swart, A.C.; Storbeck, K.H.; Swart, P.
A single amino acid residue, Ala 105, confers 16alpha-hydroxylase activity to human cytochrome P450 17alpha-hydroxylase/17,20 lyase
J. Steroid Biochem. Mol. Biol.
119
112-120
2010
Capra hircus (A5HEW0), Capra hircus, Homo sapiens (P05093), Homo sapiens, Sus scrofa (P19100), Sus scrofa, Papio ursinus (Q9GLD2), Capra hircus South African angora (A5HEW0)
Manually annotated by BRENDA team
Akhtar, M.; Wright, J.N.; Lee-Robichaud, P.
A review of mechanistic studies on aromatase (CYP19) and 17alpha-hydroxylase-17,20-lyase (CYP17)
J. Steroid Biochem. Mol. Biol.
125
2-12
2010
Homo sapiens
Manually annotated by BRENDA team
Chen, Y.; Saini, S.; Zaman, M.S.; Hirata, H.; Shahryari, V.; Deng, G.; Dahiya, R.
Cytochrome P450 17 (CYP17) is involved in endometrial cancinogenesis through apoptosis and invasion pathways
Mol. Carcinog.
50
16-23
2011
Homo sapiens
Manually annotated by BRENDA team
Khatri, Y.; Gregory, M.C.; Grinkova, Y.V.; Denisov, I.G.; Sligar, S.G.
Active site proton delivery and the lyase activity of human CYP17A1
Biochem. Biophys. Res. Commun.
443
179-184
2014
Homo sapiens (P05093)
Manually annotated by BRENDA team
Sushko, T.A.; Gilep, A.A.; Usanov, S.A.
Mechanism of intermolecular interactions of microsomal cytochrome P450s CYP17 and CYP21 involved in steroid hormone biosynthesis
Biochemistry (Moscow)
77
585-592
2012
Homo sapiens (P05093)
Manually annotated by BRENDA team
Yoshimoto, F.K.; Zhou, Y.; Peng, H.M.; Stidd, D.; Yoshimoto, J.A.; Sharma, K.K.; Matthew, S.; Auchus, R.J.
Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates
Biochemistry
51
7064-7077
2012
Homo sapiens (P05093)
Manually annotated by BRENDA team
Schonemann, M.D.; Muench, M.O.; Tee, M.K.; Miller, W.L.; Mellon, S.H.
Expression of P450c17 in the human fetal nervous system
Endocrinology
153
2494-2505
2012
Homo sapiens
Manually annotated by BRENDA team
Jin, G.X.; Wen, H.S.; He, F.; Li, J.F.; Chen, C.F.; Zhang, J.R.; Chen, X.Y.; Shi, B.; Shi, D.; Yang, Y.P.; Qi, B.X.; Li, N.
Molecular cloning, characterization expression of P450c17-I and P450c17-II and their functions analysis during the reproductive cycle in males of barfin flounder (Verasper moseri)
Fish Physiol. Biochem.
38
807-817
2012
Verasper moseri (B3VLB1), Verasper moseri (B6UPD2)
Manually annotated by BRENDA team
Mu, W.J.; Wen, H.S.; He, F.; Li, J.F.; Liu, M.; Ma, R.Q.; Zhang, Y.Q.; Hu, J.; Qi, B.X.
Cloning and expression analysis of the cytochrome P450c17s enzymes during the reproductive cycle in ovoviviparous Korean rockfish (Sebastes schlegeli)
Gene
512
444-449
2013
Sebastes schlegelii
Manually annotated by BRENDA team
Hough, D.; Cloete, S.W.; Storbeck, K.; Swart, A.C.; Swart, P.
Cortisol production in sheep is influenced by the functional expression of two cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) isoforms
J. Anim. Sci.
91
1193-1206
2013
Ovis aries (Q29497)
Manually annotated by BRENDA team
Estrada, D.F.; Laurence, J.S.; Scott, E.E.
Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR
J. Biol. Chem.
288
17008-17018
2013
Homo sapiens (P05093)
Manually annotated by BRENDA team
Tee, M.K.; Miller, W.L.
Phosphorylation of human cytochrome P450c17 by p38alpha selectively increases 17,20 lyase activity and androgen biosynthesis
J. Biol. Chem.
288
23903-23913
2013
Homo sapiens (P05093)
Manually annotated by BRENDA team
Yoshimoto, F.K.; Desilets, M.C.; Auchus, R.J.
Synthesis of halogenated pregnanes, mechanistic probes of steroid hydroxylases CYP17A1 and CYP21A2
J. Steroid Biochem. Mol. Biol.
128
38-50
2012
Homo sapiens (P05093)
Manually annotated by BRENDA team
Szabo, N.; Ajdukovic, J.J.; Djurendic, E.A.; Sakac, M.N.; Ignath, I.; Gardi, J.; Mahmoud, G.; Klisuric, O.R.; Jovanovic-Santa, S.; Penov Gasi, K.M.; Szecsi, M.
Determination of 17alpha-hydroxylase-C17,20-lyase (P45017alpha) enzyme activities and their inhibition by selected steroidal picolyl and picolinylidene compounds
Acta Biol. Hung.
66
41-51
2015
Rattus norvegicus
Manually annotated by BRENDA team
Cui, Y.L.; Xue, Q.; Zheng, Q.C.; Zhang, J.L.; Kong, C.P.; Fan, J.R.; Zhang, H.X.
Structural features and dynamic investigations of the membrane-bound cytochrome P450 17A1
Biochim. Biophys. Acta
1848
2013-2021
2015
Homo sapiens (P05093)
Manually annotated by BRENDA team
Estrada, D.F.; Skinner, A.L.; Laurence, J.S.; Scott, E.E.
Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5
J. Biol. Chem.
289
14310-14320
2014
Homo sapiens (P05093), Homo sapiens
Manually annotated by BRENDA team
Petrunak, E.M.; DeVore, N.M.; Porubsky, P.R.; Scott, E.E.
Structures of human steroidogenic cytochrome P450 17A1 with substrates
J. Biol. Chem.
289
32952-32964
2014
Homo sapiens (P05093), Homo sapiens
Manually annotated by BRENDA team
Peng, H.M.; Liu, J.; Forsberg, S.E.; Tran, H.T.; Anderson, S.M.; Auchus, R.J.
Catalytically relevant electrostatic interactions of cytochrome P450c17 (CYP17A1) and cytochrome b5
J. Biol. Chem.
289
33838-33849
2014
Homo sapiens (P05093)
Manually annotated by BRENDA team
Pallan, P.S.; Nagy, L.D.; Lei, L.; Gonzalez, E.; Kramlinger, V.M.; Azumaya, C.M.; Wawrzak, Z.; Waterman, M.R.; Guengerich, F.P.; Egli, M.
Structural and kinetic basis of steroid 17?,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2
J. Biol. Chem.
290
3248-3268
2015
Danio rerio (A7U483), Danio rerio (B3DH80), Danio rerio
Manually annotated by BRENDA team
Oskarsson, A.; Spatafora, C.; Tringali, C.; Andersson, A.O.
Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs
Prostate
74
839-851
2014
Homo sapiens (P05093)
Manually annotated by BRENDA team
Al-Masoudi, N.A.; Mahdi, K.M.; Abdul-Rida, N.A.; Saeed, B.A.; Engel, M.
A new pregnenolone analogues as privileged scaffolds in inhibition of CYP17 hydroxylase enzyme. Synthesis and in silico molecular docking study
Steroids
100
52-59
2015
Homo sapiens
Manually annotated by BRENDA team
Ackermann, D.; Pruijm, M.; Ponte, B.; Guessous, I.; Ehret, G.; Escher, G.; Dick, B.; Al-Alwan, H.; Vuistiner, P.; Paccaud, F.; Burnier, M.; Pechere-Bertschi, A.; Martin, P.Y.; Vogt, B.; Mohaupt, M.; Bochud, M.
CYP17A1 enzyme activity is linked to ambulatory blood pressure in a family-based population study
Am. J. Hypertens.
29
484-493
2016
Homo sapiens (P05093)
Manually annotated by BRENDA team
Yoshimoto, F.K.; Peng, H.M.; Zhang, H.; Anderson, S.M.; Auchus, R.J.
Epoxidation activities of human cytochromes P450c17 and P450c21
Biochemistry
53
7531-7540
2014
Homo sapiens (P05093), Homo sapiens
Manually annotated by BRENDA team
Gonzalez, E.; Guengerich, F.P.
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1
J. Biol. Chem.
292
13168-13185
2017
Homo sapiens (P05093)
Manually annotated by BRENDA team
Capper, C.P.; Liu, J.; McIntosh, L.R.; Larios, J.M.; Johnson, M.D.; Hollenberg, P.F.; Osawa, Y.; Auchus, R.J.; Rae, J.M.
Functional characterization of the G162R and D216H genetic variants of human CYP17A1
J. Steroid Biochem. Mol. Biol.
178
159-166
2017
Homo sapiens (P05093)
Manually annotated by BRENDA team
Simonov, A.N.; Holien, J.K.; Yeung, J.C.; Nguyen, A.D.; Corbin, C.J.; Zheng, J.; Kuznetsov, V.L.; Auchus, R.J.; Conley, A.J.; Bond, A.M.; Parker, M.W.; Rodgers, R.J.; Martin, L.L.
Mechanistic scrutiny identifies a kinetic role for cytochrome b5 regulation of human cytochrome P450c17 (CYP17A1, P450 17A1)
PLoS ONE
10
e0141252
2015
Homo sapiens (P05093)
Manually annotated by BRENDA team
Kostin, V.A.; Zolottsev, V.A.; Kuzikov, A.V.; Masamrekh, R.A.; Shumyantseva, V.V.; Veselovsky, A.V.; Stulov, S.V.; Novikov, R.A.; Timofeev, V.P.; Misharin, A.Y.
Oxazolinyl derivatives of [17(20)E]-21-norpregnene differing in the structure of A and B rings. Facile synthesis and inhibition of CYP17A1 catalytic activity
Steroids
115
114-122
2016
Homo sapiens (P05093)
Manually annotated by BRENDA team