Reference on EC 1.14.14.23 - cholesterol 7alpha-monooxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mitton, J.R.; Scholan, N.A.; Boyd, G.S.
The oxidation of cholesterol in rat liver sub-cellular particles. The cholesterol-7-alpha-hydroxylase enzyme system
Eur. J. Biochem.
20
569-579
1971
Rattus norvegicus
Boyd, G.S.; Grimwade, A.M.; Lawson, M.E.
Studies on rat-liver microsomal cholesterol 7alpha-hydroxylase
Eur. J. Biochem.
37
334-340
1973
Rattus norvegicus
Rush, W.R.; Gibson, G.G.; Parke, D.V.
The purification and reconstitution of cytochrome P-450-dependent cholesterol 7alpha-hydroxylase activity from rat liver microsomal fractions
Biochem. Soc. Trans.
8
102-103
1980
Rattus norvegicus
Van Cantfort, J.; Gielen, J.
Cholesterol 7alpha-hydroxylase. 2. Biochemical properties and participation of endogenous cholesterol in the assay in vitro
Eur. J. Biochem.
55
33-40
1975
Rattus norvegicus
Andersson, S.; Bostrm, H.; Danielsson, H.; Wikvall, K.
Purification from rabbit and rat liver of cytochromes P-450 involved in bile acid biosynthesis
Methods Enzymol.
111
364-377
1985
Rattus norvegicus
Erickson, S.K.; Bsterling, B.
Cholesterol 7alpha-hydroxylase from human liver: partial purification and reconstruction into defined phospholipid-cholesterol vesicles
J. Lipid Res.
22
872-876
1981
Homo sapiens
Nguyen, L.B.; Shefer, S.; Salen, G.; Ness, G.; Tanaka, R.D.; Packin, V.; Thomas, P.; Shore, V.; Batta, A.
Purification of cholesterol 7alpha-hydroxylase from human and rat liver and production of inhibiting polyclonal antibodies
J. Biol. Chem.
265
4541-4546
1990
Homo sapiens, Rattus norvegicus
Kalles, I.; Wikvall, K.
Role of sulfhydryl groups in catalytic activity of purified cholesterol 7alpha-hydroxylase system from rabbit and rat liver microsomes
Biochem. Biophys. Res. Commun.
100
1361-1369
1981
Oryctolagus cuniculus, Rattus norvegicus
Waxman, D.J.
Rat hepatic cholesterol 7alpha-hydroxylase: biochemical properties and comparison to constitutive and xenobiotic-inducible cytochrome P-450 enzymes
Arch. Biochem. Biophys.
247
335-345
1986
Rattus norvegicus
Chiang, J.Y.L.; Miller, W.F.; Lin, G.M.
Regulation of cholesterol 7alpha-hydroxylase in the liver. Purification of cholesterol 7alpha-hydroxylase and the immunochemical evidence for the induction of cholesterol 7alpha-hydroxylase by cholestyramine and circadian rhythm
J. Biol. Chem.
265
3889-3897
1990
Rattus norvegicus
Suckling, K.E.; Jackson, B.; Suffolk, R.A.; Houghton, J.D.; Suckling, C.J.
Effects of 6,6-difluorocholestanol and 7,7-difluorocholestanol on hepatic enzymes of cholesterol metabolism
Biochim. Biophys. Acta
1002
401-404
1989
Rattus norvegicus
Ogishima, T.; Deguchi, S.; Okuda, K.
Purification and characterization of cholesterol 7alpha-hydroxylase from rat liver microsomes
J. Biol. Chem.
262
7646-7650
1987
Rattus norvegicus
Danielsson, H.; Kalles, I.; Wikvall, K.
Regulation of hydroxylations in biosynthesis of bile acids. Isolation of a protein from rat liver cytosol stimulating reconstituted cholesterol 7alpha-hydroxylase activity
J. Biol. Chem.
259
4258-4262
1984
Rattus norvegicus
Ozasa, S.; Boyd, G.S.
Cholesterol 7alpha-hydroxylase of rat liver. Studies on the solubilisation, resolution and reconstitution of the enzyme complex
Eur. J. Biochem.
119
263-272
1981
Rattus norvegicus
Hansson, R.; Wikvall, K.
Properties of reconstituted cholesterol 7alpha-hydroxylase system from rat and rabbit liver microsomes
Eur. J. Biochem.
93
419-426
1979
Oryctolagus cuniculus, Rattus norvegicus
Miki, N.; Miura, R.; Miyake, Y.
Purification and characterization of cholesterol 7alpha-hydroxylase cytochrome P-450 of untreated rabbit liver microsomes
J. Biochem.
101
1087-1094
1987
Oryctolagus cuniculus
Nguyen, L.B.; Shefer, S.; Salen, G.; Chiang, J.Y.L.; Patel, M.
Cholesterol 7alpha-hydroxylase activities from human and rat liver are modulated in vitro posttranslationally by phosphorylation/dephosphorylation
Hepatology
24
1468-1474
1996
Homo sapiens, Rattus norvegicus
Souidi, M.; Parquet, M.; Ferezou, J.; Lutton, C.
Modulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase activities by steroids and physiological conditions in hamster
Life Sci.
17
1585-1593
1999
Mesocricetus auratus
Yamada, M.; Nagatomo, J.; Setoguchi, Y.; Kuroki, N.; Higashi, s.; Setoguchi, T.
Circadian Rhytms of sterol 12alpha-hydroxylase, cholesterol 7alpha-hydroxylase and DBP involved in rat cholesterol catabolism
Biol. Chem.
381
1149-1153
2000
Rattus norvegicus
Galman, C.; Arvidsson, I.; Angelin, B.; Rudling, M.
Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood
J. Lipid Res.
44
859-866
2003
Homo sapiens, Mus musculus, Rattus norvegicus
Kinowaki, M.; Tanaka, S.; Maeda, Y.; Higashi, S.; Okuda, K.; Setoguchi, T.
Half-life of cholesterol 7alpha-hydroxylase activity and enzyme mass differ in animals and humans when determined by a monoclonal antibody against human cholesterol 7alpha-hydroxylase
J. Steroid Biochem. Mol. Biol.
81
377-380
2002
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Tanaka, S.; Kinowaki, M.; Eto, T.A.; Ota, Y.; Maeda, Y.; Okuda, K.; Setoguchi, T.; Chijiiwa, K.
Sulfhydryl groups responsible for extreme lability of human cholesterol 7alpha-hydroxylase identified by site-directed mutagenesis
J. Steroid Biochem. Mol. Biol.
86
35-40
2003
Cricetulus griseus, Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Tiemann, M.; Han, Z.; Soccio, R.; Bollineni, J.; Shefer, S.; Sehayek, E.; Breslow, J.L.
Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activity
Proc. Natl. Acad. Sci. USA
101
1846-1851
2004
Homo sapiens, Mus musculus
Shin, Y.; Vaziri, N.D.; Willekes, N.; Kim, C.H.; Joles, J.A.
Effects of gender on hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and LDL receptor in hereditary analbuminemia
Am. J. Physiol. Endocrinol. Metab.
289
E993-E998
2005
Rattus norvegicus
Maeda, Y.; Nagatomo, H.; Kuroki, N.; Nagatomo, J.; Uchiyama, F.; Shimozono, K.; Kohno, Y.; Chijiiwa, K.
Bile acid biosynthesis during liver regeneration: enzyme activities of cholesterol 7alpha-hydroxylase and 3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats
Ann. Clin. Lab. Sci.
35
323-328
2005
Rattus norvegicus
Handschin, C.; Gnerre, C.; Fraser, D.J.; Martinez-Jimenez, C.; Jover, R.; Meyer, U.A.
Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids
Arch. Biochem. Biophys.
434
75-85
2005
Gallus gallus (Q5ILH2), Gallus gallus
Abrahamsson, A.; Krapivner, S.; Gustafsson, U.; Muhrbeck, O.; Eggertsen, G.; Johansson, I.; Persson, I.; Angelin, B.; Ingelman-Sundberg, M.; Bjoerkhem, I.; Einarsson, C.; vant Hooft, F.M.
Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration
Atherosclerosis
182
37-45
2005
Homo sapiens
Stroup, D.; Ramsaran, J.R.
Cholesterol 7alpha-hydroxylase is phosphorylated at multiple amino acids
Biochem. Biophys. Res. Commun.
329
957-965
2005
Homo sapiens (P22680), Homo sapiens
Charoenteeraboon, J.; Nithipatikom, K.; Campbell, W.B.; Piyachaturawat, P.; Wilairat, P.; Rongnoparut, P.
Induction of human cholesterol 7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone
Eur. J. Pharmacol.
515
43-46
2005
Homo sapiens
Wang, J.; Olin, M.; Rozell, B.; Bjoerkhem, I.; Einarsson, C.; Eggertsen, G.; Gafvels, M.
Differential hepatocellular zonation pattern of cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) in the mouse
Histochem. Cell Biol.
127
253-261
2007
Mus musculus
Li, T.; Kong, X.; Owsley, E.; Ellis, E.; Strom, S.; Chiang, J.Y.
Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c
J. Biol. Chem.
281
28745-28754
2006
Homo sapiens (P22680), Homo sapiens
Hubacek, J.A.; Bobkova, D.
Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering
Mol. Diagn. Ther.
10
93-100
2006
Homo sapiens (P22680)
Shibata, S.; Hayakawa, K.; Egashira, Y.; Sanada, H.
Hypocholesterolemic mechanism of Chlorella: Chlorella and its indigestible fraction enhance hepatic cholesterol catabolism through up-regulation of cholesterol 7alpha-hydroxylase in rats
Biosci. Biotechnol. Biochem.
71
916-925
2007
Rattus norvegicus
Lee, M.S.; Park, J.Y.; Freake, H.; Kwun, I.S.; Kim, Y.
Green tea catechin enhances cholesterol 7alpha-hydroxylase gene expression in HepG2 cells
Br. J. Nutr.
99
1182-1185
2008
Homo sapiens
Hubacek, J.A.; Bobkova, D.; Bohuslavova, R.; Poledne, R.
Differences in expression of cholesterol 7alpha-hydroxylase between PHHC and Wistar rats
Folia Biol. (Praha)
54
18-23
2008
Rattus norvegicus
Mitro, N.; Godio, C.; De Fabiani, E.; Scotti, E.; Galmozzi, A.; Gilardi, F.; Caruso, D.; Chacon, A.B.; Crestani, M.
Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis
Hepatology
46
885-897
2007
Homo sapiens (P22680)
Cheng, Z.; Zhou, H.; Luther, M.; Yin, J.J.; Yu, L.L.
Effects of wheat antioxidants on oxygen diffusion-concentration products in liposomes and mRNA levels of HMG-CoA reductase and cholesterol 7alpha-hydroxylase in primary rat hepatocytes
J. Agric. Food Chem.
56
5033-5042
2008
Rattus norvegicus
Noshiro, M.; Usui, E.; Kawamoto, T.; Kubo, H.; Fujimoto, K.; Furukawa, M.; Honma, S.; Makishima, M.; Honma, K.; Kato, Y.
Multiple mechanisms regulate circadian expression of the gene for cholesterol 7alpha-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis
J. Biol. Rhythms
22
299-311
2007
Mus musculus (Q64505)
Li, T.; Ma, H.; Chiang, J.Y.
TGF{beta}1, TNF{alpha}, and insulin signaling crosstalk in regulation of the rat cholesterol 7{alpha}-hydroxylase gene expression
J. Lipid Res.
49
1981-1989
2008
Rattus norvegicus
Srivastava, A.; Pandey, S.N.; Choudhuri, G.; Mittal, B.
Role of genetic variant A-204C of cholesterol 7alpha-hydroxylase (CYP7A1) in susceptibility to gallbladder cancer
Mol. Genet. Metab.
94
83-89
2008
Homo sapiens
Gilardi, F.; Mitro, N.; Godio, C.; Scotti, E.; Caruso, D.; Crestani, M.; De Fabiani, E.
The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol
Pharmacol. Ther.
116
449-472
2007
Homo sapiens, Mus musculus
Wooton-Kee, C.; Cohen, D.; Vore, M.
Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat
Am. J. Physiol. Gastrointest. Liver Physiol.
294
G1009-G1016
2008
Rattus norvegicus
Burke, K.T.; Horn, P.S.; Tso, P.; Heubi, J.E.; Woollett, L.A.
Hepatic bile acid metabolism in the neonatal hamster: expansion of the bile acid pool parallels increased Cyp7a1 expression levels
Am. J. Physiol. Gastrointest. Liver Physiol.
297
G144-G151
2009
Mesocricetus auratus
Kojima, M.; Ashino, T.; Yoshida, T.; Iwakura, Y.; Sekimoto, M.; Degawa, M.
IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice
Biochem. Biophys. Res. Commun.
379
239-242
2009
Mus musculus
Li, T.; Ma, H.; Park, Y.J.; Lee, Y.K.; Strom, S.; Moore, D.D.; Chiang, J.Y.
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice
Biochim. Biophys. Acta
1791
991-996
2009
Homo sapiens, Mus musculus
Han, S.; Chiang, J.Y.
Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes
Drug Metab. Dispos.
37
469-478
2009
Homo sapiens
Song, K.H.; Li, T.; Owsley, E.; Strom, S.; Chiang, J.Y.
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression
Hepatology
49
297-305
2009
Homo sapiens
Nass, N.; Schoeps, R.; Ulbrich-Hofmann, R.; Simm, A.; Hohndorf, L.; Schmelzer, C.; Raith, K.; Neubert, R.H.; Eder, K.
Screening for nutritive peptides that modify cholesterol 7alpha-hydroxylase expression
J. Agric. Food Chem.
56
4987-4994
2008
Homo sapiens
Xie, Y.; Blanc, V.; Kerr, T.A.; Kennedy, S.; Luo, J.; Newberry, E.P.; Davidson, N.O.
Decreased expression of cholesterol 7alpha-hydroxylase and altered bile acid metabolism in Apobec-1-/- mice lead to increased gallstone susceptibility
J. Biol. Chem.
284
16860-16871
2009
Mus musculus (Q64505), Mus musculus
Taniguchi, M.; Nagao, K.; Inoue, K.; Imaizumi, K.
Cholesterol lowering effect of sulfur-containing amino acids added to a soybean protein diet in rats
J. Nutr. Sci. Vitaminol.
54
448-453
2008
Rattus norvegicus
Pond, W.G.; Mersmann, H.J.; Su, D.; McGlone, J.J.; Wheeler, M.B.; Smith, E.O.
Neonatal dietary cholesterol and alleles of cholesterol 7-alpha hydroxylase affect piglet cerebrum weight, cholesterol concentration, and behavior
J. Nutr.
138
282-286
2008
Sus scrofa
Zhang, L.; Huang, X.; Meng, Z.; Dong, B.; Shiah, S.; Moore, D.D.; Huang, W.
Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration
Mol. Endocrinol.
23
137-145
2009
Mus musculus
Zhou, X.; Han, Y.; Liu, J.; Gao, L.; Zhao, J.
Decreased protein and gene expression of hepatic cholesterol 7a-hydroxylase associated with dilated endoplasmic reticulum in chronic hypothyroid rats
Pathol. Int.
59
729-734
2009
Rattus norvegicus
Kovar, J.; Lenicek, V.; Zimolova, M.; Vitek, L.; Jirsa, M.; Pitha, P.
Regulation of diurnal variation of cholesterol 7alpha-hydroxylase (CYP7A1) activity in healthy subjects
Physiol. Res.
59
233-238
2010
Homo sapiens
De Castro-Oros, I.; Pampin, S.; Cofan, M.; Mozas, P.; Pinto, X.; Salas-Salvado, J.; Rodriguez-Rey, J.C.; Ros, E.; Civeira, F.; Pocovi, M.
Promoter variant -204A>C of the cholesterol 7alpha-hydroxylase gene: Association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells
Clin. Nutr.
30
239-246
2010
Homo sapiens
Wooton-Kee, C.; Coy, D.; Athippozhy, A.; Zhao, T.; Jones, B.; Vore, M.
Mechanisms for increased expression of cholesterol 7alpha-hydroxylase (Cyp7a1) in lactating rats
Hepatology
51
277-285
2010
Rattus norvegicus
Li, T.; Owsley, E.; Matozel, M.; Hsu, P.; Novak, C.M.; Chiang, J.Y.
Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice
Hepatology
52
678-690
2010
Mus musculus, Mus musculus C57BL/6
Song, K.H.; Li, T.; Owsley, E.; Chiang, J.Y.
A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes
J. Lipid Res.
51
2223-2233
2010
Homo sapiens
Li, T.; Chanda, D.; Zhang, Y.; -SikChoi, H.; Chiang, J.
Glucose stimulates cholesterol 7 alpha-hydroxylase gene transcription in human hepatocytes
J. Lipid Res.
51
832-842
2010
Homo sapiens
Michelini, E.; Donati, M.; Aldini, R.; Cevenini, L.; Mezzanotte, L.; Nardini, P.; Foschi, C.; Zvi, I.B.; Cevenini, M.; Montagnani, M.; Marangoni, A.; Roda, A.; Cevenini, R.
Dual-color bioluminescent assay using infected HepG2 cells sheds new light on Chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7alpha-hydroxylase (CYP7A1) transcription
Anal. Biochem.
430
92-96
2012
Homo sapiens
Li, T.; Matozel, M.; Boehme, S.; Kong, B.; Nilsson, L.M.; Guo, G.; Ellis, E.; Chiang, J.Y.
Overexpression of cholesterol 7alpha-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis
Hepatology
53
996-1006
2011
Rattus norvegicus (P18125)
Li, T.; Francl, J.M.; Boehme, S.; Chiang, J.Y.
Regulation of cholesterol and bile acid homeostasis by the cholesterol 7alpha-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice
Hepatology
58
1111-1121
2013
Homo sapiens, Rattus norvegicus (P18125)
Shinkyo, R.; Xu, L.; Tallman, K.A.; Cheng, Q.; Porter, N.A.; Guengerich, F.P.
Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate
J. Biol. Chem.
286
33021-33028
2011
Homo sapiens
Kawase, A.; Yamada, A.; Gamou, Y.; Tahara, C.; Takeshita, F.; Murata, K.; Matsuda, H.; Samukawa, K.; Iwaki, M.
Increased effects of ginsenosides on the expression of cholesterol 7alpha-hydroxylase but not the bile salt export pump are involved in cholesterol metabolism
J. Nat. Med.
67
545-553
2013
Rattus norvegicus
Frank, D.J.; Waddling, C.A.; La, M.; Ortiz de Montellano, P.R.
Cytochrome P450 125A4, the third cholesterol C-26 hydroxylase from Mycobacterium smegmatis
Biochemistry
54
6909-6916
2015
Mycolicibacterium smegmatis
Krishnamurthy, K.; Glaser, S.; Alpini, G.; Cardounel, A.J.; Liu, Z.; Ilangovan, G.
Heat shock factor-1 knockout enhances cholesterol 7alpha hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis
Cardiovasc. Res.
111
74-83
2016
Mus musculus (Q64505)
Chow, E.C.; Magomedova, L.; Quach, H.P.; Patel, R.; Durk, M.R.; Fan, J.; Maeng, H.J.; Irondi, K.; Anakk, S.; Moore, D.D.; Cummins, C.L.; Pang, K.S.
Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol
Gastroenterology
146
1048-1059
2014
Homo sapiens (P22680), Homo sapiens, Mus musculus (Q64505), Mus musculus, Mus musculus C57BL/6 (Q64505)
Tempel, W.; Grabovec, I.; MacKenzie, F.; Dichenko, Y.V.; Usanov, S.A.; Gilep, A.A.; Park, H.W.; Strushkevich, N.
Structural characterization of human cholesterol 7alpha-hydroxylase
J. Lipid Res.
55
1925-1932
2014
Homo sapiens (P22680), Homo sapiens
Fu, Z.D.; Cui, J.Y.; Klaassen, C.D.
Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice
J. Lipid Res.
55
2576-2586
2014
Mus musculus (Q64505), Mus musculus C57BL/6 (Q64505)
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