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Disease on EC 1.14.14.23 - cholesterol 7alpha-monooxygenase

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DISEASE
TITLE OF PUBLICATION
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Adenoma
Genetic polymorphism of cholesterol 7alpha-hydroxylase (CYP7A1) and colorectal adenomas: Self Defense Forces Health Study.
Risk modification of colorectal adenoma by CYP7A1 polymorphisms and the role of bile acid metabolism in carcinogenesis.
Adenoviridae Infections
Expression of human cholesterol 7alpha-hydroxylase in atherosclerosis-susceptible mice via adenovirus infection.
Adrenoleukodystrophy
Case report of dysregulation of primary bile acid synthesis in a family with X-linked adrenoleukodystrophy.
Arteriosclerosis
Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene.
Ascorbic Acid Deficiency
Effect of dietary ascorbic acid, cholesterol and PCB on cholesterol and bile acid metabolism in a rat mutant unable to synthesize ascorbic acid.
Atherosclerosis
Cholesterol 7alpha-hydroxylase influences the expression of hepatic apoA-I in two inbred mouse strains displaying different susceptibilities to atherosclerosis and in hepatoma cells.
Competitive inhibition of hepatic sterol 27-hydroxylase by sitosterol: decreased activity in sitosterolemia.
CYP7A1 promoter polymorphism -203A>C affects bile salt synthesis rate in patients after ileal resection.
Downregulation of Cyp7a1 by Cholic Acid and Chenodeoxycholic Acid in Cyp27a1/ApoE Double Knockout Mice: Differential Cardiovascular Outcome.
Effect of GBOT on blood lipid and blood glucose metabolism in rats with atherosclerosis.
Effects of dipeptides having a C-terminal lysine on the cholesterol 7alpha-hydroxylase mRNA level in HepG2 cells.
Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease.
Genetic variation in the rate-limiting enzyme in cholesterol catabolism (cholesterol 7alpha-hydroxylase) influences the progression of atherosclerosis and risk of new clinical events.
Heat shock factor-1 knockout enhances cholesterol 7?-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis.
Hepatic cholesterol and bile acid synthesis, low-density lipoprotein receptor function, and plasma and fecal sterol levels in mice: effects of apolipoprotein E deficiency and probucol or phytosterol treatment.
Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice.
Improved assay of hepatic microsomal cholesterol 7 alpha-hydroxylase activity by the use of hydroxypropyl-beta-cyclodextrin and an NADPH-regenerating system.
Loss of small heterodimer partner expression in the liver protects against dyslipidemia.
Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects.
[Effects of electroacupuncture on CYP7A1 expression in liver of rabbits with atherosclerosis].
Biliary Atresia
Altered hepatobiliary gene expressions in PFIC1: ATP8B1 gene defect is associated with CFTR downregulation.
CYP7A1 expression in hepatocytes is retained with upregulated fibroblast growth factor 19 in pediatric biliary atresia.
Intestinal synthesis and secretion of bile salts as an adaptation to developmental biliary atresia in the sea lamprey.
Biliary Fistula
Effect of cholylsarcosine on hepatic cholesterol and bile acid synthesis and bile secretion in rats.
Failure of intravenous infusion of taurocholate to down-regulate cholesterol 7 alpha-hydroxylase in rats with biliary fistulas.
Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat.
Brain Death
FGF15 improves outcomes after brain dead donor liver transplantation with steatotic and non-steatotic grafts in rats.
Carcinogenesis
Association between CYP7A1 and the risk of proximal colon cancer in Japanese.
Genetic polymorphism in cytochrome P450 7A1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.
Risk modification of colorectal adenoma by CYP7A1 polymorphisms and the role of bile acid metabolism in carcinogenesis.
Carcinoma, Hepatocellular
A distinct thyroid hormone response element mediates repression of the human cholesterol 7alpha-hydroxylase (CYP7A1) gene promoter.
Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid.
ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1.
Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7alpha-hydroxylase.
Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4.
Cholesterol 7alpha-hydroxylase influences the expression of hepatic apoA-I in two inbred mouse strains displaying different susceptibilities to atherosclerosis and in hepatoma cells.
Cholesterol and hepatic lipoprotein assembly and secretion.
Coordinate regulation of lipogenesis, the assembly and secretion of apolipoprotein B-containing lipoproteins by sterol response element binding protein 1.
Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice.
Enhancing effect of taurine on CYP7A1 mRNA expression in Hep G2 cells.
Expression of cholesterol 7alpha-hydroxylase restores bile acid synthesis in McArdle RH7777 cells.
Free fatty acids repress SHP activation and adiponectin counteracts bile acid induced liver injury in super-obese patients with NASH.
Green tea catechin enhances cholesterol 7alpha-hydroxylase gene expression in HepG2 cells.
HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).
Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7alpha-hydroxylase.
Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Morris hepatoma 7800 after intravenous injection of mevalonic acid.
Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7?-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression.
MiRNA-17 encoded by the miR-17-92 cluster increases the potential for steatosis in hepatoma cells by targeting CYP7A1.
NO-1886 suppresses diet-induced insulin resistance and cholesterol accumulation through STAT5-dependent upregulation of IGF-1 and CYP7A1.
One or more labile proteins regulate the stability of chimeric mRNAs containing the 3'-untranslated region of cholesterol-7alpha -hydroxylase mRNA.
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner.
Proteasome inhibition protects against diet-induced gallstone formation through modulation of cholesterol and bile acid homeostasis.
Rat hepatoma L35 cells, a liver-differentiated cell line, display resistance to bile acid repression of cholesterol 7 alpha-hydroxylase.
Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice.
Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.
The atypical interaction of peroxisome proliferator-activated receptor alpha with liver X receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha-hydroxylase gene promoter.
The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII.
The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated receptor alpha heterodimer.
Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1.
Transcriptional induction of cholesterol 7alpha-hydroxylase by dexamethasone in L35 hepatoma cells requires sulfhydryl reducing agents.
Cardiovascular Diseases
Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7?-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression.
Pharmacogenomics and drug response in cardiovascular disorders.
Cholelithiasis
ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease.
Association of Common Single Nucleotide Polymorphisms of Candidate Genes with Gallstone Disease: A Meta-Analysis.
Cholelithiasis induced in the Syrian hamster: evidence for an intramucinous nucleating process and down regulation of cholesterol 7 alpha-hydroxylase (CYP7) gene by medroxyprogesterone.
Cholesterol 7alpha-Hydrolase (CYP7A1) c.-278A>C Promoter Polymorphism in Gallstone Disease Patients.
Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration.
CYP7A1 (-204 A>C; rs3808607 and -469 T>C; rs3824260) promoter polymorphisms and risk of gallbladder cancer in North Indian population.
Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis.
Genetic variants in CYP7A1 and risk of myocardial infarction and symptomatic gallstone disease.
Hepatic microsomal activities of cholesterol 7 alpha-hydroxylase and 3-hydroxy-3-methylglutaryl-CoA reductase in the prairie dog. An animal model for cholesterol gallstone disease.
Improved assay of hepatic microsomal cholesterol 7 alpha-hydroxylase activity by the use of hydroxypropyl-beta-cyclodextrin and an NADPH-regenerating system.
Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene.
Role of genetic variant A-204C of cholesterol 7alpha-hydroxylase (CYP7A1) in susceptibility to gallbladder cancer.
The plasma level of 7 alpha-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7 alpha-hydroxylase in man.
Cholestasis
A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene.
Bile salts regulate CYP7A1 expression and elicit a fibrotic response and abnormal lipid production in 3D liver microtissues.
Cholesterol 7-hydroxylase knockout mouse: a model for monohydroxy bile acid-related neonatal cholestasis.
Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease.
Hepatic adenine nucleotides and microsomal cholesterol 7 alpha-hydroxylase activity in the obstructed and freely draining lobes of the liver after selective bile duct obstruction.
Impaired Hepatic Adaptation to Chronic Cholestasis induced by Primary Sclerosing Cholangitis.
Suppression of bile acid synthesis, but not of hepatic cholesterol 7alpha-hydroxylase expression, by obstructive cholestasis in humans.
Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats.
The effects, underlying mechanism and interactions of dexamethasone exposure during pregnancy on maternal bile acid metabolism.
The ileum-liver Farnesoid X Receptor signaling axis mediates the compensatory mechanism of 17?-ethynylestradiol-induced cholestasis via increasing hepatic biosynthesis of chenodeoxycholic acids in rats.
[Effect of geniposidic acid on SHP-LRH-1 signaling pathway in cholestasis rats].
Cholestasis, Intrahepatic
Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes.
[Expressions of SHP and CYP7A1 in pregnant rats with intrahepatic cholestasis]
cholesterol 7alpha-monooxygenase deficiency
Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding.
Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background impairs very-low-density lipoprotein production.
Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol.
Human CYP7A1 deficiency: progress and enigmas.
Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice.
Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice.
Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders.
Coinfection
Hepatic miRNA expression reprogrammed by Plasmodium chabaudi malaria.
Colitis
Bile acid malabsorption is associated with diarrhea in acute phase of colitis.
Bile synthesis in rat models of inflammatory bowel diseases.
Colonic Neoplasms
Association between CYP7A1 and the risk of proximal colon cancer in Japanese.
Genetic polymorphism in cytochrome P450 7A1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.
Genetic polymorphism of cholesterol 7alpha-hydroxylase (CYP7A1) and colorectal adenomas: Self Defense Forces Health Study.
Colorectal Neoplasms
Association between CYP7A1 and the risk of proximal colon cancer in Japanese.
Genetic polymorphism in cytochrome P450 7A1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.
Genetic polymorphism of cholesterol 7alpha-hydroxylase (CYP7A1) and colorectal adenomas: Self Defense Forces Health Study.
Coronary Artery Disease
CYP7A1 gene polymorphism located in the 5' upstream region modifies the risk of coronary artery disease.
Genetic variation in the rate-limiting enzyme in cholesterol catabolism (cholesterol 7alpha-hydroxylase) influences the progression of atherosclerosis and risk of new clinical events.
Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7?-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression.
The relationship between CYP7A1 polymorphisms, coronary artery disease & serum lipid markers.
Coronary Disease
Guinea pigs as models to study the hypocholesterolemic effects of drugs.
Diabetes Mellitus
Association between cytochrome P450 promoter polymorphisms and ischemic stroke.
Correlation between the decrease of cholesterol efflux from macrophages in patients with type II diabetes mellitus and down-regulated CYP7A1 expression.
How the cytochrome 7a1 (CYP7A1) and ATP-binding cassette G8 (ABCG8) genetic variants affect atorvastatin response among type 2 diabetic patients attending the University of Jordan Hospital.
Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7?-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression.
Diabetes Mellitus, Type 2
Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes.
Dyslipidemias
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.
Loss of small heterodimer partner expression in the liver protects against dyslipidemia.
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Pleiotropic effects of lipid genes on plasma glucose, HbA1c and HOMA-IR levels.
Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice.
[CYP7A1 gene polymorphism and the characteristics of dyslipidemias in patients with nonalcoholic fatty liver disease concurrent with hypothyroidism].
[Statin pharmacokinetics]
Fatty Liver
Attenuation of fatty liver and prevention of hypercholesterolemia by extract of Curcuma longa through regulating the expression of CYP7A1, LDL-receptor, HO-1, and HMG-CoA reductase.
Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.
Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice.
Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease.
Effects of sanshoamides and capsaicinoids on plasma and liver lipid metabolism in hyperlipidemic rats.
Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease.
Low-level expression of cholesterol 7 ?-hydroxylase is associated with the formation of goose fatty liver.
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
MiRNA-17 encoded by the miR-17-92 cluster increases the potential for steatosis in hepatoma cells by targeting CYP7A1.
Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression.
Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression.
Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats.
Pyrazinamide alleviates rifampin-induced steatohepatitis in mice by regulating the activities of cholesterol-activated 7?-hydroxylase and lipoprotein lipase.
Regulation of Cholesterol Metabolism in Liver: Link to NAFLD and Impact of n-3 PUFAs.
Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice.
[CYP7A1 gene polymorphism and the characteristics of dyslipidemias in patients with nonalcoholic fatty liver disease concurrent with hypothyroidism].
Gallbladder Neoplasms
CYP7A1 (-204 A>C; rs3808607 and -469 T>C; rs3824260) promoter polymorphisms and risk of gallbladder cancer in North Indian population.
Role of genetic variant A-204C of cholesterol 7alpha-hydroxylase (CYP7A1) in susceptibility to gallbladder cancer.
Gallstones
Accumulation of 7 alpha-hydroxycholesterol in liver tissue of patients with cholesterol gallstones.
Aging per se is an independent risk factor for cholesterol gallstone formation in gallstone susceptible mice.
Antilithiasic effect of beta-cyclodextrin in LPN hamster: comparison with cholestyramine.
Circulating markers for biosynthesis of cholesterol and bile acids are not depressed in asymptomatic gallstone subjects.
Concentration of unsulfated lithocholic acid in portal and systemic venous plasma: evidence that lithocholic acid does not down regulate the hepatic cholesterol 7 alpha-hydroxylase activity in gallstone patients.
CYP7A1 (-204 A>C; rs3808607 and -469 T>C; rs3824260) promoter polymorphisms and risk of gallbladder cancer in North Indian population.
Decreased expression of cholesterol 7alpha hydroxylase and altered bile acid metabolism in Apobec-1 -/- mice leads to increased gallstone susceptibility.
Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis.
Deoxycholic acid treatment in patients with cholesterol gallstones: failure to detect a suppression of cholesterol 7alpha-hydroxylase activity.
Effect of chenodeoxycholic acid and phenobarbital on the rate-limiting enzymes of hepatic cholesterol and bile acid synthesis in patients with gallstones.
Effect of dietary taurine on cholesterol 7 alpha-hydroxylase activity in the liver of mice fed a lithogenic diet.
Estrogen enhances dietary cholesterol induction of saturated bile in the hamster.
Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression.
Hepatic cholesterol and bile acid metabolism in subjects with gallstones: comparative effects of short erm feeding of chenodeoxycholic and ursodeoxycholic acid.
Hepatic cholesterol and bile acid synthesis in Japanese patients with cholesterol gallstones.
Hepatic cholesterol metabolism in cholesterol gallstone disease.
Hepatic cholesterol metabolism in patients with cholesterol gallstones: enhanced intracellular transport of cholesterol.
Hepatic cholesterol metabolism in patients with gallstones.
Hepatic microsomal activities of cholesterol 7 alpha-hydroxylase and 3-hydroxy-3-methylglutaryl-CoA reductase in the prairie dog. An animal model for cholesterol gallstone disease.
Hypothyroidism Increases Cholesterol Gallstone Prevalence in Mice by Elevated Hydrophobicity of Primary Bile Acids.
Increased bile acid concentration in liver tissue with cholesterol gallstone disease.
Influence of bezafibrate on hepatic cholesterol metabolism in gallstone patients: reduced activity of cholesterol 7 alpha-hydroxylase.
Modulation of cholesterol 7 alpha-hydroxylase activity by nonspecific lipid transfer protein in human liver--possibly altered regulation of its cytosolic level in patients with gallstones.
On the saturation of the cholesterol 7 alpha-hydroxylase in human liver microsomes.
Protective Effects of Yinchenhao Decoction on Cholesterol Gallstone in Mice Fed a Lithogenic Diet by Regulating LXR, CYP7A1, CYP7B1, and HMGCR Pathways.
Role of genetic variant A-204C of cholesterol 7alpha-hydroxylase (CYP7A1) in susceptibility to gallbladder cancer.
Role of osteopontin in diet-induced brown gallstone formation in rats.
Rowachol and ursodeoxycholic acid in hamsters with cholesterol gallstones.
Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation.
The G protein-coupled receptor G2A: involvement in hepatic lipid metabolism and gallstone formation in mice.
Weaving betaKlotho into bile acid metabolism.
[Effects of Shengqing Capsules on cholelithiasis-related genes in guinea pigs]
Hepatitis
A Network Pharmacology Study of the Molecular Mechanisms of Hypericum japonicum in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model.
Hepatoblastoma
Combining intracellular and secreted bioluminescent reporter proteins for multicolor cell-based assays.
Dual-color bioluminescent assay using infected HepG2 cells sheds new light on Chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7?-hydroxylase (CYP7A1) transcription.
Hep G2 cells: a model for studies on regulation of human cholesterol 7alpha-hydroxylase at the molecular level.
The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated receptor alpha heterodimer.
Hepatomegaly
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.
Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4.
Homozygous Familial Hypercholesterolemia
Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders.
Hypercholesterolemia
Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.
Attenuation of fatty liver and prevention of hypercholesterolemia by extract of Curcuma longa through regulating the expression of CYP7A1, LDL-receptor, HO-1, and HMG-CoA reductase.
Bile salts regulate CYP7A1 expression and elicit a fibrotic response and abnormal lipid production in 3D liver microtissues.
Cholesterol and bile acid synthesis during total parenteral nutrition with and without lipid emulsion in the rat.
Competitive inhibition of hepatic sterol 27-hydroxylase by sitosterol: decreased activity in sitosterolemia.
Cyp7a1 is continuously increased with disrupted Fxr-mediated feedback inhibition in hypercholesterolemic TALLYHO/Jng mice.
Decreased protein and gene expression of hepatic cholesterol 7a-hydroxylase associated with dilated endoplasmic reticulum in chronic hypothyroid rats.
Dietary chitosan enhances hepatic CYP7A1 activity and reduces plasma and liver cholesterol concentrations in diet-induced hypercholesterolemia in rats.
Differences in expression of cholesterol 7alpha-hydroxylase between PHHC and Wistar rats.
Effect of Cytochrome P450 7A1 (CYP7A1) Polymorphism on Lipid Responses to Simvastatin Treatment.
Effect of sitosterol on the rate-limiting enzymes in cholesterol synthesis and degradation.
Effects of dipeptides having a C-terminal lysine on the cholesterol 7alpha-hydroxylase mRNA level in HepG2 cells.
Effects of gender on hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and LDL receptor in hereditary analbuminemia.
Effects of HMG-CoA reductase inhibition on hepatic expression of key cholesterol-regulatory enzymes and receptors in nephrotic syndrome.
Gemfibrozil reduces non-high-density lipoprotein cholesterol in exogenously hypercholesterolemic (ExHC) rats fed a high-cholesterol diet.
Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis.
HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LCAT, ACAT, LDL receptor, and SRB-1 in hereditary analbuminemia.
HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X.
Hypocholesterolemic action of pre-germinated brown rice in hepatoma-bearing rats.
Increasing hepatic cholesterol 7alpha-hydroxylase reduces plasma cholesterol concentrations in normocholesterolemic and hypercholesterolemic rabbits.
Inhibition of miR-27b Regulates Lipid Metabolism in Skeletal Muscle of Obese Rats During Hypoxic Exercise by Increasing PPAR? Expression.
Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis.
Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice.
Lentinus edodes promotes fat removal in hypercholesterolemic mice.
Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene.
Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet.
Premature weaning-induced changes of cholesterol metabolism in guinea pigs.
Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders.
Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid.
Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits.
Superiority of dietary safflower oil over olive oil in lowering serum cholesterol and increasing hepatic mRnas for the LDL receptor and cholesterol 7alpha-hydroxylase in exogenously hypercholesterolemic (exHC) rats.
The effect of colesevelam treatment on bile acid and lipid metabolism and glycemic control in healthy men.
Thyroid hormone receptor beta-deficient mice show complete loss of the normal cholesterol 7alpha-hydroxylase (CYP7A) response to thyroid hormone but display enhanced resistance to dietary cholesterol.
Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease.
Transgenic expression of CYP7A1 in LDL receptor-deficient mice blocks diet-induced hypercholesterolemia.
Up-regulation of acyl-coenzyme A:cholesterol acyltransferase (ACAT) in nephrotic syndrome.
Hyperglycemia
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity.
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Hyperhomocysteinemia
Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease.
Hyperinsulinism
NO-1886 suppresses diet-induced insulin resistance and cholesterol accumulation through STAT5-dependent upregulation of IGF-1 and CYP7A1.
Hyperlipidemias
A new TCM formula FTZ lowers serum cholesterol by regulating HMG-CoA reductase and CYP7A1 in hyperlipidemic rats.
Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia.
Cassia auriculata flower extract attenuates hyperlipidemia in male Wistar rats by regulating the hepatic cholesterol metabolism.
Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease.
Enterococcus faecium WEFA23 from infants lessens high-fat-diet-induced hyperlipidemia via cholesterol 7-alpha-hydroxylase gene by altering the composition of gut microbiota in rats.
Glucomannan and glucomannan plus spirulina added to pork significantly block dietary cholesterol effects on lipoproteinemia, arylesterase activity, and CYP7A1 expression in Zucker fa/fa rats.
HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X.
Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.
Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7alpha-hydroxylase.
Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats.
Regulation of Cholesterol Metabolism in Liver: Link to NAFLD and Impact of n-3 PUFAs.
Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.
[Intervention of Huayu Qutan Recipe on liver SREBP-2 signal pathway of hyperlipidemia rats of pi deficiency syndrome].
Hyperlipoproteinemia Type II
Genes Potentially Associated with Familial Hypercholesterolemia.
No genetic linkage or molecular evidence for involvement of the PCSK9, ARH or CYP7A1 genes in the Familial Hypercholesterolemia phenotype in a sample of Danish families without pathogenic mutations in the LDL receptor and apoB genes.
Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders.
Hypersensitivity
The nuclear matrix protein CDP represses hepatic transcription of the human cholesterol-7alpha hydroxylase gene.
Hypertension
Biochemical and morphological characterization of spontaneously hypertensive hyperlipidaemic rats.
CYP7A1 genotypes and haplotypes associated with hypertension in an obese Han Chinese population.
HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X.
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Hyperthyroidism
Cholesterol 7 alpha-hydroxylase activity in hypothyroidism and hyperthyroidism in humans.
Effect of modification of thyroid function on cholesterol 7 alpha-hydroxylation in rat liver.
Regulation of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) by thyroid hormone in transgenic mice.
Hypertriglyceridemia
Common genetic variants contribute to primary hypertriglyceridemia without differences between familial combined hyperlipidemia and isolated hypertriglyceridemia.
Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene.
[Association between cholesterol 7alpha-hydroxylase -204A/C gene polymorphism and endogenous hypertriglyceridemia in Chinese]
Hypothyroidism
Cholesterol 7 alpha-hydroxylase activity in hypothyroidism and hyperthyroidism in humans.
Decreased protein and gene expression of hepatic cholesterol 7a-hydroxylase associated with dilated endoplasmic reticulum in chronic hypothyroid rats.
Regulation of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) by thyroid hormone in transgenic mice.
THYROID-STIMULATING HORMONE LEVELS ARE INVERSELY ASSOCIATED WITH SERUM TOTAL BILE ACID LEVELS: A CROSS-SECTIONAL STUDY.
[CYP7A1 gene polymorphism and the characteristics of dyslipidemias in patients with nonalcoholic fatty liver disease concurrent with hypothyroidism].
Infections
Dual-color bioluminescent assay using infected HepG2 cells sheds new light on Chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7?-hydroxylase (CYP7A1) transcription.
Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo.
Hepatic miRNA expression reprogrammed by Plasmodium chabaudi malaria.
In vivo regulation of murine CYP7A1 by HNF-6: a novel mechanism for diminished CYP7A1 expression in biliary obstruction.
Overexpression of cholesterol transporter StAR increases in vivo rates of bile acid synthesis in the rat and mouse.
PGC-1alpha activates CYP7A1 and bile acid biosynthesis.
Reciprocal regulation of farnesoid X receptor ? activity and hepatitis B virus replication in differentiated HepaRG cells and primary human hepatocytes.
Testosterone response of hepatic gene expression in female mice having acquired testosterone-unresponsive immunity to Plasmodium chabaudi malaria.
Insulin Resistance
Alteration of FXR phosphorylation and sumoylation in liver in the development of adult catch-up growth.
BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis.
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.
Hepatocyte Sortilin 1 knockout and treatment with a Sortilin 1 inhibitor reduced plasma cholesterol in Western diet-fed mice.
HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X.
Insulin-dependent suppression of cholesterol 7?-hydroxlase is a possible link between glucose and cholesterol metabolisms.
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
NO-1886 suppresses diet-induced insulin resistance and cholesterol accumulation through STAT5-dependent upregulation of IGF-1 and CYP7A1.
Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice.
Liver Cirrhosis
Chemical profile of Swertia mussotii Franch and its potential targets against liver fibrosis revealed by cross-platform metabolomics.
Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease.
The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model.
Liver Cirrhosis, Biliary
Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway.
Liver Diseases
A Network Pharmacology Study of the Molecular Mechanisms of Hypericum japonicum in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model.
A nontumorigenic variant of FGF19 treats cholestatic liver diseases.
Association of genes involved in bile acid synthesis with the progression of primary biliary cirrhosis in Japanese patients.
Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease.
Establishment of an ex Vivo Model of Nonalcoholic Fatty Liver Disease Using a Tissue-Engineered Liver.
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice.
Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver.
Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease.
Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice.
[CYP7A1 gene polymorphism and the characteristics of dyslipidemias in patients with nonalcoholic fatty liver disease concurrent with hypothyroidism].
Liver Diseases, Alcoholic
Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice.
Liver Neoplasms
Transcriptional toxicity of the Yangtze River source water on mouse (Mus musculus) detected by cDNA microarray.
Malnutrition
Undernutrition Shapes the Gut Microbiota and Bile Acid Profile in Association with Altered Gut-Liver FXR Signaling in Weaning Pigs.
Metabolic Syndrome
NO-1886 suppresses diet-induced insulin resistance and cholesterol accumulation through STAT5-dependent upregulation of IGF-1 and CYP7A1.
STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS.
methylenetetrahydrofolate dehydrogenase (nad+) deficiency
Mild Methylenetetrahydrofolate Reductase Deficiency Alters Inflammatory and Lipid Pathways in Liver.
Multiple Sclerosis
Variants in the promoter region of CYP7A1 are associated with neuromyelitis optica but not with multiple sclerosis in the Han Chinese population.
Myocardial Infarction
Genetic variants in CYP7A1 and risk of myocardial infarction and symptomatic gallstone disease.
Neoplasms
A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ mice.
Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting.
All-trans-retinoic acid improves cholestasis in ?-naphthylisothiocyanate-treated rats and Mdr2-/- mice.
Association between CYP7A1 and the risk of proximal colon cancer in Japanese.
Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7alpha-hydroxylase.
Co-administration of obeticholic acid and simvastatin protects against high-fat diet-induced non-alcoholic steatohepatitis in mice.
Corn silk extract improves cholesterol metabolism in C57BL/6J mouse fed high-fat diets.
Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway.
Posttranscriptional regulation of mRNA levels in rat liver associated with deoxycholic acid feeding.
Raw Bowl Tea (Tuocha) Polyphenol Prevention of Nonalcoholic Fatty Liver Disease by Regulating Intestinal Function in Mice.
Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP.
Role of osteopontin in diet-induced brown gallstone formation in rats.
The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors.
Tumor necrosis factor-alpha-independent downregulation of hepatic cholesterol 7alpha-hydroxylase gene in mice treated with lead nitrate.
Nephrosis
Gene expression of hepatic cholesterol 7 alpha-hydroxylase in the course of puromycin-induced nephrosis.
Nephrotic Syndrome
Studies of alteration of hepatic cholesterol metabolism in puromycin-induced nephrotic syndrome in rats.
Up-regulation of acyl-coenzyme A:cholesterol acyltransferase (ACAT) in nephrotic syndrome.
Neurocutaneous Syndromes
Unique Variant of Cerebrotendinous Xanthomatosis Presenting With Eyelid Involvement Due to Heterozygous CYP7A1 and SLC10A1 Gene Mutations.
Neuromyelitis Optica
Common CYP7A1 promoter polymorphism associated with risk of neuromyelitis optica.
Variants in the promoter region of CYP7A1 are associated with neuromyelitis optica but not with multiple sclerosis in the Han Chinese population.
Non-alcoholic Fatty Liver Disease
A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Co-Administration of Cholesterol-Lowering Probiotics and Anthraquinone from Cassia obtusifolia L. Ameliorate Non-Alcoholic Fatty Liver.
Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease.
Establishment of an ex Vivo Model of Nonalcoholic Fatty Liver Disease Using a Tissue-Engineered Liver.
Integrated Analysis of Multiple Microarray Studies to Identify Novel Gene Signatures in Non-alcoholic Fatty Liver Disease.
Lactobacillus fermentum CQPC06 in naturally fermented pickles prevents non-alcoholic fatty liver disease by stabilizing the gut-liver axis in mice.
Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease.
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver.
Raw Bowl Tea (Tuocha) Polyphenol Prevention of Nonalcoholic Fatty Liver Disease by Regulating Intestinal Function in Mice.
Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease.
[CYP7A1 gene polymorphism and the characteristics of dyslipidemias in patients with nonalcoholic fatty liver disease concurrent with hypothyroidism].
Obesity
Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.
Hepatic cholesterol accumulation ascribed to the activation of ileum Fxr-Fgf15 pathway inhibiting hepatic Cyp7a1 in high-fat diet-induced obesity rats.
Hepatocyte Sortilin 1 knockout and treatment with a Sortilin 1 inhibitor reduced plasma cholesterol in Western diet-fed mice.
HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X.
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice.
Rectal Neoplasms
Genetic polymorphism in cytochrome P450 7A1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.
Renal Insufficiency
Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7 alpha-hydroxylase in rats with subtotal nephrectomy.
Sarcoma, Avian
Expression of human cholesterol 7alpha-hydroxylase in atherosclerosis-susceptible mice via adenovirus infection.
Sepsis
On the Role of Illness Duration and Nutrient Restriction in Cholestatic Alterations that Occur During Critical Illness.
Retinoid X receptor alpha participation in dexamethasone induced rat bile acid coenzyme A-amino acid N-acyltransferase expression in septic liver.
Smith-Lemli-Opitz Syndrome
Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7alpha-hydroxylase and 27-hydroxylase activities in rat liver.
Starvation
Serum starvation improves transient transfection efficiency in differentiating embryonic stem cells.
Studies on the link between HMG-CoA reductase and cholesterol 7 alpha-hydroxylase in rat liver.
Tuberculosis
The CYP7A1 gene rs3808607 variant is associated with susceptibility of tuberculosis in Moroccan population.
Vitamin E Deficiency
Effects of vitamin E deficiency on the distribution of cholesterol in plasma lipoproteins and the activity of cholesterol 7 alpha-hydroxylase in rabbit liver.
Xanthomatosis
Competitive inhibition of bile acid synthesis by endogenous cholestanol and sitosterol in sitosterolemia with xanthomatosis. Effect on cholesterol 7 alpha-hydroxylase.
Unique Variant of Cerebrotendinous Xanthomatosis Presenting With Eyelid Involvement Due to Heterozygous CYP7A1 and SLC10A1 Gene Mutations.
Xanthomatosis, Cerebrotendinous
Unique Variant of Cerebrotendinous Xanthomatosis Presenting With Eyelid Involvement Due to Heterozygous CYP7A1 and SLC10A1 Gene Mutations.