Reference on EC 1.14.14.32 - 17alpha-hydroxyprogesterone deacetylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
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Macaca fascicularis
Burke, D.F.; Laughton, C.A.; Neidle, S.
Homology modelling of the enzyme P450 17alpha-hydroxylase/17,20-lyase-a taget for prostate cancer chemotherapy-from the crystal structure of P450BM-3
Anticancer Drug Des.
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Homo sapiens
Cloutier, M.; Fleury, A.; Courtemanche, J.; Ducharme, L.; Mason, J.I.; Lehoux, J.G.
Characterization of the adrenal cytochrome P450C17 in the hamster, a small animal model for the study of adrenal dehydroepiandrosterone biosynthesis
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Mesocricetus auratus
Gupta, M.K.; Guryev, O.L.; Auchus, R.J.
5alpha-reduced C21 steroids are substrates for human cytochrome P450c17
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2003
Homo sapiens
Gilep, A.A.; Estabrook, R.W.; Usanov, S.A.
Chimerogenesis in estimation of specificity and pathway directions for cytochrome P45017alpha catalyzed reactions
Biochemistry (Moscow)
69
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2004
Cavia porcellus (Q64410)
Akhtar, M.K.; Kelly, S.L.; Kaderbhai, M.A.
Cytochrome b5 modulation of 17alpha hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis
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2005
Homo sapiens
Fernandes, D.; Bebianno, M.J.; Porte, C.
Mitochondrial metabolism of 17alpha-hydroxyprogesterone in male sea bass (Dicentrarchus labrax): a potential target for endocrine disruptors
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Dicentrarchus labrax
Kolar, N.W.; Swart, A.C.; Mason, J.I.; Swart, P.
Functional expression and characterisation of human cytochrome P45017alpha in Pichia pastoris
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129
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Homo sapiens
Martin, R.M.; Oliveira, P.S.; Costa, E.M.; Arnhold, I.J.; Mendonca, B.B.
Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a homozygous 25 BP duplication (NT 4157-4181) at exon 5 in the CYP17 resulting in a premature stop codon predicted by molecular modeling
Arq. Bras. Endocrinol. Metabol.
52
1317-1320
2008
Homo sapiens
Nguyen, A.D.; Corbin, C.J.; Pattison, J.C.; Bird, I.M.; Conley, A.J.
The developmental increase in adrenocortical 17,20-lyase activity (biochemical adrenarche) is driven primarily by increasing cytochrome b5 in neonatal rhesus macaques
Endocrinology
150
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2009
Macaca mulatta
Hershkovitz, E.; Parvari, R.; Wudy, S.A.; Hartmann, M.F.; Gomes, L.G.; Loewental, N.; Miller, W.L.
Homozygous mutation G539R in the gene for P450 oxidoreductase in a family previously diagnosed as having 17,20-lyase deficiency
J. Clin. Endocrinol. Metab.
93
3584-3588
2008
Homo sapiens
Bhangoo, A.; Aisenberg, J.; Chartoffe, A.; Ten, S.; Wallerstein, R.J.; Wolf, R.; Auchus, R.J.
Novel mutation in cytochrome P450c17 causes complete combined 17alpha-hydroxylase/17,20-lyase deficiency
J. Pediatr. Endocrinol. Metab.
21
185-190
2008
Homo sapiens
Shahid, I.; Patel, C.H.; Dhanani, S.; Owen, C.P.; Ahmed, S.
Synthesis, biochemical evaluation of a range of potent 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-Hydroxylase/17,20-Lyase (P45017alpha)
J. Steroid Biochem. Mol. Biol.
110
18-29
2008
Rattus norvegicus
Vasaitis, T.; Belosay, A.; Schayowitz, A.; Khandelwal, A.; Chopra, P.; Gediya, L.K.; Guo, Z.; Fang, H.B.; Njar, V.C.; Brodie, A.M.
Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer
Mol. Cancer Ther.
7
2348-2357
2008
Homo sapiens
Bruno, R.D.; Gover, T.D.; Burger, A.M.; Brodie, A.M.; Njar, V.C.
17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response
Mol. Cancer Ther.
7
2828-2836
2008
Homo sapiens
Ondre, D.; Woelfling, J.; Ivanyi, Z.; Schneider, G.; Toth, I.; Szecsi, M.; Julesz, J.
Neighboring group participation Part 17 Stereoselective synthesis of some steroidal 2-oxazolidones, as novel potential inhibitors of 17alpha-hydroxylase-C(17,20)-lyase
Steroids
73
1375-1384
2008
Rattus norvegicus
Shackleton, C.H.; Neres, M.S.; Hughes, B.A.; Stewart, P.M.; Kater, C.E.
17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites
Steroids
73
652-656
2008
Homo sapiens
Ahmed, S.; Shahid, I.; Dhanani, S.; Owen, C.P.
Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha))
Bioorg. Med. Chem. Lett.
19
4698-4701
2009
Rattus norvegicus
Chen, C.F.; Wen, H.S.; Wang, Z.P.; He, F.; Zhang, J.R.; Chen, X.Y.; Jin, G.X.; Shi, B.; Shi, D.; Yang, Y.P.; Li, J.F.; Qi, B.X.; Li, N.
Cloning and expression of P450c17-I (17alpha-hydroxylase/17,20-lyase) in brain and ovary during gonad development in Cynoglossus semilaevis
Fish Physiol. Biochem.
36
1001-1012
2010
Cynoglossus semilaevis (B2D2I4), Cynoglossus semilaevis
Rosa, S.; Steigert, M.; Lang-Muritano, M.; lAllemand, D.; Schoenle, E.J.; Biason-Lauber, A.
Clinical, genetic and functional characteristics of three novel CYP17A1 mutations causing combined 17alpha-hydroxylase/17,20-lyase deficiency
Horm. Res. Paediatr.
73
198-204
2010
Homo sapiens
Zhang, H.; Sheng, X.; Hu, X.; Li, X.; Xl, H.; Zhang, M.; Li, B.; Xu, M.; Weng, Q.; Zhang, Z.; Taya, K.
Seasonal changes in spermatogenesis and immunolocalization of cytochrome P450 17alpha-hydroxylase/c17-20 lyase and cytochrome P450 aromatase in the wild male ground squirrel (Citellus dauricus Brandt)
J. Reprod. Dev.
56
297-302
2010
Spermophilus dauricus
Liu, Y.; Pocivavsek, A.; Papadopoulos, V.
Dehydroepiandrosterone formation is independent of cytochrome P450 17alpha-hydroxylase/17, 20 lyase activity in the mouse brain
J. Steroid Biochem. Mol. Biol.
115
86-90
2009
Mus musculus, Mus musculus C57BL/6
Katsumata, N.; Ogawa, E.; Fujiwara, I.; Fujikura, K.
Novel CYP17A1 mutation in a Japanese patient with combined 17alpha-hydroxylase/17,20-lyase deficiency
Metab. Clin. Exp.
59
275-278
2009
Homo sapiens
Li, Y.; Liang, X.; Wei, L.; Xiong, Y.; Yang, X.; Shi, H.; Yang, Z.
Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo
Reprod. Biol. Endocrinol.
7
73-80
2009
Rattus norvegicus
Ondre, D.; Woelfling, J.; Toth, I.; Szecsi, M.; Julesz, J.; Schneider, G.
Steroselective synthesis of some steroidal oxazolines, as novel potential inhibitors of 17alpha-hydroxylase-C17,20-lyase
Steroids
74
1025-1032
2009
Rattus norvegicus
Ivanyi, Z.; Woelfling, J.; Goerbe, T.; Szecsi, M.; Wittmann, T.; Schneider, G.
Synthesis of regioisomeric 17beta-N-phenylpyrazolyl steroid derivatives and their inhibitory effect on 17alpha-hydroxylase/C(17,20)-lyase
Steroids
75
450-456
2010
Rattus norvegicus
Neto, A.C.; Ball, B.A.; Browne, P.; Conley, A.J.
Cellular localization of androgen synthesis in equine granulosa-theca cell tumors: Immunohistochemical expression of 17alpha-hydroxylase/17,20-lyase cytochrome P450
Theriogenology
74
393-401
2010
Equus sp.
Frank, E.; Mucsi, Z.; Szcsi, M.; Zupk, I.; Wlfling, J.; Schneider, G.
Intramolecular approach to some new D-ring-fused steroidal isoxazolidines by 1,3-dipolar cycloaddition: synthesis, theoretical and in vitro pharmacological studies
New J. Chem.
34
2671-2681
2010
Rattus norvegicus
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Wlfling, J.; Oravecz, E.A.; Ondr, D.; Mernyk, E.; Schneider, G.; Tth, I.; Szcsi, M.; Julesz, J.
Stereoselective synthesis of some 17beta-dihydrooxazinyl steroids, as novel presumed inhibitors of 17alpha-hydroxylase-C17,20-lyase
Steroids
71
809-816
2006
Rattus norvegicus
Shumyantseva, V.; Bulko, T.; Misharin, A.; Archakov, A.
Screening of potential substrates or inhibitors of cytochrome P450 17A1 (CYP17A1) by electrochemical methods
Biochemistry (Moscow) Suppl. Ser. B
57
402-409
2011
Homo sapiens
Gilep, A.A.; Sushko, T.A.; Usanov, S.A.
At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17
Biochim. Biophys. Acta
1814
200-209
2011
Papio sp., Bison bison, Bos taurus, Capra hircus, Cavia porcellus, Equus caballus, Felis catus, Ovis aries, Mus musculus, Pan troglodytes, Rattus norvegicus, Sus scrofa, Homo sapiens (P05093)
Stefanachi, A.; Favia, A.; Nicolotti, O.; Leonetti, F.; Pisani, L.; Catto, M.; Zimmer, C.; Hartmann, R.; Carotti, A.
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-alpha-hydroxylase/C17-20 lyase
J. Med. Chem.
54
1613-1625
2011
Homo sapiens
Manca, P.; Mulliri, G.; Burrai, G.P.; Pirino, S.; Mameli, O.
Immunohistochemical localisation and molecular expression of the steroidogenic enzyme cytochrome p450 17alpha-hydroxylase/c(17,20)-lyase in the vestibular nuclei of adult male rats
J. Neuroendocrinol.
23
444-449
2011
Rattus norvegicus
Khatri, Y.; Gregory, M.C.; Grinkova, Y.V.; Denisov, I.G.; Sligar, S.G.
Active site proton delivery and the lyase activity of human CYP17A1
Biochem. Biophys. Res. Commun.
443
179-184
2014
Homo sapiens
Kovacs, D.; Wlfling, J.; Szabo, N.; Szecsi, M.; Kovacs, I.; Zupko, I.; Frank, E.
An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17alpha-hydroxylase/C17,20-lyase
Eur. J. Med. Chem.
70
649-660
2013
Homo sapiens, Rattus norvegicus
Roelofs, M.J.; Piersma, A.H.; van den Berg, M.; van Duursen, M.B.
The relevance of chemical interactions with CYP17 enzyme activity: assessment using a novel in vitro assay
Toxicol. Appl. Pharmacol.
268
309-317
2013
Sus scrofa, Homo sapiens (P05093), Homo sapiens
Szabo, N.; Ajdukovic, J.J.; Djurendic, E.A.; Sakac, M.N.; Ignath, I.; Gardi, J.; Mahmoud, G.; Klisuric, O.R.; Jovanovic-Santa, S.; Penov Gasi, K.M.; Szecsi, M.
Determination of 17alpha-hydroxylase-C17,20-lyase (P45017alpha) enzyme activities and their inhibition by selected steroidal picolyl and picolinylidene compounds
Acta Biol. Hung.
66
41-51
2015
Rattus norvegicus
Yoshimoto, F.K.; Auchus, R.J.
The diverse chemistry of cytochrome P450 17A1 (P450c17, CYP17A1)
J. Steroid Biochem. Mol. Biol.
151
52-65
2015
Homo sapiens (P05093), Homo sapiens
Kuzikov, A.V.; Dugin, N.O.; Stulov, S.V.; Shcherbinin, D.S.; Zharkova, M.S.; Tkachev, Y.V.; Timofeev, V.P.; Veselovsky, A.V.; Shumyantseva, V.V.; Misharin, A.Y.
Novel oxazolinyl derivatives of pregna-5,17(20)-diene as 17alpha-hydroxylase/17,20-lyase (CYP17A1) inhibitors
Steroids
88
66-71
2014
Homo sapiens
Mak, P.J.; Gregory, M.C.; Sligar, S.G.; Kincaid, J.R.
Resonance Raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic ligands of CYP17
Biochemistry
53
90-100
2014
Homo sapiens (P05093)
Peng, H.M.; Im, S.C.; Pearl, N.M.; Turcu, A.F.; Rege, J.; Waskell, L.; Auchus, R.J.
Cytochrome b5 Activates the 17,20-lyase activity of human cytochrome P450 17A1 by increasing the coupling of NADPH consumption to androgen production
Biochemistry
55
4356-4365
2016
Homo sapiens (P05093), Homo sapiens
Huang, X.; Jin, J.; Shen, S.; Xia, Y.; Xu, P.; Zou, X.; Wang, H.; Yi, L.; Wang, Y.; Gao, Q.
Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line
Gynecol. Endocrinol.
32
201-205
2016
Homo sapiens
Simonov, A.N.; Holien, J.K.; Yeung, J.C.; Nguyen, A.D.; Corbin, C.J.; Zheng, J.; Kuznetsov, V.L.; Auchus, R.J.; Conley, A.J.; Bond, A.M.; Parker, M.W.; Rodgers, R.J.; Martin, L.L.
Mechanistic scrutiny identifies a kinetic role for cytochrome b5 regulation of human cytochrome P450c17 (CYP17A1, P450 17A1)
PLoS ONE
10
e0141252
2015
Homo sapiens (P05093), Homo sapiens
Gonzalez, E.; Guengerich, F.P.
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1
J. Biol. Chem.
292
13168-13185
2017
Homo sapiens (P05093), Homo sapiens
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