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Information on EC 1.14.14.57 - taurochenodeoxycholate 6alpha-hydroxylase

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IUBMB Comments
A cytochrome P-450 (heme-thiolate) protein. Requires cytochrome b5 for maximal activity. Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate. In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
CYP3A4, CYP4A21, taurochenodeoxycholate 6alpha-monooxygenase, taurochenodeoxycholic acid 6alpha-hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
lithocholate + [reduced NADPH-hemoprotein reductase] + O2 = hyodeoxycholate + [oxidized NADPH-hemoprotein reductase] + H2O
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(2)
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taurochenodeoxycholate + [reduced NADPH-hemoprotein reductase] + O2 = taurohyocholate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1)
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