Disease on EC 1.14.14.73 - albendazole monooxygenase (sulfoxide-forming)

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DISEASE
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albendazole monooxygenase (sulfoxide-forming) deficiency
Inducible CYP2J2 and Its Product 11,12-EET Promotes Bacterial Phagocytosis: A Role for CYP2J2 Deficiency in the Pathogenesis of Crohn's Disease?
Alzheimer Disease
CYP2J2 rs890293 polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese Han population.
Gene- gene interaction between CYP2J2 and PPAR -? gene on late-onset Alzheimer's disease in the eastern Chinese Han population.
Aortic Aneurysm, Abdominal
CYP2J2 Overexpression Increases EETs and Protects against Angiotensin II-Induced Abdominal Aortic Aneurysm in Mice.
Arrhythmias, Cardiac
CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy.
Asthma
Promoter polymorphism G-50T of a human CYP2J2 epoxygenase gene is associated with common susceptibility to asthma.
Atherosclerosis
CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study.
CYP2J2 Overexpression Increases EETs and Protects Against HFD-induced Atherosclerosis in ApoE-/- Mice.
CYP2J2 participates in atherogenesis by mediating cell proliferation, migration and foam cell formation.
Brain Ischemia
Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.
Breast Neoplasms
Activation of ALDH1A1 in MDA-MB-468 breast cancer cells that over-express CYP2J2 protects against paclitaxel-dependent cell death mediated by reactive oxygen species.
Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.
Carcinogenesis
A molecular design strategy to construct the near-infrared fluorescent probe for selectively sensing human cytochrome P450 2J2.
Carcinoma
Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors.
Cytochrome p450 epoxygenase promotes human cancer metastasis.
Expression of cytochrome P450 arachidonic acid epoxygenase 2J2 in human tumor tissues and cell lines.
Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells.
Potential of decursin to inhibit the human cytochrome P450 2J2 isoform.
The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation.
The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.
Carcinoma, Hepatocellular
Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation.
Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells.
Role of cytochrome P450 2J2 on cell proliferation and resistance to an anticancer agent in hepatocellular carcinoma HepG2 cells.
Carcinoma, Squamous Cell
The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.
Cardiomegaly
Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice.
CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK?2 and enhancing nuclear translocation of Akt1.
CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy.
Cardiotoxicity
Activity, Inhibition and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes.
An Emerging Pathway of Doxorubicin Cardiotoxicity Mediated through CYP2J2.
CYP2J2 Expression in Adult Ventricular Myocytes Protects Against Reactive Oxygen Species Toxicity.
Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity.
Overexpression of CYP2J2 Provides Protection against Doxorubicin Induced Cardiotoxicity.
Cardiovascular Diseases
CYP2J2 epoxygenase membrane anchor plays an important role in facilitating electron transfer from CPR.
Regulation of CYP2J2 and EET Levels in Cardiac Disease and Diabetes.
The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases.
Colitis, Ulcerative
Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression.
Coronary Artery Disease
A novel polymorphism of the CYP2J2 gene is associated with coronary artery disease in Uygur population in China.
Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease.
Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease.
Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian Patients.
Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease.
Research/review: Insights into the mutation-induced dysfunction of arachidonic acid metabolism from modeling of human CYP2J2.
Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.
Structural basis for the mutation-induced dysfunction of human CYP2J2: a computational study.
The Roles of Cytochrome P450 in Ischemic Heart Diseas.
Coronary Disease
CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study.
The -50G>T polymorphism in the promoter of the CYP2J2 gene in coronary heart disease: the Ludwigshafen Risk and Cardiovascular Health study.
The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins.
Crohn Disease
Inducible CYP2J2 and Its Product 11,12-EET Promotes Bacterial Phagocytosis: A Role for CYP2J2 Deficiency in the Pathogenesis of Crohn's Disease?
Diabetes Mellitus, Type 2
Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History.
Diabetic Cardiomyopathies
Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice.
Diabetic Nephropathies
Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice.
Dyslipidemias
CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPAR?.
Essential Hypertension
A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population.
Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension.
Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian Patients.
Glucose Intolerance
CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue.
Heart Diseases
Regulation of CYP2J2 and EET Levels in Cardiac Disease and Diabetes.
Heart Failure
CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK?2 and enhancing nuclear translocation of Akt1.
CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure.
Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling.
Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-?-induced injury.
Hematologic Diseases
CYP2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth.
Hematologic Neoplasms
Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies.
Hyperemia
Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice.
Hyperhomocysteinemia
Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation.
Hyperlipidemias
CYP2J2 overexpression ameliorates hyperlipidemia via increased fatty acid oxidation mediated by the AMPK pathway.
Hypertension
A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population.
A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk.
CYP2J2 - regulation, function and polymorphism.
CYP2J2 -50 G/T and ADRB2 G46A Gene Polymorphisms in Saudi Subjects with Hypertension.
Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension.
Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?
OS066. Intrauterine CYP2J2 expression and circulatingepoxyeicosatrienoic acid levels in preeclampsia.
Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension.
Structural basis for the mutation-induced dysfunction of human CYP2J2: a computational study.
Hypertension, Pulmonary
Gene Delivery of a Cytochrome P450 Epoxygenase Ameliorates Monocrotaline-induced Pulmonary Artery Hypertension in Rats.
Infarction, Middle Cerebral Artery
Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium.
Infection
CYP2J2 participates in atherogenesis by mediating cell proliferation, migration and foam cell formation.
Insulin Resistance
Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice.
CYP2J2 - regulation, function and polymorphism.
CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue.
CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPAR?.
Endothelium-specific CYP2J2 overexpression attenuates age-related insulin resistance.
Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History.
Kidney Failure, Chronic
Delivery of AAV2-CYP2J2 protects remnant kidney in the 5/6 nephrectomized rat via inhibition of apoptosis and fibrosis.
Leukemia
CYP2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth.
The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases.
Liver Diseases
CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice.
Myocardial Infarction
Association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms with myocardial infarction in South Indian population.
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
Haplotype analysis of the CYP2J2 gene associated with myocardial infarction in a Chinese Han population.
The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile.
Neoplasm Metastasis
[Research progress of human cytochrome P450 2J2 and its ligands].
Neoplasms
A molecular design strategy to construct the near-infrared fluorescent probe for selectively sensing human cytochrome P450 2J2.
Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.
Comparative Analysis of Peritoneum and Tumor Eicosanoids and Pathways in Advanced Ovarian Cancer.
CYP epoxygenase derived EETs: from cardiovascular protection to human cancer therapy.
CYP2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth.
Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors.
Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance.
Cytochrome p450 epoxygenase promotes human cancer metastasis.
Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.
Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.
Epoxyeicosatrienoic Acids Attenuate Reactive Oxygen Species level, Mitochondrial Dysfunction, Caspase Activation and Apoptosis in Carcinoma Cells Treated with Arsenic Trioxide.
Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-?-induced injury.
Expression of cytochrome P450 arachidonic acid epoxygenase 2J2 in human tumor tissues and cell lines.
Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation.
Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells.
Inhibition and inactivation of human CYP2J2: Implications in cardiac pathophysiology and opportunities in cancer therapy.
Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2.
OS066. Intrauterine CYP2J2 expression and circulatingepoxyeicosatrienoic acid levels in preeclampsia.
Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme.
Potential of decursin to inhibit the human cytochrome P450 2J2 isoform.
Role of cytochrome P450 2J2 on cell proliferation and resistance to an anticancer agent in hepatocellular carcinoma HepG2 cells.
Selective Inhibitors of CYP2J2 Related to Terfenadine Exhibit Activity Strongly against Human Cancers in vitro and in vivo.
The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation.
The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases.
The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.
[Research progress of human cytochrome P450 2J2 and its ligands].
Non-alcoholic Fatty Liver Disease
CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice.
Obesity
CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue.
Endothelium-specific CYP2J2 overexpression attenuates age-related insulin resistance.
Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History.
Role of pregnancy and obesity on vitamin D status, transport, and metabolism in baboons.
Pre-Eclampsia
Increased epoxyeicosatrienoic acids and reduced soluble epoxide hydrolase expression in the preeclamptic placenta.
OS066. Intrauterine CYP2J2 expression and circulatingepoxyeicosatrienoic acid levels in preeclampsia.
Proteinuria
Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.
Pulmonary Disease, Chronic Obstructive
Expression of cytochrome P450 mRNAs in Type II alveolar cells from subjects with chronic obstructive pulmonary disease.
Reperfusion Injury
Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids.
Squamous Cell Carcinoma of Head and Neck
The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.
Stroke
Association of CYP2J2 gene polymorphisms with ischemic stroke and stroke subtypes in Chinese population.
Association of CYP2J2 gene polymorphisms with ischemic stroke.
Cerebral Small Vessel Disease is Associated with Genetic Variations in CYP2J.
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
Triple Negative Breast Neoplasms
Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.
Varicose Veins
Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis.