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Information on EC 1.14.14.83 - geraniol 8-hydroxylase

for references in articles please use BRENDA:EC1.14.14.83

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IUBMB Comments

A cytochrome P-450 (heme thiolate) protein found in plants. Also hydroxylates nerol and citronellol, cf. EC 1.14.14.84, linalool 8-monooxygenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the product rather than 10-hydroxygeraniol as used by references 1-3. See prenol nomenclature Pr-1. The cloned enzyme also catalysed, but less efficiently, the 3′-hydroxylation of naringenin (cf. EC 1.14.14.82, flavonoid 3′-monooxygenase) .

The enzyme appears in viruses and cellular organisms

Synonyms
geraniol 10-hydroxylase, geraniol-10-hydroxylase, cyp76f45, monoterpene hydroxylase, cr10hgo, 10-hydroxygeraniol oxidoreductase, cyp76b6, geraniol 8-hydroxylase, cyp76b6 protein, cyp76b10, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
geraniol + [reduced NADPH-hemoprotein reductase] + O2 = (6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
nepetalactone biosynthesis, secologanin and strictosidine biosynthesis