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(3,4-dihydroxyphenyl)acetate + NADH + H+ + O2
? + NAD+ + H2O
-
-
-
-
?
2,4-dihydroxybenzoate
?
-
-
-
-
?
2,5-dihydroxyphenylacetate + ?
?
-
155% of 4-hydroxyphenylacetate activity
-
-
?
2-(4-hydroxyphenyl)ethanol + NADH + H+ + O2
? + NAD+ + H2O
-
-
-
-
?
2-phenylbutyric acid + H2
?
-
86% of 4-hydroxyphenylacetate activity
-
-
?
2-phenylpropionic acid + ?
?
-
77% of 4-hydroxyphenylacetate activity
-
-
?
3,4-dihydroxybenzoate + ?
?
-
30% of 4-hydroxyphenylacetate activity
-
-
?
3,4-dihydroxyphenylacetate + ?
?
3,4-dihydroxyphenylacetate + FAD + H2O
4-hydroxyphenylacetate + FADH2 + O2
-
-
-
-
r
3-(3,4-dihydroxyphenyl)-propanoic acid + FADH2 + O2
3-(3,4,5-trihydroxyphenyl)-propanoic acid + FAD + H2O
low activity
-
-
?
3-(4-hydroxyphenyl)-propanoic acid + FADH2 + O2
3-(3,4-dihydroxyphenyl)-propanoic acid + FAD + H2O
-
-
-
?
3-(4-hydroxyphenyl)propionate + ?
3-(3,4-dihydroxy)phenylpropionate + ?
3-hydroxyphenylacetate + FMNH2 + O2
3,4-hydroxyphenylacetate + FMN + H2O
3-hydroxyphenylacetate + NAD(P)H + O2
3,4-hydroxyphenylacetate + NAD(P)+ + H2O
3-hydroxyphenylacetate + NADH + H+ + O2
3,4-hydroxyphenylacetate + NAD+ + H2O
-
-
-
-
?
3-hydroxyphenylacetate + NADH + O2
3,4-hydroxyphenylacetate + NAD+ + H2O
4-aminobenzoate + ?
4-amino-3-hydroxybenzoate + ?
-
-
-
?
4-aminophenylacetate + ?
4-amino-3-hydroxyphenylacetate + ?
4-aminophenylacetate + FMNH2 + O2
4-amino-3,5-dihydroxyphenylacetate + FMN + H2O
-
-
-
?
4-bromophenol + NADH + H+ + O2
4-bromocatechol + NAD+ + H2O
rate of halophenol consumption 2.9 microM/min/g cell dry weight
-
-
?
4-chlorophenol + NADH + H+ + O2
4-chlorocatechol + NAD+ + H2O
rate of halophenol consumption 3.3 microM/min/g cell dry weight
-
-
?
4-coumarate + NADH + H+ + O2
? + NAD+ + H2O
-
-
-
-
?
4-coumaric acid + FADH2 + O2
caffeic acid + FAD + H2O
4-fluorophenol + NADH + H+ + O2
4-fluorocatechol + NAD+ + H2O
rate of halophenol consumption 5.3 microM/min/g cell dry weight
-
-
?
4-fluorophenylacetate + NADH + O2
4-fluoro-3-hydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxybenzoate + ?
3,4-dihydroxybenzoate + ?
-
15% of 4-hydroxyphenylacetate activity
-
?
4-hydroxyphenylacetate + FADH2 + O2
3,4-dihydroxyphenylacetate + FAD + H2O
4-hydroxyphenylacetate + FMNH + O2
3,4-dihydroxyphenylacetate + FMN + H2O
4-hydroxyphenylacetate + FMNH2 + O2
3,4-dihydroxyphenylacetate + FMN + H2O
-
-
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
4-hydroxyphenylacetate + NAD(P)H + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
4-hydroxyphenylacetate + NADPH + H+ + O2
3,4-dihydroxyphenylacetate + NADP+ + H2O
4-hydroxyphenylacetic acid + O2 + NADH + H+
3,4-dihydroxyphenylacetic acid + H2O + NAD+
4-hydroxyphenylethanol + O2 + NADH + H+
3,4-dihydroxyphenylethanol + H2O + NAD+
4-iodophenol + NADH + H+ + O2
4-iodocatechol + NAD+ + H2O
rate of halophenol consumption 1.7 microM/min/g cell dry weight
-
-
?
caffeic acid + FADH2 + O2
3,4,5-trihydroxycinnamic acid + FAD + H2O
-
-
-
?
catechol + ?
?
-
30% of 4-hydroxyphenylacetate activity
-
-
?
coniferaldehyde + FADH2 + O2
5-hydroxyconiferaldehyde + FAD + H2O
-
-
-
?
DL-4-hydroxymandelic acid + NADH + H+ + O2
? + NAD+ + H2O
-
-
-
-
?
ferulic acid + FADH2 + O2
5-hydroxyferulic acid + FAD + H2O
-
-
-
?
L-(3,4-dihydroxy)phenylalanine + ?
?
-
10% of 4-hydroxyphenylacetate
-
?
L-tyrosine + ?
L-(3,4-dihydroxy)phenylalanine + ?
-
8% of 4-hydroxyphenylacetate activity
-
?
L-tyrosine + FADH2 + O2
L-(3,4-dihydroxy)phenylalanine + FAD + H2O
methyl 4-hydroxybenzoate + NADH + H+ + O2
? + NAD+ + H2O
-
-
-
-
?
naringenin + FADH2 + O2
? + FAD + H2O
naringin + NADH + H+ + O2
eryodictyol + NADP+ + H2O
octopamine + FMNH + O2
norepinephrine + FMN + H2O
no substrate of wild-type or mutant R263E, R263D, R263A, but substrate of mutant R263D/Y398D
-
-
?
p-coumaric acid + FADH2 + O2
caffeic acid + FAD + H2O
-
-
-
?
p-cresol + ?
?
-
51% of 4-hydroxyphenylacetate activity
-
-
?
phenol + NADH + H+ + O2
? + NAD+ + H2O
-
-
-
-
?
resveratrol + FADH2 + O2
? + FAD + H2O
riboflavin + NADH + H+
reduced riboflavin + NAD+
-
-
-
-
r
tyramine + FMNH + O2
dopamine + FMN + H2O
no substrate of wild-type or mutant R263E, but substrate of mutants R263D and R263A
-
-
?
umbelliferone + FADH2 + O2
? + FAD + H2O
additional information
?
-
3,4-dihydroxyphenylacetate + ?
?
-
65% of 4-hydroxyphenylacetate
-
-
?
3,4-dihydroxyphenylacetate + ?
?
-
50% of 4-hydroxyphenylacetate activity
-
-
?
3-(4-hydroxyphenyl)propionate + ?
3-(3,4-dihydroxy)phenylpropionate + ?
-
-
-
?
3-(4-hydroxyphenyl)propionate + ?
3-(3,4-dihydroxy)phenylpropionate + ?
-
-
-
?
3-(4-hydroxyphenyl)propionate + ?
3-(3,4-dihydroxy)phenylpropionate + ?
-
83% of 4-hydroxyphenylacetate activity
-
?
3-hydroxyphenylacetate + FMNH2 + O2
3,4-hydroxyphenylacetate + FMN + H2O
-
hydroxylation rate constant is 16 per s and the product conversion ratio is 90%
-
?
3-hydroxyphenylacetate + FMNH2 + O2
3,4-hydroxyphenylacetate + FMN + H2O
-
-
-
-
?
3-hydroxyphenylacetate + NAD(P)H + O2
3,4-hydroxyphenylacetate + NAD(P)+ + H2O
-
98% of 4-hydroxyphenylacetate activity
-
-
?
3-hydroxyphenylacetate + NAD(P)H + O2
3,4-hydroxyphenylacetate + NAD(P)+ + H2O
-
-
-
?
3-hydroxyphenylacetate + NAD(P)H + O2
3,4-hydroxyphenylacetate + NAD(P)+ + H2O
-
-
-
?
3-hydroxyphenylacetate + NADH + O2
3,4-hydroxyphenylacetate + NAD+ + H2O
-
82% activity of 4-hydroxyphenylacetate
-
?
3-hydroxyphenylacetate + NADH + O2
3,4-hydroxyphenylacetate + NAD+ + H2O
-
-
-
?
3-hydroxyphenylacetate + NADH + O2
3,4-hydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-aminophenylacetate + ?
4-amino-3-hydroxyphenylacetate + ?
-
-
-
?
4-aminophenylacetate + ?
4-amino-3-hydroxyphenylacetate + ?
-
-
-
?
4-coumaric acid + FADH2 + O2
caffeic acid + FAD + H2O
-
-
-
-
?
4-coumaric acid + FADH2 + O2
caffeic acid + FAD + H2O
-
-
-
?
4-coumaric acid + FADH2 + O2
caffeic acid + FAD + H2O
-
-
-
-
?
4-coumaric acid + FADH2 + O2
caffeic acid + FAD + H2O
-
-
-
?
4-hydroxyphenylacetate + FADH2 + O2
3,4-dihydroxyphenylacetate + FAD + H2O
-
-
-
-
?
4-hydroxyphenylacetate + FADH2 + O2
3,4-dihydroxyphenylacetate + FAD + H2O
-
-
-
-
?
4-hydroxyphenylacetate + FADH2 + O2
3,4-dihydroxyphenylacetate + FAD + H2O
-
-
-
-
?
4-hydroxyphenylacetate + FADH2 + O2
3,4-dihydroxyphenylacetate + FAD + H2O
-
-
-
?
4-hydroxyphenylacetate + FADH2 + O2
3,4-dihydroxyphenylacetate + FAD + H2O
-
4.3 mM 4-hydroxyphenylacetate is converted within 1 h
-
-
?
4-hydroxyphenylacetate + FMNH + O2
3,4-dihydroxyphenylacetate + FMN + H2O
-
-
-
?
4-hydroxyphenylacetate + FMNH + O2
3,4-dihydroxyphenylacetate + FMN + H2O
-
-
-
-
?
4-hydroxyphenylacetate + FMNH + O2
3,4-dihydroxyphenylacetate + FMN + H2O
-
-
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
-
-
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
4-hydroxyphenylacetate, FAD, NADH, and O2 binding structures, overview, the binding and dissociation of flavin are accompanied by conformational changes of the loop between beta5 and beta6 and of the loop between beta8 and beta9, leading to preformation of part of the substrate-binding site involving Ser197 and Thr198. The latter loop further changes its conformation upon binding of 4-hydroxyphenylacetate and obstructs the active site from the bulk solvent. Arg100 is located adjacent to the putative oxygen-binding site and may be involved in the formation and stabilization of the C4a-hydroperoxyflavin intermediate
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
-
FAD and NAD+ are bound in the groove in the extended and folded conformation, respectively, structure, overview
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
4-hydroxyphenylacetate, FAD, NADH, and O2 binding structures, overview, the binding and dissociation of flavin are accompanied by conformational changes of the loop between beta5 and beta6 and of the loop between beta8 and beta9, leading to preformation of part of the substrate-binding site involving Ser197 and Thr198. The latter loop further changes its conformation upon binding of 4-hydroxyphenylacetate and obstructs the active site from the bulk solvent. Arg100 is located adjacent to the putative oxygen-binding site and may be involved in the formation and stabilization of the C4a-hydroperoxyflavin intermediate
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
-
-
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
-
FAD and NAD+ are bound in the groove in the extended and folded conformation, respectively, structure, overview
-
-
?
4-hydroxyphenylacetate + NAD(P)H + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
-
enzyme is induced by 4-hydroxyphenylacetate, no constitutive synthesis
-
ir
4-hydroxyphenylacetate + NAD(P)H + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
-
enzyme is induced by 4-hydroxyphenylacetate, no constitutive synthesis
-
ir
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
HPAH is composed of two proteins: a FMN reductase C1 and an oxygenase C2, C1 catalyzes the reduction of FMN by NADH to generate reduced FMN, FMNH2, for use by C2 in the hydroxylation reaction, C1 is unique among the flavin reductases in that the substrate 4-hydroxyphenylacetate stimulates the rates of both the reduction of FMN and release of FMNH2 from the enzyme, the dissociation of FMNH2 from C1 is rate-limiting in the intermolecular transfer of FMNH2 from C1 to C2, and this process is regulated by the presence of 4-hydroxyphenylacetate , overview
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
substrate binding, catalytic mechanism and structure-function relationship, overview
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
via C2-FMNH-, and C4a-hydroperoxy-FMN and C4a-hydroxy-FMN
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
compared with intracellular cell extracts, the purified recombinant HpaH protein does not display detectable activity toward the 4-hydroxyphenylacetate substrate under the assay conditions used, in contrast to the cell extract, overview
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
compared with intracellular cell extracts, the purified recombinant HpaH protein does not display detectable activity toward the 4-hydroxyphenylacetate substrate under the assay conditions used, in contrast to the cell extract, overview
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
high substrate specificity
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
biodegradation of aromatic compounds
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
high substrate specificity, reduction of enzyme reductase component C1 by NADH occurs in two phases, while in the presence of HPA, the reduction of C1 by NADH occurs in a single phase requiring complex formation of C1 and 4-hydroxyphenylacetate prior to binding of NADH, C1 is specifically reduced by the pro-(S)-hydride, the reaction of reduced C1 with oxygen, the reoxidation reaction is also biphasic, consistent with reduced C1 being a mixture of fast and slow reacting species, rate constants for both phases are the same in the absence and presence of HPA, but in the presence of HPA, the equilibrium shifts toward the faster reacting species
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
hydroxylation occurs from the ternary complex forming the C2-C(4a)-hydroxy-FMN-3,4-dihydroxyphenylacetate complex
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
enzyme is induced by 4-hydroxyphenylacetate, no constitutive synthesis
-
ir
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
enzyme is induced by 4-hydroxyphenylacetate, no constitutive synthesis
-
ir
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of tyrosine with 3,4-dihydroxyphenylacetate as key intermediate
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of tyrosine with 3,4-dihydroxyphenylacetate as key intermediate
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
O2 can be replaced by FADH
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
enzyme is induced by 4-hydroxyphenylacetate, no constitutive synthesis
-
ir
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
initial reaction in the degradation of 4-hydroxyphenylacetate
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
inducible chromosomally encoded meta-cleavage pathway of aromatic degradation
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of 4-hydroxyphenylacetate by inducible meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
4-hydroxyphenylacetic acid degradative pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
first enzyme in 4-hydroxyphenylacetate metabolism
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
enzyme is induced by 4-hydroxyphenylacetate, no constitutive synthesis
-
ir
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of 4-hydroxyphenylacetate by inducible meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
enzyme is induced by 4-hydroxyphenylacetate, no constitutive synthesis
-
ir
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of 4-hydroxyphenylacetate by inducible meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
enzyme is induced by 4-hydroxyphenylacetate, no constitutive synthesis
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
enzyme is induced by 4-hydroxyphenylacetate, no constitutive synthesis
-
ir
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradative pathway involved in the assimilation of different aromatic compounds
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of 4-hydroxyphenylacetate by inducible meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of 4-hydroxyphenylacetate by inducible meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
key enzyme in pathway of degradation of phenylalanine, tyrosine and other aromatic amines
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
enzyme is induced by 4-hydroxyphenylacetate, no constitutive synthesis
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of 4-hydroxyphenylacetate by inducible meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADPH + H+ + O2
3,4-dihydroxyphenylacetate + NADP+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADPH + H+ + O2
3,4-dihydroxyphenylacetate + NADP+ + H2O
-
-
-
?
4-hydroxyphenylacetic acid + O2 + NADH + H+
3,4-dihydroxyphenylacetic acid + H2O + NAD+
-
-
-
-
?
4-hydroxyphenylacetic acid + O2 + NADH + H+
3,4-dihydroxyphenylacetic acid + H2O + NAD+
-
-
-
-
?
4-hydroxyphenylacetic acid + O2 + NADH + H+
3,4-dihydroxyphenylacetic acid + H2O + NAD+
-
-
-
-
?
4-hydroxyphenylethanol + O2 + NADH + H+
3,4-dihydroxyphenylethanol + H2O + NAD+
-
-
-
-
?
4-hydroxyphenylethanol + O2 + NADH + H+
3,4-dihydroxyphenylethanol + H2O + NAD+
-
-
-
-
?
4-hydroxyphenylethanol + O2 + NADH + H+
3,4-dihydroxyphenylethanol + H2O + NAD+
-
-
-
-
?
L-tyrosine + FADH2 + O2
L-(3,4-dihydroxy)phenylalanine + FAD + H2O
1.14.14.9 4-hydroxyphenylacetate 3-monooxygenase
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