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Information on EC 1.14.19.73 - (S)-nandinine synthase

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IUBMB Comments
A cytochrome P-450 heme-thiolate enzyme catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid (S)-nandinine by the oxidative ring closure of adjacent phenolic and methoxy groups of (S)-scoulerine. cf. EC 1.14.21.2, (S)-cheilanthifoline synthase, which catalyses a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-cheilanthifoline.
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The expected taxonomic range for this enzyme is: Eschscholzia californica
Synonyms
(S)-stylopine synthase 2, CYP719A3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-scoulerine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-nandinine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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PATHWAY SOURCE
PATHWAYS
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