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Information on EC 1.14.99.68 - 4-aminobenzoate N-oxygenase

for references in articles please use BRENDA:EC1.14.99.68

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IUBMB Comments

The enzyme, characterized from the bacterium Streptomyces thioluteus, catalyses an early step in the biosynthesis of the antibiotic aureothin. It contains a carboxylate-bridged binuclear non-heme iron cluster. The native electron donor has not been identified, but is likely an iron-sulfur protein. The reaction mechanism involves formation of an extremely stable peroxo intermediate that catalyses three two-electron oxidations via a hydroxylamine and dihydroxylamine intermediates. cf. EC 1.14.99.67, N-[1-(4-aminophenyl)-1,3-dihydroxypropan-2-yl]-2,2-dichloroacetamide N-oxygenase.

The expected taxonomic range for this enzyme is: Streptomyces thioluteus

Synonyms
4-aminobenzoate n-oxygenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-aminobenzoate + reduced acceptor + 2 O2 = 4-nitrobenzoate + acceptor + 2 H2O
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
aureothin biosynthesis, spectinabilin biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links