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Information on EC 1.2.1.10 - acetaldehyde dehydrogenase (acetylating)

for references in articles please use BRENDA:EC1.2.1.10

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IUBMB Comments

Also acts, more slowly, on glycolaldehyde, propanal and butanal. In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87, propanal dehydrogenase (propanoylating). Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols. NADP+ can replace NAD+ but the rate of reaction is much slower .

The enzyme appears in viruses and cellular organisms
Reaction Schemes

Synonyms
dmpfg, coa-dependent aldehyde dehydrogenase, acetyl-coa reductase, tthb247, aldehyde dehydrogenase (acylating), 4-hydroxy-2-ketovalerate aldolase/acylating acetaldehyde dehydrogenase, nonphosphorylating acylating aldehyde dehydrogenase, coenzyme a linked aldehyde dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
2-aminoethylphosphonate degradation I, 2-deoxy-alpha-D-ribose 1-phosphate degradation, 2-deoxy-D-ribose degradation I, 2-hydroxypenta-2,4-dienoate degradation, acetylene degradation (anaerobic), ethanol degradation I, ethanolamine utilization, heterolactic fermentation, L-threonine degradation IV, mixed acid fermentation, pyruvate fermentation to ethanol I, pyruvate fermentation to ethanol III, sulfoacetaldehyde degradation IV, superpathway of fermentation (Chlamydomonas reinhardtii), triethylamine degradation