Information on EC - 2-oxoglutarate dehydrogenase system

for references in articles please use BRENDA:EC1.2.1.105
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IUBMB Comments
The 2-oxoglutarate dehydrogenase system is a large enzyme complex that belongs to the 2-oxoacid dehydrogenase system family, which also includes EC, branched-chain alpha-keto acid dehydrogenase system, EC, pyruvate dehydrogenase system, EC, glycine cleavage system, and EC, acetoin dehydrogenase system. With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a dihydrolipoamide dehydrogenase (E3). This enzyme system converts 2-oxoglutarate to succinyl-CoA and produces NADH and CO2 in a complicated series of irreversible reactions. The reaction catalysed by this system is the sum of three activities: EC, oxoglutarate dehydrogenase (succinyl-transferring) (E1), EC, dihydrolipoyllysine-residue succinyltransferase (E2) and EC, dihydrolipoyl dehydrogenase (E3).
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
2-oxoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase complex, alpha-KDE2, alpha-ketoglutarate dehydrogenase, alpha-ketoglutarate dehydrogenase complex, alpha-KGDH, At3g55410, At5g65750, DHTKD1, dihydrolipoyl succinyltransferase E2, more
2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH
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2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
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