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Reference on EC 1.2.1.24 - succinate-semialdehyde dehydrogenase (NAD+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Friedrich, B.; Magasanik, B.
Enzymes of agmatine degradation and the control of their synthesis in Klebsiella aerogenes
J. Bacteriol.
137
1127-1133
1979
Klebsiella aerogenes
Manually annotated by BRENDA team
Tokunaga, M.; Nakano, Y.; Kitaoka, S.
Separation and properties of the NAD-linked and NADP-linked isozymes of succinic semialdehyde dehydrogenase in Euglena gracilis z
Biochim. Biophys. Acta
429
55-62
1976
Euglena gracilis
Manually annotated by BRENDA team
Choi, S.Y.; Bahn, J.H.; Lee, B.R.; Jeon, S.G.; Jang, J.S.; Kim, C.K.; Jin, L.H.; Kim, K.H.; Park, J.S.; Park, J.; Cho, S.W.
Brain succinic semialdehyde dehydrogenase: identification of reactive lysyl residues labeled with pyridoxal-5'-phosphate
J. Neurochem.
76
919-925
2001
Bos taurus
Manually annotated by BRENDA team
Satya Narayan, V.; Madhusudanan Nair, P.
Potato tuber succinate semialdehyde dehydrogenase: purification and characterization
Arch. Biochem. Biophys.
275
469-477
1989
Solanum tuberosum
Manually annotated by BRENDA team
Yamaura, I.; Matsumoto, T.; Funatsu, M.; Shinohara, T.
Purification and some properties of succinic semialdehyde dehydrogenase from barley seeds
Agric. Biol. Chem.
52
2929-2930
1988
Hordeum vulgare subsp. vulgare
-
Manually annotated by BRENDA team
Ryzlak, M.T.; Pietruszko, R.
Human brain high Km aldehyde dehydrogenase: purification, characterization, and identification as NAD+-dependent succinic semialdehyde dehydrogenase
Arch. Biochem. Biophys.
266
386-396
1988
Homo sapiens
Manually annotated by BRENDA team
Ferrer, E.; Cooper, R.A.
a single succinic semialdehyde dehydrogenase is involved in 4-hydroxyphenylacetate and 4-aminobutyrate catabolism in Klebsiella pneumoniae M5a1
FEMS Microbiol. Lett.
52
161-164
1988
Klebsiella pneumoniae, Klebsiella pneumoniae M5a1
-
Manually annotated by BRENDA team
Marek, L.E.; Henson, J.M.
Cloning and expression of the Escherichia coli K-12 sad gene
J. Bacteriol.
170
991-994
1988
Escherichia coli
Manually annotated by BRENDA team
Sims, G.K.; Sommers, L.E.; Konopka, A.
Degradation of pyridine by Micrococcus luteus isolated from soil
Appl. Environ. Microbiol.
51
963-968
1986
Micrococcus luteus
Manually annotated by BRENDA team
Hearl, W.G.; Churchich, J.E.
Interactions between 4-aminobutyrate aminotransferase and succinic semialdehyde dehydrogenase, two mitochondrial enzymes
J. Biol. Chem.
259
11459-11463
1984
Sus scrofa
Manually annotated by BRENDA team
Galleschi, L.; Nocchi, C.; Floris, C.; Bedini, G.; Anguillesi, M.C.; Grilli, I.
Succinic semialdehyde dehydrogenase in higher plants: purification and properties of the enzyme from Triticum durum embryos
Biochem. Physiol. Pflanz.
178
645-651
1983
Triticum turgidum subsp. durum
-
Manually annotated by BRENDA team
Rivett, A.J.; Tipton, K.F.
Kinetic studies with rat-brain succinic-semialdehyde dehydrogenase
Eur. J. Biochem.
117
187-193
1981
Rattus norvegicus
Manually annotated by BRENDA team
Donnelly, M.I.; Cooper, R.A.
Two succinic semialdehyde dehydrogenases are induced when Escherichia coli K-12 is grown on gamma-aminobutyrate
J. Bacteriol.
145
1425-1427
1981
Escherichia coli
Manually annotated by BRENDA team
Blaner, W.S.; Churchich, J.E.
The binding of NADH to succinic semialdehyde dehydrogenase
Eur. J. Biochem.
109
431-437
1980
Sus scrofa
Manually annotated by BRENDA team
Lai, J.C.K.; Clark, J.B.
Preparation of synaptic and nonsynaptic mitochondria from mammalian brain
Methods Enzymol.
55
51-60
1979
Rattus norvegicus
Manually annotated by BRENDA team
Blaner, W.S.; Churchich, J.
Succinic semialdehyde dehydrogenase. Reactivity of lysyl residues
J. Biol. Chem.
254
1794-1798
1979
Sus scrofa
Manually annotated by BRENDA team
Galleschi, L.; Tozzi, M.G.; Cozzani, I.; Floris, C.
Succinic semialdehyde dehydrogenase of wheat grain
Planta
142
175-180
1978
Triticum turgidum subsp. durum
Manually annotated by BRENDA team
Cash, C.D.; Maitre, M.; Ossola, L.; Mandel, P.
Purification and properties of two succinate semialdehyde dehydrogenases from human brain
Biochim. Biophys. Acta
524
26-36
1978
Homo sapiens
Manually annotated by BRENDA team
Cash, C.; Ciesielski, L.; Maitre, M.; Mandel, P.
Purification and properties of rat brain succinic semialdehyde dehydrogenase
Biochimie
59
257-268
1977
Rattus norvegicus
Manually annotated by BRENDA team
Callewaert, D.M.; Rosemblatt, M.S.; Suzuki, K.; Tchen, T.T.
Succinic semialdehyde dehydrogenase from a Pseudomonas species. I. Purification and chemical properties
J. Biol. Chem.
248
6009-6013
1973
Pseudomonas sp.
Manually annotated by BRENDA team
Rosemblatt, M.S.; Callewaert, D.M.; Tchen, T.T.
Succinic semialdehyde dehydrogenase from a Pseudomonas species. II. Physical and immunochemical properties of the enzyme
J. Biol. Chem.
248
6014-6018
1973
Pseudomonas sp.
Manually annotated by BRENDA team
Kumar, S.; Punekar, N.S.
Inhibition of succinic semialdehyde dehydrogenase by N-formylglycine
J. Enzyme Inhib.
13
369-376
1998
Aspergillus niger, Solanum tuberosum
Manually annotated by BRENDA team
Albers, R.W.; Koval, G.J.
Succinic semialdehyde dehydrogenase: purification and properties of the enzyme from monkey brain
Biochim. Biophys. Acta
52
29-35
1961
Platyrrhini
Manually annotated by BRENDA team
Koh, Y.S.; Joo, C.N.; Choi, S.Y.; Kim, D.S.
Purification and properties of succinic semialdehyde dehydrogenase from Lumbricus rubellus
Korean Biochem. J.
27
75-79
1994
Lumbricus rubellus
-
Manually annotated by BRENDA team
Chambliss, K.L.; Caudle, D.L.; Hinson, D.D.; Moomaw, C.R.; Slaughter, C.A.; Jakobs, C.; Gibson, K.M.
Molecular cloning of the mature NAD(+)-dependent succinic semialdehyde dehydrogenase from rat and human. cDNA isolation, evolutionary homology, and tissue expression
J. Biol. Chem.
270
461-467
1995
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Busch, K.B.; Fromm, H.
Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides
Plant Physiol.
121
589-597
1999
Arabidopsis sp.
Manually annotated by BRENDA team
Chambliss, K.L.; Zhang, Y.A.; Rossier, E.; Vollmer, B.; Gibson, K.M.
Enzymatic and immunologic identification of succinic semialdehyde dehydrogenase in rat and human neural and nonneural tissues
J. Neurochem.
65
851-855
1995
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Nguyen, E.; Picklo, M.J., Sr.
Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation
Biochim. Biophys. Acta
1637
107-112
2003
Rattus norvegicus
Manually annotated by BRENDA team
Lee, B.R.; Kim, D.W.; Hong, J.W.; Eum, W.S.; Choi, H.S.; Choi, S.H.; Kim, S.Y.; An, J.J.; Ahn, J.Y.; Kwon, O.S.; Kang, T.C.; Won, M.H.; Cho, S.W.; Lee, K.S.; Park, J.; Choi, S.Y.
Brain succinic semialdehyde dehydrogenase. Reactions of sulfhydryl residues connected with catalytic activity
Eur. J. Biochem.
271
4903-4908
2004
Bos taurus
Manually annotated by BRENDA team
Akaboshi, S.; Hogema, B.M.; Novelletto, A.; Malaspina, P.; Salomons, G.S.; Maropoulos, G.D.; Jakobs, C.; Grompe, M.; Gibson, K.M.
Mutational spectrum of the succinate semialdehyde dehydrogenase (ALDH5A1) gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency
Hum. Mutat.
22
442-450
2003
Homo sapiens (P51649)
Manually annotated by BRENDA team
Murphy, T.C.; Amarnath, V.; Gibson, K.M.; Picklo, M.J., Sr.
Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A)
J. Neurochem.
86
298-305
2003
Rattus norvegicus
Manually annotated by BRENDA team
Blasi, P.; Boyl, P.P.; Ledda, M.; Novelletto, A.; Gibson, K.M.; Jakobs, C.; Hogema, B.; Akaboshi, S.; Loreni, F.; Malaspina, P.
Structure of human succinic semialdehyde dehydrogenase gene: identification of promoter region and alternatively processed isoforms
Mol. Genet. Metab.
76
348-362
2002
Homo sapiens (Q8N3W7), Homo sapiens
Manually annotated by BRENDA team
Bouche, N.; Fait, A.; Bouchez, D.; Moller, S.G.; Fromm, H.
Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants
Proc. Natl. Acad. Sci. USA
100
6843-6848
2003
Arabidopsis sp.
Manually annotated by BRENDA team
Watanabe, S.; Kodaki, T.; Makino, K.
A novel alpha-ketoglutaric semialdehyde dehydrogenase: evolutionary insight into an alternative pathway of bacterial L-arabinose metabolism
J. Biol. Chem.
281
28876-28888
2006
Azospirillum brasilense (Q1JUP4), Azospirillum brasilense
Manually annotated by BRENDA team
Blasi, P.; Palmerio, F.; Aiello, A.; Rocchi, M.; Malaspina, P.; Novelletto, A.
SSADH variation in primates: intra- and interspecific data on a gene with a potential role in human cognitive functions
J. Mol. Evol.
63
54-68
2006
Homo sapiens, Hylobates lar (Q3MSM3), Pan paniscus (Q3MSM4), Pan paniscus, Pan troglodytes (Q6A2H0), Pan troglodytes, Gorilla gorilla (Q6A2H1), Pongo pygmaeus pygmaeus (Q6A2H2), Pongo abelii (Q6A2H2)
Manually annotated by BRENDA team
Lorenz, S.; Heils, A.; Taylor, K.P.; Gehrmann, A.; Muhle, H.; Gresch, M.; Becker, T.; Tauer, U.; Stephani, U.; Sander, T.
Candidate gene analysis of the succinic semialdehyde dehydrogenase gene (ALDH5A1) in patients with idiopathic generalized epilepsy and photosensitivity
Neurosci. Lett.
397
234-239
2006
Homo sapiens
Manually annotated by BRENDA team
Kang, J.H.; Park, Y.B.; Huh, T.L.; Lee, W.H.; Choi, M.S.; Kwon, O.S.
High-level expression and characterization of the recombinant enzyme, and tissue distribution of human succinic semialdehyde dehydrogenase
Protein Expr. Purif.
44
16-22
2005
Homo sapiens
Manually annotated by BRENDA team
Marchitti, S.A.; Deitrich, R.A.; Vasiliou, V.
Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase
Pharmacol. Rev.
59
125-150
2007
Homo sapiens (P51649)
Manually annotated by BRENDA team
Leone, O.; Blasi, P.; Palmerio, F.; Kozlov, A.I.; Malaspina, P.; Novelletto, A.
A human derived SSADH coding variant is replacing the ancestral allele shared with primates
Ann. Hum. Biol.
33
593-603
2007
Homo sapiens (P51649), Homo sapiens
Manually annotated by BRENDA team
Rothacker, B.; Ilg, T.
Functional characterization of a Drosophila melanogaster succinic semialdehyde dehydrogenase and a non-specific aldehyde dehydrogenase
Insect Biochem. Mol. Biol.
38
354-366
2008
Drosophila melanogaster (Q9VBP6)
Manually annotated by BRENDA team
Rothacker, B.; Werr, M.; Ilg, T.
Molecular cloning, partial genomic structure and functional characterization of succinic semialdehyde dehydrogenase genes from the parasitic insects Lucilia cuprina and Ctenocephalides felis
Insect Mol. Biol.
17
279-291
2008
Ctenocephalides felis, Lucilia cuprina (B0JFD4)
Manually annotated by BRENDA team
Fuhrer, T.; Chen, L.; Sauer, U.; Vitkup, D.
Computational prediction and experimental verification of the gene encoding the NAD+/NADP+-dependent succinate semialdehyde dehydrogenase in Escherichia coli
J. Bacteriol.
189
8073-8078
2007
Escherichia coli, Escherichia coli BW25113
Manually annotated by BRENDA team
Sauer, S.W.; Koelker, S.; Hoffmann, G.F.; Ten Brink, H.J.; Jakobs, C.; Gibson, K.M.; Okun, J.G.
Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency (Aldh5a1-/- mice)
Neurochem. Int.
50
653-659
2007
Mus musculus (Q8BWF0)
Manually annotated by BRENDA team
Jansen, E.E.; Struys, E.; Jakobs, C.; Hager, E.; Snead, O.C.; Gibson, K.M.
Neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase (SSADH) deficiency suggest a heightened excitatory state during development
BMC Dev. Biol.
8
112
2008
Mus musculus
Manually annotated by BRENDA team
Swenby, N.P.; Picklo, M.J.
The conserved R166 residue of ALDH5A (succinic semialdehyde dehydrogenase) has multiple functional roles
Chem. Biol. Interact.
178
70-74
2009
Rattus norvegicus
Manually annotated by BRENDA team
Knerr, I.; Gibson, K.M.; Jakobs, C.; Pearl, P.L.
Neuropsychiatric morbidity in adolescent and adult succinic semialdehyde dehydrogenase deficiency patients
CNS Spectr.
13
598-605
2008
Homo sapiens
Manually annotated by BRENDA team
Stewart, L.S.; Nylen, K.J.; Persinger, M.A.; Cortez, M.A.; Gibson, K.M.; Snead, O.C.
Circadian distribution of generalized tonic-clonic seizures associated with murine succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism
Epilepsy Behav.
13
290-294
2008
Mus musculus
Manually annotated by BRENDA team
Nylen, K.; Velazquez, J.L.; Likhodii, S.S.; Cortez, M.A.; Shen, L.; Leshchenko, Y.; Adeli, K.; Gibson, K.M.; Burnham, W.M.; Snead, O.C.
A ketogenic diet rescues the murine succinic semialdehyde dehydrogenase deficient phenotype
Exp. Neurol.
210
449-457
2008
Mus musculus
Manually annotated by BRENDA team
Malaspina, P.; Picklo, M.J.; Jakobs, C.; Snead, O.C.; Gibson, K.M.
Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency
Hum. Genomics
3
106-120
2009
Homo sapiens
Manually annotated by BRENDA team
Pearl, P.L.; Gibson, K.M.; Cortez, M.A.; Wu, Y.; Carter Snead, O.; Knerr, I.; Forester, K.; Pettiford, J.M.; Jakobs, C.; Theodore, W.H.
Succinic semialdehyde dehydrogenase deficiency: lessons from mice and men
J. Inherit. Metab. Dis.
32
343-352
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Kratz, S.V.
Sensory integration intervention: historical concepts, treatment strategies and clinical experiences in three patients with succinic semialdehyde dehydrogenase (SSADH) deficiency
J. Inherit. Metab. Dis.
32
353-360
2009
Homo sapiens
Manually annotated by BRENDA team
Di Rosa, G.; Malaspina, P.; Blasi, P.; Dionisi-Vici, C.; Rizzo, C.; Tortorella, G.; Crutchfield, S.R.; Gibson, K.M.
Visual evoked potentials in succinate semialdehyde dehydrogenase (SSADH) deficiency
J. Inherit. Metab. Dis.
32
S201-S205
2009
Homo sapiens
Manually annotated by BRENDA team
Rothacker, B.; Werr, M.; Ilg, T.
Succinic semialdehyde dehydrogenase from the parasitic cattle tick Rhipicephalus microplus: gene identification, biochemical characterization and comparison with the mouse ortholog
Mol. Biochem. Parasitol.
161
32-43
2008
Rhipicephalus microplus, Mus musculus (Q8BWF0)
Manually annotated by BRENDA team
Pearl, P.L.; Gibson, K.M.; Quezado, Z.; Dustin, I.; Taylor, J.; Trzcinski, S.; Schreiber, J.; Forester, K.; Reeves-Tyer, P.; Liew, C.; Shamim, S.; Herscovitch, P.; Carson, R.; Butman, J.; Jakobs, C.; Theodore, W.
Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency
Neurology
73
423-429
2009
Homo sapiens
Manually annotated by BRENDA team
Ludewig, F.; Hueser, A.; Fromm, H.; Beauclair, L.; Bouche, N.
Mutants of GABA transaminase (POP2) suppress the severe phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis
PLoS ONE
3
e3383
2008
Arabidopsis thaliana (Q9SAK4)
Manually annotated by BRENDA team
Cozzani, I.; Fazio, A.M.; Felici, E.; Barletta, G.
Separation and characterization of NAD- and NADP-specific succinate-semialdehyde dehydrogenase from Escherichia coli K-12 3300
Biochim. Biophys. Acta
613
309-317
1980
Escherichia coli K-12
Manually annotated by BRENDA team
Langendorf, C.G.; Key, T.L.; Fenalti, G.; Kan, W.T.; Buckle, A.M.; Caradoc-Davies, T.; Tuck, K.L.; Law, R.H.; Whisstock, J.C.
The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions
PLoS One
5
e9280
2010
Homo sapiens (P51649)
Manually annotated by BRENDA team
Kim, K.J.; Pearl, P.; Jensen, K.; Snead, O.C.; Malaspina, P.; Jakobs, C.; Gibson, K.M.
Succinic semialdehyde dehydrogenase (SSADH): biochemical-molecular-clinical disease mechanisms, redox regulation and functional significance
Antioxid. Redox Signal.
15
691-718
2011
Mus musculus, Homo sapiens (P51649), Homo sapiens
Manually annotated by BRENDA team
Esser, D.; Kouril, T.; Talfournier, F.; Polkowska, J.; Schrader, T.; Brsen, C.; Siebers, B.
Unraveling the function of paralogs of the aldehyde dehydrogenase super family from Sulfolobus solfataricus
Extremophiles
17
205-216
2013
Saccharolobus solfataricus (Q97XS9), Saccharolobus solfataricus
Manually annotated by BRENDA team
Puettmann, L.; Stehr, H.; Garshasbi, M.; Hu, H.; Kahrizi, K.; Lipkowitz, B.; Jamali, P.; Tzschach, A.; Najmabadi, H.; Ropers, H.H.; Musante, L.; Kuss, A.W.
A novel ALDH5A1 mutation is associated with succinic semialdehyde dehydrogenase deficiency and severe intellectual disability in an Iranian family
Am. J. Med. Genet. A
161A
1915-1922
2013
Homo sapiens (P51649), Homo sapiens
Manually annotated by BRENDA team
Kumar, S.; Kumar, S.; Punekar, N.S.
Characterization of succinic semialdehyde dehydrogenase from Aspergillus niger
Indian J. Exp. Biol.
53
67-74
2015
Aspergillus niger (A2R4V5), Aspergillus niger NCIM 565 (A2R4V5)
Manually annotated by BRENDA team
Tamazian, G.; Ho Chang, J.; Knyazev, S.; Stepanov, E.; Kim, K.J.; Porozov, Y.
Modeling conformational redox-switch modulation of human succinic semialdehyde dehydrogenase
Proteins
83
2217-2229
2015
Homo sapiens (P51649)
Manually annotated by BRENDA team
Hujber, Z.; Horvath, G.; Petoevari, G.; Krencz, I.; Danko, T.; Meszaros, K.; Rajnai, H.; Szoboszlai, N.; Leenders, W.P.J.; Jeney, A.; Tretter, L.; Sebestyen, A.
GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas
J. Exp. Clin. Cancer Res.
37
271
2018
Homo sapiens (P51649)
Manually annotated by BRENDA team
Brown, M.N.; Walters, D.C.; Schmidt, M.A.; Hill, J.; McConnell, A.; Jansen, E.E.W.; Salomons, G.S.; Arning, E.; Bottiglieri, T.; Gibson, K.M.; Roullet, J.B.
Maternal glutamine supplementation in murine succinic semialdehyde dehydrogenase deficiency, a disorder of gamma-aminobutyric acid metabolism
J. Inherit. Metab. Dis.
42
1030-1039
2019
Mus musculus (Q8BWF0), Mus musculus C57BL/6 (Q8BWF0)
Manually annotated by BRENDA team
Menduti, G.; Biamino, E.; Vittorini, R.; Vesco, S.; Puccinelli, M.P.; Porta, F.; Capo, C.; Leo, S.; Ciminelli, B.M.; Iacovelli, F.; Spada, M.; Falconi, M.; Malaspina, P.; Rossi, L.
Succinic semialdehyde dehydrogenase deficiency The combination of a novel ALDH5A1 gene mutation and a missense SNP strongly affects SSADH enzyme activity and stability
Mol. Genet. Metab.
124
210-215
2018
Homo sapiens (P51649)
Manually annotated by BRENDA team