Reference on EC 1.2.1.24 - succinate-semialdehyde dehydrogenase (NAD+)
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Friedrich, B.; Magasanik, B.
Enzymes of agmatine degradation and the control of their synthesis in Klebsiella aerogenes
J. Bacteriol.
137
1127-1133
1979
Klebsiella aerogenes
Tokunaga, M.; Nakano, Y.; Kitaoka, S.
Separation and properties of the NAD-linked and NADP-linked isozymes of succinic semialdehyde dehydrogenase in Euglena gracilis z
Biochim. Biophys. Acta
429
55-62
1976
Euglena gracilis
Choi, S.Y.; Bahn, J.H.; Lee, B.R.; Jeon, S.G.; Jang, J.S.; Kim, C.K.; Jin, L.H.; Kim, K.H.; Park, J.S.; Park, J.; Cho, S.W.
Brain succinic semialdehyde dehydrogenase: identification of reactive lysyl residues labeled with pyridoxal-5'-phosphate
J. Neurochem.
76
919-925
2001
Bos taurus
Satya Narayan, V.; Madhusudanan Nair, P.
Potato tuber succinate semialdehyde dehydrogenase: purification and characterization
Arch. Biochem. Biophys.
275
469-477
1989
Solanum tuberosum
Yamaura, I.; Matsumoto, T.; Funatsu, M.; Shinohara, T.
Purification and some properties of succinic semialdehyde dehydrogenase from barley seeds
Agric. Biol. Chem.
52
2929-2930
1988
Hordeum vulgare subsp. vulgare
-
Ryzlak, M.T.; Pietruszko, R.
Human brain high Km aldehyde dehydrogenase: purification, characterization, and identification as NAD+-dependent succinic semialdehyde dehydrogenase
Arch. Biochem. Biophys.
266
386-396
1988
Homo sapiens
Ferrer, E.; Cooper, R.A.
a single succinic semialdehyde dehydrogenase is involved in 4-hydroxyphenylacetate and 4-aminobutyrate catabolism in Klebsiella pneumoniae M5a1
FEMS Microbiol. Lett.
52
161-164
1988
Klebsiella pneumoniae, Klebsiella pneumoniae M5a1
-
Marek, L.E.; Henson, J.M.
Cloning and expression of the Escherichia coli K-12 sad gene
J. Bacteriol.
170
991-994
1988
Escherichia coli
Sims, G.K.; Sommers, L.E.; Konopka, A.
Degradation of pyridine by Micrococcus luteus isolated from soil
Appl. Environ. Microbiol.
51
963-968
1986
Micrococcus luteus
Hearl, W.G.; Churchich, J.E.
Interactions between 4-aminobutyrate aminotransferase and succinic semialdehyde dehydrogenase, two mitochondrial enzymes
J. Biol. Chem.
259
11459-11463
1984
Sus scrofa
Galleschi, L.; Nocchi, C.; Floris, C.; Bedini, G.; Anguillesi, M.C.; Grilli, I.
Succinic semialdehyde dehydrogenase in higher plants: purification and properties of the enzyme from Triticum durum embryos
Biochem. Physiol. Pflanz.
178
645-651
1983
Triticum turgidum subsp. durum
-
Rivett, A.J.; Tipton, K.F.
Kinetic studies with rat-brain succinic-semialdehyde dehydrogenase
Eur. J. Biochem.
117
187-193
1981
Rattus norvegicus
Donnelly, M.I.; Cooper, R.A.
Two succinic semialdehyde dehydrogenases are induced when Escherichia coli K-12 is grown on gamma-aminobutyrate
J. Bacteriol.
145
1425-1427
1981
Escherichia coli
Blaner, W.S.; Churchich, J.E.
The binding of NADH to succinic semialdehyde dehydrogenase
Eur. J. Biochem.
109
431-437
1980
Sus scrofa
Lai, J.C.K.; Clark, J.B.
Preparation of synaptic and nonsynaptic mitochondria from mammalian brain
Methods Enzymol.
55
51-60
1979
Rattus norvegicus
Blaner, W.S.; Churchich, J.
Succinic semialdehyde dehydrogenase. Reactivity of lysyl residues
J. Biol. Chem.
254
1794-1798
1979
Sus scrofa
Galleschi, L.; Tozzi, M.G.; Cozzani, I.; Floris, C.
Succinic semialdehyde dehydrogenase of wheat grain
Planta
142
175-180
1978
Triticum turgidum subsp. durum
Cash, C.D.; Maitre, M.; Ossola, L.; Mandel, P.
Purification and properties of two succinate semialdehyde dehydrogenases from human brain
Biochim. Biophys. Acta
524
26-36
1978
Homo sapiens
Cash, C.; Ciesielski, L.; Maitre, M.; Mandel, P.
Purification and properties of rat brain succinic semialdehyde dehydrogenase
Biochimie
59
257-268
1977
Rattus norvegicus
Callewaert, D.M.; Rosemblatt, M.S.; Suzuki, K.; Tchen, T.T.
Succinic semialdehyde dehydrogenase from a Pseudomonas species. I. Purification and chemical properties
J. Biol. Chem.
248
6009-6013
1973
Pseudomonas sp.
Rosemblatt, M.S.; Callewaert, D.M.; Tchen, T.T.
Succinic semialdehyde dehydrogenase from a Pseudomonas species. II. Physical and immunochemical properties of the enzyme
J. Biol. Chem.
248
6014-6018
1973
Pseudomonas sp.
Kumar, S.; Punekar, N.S.
Inhibition of succinic semialdehyde dehydrogenase by N-formylglycine
J. Enzyme Inhib.
13
369-376
1998
Aspergillus niger, Solanum tuberosum
Albers, R.W.; Koval, G.J.
Succinic semialdehyde dehydrogenase: purification and properties of the enzyme from monkey brain
Biochim. Biophys. Acta
52
29-35
1961
Platyrrhini
Koh, Y.S.; Joo, C.N.; Choi, S.Y.; Kim, D.S.
Purification and properties of succinic semialdehyde dehydrogenase from Lumbricus rubellus
Korean Biochem. J.
27
75-79
1994
Lumbricus rubellus
-
Chambliss, K.L.; Caudle, D.L.; Hinson, D.D.; Moomaw, C.R.; Slaughter, C.A.; Jakobs, C.; Gibson, K.M.
Molecular cloning of the mature NAD(+)-dependent succinic semialdehyde dehydrogenase from rat and human. cDNA isolation, evolutionary homology, and tissue expression
J. Biol. Chem.
270
461-467
1995
Homo sapiens, Rattus norvegicus
Busch, K.B.; Fromm, H.
Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides
Plant Physiol.
121
589-597
1999
Arabidopsis sp.
Chambliss, K.L.; Zhang, Y.A.; Rossier, E.; Vollmer, B.; Gibson, K.M.
Enzymatic and immunologic identification of succinic semialdehyde dehydrogenase in rat and human neural and nonneural tissues
J. Neurochem.
65
851-855
1995
Homo sapiens, Rattus norvegicus
Nguyen, E.; Picklo, M.J., Sr.
Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation
Biochim. Biophys. Acta
1637
107-112
2003
Rattus norvegicus
Lee, B.R.; Kim, D.W.; Hong, J.W.; Eum, W.S.; Choi, H.S.; Choi, S.H.; Kim, S.Y.; An, J.J.; Ahn, J.Y.; Kwon, O.S.; Kang, T.C.; Won, M.H.; Cho, S.W.; Lee, K.S.; Park, J.; Choi, S.Y.
Brain succinic semialdehyde dehydrogenase. Reactions of sulfhydryl residues connected with catalytic activity
Eur. J. Biochem.
271
4903-4908
2004
Bos taurus
Akaboshi, S.; Hogema, B.M.; Novelletto, A.; Malaspina, P.; Salomons, G.S.; Maropoulos, G.D.; Jakobs, C.; Grompe, M.; Gibson, K.M.
Mutational spectrum of the succinate semialdehyde dehydrogenase (ALDH5A1) gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency
Hum. Mutat.
22
442-450
2003
Homo sapiens (P51649)
Murphy, T.C.; Amarnath, V.; Gibson, K.M.; Picklo, M.J., Sr.
Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A)
J. Neurochem.
86
298-305
2003
Rattus norvegicus
Blasi, P.; Boyl, P.P.; Ledda, M.; Novelletto, A.; Gibson, K.M.; Jakobs, C.; Hogema, B.; Akaboshi, S.; Loreni, F.; Malaspina, P.
Structure of human succinic semialdehyde dehydrogenase gene: identification of promoter region and alternatively processed isoforms
Mol. Genet. Metab.
76
348-362
2002
Homo sapiens (Q8N3W7), Homo sapiens
Bouche, N.; Fait, A.; Bouchez, D.; Moller, S.G.; Fromm, H.
Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants
Proc. Natl. Acad. Sci. USA
100
6843-6848
2003
Arabidopsis sp.
Watanabe, S.; Kodaki, T.; Makino, K.
A novel alpha-ketoglutaric semialdehyde dehydrogenase: evolutionary insight into an alternative pathway of bacterial L-arabinose metabolism
J. Biol. Chem.
281
28876-28888
2006
Azospirillum brasilense (Q1JUP4), Azospirillum brasilense
Blasi, P.; Palmerio, F.; Aiello, A.; Rocchi, M.; Malaspina, P.; Novelletto, A.
SSADH variation in primates: intra- and interspecific data on a gene with a potential role in human cognitive functions
J. Mol. Evol.
63
54-68
2006
Homo sapiens, Hylobates lar (Q3MSM3), Pan paniscus (Q3MSM4), Pan paniscus, Pan troglodytes (Q6A2H0), Pan troglodytes, Gorilla gorilla (Q6A2H1), Pongo pygmaeus pygmaeus (Q6A2H2), Pongo abelii (Q6A2H2)
Lorenz, S.; Heils, A.; Taylor, K.P.; Gehrmann, A.; Muhle, H.; Gresch, M.; Becker, T.; Tauer, U.; Stephani, U.; Sander, T.
Candidate gene analysis of the succinic semialdehyde dehydrogenase gene (ALDH5A1) in patients with idiopathic generalized epilepsy and photosensitivity
Neurosci. Lett.
397
234-239
2006
Homo sapiens
Kang, J.H.; Park, Y.B.; Huh, T.L.; Lee, W.H.; Choi, M.S.; Kwon, O.S.
High-level expression and characterization of the recombinant enzyme, and tissue distribution of human succinic semialdehyde dehydrogenase
Protein Expr. Purif.
44
16-22
2005
Homo sapiens
Marchitti, S.A.; Deitrich, R.A.; Vasiliou, V.
Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase
Pharmacol. Rev.
59
125-150
2007
Homo sapiens (P51649)
Leone, O.; Blasi, P.; Palmerio, F.; Kozlov, A.I.; Malaspina, P.; Novelletto, A.
A human derived SSADH coding variant is replacing the ancestral allele shared with primates
Ann. Hum. Biol.
33
593-603
2007
Homo sapiens (P51649), Homo sapiens
Rothacker, B.; Ilg, T.
Functional characterization of a Drosophila melanogaster succinic semialdehyde dehydrogenase and a non-specific aldehyde dehydrogenase
Insect Biochem. Mol. Biol.
38
354-366
2008
Drosophila melanogaster (Q9VBP6)
Rothacker, B.; Werr, M.; Ilg, T.
Molecular cloning, partial genomic structure and functional characterization of succinic semialdehyde dehydrogenase genes from the parasitic insects Lucilia cuprina and Ctenocephalides felis
Insect Mol. Biol.
17
279-291
2008
Ctenocephalides felis, Lucilia cuprina (B0JFD4)
Fuhrer, T.; Chen, L.; Sauer, U.; Vitkup, D.
Computational prediction and experimental verification of the gene encoding the NAD+/NADP+-dependent succinate semialdehyde dehydrogenase in Escherichia coli
J. Bacteriol.
189
8073-8078
2007
Escherichia coli, Escherichia coli BW25113
Sauer, S.W.; Koelker, S.; Hoffmann, G.F.; Ten Brink, H.J.; Jakobs, C.; Gibson, K.M.; Okun, J.G.
Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency (Aldh5a1-/- mice)
Neurochem. Int.
50
653-659
2007
Mus musculus (Q8BWF0)
Jansen, E.E.; Struys, E.; Jakobs, C.; Hager, E.; Snead, O.C.; Gibson, K.M.
Neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase (SSADH) deficiency suggest a heightened excitatory state during development
BMC Dev. Biol.
8
112
2008
Mus musculus
Swenby, N.P.; Picklo, M.J.
The conserved R166 residue of ALDH5A (succinic semialdehyde dehydrogenase) has multiple functional roles
Chem. Biol. Interact.
178
70-74
2009
Rattus norvegicus
Knerr, I.; Gibson, K.M.; Jakobs, C.; Pearl, P.L.
Neuropsychiatric morbidity in adolescent and adult succinic semialdehyde dehydrogenase deficiency patients
CNS Spectr.
13
598-605
2008
Homo sapiens
Stewart, L.S.; Nylen, K.J.; Persinger, M.A.; Cortez, M.A.; Gibson, K.M.; Snead, O.C.
Circadian distribution of generalized tonic-clonic seizures associated with murine succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism
Epilepsy Behav.
13
290-294
2008
Mus musculus
Nylen, K.; Velazquez, J.L.; Likhodii, S.S.; Cortez, M.A.; Shen, L.; Leshchenko, Y.; Adeli, K.; Gibson, K.M.; Burnham, W.M.; Snead, O.C.
A ketogenic diet rescues the murine succinic semialdehyde dehydrogenase deficient phenotype
Exp. Neurol.
210
449-457
2008
Mus musculus
Malaspina, P.; Picklo, M.J.; Jakobs, C.; Snead, O.C.; Gibson, K.M.
Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency
Hum. Genomics
3
106-120
2009
Homo sapiens
Pearl, P.L.; Gibson, K.M.; Cortez, M.A.; Wu, Y.; Carter Snead, O.; Knerr, I.; Forester, K.; Pettiford, J.M.; Jakobs, C.; Theodore, W.H.
Succinic semialdehyde dehydrogenase deficiency: lessons from mice and men
J. Inherit. Metab. Dis.
32
343-352
2009
Homo sapiens, Mus musculus
Kratz, S.V.
Sensory integration intervention: historical concepts, treatment strategies and clinical experiences in three patients with succinic semialdehyde dehydrogenase (SSADH) deficiency
J. Inherit. Metab. Dis.
32
353-360
2009
Homo sapiens
Di Rosa, G.; Malaspina, P.; Blasi, P.; Dionisi-Vici, C.; Rizzo, C.; Tortorella, G.; Crutchfield, S.R.; Gibson, K.M.
Visual evoked potentials in succinate semialdehyde dehydrogenase (SSADH) deficiency
J. Inherit. Metab. Dis.
32
S201-S205
2009
Homo sapiens
Rothacker, B.; Werr, M.; Ilg, T.
Succinic semialdehyde dehydrogenase from the parasitic cattle tick Rhipicephalus microplus: gene identification, biochemical characterization and comparison with the mouse ortholog
Mol. Biochem. Parasitol.
161
32-43
2008
Rhipicephalus microplus, Mus musculus (Q8BWF0)
Pearl, P.L.; Gibson, K.M.; Quezado, Z.; Dustin, I.; Taylor, J.; Trzcinski, S.; Schreiber, J.; Forester, K.; Reeves-Tyer, P.; Liew, C.; Shamim, S.; Herscovitch, P.; Carson, R.; Butman, J.; Jakobs, C.; Theodore, W.
Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency
Neurology
73
423-429
2009
Homo sapiens
Ludewig, F.; Hueser, A.; Fromm, H.; Beauclair, L.; Bouche, N.
Mutants of GABA transaminase (POP2) suppress the severe phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis
PLoS ONE
3
e3383
2008
Arabidopsis thaliana (Q9SAK4)
Cozzani, I.; Fazio, A.M.; Felici, E.; Barletta, G.
Separation and characterization of NAD- and NADP-specific succinate-semialdehyde dehydrogenase from Escherichia coli K-12 3300
Biochim. Biophys. Acta
613
309-317
1980
Escherichia coli K-12
Langendorf, C.G.; Key, T.L.; Fenalti, G.; Kan, W.T.; Buckle, A.M.; Caradoc-Davies, T.; Tuck, K.L.; Law, R.H.; Whisstock, J.C.
The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions
PLoS One
5
e9280
2010
Homo sapiens (P51649)
Kim, K.J.; Pearl, P.; Jensen, K.; Snead, O.C.; Malaspina, P.; Jakobs, C.; Gibson, K.M.
Succinic semialdehyde dehydrogenase (SSADH): biochemical-molecular-clinical disease mechanisms, redox regulation and functional significance
Antioxid. Redox Signal.
15
691-718
2011
Mus musculus, Homo sapiens (P51649), Homo sapiens
Esser, D.; Kouril, T.; Talfournier, F.; Polkowska, J.; Schrader, T.; Brsen, C.; Siebers, B.
Unraveling the function of paralogs of the aldehyde dehydrogenase super family from Sulfolobus solfataricus
Extremophiles
17
205-216
2013
Saccharolobus solfataricus (Q97XS9), Saccharolobus solfataricus
Puettmann, L.; Stehr, H.; Garshasbi, M.; Hu, H.; Kahrizi, K.; Lipkowitz, B.; Jamali, P.; Tzschach, A.; Najmabadi, H.; Ropers, H.H.; Musante, L.; Kuss, A.W.
A novel ALDH5A1 mutation is associated with succinic semialdehyde dehydrogenase deficiency and severe intellectual disability in an Iranian family
Am. J. Med. Genet. A
161A
1915-1922
2013
Homo sapiens (P51649), Homo sapiens
Kumar, S.; Kumar, S.; Punekar, N.S.
Characterization of succinic semialdehyde dehydrogenase from Aspergillus niger
Indian J. Exp. Biol.
53
67-74
2015
Aspergillus niger (A2R4V5), Aspergillus niger NCIM 565 (A2R4V5)
Tamazian, G.; Ho Chang, J.; Knyazev, S.; Stepanov, E.; Kim, K.J.; Porozov, Y.
Modeling conformational redox-switch modulation of human succinic semialdehyde dehydrogenase
Proteins
83
2217-2229
2015
Homo sapiens (P51649)
Hujber, Z.; Horvath, G.; Petoevari, G.; Krencz, I.; Danko, T.; Meszaros, K.; Rajnai, H.; Szoboszlai, N.; Leenders, W.P.J.; Jeney, A.; Tretter, L.; Sebestyen, A.
GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas
J. Exp. Clin. Cancer Res.
37
271
2018
Homo sapiens (P51649)
Brown, M.N.; Walters, D.C.; Schmidt, M.A.; Hill, J.; McConnell, A.; Jansen, E.E.W.; Salomons, G.S.; Arning, E.; Bottiglieri, T.; Gibson, K.M.; Roullet, J.B.
Maternal glutamine supplementation in murine succinic semialdehyde dehydrogenase deficiency, a disorder of gamma-aminobutyric acid metabolism
J. Inherit. Metab. Dis.
42
1030-1039
2019
Mus musculus (Q8BWF0), Mus musculus C57BL/6 (Q8BWF0)
Menduti, G.; Biamino, E.; Vittorini, R.; Vesco, S.; Puccinelli, M.P.; Porta, F.; Capo, C.; Leo, S.; Ciminelli, B.M.; Iacovelli, F.; Spada, M.; Falconi, M.; Malaspina, P.; Rossi, L.
Succinic semialdehyde dehydrogenase deficiency The combination of a novel ALDH5A1 gene mutation and a missense SNP strongly affects SSADH enzyme activity and stability
Mol. Genet. Metab.
124
210-215
2018
Homo sapiens (P51649)
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