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Information on EC 1.2.1.27 - methylmalonate-semialdehyde dehydrogenase (CoA-acylating)

for references in articles please use BRENDA:EC1.2.1.27
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IUBMB Comments
Also converts 3-oxopropanoate into acetyl-CoA . The reaction occurs in two steps with the decarboxylation process preceding CoA-binding . Bicarbonate rather than CO2 is released as a final product .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
msdh, mmsdh, methylmalonate semialdehyde dehydrogenase, odommsdh, methylmalonic acid semialdehyde dehydrogenase, mmsadh, sso1218, methylmalonate semialdehyde dehydrogenase protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH
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