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Information on EC 1.2.1.31 - L-aminoadipate-semialdehyde dehydrogenase
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1.2.1.31 L-aminoadipate-semialdehyde dehydrogenaseIUBMB Comments
(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction.
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Word Map
- 1.2.1.31
- epilepsy
- seizure
- pyridoxine
-
pyridoxine-dependent
-
beta-ars
-
pipecolic
-
alpha2-ars
-
antiepileptic
- phentolamine
-
folinic
- saccharopine
-
alpha-adrenoceptor
-
alpha2-adrenergic
-
seizure-free
-
lysine-restricted
-
rauwolscine
-
alpha1a-ar
- piperideine-6-carboxylate
-
alpha1a
- medicine
The enzyme appears in viruses and cellular organisms
Synonyms
aldh7a1, antiquitin, alpha-ar, aasadh, aldehyde dehydrogenase 7a1, alpha-aar, lys1p, alpha-aasa dehydrogenase, alpha-aminoadipic semialdehyde dehydrogenase, alpha-aminoadipate-semialdehyde dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
2-aminoadipate semialdehyde dehydrogenase
-
-
-
-
2-aminoadipic 6-semialdehyde dehydrogenase
2-aminoadipic semialdehyde dehydrogenase
-
-
-
-
Aldh7a1
alpha-AAR
alpha-AASA dehydrogenase
alpha-aminoadipate-semialdehyde dehydrogenase
-
-
-
-
alpha-aminoadipic acid-delta-semialdehyde dehydrogenase
alpha-aminoadipic semialdehyde dehydrogenase
Alpha-AR
-
-
-
-
antiquitin
dehydrogenase, aminoadipate semialdehyde
-
-
-
-
L-alpha-aminoadipate delta-semialdehyde oxidoreductase
-
-
-
-
L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase
-
-
-
-
L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase
-
-
-
-
L-aminoadipate-semialdehyde dehydrogenase
Nalpha-Z-L-AASA dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
-
-
-
-
reduction
oxidation
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction.
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CAS REGISTRY NUMBER
COMMENTARY
9067-87-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-2-amino-6-oxohexanoate + NAD+ + H2O
L-2-aminoadipate + NADH + H+
-
-
-
?
(S)-2-amino-6-oxohexanoate + NADP+ + H2O
L-2-aminoadipate + NADPH + H+
-
-
-
?
alpha-aminoadipate semialdehyde + NAD(P)+ + H2O
L-2-aminoadipate + NAD(P)H + H+
-
-
-
?
alpha-aminoadipate semialdehyde + NAD+ + H2O
alpha-aminoadipate + NADH + H+
-
-
-
-
?
alpha-aminoadipate semialdehyde + NADP+ + H2O
alpha-aminoadipate + NADPH + H+
-
-
-
-
?
L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O
L-2-aminoadipate + NAD(P)H + H+
-
-
-
?
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
L-alpha-aminoadipate + NAD(P)H + H+
-
-
-
-
?
Nalpha-benzyloxycarbonyl-L-aminoadipate-delta-semialdehyde + NAD+ + H2O
Nalpha-benzyloxycarbonyl-L-aminoadipate + NADH + H+
S-carboxymethyl-L-cysteine + NADPH
?
-
5% of the activity with L-2-aminoadipate
-
-
?
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NAD+ + H2O
L-2-aminoadipate + NADH
-
-
-
ir
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NAD+ + H2O
L-2-aminoadipate + NADH
-
-
-
ir
alpha-aminoadipic semialdehyde + NAD+ + H2O
alpha-aminoadipic acid + NADH + H+
-
-
-
-
?
alpha-aminoadipic semialdehyde + NAD+ + H2O
alpha-aminoadipic acid + NADH + H+
-
-
-
-
?
alpha-aminoadipic semialdehyde + NAD+ + H2O
alpha-aminoadipic acid + NADH + H+
-
-
-
-
?
alpha-aminoadipic semialdehyde + NAD+ + H2O
alpha-aminoadipic acid + NADH + H+
-
-
-
?
alpha-aminoadipic semialdehyde + NAD+ + H2O
alpha-aminoadipic acid + NADH + H+
-
-
-
-
?
alpha-aminoadipic semialdehyde + NAD+ + H2O
alpha-aminoadipic acid + NADH + H+
-
-
-
-
?
DELTA1-piperidine 6-carboxylate + NAD+ + H2O
L-alpha-aminoadipate + NADH + H+
-
-
-
-
r
DELTA1-piperidine 6-carboxylate + NAD+ + H2O
L-alpha-aminoadipate + NADH + H+
-
-
-
-
r
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
-
-
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP + Mg2+
-
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP + Mg2+
-
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP + Mg2+
-
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP + Mg2+
high specificity for L-alpha-aminoadipate-semialdehyde
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
-
-
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP + Mg2+
-
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP + Mg2+
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
-
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
-
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
presence of ATP required
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
-
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP
-
-
?
L-2-aminoadipate 6-semialdehyde + NAD+ + H2O
L-2-aminoadipate + NADH
-
-
-
ir
L-2-aminoadipate 6-semialdehyde + NAD+ + H2O
L-2-aminoadipate + NADH
-
-
-
ir
L-2-aminoadipate 6-semialdehyde + NAD+ + H2O
L-2-aminoadipate + NADH
-
-
-
ir
L-2-aminoadipate 6-semialdehyde + NAD+ + H2O
L-2-aminoadipate + NADH
-
-
-
?
L-2-aminoadipate-semialdehyde + NAD+
L-2-aminoadipate + NADH
-
degradative enzyme
-
?
L-2-aminoadipate-semialdehyde + NAD+
L-2-aminoadipate + NADH
-
mammalian degradation of hydroxy-L-lysine via phosphohydrolysine and 2-aminoadipic semialdehyde to 2-aminoadipic acid
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
-
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
sixth step of lysine biosynthesis
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
-
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
involved in lysine biosynthetic pathway
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
involved in lysine biosynthetic pathway
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
-
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
sixth step of lysine biosynthesis
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
sixth step of lysine biosynthesis
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
alpha-aminoadipate pathway for lysine biosynthesis
-
?
Nalpha-benzyloxycarbonyl-L-aminoadipate-delta-semialdehyde + NAD+ + H2O
Nalpha-benzyloxycarbonyl-L-aminoadipate + NADH + H+
-
-
-
-
?
Nalpha-benzyloxycarbonyl-L-aminoadipate-delta-semialdehyde + NAD+ + H2O
Nalpha-benzyloxycarbonyl-L-aminoadipate + NADH + H+
Rhodococcus sp. AIU Z-35-1
-
-
-
-
?
additional information
?
-
-
the enzyme catalyzes both the activation of alpha-aminoadipic acid and its reduction to semialdehyde
-
-
?
additional information
?
-
-
not: glutamate delta-semialdehyde DELTA1-pyrroline-5-carboxylate
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-2-amino-6-oxohexanoate + NAD+ + H2O
L-2-aminoadipate + NADH + H+
-
-
-
?
(S)-2-amino-6-oxohexanoate + NADP+ + H2O
L-2-aminoadipate + NADPH + H+
-
-
-
?
alpha-aminoadipate semialdehyde + NAD(P)+ + H2O
L-2-aminoadipate + NAD(P)H + H+
-
-
-
?
L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O
L-2-aminoadipate + NAD(P)H + H+
-
-
-
?
additional information
?
-
-
the enzyme catalyzes both the activation of alpha-aminoadipic acid and its reduction to semialdehyde
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
-
-
-
?
L-2-aminoadipate-semialdehyde + NAD+
L-2-aminoadipate + NADH
-
degradative enzyme
-
?
L-2-aminoadipate-semialdehyde + NAD+
L-2-aminoadipate + NADH
-
mammalian degradation of hydroxy-L-lysine via phosphohydrolysine and 2-aminoadipic semialdehyde to 2-aminoadipic acid
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
-
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
sixth step of lysine biosynthesis
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
-
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
involved in lysine biosynthetic pathway
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
involved in lysine biosynthetic pathway
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
-
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
sixth step of lysine biosynthesis
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
sixth step of lysine biosynthesis
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
alpha-aminoadipate pathway for lysine biosynthesis
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
a variety of NAD+ analogues serve as electron acceptor: deamino-NAD+, NADP+, thionicotinamide-NAD+ and 3-acetylpyridine-NAD+
-
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Cu2+
Mg2+
Mn2+
additional information
Mn2+
-
optimal concentration: 5 mM, 60% of the maximal activity attained with Mg2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
delta-hydroxylysine
-
competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH
additional information
-
dehydrogenase activity is not inhibited by Nalpha-Z-L-lysine and Nalpha-benzyloxycarbonyl-L-aminoadipate at pH 5.0 or 7.0
-
carbonyl reagents
-
e.g.: hydroxylamine, KCN, in the presence of substrate
-
L-lysine
-
competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH
S-(beta-aminoethyl)-L-cysteine
-
competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
11.2