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(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
aldh7a1, antiquitin, alpha-ar, aasadh, aldehyde dehydrogenase 7a1, alpha-aar, lys1p, alpha-aasa dehydrogenase, alpha-aminoadipic semialdehyde dehydrogenase, alpha-aminoadipate-semialdehyde dehydrogenase, more
(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+