Any feedback?
Information on EC 1.2.1.31 - L-aminoadipate-semialdehyde dehydrogenase
for references in articles please use BRENDA:EC1.2.1.31Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.2.1.31 L-aminoadipate-semialdehyde dehydrogenaseIUBMB Comments
(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction.
Specify your search results
Word Map
- 1.2.1.31
- epilepsy
- seizure
- pyridoxine
-
pyridoxine-dependent
-
beta-ars
-
pipecolic
-
alpha2-ars
-
antiepileptic
- phentolamine
-
folinic
- saccharopine
-
alpha-adrenoceptor
-
alpha2-adrenergic
-
seizure-free
-
lysine-restricted
-
rauwolscine
-
alpha1a-ar
- piperideine-6-carboxylate
-
alpha1a
- medicine
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
aldh7a1, antiquitin, alpha-ar, aasadh, aldehyde dehydrogenase 7a1, alpha-aar, lys1p, alpha-aasa dehydrogenase, alpha-aminoadipic semialdehyde dehydrogenase, alpha-aminoadipate-semialdehyde dehydrogenase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
2-aminoadipate semialdehyde dehydrogenase
-
-
-
-
2-aminoadipic 6-semialdehyde dehydrogenase
2-aminoadipic semialdehyde dehydrogenase
-
-
-
-
Aldh7a1
alpha-AAR
alpha-AASA dehydrogenase
alpha-aminoadipate-semialdehyde dehydrogenase
-
-
-
-
alpha-aminoadipic acid-delta-semialdehyde dehydrogenase
alpha-aminoadipic semialdehyde dehydrogenase
Alpha-AR
-
-
-
-
antiquitin
dehydrogenase, aminoadipate semialdehyde
-
-
-
-
L-alpha-aminoadipate delta-semialdehyde oxidoreductase
-
-
-
-
L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase
-
-
-
-
L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase
-
-
-
-
L-aminoadipate-semialdehyde dehydrogenase
Nalpha-Z-L-AASA dehydrogenase
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
-
-
-
-
reduction
oxidation
-
-
-
-
reduction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9067-87-2
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-2-amino-6-oxohexanoate + NAD+ + H2O
L-2-aminoadipate + NADH + H+
-
-
-
?
(S)-2-amino-6-oxohexanoate + NADP+ + H2O
L-2-aminoadipate + NADPH + H+
-
-
-
?
alpha-aminoadipate semialdehyde + NAD(P)+ + H2O
L-2-aminoadipate + NAD(P)H + H+
-
-
-
?
alpha-aminoadipate semialdehyde + NAD+ + H2O
alpha-aminoadipate + NADH + H+
-
-
-
-
?
alpha-aminoadipate semialdehyde + NADP+ + H2O
alpha-aminoadipate + NADPH + H+
-
-
-
-
?
L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O
L-2-aminoadipate + NAD(P)H + H+
-
-
-
?
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
L-alpha-aminoadipate + NAD(P)H + H+
-
-
-
-
?
Nalpha-benzyloxycarbonyl-L-aminoadipate-delta-semialdehyde + NAD+ + H2O
Nalpha-benzyloxycarbonyl-L-aminoadipate + NADH + H+
S-carboxymethyl-L-cysteine + NADPH
?
-
5% of the activity with L-2-aminoadipate
-
-
?
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NAD+ + H2O
L-2-aminoadipate + NADH
-
-
-
ir
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NAD+ + H2O
L-2-aminoadipate + NADH
-
-
-
ir
alpha-aminoadipic semialdehyde + NAD+ + H2O
alpha-aminoadipic acid + NADH + H+
-
-
-
-
?
alpha-aminoadipic semialdehyde + NAD+ + H2O
alpha-aminoadipic acid + NADH + H+
-
-
-
-
?
alpha-aminoadipic semialdehyde + NAD+ + H2O
alpha-aminoadipic acid + NADH + H+
-
-
-
-
?
alpha-aminoadipic semialdehyde + NAD+ + H2O
alpha-aminoadipic acid + NADH + H+
-
-
-
?
alpha-aminoadipic semialdehyde + NAD+ + H2O
alpha-aminoadipic acid + NADH + H+
-
-
-
-
?
alpha-aminoadipic semialdehyde + NAD+ + H2O
alpha-aminoadipic acid + NADH + H+
-
-
-
-
?
DELTA1-piperidine 6-carboxylate + NAD+ + H2O
L-alpha-aminoadipate + NADH + H+
-
-
-
-
r
DELTA1-piperidine 6-carboxylate + NAD+ + H2O
L-alpha-aminoadipate + NADH + H+
-
-
-
-
r
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
-
-
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP + Mg2+
-
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP + Mg2+
-
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP + Mg2+
-
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP + Mg2+
high specificity for L-alpha-aminoadipate-semialdehyde
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
-
-
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP + Mg2+
-
?
L-2-aminoadipate + NADPH
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP + Mg2+
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
-
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
-
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
presence of ATP required
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
-
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
in presence of ATP
-
-
?
L-2-aminoadipate 6-semialdehyde + NAD+ + H2O
L-2-aminoadipate + NADH
-
-
-
ir
L-2-aminoadipate 6-semialdehyde + NAD+ + H2O
L-2-aminoadipate + NADH
-
-
-
ir
L-2-aminoadipate 6-semialdehyde + NAD+ + H2O
L-2-aminoadipate + NADH
-
-
-
ir
L-2-aminoadipate 6-semialdehyde + NAD+ + H2O
L-2-aminoadipate + NADH
-
-
-
?
L-2-aminoadipate-semialdehyde + NAD+
L-2-aminoadipate + NADH
-
degradative enzyme
-
?
L-2-aminoadipate-semialdehyde + NAD+
L-2-aminoadipate + NADH
-
mammalian degradation of hydroxy-L-lysine via phosphohydrolysine and 2-aminoadipic semialdehyde to 2-aminoadipic acid
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
-
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
sixth step of lysine biosynthesis
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
-
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
involved in lysine biosynthetic pathway
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
involved in lysine biosynthetic pathway
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
-
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
sixth step of lysine biosynthesis
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
sixth step of lysine biosynthesis
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
alpha-aminoadipate pathway for lysine biosynthesis
-
?
Nalpha-benzyloxycarbonyl-L-aminoadipate-delta-semialdehyde + NAD+ + H2O
Nalpha-benzyloxycarbonyl-L-aminoadipate + NADH + H+
-
-
-
-
?
Nalpha-benzyloxycarbonyl-L-aminoadipate-delta-semialdehyde + NAD+ + H2O
Nalpha-benzyloxycarbonyl-L-aminoadipate + NADH + H+
Rhodococcus sp. AIU Z-35-1
-
-
-
-
?
additional information
?
-
-
the enzyme catalyzes both the activation of alpha-aminoadipic acid and its reduction to semialdehyde
-
-
?
additional information
?
-
-
not: glutamate delta-semialdehyde DELTA1-pyrroline-5-carboxylate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-2-amino-6-oxohexanoate + NAD+ + H2O
L-2-aminoadipate + NADH + H+
-
-
-
?
(S)-2-amino-6-oxohexanoate + NADP+ + H2O
L-2-aminoadipate + NADPH + H+
-
-
-
?
alpha-aminoadipate semialdehyde + NAD(P)+ + H2O
L-2-aminoadipate + NAD(P)H + H+
-
-
-
?
L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O
L-2-aminoadipate + NAD(P)H + H+
-
-
-
?
additional information
?
-
-
the enzyme catalyzes both the activation of alpha-aminoadipic acid and its reduction to semialdehyde
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation
-
-
?
L-2-aminoadipate + NADPH + H+
L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
-
-
-
?
L-2-aminoadipate-semialdehyde + NAD+
L-2-aminoadipate + NADH
-
degradative enzyme
-
?
L-2-aminoadipate-semialdehyde + NAD+
L-2-aminoadipate + NADH
-
mammalian degradation of hydroxy-L-lysine via phosphohydrolysine and 2-aminoadipic semialdehyde to 2-aminoadipic acid
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
-
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
sixth step of lysine biosynthesis
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
-
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
involved in lysine biosynthetic pathway
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
involved in lysine biosynthetic pathway
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
-
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
in presence of ATP and Mg2+
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
sixth step of lysine biosynthesis
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
sixth step of lysine biosynthesis
-
?
L-alpha-aminoadipate + NAD(P)H
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
alpha-aminoadipate pathway for lysine biosynthesis
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
a variety of NAD+ analogues serve as electron acceptor: deamino-NAD+, NADP+, thionicotinamide-NAD+ and 3-acetylpyridine-NAD+
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Cu2+
Mg2+
Mn2+
additional information
Mn2+
-
optimal concentration: 5 mM, 60% of the maximal activity attained with Mg2+
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
delta-hydroxylysine
-
competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH
additional information
-
dehydrogenase activity is not inhibited by Nalpha-Z-L-lysine and Nalpha-benzyloxycarbonyl-L-aminoadipate at pH 5.0 or 7.0
-
carbonyl reagents
-
e.g.: hydroxylamine, KCN, in the presence of substrate
-
L-lysine
-
competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH
S-(beta-aminoethyl)-L-cysteine
-
competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE