Any feedback?
Information on EC 1.2.1.4 - aldehyde dehydrogenase (NADP+)
for references in articles please use BRENDA:EC1.2.1.4Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.2.1.4 aldehyde dehydrogenase (NADP+)Specify your search results
Word Map
- 1.2.1.4
-
voltage-gated
-
kvbeta1
-
voltage-dependent
-
pore-forming
-
juxtaparanodal
-
paranodal
-
caspr
- medicine
- retinaldehyde
- synthesis
The enzyme appears in viruses and cellular organisms
Synonyms
kvbeta2, aldh6, nadp-dependent aldehyde dehydrogenase, taaldh, aldehyde dehydrogenase (nadp+), aldhpyr1147, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ALD6
aldehyde dehydrogenase (NADP+)
aldehyde dehydrogenase 3A1
aldehyde dehydrogenase 6
ALDH
ALDH1F1
ALDH3A1
ALDH6
AlDHPyr1147
dehydrogenase, aldehyde (nicotinamide adenine dinucleotide phosphate)
-
-
-
-
NADP+-dependent Ald6
NADP-acetaldehyde dehydrogenase
-
-
-
-
NADP-dependent aldehyde dehydrogenase
Ta0439
TaAlDH
NADP-dependent aldehyde dehydrogenase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an aldehyde + NADP+ + H2O = a carboxylate + NADPH + H+
random kinetic mechanism
-
an aldehyde + NADP+ + H2O = a carboxylate + NADPH + H+
random kinetic mechanism
-
-
an aldehyde + NADP+ + H2O = a carboxylate + NADPH + H+
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
-
-
-
-
reduction
oxidation
-
-
-
-
reduction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
aldehyde:NADP+ oxidoreductase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9028-87-9
-
97162-78-2
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-cyanobenzaldehyde + NADP+ + H2O
2-cyanobenzoate + NADPH + H+
-
3% activity compared to 4-nitrobenzaldehyde
-
-
?
2-methlybutyraldehyde + NADP+ + H2O
2-methylbutanoate + NADPH + H+
-
16% activity compared to 4-nitrobenzaldehyde
-
-
?
2-nitrobenzaldehyde + NADP+ + H2O
2-nitrobenzoate + NADPH + H+
-
22% activity compared to 4-nitrobenzaldehyde
-
-
?
3-nitrobenzaldehyde + NADP+ + H2O
3-nitrobenzoate + NADPH + H+
-
53% activity compared to 4-nitrobenzaldehyde
-
-
?
4-cyanobenzaldehyde + NADP+ + H2O
4-cyanobenzoate + NADPH + H+
-
6% activity compared to 4-nitrobenzaldehyde
-
-
?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
-
20% activity compared to 4-nitrobenzaldehyde
-
-
?
4-nitroacetophenone + NADP+ + H2O
?
-
2% activity compared to 4-nitrobenzaldehyde
-
-
?
4-nitrobenzaldehyde + NADP+ + H2O
4-nitrobenzoate + NADPH + H+
-
100% activity
-
-
?
butanal + NADP+ + H2O
butanoate + NADPH + H+
-
5% activity compared to 4-nitrobenzaldehyde
-
-
?
chloroacetaldehyde + NADP+ + H2O
chloroacetate + NADPH + H+
-
most effective substrate in the absence of Mg2+
-
-
?
crotonaldehyde + NADP+ + H2O
crotonate + NADPH + H+
-
2% activity compared to 4-nitrobenzaldehyde
-
-
?
glutaraldehyde + NADP+ + H2O
glutarate + NADPH + H+
-
-
-
-
?
hexanal + NADP+ + H2O
hexanoate + NADPH + H+
-
1% activity compared to 4-nitrobenzaldehyde
-
-
?
isobutanal + NADP+
isobutyrate + NADPH
-
19% of the activity with acetaldehyde
-
-
ir
methylglyoxal + NADP+ + H2O
?
-
7% activity compared to 4-nitrobenzaldehyde
-
-
?
phenylglyoxal + NADP+ + H2O
?
-
3% activity compared to 4-nitrobenzaldehyde
-
-
?
succinic semialdehyde + NADP+ + H2O
?
-
5% activity compared to 4-nitrobenzaldehyde
-
-
?
trans,trans-muconaldehyde + NADP+ + H2O
trans,trans-muconic acid + NADPH + H+
-
-
-
?
valeraldehyde + NADP+ + H2O
pentanoate + NADPH + H+
-
1% activity compared to 4-nitrobenzaldehyde
-
-
?
4-hydroxy-2-nonenal + NADP+ + H2O
(2E)-4-hydroxynon-2-enoate + NADPH + H+
-
-
-
-
?
4-hydroxy-2-nonenal + NADP+ + H2O
(2E)-4-hydroxynon-2-enoate + NADPH + H+
-
-
-
-
?
4-hydroxy-2-nonenal + NADP+ + H2O
(2E)-4-hydroxynon-2-enoate + NADPH + H+
-
-
-
-
?
acetaldehyde + NADP+
?
Acetobacter acetigenus
-
enzyme is involved in assimilation of ethanol
-
-
?
acetaldehyde + NADP+
?
-
enzyme is involved in assimilation of ethanol
-
-
?
acetaldehyde + NADP+
?
-
enzyme is involved in assimilation of ethanol
-
-
?
acetaldehyde + NADP+
?
-
enzyme is involved in assimilation of ethanol
-
-
?
acetaldehyde + NADP+
?
-
enzyme is involved in assimilation of ethanol
-
-
?
acetaldehyde + NADP+
?
-
enzyme is involved in assimilation of ethanol
-
-
?
acetaldehyde + NADP+
?
-
enzyme is involved in assimilation of ethanol
-
-
?
acetaldehyde + NADP+
?
-
enzyme is involved in assimilation of ethanol
-
-
?
acetaldehyde + NADP+
?
Gluconobacter gluconicus
-
enzyme is involved in assimilation of ethanol
-
-
?
acetaldehyde + NADP+
?
-
enzyme is involved in assimilation of ethanol
-
-
?
acetaldehyde + NADP+
?
-
enzyme is involved in assimilation of ethanol
-
-
?
acetaldehyde + NADP+
?
-
enzyme is involved in assimilation of ethanol
-
-
?
acetaldehyde + NADP+
acetate + NADPH + H+
-
-
-
?
acetaldehyde + NADP+ + H2O
acetate + NADPH + H+
-
enzyme a, b, c, d and e
-
-
?
acetaldehyde + NADP+ + H2O
acetate + NADPH + H+
-
131% of the activity with isovaleraldehyde
-
-
?
an aldehyde + NADP+ + H2O
an acid + NADPH + H+
-
removal of aldehydes and alcohols in cells under stress
-
-
?
benzaldehyde + NADP+
benzoate + NADPH
-
l40% of the activity with acetaldehyde
-
-
?
benzaldehyde + NADP+
benzoate + NADPH
-
6% of the activity with isovaleraldehyde
-
-
?
benzaldehyde + NADP+ + H2O
benzoate + NADPH + H+
-
8% activity compared to 4-nitrobenzaldehyde
-
-
?
butanal + NADP+ + H2O
butyrate + NADPH + H+
-
n-butanal, enzyme a, b, c, d and e
-
-
?
butanal + NADP+ + H2O
butyrate + NADPH + H+
-
n-butanal, 2% of the activity with acetaldehyde
-
-
ir
D-glyceraldehyde + NADP+
D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde + NADP+
D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde + NADP+
D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde + NADP+
D-glycerate + NADPH + H+
-
-
-
?
formaldehyde + NADP+
formate + NADPH + H+
-
-
-
?
formaldehyde + NADP+ + H2O
formate + NADPH + H+
-
weak activity with enzyme a, b, d and e
-
-
?
formaldehyde + NADP+ + H2O
formate + NADPH + H+
-
low activity
-
-
?
formaldehyde + NADP+ + H2O
formate + NADPH + H+
-
low activity
-
-
?
formaldehyde + NADP+ + H2O
formate + NADPH + H+
-
2% of the activity with acetaldehyde
-
-
ir
glyceraldehyde + NADP+ + H2O
glycerate + NADPH + H+
-
-
-
-
?
glyceraldehyde + NADP+ + H2O
glycerate + NADPH + H+
-
-
-
ir
glyceraldehyde + NADP+ + H2O
glycerate + NADPH + H+
-
-
-
ir
isobutyraldehyde + NADP+ + H2O
isobutyrate + NADPH + H+
-
-
-
ir
isobutyraldehyde + NADP+ + H2O
isobutyrate + NADPH + H+
-
-
-
ir
octanal + NADP+ + H2O
octanoate + NADPH + H+
-
n-octanal, enzyme b, c, d and e
-
-
?
pentanal + NADP+
pentanoate + NADPH
-
n-pentanal, enzyme a, b, c, d and e
-
-
?
propanal + NADP+ + H2O
propionate + NADPH + H+
-
enzyme a, b, c, d and e
-
-
?
propanal + NADP+ + H2O
propionate + NADPH + H+
-
much lower activity than with acetaldehyde
-
-
?
propanal + NADP+ + H2O
propionate + NADPH + H+
-
102% of the activity with acetaldehyde
-
-
ir
propanal + NADP+ + H2O
propionate + NADPH + H+
-
181% of the activity with isovaleraldehyde
-
-
?
propionaldehyde + NADP+ + H2O
propanoate + NADPH + H+
-
-
-
-
?
propionaldehyde + NADP+ + H2O
propanoate + NADPH + H+
-
-
-
ir
propionaldehyde + NADP+ + H2O
propanoate + NADPH + H+
-
-
-
ir
additional information
?
-
-
the constitutive enzyme may function in the intracellular detoxification of short chain aldehydes by conversion to corresponding fatty acids
-
-
?
additional information
?
-
-
the constitutive enzyme may function in the intracellular detoxification of short chain aldehydes by conversion to corresponding fatty acids
-
-
?
additional information
?
-
-
enzyme is involved in the oxidation of alkanes
-
-
?
additional information
?
-
-
no activity with glycolaldehyde and glyceraldehyde
-
-
?
additional information
?
-
no activity with phenylacetaldehyde, chlorobenzaldehyde, betaine aldehyde and succinic semialdehyde
-
-
?
additional information
?
-
no activity with phenylacetaldehyde, chlorobenzaldehyde, betaine aldehyde and succinic semialdehyde
-
-
?
additional information
?
-
-
no activity with 4-chlorobenzaldehyde, 4-fluorbenzaldehyde, tolualdehyde, anisaldehyde, formaldehyde, octanal, cinnamaldehyde, and isatin
-
-
?
additional information
?
-
-
enzyme is partly repressed during growth on glucose
-
-
?
additional information
?
-
NADH/formaldehyde detection by luminescence assay using Vibrio fischeri
-
-
-
additional information
?
-
NADH/formaldehyde detection by luminescence assay using Vibrio fischeri
-
-
-
additional information
?
-
no activity with acetaldehyde
-
-
-
additional information
?
-
no activity with acetaldehyde
-
-
-
additional information
?
-
no activity with acetaldehyde
-
-
-
additional information
?
-
no activity with acetaldehyde
-
-
-
additional information
?
-
no activity with acetaldehyde
-
-
-