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IUBMB CommentsThe enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.
The enzyme appears in viruses and cellular organisms
Synonyms
fluoroacetaldehyde dehydrogenase,
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fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+
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fluoroacetaldehyde:NAD+ oxidoreductase
The enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.
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acetaldehyde + NAD+ + H2O
acetate + NADH + H+
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
chloroacetaldehyde + NAD+ + H2O
chloroacetate + NADH + H+
DL-glyceraldehyde + NAD+ + H2O
DL-glycerate + NADH + H+
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10% of activity with fluoroacetaldehyde
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fluroracetaldehyde + NAD+ + H2O
fluoroacetate + NADH
fluroracetaldehyde + NAD+ + H2O
fluoroacetate + NADH + H+
glycoaldehyde + NAD+ + H2O
glycolate + NADH + H+
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150% of activity with fluoroacetaldehyde
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propionaldehyde + NAD+ + H2O
propionate + NADH + H+
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
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40% of activity with fluoroacetaldehyde
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acetaldehyde + NAD+ + H2O
acetate + NADH + H+
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40% of activity with fluoroacetaldehyde
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benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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65% of activity with fluoroacetaldehyde
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benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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65% of activity with fluoroacetaldehyde
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chloroacetaldehyde + NAD+ + H2O
chloroacetate + NADH + H+
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80% of activity with fluoroacetaldehyde, inactivation upon extended incubation
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chloroacetaldehyde + NAD+ + H2O
chloroacetate + NADH + H+
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80% of activity with fluoroacetaldehyde, inactivation upon extended incubation
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fluroracetaldehyde + NAD+ + H2O
fluoroacetate + NADH
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fluroracetaldehyde + NAD+ + H2O
fluoroacetate + NADH
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involved in fluorometabolite biosynthesis
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fluroracetaldehyde + NAD+ + H2O
fluoroacetate + NADH
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fluroracetaldehyde + NAD+ + H2O
fluoroacetate + NADH + H+
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fluroracetaldehyde + NAD+ + H2O
fluoroacetate + NADH + H+
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fluroracetaldehyde + NAD+ + H2O
fluoroacetate + NADH + H+
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fluroracetaldehyde + NAD+ + H2O
fluoroacetate + NADH + H+
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propionaldehyde + NAD+ + H2O
propionate + NADH + H+
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28% of activity with fluoroacetaldehyde
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propionaldehyde + NAD+ + H2O
propionate + NADH + H+
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28% of activity with fluoroacetaldehyde
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?
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fluroracetaldehyde + NAD+ + H2O
fluoroacetate + NADH
fluroracetaldehyde + NAD+ + H2O
fluoroacetate + NADH
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fluroracetaldehyde + NAD+ + H2O
fluoroacetate + NADH
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involved in fluorometabolite biosynthesis
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fluroracetaldehyde + NAD+ + H2O
fluoroacetate + NADH
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Chloroacetaldehyde
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0.25 mM, time-dependent inactivation
Cu2+
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1 mM, strong inhibition
iodoacetamide
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0.05 mM, strong inhibition
Mg2+
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1 mM, 80% loss of activity, possibly due to a decreased dissociation rate of NADH from the enzyme
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EDTA
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1 mM, increase in activity
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0.08
fluoroacetaldehyde
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NRRL 8057
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brenda
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brenda
NRRL 8057
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brenda
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FLUDE_STREN
Streptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057)
507
0
54570
Swiss-Prot
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A0A3Q9J965_9MICO
521
0
56574
TrEMBL
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A0A7K0D8W2_9NOCA
Nocardia macrotermitis
505
0
54361
TrEMBL
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A0A387HPA7_9ACTN
507
0
55599
TrEMBL
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A0A3Q9JGQ0_9MICO
516
0
56056
TrEMBL
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55000
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4 * 55000, SDS-PAGE
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tetramer
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4 * 55000, SDS-PAGE
tetramer
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4 * 55000, SDS-PAGE
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ammonium sulfate, anion-exchange, 5'-AMP-agarose
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Murphy, C.D.; Moss, S.J.; O'Hagan, D.
Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya
Appl. Environ. Microbiol.
67
4919-4921
2001
Streptomyces cattleya, Streptomyces cattleya NRRL 8057
brenda
Murphy, C.D.; Schaffrath, C.; O'Hagan, D.
Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya
Chemosphere
52
455-461
2003
Streptomyces cattleya
brenda
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1.2.1.69 fluoroacetaldehyde dehydrogenase
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