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Information on EC - glutamyl-tRNA reductase

for references in articles please use BRENDA:EC1.2.1.70
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EC Tree
IUBMB Comments
This enzyme forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway. The route shown in the diagram is used in most eubacteria, and in all archaebacteria, algae and plants. However, in the alpha-proteobacteria, EC, 5-aminolevulinate synthase, is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine. This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic alpha-proteobacterium. Although higher plants do not possess EC, the protistan Euglena gracilis possesses both the C5 pathway and EC
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Word Map
The enzyme appears in viruses and cellular organisms
glutamyl-trna reductase, glutr, hema1, hema2, athema1, more
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu = L-glutamyl-tRNAGlu + NADPH + H+
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