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Information on EC 1.2.1.83 - 3-succinoylsemialdehyde-pyridine dehydrogenase for references in articles please use BRENDA:EC1.2.1.83Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The expected taxonomic range for this enzyme is: Pseudomonas
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3-succinoylsemialdehyde-pyridine dehydrogenase
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4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O = 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+
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nicotine degradation II (pyrrolidine pathway)
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nicotine degradation IV
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Nicotinate and nicotinamide metabolism
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Microbial metabolism in diverse environments
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4-oxo-4-(pyridin-3-yl)butanal:NADP+ oxidoreductase
The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6. It participates in the nicotine degradation pathway.
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ALD
gene name
SapD
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UniProt
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UniProt
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physiological function
an enzyme deletion strain is still able to grow on pseudoxynicotine, the cell growth and the rate of pseudoxynicotine removal are initially slightly reduced. After the deletion strain is cultured with pseudoxynicotine for several generations, the pseudoxynicotine degradation characteristics reach the wild-type level
physiological function
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an enzyme deletion strain is still able to grow on pseudoxynicotine, the cell growth and the rate of pseudoxynicotine removal are initially slightly reduced. After the deletion strain is cultured with pseudoxynicotine for several generations, the pseudoxynicotine degradation characteristics reach the wild-type level
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4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O
4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+
4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O
4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+
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4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O
4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+
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additional information
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no cofactor: NAD+
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additional information
no cofactor: NAD+
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expression in Escherichia coli
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Qiu, J.; Ma, Y.; Wen, Y.; Chen, L.; Wu, L.; Liu, W.
Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine
Appl. Environ. Microbiol.
78
2154-2160
2012
Pseudomonas sp., Pseudomonas sp. (H8ZPX2), Pseudomonas sp. HZN6 (H8ZPX2)
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