Information on EC 1.2.1.98 - 2-hydroxy-2-methylpropanal dehydrogenase

for references in articles please use BRENDA:EC1.2.1.98
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The expected taxonomic range for this enzyme is: Mycobacterium austroafricanum

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EC NUMBER
COMMENTARY hide
1.2.1.98
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RECOMMENDED NAME
GeneOntology No.
2-hydroxy-2-methylpropanal dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-hydroxy-2-methylpropanal + NAD+ + H2O = 2-hydroxyisobutanoate + NADH + H+
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
2-methylpropene degradation
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methyl tert-butyl ether degradation
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SYSTEMATIC NAME
IUBMB Comments
2-hydroxy-2-methylpropanal:NAD+ oxidoreductase
This bacterial enzyme is involved in the degradation pathways of the alkene 2-methylpropene and the fuel additive tert-butyl methyl ether (MTBE), a widely occurring groundwater contaminant.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-hydroxy-2-methylpropanal + NAD+ + H2O
2-hydroxy-2-methylpropanoate + NADH + H+
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-hydroxy-2-methylpropanal + NAD+ + H2O
2-hydroxy-2-methylpropanoate + NADH + H+
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
55000
x * 55000, SDS-PAGE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.2.1.98)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)