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IUBMB Comments This bacterial enzyme is involved in the degradation pathways of the alkene 2-methylpropene and the fuel additive tert-butyl methyl ether (MTBE), a widely occurring groundwater contaminant.
The enzyme appears in viruses and cellular organisms
Synonyms
hydroxyisobutyraldehyde dehydrogenase,
mpdC ,
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hydroxyisobutyraldehyde dehydrogenase
hydroxyisobutyraldehyde dehydrogenase
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hydroxyisobutyraldehyde dehydrogenase
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mpdC
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2-hydroxy-2-methylpropanal + NAD+ + H2O = 2-hydroxy-2-methylpropanoate + NADH + H+
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2-hydroxy-2-methylpropanal:NAD+ oxidoreductase
This bacterial enzyme is involved in the degradation pathways of the alkene 2-methylpropene and the fuel additive tert-butyl methyl ether (MTBE), a widely occurring groundwater contaminant.
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2-hydroxy-2-methylpropanal + NAD+ + H2O
2-hydroxy-2-methylpropanoate + NADH + H+
2-hydroxy-2-methylpropanal + NAD+ + H2O
2-hydroxy-2-methylpropanoate + NADH + H+
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2-hydroxy-2-methylpropanal + NAD+ + H2O
2-hydroxy-2-methylpropanoate + NADH + H+
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2-hydroxy-2-methylpropanal + NAD+ + H2O
2-hydroxy-2-methylpropanoate + NADH + H+
2-hydroxy-2-methylpropanal + NAD+ + H2O
2-hydroxy-2-methylpropanoate + NADH + H+
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2-hydroxy-2-methylpropanal + NAD+ + H2O
2-hydroxy-2-methylpropanoate + NADH + H+
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UniProt
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UniProt
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MPDC_MYCAO
504
0
53848
Swiss-Prot
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A0A6J5GVC1_9BURK
424
0
44596
TrEMBL
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A0A653LF13_9MICC
500
0
53619
TrEMBL
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A0A6J5H2V6_9BURK
424
0
44611
TrEMBL
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A0A653XB98_9ACTN
494
0
52562
TrEMBL
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55000
x * 55000, SDS-PAGE
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x * 55000, SDS-PAGE
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x * 55000, SDS-PAGE
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Lopes Ferreira, N.; Labbe, D.; Monot, F.; Fayolle-Guichard, F.; Greer, C.W.
Genes involved in the methyl tert-butyl ether (MTBE) metabolic pathway of Mycobacterium austroafricanum IFP 2012
Microbiology
152
1361-1374
2006
Mycolicibacterium austroafricanum (Q3YAT5), Mycolicibacterium austroafricanum IFP 2012 (Q3YAT5)
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History
Enzyme Nomenclature
1.2.1.98 2-hydroxy-2-methylpropanal dehydrogenase
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