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Information on EC 1.2.7.1 - pyruvate synthase

for references in articles please use BRENDA:EC1.2.7.1

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IUBMB Comments

Contains thiamine diphosphate and [4Fe-4S] clusters. The enzyme also decarboxylates 2-oxobutyrate with lower efficiency, but shows no activity with 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
pyruvate:ferredoxin oxidoreductase, pyruvate ferredoxin oxidoreductase, pyruvate-ferredoxin oxidoreductase, pyruvate synthase, pfo a, ap120, pfora, pfor1, nifj1, pyruvate:ferredoxin oxidoreductase a, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
pyruvate + CoA + oxidized ferredoxin = acetyl-CoA + CO2 + reduced ferredoxin + 2 H+
show the reaction diagram
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