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Information on EC - formylmethanofuran dehydrogenase

for references in articles please use BRENDA:EC1.2.7.12
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IUBMB Comments
Contains a molybdopterin cofactor and numerous [4Fe-4S] clusters. In some organisms an additional subunit enables the incorporation of tungsten when molybdenum availability is low. The enzyme catalyses a reversible reaction in methanogenic archaea, and is involved in methanogenesis from CO2 as well as the oxidation of coenzyme M to CO2. The reaction is endergonic, and is driven by coupling with the soluble CoB-CoM heterodisulfide reductase via electron bifurcation.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
formylmethanofuran dehydrogenase, formyl-methanofuran dehydrogenase, pf02663, formyl-mfr dehydrogenase, more
a formylmethanofuran + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster = CO2 + a methanofuran + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
show the reaction diagram