Disease on EC 1.2.99.6 - carboxylate reductase
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Acquired Immunodeficiency Syndrome
Direct enzyme assay evidence confirms aldehyde reductase function of Ydr541cp and Ygl039wp from Saccharomyces cerevisiae.
Astrocytoma
The role of aldehyde reductase AKR1A1 in the metabolism of gamma-hydroxybutyrate in 1321N1 human astrocytoma cells.
Carcinogenesis
A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant.
Carcinogenesis
Glutathione-S-transferase, alcohol dehydrogenase and aldehyde reductase activities during diethylnitrosamine-carcinogenesis in rat liver.
Carcinogenesis
Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat.
Carcinoma
Increased resistance of tumor cells to daunorubicin after transfection of cDNAs coding for anthracycline inactivating enzymes.
Carcinoma, Hepatocellular
Glutathione-S-transferase, alcohol dehydrogenase and aldehyde reductase activities during diethylnitrosamine-carcinogenesis in rat liver.
Carcinoma, Hepatocellular
Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1).
Carcinoma, Hepatocellular
Role of aldehyde metabolizing enzymes in mediating effects of aldehyde products of lipid peroxidation in liver cells.
Carcinoma, Hepatocellular
Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue.
Cataract
Lens aldehyde reductase and dehydrogenase, and their possible involvement in diabetes and cataract formation.
Colorectal Neoplasms
Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.
Diabetes Complications
Expression of human aldose and aldehyde reductases. Site-directed mutagenesis of a critical lysine 262.
Diabetes Complications
Molecular modelling and synthesis of spiroimidazolidine-2,4-diones with dual activities as hypoglycemic agents and selective inhibitors of aldose reductase.
Diabetes Complications
Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.
Diabetes Complications
Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies.
Diabetes Complications
Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications.
Diabetes Mellitus
Coumarin-thiazole and -oxadiazole derivatives: Synthesis, bioactivity and docking studies for aldose/aldehyde reductase inhibitors.
Diabetic Neuropathies
X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: Implications for inhibitor binding and selectivity.
Hepatitis
Induction of aldose reductase gene expression in LEC rats during the development of the hereditary hepatitis and hepatoma.
Hypernatremia
The role of polyols in cerebral cell volume regulation in hypernatremic and hyponatremic states.
Hyponatremia
The role of polyols in cerebral cell volume regulation in hypernatremic and hyponatremic states.
Infections
Genome sequence and transcriptome profiles of pathogenic fungus Paecilomyces penicillatus reveal its interactions with edible fungus Morchella importuna.
Laryngeal Neoplasms
Increased aldehyde reductase expression mediates acquired radioresistance of laryngeal cancer cells via modulating p53.
Leukemia, Myeloid
NADPH-dependent reductases and polyol formation in human leukemia cell lines.
Leukemia, Myeloid, Acute
[Induction of cell differentiation and development of new anticancer drugs]
Metabolic Diseases
Coumarin-thiazole and -oxadiazole derivatives: Synthesis, bioactivity and docking studies for aldose/aldehyde reductase inhibitors.
Neoplasms
Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.
Neoplasms
Differential protein expression in honeybee (Apis mellifera L.) larvae: underlying caste differentiation.
Neoplasms
Genetic variation of Aflatoxin B(1) aldehyde reductase genes (AFAR) in human tumour cells.
Neoplasms
In silico designing of novel inhibitors for triple inhibition of Aldose Reductase, Aldose Reductase like protein 1, and Aldehyde Reductase.
Neoplasms
Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma.
Obesity
[Aldehyde reductase activity and blood aldo-keto reductase spectrum in adolescents with neuroendocrine obesity].
Pancreatic Neoplasms
Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma.
Sarcoma, Experimental
Purification and properties of aldose reductase and aldehyde reductase from EHS tumor cells.
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