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Information on EC 1.3.1.112 - anthocyanidin reductase [(2S)-flavan-3-ol-forming]

for references in articles please use BRENDA:EC1.3.1.112

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IUBMB Comments

The enzyme, characterized from Vitis vinifera (grape), participates in the flavonoid biosynthesis pathway. It catalyses the double reduction of anthocyanidins, producing a mixture of (2S,3S)- and (2S,3R)-flavan-3-ols. The enzyme catalyses sequential hydride transfers to C-2 and C-4, respectively. Epimerization at C-3 is achieved by tautomerization that occurs between the two hydride transfers. cf. EC 1.3.1.77, anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming].

The enzyme appears in viruses and cellular organisms

Synonyms
ANR, anthocyanidin reductase ((2S)-flavan-3-ol-forming), more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (2S,3R)-flavan-3-ol + 2 NADP+ = an anthocyanidin with a 3-hydroxy group + 2 NADPH + H+
show the reaction diagram
(1)
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a (2S,3S)-flavan-3-ol + 2 NADP+ = an anthocyanidin with a 3-hydroxy group + 2 NADPH + H+
show the reaction diagram
(2)
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