Information on EC 1.3.1.117 - hydroxycinnamoyl-CoA reductase

for references in articles please use BRENDA:EC1.3.1.117
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The expected taxonomic range for this enzyme is: Malus domestica

EC NUMBER
COMMENTARY hide
1.3.1.117
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RECOMMENDED NAME
GeneOntology No.
hydroxycinnamoyl-CoA reductase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dihydro-4-coumaroyl-CoA + NADP+ = trans-4-coumaroyl-CoA + NADPH + H+
show the reaction diagram
(1)
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-
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dihydroferuloyl-CoA + NADP+ = trans-feruloyl-CoA + NADPH + H+
show the reaction diagram
(2)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
flavonoid di-C-glucosylation
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phloridzin biosynthesis
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Flavonoid biosynthesis
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Biosynthesis of secondary metabolites
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SYSTEMATIC NAME
IUBMB Comments
dihydro-4-coumaroyl-CoA:NADP+ 2,3-oxidoreductase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
trans-4-coumaroyl-CoA + NADPH + H+
dihydro-4-coumaroyl-CoA + NADP+
show the reaction diagram
trans-feruloyl-CoA + NADPH + H+
dihydroferuloyl-CoA + NADP+
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
trans-4-coumaroyl-CoA + NADPH + H+
dihydro-4-coumaroyl-CoA + NADP+
show the reaction diagram
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enzyme prefers feruloyl-CoA to p-coumaroyl-CoA by a factor of 2.1
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-
?
trans-feruloyl-CoA + NADPH + H+
dihydroferuloyl-CoA + NADP+
show the reaction diagram
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enzyme prefers feruloyl-CoA to p-coumaroyl-CoA by a factor of 2.1
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.101
NADPH
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pH 50, 35C
0.097
trans-4-coumaroyl-CoA
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pH 50, 35C
0.093
trans-feruloyl-CoA
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pH 50, 35C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0023
NADPH
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pH 50, 35C
0.0019
trans-4-coumaroyl-CoA
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pH 50, 35C
0.0042
trans-feruloyl-CoA
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pH 50, 35C
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.9
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calculated from sequence
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 38400, SDS-PAGE and calculated from sequence
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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