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Information on EC 1.3.1.118 - meromycolic acid enoyl-[acyl-carrier-protein] reductase

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IUBMB Comments
InhA is a component of the fatty acid synthase (FAS) II system of Mycobacterium tuberculosis, catalysing an enoyl-[acyl-carrier-protein] reductase step. The enzyme acts on very long and unsaturated fatty acids that form the meromycolic component of mycolic acids. It extends FASI-derived C20 fatty acids to form C60 to C90 mycolic acids. The enzyme, which forms a homotetramer, is the target of the preferred antitubercular drug isoniazid.
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The expected taxonomic range for this enzyme is: Mycobacteriaceae
Synonyms
inha protein, enoyl-acp reductase inha, 2-trans-enoyl-acyl carrier protein reductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a meromycolyl-[acyl-carrier protein] + NAD+ = a trans-DELTA2-meromycolyl-[acyl-carrier protein] + NADH + H+
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PATHWAY SOURCE
PATHWAYS
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