Reference on EC 1.3.1.118 - meromycolic acid enoyl-[acyl-carrier-protein] reductase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nguyen, M.; Quemard, A.; Broussy, S.; Bernadou, J.; Meunier, B.
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis
Antimicrob. Agents Chemother.
46
2137-2144
2002
Mycobacterium tuberculosis
Quemard, A.; Sacchettini, J.; Dessen, A.; Vilcheze, C.; Bittman, R.; Jacobs, W.J.; Blanchard, J.
Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis
Biochemistry
34
8235-8241
1995
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Joshi, S.; Dixit, S.; Basha, J.; Kulkarni, V.; Aminabhavi, T.; Nadagouda, M.; Lherbet, C.
Pharmacophore mapping, molecular docking, chemical synthesis of some novel pyrrolyl benzamide derivatives and evaluation of their inhibitory activity against enoyl-ACP reductase (InhA) and Mycobacterium tuberculosis
Bioorg. Chem.
81
440-453
2018
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis H37Rv (P9WGR1)
He, X.; Alian, A.; Ortiz de Montellano, P.
Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides
Bioorg. Med. Chem.
15
6649-6658
2007
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Schroeder, E.; Basso, L.; Santos, D.; De Souza, O.
Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH Toward the understanding of NADH-InhA different affinities
Biophys. J.
89
876-884
2005
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Subba Rao, G.; Vijayakrishnan, R.; Kumar, M.
Structure-based design of a novel class of potent inhibitors of InhA, the enoyl acyl carrier protein reductase from Mycobacterium tuberculosis A computer modelling approach
Chem. Biol. Drug Des.
72
444-449
2008
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Nguyen, M.; Quemard, A.; Marrakchi, H.; Bernadou, J.; Meunier, B.
The nonenzymatic activation of isoniazid by MnIII-pyrophosphate in the presence of NADH produces the inhibition of the enoyl-ACP reductase InhA from Mycobacterium tuberculosis
Chemistry
4
35-40
2001
Mycobacterium tuberculosis
-
Guardia, A.; Gulten, G.; Fernandez, R.; Gomez, J.; Wang, F.; Convery, M.; Blanco, D.; Martinez, M.; Perez-Herran, E.; Alonso, M.; Ortega, F.; Rullas, J.; Calvo, D.; Mata, L.; Young, R.; Sacchettini, J.; Mendoza-Losana, A.; Remuinan, M.
N-Benzyl-4-((heteroaryl)methyl)benzamides a new class of direct NADH-dependent 2-trans enoyl-acyl carrier protein reductase (InhA) inhibitors with antitubercular activity
ChemMedChem
11
687-701
2016
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Pan, P.; Tonge, P.
Targeting InhA, the FASII enoyl-ACP reductase SAR studies on novel inhibitor scaffolds
Curr. Top. Med. Chem.
12
672-693
2012
Mycobacterium tuberculosis
Chollet, A.; Maveyraud, L.; Lherbet, C.; Bernardes-Genisson, V.
An overview on crystal structures of InhA protein Apo-form, in complex with its natural ligands and inhibitors
Eur. J. Med. Chem.
146
318-343
2018
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Pedgaonkar, G.; Sridevi, J.; Jeankumar, V.; Saxena, S.; Devi, P.; Renuka, J.; Yogeeswari, P.; Sriram, D.
Development of 2-(4-oxoquinazolin-3(4H)-yl)acetamide derivatives as novel enoyl-acyl carrier protein reductase (InhA) inhibitors for the treatment of tuberculosis
Eur. J. Med. Chem.
86
613-627
2014
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Rotta, M.; Pissinate, K.; Villela, A.; Back, D.; Timmers, L.; Bachega, J.; De Souza, O.; Santos, D.; Basso, L.; Machado, P.
Piperazine derivatives Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase and SAR studies
Eur. J. Med. Chem.
90
436-447
2015
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Argyrou, A.; Vetting, M.; Blanchard, J.
New insight into the mechanism of action of and resistance to isoniazid Interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP
J. Am. Chem. Soc.
129
9582-9583
2007
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Spagnuolo, L.; Eltschkner, S.; Yu, W.; Daryaee, F.; Davoodi, S.; Knudson, S.; Allen, E.; Merino, J.; Pschibul, A.; Moree, B.; Thivalapill, N.; Truglio, J.; Salafsky, J.; Slayden, R.; Kisker, C.; Tonge, P.
Evaluating the contribution of transition-state destabilization to changes in the residence time of triazole-based InhA inhibitors
J. Am. Chem. Soc.
139
3417-3429
2017
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Vilcheze, C.; Morbidoni, H.; Weisbrod, T.; Iwamoto, H.; Kuo, M.; Sacchettini, J.; Jacobs Jr., W.
Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis
J. Bacteriol.
182
4059-4067
2000
Mycolicibacterium smegmatis (P42829), Mycolicibacterium smegmatis mc(2)155 (P42829)
Rozwarski, D.; Vilcheze, C.; Sugantino, M.; Bittman, R.; Sacchettini, J.
Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate
J. Biol. Chem.
274
15582-15598
1999
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Luckner, S.; Liu, N.; Am Ende, C.; Tonge, P.; Kisker, C.
A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis
J. Biol. Chem.
285
14330-14337
2010
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Vasconcelos, I.; Basso, L.; Santos, D.
Kinetic and equilibrium mechanisms of substrate binding to Mycobacterium tuberculosis enoyl reductase Implications to function-based antitubercular agent design
J. Braz. Chem. Soc.
21
1503-1508
2010
Mycobacterium tuberculosis
-
Da Costa, A.; Pauli, I.; Dorn, M.; Schroeder, E.; Zhan, C.; De Souza, O.
Conformational changes in 2-trans-enoyl-ACP (CoA) reductase (InhA) from M. tuberculosis induced by an inorganic complex A molecular dynamics simulation study
J. Mol. Model.
18
1779-1790
2012
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Gurvitz, A.
Triclosan inhibition of mycobacterial InhA in Saccharomyces cerevisiae Yeast mitochondria as a novel platform for in vivo antimycolate assays
Lett. Appl. Microbiol.
50
399-405
2010
Mycobacterium tuberculosis
Xia, Y.; Zhou, Y.; Carter, D.; McNeil, M.; Choi, W.; Halladay, J.; Berry, P.; Mao, W.; Hernandez, V.; O'Malley, T.; Korkegian, A.; Sunde, B.; Flint, L.; Woolhiser, L.; Scherman, M.; Gruppo, V.; Hastings, C.; Robertson, G.; Ioerger, T.; Sacchettini, J.
Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA
Life Sci. Alliance
1
e201800025
2018
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Marrakchi, H.; Laneelle, G.; Quemard, A.
InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II
Microbiology
146
289-296
2000
Mycobacterium tuberculosis, Mycobacterium tuberculosis mc(2)155
Lu, X.; You, Q.; Chen, Y.
Recent progress in the identification and development of InhA direct inhibitors of mycobacterium tuberculosis
Mini Rev. Med. Chem.
10
182-193
2010
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Molle, V.; Gulten, G.; Vilcheze, C.; Veyron-Churlet, R.; Zanella-Cleon, I.; Sacchettini, J.; Jacobs Jr, W.; Kremer, L.
Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis
Mol. Microbiol.
78
1591-1605
2010
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Kruh, N.; Rawat, R.; Ruzsicska, B.; Tonge, P.
Probing mechanisms of resistance to the tuberculosis drug isoniazid Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis
Protein Sci.
16
1617-1627
2007
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Jain, S.; Sharma, S.; Sen, D.; Pandya, S.
Enoyl-acyl carrier protein reductase (INHA) A remarkable target to exterminate tuberculosis
Anti-Infect. Agents
19
252-266
2021
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
-
Taira, J.; Umei, T.; Inoue, K.; Kitamura, M.; Berenger, F.; Sacchettini, J.C.; Sakamoto, H.; Aoki, S.
Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA) a structure-activity relationship study of KES4 assisted by in silico structure-based drug screening
J. Antibiot.
73
372-381
2020
Mycobacterium tuberculosis
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