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Information on EC 1.3.1.19 - cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
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EC Tree
1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenaseSpecify your search results
Word Map
- 1.3.1.19
- putida
- catechols
- dioxygenase
- dehydrogenases
-
plasmid-borne
- hydrocarbons
- cis-dihydrodiols
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2,3-dioxygenase
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nad+-dependent
- nadp+
- analysis
- synthesis
The enzyme appears in viruses and cellular organisms
Synonyms
cis-benzene dihydrodiol dehydrogenase, benzene dihydrodiol dehydrogenase, naphthalene cis-1,2-dihydrodiol dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
benzene dihydrodiol dehydrogenase
cis-benzene dihydrodiol dehydrogenase
cis-benzene glycol dehydrogenase
naphthalene cis-1,2-dihydrodiol dehydrogenase
NDDH
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
dehydrogenation
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oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
51923-03-6
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
cis-1,2-dihydrobenzene-3-chloro-(R,R)-1,2-diol + NAD+
3-chlorocatechol + NADH
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22% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
cis-1,2-dihydrobenzene-3-fluoro-(R,R)-1,2-diol + NAD+
3-fluorocatechol + NADH
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35% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
decane-1,2-diol + NAD+
dec-1-ene-1,2-diol + NADH
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8% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
nonane-1,2-diol + NAD+
non-1-ene-1,2-diol + NADH
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15% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
pentane-1,2-diol + NAD+
pent-1-ene-1,2-diol + NADH
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28% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
propane-1,2-diol + NAD+
prop-1-ene-1,2-diol + NADH
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36% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
trimethylbutane-1,2-diol + NAD+
trimethylbut-1-ene-1,2-diol + NADH
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21% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
5-methyl-hex-4-ene-1,2-diol + NAD+
5-methyl-hex-1,4-diene-1,2-diol + NADH + H+
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25% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
5-methyl-hex-4-ene-1,2-diol + NAD+
5-methyl-hex-1,4-diene-1,2-diol + NADH + H+
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25% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
5-methyl-hex-4-ene-1,2-diol + NAD+
5-methyl-hex-1,4-diene-1,2-diol + NADH + H+
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25% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
7-methyl-oct-6-ene-1,2-diol + NAD+
7-methyl-oct-1,6-diene-1,2-diol + NADH + H+
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13% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
7-methyl-oct-6-ene-1,2-diol + NAD+
7-methyl-oct-1,6-diene-1,2-diol + NADH + H+
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13% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
7-methyl-oct-6-ene-1,2-diol + NAD+
7-methyl-oct-1,6-diene-1,2-diol + NADH + H+
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13% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
butane-1,2-diol + NAD+
but-1-ene-1,2-diol + NADH
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29% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
butane-1,2-diol + NAD+
but-1-ene-1,2-diol + NADH
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29% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
butane-1,2-diol + NAD+
but-1-ene-1,2-diol + NADH
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29% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
cis-1,2-cyclohexanediol + NAD+
cyclohex-1-ene-1,2-diol + NADH
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?
cis-1,2-cyclohexanediol + NAD+
cyclohex-1-ene-1,2-diol + NADH
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?
cis-1,2-dihydrobenzene-1,2-diol + NAD+
catechol + NADH
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specific for the cis-form of benzene glycol and for NAD+ as a hydrogen acceptor
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?
cis-1,2-dihydrobenzene-1,2-diol + NAD+
catechol + NADH
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specific for the cis-form of benzene glycol and for NAD+ as a hydrogen acceptor
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?
cis-1,2-dihydrobenzene-1,2-diol + NAD+
catechol + NADH + H+
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?
cis-1,2-dihydrobenzene-1,2-diol + NAD+
catechol + NADH + H+
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?
cis-1,2-dihydrobenzene-3-bromo-(R,R)-1,2-diol + NAD+
3-bromocatechol + NADH
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7% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
cis-1,2-dihydrobenzene-3-bromo-(R,R)-1,2-diol + NAD+
3-bromocatechol + NADH
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7% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
cis-1,2-dihydrobenzene-3-bromo-(R,R)-1,2-diol + NAD+
3-bromocatechol + NADH
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7% of activity with cis-1,2-dihydrobenzene-1,2-diol
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?
additional information
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NDDH is inactive against cis-1,2-dihydronaphthalene and salicylaldehyde
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?
additional information
?
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NDDH is inactive against cis-1,2-dihydronaphthalene and salicylaldehyde
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
cis-1,2-dihydrobenzene-1,2-diol + NAD+
catechol + NADH + H+
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?
cis-1,2-dihydrobenzene-1,2-diol + NAD+
catechol + NADH + H+
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?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.2
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
metabolism
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the enzyme is involved in the metabolism and degradation of naphthalene
metabolism
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the enzyme is involved in the metabolism and degradation of naphthalene
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). D5PIB0_9MYCO
264
0
27438
TrEMBL
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E6TIQ4_MYCSR
Mycolicibacterium gilvum (strain DSM 45189 / LMG 24558 / Spyr1)
267
0
28239
TrEMBL
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
110000
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexamer
homohexamer
tetramer
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
loss of activity by ammonium sulfate precipitation and subsequent dialysis, restored by Fe2+
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
enzyme activity is retained during purification and storage in 100 mM Tris-HCl buffer, pH 7.2, containing 5% ethanol
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less stable at 4°C than at -20°C, loss of activity at 4°C gradually over a few days
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
native enzyme from strain 26K by anion exchange and hydrophobic interaction chromatography
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