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Reference on EC 1.3.1.3 - DELTA4-3-oxosteroid 5beta-reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Furuebisu, M.; Deguchi, S.; Okuda, K.
Identification of cortisone 5beta-reductase as DELTA4-3-ketosteroid 5beta-reductase
Biochim. Biophys. Acta
912
110-114
1987
Rattus norvegicus
Manually annotated by BRENDA team
Okuda, A.; Okuda, K.
Purification and characterization of DELTA 4-3-ketosteroid 5beta-reductase
J. Biol. Chem.
259
7519-7524
1984
Rattus norvegicus
Manually annotated by BRENDA team
Wilton, D.C.
Is a Schiff base involved in the mechanism of the DELTA4-3-oxo steroid 5alpha- or 5beta-reductases from mammalian liver?
Biochem. J.
155
487-491
1976
Rattus norvegicus
Manually annotated by BRENDA team
Collins, W.; Cameron, E.H.D.
Subcellular localization and properties of mouse adrenal C19-steroid 5beta-reductase
Biochem. J.
147
165-174
1975
Mus musculus
Manually annotated by BRENDA team
Forchielli, E.; Dorfmann, R.I.
Separation of DELTA4-5alpha- and DELTA4-5beta-hydrogenases from rat liver homogenates
J. Biol. Chem.
223
443-448
1956
Rattus norvegicus
Manually annotated by BRENDA team
Nduaguba, J.C.; Clark, A.F.
Steroid DELTA4-reductases of pig liver: partial purification of testosterone 5beta-reductase
Can. J. Biochem.
49
385-392
1971
Sus scrofa
Manually annotated by BRENDA team
Van Doorn, E.J.; Nduaguba, J.C.; Clark, A.F.
Studies on partially purified pig liver steroid DELTA4-5beta-reductase activity
Can. J. Biochem.
51
1661-1668
1973
Sus scrofa
Manually annotated by BRENDA team
Charbonneau, A.; The, V.L.
Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme
Biochim. Biophys. Acta
1517
228-235
2001
Homo sapiens
Manually annotated by BRENDA team
Dauphin-Villemant, C.; Blais, C.; Lafont, R.
Towards the elucidation of the ecdysteroid biosynthetic pathway
Ann. N. Y. Acad. Sci.
839
306-310
1998
Pancrustacea
-
Manually annotated by BRENDA team
Brown-Grant, K.; Forchielli, E.; Dorfman, R.I.
The DELTA4-hydrogenases of guinea pig adrenal gland
J. Biol. Chem.
235
1317-1320
1960
Cavia porcellus, Rattus norvegicus
Manually annotated by BRENDA team
Tomkins, G.M.
The enzymatic reduction of DELTA4-3-ketosteroids
J. Biol. Chem.
225
13-24
1957
Bos taurus, Cavia porcellus, Columba sp., Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Ozon, R.; Fouchet, C.; Perin, F.
Transformation of testosterone into 17beta-hydroxy-5beta-androstan-3-one by Rana esculenta skeletal muscle
Biochim. Biophys. Acta
348
425-437
1974
Pelophylax lessonae
Manually annotated by BRENDA team
Jez, J.M.; Penning, T.M.
Engineering steroid 5beta-reductase activity into rat liver 3alpha-hydroxysteroid dehydrogenase
Biochemistry
37
9695-9703
1998
Rattus norvegicus
Manually annotated by BRENDA team
Egerer-Sieber, C.; Herl, V.; Mller-Uri, F.; Kreis, W.; Muller, Y.A.
Crystallization and preliminary crystallographic analysis of selenomethionine-labelled progesterone 5beta-reductase from Digitalis lanata Ehrh
Acta Crystallogr. Sect. F
62
186-188
2006
Digitalis lanata
Manually annotated by BRENDA team
Gavidia, I.; Tarrio, R.; Rodriguez-Trelles, F.; Perez-Bermudez, P.; Ulrich Seitz, H.
Plant progesterone 5beta-reductase is not homologous to the animal enzyme. Molecular evolutionary characterization of P5betaR from Digitalis purpurea
Phytochemistry
68
853-864
2007
Digitalis purpurea
Manually annotated by BRENDA team
Herl, V.; Fischer, G.; Mller-Uri, F.; Kreis, W.
Molecular cloning and heterologous expression of progesterone 5beta-reductase from Digitalis lanata Ehrh.
Phytochemistry
67
225-231
2006
Digitalis lanata (Q6PQJ9), Digitalis lanata
Manually annotated by BRENDA team
Herl, V.; Fischer, G.; Btsch, R.; Mller-Uri, F.; Kreis, W.
Molecular cloning and expression of progesterone 5beta-reductase (5beta-POR) from Isoplexis canariensis
Planta Med.
72
1163-1165
2006
Digitalis canariensis (Q078S6), Digitalis canariensis
Manually annotated by BRENDA team
Faucher, F.; Cantin, L.; Luu-The, V.; Labrie, F.; Breton, R.
The crystal structure of human DELTA4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism
Biochemistry
47
8261-8270
2008
Homo sapiens (P51857), Homo sapiens
Manually annotated by BRENDA team
Di Costanzo, L.; Drury, J.E.; Penning, T.M.; Christianson, D.W.
Crystal structure of human liver DELTA4-3-ketosteroid 5beta-reductase (AKR1D1) and implications for substrate binding and catalysis
J. Biol. Chem.
283
16830-16839
2008
Homo sapiens
Manually annotated by BRENDA team
Di Costanzo, L.; Penning, T.M.; Christianson, D.W.
Aldo-keto reductases in which the conserved catalytic histidine is substituted
Chem. Biol. Interact.
178
127-133
2009
Digitalis lanata
Manually annotated by BRENDA team
Thorn, A.; Egerer-Sieber, C.; Jaeger, C.; Herl, V.; Mueller-Uri, F.; Kreis, W.; Muller, Y.
The crystal structure of progesterone 5beta-reductase from Digitalis lanata defines a novel class of short chain dehydrogenases/reductases
J. Biol. Chem.
283
17260-17269
2008
Digitalis lanata (Q6PQJ9), Digitalis lanata
Manually annotated by BRENDA team
Faucher, F.; Cantin, L.; Luu-The, V.; Labrie, F.; Breton, R.
Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition
Biochemistry
47
13537-13546
2008
Homo sapiens (P51857), Homo sapiens
Manually annotated by BRENDA team
Ueki, I.; Kimura, A.; Chen, H.L.; Yorifuji, T.; Mori, J.; Itoh, S.; Maruyama, K.; Ishige, T.; Takei, H.; Nittono, H.; Kurosawa, T.; Kage, M.; Matsuishi, T.
SRD5B1 gene analysis needed for the accurate diagnosis of primary 3-oxo-Delta4-steroid 5beta-reductase deficiency
J. Gastroenterol. Hepatol.
24
776-785
2009
Homo sapiens (P51857)
Manually annotated by BRENDA team
Di Costanzo, L.; Drury, J.E.; Christianson, D.W.; Penning, T.M.
Structure and catalytic mechanism of human steroid 5beta-reductase (AKR1D1)
Mol. Cell. Endocrinol.
301
191-198
2009
Homo sapiens (P51857), Homo sapiens
Manually annotated by BRENDA team
Palermo, M.; Marazzi, M.G.; Hughes, B.A.; Stewart, P.M.; Clayton, P.T.; Shackleton, C.H.
Human Delta4-3-oxosteroid 5beta-reductase (AKR1D1) deficiency and steroid metabolism
Steroids
73
417-423
2008
Homo sapiens (P51857), Homo sapiens
Manually annotated by BRENDA team
Mindnich, R.; Drury, J.E.; Penning, T.M.
The effect of disease associated point mutations on 5beta-reductase (AKR1D1) enzyme function
Chem. Biol. Interact.
191
250-254
2011
Homo sapiens
Manually annotated by BRENDA team
Drury, J.E.; Mindnich, R.; Penning, T.M.
Characterization of disease-related 5beta-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiency
J. Biol. Chem.
285
24529-24537
2010
Homo sapiens, Homo sapiens (P51857)
Manually annotated by BRENDA team
McNeilly, A.D.; Macfarlane, D.P.; OFlaherty, E.; Livingstone, D.E.; Mitic, T.; McConnell, K.M.; McKenzie, S.M.; Davies, E.; Reynolds, R.M.; Thiesson, H.C.; Skott, O.; Walker, B.R.; Andrew, R.
Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice
J. Hepatol.
52
705-711
2010
Rattus norvegicus
Manually annotated by BRENDA team
Bauer, P.; Rudolph, K.; Mueller-Uri, F.; Kreis, W.
Vein patterning 1-encoded progesterone 5beta-reductase: activity-guided improvement of catalytic efficiency
Phytochemistry
77
53-59
2012
Digitalis lanata, Arabidopsis thaliana (Q9STX2)
Manually annotated by BRENDA team
Chen, M.; Drury, J.E.; Penning, T.M.
Substrate specificity and inhibitor analyses of human steroid 5beta-reductase (AKR1D1)
Steroids
76
484-490
2011
Homo sapiens
Manually annotated by BRENDA team
Chen, M.; Wangtrakuldee, P.; Zang, T.; Duan, L.; Gathercole, L.L.; Tomlinson, J.W.; Penning, T.M.
Human and murine steroid 5beta-reductases (AKR1D1 and AKR1D4) insights into the role of the catalytic glutamic acid
Chem. Biol. Interact.
305
163-170
2019
Mus musculus (Q8VCX1), Mus musculus
Manually annotated by BRENDA team
Li, Y.; Pan, H.; Chang, Y.; Dong, N.; Zou, L.; Liang, P.; Tian, W.; Chang, Z.
Identification of key sites determining the cofactor specificity and improvement of catalytic activity of a steroid 5beta-reductase from Capsella rubella
Enzyme Microb. Technol.
134
109483
2020
Capsella rubella (R0F4W3)
Manually annotated by BRENDA team
Zhang, Y.; Li, X.; Xu, D.; Wu, M.; Dai, Y.; Xia, M.; Wang, D.
Cloning and characterization of steroid 5beta-reductase from the venom gland of Bufo bufo gargarizans
Int. J. Biol. Macromol.
175
67-78
2021
Bufo gargarizans
Manually annotated by BRENDA team
Appanna, N.; Gibson, H.; Gangitano, E.; Dempster, N.J.; Morris, K.; George, S.; Arvaniti, A.; Gathercole, L.L.; Keevil, B.; Penning, T.M.; Storbeck, K.H.; Tomlinson, J.W.; Nikolaou, N.
Differential activity and expression of human 5beta-reductase (AKR1D1) splice variants
J. Mol. Endocrinol.
66
181-194
2021
Homo sapiens (P51857), Homo sapiens
Manually annotated by BRENDA team
Valanejad, L.; Nadolny, C.; Shiffka, S.; Chen, Y.; You, S.; Deng, R.
Differential feedback regulation of Delta4-3-oxosteroid 5beta-reductase expression by bile acids
PLoS ONE
12
e0170960
2017
Homo sapiens (P51857), Homo sapiens, Mus musculus (Q8VCX1)
Manually annotated by BRENDA team