Reference on EC 1.3.1.72 - DELTA24-sterol reductase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bae, S.H.; Paik, Y.K.
Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol DELTA24-reductase
Biochem. J.
326
609-616
1997
Rattus norvegicus
Filipovic, I.; Buddecke, E.
Calmodulin antagonists suppress cholesterol synthesis by inhibiting sterol DELTA24 reductase
Lipids
22
261-265
1987
Homo sapiens, Rattus norvegicus
Short, J.D.; Guo, D.A.; Svoboda, J.A.; Nes, W.D.
Mechanistic and metabolic studies of sterol 24,25-double bond reduction in Manduca sexta
Arch. Insect Biochem. Physiol.
31
1-22
1996
Bombyx mori, Manduca sexta
-
Cho, S.Y.; Kim, J.H.; Paik, Y.K.
Cholesterol biosynthesis from lanosterol: differential inhibition of sterol DELTA8-isomerase and other lanosterol-converting enzymes by tamoxifen
Mol. Cells
8
233-239
1998
Rattus norvegicus
Waterham, H.R.; Koster, J.; Romeijn, G.J.; Hennekam, R.C.M.; Vreken, P.; Andersson, H.C.; FitzPatrick, D.R.; Kelley, R.I.; Wanders, R.J.A.
Mutations in the 3beta-hydroxysterol DELTA24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis
Am. J. Hum. Genet.
69
685-694
2001
Homo sapiens
Fernandez, C.; Suarez, Y.; Ferruelo, A.J.; Gomez-Coronado, D.; Lasuncion, M.A.
Inhibition of cholesterol biosynthesis by DELTA22-unsaturated phytosterols via competitive inhibition of sterol DELTA24-reductase in mammalian cells
Biochem. J.
366
109-119
2002
Homo sapiens, Rattus norvegicus
Tao, Y.; Zheng, J.; Xu, Z.; Zhang, X.; Zhang, K.; Wang, G.
Functional analysis of ZmDWF1, a maize homolog of the Arabidopsis brassinosteroids DWF1/DIM gene.
Plant Sci.
167
743-751
2004
Zea mays (Q5YFA2)
Mirza, R.; Hayasaka, S.; Takagishi, Y.; Kambe, F.; Ohmori, S.; Maki, K.; Yamamoto, M.; Murakami, K.; Kaji, T.; Zadworny, D.; Murata, Y.; Seo, H.
DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis
J. Invest. Dermatol.
126
638-647
2006
Mus musculus (Q8VCH6)
Giera, M.; Renard, D.; Ploessl, F.; Bracher, F.
Lathosterol side chain amidesa new class of human lathosterol oxidase inhibitors
Steroids
73
299-308
2008
Homo sapiens
Lu, X.; Kambe, F.; Cao, X.; Kozaki, Y.; Kaji, T.; Ishii, T.; Seo, H.
3beta-Hydroxysteroid-DELTA24 reductase is a hydrogen peroxide scavenger, protecting cells from oxidative stress-induced apoptosis
Endocrinology
149
3267-3273
2008
Mus musculus
Kuehnle, K.; Crameri, A.; Kaelin, R.E.; Luciani, P.; Benvenuti, S.; Peri, A.; Ratti, F.; Rodolfo, M.; Kulic, L.; Heppner, F.L.; Nitsch, R.M.; Mohajeri, M.H.
Prosurvival effect of DHCR24/seladin-1 in acute and chronic responses to oxidative stress
Mol. Cell. Biol.
28
539-550
2008
Homo sapiens
Pedretti, A.; Bocci, E.; Maggi, R.; Vistoli, G.
Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations
Steroids
73
708-719
2008
Homo sapiens (Q15392), Homo sapiens
Rodriguez-Acebes, S.; de la Cueva, P.; Fernandez-Hernando, C.; Ferruelo, A.J.; Lasuncion, M.A.; Rawson, R.B.; Martinez-Botas, J.; Gomez-Coronado, D.
Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-DELTA24-reductase-deficient cell line
Biochem. J.
420
305-315
2009
Mus musculus
Stevenson, J.; Brown, A.J.
How essential is cholesterol?
Biochem. J.
420
e1-e4
2009
Mus musculus
Nishimura, T.; Kohara, M.; Izumi, K.; Kasama, Y.; Hirata, Y.; Huang, Y.; Shuda, M.; Mukaidani, C.; Takano, T.; Tokunaga, Y.; Nuriya, H.; Satoh, M.; Saito, M.; Kai, C.; Tsukiyama-Kohara, K.
Hepatitis C virus impairs p53 via persistent overexpression of 3beta-hydroxysterol DELTA24-reductase
J. Biol. Chem.
284
36442-36452
2009
Homo sapiens
Zerenturk, E.J.; Kristiana, I.; Gill, S.; Brown, A.J.
The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)
Biochim. Biophys. Acta
1821
1269-1277
2012
Cricetulus griseus, Homo sapiens
Zerenturk, E.J.; Sharpe, L.J.; Brown, A.J.
Sterols regulate 3beta-hydroxysterol DELTA24-reductase (DHCR24) via dual sterol regulatory elements: cooperative induction of key enzymes in lipid synthesis by Sterol Regulatory Element Binding Proteins
Biochim. Biophys. Acta
1821
1350-1360
2012
Homo sapiens
Mirza, R.; Qiao, S.; Tateyama, K.; Miyamoto, T.; Xiuli, L.; Seo, H.
3beta-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species
J. Bone Miner. Metab.
30
144-153
2012
Mus musculus
Lu, X.; Li, Y.; Liu, J.; Cao, X.; Wang, X.; Wang, D.; Seo, H.; Gao, B.
The membrane topological analysis of 3beta-hydroxysteroid-DELTA24 reductase (DHCR24) on endoplasmic reticulum
J. Mol. Endocrinol.
48
1-9
2012
Homo sapiens
Yoshinari, K.; Ohno, H.; Benoki, S.; Yamazoe, Y.
Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase
Toxicol. Lett.
208
185-191
2012
Homo sapiens, Mus musculus
Zerenturk, E.J.; Sharpe, L.J.; Brown, A.J.
DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains implications for the activities of this multi-functional enzyme
Biosci. Rep.
34
e00098
2014
Homo sapiens (Q15392)
Wu, B.; Chen, K.; Shrestha, S.; Ong, K.; Barter, P.; Rye, K.
High-density lipoproteins inhibit vascular endothelial inflammation by increasing 3beta-hydroxysteroid-DELTA24 reductase expression and inducing heme oxygenase-1
Circ. Res.
112
278-288
2013
Homo sapiens (Q15392)
Tsukagoshi, Y.; Suzuki, H.; Seki, H.; Muranaka, T.; Ohyama, K.; Fujimoto, Y.
Ajuga DELTA24-sterol reductase catalyzes the direct reductive conversion of 24-methylenecholesterol to campesterol
J. Biol. Chem.
291
8189-8198
2016
Oryza sativa, Ajuga reptans (A0A0P0UTN5)
Luu, W.; Zerenturk, E.J.; Kristiana, I.; Bucknall, M.P.; Sharpe, L.J.; Brown, A.J.
Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis
J. Lipid Res.
55
410-420
2014
Homo sapiens (Q15392), Homo sapiens
Luu, W.; Hart-Smith, G.; Sharpe, L.J.; Brown, A.J.
The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally
J. Lipid Res.
56
888-897
2015
Homo sapiens (Q15392), Homo sapiens
Lu, X.; Jia, D.; Zhao, C.; Wang, W.; Liu, T.; Chen, S.; Quan, X.; Sun, D.; Gao, B.
Recombinant adenovirus-mediated overexpression of 3beta-hydroxysteroid-DELTA24 reductase
Neural Regen. Res.
9
504-512
2014
Homo sapiens (Q15392), Homo sapiens, Rattus norvegicus (Q5BQE6)
Saito, M.; Takano, T.; Nishimura, T.; Kohara, M.; Tsukiyama-Kohara, K.
3beta-hydroxysterol DELTA24-reductase on the surface of hepatitis C virus-related hepatocellular carcinoma cells can be a target for molecular targeting therapy
PLoS ONE
10
e0124197
2015
Homo sapiens (Q15392)
Silvestro, D.; Andersen, T.G.; Schaller, H.; Jensen, P.E.
Plant sterol metabolism. DELTA7-Sterol-C5-desaturase (STE1/DWARF7), DELTA5,7-sterol-DELTA7-reductase (DWARF5) and DELTA24-sterol-DELTA24-reductase (DIMINUTO/DWARF1) show multiple subcellular localizations in Arabidopsis thaliana (Heynh) L
PLoS ONE
8
e56429
2013
Arabidopsis thaliana (Q39085), Arabidopsis thaliana Col-0 (Q39085)
Lu, X.; Li, Y.; Wang, W.; Chen, S.; Liu, T.; Jia, D.; Quan, X.; Sun, D.; Chang, A.K.; Gao, B.
3 beta-hydroxysteroid-DELTA 24 reductase (DHCR24) protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum (ER) stress
PLoS ONE
9
e86753
2014
Homo sapiens (Q15392)
Zerenturk, E.J.; Sharpe, L.J.; Ikonen, E.; Brown, A.J.
Desmosterol and DHCR24 unexpected new directions for a terminal step in cholesterol synthesis
Prog. Lipid Res.
52
666-680
2013
Arabidopsis thaliana, Bombyx mori, Homo sapiens (Q15392), Homo sapiens
Kohlhaas, J.; Jaeger, M.; Lust, L.; De La Torre, C.; Hecker, M.; Korff, T.
Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression
Exp. Cell Res.
399
112446
2021
Homo sapiens
Tabrez, S.; Rahman, F.; Ali, R.; Akand, S.K.; Alaidarous, M.A.; Banawas, S.; Dukhyil, A.A.B.; Rub, A.
Hesperidin targets Leishmania donovani sterol C-24 reductase to fight against leishmaniasis
ACS Omega
6
8112-8118
2021
Leishmania donovani (E9BQ02), Leishmania donovani, Leishmania donovani BPK282A1 (E9BQ02)
Fujimori, H.; Zhou, Y.; Fukumura, K.; Matsumoto, S.; Tukamoto, Y.; Nagata, S.
Specific distribution of expression and enzymatic activity of cholesterol biosynthetic enzyme DHCR24 orthologs in the phytophagous insect
Biosci. Biotechnol. Biochem.
84
126-133
2020
Bombyx mori
Mueller, C.; Hemmers, S.; Bartl, N.; Plodek, A.; Koerner, A.; Mirakaj, V.; Giera, M.; Bracher, F.
New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase
Eur. J. Med. Chem.
140
305-320
2017
Homo sapiens
Wang, N.; Gong, Z.; Wang, J.; Xu, W.; Yang, Q.; Chen, S.
Characterization of Chinese tongue sole (Cynoglossus semilaevis) 24-dehydrocholesterol reductase Expression profile, epigenetic modification, and its knock-down effect
Gen. Comp. Endocrinol.
312
113870
2021
Cynoglossus semilaevis
Yavuz, U.; Alaylioglu, M.; Senguel, B.; Karras, S.N.; Gezen-Ak, D.; Dursun, E.
Protein disulfide isomerase A3 might be involved in the regulation of 24-dehydrocholesterol reductase via vitamin D equilibrium in primary cortical neurons
In Vitro Cell. Dev. Biol. Anim.
57
704-714
2021
Rattus norvegicus
Youn, J.H.; Kim, T.W.; Joo, S.H.; Son, S.H.; Roh, J.; Kim, S.; Kim, T.W.; Kim, S.K.
Function and molecular regulation of DWARF1 as a C-24 reductase in brassinosteroid biosynthesis in Arabidopsis
J. Exp. Bot.
69
1873-1886
2018
Arabidopsis thaliana
Koerner, A.; Zhou, E.; Mueller, C.; Mohammed, Y.; Herceg, S.; Bracher, F.; Rensen, P.C.N.; Wang, Y.; Mirakaj, V.; Giera, M.
Inhibition of DELTA24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution
Proc. Natl. Acad. Sci. USA
116
20623-20634
2019
Mus musculus
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