Any feedback?
Information on EC 1.3.1.78 - arogenate dehydrogenase (NADP+)
for references in articles please use BRENDA:EC1.3.1.78Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.3.1.78 arogenate dehydrogenase (NADP+)IUBMB Comments
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NADP+-dependent enzymes usually predominate in higher plants.The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly [2,3].
Specify your search results
Word Map
- 1.3.1.78
-
kinase-inactive
- prephenate
-
gadd45
-
malformation
-
annexin
-
ifngamma
-
neurulation
-
perinuclear
-
calcium-dependent
-
mekks
The enzyme appears in viruses and cellular organisms
Synonyms
tyra1, tyra2, tyraat1, tyrasy, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
TyrAa
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-arogenate + NADP+ = L-tyrosine + NADPH + CO2 + H+
-
-
-
-
L-arogenate + NADP+ = L-tyrosine + NADPH + CO2 + H+
mechanism is probably steady-state random order
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
L-arogenate:NADP+ oxidoreductase (decarboxylating)
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NADP+-dependent enzymes usually predominate in higher plants.The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly [2,3].
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
64295-75-6
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
prephenate + NADP+
3-(4-hydroxyphenyl)-2-oxopropanoate + CO2 + NADPH
-
-
-
-
?
L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
-
-
-
?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
-
exclusive metabolic route to tyrosine
-
?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
-
i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
-
?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
-
important enzyme in regulation of tyrosine biosynthesis
-
?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
-
i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
specific for, no activity with prephenate and NAD+
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
rapid equilibrium random mechanism in which two dead-end complexes, enzyme-NADPH-arogenate and enzyme-NADP+-tyrosine are formed
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
specific for, no activity with prephenate and NAD+
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
specific for, no activity with prephenate and NAD+
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
specific for, no activity with prephenate and NAD+
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
specific for, no activity with prephenate and NAD+
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
specific for, no activity with prephenate and NAD+
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
specific for, no activity with prephenate and NAD+
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
specific for, no activity with prephenate and NAD+
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
specific for, no activity with prephenate and NAD+
-
-
?
additional information
?
-
-
TyrAAT1 is four times more efficient in catalyzing arogenate dehydrogenase reaction than TyrAAT2. TyrAAT2 presents a weak prephenate dehydrogenase activity whereas Tyr-AAT1 does not
-
-
?
additional information
?
-
-
no activity with prephenate and NAD+
-
-
?
additional information
?
-
-
no activity with prephenate and NAD+
-
-
?
additional information
?
-
-
no activity with prephenate and NAD+
-
-
?
additional information
?
-
-
no activity with prephenate and NAD+
-
-
?
additional information
?
-
no activity with prephenate and NAD+
-
-
?
additional information
?
-
-
no activity with prephenate and NAD+
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-arogenate + NAD+
L-tyrosine + NADH + CO2
-
exclusive metabolic route to tyrosine
-
?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
-
i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
-
?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
-
important enzyme in regulation of tyrosine biosynthesis
-
?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
-
i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
enzyme of the arogenate pathway
-
-
?
L-arogenate + NADP+
L-tyrosine + NADPH + CO2
-
enzyme of the arogenate pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
almost completely insensitive to feedback inhibition by tyrosine. Phenylalanine and tryptophan show no effect at concentrations of up to 1 mM
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
84.2
<