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Information on EC 1.3.1.94 - polyprenol reductase

for references in articles please use BRENDA:EC1.3.1.94

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IUBMB Comments

The reaction occurs in the reverse direction with reduction of the terminal double bond next to the alcohol group. Isolated from human fetal brain tissue but present in all eukaryotes. In mammalian cells dolichols are predominantly 18-21 isoprene units in length.

The enzyme appears in viruses and cellular organisms

Synonyms
srd5a3, polyprenol reductase, steroid 5alpha-reductase type 3, dfg10, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH + H+
show the reaction diagram
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