Reference on EC 1.3.3.4 - protoporphyrinogen oxidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ferreira, G.C.; Dailey, H.A.
Reconstitution of the two terminal enzymes of the heme biosynthetic pathway into phospholipid vesicles
J. Biol. Chem.
262
4407-4412
1987
Mus musculus
Poulson, R.
The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX in mammalian mitochondria
J. Biol. Chem.
251
3730-3733
1976
Saccharomyces cerevisiae, Homo sapiens, Rattus norvegicus
Poulson, R.; Polglase, W.J.
The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX. Protoporphyrinogen oxidase activity in mitochondrial extracts of Saccharomyces cerevisiae
J. Biol. Chem.
250
1269-1274
1975
Saccharomyces cerevisiae
Camadro, J.M.; Urban-Grimal, D.; Labbe, P.
A new assay for protoporphyrinogen oxidase - evidence for a total deficiency in that activity in a heme-less mutant of Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
106
724-730
1982
Saccharomyces cerevisiae
Jones, C.; Jordan, P.M.; Akhtar, M.
Mechanism and stereochemistry of the porphobilinogen deaminase and protoporphyrinogen IX oxidase reactions: Stereospecific manipulation of hydrogen atoms at the for methylene bridges
J. Chem. Soc. Perkin Trans. I
1984
2625-2633
1984
Cereibacter sphaeroides
-
Deybach, J.C.; Da Silva, V.; Grandchamp, B.; Nordmann, Y.
The mitochondrial location of protoporphyrinogen oxidase
Eur. J. Biochem.
149
431-435
1985
Rattus norvegicus
Camadro, J.M.; Abraham, N.G.; Levere, R.D.
Kinetic properties of the membrane-bound human liver mitochondrial protoporphyrinogen oxidase
Arch. Biochem. Biophys.
242
206-212
1985
Homo sapiens
McColl, K.E.L.; Bond, F.M.; Thompson, G.G.; Moore, M.R.
Haem biosynthesis in the Gunn rat
Biochem. Soc. Trans.
14
921-922
1986
Rattus norvegicus
Klemm, D.J.; Barton, L.L.
Purification and properties of protoporphyrinogen oxidase from an anaerobic bacterium, Desulfovibrio gigas
J. Bacteriol.
169
5209-5215
1987
Megalodesulfovibrio gigas
Dailey, H.A.; Karr, S.W.
Purification and characterization of murine protoporphyrinogen oxidase
Biochemistry
26
2697-2701
1987
Mus musculus
Jacobs, J.M.; Jacobs, N.J.
Oxidation of protoporphyrinogen to protoporphyrin, a step in chlorophyll and haem biosynthesis. Purification and partial characterization of the enzyme from barley organelles
Biochem. J.
244
219-224
1987
Hordeum vulgare
Siepker, L.J.; Ford, M.; de Kock, R.; Kramer, S.
Purification of bovine protoporphyrinogen oxidase: immunological cross-reactivity and structural relationship to ferrochelatase
Biochim. Biophys. Acta
913
349-358
1987
Bos taurus
Li, F.; Lim, C.K.; Peters, T.J.
An HPLC assay for protoporphyrinogen oxidase activity in rat liver
Biochem. J.
243
863-866
1987
Rattus norvegicus
Ferreira, G.C.; Dailey, H.A.
Mouse protoporphyrinogen oxidase. Kinetic parameters and demonstration of inhibition by bilirubin
Biochem. J.
250
597-603
1988
Mus musculus
Ferreira, G.C.; Andrew, T.L.; Karr, S.W.; Dailey, H.A.
Organization of the terminal two enzymes of the heme biosynthetic pathway. Orientation of protoporphyrinogen oxidase and evidence for a membrane complex
J. Biol. Chem.
263
3835-3839
1988
Mus musculus
Witkowski, D.A.; Halling, B.P.
Inhibition of plant protoporphyrinogen oxidase by the herbicide acifluoren-methyl
Plant Physiol.
90
1239-1242
1989
Cucumis sativus
Matringe, M.; Camadro, J.M.; Labbe, P.; Scalla, R.
Protoporphyrinogen oxidase inhibition by three peroxidizing herbicides: oxadiazon, LS 82-556 and M&B 39279
FEBS Lett.
245
35-38
1989
Saccharomyces cerevisiae, Mus musculus, Solanum tuberosum, Zea mays
Jacobs, N.J.; Borotz, S.E.; Jacobs, J.M.
Characteristics of purified protoporphyrinogen oxidase from barley
Biochem. Biophys. Res. Commun.
161
790-796
1989
Hordeum vulgare
Matringe, M.; Camadro, J.M.; Labbe, P.; Scalla, R.
Protoporphyrinogen oxidase as a molecular target for diphenyl ether herbicides
Biochem. J.
260
231-235
1989
Mus musculus, Saccharomyces cerevisiae, Solanum tuberosum, Zea mays
Ramseier, T.M.; Kaluza, B.; Studer, D.; Gloudmans, T.; Bisseling, T.; Jordan, P.M.; Jones, R.M.; Zuber, M.; Hennecke, H.
Cloning of a DNA region from Bradyrhizobium japonicum encoding pleiotropic functions in heme metabolism and respiration
Arch. Microbiol.
151
203-212
1989
Bradyrhizobium japonicum
-
Camadro, J.M.; Thome, F.; Brouillet, N.; Labbe, P.
Purification and properties of protoporphyrinogen oxidase from the yeast Saccharomyces cerevisiae: mitochondrial location and evidence for a precursor form of the protein
J. Biol. Chem.
269
32085-32091
1994
Saccharomyces cerevisiae
Meissner, P.N.; Dailey, T.A.; Hift, R.J.; Ziman, M.; Corrigall, A.V.; Roberts, A.G.; Meissner, D.M.; Kirsch, R.E.; Dailey, H.A.
A R59W mutation in human protoporphyrinogen oxidase results in decreased enzyme activity and is prevalent in South Africans with variegate porphyria
Nature Genet.
13
95-97
1996
Homo sapiens
Birchfield, N.B.; Casida, J.E.
Protoporphyrinogen oxidase: high affinity tetrahydrophthalimide radioligand for the inhibitor/herbicide-binding site in mouse liver mitochondria
Chem. Res. Toxicol.
9
1135-1139
1996
Mus musculus
Dailey, T.A.; Dailey, H.A.
Human protoporphyrinogen oxidase: Expression, purification, and characterization of the cloned enzyme
Protein Sci.
5
98-105
1996
Homo sapiens
Dailey, H.A.; Dailey, T.A.
Protoporphyrinogen oxidase of Myxococcus xanthus. Expression, purification, and characterization of the cloned enzyme
J. Biol. Chem.
271
8714-8718
1996
Myxococcus xanthus
Camadro, J.M.; Labbe, P.
Cloning and characterization of the yeast HEM14 gene coding for protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides
J. Biol. Chem.
271
9120-9128
1996
Saccharomyces cerevisiae
Dailey, H.A.; Dailey, T.A.
Characteristics of human protoporphyrinogen oxidase in controls and variegate porphyrias
Cell. Mol. Biol.
43
67-73
1997
Homo sapiens
Arnould, S.; Berthon, J.L.; Hubert, C.; Dias, M.; Cibert, C.; Mornet, R.; Camadro, J.M.
Kinetics of protoporphyrinogen oxidase inhibition by diphenyleneiodonium derivatives
Biochemistry
36
10178-10184
1997
Saccharomyces cerevisiae
Lermontova, I.; Kruse, E.; Mock, H.P.; Grimm, B.
Cloning and characterization of a plastidal and a mitochondrial isoform of tobacco protoporphyrinogen IX oxidase
Proc. Natl. Acad. Sci. USA
94
8895-8900
1997
Nicotiana tabacum
Randolph-Anderson, B.L.; Sato, R.; Johnson, A.M.; Harris, E.H.; Hauser, C.R.; Oeda, K.; Ishige, F.; Nishio, S.; Gillham, N.W.; Boynton, J.E.
Isolation and characterization of a mutant protoporphyrinogen oxidase gene from Chlamydomonas reinhardtii conferring resistance to porphyric herbicides
Plant Mol. Biol.
38
839-859
1998
Chlamydomonas reinhardtii
Corrigall, A.V.; Siziba, K.B.; Maneli, M.H.; Shephard, E.G.; Ziman, M.; Dailey, T.A.; Dailey, H.A.; Kirsch, R.E.; Meissner, P.N.
Purification of and kinetic studies on a cloned protoporphyrinogen oxidase from the aerobic bacterium Bacillus subtilis
Arch. Biochem. Biophys.
358
251-256
1998
Bacillus subtilis
Birchfield, N.B.; Latli, B.; Casida, J.E.
Human protoporphyrinogen oxidase: Relation between the herbicide binding site and the flavin cofactor
Biochemistry
37
6905-6910
1998
Homo sapiens
Le Guen, L.; Santos, R.; Camadro, J.M.
Functional analysis of the hemK gene product involvement in protoporphyrinogen oxidase activity in yeast
FEMS Microbiol. Lett.
173
175-182
1999
Saccharomyces cerevisiae
Che, F.S.; Watanabe, N.; Iwano, M.; Inokuchi, H.; Takayama, S.; Yoshida, S.; Isogai, A.
Molecular characterization and subcellular localization of protoporphyrinogen oxidase in spinach chloroplasts
Plant Physiol.
124
59-70
2000
Spinacia oleracea
Watanabe, N.; Che, F.S.; Terashima, K.; Takayama, S.; Yoshida, S.; Isogai, A.
Purification and properties of protoporphyrinogen oxidase from spinach chloroplasts
Plant Cell Physiol.
41
889-892
2000
Spinacia oleracea
Jeong, E.; Han, O.
Purification and characterization of Bacillus subtilis protoporphyrinogen oxidase and pre-equilibrium behavior during oxidation of protoporphyrinogen IX
J. Biochem. Mol. Biol.
34
39-42
2001
Bacillus subtilis
-
Dailey, T.A.; McManus, J.F.; Dailey, H.A.
Characterization of the mouse protoporphyrinogen oxidase gene
Cell. Mol. Biol.
48
61-69
2002
Mus musculus
de Marco, A.; Volrath, S.; Law, M.; Fonne-Pfister, R.
Correct identification of the chloroplastic protoporphyrinogen IX oxidase N-terminus places the biochemical data in frame
Biochem. Biophys. Res. Commun.
309
873-878
2003
Zea mays
Maneli, M.H.; Corrigall, A.V.; Klump, H.H.; Davids, L.M.; Kirsch, R.E.; Meissner, P.N.
Kinetic and physical characterisation of recombinant wild-type and mutant human protoporphyrinogen oxidases
Biochim. Biophys. Acta
1650
10-21
2003
Homo sapiens
Jeong, E.; Houn, T.; Kuk, Y.; Kim, E.S.; Chandru, H.K.; Baik, M.; Back, K.; Guh, J.O.; Han, O.
A point mutation of valine-311 to methionine in Bacillus subtilis protoporphyrinogen oxidase does not greatly increase resistance to the diphenyl ether herbicide oxyfluorfen
Bioorg. Chem.
31
389-397
2003
Bacillus subtilis (P32397), Bacillus subtilis
Watanabe, N.; Takayama, S.; Yoshida, S.; Isogai, A.; Che, F.S.
Resistance to protoporphyrinogen oxidase-inhibiting compound S23142 from overproduction of mitochondrial protoporphyrinogen oxidase by gene amplification in photomixotrophic tobacco cells
Biosci. Biotechnol. Biochem.
66
1799-1805
2002
Nicotiana tabacum
Morgan, R.R.; da, S.V.; Puy, H.; Deybach, J.C.; Elder, G.H.
Functional studies of mutations in the human protoporphyrinogen oxidase gene in variegate porphyria
Cell. Mol. Biol.
48
79-82
2002
Homo sapiens
Koch, M.; Breithaupt, C.; Kiefersauer, R.; Freigang, J.; Huber, R.; Messerschmidt, A.
Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis
EMBO J.
23
1720-1728
2004
Nicotiana tabacum (O24164), Nicotiana tabacum
von und zu Fraunberg, M.; Timonen, K.; Mustajoki, P.; Kauppinen, R.
Clinical and biochemical characteristics and genotype-phenotype correlation in Finnish variegate porphyria patients
Eur. J. Hum. Genet.
10
649-657
2002
Homo sapiens (P50336), Homo sapiens
D'Amato, M.; Bonuglia, M.; Barile, S.; Griso, D.; Macri, A.; Biolcati, G.
Genetic analysis of variegate porphyria (VP) in Italy: identification of six novel mutations in the protoporphyrinogen oxidase (PPOX) gene
Hum. Mutat.
21
448
2003
Homo sapiens
Jung, S.; Chung, J.S.; Chon, S.U.; Kuk, Y.I.; Lee, H.J.; Guh, J.O.; Back, K.
Expression of recombinant protoporphyrinogen oxidase influences growth and morphological characteristics in transgenic rice
Plant Growth Regul.
42
283-288
2004
Bacillus subtilis
-
van Lis, R.; Atteia, A.; Nogaj, L.A.; Beale, S.I.
Subcellular localization and light-regulated expression of protoporphyrinogen IX oxidase and ferrochelatase in Chlamydomonas reinhardtii
Plant Physiol.
139
1946-1958
2005
Chlamydomonas reinhardtii (Q9ZTA7), Chlamydomonas reinhardtii
Shepherd, M.; Dailey, H.A.
A continuous fluorimetric assay for protoporphyrinogen oxidase by monitoring porphyrin accumulation
Anal. Biochem.
344
115-121
2005
Aquifex aeolicus, Homo sapiens, Mus musculus, Myxococcus xanthus
Downs, C.; Downs, A.
Preliminary examination of short-term cellular toxicological responses of the coral Madracis mirabilis to acute Irgarol 1051 exposure
Arch. Environ. Contam. Toxicol.
52
47-57
2007
Madracis myriaster
Heinemann, I.U.; Diekmann, N.; Masoumi, A.; Koch, M.; Messerschmidt, A.; Jahn, M.; Jahn, D.
Functional definition of the tobacco protoporphyrinogen IX oxidase substrate binding site
Biochem. J.
402
575-580
2007
Nicotiana tabacum
Kuk, Y.I.; Lee, H.J.; Chung, J.S.; Kim, K.M.; Lee, S.B.; Ha, S.B.; Back, K.; Guh, J.O.
Expression of a Bacillus subtilis protoporphyrinogen oxidase gene in rice plants reduces sensitivity to peroxidizing herbicides
Biol. Plant.
49
577-583
2005
Bacillus subtilis, Oryza sativa
-
Davids, L.M.; Corrigall, A.V.; Meissner, P.N.
Mitochondrial targeting of human protoporphyrinogen oxidase
Cell Biol. Int.
30
416-426
2006
Homo sapiens
Corradi, H.R.; Corrigall, A.V.; Boix, E.; Mohan, C.G.; Sturrock, E.D.; Meissner, P.N.; Acharya, K.R.
Crystal structure of protoporphyrinogen oxidase from Myxococcus xanthus and its complex with the inhibitor acifluorfen
J. Biol. Chem.
281
38625-38633
2006
Myxococcus xanthus
Yang, K.; Jung, S.; Lee, Y.; Back, K.
Modifying Myxococcus xanthus protoporphyrinogen oxidase to plant codon usage and high level of oxyfluorfen resistance in transgenic rice
Pestic. Biochem. Physiol.
86
186-194
2006
synthetic construct (AY916795), Myxococcus xanthus (P56601)
-
Jung, S.; Lee, Y.; Back, K.
A tobacco plastidal transit sequence cannot override the dual targeting capacity of Myxococcus xanthus protoporphyrinogen oxidase in transgenic rice
Pestic. Biochem. Physiol.
86
49-56
2006
Myxococcus xanthus
-
Daugrois, J.H.; Hoy, J.W.; Griffin, J.L.
Protoporphyrinogen oxidase inhibitor herbicide effects on pythium root rot of sugarcane, Pythium species, and the soil microbial community
Phytopathology
95
220-226
2005
Globisporangium ultimum, Saccharum officinarum, Pythium aphanidermatum, Pythium arrhenomanes
Lermontova, I.; Grimm, B.
Reduced activity of plastid protoporphyrinogen oxidase causes attenuated photodynamic damage during high-light compared to low-light exposure
Plant J.
48
499-510
2006
Nicotiana tabacum (O24163), Nicotiana tabacum
Jung, S.; Back, K.
Herbicidal and antioxidant responses of transgenic rice overexpressing Myxococcus xanthus protoporphyrinogen oxidase
Plant Physiol. Biochem.
43
423-430
2005
Myxococcus xanthus, Oryza sativa
Hanaoka, R.; Dawid, I.B.; Kawahara, A.
Cloning and expression of zebrafish genes encoding the heme synthesis enzymes uroporphyrinogen III synthase (UROS) and protoporphyrinogen oxidase (PPO)
DNA Seq.
18
54-60
2007
Danio rerio (Q1ET38), Danio rerio
de Vooght, K.M.; van Wijk, R.; van Solinge, W.W.
GATA-1 binding sites in exon 1 direct erythroid-specific transcription of PPOX
Gene
409
83-91
2008
Homo sapiens (P50336), Homo sapiens
Luo, Y.P.; Jiang, L.L.; Wang, G.D.; Chen, Q.; Yang, G.F.
Syntheses and herbicidal activities of novel triazolinone derivatives
J. Agric. Food Chem.
56
2118-2124
2008
Amaranthus retroflexus, Brassica juncea, Chenopodium album, Digitaria sanguinalis, Echinochloa crus-galli, Setaria viridis
Lee, K.; Yang, K.; Kang, K.; Kang, S.; Lee, N.; Back, K.
Use of Myxococcus xanthus protoporphyrinogen oxidase as a selectable marker for transformation of rice
Pestic. Biochem. Physiol.
88
31-35
2007
Myxococcus xanthus
-
Jung, H.I.; Kuk, Y.I.; Back, K.; Burgos, N.R.
Resistance pattern and antioxidant enzyme profiles of protoporphyrinogen oxidase (PROTOX) inhibitor-resistant transgenic rice
Pestic. Biochem. Physiol.
91
53-65
2008
Myxococcus xanthus
-
Jung, S.; Lee, H.J.; Lee, Y.; Kang, K.; Kim, Y.S.; Grimm, B.; Back, K.
Toxic tetrapyrrole accumulation in protoporphyrinogen IX oxidase-overexpressing transgenic rice plants
Plant Mol. Biol.
67
535-546
2008
Homo sapiens
Lee, R.M.; Hager, A.G.; Tranel, P.J.
Prevalence of a novel resistance mechanism to PPO-inhibiting herbicides in waterhemp (Amaranthus tuberculatus)
Weed Sci.
56
371-375
2008
Amaranthus tuberculatus
Sun, L.; Wen, X.; Tan, Y.; Li, H.; Yang, X.; Zhao, Y.; Wang, B.; Cao, Q.; Niu, C.; Xi, Z.
Site-directed mutagenesis and computational study of the Y366 active site in Bacillus subtilis protoporphyrinogen oxidase
Amino Acids
37
523-530
2009
Bacillus subtilis (P32397), Bacillus subtilis
Tan, Y.; Sun, L.; Xi, Z.; Yang, G.F.; Jiang, D.Q.; Yan, X.P.; Yang, X.; Li, H.Y.
A capillary electrophoresis assay for recombinant Bacillus subtilis protoporphyrinogen oxidase
Anal. Biochem.
383
200-204
2008
Bacillus subtilis
Zhang, L.; Hao, G.F.; Tan, Y.; Xi, Z.; Huang, M.Z.; Yang, G.F.
Bioactive conformation analysis of cyclic imides as protoporphyrinogen oxidase inhibitor by combining DFT calculations, QSAR and molecular dynamic simulations
Bioorg. Med. Chem.
17
4935-4942
2009
Homo sapiens
Corrigall, A.V.; Campbell, J.A.; Siziba, K.; Kirsch, R.E.; Meissner, P.N.
The expression of protoporphyrinogen oxidase in human tissues
Cell. Mol. Biol.
55
89-95
2009
Homo sapiens (P50336), Homo sapiens
Van Tuyll Van Serooskerke, A.M.; Schneider-Yin, X.; Schimmel, R.J.; Bladergroen, R.S.; Poblete-Gutierrez, P.; Barman, J.; van Geel, M.; Frank, J.; Minder, E.I.
Identification of a recurrent mutation in the protoporphyrinogen oxidase gene in Swiss patients with variegate porphyria: clinical and genetic implications
Cell. Mol. Biol.
55
96-101
2009
Homo sapiens
Li, H.B.; Zhu, Y.Q.; Song, X.W.; Hu, F.Z.; Liu, B.; Li, Y.H.; Niu, Z.X.; Liu, P.; Wang, Z.H.; Song, H.B.; Zou, X.M.; Yang, H.Z.
Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives
J. Agric. Food Chem.
56
9535-9542
2008
Zea mays
Lei, B.; Li, J.; Lu, J.; Du, J.; Liu, H.; Yao, X.
Rational prediction of the herbicidal activities of novel protoporphyrinogen oxidase inhibitors by quantitative structure-activity relationship model based on docking-guided active conformation
J. Agric. Food Chem.
57
9593-9598
2009
Brassica rapa subsp. oleifera
Roy, K.; Paul, S.
Docking and 3D QSAR studies of protoporphyrinogen oxidase inhibitor 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives
J. Mol. Model.
16
137-153
2010
Myxococcus xanthus (P56601)
Masoumi, A.; Heinemann, I.U.; Rohde, M.; Koch, M.; Jahn, M.; Jahn, D.
Complex formation between protoporphyrinogen IX oxidase and ferrochelatase during haem biosynthesis in Thermosynechococcus elongatus
Microbiology
154
3707-3714
2008
Thermosynechococcus vestitus
Shepherd, M.; Dailey, H.A.
Peroxidase activity of cytochrome C facilitates the protoporphyrinogen oxidase reaction
Cell. Mol. Biol.
55
6-14
2009
Drosophila melanogaster
Dayan, F.E.; Daga, P.R.; Duke, S.O.; Lee, R.M.; Tranel, P.J.; Doerksen, R.J.
Biochemical and structural consequences of a glycine deletion in the alpha-8 helix of protoporphyrinogen oxidase
Biochim. Biophys. Acta
1804
1548-1556
2010
Amaranthus tuberculatus (Q0NZW5), Amaranthus tuberculatus (Q0NZW6), Amaranthus tuberculatus
Zhang, L.; Tan, Y.; Wang, N.X.; Wu, Q.Y.; Xi, Z.; Yang, G.F.
Design, syntheses and 3D-QSAR studies of novel N-phenyl pyrrolidin-2-ones and N-phenyl-1H-pyrrol-2-ones as protoporphyrinogen oxidase inhibitors
Bioorg. Med. Chem.
18
7948-7956
2010
Amaranthus retroflexus, Brassica juncea, Chenopodium album, Digitaria sanguinalis, Echinochloa crus-galli, Homo sapiens, Setaria viridis, Eclipta prostrata
Jiang, L.L.; Tan, Y.; Zhu, X.L.; Wang, Z.F.; Zuo, Y.; Chen, Q.; Xi, Z.; Yang, G.F.
Design, synthesis, and 3D-QSAR analysis of novel 1,3,4-oxadiazol-2(3H)-ones as protoporphyrinogen oxidase inhibitors
J. Agric. Food Chem.
58
2643-2651
2010
Homo sapiens
Qin, X.; Sun, L.; Wen, X.; Yang, X.; Tan, Y.; Jin, H.; Cao, Q.; Zhou, W.; Xi, Z.; Shen, Y.
Structural insight into unique properties of protoporphyrinogen oxidase from Bacillus subtilis
J. Struct. Biol.
170
76-82
2010
Bacillus subtilis (P32397), Bacillus subtilis
Kato, K.; Tanaka, R.; Sano, S.; Tanaka, A.; Hosaka, H.
Identification of a gene essential for protoporphyrinogen IX oxidase activity in the cyanobacterium Synechocystis sp. PCC6803
Proc. Natl. Acad. Sci. USA
107
16649-16654
2010
Synechocystis sp. (P72793), Synechocystis sp.
Zuo, Y.; Yang, S.G.; Jiang, L.L.; Hao, G.F.; Wang, Z.F.; Wu, Q.Y.; Xi, Z.; Yang, G.F.
Quantitative structure-activity relationships of 1,3,4-thiadiazol-2(3H)-ones and 1,3,4-oxadiazol-2(3H)-ones as human protoporphyrinogen oxidase inhibitors
Bioorg. Med. Chem.
20
296-304
2012
Homo sapiens
Yang, Z.; Sheng-Gang, Y.; Yan-Ping, L.; Ying, T.; Ge-Fei, H.; Qiong-You, W.; Zhen, X.; Guang-Fu, Y.
Design and synthesis of 1-(benzothiazol-5-yl)-1H-1,2,4-triazol-5-ones as protoporphyrinogen oxidase inhibitors
Bioorg. Med. Chem.
21
3245-3255
2013
Nicotiana tabacum
Jiang, L.L.; Zuo, Y.; Wang, Z.F.; Tan, Y.; Wu, Q.Y.; Xi, Z.; Yang, G.F.
Design and syntheses of novel N-(benzothiazol-5-yl)-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione and N-(benzothiazol-5-yl)isoindoline-1,3-dione as potent protoporphyrinogen oxidase inhibitors
J. Agric. Food Chem.
59
6172-6179
2011
Homo sapiens
Engstroem, P.; Nguyen, B.D.; Normark, J.; Nilsson, I.; Bastidas, R.J.; Gylfe, A.; Elofsson, M.; Fields, K.A.; Valdivia, R.H.; Wolf-Watz, H.; Bergstroem, S.
Mutations in hemG mediate resistance to Salicylidene acylhydrazides: A novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity
J. Bacteriol.
195
4221-4230
2013
Chlamydia trachomatis, Chlamydia trachomatis 434/Bu
Dailey, H.A.; Septer, A.N.; Daugherty, L.; Thames, D.; Gerdes, S.; Stabb, E.V.; Dunn, A.K.; Dailey, T.A.; Phillips, J.D.
The Escherichia coli protein YfeX functions as a porphyrinogen oxidase, not a heme dechelatase
mBio
2
e00248
2011
Escherichia coli
Hao, G.F.; Tan, Y.; Yang, S.G.; Wang, Z.F.; Zhan, C.G.; Xi, Z.; Yang, G.F.
Computational and experimental insights into the mechanism of substrate recognition and feedback inhibition of protoporphyrinogen oxidase
PLoS ONE
8
e69198
2013
Homo sapiens, Nicotiana tabacum
Hansson, M.; Gustafsson, M.C.; Kannangara, C.G.; Hederstedt, L.
Isolated Bacillus subtilis HemY has coproporphyrinogen III to coproporphyrin III oxidase activity
Biochim. Biophys. Acta
1340
97-104
1997
Bacillus subtilis (P32397), Bacillus subtilis 168 (P32397)
Boateng, M.; Corrigall, A.; Sturrock, E.; Meissner, P.
Characterisation of the flavin adenine dinucleotide binding region of Myxococcus xanthus protoporphyrinogen oxidase
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Homo sapiens (P50336), Homo sapiens
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Understanding resistance mechanism of protoporphyrinogen oxidase-inhibiting herbicides insights from computational mutation scanning and site-directed mutagenesis
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Homo sapiens (P50336)
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Nicotiana tabacum (O24164), Nicotiana tabacum
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Molecular simulations bring new insights into protoporphyrinogen IX oxidase/protoporphyrinogen IX interaction modes
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Nicotiana tabacum (O24164), Nicotiana tabacum
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Amaranthus retroflexus, Chenopodium album, Commelina communis, Digitaria sanguinalis, Echinochloa crus-galli, Portulaca oleracea, Solanum nigrum, Zinnia elegans, Abutilon theophrasti, Persicaria lapathifolia
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Nicotiana tabacum (O24164), Homo sapiens (P50336)
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Tetrapyrrole biosynthetic enzyme protoporphyrinogen IX oxidase 1 is required for plastid RNA editing
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Arabidopsis thaliana (P55826), Arabidopsis thaliana
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The hydrogen bonding network involved Arg59 in human protoporphyrinogen IX oxidase is essential for enzyme activity
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Homo sapiens
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Nicotiana tabacum
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Conformation of the intermediates in the reaction catalyzed by protoporphyrinogen oxidase An in silico analysis
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Homo sapiens
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Design, synthesis, and molecular mechanism studies of N-phenylisoxazoline-thiadiazolo[3,4-a]pyridazine hybrids as protoporphyrinogen IX oxidase inhibitors
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Nicotiana tabacum
Wang, D.W.; Liang, L.; Xue, Z.Y.; Yu, S.Y.; Zhang, R.B.; Wang, X.; Xu, H.; Wen, X.; Xi, Z.
Discovery of N-phenylaminomethylthioacetylpyrimidine-2,4-diones as protoporphyrinogen IX oxidase inhibitors through a reaction intermediate derivation approach
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Nicotiana tabacum
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Design and synthesis of N-phenyl phthalimides as potent protoporphyrinogen oxidase inhibitors
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Digitaria sanguinalis
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Escherichia coli
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Abutilon theophrasti
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Characterization of HemY-type protoporphyrinogen IX oxidase genes from cyanobacteria and their functioning in transgenic Arabidopsis
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Arabidopsis thaliana (P55826), Arabidopsis thaliana
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PPO-inhibiting herbicides and structurally relevant Schiff bases Evaluation of inhibitory activities against human protoporphyrinogen oxidase
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2021
Homo sapiens
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