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Disease on EC 1.3.5.1 - succinate dehydrogenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Habitual
Infertility and recurrent miscarriage with complex II deficiency-dependent mitochondrial oxidative stress in animal models.
Achlorhydria
Gastric acid secretion, serum gastrin and parietal cell histology in hyperthyroidism.
Acidosis
A morphological, enzyme-cytochemical, and physiological study of the blood-gonad barrier in the hermaphroditic snail Lymnaea stagnalis.
The use of transgenic and mutant mice to study oxygen free radical metabolism.
Acidosis, Lactic
A novel de novo dominant mutation in
Cavitating leukoencephalopathy with multiple mitochondrial dysfunction syndrome and NFU1 mutations.
Expression of oxidative phosphorylation genes in muscle cell cultures from patients with mitochondrial myopathies.
Hereditary myopathy with lactic acidosis, succinate dehydrogenase and aconitase deficiency in northern Sweden: a genealogical study.
Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain.
Predominant cerebellar volume loss as a neuroradiologic feature of pediatric respiratory chain defects.
Respiratory complex II defect in siblings associated with a symptomatic secondary block in fatty acid oxidation.
Strongly succinate dehydrogenase-reactive blood vessels in muscles from patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.
aconitate hydratase deficiency
Hereditary myopathy with lactic acidosis, succinate dehydrogenase and aconitase deficiency in northern Sweden: a genealogical study.
Mitochondrial myopathy with succinate dehydrogenase and aconitase deficiency. Abnormalities of several iron-sulfur proteins.
Acquired Immunodeficiency Syndrome
The AIDS dementia complex: II. Neuropathology.
Acromegaly
Genetics of gigantism and acromegaly.
Acute Kidney Injury
Acute renal failure potentiates brain energy dysfunction elicited by methylmalonic acid.
Acute Lung Injury
Activation of hypoxia-inducible factor -1? via succinate dehydrogenase pathway during acute lung injury induced by trauma/hemorrhagic shock.
Targeting alveolar-specific succinate dehydrogenase A attenuates pulmonary inflammation during acute lung injury.
Acute Radiation Syndrome
[Interpretation of histochemical changes of succinate dehydrogenase activity in liver parenchyma during the monitoring of the clinical course of the acute radiation syndrome: study of sublethally whole-body irradiated rats]
Addison Disease
Autoantibodies to the flavoprotein subunit of succinate dehydrogenase: analysis of specificity in autoimmune thyroid disease.
Adenocarcinoma
Alternative efficacy-predicting markers for paclitaxel instead of CHFR in non-small cell lung cancer.
An evaluation of carcinogenicity predictors from short-term and sub chronic repeat-dose studies of agrochemicals in rats: Opportunities to refine and reduce animal use.
Antitumor chemosensitivity differs between clinical sarcoma and adenocarcinoma tissues.
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
Hematoporphyrin derivative-induced photosensitivity of mitochondrial succinate dehydrogenase and selected cytosolic enzymes of R3230AC mammary adenocarcinomas of rats.
Lung adenocarcinoma is more sensitive than gastric adenocarcinoma to anticancer drugs in vitro.
Molecular Factors Associated with Pemetrexed Sensitivity According to Histological Type in Non-small Cell Lung Cancer.
Relationship between tumor histopathology and in vitro sensitivity to antitumor drugs in gastric cancer.
Skeletal muscle metabolism in mice bearing adenocarcinoma. I. Histochemical alterations in glycogenolytic, glycolytic, lipolytic and oxidative metabolism.
Synergism of cytotoxicity between cis-diaminedichloro-platinum-(ii) and cis-diamine(1,1-cyclobutanedicarboxylate)-platinum-(ii).
[Oxidoreductase activity in the cells of stomach cancer]
Adenocarcinoma of Lung
Lung adenocarcinoma is more sensitive than gastric adenocarcinoma to anticancer drugs in vitro.
Adenocarcinoma, Bronchiolo-Alveolar
[Enzyme cytochemistry and morphometric study of the effects of macrophages on A549 pulmonary alveolar cell carcinoma cell line]
Adenoma
A compound adrenal medullary tumor (pheochromocytoma and ganglioneuroma) and a cortical adenoma in the ipsilateral adrenal gland. A case report with enzyme histochemical and immunohistochemical studies.
An evaluation of carcinogenicity predictors from short-term and sub chronic repeat-dose studies of agrochemicals in rats: Opportunities to refine and reduce animal use.
Histochemical investigation of aldosterone-secreting cells adenoma of the adrenal cortex.
Adenoma, Liver Cell
Histogenesis of dieldrin and DDT-induced hepatocellular carcinoma in Balb/c mice.
Adenoma, Oxyphilic
Mitochondrial complex I is deficient in renal oncocytomas.
Renal Oncocytoma With Both Lymphovascular Invasion and Prominent Intracytoplasmic Vacuole-Like Spaces: A Case Report and Review of the Literature.
Adrenocortical Carcinoma
Adrenocortical carcinoma and succinate dehydrogenase gene mutations.
Li-Fraumeni Syndrome and p53 in 2015: Celebrating their Silver Anniversary.
AIDS Dementia Complex
The AIDS dementia complex: II. Neuropathology.
Alzheimer Disease
A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.
Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease.
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Anaphylaxis
[Succinate dehydrogenase activity of the liver during sensitization and in anaphylactic shock]
Anemia
[Activity of kidney tissue enzymes in phenylhydrazine anemia and post-transfusion polycythemia]
Anemia, Aplastic
An enzymologic study on bone marrow cells in patients with aplastic anemia treated by supplementing the kidney and removing blood stasis.
Anetoderma
Anetoderma Associated With a Succinate Dehydrogenase Gene Mutation: A Potential Link Between Anetoderma and Citric Acid Cycle Mutations.
Apnea
Heterogeneity of FHF1 related phenotype: Novel case with early onset severe attacks of apnea, partial mitochondrial respiratory chain complex II deficiency, neonatal onset seizures without neurodegeneration.
Arteriosclerosis
[Studies on arteriosclerosis and endangitis obliterans. VI. The behavior of succinic dehydrogenase in skeletal musculature in peripheral vascular disorders.]
Arthritis
Bone Density of the Femur and Fiber Cross-Sectional Area and Oxidative Enzyme Activity of the Tibialis Anterior Muscle in Type II Collagen-Induced Arthritic Mice.
Oxidative state and oxidative metabolism of the heart from rats with adjuvant-induced arthritis.
Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1?/VEGF axis.
Arthritis, Experimental
Histochemical changes of substance P, FRAP, serotonin and succinic dehydrogenase in the spinal cord of rats with adjuvant arthritis.
Arthritis, Rheumatoid
Association between the functional MHC2TA -168 A/G polymorphism and susceptibility to rheumatoid arthritis: a meta-analysis.
Rheumatoid arthritis: identifying and characterising polymorphisms using rat models.
Succinate/NLRP3 Inflammasome Induces Synovial Fibroblast Activation: Therapeutical Effects of Clematichinenoside AR on Arthritis.
Asthenozoospermia
Altered Expression of Succinic Dehydrogenase in Asthenozoospermia Infertile Male.
Astrocytoma
Alterations of oxidative phosphorylation complexes in astrocytomas.
Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.
Ataxia
Deficiency of complex II of the mitochondrial respiratory chain in late-onset optic atrophy and ataxia.
Late-onset optic atrophy, ataxia, and myopathy associated with a mutation of a complex II gene.
Atherosclerosis
Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100-Reactive CD4+ T-Regulatory Cells.
Succinic dehydrogenase activity of the myocardium in experimental atherosclerosis.
Barth Syndrome
Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome.
Identification of the human mitochondrial linoleoyl-coenzyme a monolysocardiolipin acyltransferase (MLCL AT-1).
Berylliosis
Potential binding modes of beryllium with the class II major histocompatibility complex HLA-DP: a combined theoretical and structural database study.
beta-ala-his dipeptidase deficiency
Impairment of electron transfer chain induced by acute carnosine administration in skeletal muscle of young rats.
Biliary Atresia
Mitochondrial dysfunction in liver failure requiring transplantation.
Birt-Hogg-Dube Syndrome
Morphological clues to the appropriate recognition of hereditary renal neoplasms.
Birth Injuries
[Activity of the enzymes glutamate and succinate dehydrogenase in the blood serum of newborns with intracranial birth injuries and asphyxia]
Bradycardia
[The succinic dehydrogenase activity of the heart and skeletal muscle of the pigeon with bradycardia produced by complete inanition or by orizanin-induced malnutrition.]
Brain Concussion
[Changes in the activities of oxidoreductases, content of malondialdehyde and medium weight molecules in the blood of patients with craniocerebral injuries of different severity]
Brain Diseases
Dopamine toxicity following long term exposure to low doses of 3-nitropropionic acid (3-NPA) in rats.
Expression of oxidative phosphorylation genes in muscle cell cultures from patients with mitochondrial myopathies.
Loss-of-function mutations in ISCA2 disrupt 4Fe-4S cluster machinery and cause a fatal leukodystrophy with hyperglycinemia and mtDNA depletion.
Multiple defects of the respiratory chain including complex II in a family with myopathy and encephalopathy.
Strongly succinate dehydrogenase-reactive blood vessels in muscles from patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.
Tricarboxylic acid cycle dysfunction as a cause of human diseases and tumor formation.
Two compound frame-shift mutations in succinate dehydrogenase gene of a Chinese boy with encephalopathy.
Brain Edema
A two-hour window for hypothermic modulation of early events that impact delayed opening of the rat blood-brain barrier after ischemia.
Brain damage related to hemorrhagic transformation following cerebral ischemia and the role of K ATP channels.
Brain Injuries
Activity of succinate dehydrogenase in the neocortex and hippocampus of Mongolian gerbils with ischemic and reperfusion brain injury.
Chemical preconditioning effect of 3-nitropropionic acid in anesthetized rat heart.
Effects of immune reaction in rats after acute carbon monoxide poisoning.
Brain Injuries, Traumatic
Changes in local cerebral blood flow, glucose utilization, and mitochondrial function following traumatic brain injury in rats.
Changes in rat cerebral mitochondrial succinate dehydrogenase activity after brain trauma.
Brain Ischemia
Biomechanical characteristics of brain edema: the difference between vasogenic-type and cytotoxic-type edema.
Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology.
Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate.
Malonate-induced generation of reactive oxygen species in rat striatum depends on dopamine release but not on NMDA receptor activation.
Respiratory chain inhibition induces tolerance to focal cerebral ischemia.
[Metabolic effects of mexidol in complex treatment of chronic brain ischemia]
Brain Neoplasms
[Succinate dehydrogenase and cytochrome oxidase activity in homogenates and mitochondrial fractions of brain tumors and non-neoplastic brain tissue]
Breast Neoplasms
A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II.
An "in vitro" method for the prediction of hormone dependency of human breast tumours by succinic dehydrogenase activity.
Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells.
Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC.
Modulating mammary tumor growth, metastasis and immunosuppression by siRNA-induced MIF reduction in tumor microenvironment.
No evidence for promoter region methylation of the succinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer.
Relationship of mitochondrial function and cellular adenosine triphosphate levels to pMC540 and merodantoin cytotoxicity in MCF-7 human breast cancer cells.
Succinate dehydrogenase expression in breast cancer.
Taurine Regulates Mitochondrial Function During 7,12-Dimethyl Benz[a]anthracene Induced Experimental Mammary Carcinogenesis.
The assembly factor SDHAF2 is dispensable for flavination of the catalytic subunit of mitochondrial complex II in breast cancer cells.
Transketolase regulates the metabolic switch to control breast cancer cell metastasis via the alpha-ketoglutarate signaling pathway.
[Antitumor activity of UFT and docetaxel on human breast carcinoma xenografts]
Carcinogenesis
A Histochemical Study of the Early Stages of Carcinogenesis in Rat Liver: Localization of Fluorescent Carcinogen and Changes in Succinic Dehydrogenase Activity.
A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis.
Alterations of respiratory chain complexes in sporadic pheochromocytoma.
Basic fibroblast growth factor and fibroblastic growth factor receptor-1 may contribute to head and neck paraganglioma development by an autocrine or paracrine mechanism.
Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells.
Central role of mitochondria in metabolic regulation of liver pathophysiology.
Contribution of the FAD and quinone binding sites to the production of reactive oxygen species from Ascaris suum mitochondrial complex II.
Familial wild-type gastrointestinal stromal tumour in association with germline truncating variants in both SDHA and PALB2.
Genetically-defined metabolic reprogramming in cancer.
Inflammation Associated Pancreatic Tumorigenesis: Upregulation of Succinate Dehydrogenase (Subunit B) Reduces Cell Growth of Pancreatic Ductal Epithelial Cells.
K40E: a novel succinate dehydrogenase (SDH)B mutation causing familial phaeochromocytoma and paraganglioma.
Landscape of the mitochondrial Hsp90 metabolome in tumours.
Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma.
Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.
Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma.
Metabolic changes in cancer: beyond the Warburg effect.
Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma.
Molecular pathogenesis of tumorigenesis caused by succinate dehydrogenase defect.
New insights into the genetics of familial chromaffin cell tumors.
Nucleolar succinate dehydrogenase & glucose-6-phosphatase activities during hepatocellular carcinogenesis in thioacetamide fed rat.
Pheochromocytoma and paraganglioma.
Respiratory chain complex II as general sensor for apoptosis.
Sh3glb1/Bif-1 and mitophagy: Acquisition of apoptosis resistance during Myc-driven lymphomagenesis.
Somatic and germline mutations in the pathogenesis of pituitary adenomas.
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.
Succinate dehydrogenase deficiency in a PDGFRA mutated GIST.
Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis.
Succinic dehydrogenase activity in D.M.B.A. induced experimental oral carcinogenesis in hamster cheek pouch.
Succinic dehydrogenase and cytochrome oxidase in epidermal carcinogenesis induced by methylcholanthrene in mice.
Targeted therapy in SDH-deficient GIST.
TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State.
The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency.
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway.
The role of complex II in disease.
The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.
Tissue dilution artefact; a re-interpretation of variations in levels of succinic dehydrogenase during chemical carcinogenesis.
Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations.
Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency.
Upregulation of SDHA inhibited proliferation, migration, and invasion of clear cell renal cell carcinoma cells via inactivation of the Wnt/?-catenin pathway.
Upregulation of ZNF148 in SDHB-deficient gastrointestinal stromal tumor potentiates Forkhead box M1-mediated transcription and promotes tumor cell invasion.
Yeast model for evaluating the pathogenic significance of SDHB, SDHC and SDHD mutations in PHEO-PGL syndrome.
[Enzymatic and immunologic activity of lymphocytes during chemical carcinogenesis]
[The state of the mitochondrial energy-supplying system of blood leukocytes in the dynamics of guerin's carcinoma growth under the low-level irradiation conditions.]
Carcinoma
A biochemical evaluation of oral squamous cell carcinoma growth by measurement of specific activity of succinate dehydrogenase in the subrenal capsule assay.
A case of Carney triad complicated by renal cell carcinoma and a germline SDHA pathogenic variant.
A conditional mouse model of complex II deficiency manifesting as Leigh-like syndrome.
A distinctive, low-grade oncocytic fumarate hydratase-deficient renal cell carcinoma, morphologically reminiscent of succinate dehydrogenase-deficient renal cell carcinoma.
A Novel SDHA-deficient Renal Cell Carcinoma Revealed by Comprehensive Genomic Profiling.
A report of succinate dehydrogenase B deficiency associated with metastatic papillary renal cell carcinoma: successful treatment with the multi-targeted tyrosine kinase inhibitor sunitinib.
A study of some mitochondrial and peroxisomal enzymes in human colonic adenocarcinoma.
Aberrant Splicing of SDHC in Families With Unexplained Succinate Dehydrogenase-Deficient Paragangliomas.
Advances in Renal Neoplasia: Recommendations From the 2012 International Society of Urological Pathology Consensus Conference.
Alternative efficacy-predicting markers for paclitaxel instead of CHFR in non-small cell lung cancer.
Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness.
Calculating the optimal surveillance for head and neck paraganglioma in SDHB-mutation carriers.
Central role of mitochondria in metabolic regulation of liver pathophysiology.
Changes in succinic dehydrogenase of the human stomach in patients with peptic ulcer or carcinoma. A histochemical study.
Chemosensitivity and DNA ploidy in head and neck squamous cell carcinomas.
Chemosensitivity test for carcinoma of digestive organs.
Clinical response and tissue effects of etretinate treatment of patients with solar keratoses and basal cell carcinoma.
Clinicopathologic features of succinate dehydrogenase deficiencient renal cell carcinoma.
Clinicopathological Characterization of Renal Cell Carcinoma in Young Adults: a contemporary update and review of literature.
Comparison of enzyme phenotypes in human bladder tumours and experimentally induced hyperplastic and neoplastic lesions of the rat urinary bladder. A combined histochemical and immunohistochemical approach.
Contemporary update on pathology-related issues of adult renal neoplasms.
Correlation between hyperthermoradiosensitivity and clinical effect in carcinoma of the esophagus.
Cytochemical studies of respiratory enzymes in carcinoma of the cervix uteri after irradiation by radium and cobalt 60.
Defects of the respiratory chain in the normal human liver and in cirrhosis during aging.
Enhancement of pulmonary tumour seeding by human coagulation factors II, IX, X--an investigation into the possible mechanisms involved.
Enzymatic responses of transplanted tumour cells towards estrogen, progesterone and testosterone.
Epigenetically modified pancreatic carcinoma PANC-1 cells can act as cancer vaccine to enhance antitumor immune response in mice.
Estrogens in carcinoma of the prostate. Effects on enzymes and polypeptide hormones.
Expression of glutathione S-transferase-pi and sensitivity of human gastric cancer cells to cisplatin.
Familial pheochromocytoma and renal cell carcinoma syndrome: TMEM127 as a novel candidate gene for the association.
Flow-cytometric determination of dehydrogenase activities in primary human gastrointestinal tumor cell lines.
Hereditary syndromes with associated renal neoplasia: a practical guide to histologic recognition in renal tumor resection specimens.
Histochemical localization of succinic dehydrogenase and endogenous reductase activity in squamous cell carcinoma of the cervix.
Histogenesis of dieldrin and DDT-induced hepatocellular carcinoma in Balb/c mice.
Histologic differentiation and chemosensitivity of human head and neck squamous cell carcinomas.
Incidence of succinate dehydrogenase and fumarate hydratase-deficient renal cell carcinoma based on immunohistochemical screening with SDHA/SDHB and FH/2SC.
Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas.
Intragenic mutations in thyroid cancer.
Mapping of Succinate Dehydrogenase Losses in 2258 Epithelial Neoplasms.
Morphological clues to the appropriate recognition of hereditary renal neoplasms.
Multifocal Renal Cell Carcinomas With Somatic IDH2 Mutation: Report of a Previously Undescribed Neoplasm.
Mutation analysis of HIF-prolylhydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.
Nucleolar succinic dehydrogenase in mouse mammary carcinoma cells.
Positive/retained SDHB immunostaining in renal cell carcinomas associated to germline SDHB-deficiency: case report.
Protein bound sulfhydryl and disulfide groups and succinic dehydrogenase activity in basal cell carcinoma of the skin.
Re-evaluation of 33 "Unclassified" Eosinophilic Renal Cell Carcinomas in Young Patients.
Renal carcinoma associated with a novel succinate dehydrogenase A mutation: a case report and review of literature of a rare subtype of renal carcinoma.
Renal cell carcinoma with TFE3 translocation and succinate dehydrogenase B mutation.
Renal Oncocytoma With Both Lymphovascular Invasion and Prominent Intracytoplasmic Vacuole-Like Spaces: A Case Report and Review of the Literature.
Review of succinate dehydrogenase-deficient renal cell carcinoma with focus on clinical and pathobiological aspects.
SDH-deficient renal cell carcinoma - clinical, pathologic and genetic correlates: a case report.
SDH-deficient renal cell carcinoma associated with biallelic mutation in succinate dehydrogenase A: comprehensive genetic profiling and its relation to therapy response.
SDH-deficient renal cell carcinoma: a clinicopathological analysis highlighting the role of genetic counselling.
SDHC epi-mutation testing in gastrointestinal stromal tumours and related tumours in clinical practice.
Sharing the initial experience of pan-cancer panel analysis in high-risk renal cell carcinoma in the Korean population.
Single nucleotide variants of succinate dehydrogenase A gene in renal cell carcinoma.
Structural and functional consequences of succinate dehydrogenase subunit B mutations.
Succinate dehydrogenase B-deficient renal cell carcinoma: A case report with novel germline mutation.
Succinate dehydrogenase B: a new prognostic biomarker in clear cell renal cell carcinoma.
Succinate dehydrogenase in dividing cells of human ovarian carcinoma in vitro.
Succinate Dehydrogenase-Deficient Renal Cancer Featuring Fructose-1,6-Biphosphatase Loss, Pyruvate Kinase M2 Overexpression, and SWI/SNF Chromatin Remodeling Complex Aberrations: A Rare Case Report.
Succinate Dehydrogenase-Deficient Renal Cell Carcinoma.
Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma.
Succinic acid dehydrogenase activity of Walker rat carcinoma 256 when utilizing riboflavin homologs.
Succinic dehydrogenase activity, protein bound sulfhydryl and disulfide groups in squamous cell carcinoma of the skin.
The Impact Of Succinate Dehydrogenase Gene (SDH) Mutations In Renal Cell Carcinoma (RCC): A Systematic Review.
The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.
The phenotype of SDHB germline mutation carriers: a nationwide study.
The role of complex II in disease.
Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations.
Translating in vivo metabolomic analysis of succinate dehydrogenase deficient tumours into clinical utility.
Urological cancer related to familial syndromes.
Utility of the succinate: Fumarate ratio for assessing SDH dysfunction in different tumor types.
[Activity of succinate dehydrogenase in ascites cells of Ehrlich carcinoma infected by herpesvirus]
[Effects of ginseng volatile oil on cytochemical components of SGC-823 gastric carcinoma in cell culture]
[Enzyme cytochemistry and morphometric study of the effects of macrophages on A549 pulmonary alveolar cell carcinoma cell line]
[Flow cytometric DNA analysis and chemosensitivity in squamous cell carcinoma of the head and neck]
[Glucose-6-phosphate dehydrogenase and succinate dehydrogenase in metastatic cells of Lewis lung carcinoma]
[Histochemical research on localization of distribution of succinic dehydrogenase activity in Paget's disease, basaloma and spinous cell carcinoma.]
[Hyperthermo-chemo-radiotherapy of patients with carcinoma of the esophagus and prediction of the clinical remedial value using the in vitro succinate dehydrogenase inhibition test]
[Succinic dehydrogenase activity in several cases of cervical carcinoma.]
[The cytochemical observation of inosine effect on glucose metabolism of BGC-823 human gastric carcinoma cell line]
[The significance of determining the peripheral blood succinate dehydrogenase in the lymphocytes and large granule-containing lymphocytes in diseases of the hepatobiliary system]
[The state of the mitochondrial energy-supplying system of blood leukocytes in the dynamics of guerin's carcinoma growth under the low-level irradiation conditions.]
[Ultracytochemical study of oxidoreductases in the parietal cells of the gastric mucosa in gastric cancer]
[Vancouver classification of renal tumors : Recommendations of the 2012 consensus conference of the International Society of Urological Pathology (ISUP).]
Carcinoma, Basal Cell
Clinical response and tissue effects of etretinate treatment of patients with solar keratoses and basal cell carcinoma.
Protein bound sulfhydryl and disulfide groups and succinic dehydrogenase activity in basal cell carcinoma of the skin.
Carcinoma, Ehrlich Tumor
Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria.
Comparison of Ehrlich ascites tumour and mouse liver cells by analytical subcellular fractionation combined with a sensitive computational method for data analysis.
Enzyme activities of six different dehydrogenases in Ehrlich ascites cells measured by flow cytometry.
[Fluorescent formazans in flow cytometry. Studies of their oxygen sensitivity]
Carcinoma, Hepatocellular
4'-O-tetrahydropyranyladriamycin has greater antineoplastic activity than adriamycin in various human tumours in vitro.
Abnormal membrane phospholipid content in subcellular fractions from the Morris 7777 hepatoma.
Characteristics of mitochondria isolated by rate zonal centrifugation from normal liver and Novikoff hepatomas.
Chemopreventive efficacy of selenium against N-nitrosodiethylamine-induced hepatoma in albino rats.
Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect.
Defects of the respiratory chain in the normal human liver and in cirrhosis during aging.
Ecotoxicological evaluation of diethanolamine using a battery of microbiotests.
Histochemical demonstration of succinic dehydrogenase in rat hepatoma.
Human hepatocellular carcinoma sensitivity to antitumor drugs assayed using the succinate dehydrogenase inhibition test.
Intracellular distribution of enzymes; the distribution of succinic dehydrogenase, cytochrome oxidase, adenosinetriphosphatase, and phosphorus compounds in normal rat liver and in rat hepatomas.
Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma.
Modulation of cell proliferation in rat liver cell cultures by new calix[4]arenes.
Respiratory complex II in mitochondrial dysfunction-mediated cytotoxicity: Insight from cadmium.
S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase.
Sensitivity to six antitumor drugs differs between primary and metastatic liver cancers.
Thioacetamide-induced hepatocarcinoma in rat.
Why to compare absolute numbers of mitochondria.
[Cytochemical study of cells of primary and disseminated ascite Yoshida tumor cells]
[QUANTITATIVE HISTOCHEMICAL DETERMINATION OF SUCCINIC DEHYDROGENASE ACTIVITY AND TRANSPLANTATED AAF-INDUCED HEPATOMAS IN THE RAT.]
[The sensitivity of 1,000 human tumors to antitumor drugs using the succinate dehydrogenase inhibition (SDI) test]
Carcinoma, Large Cell
Alternative efficacy-predicting markers for paclitaxel instead of CHFR in non-small cell lung cancer.
Carcinoma, Lewis Lung
[Glucose-6-phosphate dehydrogenase and succinate dehydrogenase in metastatic cells of Lewis lung carcinoma]
Carcinoma, Medullary
Intragenic mutations in thyroid cancer.
Carcinoma, Papillary
An unusual succinate dehydrogenase gene mutation C in a case of laryngeal paraganglioma.
Carcinoma, Renal Cell
A case of Carney triad complicated by renal cell carcinoma and a germline SDHA pathogenic variant.
A conditional mouse model of complex II deficiency manifesting as Leigh-like syndrome.
A Novel SDHA-deficient Renal Cell Carcinoma Revealed by Comprehensive Genomic Profiling.
A report of succinate dehydrogenase B deficiency associated with metastatic papillary renal cell carcinoma: successful treatment with the multi-targeted tyrosine kinase inhibitor sunitinib.
Aberrant Splicing of SDHC in Families With Unexplained Succinate Dehydrogenase-Deficient Paragangliomas.
Calculating the optimal surveillance for head and neck paraganglioma in SDHB-mutation carriers.
Clinical and morphologic review of 60 hereditary renal tumors from 30 hereditary renal cell carcinoma syndrome patients: lessons from a contemporary single institution series.
Clinicopathologic features of succinate dehydrogenase deficiencient renal cell carcinoma.
Clinicopathological Characterization of Renal Cell Carcinoma in Young Adults: a contemporary update and review of literature.
Contemporary update on pathology-related issues of adult renal neoplasms.
Familial pheochromocytoma and renal cell carcinoma syndrome: TMEM127 as a novel candidate gene for the association.
Hand-Assisted Laparoscopic Partial Nephrectomy for Large Renal Carcinoma with Succinate Dehydrogenase Deficiency.
Hereditary syndromes with associated renal neoplasia: a practical guide to histologic recognition in renal tumor resection specimens.
Incidence of succinate dehydrogenase and fumarate hydratase-deficient renal cell carcinoma based on immunohistochemical screening with SDHA/SDHB and FH/2SC.
Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability.
Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair.
Mapping of Succinate Dehydrogenase Losses in 2258 Epithelial Neoplasms.
Morphological clues to the appropriate recognition of hereditary renal neoplasms.
Multifocal Renal Cell Carcinomas With Somatic IDH2 Mutation: Report of a Previously Undescribed Neoplasm.
Mutation analysis of HIF-prolylhydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.
Positive/retained SDHB immunostaining in renal cell carcinomas associated to germline SDHB-deficiency: case report.
Re-evaluation of 33 "Unclassified" Eosinophilic Renal Cell Carcinomas in Young Patients.
Renal carcinoma associated with a novel succinate dehydrogenase A mutation: a case report and review of literature of a rare subtype of renal carcinoma.
Renal carcinoma associated with succinate dehydrogenase B mutation: a new and unique subtype of renal carcinoma.
Renal carcinoma with giant mitochondria associated with germ-line mutation and somatic loss of the succinate dehydrogenase B gene.
Renal cell carcinoma with TFE3 translocation and succinate dehydrogenase B mutation.
Renal Oncocytoma With Both Lymphovascular Invasion and Prominent Intracytoplasmic Vacuole-Like Spaces: A Case Report and Review of the Literature.
Review of succinate dehydrogenase-deficient renal cell carcinoma with focus on clinical and pathobiological aspects.
SDH-deficient renal cell carcinoma - clinical, pathologic and genetic correlates: a case report.
SDH-deficient renal cell carcinoma associated with biallelic mutation in succinate dehydrogenase A: comprehensive genetic profiling and its relation to therapy response.
SDH-deficient renal cell carcinoma: a clinicopathological analysis highlighting the role of genetic counselling.
SDHC epi-mutation testing in gastrointestinal stromal tumours and related tumours in clinical practice.
Signalling pathways in succinate dehydrogenase B-associated renal carcinoma.
Single nucleotide variants of succinate dehydrogenase A gene in renal cell carcinoma.
Structural and functional consequences of succinate dehydrogenase subunit B mutations.
Succinate Dehydrogenase (SDH) D Subunit (SDHD) Inactivation in a Growth-Hormone-Producing Pituitary Tumor: A New Association for SDH?
Succinate Dehydrogenase (SDH)-deficient Renal Carcinoma: A Morphologically Distinct Entity: A Clinicopathologic Series of 36 Tumors From 27 Patients.
Succinate dehydrogenase B-deficient renal cell carcinoma: A case report with novel germline mutation.
Succinate dehydrogenase B: a new prognostic biomarker in clear cell renal cell carcinoma.
Succinate dehydrogenase deficiency is rare in pituitary adenomas.
Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) - a review.
Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer.
Succinate Dehydrogenase-Deficient Renal Cancer Featuring Fructose-1,6-Biphosphatase Loss, Pyruvate Kinase M2 Overexpression, and SWI/SNF Chromatin Remodeling Complex Aberrations: A Rare Case Report.
Succinate Dehydrogenase-Deficient Renal Cell Carcinoma.
Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma.
The Impact Of Succinate Dehydrogenase Gene (SDH) Mutations In Renal Cell Carcinoma (RCC): A Systematic Review.
The phenotype of SDHB germline mutation carriers: a nationwide study.
The role of complex II in disease.
Translating in vivo metabolomic analysis of succinate dehydrogenase deficient tumours into clinical utility.
Urological cancer related to familial syndromes.
Utility of the succinate: Fumarate ratio for assessing SDH dysfunction in different tumor types.
Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?
Carcinoma, Squamous Cell
Alternative efficacy-predicting markers for paclitaxel instead of CHFR in non-small cell lung cancer.
Chemosensitivity and DNA ploidy in head and neck squamous cell carcinomas.
Cytochemical studies of respiratory enzymes in carcinoma of the cervix uteri after irradiation by radium and cobalt 60.
Histochemical localization of succinic dehydrogenase and endogenous reductase activity in squamous cell carcinoma of the cervix.
Histologic differentiation and chemosensitivity of human head and neck squamous cell carcinomas.
Succinic dehydrogenase activity, protein bound sulfhydryl and disulfide groups in squamous cell carcinoma of the skin.
[Flow cytometric DNA analysis and chemosensitivity in squamous cell carcinoma of the head and neck]
Carcinoma, Transitional Cell
Comparison of enzyme phenotypes in human bladder tumours and experimentally induced hyperplastic and neoplastic lesions of the rat urinary bladder. A combined histochemical and immunohistochemical approach.
Carcinosarcoma
Chronobiological analysis of peripheral lymphocyte dehydrogenase activities in rats with Walker 256 carcinosarcoma.
[A chronobiological analysis of the lymphocyte dehydrogenase activity in the peripheral blood of rats with Walker 256 carcinosarcoma]
[Succinic dehydrogenase in the liver, spleen and kidneys in Walker's carcinosarcoma in rats.]
Cardiomegaly
SUCCINIC DEHYDROGENASE DEFICIENCY IN IDIOPATHIC CARDIOMEGALY.
Cardiomyopathies
A recessive homozygous p.Asp92Gly SDHD mutation causes prenatal cardiomyopathy and a severe mitochondrial complex II deficiency.
Consolidating biallelic SDHD variants as a cause of mitochondrial complex II deficiency.
Familial neonatal isolated cardiomyopathy caused by a mutation in the flavoprotein subunit of succinate dehydrogenase.
Mitochondrial myopathy, cardiomyopathy, and pontine signal changes in an adult patient with isolated complex II deficiency.
Regional metastatic paraganglioma of the bladder: a rare cause of myocardial infarction, reversible cardiomyopathy and an intracardiac thrombus.
Succinate dehydrogenase deficiency associated with dilated cardiomyopathy and ventricular noncompaction.
Succinate dehydrogenase deficiency.
Succinate Dehydrogenase Deficiency: A Treatable Neurometabolic Disorder.
The role of complex II in disease.
Cardiomyopathy, Dilated
Succinate dehydrogenase deficiency associated with dilated cardiomyopathy and ventricular noncompaction.
The use of transgenic and mutant mice to study oxygen free radical metabolism.
Cardiomyopathy, Hypertrophic
Hypertrophic cardiomyopathy with mitochondrial myopathy. A new phenotype of complex II defect.
OXPHOS defects and mitochondrial DNA mutations in cardiomyopathy.
Cardiotoxicity
Ethanol toxicity in primary cultures of rat myocardial cells.
Histochemical alterations of acute and chronic doxorubicin cardiotoxicity.
Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice.
Carney Complex
Genetics of gigantism and acromegaly.
Pituitary gigantism: update on molecular biology and management.
Carotid Body Tumor
Carotid body tumors in humans caused by a mutation in the gene for succinate dehydrogenase D (SDHD).
Left Atrial and Carotid Body Paraganglioma.
Paraganglioma of the carotid body and intrapericardium.
Paraganglioma of the Carotid Body: Treatment Strategy and SDH-gene Mutations.
Recurrent familial malignant carotid body tumour presenting with lymph node metastasis: case report, and review of diagnosis and management of familial carotid body tumours.
[Endocrine surgery for neck paraganglioma : Operation, radiation therapy or wait and scan?]
Celiac Disease
HLA-DQ typing in the diagnosis of celiac disease.
Cerebral Infarction
Brain damage related to hemorrhagic transformation following cerebral ischemia and the role of K ATP channels.
Cerebral Palsy
Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy.
Chagas Disease
[Interatomic distances in succinate dehydrogenase inhibitors and substrate. Contribution to the drug therapy of Chagas' disease]
Chemical and Drug Induced Liver Injury
[NADH:ubiquinone reductase and succinate dehydrogenase activity in the liver of rats with acetaminophen-induced toxic hepatitis on the background of alimentary protein deficiency].
Cholera
[Energy allowance for antibody formation in rabbits immunized with cholera vaccine and by exposure to tetracyclines]
Cholestasis
Metabolic changes in rat brain histaminergic neurons during subhepatic cholestasis.
[Morpho-functional changes in the liver and the possibility of their correction in the offspring of rats with cholestasis].
[Succinate dehydrogenase activity in hepatocyte mitochondria in experimental cholestasis]
[Ultrastructural characteristics and succinate dehydrogenase activity of the hepatocyte mitochondria in cholestasis]
Cholesteatoma
Histochemical studies of cholesteatoma.
Chondroma
A bittersweet symphony.
IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas.
[Hereditary and non-hereditary syndromic gastointestinal stromal tumours].
Chondrosarcoma
IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas.
Chorea
Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic treated rats.
Coinfection
[Effect of a mixed E. coli O-111 (RNA-azopositive and RNA-azonegative strains) and Coxsackie B3 viral infection on oxygen demand and on the succinate dehydrogenase activity of an HEp-2 cell culture according to polarographic study data]
Colitis
Mitochondrial electron transport chain complex dysfunction in the colonic mucosa in ulcerative colitis.
Colonic Neoplasms
GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation.
Human colon cancer tissues are more sensitive than rectal cancer tissues to antitumor drugs in vitro.
Colorectal Neoplasms
4'-O-tetrahydropyranyladriamycin has greater antineoplastic activity than adriamycin in various human tumours in vitro.
Colorectal carcinoma in vitro is more sensitive to 1-hexylcarbamoyl-5-fluorouracil compared with six other antitumor drugs: carboquone, Adriamycin, mitomycin C, aclacinomycin A, cisplatin, 5-fluorouracil.
Hereditary syndromes with associated renal neoplasia: a practical guide to histologic recognition in renal tumor resection specimens.
In vitro sensitivity of various human tumors to 1-beta-D-arabinofuranosylcytosine and N4-behenoyl-1-beta-D-arabinofuranosylcytosine.
Mutations in the coat complex II component SEC23B promote colorectal cancer metastasis.
Primary and metastatic liver lesions of clinical colorectal cancer differ in chemosensitivity.
Reduced succinate dehydrogenase B expression is associated with growth and de-differentiation of colorectal cancer cells.
Regulation of HLA-DR antigen in monocytes from colorectal cancer patients by in vitro treatment with human recombinant interferon-gamma.
[Human colorectal carcinoma is more sensitive to HCFU than 5-FU and tegafur in in vitro and in vivo drug sensitivity tests]
[The sensitivity of 1,000 human tumors to antitumor drugs using the succinate dehydrogenase inhibition (SDI) test]
Colorectal Neoplasms, Hereditary Nonpolyposis
Hereditary syndromes with associated renal neoplasia: a practical guide to histologic recognition in renal tumor resection specimens.
Coma
[Changes of some energy exchange parameters in the rat heart under insulin hypoglycemia]
[Enzyme activity and substrate levels of the Krebs cycle in the brain tissue of rats with insulin-induced hypoglycemia and during the recovery period]
[Intensity of glycolysis and activity of energy metabolism enzymes in rat brain after multiple exposures to hypoglycemic doses of insulin]
Communicable Diseases
Molecular Dynamics Simulations to Provide Insights into Epitopes Coupled to the Soluble and Membrane-Bound MHC-II Complexes.
Coronary Disease
[Disorders of myocardial metabolism in sudden coronary death in the presence of coronary atherosclerosis: findings of quantitative histoenzymologic studies]
[The relation between oxidative processes and the glycogen content in the heart and liver of rabbits with chronic ischemic heart disease]
Coronary Occlusion
[Effect of prolonged beta-adrenergic blockade on myocardial energy metabolism in coronary occlusion]
COVID-19
Global food security in the context of COVID-19: A scenario-based exploratory analysis.
Cranial Nerve Diseases
Head and neck paragangliomas: A two-decade institutional experience and algorithm for management.
Craniocerebral Trauma
[Lipid peroxidation processes and activity of brain succinate dehydrogenase in experimental craniocerebral trauma]
Crohn Disease
Nutrigenomics in the whole-genome scanning era: Crohn's disease as example.
Cryptorchidism
The effect of cryptorchidism on the quantitative histology, histochemistry and hydrolytic enzyme activity of the rat testis.
Cystic Fibrosis
Chemical and biological folding contribute to temperature-sensitive DeltaF508 CFTR trafficking.
QUANTITATIVE MICRODETERMINATION OF ENZYMES IN SWEAT GLAND. 3. SUCCINIC DEHYDROGENASE IN CYSTIC FIBROSIS.
Cysts
Effects of mebendazole, albendazole, and praziquantel on succinate dehydrogenase, fumarate reductase, and malate dehydrogenase in Echinococcus granulosus cysts harbored in mice.
Histoenzymological study of selected dehydrogenase enzymes in Pneumocystis carinii.
Sarcocystis fusiformis: some Krebs cycle enzymes in various fractions of sarcocysts of buffalo (Bubalus bubalis).
Cytochrome-c Oxidase Deficiency
A novel complex neurological phenotype due to a homozygous mutation in FDX2.
Analysis of the mitochondrial complex I-v enzyme activities of peripheral leukocytes in oxidative phosphorylation disorders.
Effect of Resveratrol on Cultured Skin Fibroblasts from Patients with Oxidative Phosphorylation Defects.
Increased risk for cardiorespiratory failure associated with the A3302G mutation in the mitochondrial DNA encoded tRNALeu(UUR) gene.
Predominant cerebellar volume loss as a neuroradiologic feature of pediatric respiratory chain defects.
Ragged red or ragged blue fibers.
The many clinical faces of cytochrome c oxidase deficiency.
When should MERRF (myoclonus epilepsy associated with ragged-red fibers) be the diagnosis?
[Clinical and investigative approaches in mitochondrial diseases. A review of 15 cases]
Deafness
Changes in the cochlear iron enzymes and adenosine triphosphatase in experimental iron deficiency.
Dehydration
[Fundamental studies on cytochemical demonstration of the succinic dehydrogenase system in the retina with the electron microscope. The effects on dinitroformazan and ultrastructure at the postfixation, the dehydration and the embedding]
[Fundamental studies on cytochemical demonstration of the succinic dehydrogenase system in the retina with the electron microscope. The effects on dinitroformazan on fixation and dehydration]
[Ultrastructural localization of succinate dehydrogenase in the myocardium with the use of partial dehydration and with an embedding medium mixable with water]
Dementia
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
The AIDS dementia complex: II. Neuropathology.
Demyelinating Diseases
Age Influences Microglial Activation After Cuprizone-Induced Demyelination.
Dental Caries
[Distribution of succinic dehydrogenase in dental caries (author's transl)]
Dermatomycoses
Effect of sodium ethylmercurithiosalicylate on succinic dehydrogenase of Candida albicans and its clinical use in dermatomycoses.
Diabetes Mellitus
Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus.
[Effect of insulin therapy and hyperbaric oxygenation on the enzyme activity of tissue metabolism in diabetes mellitus]
[Intervention effect of ganoderma lucidum spores on the changes of XOD, MPO and SDH in the testis tissue of NIDDM rats]
Diabetes Mellitus, Experimental
Alloxan diabetes in Swiss mice: activity of Na(+)-K(+)-ATPase and succinic dehydrogenase.
SUCCINIC DEHYDROGENASE ACTIVITY OF CARDIAC MUSCLE IN ANIMALS WITH EXPERIMENTALLY INDUCED MYOCARDITIS AND ALLOXAN DIABETES.
Diabetes Mellitus, Type 1
Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes.
Normal to enhanced intrinsic mitochondrial respiration in skeletal muscle of middle- to older-aged women and men with uncomplicated type 1 diabetes.
[The sulfhydryl groups and succinate dehydrogenase activity of the peripheral blood lymphocytes in diabetic patients]
Diabetes Mellitus, Type 2
Abnormalities in the fiber composition and capillary architecture in the soleus muscle of type 2 diabetic Goto-Kakizaki rats.
Exercise training prevents decrease in luminal capillary diameter of skeletal muscles in rats with type 2 diabetes.
Mild Hyperbaric Oxygen Improves Decreased Oxidative Capacity of Spinal Motoneurons Innervating the Soleus Muscle of Rats with Type 2 Diabetes.
Progression of type 2 diabetes in GK rats affects muscle and liver mitochondria differently: pronounced reduction of complex II flux is observed in liver only.
Diabetes, Gestational
Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus.
Diabetic Cardiomyopathies
Streptozotocin-induced diabetic cardiomyopathy in rats: ameliorative effect of PIPERINE via Bcl2, Bax/Bcl2, and caspase-3 pathways.
dihydrolipoyl dehydrogenase deficiency
The expanding clinical spectrum of mitochondrial diseases.
Diphtheria
Histochemical alterations in succinic dehydrogenase activity of guinea pig tissues following administration of diphtheria toxin.
[Lymphocyte and neutrophil cytochemistry in the dynamics of different forms of diphtheria in adults]
Down Syndrome
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Drug Hypersensitivity Syndrome
A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes.
Dystonia
Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic treated rats.
Dopamine toxicity following long term exposure to low doses of 3-nitropropionic acid (3-NPA) in rats.
In vitro response of mitochondrial succinate oxidase system to epinephrine in human blood lymphocytes from health individuals and patients with neurocirculatory dystonia.
[Some mechanisms of pathogenesis of hypertonic type neurocirculatory dystonia in flying personnel]
Eczema
Increased succinate dehydrogenase activity of lymphocytes in eczema.
Embolism
Effects of monochlorobimane on cerebral ischemia-induced damage to mitochondria.
Possible therapeutic effect of naftidrofuryl oxalate on brain energy metabolism after microsphere-induced cerebral embolism.
Encephalitis, Tick-Borne
Neutrophil apoptosis induction by tick-borne encephalitis virus.
[Histochemical study of the activity of several enzymes in the process of immunogenesis in monkeys orally infected with viruses of the tick-borne encephalitis complex]
Encephalomyelitis
Inhibition of brain macrophage/microglial respiratory chain enzyme activity in experimental autoimmune encephalomyelitis of the Lewis rat.
[Study of some oxidoreductases in nerve tissue culture]
Encephalomyelitis, Autoimmune, Experimental
Inhibition of brain macrophage/microglial respiratory chain enzyme activity in experimental autoimmune encephalomyelitis of the Lewis rat.
Endocrine Gland Neoplasms
Exploring the association of succinate dehydrogenase complex mutations with lymphoid malignancies.
Endometrial Neoplasms
Melatonin alleviates progression of uterine endometrial cancer by suppressing estrogen/ubiquitin C/SDHB-mediated succinate accumulation.
Endometriosis
A potential role of Sirtuin3 and its target enzyme activities in patients with ovarian endometrioma.
Endotoxemia
Attenuation of sepsis-related immunoparalysis by continuous veno-venous hemofiltration in experimental porcine pancreatitis.
Effect of bacterial endotoxemia on succinic dehydrogenase of liver and kidney of rabbit.
The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.
[The effect of triamcinolone acetonide on the liver mitochondria in endotoxemia]
Eosinophilia
Blood eosinophilia and major histocompatibility complex II expression in renal allograft rejection.
Histological and histochemical examinations of myocardium of rats kept on low-magnesium diet and receiving methotrexate.
Histological and histochemical examinations of the myocardium of rats kept on low-magnesium diet and treated with cyclophosphamide.
Ependymoma
The activity of succinic dehydrogenase in the experimental ependymoma of C3H mice.
Epidermolysis Bullosa Acquisita
IgG Fc N-Glycosylation Translates MHCII Haplotype into Autoimmune Skin Disease.
Epilepsies, Myoclonic
Cytochrome c oxidase activity is deficient in blood vessels of patients with myoclonus epilepsy with ragged-red fibers.
Erythema
Epidermal changes in human skin following irradiation with either UVB or UVA.
Esophageal Neoplasms
Effectiveness of hyperthermia and radiation treatments for patients with esophageal cancer predicted by the succinate dehydrogenase inhibition test.
Hyperthermo-radiosensitivity of esophageal cancer cells with high DNA ploidy in vitro.
[Hyperthermo-chemo-radiotherapy of patients with carcinoma of the esophagus and prediction of the clinical remedial value using the in vitro succinate dehydrogenase inhibition test]
Eye Diseases
Autoantibodies to the flavoprotein subunit of succinate dehydrogenase: analysis of specificity in autoimmune thyroid disease.
Fatty Liver
A Combination of Mitochondrial Oxidative Stress and Excess Fat/Calorie Intake Accelerates Steatohepatitis by Enhancing Hepatic CC Chemokine Production in Mice.
Identification of novel molecular candidates for fatty liver in the hyperlipidemic mouse model, HcB19.
Optical determination of fatty change of the graft liver with near-infrared time-resolved spectroscopy.
Fibrous Dysplasia, Polyostotic
An update on the genetics of benign pituitary adenomas in children and adolescents.
Genetics of gigantism and acromegaly.
Pituitary gigantism: update on molecular biology and management.
Friedreich Ataxia
Abnormalities of mitochondrial enzymes in hereditary ataxias.
fumarate hydratase deficiency
The expanding clinical spectrum of mitochondrial diseases.
Ganglion Cysts
[Effect of Alternanthera philoxeroides on enzymic histochemistry of oncomelania hupensis]
Gastritis
Gastrin-releasing peptide receptor antagonist or N-acetylcysteine combined with omeprazol protect against mitochondrial complex II inhibition in a rat model of gastritis.
[Activity of various intracellular enzymes of the gastric mucosa in chronic gastritis and tumors]
[Billroth II.Surgery of the stomach]
Gastritis, Atrophic
Variations of energy metabolism and adenosine triphosphatase activity in gastric mucosa in chronic atrophic gastritis rats with Qi deficiency and blood stasis syndrome and effect of zhiweifangbian capsule.
Gastrointestinal Diseases
SUCCINIC DEHYDROGENASE ACTIVITY AND HISTOLOGICAL CHANGES OF THE SMALL INTESTINAL MUCOSA IN PATIENTS WITH GASTROINTESTINAL DISEASES.
Gastrointestinal Stromal Tumors
18F-FDG PET/CT Monitoring of Tumor Response to Tyrosine Kinase Inhibitors and Alkylating Drugs in an SDH-Deficient GIST.
A bittersweet symphony.
A distinct pediatric-type gastrointestinal stromal tumor in adults: potential role of succinate dehydrogenase subunit A mutations.
A high-throughput analysis of the IDH1(R132H) protein expression in pituitary adenomas.
Aberrant Splicing of SDHC in Families With Unexplained Succinate Dehydrogenase-Deficient Paragangliomas.
Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs.
Carney triad can be (rarely) associated with germline succinate dehydrogenase defects.
Carney-Stratakis syndrome: A dyad of familial paraganglioma and gastrointestinal stromal tumor.
Clinicopathologic study of succinate-dehydrogenase-deficient gastrointestinal stromal tumors: A single-institutional experience in China.
Conventional Risk Stratification Fails to Predict Progression of Succinate Dehydrogenase-deficient Gastrointestinal Stromal Tumors: A Clinicopathologic Study of 76 Cases.
Dedifferentiation in SDH-Deficient Gastrointestinal Stromal Tumor: A Report With Histologic, Immunophenotypic, and Molecular Characterization.
Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations.
Epigenetic Mutation of the Succinate Dehydrogenase C Promoter in a Patient With Two Paragangliomas.
Establishment of Patient-derived Succinate Dehydrogenase-deficient Gastrointestinal Stromal Tumor Models For Predicting Therapeutic Response.
Expression of IGF-1 receptor in KIT/PDGF receptor-? wild-type gastrointestinal stromal tumors with succinate dehydrogenase complex dysfunction.
Gain of TP53 Mutation in Imatinib-treated SDH-Deficient Gastrointestinal Stromal Tumor and Clinical Utilization of Targeted Next-generation Sequencing Panel for Therapeutic Decision Support.
Gastrointestinal stromal tumour in succinate dehydrogenase subunit B mutation-associated familial phaeochromocytoma/paraganglioma.
Gastrointestinal stromal tumours: from KIT to succinate dehydrogenase.
Gene Expression Landscape of SDH-Deficient Gastrointestinal Stromal Tumors.
Genome-wide Analyses Identifies MEN1 and MAX Mutations and a Neuroendocrine-like Molecular Heterogeneity in Quadruple WT GIST.
Germline SDHA mutations in children and adults with cancer.
Good survival outcome of metastatic SDH-deficient gastrointestinal stromal tumors harboring SDHA mutations.
Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation.
In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDHx Mutations in Paraganglioma.
Loss of SDHA expression identifies SDHA mutations in succinate dehydrogenase-deficient gastrointestinal stromal tumors.
Loss of succinate dehydrogenase subunit B (SDHB) expression is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours: a comprehensive genotype-phenotype correlation study.
MDCT features of succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumours.
Molecular alterations and expression of succinate dehydrogenase complex in wild-type KIT/PDGFRA/BRAF gastrointestinal stromal tumors.
Mutational spectrum and classification of novel mutations in patients with metastatic gastrointestinal stromal tumours.
Preferential MGMT methylation could predispose a subset of KIT/PDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents.
Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors.
SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors.
SDHC epi-mutation testing in gastrointestinal stromal tumours and related tumours in clinical practice.
Simultaneous KIT mutation and succinate dehydrogenase (SDH) deficiency in a patient with a gastrointestinal stromal tumour and Carney-Stratakis syndrome: a case report.
Structural and functional consequences of succinate dehydrogenase subunit B mutations.
Succinate Dehydrogenase (SDH) D Subunit (SDHD) Inactivation in a Growth-Hormone-Producing Pituitary Tumor: A New Association for SDH?
Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors.
Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis.
Succinate dehydrogenase deficiency is rare in pituitary adenomas.
Succinate dehydrogenase deficient gastrointestinal stromal tumor in a three month old boy with a fatal clinical course: a case report and review of literature.
Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) - a review.
Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor.
Succinate Dehydrogenase Subunit B (SDHB) Is Expressed in Neurofibromatosis 1-Associated Gastrointestinal Stromal Tumors (Gists): Implications for the SDHB Expression Based Classification of Gists.
Succinate dehydrogenase-deficient gastrointestinal stromal tumor of stomach diagnosed by endoscopic ultrasound-guided fine-needle biopsy: Report of a distinct subtype in cytology.
Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumors.
Succinate dehydrogenase-deficient GISTs: a clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GISTs with predilection to young age.
Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma.
The phenotype of SDHB germline mutation carriers: a nationwide study.
The role of complex II in disease.
Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations.
Translating in vivo metabolomic analysis of succinate dehydrogenase deficient tumours into clinical utility.
Upregulation of ZNF148 in SDHB-deficient gastrointestinal stromal tumor potentiates Forkhead box M1-mediated transcription and promotes tumor cell invasion.
Utility of immunohistochemical investigation of SDHB and molecular genetic analysis of SDH genes in the differential diagnosis of mesenchymal tumors of GIT.
Utility of the succinate: Fumarate ratio for assessing SDH dysfunction in different tumor types.
[A 47-year-old patient with paroxysmal arterial hypertension and gastric tumors].
[Expression of succinate dehydrogenase subunit protein in succinate dehydrogenase-deficient gastrointestinal stromal tumors].
[Succinate dehydrogenase deficient gastrointestinal stromal tumor: a clinicopathologic analysis of eight cases].
Genetic Diseases, Inborn
Deficits of glutamate transmission in the striatum of toxic and genetic models of Huntington's disease.
Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas.
Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine.
Morphological clues to the appropriate recognition of hereditary renal neoplasms.
Phenotypic dichotomy in mitochondrial complex II genetic disorders.
Pheochromocytoma: Diagnostic and Therapeutic Update.
Gigantism
Genetics of gigantism and acromegaly.
Pituitary gigantism: update on molecular biology and management.
Glaucoma
Evidence Supporting an Association Between Expression of Major Histocompatibility Complex II by Microglia and Optic Nerve Degeneration During Experimental Glaucoma.
MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma.
Mitochondrial function is impaired in the primary visual cortex in an experimental glaucoma model.
[The acid phosphatase, alkaline phosphatase, lactate dehydrogenase, and succinate dehydrogenase in the endothelium on the trabecular meshwork in primary glaucoma]
Glioblastoma
Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.
Hepatocyte growth factor increases mitochondrial mass in glioblastoma cells.
Glioma
An oxidative stress mechanism of shikonin in human glioma cells.
Effect of hypoxia on the expression of nuclear genes encoding mitochondrial proteins in U87 glioma cells.
Enzymes related to energy metabolism in human gliomas.
Persian Gulf Snail Crude Venom (Conus textile): A Potential Source of Anti-Cancer Therapeutic Agents for Glioblastoma through Mitochondrial-Mediated Apoptosis.
Selection of suitable reference genes for expression analysis in human glioma using RT-qPCR.
ST1926 inhibits glioma progression through regulating mitochondrial complex II.
The activity of oxidative enzymes in short-term explant cultures of gliomas in vitro. I. Coenzyme I-bound dehydrogenases and succinate dehydrogenase.
Glomerulonephritis
[Changes of the activity of succinate dehydrogenase in patients with diffuse glomerulonephritis]
[Succinate dehydrogenase and alpha-glycerophosphate dehydrogenase activity in children with acute glomerulonephritis]
Glomus Tumor
18F-DOPA positron emission tomography for the detection of glomus tumours.
Functional study in a yeast model of a novel succinate dehydrogenase subunit B gene germline missense mutation (C191Y) diagnosed in a patient affected by a glomus tumor.
Germ-line mutations in nonsyndromic pheochromocytoma.
Goiter
Validation of reference genes for normalization gene expression in reverse transcription quantitative PCR in human normal thyroid and goiter tissue.
[The clinical importance of determining lymphocyte succinate dehydrogenase activity and the count of large granule-containing lymphocytes in the peripheral blood of patients with diffuse toxic goiter]
Granuloma
Cervical Lymph Nodes as a Selective Niche for Brucella during Oral Infections.
Effects of anti-inflammatory drugs on glutathione levels and liver succinic dehydrogenase activity in carrageenin edema and cotton pellet granuloma in rats.
Histochemical analysis of experimental granulomatous uveitis.
[Evaluation of the functional state of the leprous macrophages]
Granulomatosis with Polyangiitis
Upregulation of CD14 and CD18 on monocytes In vitro by antineutrophil cytoplasmic autoantibodies.
Graves Disease
Cytochemistry--a tool in thyroid pathology.
Cytoenzymologic activities of some oxidreductases in thyreopathies.
Eye muscle antibodies in patients with ocular myasthenia gravis: possible mechanism for eye muscle inflammation in acetylcholine-receptor antibody-negative patients.
Graves Ophthalmopathy
Autoantibodies to the flavoprotein subunit of succinate dehydrogenase: analysis of specificity in autoimmune thyroid disease.
Study of Serum Antibodies Against Three Eye Muscle Antigens and the Connective Tissue Antigen Collagen XIII in Patients with Graves' Disease With and Without Ophthalmopathy: Correlation With Clinical Features.
Hamartoma
Hereditary syndromes with associated renal neoplasia: a practical guide to histologic recognition in renal tumor resection specimens.
Hamartoma Syndrome, Multiple
Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation.
Succinate dehydrogenase gene variants and their role in Cowden syndrome.
Head and Neck Neoplasms
Succinate dehydrogenase inhibition test for evaluating head and neck tumors.
Targeting metabolic pathways for head and neck cancers therapeutics.
[Basic and clinical evaluation of the effect of pirarubicin against head and neck cancer--chemosensitivity test and a comparative study with doxorubicin]
Hearing Loss
Hydrogen-saturated saline protects intensive narrow band noise-induced hearing loss in guinea pigs through an antioxidant effect.
Hearing Loss, Sensorineural
Changes in the cochlear iron enzymes and adenosine triphosphatase in experimental iron deficiency.
Heart Arrest
Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest.
Heart Failure
Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy.
Depressed aerobic enzyme activity of skeletal muscle in severe chronic heart failure.
Effects of Ilexonin A on circulatory neuroregulation.
Effects of Zoniporide and BMA-1321 Compound on the Rate of Oxygen Absorption by Cardiomyocyte Mitochondria in Rats with Experimental Chronic Heart Failure.
Irreversible morphological changes contributing to depressed cardiac function after surgery for chronic aortic regurgitation.
Maximum rate of oxygen consumption related to succinate dehydrogenase activity in skeletal muscle fibres of chronic heart failure patients and controls.
Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.
[Evaluation of energy metabolism on the myocardium analyzing of creatine kinase isoenzymes in rats]
Heart Neoplasms
Functional Cardiac Paraganglioma Associated with a Rare SDHC Mutation.
Hemangioblastoma
Li-Fraumeni Syndrome and p53 in 2015: Celebrating their Silver Anniversary.
The loss of succinate dehydrogenase B expression is frequently identified in hemangioblastoma of the central nervous system.
Hepatitis
Association of Doberman hepatitis to canine major histocompatibility complex II.
[ATP SYNTHESIS AND SUCCINATE DEHYDROGENASE ACTIVITY OF SUSPENSIONS OF ISOLATED LIVER MITOCHONDRIA FROM SUBJECTS WITH ACUTE HEPATITIS.]
[NADH:ubiquinone reductase and succinate dehydrogenase activity in the liver of rats with acetaminophen-induced toxic hepatitis on the background of alimentary protein deficiency].
[Recent research on the enzymatic activity of the liver and blood in experimental MHV-3 virus hepatitis: adenylpyrophosphatase, succinic dehydrogenase, rhodanese and phosphoglucomutase.]
[The comparative characteristics of the indices of lymphocyte and neutrophil functional activity in patients with HIV infection and chronic viral hepatitis B]
Hepatitis A
[The significance of determining the peripheral blood succinate dehydrogenase in the lymphocytes and large granule-containing lymphocytes in diseases of the hepatobiliary system]
Hepatitis, Chronic
[The comparative characteristics of the indices of lymphocyte and neutrophil functional activity in patients with HIV infection and chronic viral hepatitis B]
Hepatolenticular Degeneration
Histochemical studies of fibroblasts from patients with Menkes kinky hair disease and Wilson's disease.
Herpes Zoster
Comparative histological and histochemical studies on the adrenal gland of the albino and the Egyptian desert rats.
Ultrastructural changes in mitochondria of the adrenal cortex of iron-deficient rats.
Hirschsprung Disease
A NOVEL DOUBLE MUTATION VAL648ILE AND VAL804LEU OF RET PROTO-ONCOGENE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2.
HIV Infections
[The comparative characteristics of the indices of lymphocyte and neutrophil functional activity in patients with HIV infection and chronic viral hepatitis B]
Hodgkin Disease
Disordered macrophage development in Hodgkin's disease shown by quantitative cytochemistry.
Huntington Disease
3-Nitropropionic acid activates calpain/cdk5 pathway in rat striatum.
3-nitropropionic acid-induced mitochondrial permeability transition: Comparative study of mitochondria from different tissues and brain regions.
A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin.
Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders.
An abnormal striatal synaptic plasticity may account for the selective neuronal vulnerability in Huntington's disease.
BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons.
Beneficial effect of (-)schisandrin B against 3-nitropropionic acid-induced cell death in PC12 cells.
Bioenergetics in fibroblasts of patients with Huntington disease are associated with age at onset.
Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology.
Cannabinoid CB(2) receptor agonists protect the striatum against malonate toxicity: Relevance for Huntington's disease.
Caspase-dependent and -independent cell death induced by 3-nitropropionic acid in rat cortical neurons.
Chronic intoxication with 3-nitropropionic acid in rats induces the loss of striatal dopamine terminals without affecting nigral cell viability.
Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway.
Decreased TCA cycle rate in the rat brain after acute 3-NP treatment measured by in vivo 1H-[13C] NMR spectroscopy.
Deficits of glutamate transmission in the striatum of toxic and genetic models of Huntington's disease.
Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic treated rats.
Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and gamma-glutamyl transpeptidase in post-mortem brain from Huntington's disease and agonal cases.
Dopamine mediates striatal malonate toxicity via dopamine transporter-dependent generation of reactive oxygen species and D2 but not D1 receptor activation.
Dopamine receptor agonists mediate neuroprotection in malonate-induced striatal lesion in the rat.
Effect of Pesticides on the Aggregation of Mutant Huntingtin Protein.
Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate.
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Glycogen accumulation in cardiomyocytes and cardiotoxic effects after 3NPA treatment.
Huntington's Disease: Astrocytes Shift to Fatty Acid Metabolism.
Inhibition of mitochondrial complex II alters striatal expression of genes involved in glutamatergic and dopaminergic signaling: possible implications for Huntington's disease.
LACK OF JNK3 DOES NOT PROTECT AGAINST NEURODEGENERATION INDUCED BY 3-NITROPROPIONIC ACID.
Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system.
Malonate-induced generation of reactive oxygen species in rat striatum depends on dopamine release but not on NMDA receptor activation.
Mechanism of 3-nitropropionic acid-induced membrane permeability transition of isolated mitochondria and its suppression by L-carnitine.
Metabolic Profiling of 3-Nitropropionic Acid Early-Stage Huntington's Disease Rat Model Using Gas Chromatography Time-of-Flight Mass Spectrometry.
Mitochondrial dysfunction in movement disorders.
Mitochondrial Inhibitor Models of Huntington's Disease and Parkinson's Disease Induce Zinc Accumulation and Are Attenuated by Inhibition of Zinc Neurotoxicity in vitro or in vivo.
Mitochondrial modulators improve lipid composition and attenuate memory deficits in experimental model of Huntington's disease.
Mitochondrial Respiratory Function in Peripheral Blood Cells from Huntington's Disease Patients.
Mutant SOD1G93A in bone marrow-derived cells exacerbates 3-nitropropionic acid induced striatal damage in mice.
Neuronal vulnerability following inhibition of mitochondrial complex II: a possible ionic mechanism for Huntington's disease.
Neuroprotective effects mediated by dopamine receptor agonists against malonate-induced lesion in the rat striatum.
Neuroprotective mechanisms of brain-derived neurotrophic factor against 3-nitropropionic acid toxicity: therapeutic implications for Huntington's disease.
Neuroprotective potential of escitalopram against behavioral, mitochondrial and oxidative dysfunction induced by 3-nitropropionic acid.
NF-kB/NOS cross-talk induced by mitochondrial complex II inhibition: Implications for Huntington's disease.
Oral uridine pro-drug PN401 decreases neurodegeneration, behavioral impairment, weight loss and mortality in the 3-nitropropionic acid mitochondrial toxin model of Huntington's disease.
Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease.
Oxidative stress and mitochondrial dysfunction in neurodegeneration.
Partial inhibition of brain succinate dehydrogenase by 3-nitropropionic acid is sufficient to initiate striatal degeneration in rat.
Phosphate-activated glutaminase in relation to Huntington's disease and agonal state.
Promethazine Protects Against 3-Nitropropionic Acid-induced Neurotoxicity.
Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription.
Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate.
Role of Nrf2-dependent ARE-driven antioxidant pathway in neuroprotection.
Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington's Disease: Role of CB(1) and CB(2) Receptors.
Serial 1H-NMR spectroscopy study of metabolic impairment in primates chronically treated with the succinate dehydrogenase inhibitor 3-nitropropionic acid.
Striatal degeneration induced by mitochondrial blockade is prevented by biologically delivered NGF.
Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity.
Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition.
The critical threshold of 3-nitropropionic acid-induced ischemic tolerance in the rat.
The effect of Ginkgo biloba extract on 3-nitropropionic acid-induced neurotoxicity in rats.
The mitochondrial toxin, 3-nitropropionic acid, induces extracellular Zn2+ accumulation in rat hippocampus slices.
Tiagabine, a GABA uptake inhibitor, attenuates 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters in rats.
Topological analysis of striatal lesions induced by 3-nitropropionic acid in the Lewis rat.
[Model of Huntington's disease induced with 3-nitropropionic acid]
Hyperglycemia
Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction.
Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders.
Protective effect of theaflavin on glycoprotein components and TCA cycle enzymes in high-fat diet and streptozotocin-induced diabetic rats.
Superoxide production by mitochondria of insulin-sensitive tissues: mechanistic differences and effect of early diabetes.
Hyperhomocysteinemia
Severe Hyperhomocysteinemia Decreases Respiratory Enzyme and Na(+)-K(+) ATPase Activities, and Leads to Mitochondrial Alterations in Rat Amygdala.
Hyperlipidemias
Placental permeability and energy metabolism enzymes in fetuses of lipemic rats.
Hyperparathyroidism, Primary
AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2? SIGNALING.
Hyperpigmentation
Impact of hyperpigmentation on superoxide flux and melanoma cell metabolism at mitochondrial complex II.
Hypersensitivity
Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant.
Knockdown of Succinate Dehydrogenase Assembly Factor 2 Induces Reactive Oxygen Species-Mediated Auxin Hypersensitivity Causing pH-dependent Root Elongation.
Hypersensitivity, Delayed
Levamisole in infectious diseases--a review of the literature.
Hypertension
Cardiac hypertrophy in spontaneously hypertensive rats.
Familial paragangliomas: case report and literature review.
Rats with Human Mutation of NFU1 Develop Pulmonary Hypertension.
THE METABOLISM OF THE KIDNEY IN EXPERIMENTAL RENAL HYPERTENSION : II. THE CONCENTRATION OF CYTOCHROME C AND THE ACTIVITIES OF THE CYTOCHROME OXIDASE AND OF THE SUCCINIC DEHYDROGENASE SYSTEMS IN THE KIDNEY OF DOGS WITH EXPERIMENTAL RENAL HYPERTENSION. THE INHIBITORY EFFECT OF RENIN AND OF KIDNEY TISSUE PREPARATIONS FROM HYPERTENSIVE DOGS ON THE RESPIRATORY ENZYMES.
[A correlation of the intensity of the gas discharge luminescence of the skin and the activity of succinate dehydrogenase in blood lymphocytes in different states of the body]
[Determination of dehydrogenase and acid phosphatase activity in the lymphocytes in hypertension and vasorenal hypertension]
[Metabolic effects of mexidol in complex treatment of chronic brain ischemia]
[Na+--K+-adenosine triphosphatase and some oxidoreductases in the kidney of rats with spontaneous hypertension]
[The oxygen-transport function of the blood and cell metabolism in patients with heart failure of different origins]
[Treatment of patients with hypertonic disease with plasmapheresis]
Hypertension, Pulmonary
Persistent pulmonary hypertension results in reduced tetralinoleoyl-cardiolipin and Complex II + III activity in neonatal pig heart.
Hypertension, Renal
THE METABOLISM OF THE KIDNEY IN EXPERIMENTAL RENAL HYPERTENSION : II. THE CONCENTRATION OF CYTOCHROME C AND THE ACTIVITIES OF THE CYTOCHROME OXIDASE AND OF THE SUCCINIC DEHYDROGENASE SYSTEMS IN THE KIDNEY OF DOGS WITH EXPERIMENTAL RENAL HYPERTENSION. THE INHIBITORY EFFECT OF RENIN AND OF KIDNEY TISSUE PREPARATIONS FROM HYPERTENSIVE DOGS ON THE RESPIRATORY ENZYMES.
Hypertension, Renovascular
[Functional activity of the structures of the medulla oblongata in rats with arterial hypertension of renal origin (histoenzymological research)]
Hyperthyroidism
Alleviation of enhanced oxidative stress and oxygen consumption of L-thyroxine induced hyperthyroid rat liver mitochondria by vitamin E and curcumin.
Autoantibodies to the flavoprotein subunit of succinate dehydrogenase: analysis of specificity in autoimmune thyroid disease.
Central core degeneration after tenotomy in soleus muscles of hyperthyroid rats.
Effects of hyper- and hypothyroidism on thyroid hormone concentrations in regions of the rat brain.
Eye muscle antibodies in patients with ocular myasthenia gravis: possible mechanism for eye muscle inflammation in acetylcholine-receptor antibody-negative patients.
Serum antibodies against the flavoprotein subunit of succinate dehydrogenase are sensitive markers of eye muscle autoimmunity in patients with Graves' hyperthyroidism.
The 64-kilodalton eye muscle protein is the flavoprotein subunit of mitochondrial succinate dehydrogenase: the corresponding serum antibodies are good markers of an immune-mediated damage to the eye muscle in patients with Graves' hyperthyroidism.
Hypokinesia
[Activity of oxidative enzymes of the tricarboxylic acid cycle in the liver of rats during hypokinesia]
[Activity of various oxidases and transaminases in the rat liver in the readaptation period after hypokinesia up to 30 days]
[Changes in the mitochondrial oxidative enzyme activity in the skeletal muscles od rats during the recovery period after hypokinesia of varying duration]
[Histophysiology and histopathology of the adrenals in experimental hypokinesia]
[Oxidative enzyme activity of the tricarboxylic acid cycle in rat skeletal muscles in hypokinesia]
[Succinate dehydrogenase and cytochrome oxidase activity in rat tissues during prolonged hypokinesia]
Hypothyroidism
Mitochondrial oxidative enzyme activity in individual fibre types in hypo- and hyperthyroid rat skeletal muscles.
Peroxisomal oxidative capacity of brown adipose tissue depends on the thyroid status.
Hypoxia, Brain
Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: neuroprotective role of L-carnitine.
Hypoxia-Ischemia, Brain
[Peculiarity of cell energy metabolism in newborns with hypoxic-ischemic encephalopathy caused by asphyxia]
Ichthyosis Vulgaris
Enzyme histochemistry of the small intestine in inherited ichthyosis.
Infarction, Middle Cerebral Artery
Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model.
Infections
A persistent giant algal virus, with a unique morphology, encodes an unprecedented number of genes involved in energy metabolism.
A Salmonella enterica serovar typhimurium succinate dehydrogenase/fumarate reductase double mutant is avirulent and immunogenic in BALB/c mice.
Activities of membrane bound phosphatases, transaminases and mitochondrial enzymes in white spot syndrome virus infected tissues of Fenneropenaeus indicus.
Analysis of recombinant and native CD4 by one- and two-dimensional gel electrophoresis.
Analysis of the differential host cell nuclear proteome induced by attenuated and virulent hemorrhagic arenavirus infection.
Arbuscular mycorrhizal fungi mediated uptake of lanthanum in Chinese milk vetch (Astragalus sinicus L.).
Biochemical studies in infective amosite pneumoconiosis.
Brugia malayi: status of host during different stages of infection.
Differential immune-related gene expression in the spleens of duck Tembusu virus-infected goslings.
Effect of an essential fatty acid deficient diet on experimental infection with Trypanosoma cruzi in germfree and conventional mice.
Effect of infection with M. tuberculosis and of tuberculin shock on the succinic dehydrogenase activity of guinea pig tissues.
Effect of infection with Mycobacterium tuberculosis and BCG on the lactic dehydrogenase and succinic dehydrogenase activity of guinea pig liver.
Effect of sodium stibogluconate on hepatic mixed function oxidase system and marker enzymes of golden hamsters during Leishmania donovani infection.
Evaluation of reference genes for real-time PCR studies of Brazilian Somalis sheep infected by gastrointestinal nematodes.
Experimental concomitant toxoplasma and malaria infection in rats.
Interferon Gamma Reprograms Host Mitochondrial Metabolism through Inhibition of Complex II To Control Intracellular Bacterial Replication.
Isolation and characterization of the stage-specific cytochrome b small subunit (CybS) of Ascaris suum complex II from the aerobic respiratory chain of larval mitochondria.
Manganese superoxide dismutase deficiency exacerbates the mitochondrial ROS production and oxidative damage in Chagas disease.
Mechanisms of Pathogenesis in Listeria monocytogenes Infection IV. Hepatic Carbohydrate Metabolism and Function in Experimental Listeriosis.
Nitric oxide and KLF4 protein epigenetically modify class II transactivator to repress major histocompatibility complex II expression during Mycobacterium bovis bacillus Calmette-Guerin infection.
Phosphorylation-guarded light-harvesting complex II contributes to broad-spectrum blast resistance in rice.
Poliovirus induces an early impairment of mitochondrial function by inhibiting succinate dehydrogenase activity.
STUDIES ON THE DISTRIBUTION AND ACTIVITY OF SUCCINIC DEHYDROGENASE IN MUSCLE TISSUE DURING INFECTION WITH TRICHINELLAE.
Time course of oxidative stress, lesion and edema after intrastriatal injection of malonate in rat: effect of alpha-phenyl-N-tert-butylnitrone.
TRK-Fused Gene (TFG), a protein involved in protein secretion pathways, is an essential component of the antiviral innate immune response.
[Effect of a mixed E. coli O-111 (RNA-azopositive and RNA-azonegative strains) and Coxsackie B3 viral infection on oxygen demand and on the succinate dehydrogenase activity of an HEp-2 cell culture according to polarographic study data]
[Exploring the effects of artesunate and fuzheng huayu decoction on mitochondria in the treatment of schistosomiasis liver fibrosis].
[Metabolic aspects of hepatic tissue in infection of the mouse from EDP virus. III. Adenypyrophosphatase, succinic dehydrogenase and rhodanese activity.]
[Succinate dehydrogenase, NAD-H2- and NADPH-H2-diaphorase activity in a herpetic infection of a cell culture]
[The changes in succinate dehydrogenase activity in Detroit-6 (VA) cells as a result of infection with the hepatitis-infectious-virus]
[The role of mononuclear phagocytes in the immunopathogenesis of HIV infection]
Infertility
Infertility and recurrent miscarriage with complex II deficiency-dependent mitochondrial oxidative stress in animal models.
Mitochondrial reactive oxygen species generation by the SDHC V69E mutation causes low birth weight and neonatal growth retardation.
Infertility, Male
Possible mitochondrial involvement in mechanism of cytoplasmic male sterility in maize (Zea mays L.).
Single nucleotide polymorphisms in succinate dehydrogenase subunits and citrate synthase genes: association results for impaired spermatogenesis.
Influenza, Human
Highly conserved cross-reactive CD4+ T-cell HA-epitopes of seasonal and the 2009 pandemic influenza viruses.
The effect of malonate on succinic dehydrogenase (SDH) activity during the multiplication of influenza and herpes viruses in the embryonate hen egg.
Insulin Resistance
Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats.
Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness.
Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.
Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity.
SirT3 regulates diabetogenic effects caused by arsenic: An implication for mitochondrial complex II modification.
Intestinal Obstruction
[Effect of hyperbaric oxygenation on the succinate dehydrogenase and cytochrome oxidase activity of the visceral organs in intestinal obstruction]
Intracranial Arteriosclerosis
[Metabolic effects of mexidol in complex treatment of chronic brain ischemia]
Intracranial Embolism
In vitro effect of naftidrofuryl oxalate on cerebral mitochondria impaired by microsphere-induced embolism in rats.
Iron Deficiencies
Biochemical effects of mild iron deficiency and cold acclimatization on rat skeletal muscle.
Changes in the cochlear iron enzymes and adenosine triphosphatase in experimental iron deficiency.
Effect of Fe deficiency on mitochondrial alternative NAD(P)H dehydrogenases in cucumber roots.
Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease.
Interrelationship between iron deficiency and lead intoxication (Part 2).
Iron enzymes in iron deficiency. V. Succinic dehydrogenase in rat liver, kidney and heart.
The activity of tissue enzymes in iron-deficient rat and man: an overview.
The Cth2 ARE-binding Protein Recruits the Dhh1 Helicase to Promote the Decay of Succinate Dehydrogenase SDH4 mRNA in Response to Iron Deficiency.
Will latent iron deficiency affect the mitochondrial iron-containing enzymes?
Iron Overload
Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease.
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.
Ischemic Stroke
Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate.
Kearns-Sayre Syndrome
Expression of oxidative phosphorylation genes in muscle cell cultures from patients with mitochondrial myopathies.
Kearns-Sayre syndrome and complex II deficiency.
Keratosis
A quantitative histochemical study of three oxidative enzymes in solar keratoses and Bowen's disease.
Clinical response and tissue effects of etretinate treatment of patients with solar keratoses and basal cell carcinoma.
Quantitative changes in respiratory enzyme activity in premalignant lesions and experimentally irradiated skin.
Keratosis, Seborrheic
Senile and seborrheic keratoses; localization of succinic dehydrogenase, protein-bound sulfhydryl, and disulfide groups.
Ketosis
The use of transgenic and mutant mice to study oxygen free radical metabolism.
[Experimental studies on the ketogenic effect of high doses of proteins in dairy cows]
Kidney Failure, Chronic
[Cephalothin and platelet enzymes in chronic renal failures]
Kidney Neoplasms
Genetic basis of kidney cancer: role of genomics for the development of disease-based therapeutics.
Hereditary kidney cancer syndromes.
Hereditary syndromes with associated renal neoplasia: a practical guide to histologic recognition in renal tumor resection specimens.
In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDHx Mutations in Paraganglioma.
Morphological clues to the appropriate recognition of hereditary renal neoplasms.
Primary Renal Paragangliomas and Renal Neoplasia Associated with Pheochromocytoma/Paraganglioma: Analysis of von Hippel-Lindau (VHL), Succinate Dehydrogenase (SDHX) and Transmembrane Protein 127 (TMEM127).
Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer.
Succinate Dehydrogenase-Deficient Renal Cancer Featuring Fructose-1,6-Biphosphatase Loss, Pyruvate Kinase M2 Overexpression, and SWI/SNF Chromatin Remodeling Complex Aberrations: A Rare Case Report.
The metabolic basis of kidney cancer.
Treatment of succinate dehydrogenase B-associated renal cancer.
Urological cancer related to familial syndromes.
Vascular Endothelial Growth Factor Receptor-Targeted Therapy in Succinate Dehydrogenase C Kidney Cancer.
Leigh Disease
Compound heterozygous mutations in the flavoprotein gene of the respiratory chain complex II in a patient with Leigh syndrome.
Deficiency in complex II of the respiratory chain, presenting as a leukodystrophy in two sisters with Leigh syndrome.
Diagnosis and treatment in a case of juvenile subacute necrotizing encephalopathy Leigh without cytochrome c oxidase deficiency.
Leigh syndrome caused by mutations in the flavoprotein (Fp) subunit of succinate dehydrogenase (SDHA).
Mitochondrial DNA mutations in Leigh syndrome and their phylogenetic implications.
Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency.
Novel variant p.(Ala102Thr) in SDHB causes mitochondrial complex II deficiency: Case report and review of the literature.
Phenotypic variability of mitochondrial disease caused by a nuclear mutation in complex II.
SDHA mutations causing a multisystem mitochondrial disease: novel mutations and genetic overlap with hereditary tumors.
The role of complex II in disease.
[Leigh syndrome and leukodystrophy due to partial succinate dehydrogenase deficiency: regression with riboflavin]
[Leigh syndrome due to mitochondrial respiratory chain complex II deficiency].
Leiomyoma
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
Immunohistochemical Characterization of Fumarate Hydratase (FH) and Succinate Dehydrogenase (SDH) in Cutaneous Leiomyomas for Detection of Familial Cancer Syndromes.
Mitochondrial mutations in cancer.
Utility of immunohistochemical investigation of SDHB and molecular genetic analysis of SDH genes in the differential diagnosis of mesenchymal tumors of GIT.
Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?
Leiomyomatosis
Aerobic glycolysis: a novel target in kidney cancer.
Clinical and morphologic review of 60 hereditary renal tumors from 30 hereditary renal cell carcinoma syndrome patients: lessons from a contemporary single institution series.
Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability.
Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair.
Molecular genetics and immunohistochemistry characterization of uncommon and recently described renal cell carcinomas.
Morphological clues to the appropriate recognition of hereditary renal neoplasms.
Urological cancer related to familial syndromes.
Leiomyosarcoma
Antitumor chemosensitivity differs between clinical sarcoma and adenocarcinoma tissues.
Utility of immunohistochemical investigation of SDHB and molecular genetic analysis of SDH genes in the differential diagnosis of mesenchymal tumors of GIT.
Leprosy, Lepromatous
[Evaluation of the functional state of the leprous macrophages]
Leukemia
A recurrent stop-codon mutation in succinate dehydrogenase subunit B gene in normal peripheral blood and childhood T-cell acute leukemia.
Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II.
Cytoenzymochemical effects of some antiblastic drugs and prediction of response to chemotherapy in acute leukemias.
HISTOCHEMICAL STUDIES OF BLOOD CELLS IN LEUKEMIA. OBSERVATIONS ON PEROXIDASE AND SUCCINIC DEHYDROGENASE.
Oncophosphosignaling Favors a Glycolytic Phenotype in Human Drug Resistant Leukemia.
Shikimic acid complexes of platinum. Preparation, reactivity, and antitumor activity of (R,R-1,2-diaminocyclohexane) bis(shikimato) platinum(II). Evidence for a novel rearrangement involving platinum-carbon bond formation.
Venetolax with Azacitidine Drains Fuel from AML Stem Cells.
[Activity of succinate dehydrogenase in blast cells of bone marrow of children in acute leukemia]
Leukemia, Lymphoid
Antitumor agents. XXXV: Effects of brusatol, bruceoside A, and bruceantin on P-388 lymphocytic leukemia cell respiration.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Succinic dehydrogenase activity in chronic myeloid leukemia.
Leukoencephalopathies
A variant of uncertain significance in SDHAF1, the succinate dehydrogenase chaperone protein, in an adult patient with spastic paraparesis and leukoencephalopathy.
Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB.
Leukoencephalopathy due to Complex II Deficiency and Bi-Allelic SDHB Mutations: Further Cases and Implications for Genetic Counselling.
Leukoencephalopathy with accumulated succinate is indicative of SDHAF1 related complex II deficiency.
Magnetic resonance imaging spectrum of succinate dehydrogenase-related infantile leukoencephalopathy.
Mitochondrial leukoencephalopathy and complex II deficiency associated with a recessive SDHB mutation with reduced penetrance.
SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy.
Li-Fraumeni Syndrome
Li-Fraumeni Syndrome and p53 in 2015: Celebrating their Silver Anniversary.
Lipomatosis
Loss of Mitochondrial SDHB Expression: What is its Role in Diffuse Thyroid Lipomatosis?
Liposarcoma
Antitumor chemosensitivity differs between clinical sarcoma and adenocarcinoma tissues.
Liver Failure
Acute hepatic failure with swollen mitochondria and microvesicular fatty degeneration of hepatocytes triggered by free radical initiator.
Liver Neoplasms
Chemosensitivity test for carcinoma of digestive organs.
Sensitivity to six antitumor drugs differs between primary and metastatic liver cancers.
[Effect of invigorating spleen and detoxification decoction on MHC I/MHC II in spleen-deficiency liver cancer rats survival].
Liver Neoplasms, Experimental
Characteristics of mitochondria isolated by rate zonal centrifugation from normal liver and Novikoff hepatomas.
Lung Injury
Experimental lung injury promotes alterations in energy metabolism and respiratory mechanics in the lungs of rats: prevention by exercise.
Lung Neoplasms
4'-O-tetrahydropyranyladriamycin has greater antineoplastic activity than adriamycin in various human tumours in vitro.
Chemopreventive effect of piperine on mitochondrial TCA cycle and phase-I and glutathione-metabolizing enzymes in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice.
Chemosensitivity testing of human lung cancer tissues using the succinate dehydrogenase inhibition test.
Effect of mangiferin on benzo(a)pyrene induced lung carcinogenesis in experimental Swiss albino mice.
Modulation of TCA cycle enzymes and electron transport chain systems in experimental lung cancer.
PD-L1 regulation by SDH5 via ?-catenin/ZEB1 signaling.
SDH5 Depletion Enhances Radiosensitivity by Regulating p53: A New Method for Noninvasive Prediction of Radiotherapy Response.
Succinate dehydrogenase 5(SDH5) regulate (GSK)-3?-?-catenin-mediated lung cancer metastasis.
The predictability of clinical antitumor effects using two distinctive in vitro chemosensitivity tests: an analysis of true positive cases.
[Comparative study of Coptidis Rhizoma and Aconiti Kusnezoffii Radix on cell differentiation in lewis lung cancer].
Lupus Erythematosus, Systemic
Autoantibodies to the flavoprotein subunit of succinate dehydrogenase: analysis of specificity in autoimmune thyroid disease.
Epigenetic modulation of RFC1, MHC2TA and HLA-DR in systemic lupus erythematosus: association with serological markers and six functional polymorphisms of one-carbon metabolic pathway.
Lymphadenopathy
Cervical Lymph Nodes as a Selective Niche for Brucella during Oral Infections.
Lymphoma
Advances in Renal Neoplasia: Recommendations From the 2012 International Society of Urological Pathology Consensus Conference.
Apurinic/apyrimidinic endonuclease/redox factor 1 (APE1) alleviates myocardial hypoxia-reoxygenation injury by inhibiting oxidative stress and ameliorating mitochondrial dysfunction.
Contemporary update on pathology-related issues of adult renal neoplasms.
Effect of cisplatin on mitochondrial protein, glutathione, and succinate dehydrogenase in Dalton lymphoma-bearing mice.
Structural and biochemical changes in mitochondria after cisplatin treatment of Dalton's lymphoma-bearing mice.
Studies of human malignant lymphomas after treatment with endoxan. I. Cytochemical studies in the respiratory enzymes succinic dehydrogenase and cytochrome oxidase.
Succinate dehydrogenase inhibition test for evaluating head and neck tumors.
Turn up the cellular power generator with vitamin E analogue formulation.
[In vitro chemosensitivity of various human tumors evaluated by the succinate dehydrogenase inhibition (SDI) test (2)]
[Vancouver classification of renal tumors : Recommendations of the 2012 consensus conference of the International Society of Urological Pathology (ISUP).]
Lymphoma, B-Cell
A Salmonella typhi OmpC fusion protein expressing the CD154 Trp140-Ser149 amino acid strand binds CD40 and activates a lymphoma B-cell line.
Apurinic/apyrimidinic endonuclease/redox factor 1 (APE1) alleviates myocardial hypoxia-reoxygenation injury by inhibiting oxidative stress and ameliorating mitochondrial dysfunction.
Mitochondrial dysfunction in the hippocampus of rats caused by chronic oxidative stress.
Streptozotocin-induced diabetic cardiomyopathy in rats: ameliorative effect of PIPERINE via Bcl2, Bax/Bcl2, and caspase-3 pathways.
Turn up the cellular power generator with vitamin E analogue formulation.
Lymphoma, Non-Hodgkin
Abnormalities of esterase and glycogen in developing macrophages in non-Hodgkin's lymphoma: a quantitative cytochemical study.
Lymphopenia
Effect of dietary intake on immune function in athletes.
[Comparative study of platinum complexes in athymic mice with human tumors]
Machado-Joseph Disease
Compromised mitochondrial complex II in models of Machado-Joseph disease.
Malaria
Critical roles of the mitochondrial complex II in oocyst formation of rodent malaria parasite Plasmodium berghei.
Identification of mitochondrial Complex II subunits SDH3 and SDH4 and ATP synthase subunits a and b in Plasmodium spp.
[The dynamic activity of lymphocyte succinate dehydrogenase and its correlations in experimental malaria]
Malnutrition
Effect of undernutrition on succinate dehydrogenase and acetylcholinesterase in developing rat brain.
Postnatal regulation of myosin heavy chain isoform expression and metabolic enzyme activity by nutrition.
The effects of pre- and perinatal undernutrition on the succinic dehydrogenase content of muscle fibres from fast and slow rat muscles.
Undernutrition and the developing rat brain. I. Influence on acetylcholinesterase and succinic acid dehydrogenase activities and on norepinephrine and 5-OH-tryptamine tissue concentrations.
[The succinic dehydrogenase activity of the heart and skeletal muscle of the pigeon with bradycardia produced by complete inanition or by orizanin-induced malnutrition.]
Manganese Poisoning
[Variations in the succinate dehydrogenase activity of albino rats fed protein-rich diet during manganese poisoning]
Mastitis
[Histochemical behavior of succinate dehydrogenase and lactate dehydrogenase as well as ribonucleic acid in the epithelium of lactic ducts and alveoli of cow udder]
Measles
Isoenzymes of succinate dehydrogenase in measles virus-infected monkey kidney cells.
Melanoma
Activity of some respiratory and lysosomal enzymes of lymphocytes in golden hamster with induced melanoma.
Impact of hyperpigmentation on superoxide flux and melanoma cell metabolism at mitochondrial complex II.
Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine.
Metabolic characterization of three hamster melanoma variants.
Nickel oxide nanoparticles exert selective toxicity on skin mitochondria and lysosomes isolated from the mouse model of melanoma.
Melanoma, Amelanotic
Metabolic characterization of three hamster melanoma variants.
Melanoma, Experimental
5-Fluorouracil's cytotoxicity is enhanced both in vitro and in vivo by concomitant treatment with hyperthermia and dipyridamole.
MELAS Syndrome
Expression of oxidative phosphorylation genes in muscle cell cultures from patients with mitochondrial myopathies.
Histochemical and molecular genetic study of MELAS and MERRF in Korean patients.
Molecular neuropathology of MELAS: level of heteroplasmy in individual neurones and evidence of extensive vascular involvement.
The m.3243A>G mtDNA mutation is pathogenic in an in vitro model of the human blood brain barrier.
When should MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes) be the diagnosis?
[MELAS without ragged-red fibers: a case report]
Memory Disorders
Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders.
Meningioma
Alterations of oxidative phosphorylation in meningiomas and peripheral nerve sheath tumors.
Meningitis
Evaluation of mitochondrial respiratory chain in the brain of rats after pneumococcal meningitis.
Meningoencephalitis
[Ultrastructural location of enzymes in peripheral blood neutrophils and in cerebrospinal fluid neutrophils in neuroinfections]
Menkes Kinky Hair Syndrome
Histochemical studies of fibroblasts from patients with Menkes kinky hair disease and Wilson's disease.
MERRF Syndrome
When should MERRF (myoclonus epilepsy associated with ragged-red fibers) be the diagnosis?
Metabolic Diseases
Electron transport chain defect and inefficient respiration may underlie pulmonary hypertension syndrome (ascites)-associated mitochondrial dysfunction in broilers.
Inhibition of the mitochondrial respiratory chain by alanine in rat cerebral cortex.
The metabolic basis of kidney cancer.
Methemoglobinemia
Roles of Nitrocompounds in Inhibition of Foodborne Bacteria, Parasites, and Methane Production in Economic Animals.
Microcephaly
Bixafen, a succinate dehydrogenase inhibitor fungicide, causes microcephaly and motor neuron axon defects during development.
Microscopic Polyangiitis
Upregulation of CD14 and CD18 on monocytes In vitro by antineutrophil cytoplasmic autoantibodies.
Mitochondrial Diseases
Consolidating biallelic SDHD variants as a cause of mitochondrial complex II deficiency.
Crystal structure of mitochondrial respiratory membrane protein complex II.
Direct evidence for two distinct forms of the flavoprotein subunit of human mitochondrial complex II (succinate-ubiquinone reductase).
Effects of riboflavin in children with complex II deficiency.
Exome sequencing identifies NFS1 deficiency in a novel Fe-S cluster disease, infantile mitochondrial complex II/III deficiency.
Identification of inheritance modes of mitochondrial diseases by introduction of pure nuclei from mtDNA-less HeLa cells to patient-derived fibroblasts.
Leukoencephalopathy due to Complex II Deficiency and Bi-Allelic SDHB Mutations: Further Cases and Implications for Genetic Counselling.
Leukoencephalopathy with accumulated succinate is indicative of SDHAF1 related complex II deficiency.
Mitochondrial complex II has a key role in mitochondrial-derived reactive oxygen species influence on plant stress gene regulation and defense.
Mitochondrial leukoencephalopathy and complex II deficiency associated with a recessive SDHB mutation with reduced penetrance.
Mitochondrial myopathy, cardiomyopathy, and pontine signal changes in an adult patient with isolated complex II deficiency.
Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency.
Phenotypic variability of mitochondrial disease caused by a nuclear mutation in complex II.
Predominant cerebellar volume loss as a neuroradiologic feature of pediatric respiratory chain defects.
Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency.
Relationship of primary mitochondrial respiratory chain dysfunction to fiber type abnormalities in skeletal muscle.
SDHA mutation with dominant transmission results in complex II deficiency with ocular, cardiac, and neurologic involvement.
SDHA mutations causing a multisystem mitochondrial disease: novel mutations and genetic overlap with hereditary tumors.
The effect of small molecules on nuclear-encoded translation diseases.
The genetic basis of isolated mitochondrial complex II deficiency.
The stability and activity of respiratory Complex II is cardiolipin-dependent.
[Leigh syndrome due to mitochondrial respiratory chain complex II deficiency].
Mitochondrial Encephalomyopathies
Predominant cerebellar volume loss as a neuroradiologic feature of pediatric respiratory chain defects.
Succinate in dystrophic white matter: a proton magnetic resonance spectroscopy finding characteristic for complex II deficiency.
[A case of mitochondrial encephalomyopathy with myoclonic attacks, hyper-lactic-pyruvic acidemia, and decreased activities of complex II and cytochrome c oxidase]
Mitochondrial Myopathies
A hereditary mitochondrial myopathy with low succinate dehydrogenase activity in northern Sweden.
A patient with mitochondrial myopathy associated with isolated succinate dehydrogenase deficiency.
Dependence of maximum performance time on work intensity in patients with a hereditary myopathy with succinate dehydrogenase deficiency.
Different laboratory and muscle biopsy findings in a family with an m.8851T>C mutation in the mitochondrial MTATP6 gene.
Enzyme histochemical study of germanium dioxide-induced mitochondrial myopathy in rats.
Hypertrophic cardiomyopathy with mitochondrial myopathy. A new phenotype of complex II defect.
Mitochondrial myopathy with succinate dehydrogenase and aconitase deficiency. Abnormalities of several iron-sulfur proteins.
Mitochondrial myopathy, cardiomyopathy, and pontine signal changes in an adult patient with isolated complex II deficiency.
Quantitative succinate dehydrogenase analysis in normal and ragged-red muscle fibers.
Riboflavin transporter deficiency mimicking mitochondrial myopathy caused by complex II deficiency.
Strongly succinate dehydrogenase-reactive blood vessels in muscles from patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.
Succinate Dehydrogenase B (SDHB) Immunohistochemistry for the Evaluation of Muscle Biopsies.
Succinate dehydrogenase deficiency.
[Mitochondrial DNA depletion in mitochondrial myopathy caused by complex II and IV deficiency of the respiratory chain]
Mitral Valve Stenosis
[Histochemical study of succinate dehydrogenase in the atrium of subjects with rheumatic mitral stenosis]
Multiple Endocrine Neoplasia
18F-FDG Avidity of Pheochromocytomas and Paragangliomas: A New Molecular Imaging Signature?
6-18F-Fluoro-L-Dihydroxyphenylalanine Positron Emission Tomography Is Superior to 123I-Metaiodobenzyl-Guanidine Scintigraphy in the Detection of Extraadrenal and Hereditary Pheochromocytomas and Paragangliomas: Correlation with Vesicular Monoamine Transporter Expression.
A NOVEL DOUBLE MUTATION VAL648ILE AND VAL804LEU OF RET PROTO-ONCOGENE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2.
AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2? SIGNALING.
An update on the genetics of benign pituitary adenomas in children and adolescents.
Characteristics of pheochromocytoma in a 4- to 20-year-old population.
Childhood phaeochromocytoma and paraganglioma: 100% incidence of genetic mutations and 100% survival.
Clinicopathological, immunophenotypic and genetic studies of mediastinal paragangliomas.
Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas.
Epigenetic analysis of HIC1, CASP8, FLIP, TSP1, DCR1, DCR2, DR4, DR5, KvDMR1, H19 and preferential 11p15.5 maternal-allele loss in von Hippel-Lindau and sporadic phaeochromocytomas.
FDOPA Patterns in Adrenal Glands: A Pictorial Essay.
Genetic testing for pheochromocytoma-associated syndromes.
Genetic testing in pheochromocytoma: increasing importance for clinical decision making.
Genetics of gigantism and acromegaly.
Genetics of phaeochromocytoma.
Germ-line mutations in nonsyndromic pheochromocytoma.
Over-representation of the G12S polymorphism of the SDHD gene in patients with MEN2A syndrome.
Phaeochromocytoma in children.
Phaeochromocytoma.
Pheochromocytoma and paraganglioma syndromes: genetics and management update.
Pheochromocytoma: an update on genetics and management.
Pheochromocytoma: Diagnostic and Therapeutic Update.
Pheochromocytoma: the expanding genetic differential diagnosis.
Pheochromocytomas and Paragangliomas: An Update on Recent Molecular Genetic Advances and Criteria for Malignancy.
Pituitary gigantism: update on molecular biology and management.
Recent advances in the diagnosis and treatment of pheochromocytoma.
SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma-paraganglioma syndromes.
Synchronous adrenocortical neoplasms, paragangliomas, and pheochromocytomas: syndromic considerations regarding an unusual constellation of endocrine tumors.
The genetic landscape of gastrointestinal stromal tumor lacking KIT and PDGFRA mutations.
UPDATE ON THE CLINICOPATHOLOGY OF PITUITARY ADENOMAS.
Multiple Endocrine Neoplasia Type 1
An update on the genetics of benign pituitary adenomas in children and adolescents.
Genetics of gigantism and acromegaly.
Pheochromocytoma: an update on genetics and management.
Multiple Endocrine Neoplasia Type 2a
18F-FDG Avidity of Pheochromocytomas and Paragangliomas: A New Molecular Imaging Signature?
AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2? SIGNALING.
Characteristics of pheochromocytoma in a 4- to 20-year-old population.
Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas.
Epigenetic analysis of HIC1, CASP8, FLIP, TSP1, DCR1, DCR2, DR4, DR5, KvDMR1, H19 and preferential 11p15.5 maternal-allele loss in von Hippel-Lindau and sporadic phaeochromocytomas.
Genetic testing for pheochromocytoma-associated syndromes.
Genetic testing in pheochromocytoma: increasing importance for clinical decision making.
Genetics of phaeochromocytoma.
Germ-line mutations in nonsyndromic pheochromocytoma.
Over-representation of the G12S polymorphism of the SDHD gene in patients with MEN2A syndrome.
Phaeochromocytoma in children.
Phaeochromocytoma.
Pheochromocytoma and paraganglioma syndromes: genetics and management update.
Pheochromocytoma: Diagnostic and Therapeutic Update.
Pheochromocytoma: the expanding genetic differential diagnosis.
Pheochromocytomas and Paragangliomas: An Update on Recent Molecular Genetic Advances and Criteria for Malignancy.
Recent advances in the diagnosis and treatment of pheochromocytoma.
SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma-paraganglioma syndromes.
Multiple Endocrine Neoplasia Type 2b
Characteristics of pheochromocytoma in a 4- to 20-year-old population.
Multiple Myeloma
Chidamide, a novel histone deacetylase inhibitor, inhibits multiple myeloma cells proliferation through succinate dehydrogenase subunit A.
High Expression of Succinate Dehydrogenase Subunit A Which Is Regulated by Histone Acetylation, Acts as a Good Prognostic Factor of Multiple Myeloma Patients.
Muscle Hypotonia
Exome sequencing identifies NFS1 deficiency in a novel Fe-S cluster disease, infantile mitochondrial complex II/III deficiency.
Muscle Weakness
Biochemical changes in primary culture of skeletal muscle cells following dimethoate exposure.
Effect of endurance and/or strength training on muscle fiber size, oxidative capacity, and capillarity in hemodialysis patients.
Multiple defects of the respiratory chain including complex II in a family with myopathy and encephalopathy.
Progressive myopathy with a combined respiratory chain defect including Complex II.
Muscular Diseases
A novel de novo dominant mutation in
Clinical manifestation and a new ISCU mutation in iron-sulphur cluster deficiency myopathy.
Dependence of maximum performance time on work intensity in patients with a hereditary myopathy with succinate dehydrogenase deficiency.
Hereditary myopathy with lactic acidosis, succinate dehydrogenase and aconitase deficiency in northern Sweden: a genealogical study.
Late-onset optic atrophy, ataxia, and myopathy associated with a mutation of a complex II gene.
Low succinate dehydrogenase (SDH) activity in a patient with a hereditary myopathy with paroxysmal myoglobinuria.
Mitochondrial respiration of complex II is not lower than that of complex I in mouse skeletal muscle.
Multiple defects of the respiratory chain including complex II in a family with myopathy and encephalopathy.
Progressive myopathy with a combined respiratory chain defect including Complex II.
Sarcoid myopathy and mitochondrial respiratory chain defects: clinicopathological, biochemical and molecular biological analyses.
Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.
Structure and dynamics of the iron-sulfur cluster assembly scaffold protein IscU and its interaction with the cochaperone HscB.
Transient restoration of succinate dehydrogenase activity after rhabdomyolysis in iron-sulphur cluster deficiency myopathy.
[Changes in muscle fibers of the somatic type in experimental thyrotoxic myopathy]
[Hereditary myopathy with succinate dehydrogenase deficiency--a rare life-threatening disease]
[Histochemical research on some muscular diseases modifying proteins with -SH groups and succinate dehydrogenase activity]
[Myopathy due to succinate cytochrome C oxidoreductase deficiency: possible defect of complex II of the respiratory chain]
Muscular Disorders, Atrophic
Hot and steady: Elevated temperatures do not enhance muscle disuse atrophy during prolonged aestivation in the ectotherm Cyclorana alboguttata.
SUCCINIC DEHYDROGENASE IN PIGEON PECTORALIS DURING DISUSE ATROPHY.
Muscular Dystrophies
Alterations in succinic dehydrogenase activity at different stages of muscular dystrophy in the mouse.
Succinic dehydrogenase in muscular dystrophy. An experimental study on secondary changes resulting from disturbance in neuromuscular integrity.
[Changes in the activity of succinate dehydrogenase and lactate dehydrogenase in the muscles of patients with progressive muscular dystrophy]
Myasthenia Gravis
Eye muscle antibodies in patients with ocular myasthenia gravis: possible mechanism for eye muscle inflammation in acetylcholine-receptor antibody-negative patients.
Mycoses
A dispensable paralog of succinate dehydrogenase subunit C mediates standing resistance towards a subclass of SDHI fungicides in Zymoseptoria tritici.
A rapid molecular detection system for SdhB and SdhC point mutations conferring differential SDHI resistance in populations of Clarireedia.
Isoflucypram cardiovascular toxicity in zebrafish (Danio rerio).
Sensitivity of Meloidogyne incognita and Rotylenchulus reniformis to Fluopyram.
Myocardial Infarction
Citric Acid Cycle Metabolites Predict Infarct Size in Pigs Submitted to Transient Coronary Artery Occlusion and Treated with Succinate Dehydrogenase Inhibitors or Remote Ischemic Perconditioning.
Determination of potassium/sodium ratio in heart tissue. Evaluation of its use as an index of myocardial ischaemic damage. Comparison with the nitro-BT test.
Oxidative modifications of mitochondria complex II.
Peroxynitrite-mediated oxidative modifications of complex II: relevance in myocardial infarction.
Relationship between energy liberation and utilization in ischemic cardiac muscle.
Succinic dehydrogenase activity in myocardial infarction and in induced myocardial necrosis.
The value of succinate dehydrogenase stain in the post-mortem diagnosis of early acute myocardial infarction. A forensic study.
[Cardiomyocytes of the left ventricle of the heart in experimental infarct and pharmacostimulation (histochemical study)]
[Effect of experimental myocardial infarct on the succinate oxidation rate and succinate dehydrogenase activity in the heart mitochondria]
[Effect of nonachlazine on the energy provision for cardiac contractile activity in experimental myocardial infarct]
Myocardial Ischemia
Middle age aggravates myocardial ischemia through surprising upholding of complex II activity, oxidative stress, and reduced coronary perfusion.
Myocarditis
A HISTOCHEMICAL STUDY OF SUCCINIC DEHYDROGENASE ACTIVITY IN EXPERIMENTAL DIPHTHERITIC MYOCARDITIS.
Analysis of mitochondrial antigens reveals inner membrane succinate dehydrogenase flavoprotein subunit as autoantigen to antibodies in anti-M7 sera.
SUCCINIC DEHYDROGENASE ACTIVITY OF CARDIAC MUSCLE IN ANIMALS WITH EXPERIMENTALLY INDUCED MYOCARDITIS AND ALLOXAN DIABETES.
Therapeutic effect of recombinant lentiviral vector containing succinate dehydrogenase iron-sulfur protein on the treatment of experimental autoimmunity myocarditis.
[Changes in the enzymatic activity in the myocardium of patients with idiopathic and secondary dilated cardiomyopathy]
[Effect of strophanthin and digoxin on the activity of succinate and lactate dehydrogenases and membrane Na+, K+-ATPase in the heart of rats with experimental myocarditis]
Myoglobinuria
Hereditary myopathy with lactic acidosis, succinate dehydrogenase and aconitase deficiency in northern Sweden: a genealogical study.
Low succinate dehydrogenase (SDH) activity in a patient with a hereditary myopathy with paroxysmal myoglobinuria.
Mitochondrial myopathy with succinate dehydrogenase and aconitase deficiency. Abnormalities of several iron-sulfur proteins.
Progressive myopathy with a combined respiratory chain defect including Complex II.
Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.
Myopathy, Central Core
Central core disease associated with scoliosis: report of one case.
Myositis
Succinate Dehydrogenase B (SDHB) Immunohistochemistry for the Evaluation of Muscle Biopsies.
Myotonic Dystrophy
Succinic dehydrogenase activity in skeletal muscle of normals and patients with dystrophia myotonica.
Myxoma
COMPARISON OF THE REDUCING POWER OF SOME TYPICAL TRANSPLANTABLE TUMORS AND OF TUMORS PRODUCED BY FILTERABLE VIRUSES : WITH AN APPENDIX ON THE METABOLISM OF INFECTIOUS MYXOMA OF THE RABBIT.
nadh:ubiquinone reductase (h+-translocating) deficiency
Analysis of the mitochondrial complex I-v enzyme activities of peripheral leukocytes in oxidative phosphorylation disorders.
Clinical spectrum, morbidity, and mortality in 113 pediatric patients with mitochondrial disease.
Increased risk for cardiorespiratory failure associated with the A3302G mutation in the mitochondrial DNA encoded tRNALeu(UUR) gene.
Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling.
Predominant cerebellar volume loss as a neuroradiologic feature of pediatric respiratory chain defects.
Secondary metabolic effects in complex I deficiency.
The importance of liver biopsy in the investigation of possible mitochondrial respiratory chain disease.
Nasal Polyps
Effect of macrolides on the expression of HLA-DR and costimulatory molecules on antigen-presenting cells in nasal polyps.
Nasopharyngeal Carcinoma
Down-regulation of succinate dehydrogenase subunit B and up-regulation of pyruvate dehydrogenase kinase 1 predicts poor prognosis in recurrent nasopharyngeal carcinoma.
The effect of three-dimensional conformal radiotherapy on locally recurrent nasopharyngeal carcinoma and on the expression of succinate dehydrogenase B.
[Low expression of succinate dehydrogenase subunit B in locally recurrent nasopharyngeal carcinoma and implication for prognosis].
Nasopharyngeal Neoplasms
Multiple Paraganglioma Syndrome type 4 Secondary to Succinate Dehydrogenase B Mutation: The Diagnostic and Therapeutic Challenges of a Skull Base Paraganglioma Masquerading as Nasopharyngeal Cancer.
Necrobiotic Disorders
Selective inhibition patterns of succinic dehydrogenase and local necrobiosis in tubules of rat kidney induced by six mercurial diuretics.
Neoplasm Metastasis
A Large Deletion in the Succinate Dehydrogenase B Gene (SDHB) in a Japanese Patient with Abdominal Paraganglioma and Concomitant Metastasis.
Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene.
Characterization of Malignant Head and Neck Paragangliomas at a Single Institution Across Multiple Decades.
Enhancement of pulmonary tumour seeding by human coagulation factors II, IX, X--an investigation into the possible mechanisms involved.
Experimentally induced colon cancer metastases in rat liver increase the proliferation rate and capacity for purine catabolism in liver cells.
Failure of MIBG scan to detect metastases in SDHB-mutated pediatric metastatic pheochromocytoma.
L157X nonsense mutation of the succinate dehydrogenase subunit B gene in a Japanese patient with right paraaortic paraganglioma.
Large Retroperitoneal Paraganglioma Associated with Germline Mutation of the Succinate Dehydrogenase Gene.
Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization.
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.
Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations.
Mutations in the coat complex II component SEC23B promote colorectal cancer metastasis.
Novel Mutation (L157X) in the Succinate Dehydrogenase B Gene (SDHB) in a Japanese Family with Abdominal Paraganglioma Following Lung Metastasis.
Paraganglioma: Cytomorphologic features, radiologic and clinical findings in 12 cases.
Paragangliomas: update on differential diagnostic considerations, composite tumors, and recent genetic developments.
Pathologic grading for predicting metastasis in phaeochromocytoma and paraganglioma.
PD-L1 regulation by SDH5 via ?-catenin/ZEB1 signaling.
Pheochromocytoma: A Clinicopathologic and Molecular Study of 390 Cases From a Single Center.
R46Q mutation in the succinate dehydrogenase B gene (SDHB) in a Japanese family with both abdominal and thoracic paraganglioma following metastasis.
Recurrent familial malignant carotid body tumour presenting with lymph node metastasis: case report, and review of diagnosis and management of familial carotid body tumours.
Risk Stratification on Pheochromocytoma and Paraganglioma from Laboratory and Clinical Medicine.
Successful chemotherapy of hepatic metastases in a case of succinate dehydrogenase subunit B-related paraganglioma.
Succinate dehydrogenase 5(SDH5) regulate (GSK)-3?-?-catenin-mediated lung cancer metastasis.
Thyroid Paraganglioma.
Transketolase regulates the metabolic switch to control breast cancer cell metastasis via the alpha-ketoglutarate signaling pathway.
[Expression of SDHB, EPAS1 and MIB-1 in Zuckerkandl paragangliomas].
Neoplasms
(18)F-fluorodihydroxyphenylalanine PET/CT in pheochromocytoma and paraganglioma: relation to genotype and amino acid transport system L.
1-Hexylcarbamoyl-5-fluorouracil is more cytostatic than 5-fluorouracil against human tumors in vitro.
18F-FDG Avidity of Pheochromocytomas and Paragangliomas: A New Molecular Imaging Signature?
18F-FDG PET/CT Monitoring of Tumor Response to Tyrosine Kinase Inhibitors and Alkylating Drugs in an SDH-Deficient GIST.
2-Methoxyestradiol Affects Mitochondrial Biogenesis Pathway and Succinate Dehydrogenase Complex Flavoprotein Subunit A in Osteosarcoma Cancer Cells.
4'-O-tetrahydropyranyladriamycin has greater antineoplastic activity than adriamycin in various human tumours in vitro.
5-Fluorouracil is converted to F-nucleotides more extensively and is more cytotoxic in poorly differentiated than in well differentiated human gastric carcinoma.
5-Fluorouracil's cytotoxicity is enhanced both in vitro and in vivo by concomitant treatment with hyperthermia and dipyridamole.
6-18F-Fluoro-L-Dihydroxyphenylalanine Positron Emission Tomography Is Superior to 123I-Metaiodobenzyl-Guanidine Scintigraphy in the Detection of Extraadrenal and Hereditary Pheochromocytomas and Paragangliomas: Correlation with Vesicular Monoamine Transporter Expression.
?-Tocopheryl succinate-suppressed development of cerebral malaria in mice.
A biochemical evaluation of oral squamous cell carcinoma growth by measurement of specific activity of succinate dehydrogenase in the subrenal capsule assay.
A bittersweet symphony.
A case of Carney triad complicated by renal cell carcinoma and a germline SDHA pathogenic variant.
A conditional mouse model of complex II deficiency manifesting as Leigh-like syndrome.
A conditional mouse mutant in the tumor suppressor SdhD gene unveils a link between p21(WAF1/Cip1) induction and mitochondrial dysfunction.
A distinct pediatric-type gastrointestinal stromal tumor in adults: potential role of succinate dehydrogenase subunit A mutations.
A feasibility study of the SDI test for the evaluation of gastrointestinal cancer sensitivity to anticancer drugs.
A giant cystic pheochromocytoma of the adrenal gland.
A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.
A high-throughput analysis of the IDH1(R132H) protein expression in pituitary adenomas.
A high-throughput screen for single gene activities: isolation of apoptosis inducers.
A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II.
A NOVEL DOUBLE MUTATION VAL648ILE AND VAL804LEU OF RET PROTO-ONCOGENE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2.
A novel G106D alteration of the SDHD gene in a pedigree with familial paraganglioma.
A Novel germline SDHD mutation in a patient with recurrent familial carotid body tumor and concomitant pheochromocytoma.
A Previously Unrecognized Monocytic Component of Pheochromocytoma and Paraganglioma.
A review of the tumour spectrum of germline succinate dehydrogenase gene mutations: Beyond phaeochromocytoma and paraganglioma.
A SDHB malignant paraganglioma with dramatic response to temozolomide-capecitabine.
A spectrophotometric coupled enzyme assay to measure the activity of succinate dehydrogenase.
A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/- rats.
Aberrant DNA hypermethylation of SDHC: a novel mechanism of tumor development in Carney triad.
Aberrant Splicing of SDHC in Families With Unexplained Succinate Dehydrogenase-Deficient Paragangliomas.
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.
Activation of hypoxia-inducible factor -1? via succinate dehydrogenase pathway during acute lung injury induced by trauma/hemorrhagic shock.
Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer.
Adrenocortical carcinoma and succinate dehydrogenase gene mutations.
Adrenocortical oncocytoma presenting as Cushing's syndrome: an additional report of a paediatric case.
Advances in paraganglioma-pheochromocytoma cell lines and xenografts.
Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells.
Alterations of oxidative phosphorylation complexes in astrocytomas.
Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs.
Altitude is a phenotypic modifier in hereditary paraganglioma type 1: evidence for an oxygen-sensing defect.
AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2? SIGNALING.
An anticancer agent, pyrvinium pamoate inhibits the NADH-fumarate reductase system--a unique mitochondrial energy metabolism in tumour microenvironments.
An evaluation of carcinogenicity predictors from short-term and sub chronic repeat-dose studies of agrochemicals in rats: Opportunities to refine and reduce animal use.
An update on the genetics of benign pituitary adenomas in children and adolescents.
Analysis of succinate dehydrogenase subunit B gene alterations in gastric cancers.
Androgen receptor (AR) antagonism triggers acute succinate-mediated adaptive responses to reactivate AR signaling.
Antitumor effect of i.p. dopamine in mice bearing Ehrlich ascites carcinoma.
Assessment of MR Imaging and CT in Differentiating Hereditary and Nonhereditary Paragangliomas.
Association of Dasatinib With Progression-Free Survival Among Patients With Advanced Gastrointestinal Stromal Tumors Resistant to Imatinib.
BACTERIOSTATIC CHEMOTHERAPEUTIC AND MALIGNANT TUMOR GROWTH; HISTOCHEMICAL CHANGE OF HEPATIC SUCCINIC DEHYDROGENASE ACTIVITY UNDER PROLONGED ADMINISTRATION OF BACTERIOSTATIC CHEMOTHERAPEUTIC ON THE RATS.
Biochemical studies on mitochondria isolated from Normal and Neoplastic Tissues of the Mouse Mammary Gland.
Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance.
Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness.
Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells.
Brief report: biomarkers of aortic vascular prosthetic graft infection in a porcine model with Staphylococcus aureus.
C/EBP? expression is an independent predictor of overall survival in breast cancer patients by MHCII/CD4-dependent mechanism of metastasis formation.
Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases.
Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III.
Cancer Cell-Specific Major Histocompatibility Complex II Expression as a Determinant of the Immune Infiltrate Organization and Function in the NSCLC Tumor Microenvironment.
Cancer-cell traffic in the liver. II. Arrest, transit and death of B16F10 and M5076 cells in the sinusoids.
Cardiac Paraganglioma Arising From the Right Atrioventricular Groove in a Paraganglioma-Pheochromocytoma Family Syndrome With Evidence of SDHB Gene Mutation: An Unusual Presentation.
Cardiac paraganglioma with a novel germline mutation of succinate dehydrogenase gene D.
Carney triad can be (rarely) associated with germline succinate dehydrogenase defects.
Carney-Stratakis syndrome: A dyad of familial paraganglioma and gastrointestinal stromal tumor.
Carotid body tumors in humans caused by a mutation in the gene for succinate dehydrogenase D (SDHD).
Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria.
Catecholamine metabolomic and secretory phenotypes in phaeochromocytoma.
Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells.
Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer.
CHARACTERISTICS AND OUTCOMES OF METASTATIC SDHB AND SPORADIC PHEOCHROMOCYTOMA/PARAGANGLIOMA: AN NATIONAL INSTITUTES OF HEALTH STUDY.
Characteristics of pheochromocytoma in a 4- to 20-year-old population.
Characterization and metabolic synthetic lethal testing in a new model of SDH-loss familial pheochromocytoma and paraganglioma.
Characterization of Malignant Head and Neck Paragangliomas at a Single Institution Across Multiple Decades.
Characterization of the metabolism of perinecrotic cells in solid tumors by enzyme histochemistry.
Chemosensitivity testing with highly purified fresh human tumour cells with the MTT colorimetric assay.
Childhood phaeochromocytoma and paraganglioma: 100% incidence of genetic mutations and 100% survival.
Chromatographic methods coupled to mass spectrometry for the determination of oncometabolites in biological samples-A review.
Cisplatin treatment renders tumor cells more susceptible to attack by lymphokine-activated killer cells.
Clear cell sarcoma of soft tissue with eccrine differentiation: A case report and review of the literature.
Clinical and molecular progress in hereditary paraganglioma.
Clinical and morphologic review of 60 hereditary renal tumors from 30 hereditary renal cell carcinoma syndrome patients: lessons from a contemporary single institution series.
Clinical significance and peculiarities of succinate dehydrogenase B and hypoxia inducible factor 1? expression in parasympathetic versus sympathetic paragangliomas.
Clinicopathologic Characteristics and Mutational Status of Succinate Dehydrogenase Genes in Paraganglioma of the Urinary Bladder: A Multi-Institutional Korean Study.
Clinicopathologic features of succinate dehydrogenase deficiencient renal cell carcinoma.
Clinicopathologic study of succinate-dehydrogenase-deficient gastrointestinal stromal tumors: A single-institutional experience in China.
Clinicopathological study of SDHB mutation-related pheochromocytoma and sympathetic paraganglioma.
Clinicopathological, immunophenotypic and genetic studies of mediastinal paragangliomas.
Colorimetric estimation of succinic dehydrogenase activity by neotetrazolium chloride as a tumor sensitivity test to chemotherapeutic agents.
Combination of 13-Cis retinoic acid and lovastatin: marked antitumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice.
Comparison between succinate dehydrogenase inhibition test and subrenal capsule assay for chemosensitivity testing.
Comparison of Ehrlich ascites tumour and mouse liver cells by analytical subcellular fractionation combined with a sensitive computational method for data analysis.
COMPARISON OF THE REDUCING POWER OF SOME TYPICAL TRANSPLANTABLE TUMORS AND OF TUMORS PRODUCED BY FILTERABLE VIRUSES : WITH AN APPENDIX ON THE METABOLISM OF INFECTIOUS MYXOMA OF THE RABBIT.
Comparison of the subrenal capsule assay and succinate dehydrogenase inhibition test as drug sensitivity tests for cancer.
Comparison of the subrenal capsule assay and succinate dehydrogenase inhibition test.
Comprehensive review of evaluation and management of cardiac paragangliomas.
Contemporary Characterization and Recategorization of Adult Unclassified Renal Cell Carcinoma.
Contemporary update on pathology-related issues of adult renal neoplasms.
Continued Tumor Reduction of Metastatic Pheochromocytoma/Paraganglioma Harboring Succinate Dehydrogenase Subunit B Mutations with Cyclical Chemotherapy.
Conventional Risk Stratification Fails to Predict Progression of Succinate Dehydrogenase-deficient Gastrointestinal Stromal Tumors: A Clinicopathologic Study of 76 Cases.
Correction: Tumour risks and genotype-phenotype correlations associated with germline variants in the succinate dehydrogenase subunit genes SDHB, SDHC, and SDHD.
Correlation Between In Vivo 18F-FDG PET and Immunohistochemical Markers of Glucose Uptake and Metabolism in Pheochromocytoma and Paraganglioma.
Corrigendum: Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III.
Counseling patients with succinate dehydrogenase subunit defects: genetics, preventive guidelines, and dealing with uncertainty.
Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation.
Current and future therapeutic approaches for metastatic pheochromocytoma and paraganglioma: focus on SDHB tumors.
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect.
Dedifferentiation in SDH-Deficient Gastrointestinal Stromal Tumor: A Report With Histologic, Immunophenotypic, and Molecular Characterization.
Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations.
Diagnostic Investigation of Lesions Associated with Succinate Dehydrogenase Defects.
Differential distribution of B16F10 melanoma cells in the liver lobule.
Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas.
Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart.
Direct evidence for two distinct forms of the flavoprotein subunit of human mitochondrial complex II (succinate-ubiquinone reductase).
Dopamine-Secreting Paraganglioma in the Retroperitoneum.
Down-regulation of succinate dehydrogenase subunit B and up-regulation of pyruvate dehydrogenase kinase 1 predicts poor prognosis in recurrent nasopharyngeal carcinoma.
Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors.
Effects of danazol on proliferation and viability of 7,12-dimethylbenz(a)anthracene-induced mammary tumours in rats.
Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.
Endocrine tumors associated with the vagus nerve.
Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.
Enhancement of cytotoxic T lymphocyte activity by dendritic cells loaded with Tat-protein transduction domain-fused hepatitis B virus core antigen.
Enhancement of tumor cell susceptibility to lymphokine-activated killer cells by treatment with the streptococcal preparation OK432.
Environmental strains of Mycobacterium avium interfere with immune responses associated with Mycobacterium bovis BCG vaccination.
Enzyme activities of six different dehydrogenases in Ehrlich ascites cells measured by flow cytometry.
Enzyme histochemical studies on transplantable pancreatic adenocarcinomas in Syrian golden hamsters.
Enzymes involved in l-lactate metabolism in humans.
Epigenetic analysis of HIC1, CASP8, FLIP, TSP1, DCR1, DCR2, DR4, DR5, KvDMR1, H19 and preferential 11p15.5 maternal-allele loss in von Hippel-Lindau and sporadic phaeochromocytomas.
Epigenetic Mutation of the Succinate Dehydrogenase C Promoter in a Patient With Two Paragangliomas.
Epigenetics of pheochromocytoma and paraganglioma.
Epirubicin is equivalent to adriamycin in vitro against many cancer cells but more effective against gastric cancer cells.
Establishment of Patient-derived Succinate Dehydrogenase-deficient Gastrointestinal Stromal Tumor Models For Predicting Therapeutic Response.
Etiopathogenesis and clinical presentation of carotid body tumors.
Evolving concepts in pheochromocytoma and paraganglioma.
Exploring the association of succinate dehydrogenase complex mutations with lymphoid malignancies.
Exploring the link between tumor metabolism and succinate dehydrogenase deficiency: a 18 F-FDOPA PET/CT study in head and neck paragangliomas.
Expression of glutathione S-transferase-pi and sensitivity of human gastric cancer cells to cisplatin.
Expression of IGF-1 receptor in KIT/PDGF receptor-? wild-type gastrointestinal stromal tumors with succinate dehydrogenase complex dysfunction.
Expression of P-glycoprotein influences resistance against anthracyclines in clinical gastric carcinomas.
Expression of tumour necrosis factor alpha and accumulation of fibronectin in coronary artery restenotic lesions retrieved by atherectomy.
Expression of type 2 hexokinase and mitochondria-related genes in gastric carcinoma tissues and cell lines.
Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene.
FDG PET-CT imaging in head and neck paragangliomas: a center experience.
FDOPA Patterns in Adrenal Glands: A Pictorial Essay.
Fisetin modulates mitochondrial enzymes and apoptotic signals in benzo(a)pyrene-induced lung cancer.
Flow-cytometric determination of dehydrogenase activities in primary human gastrointestinal tumor cell lines.
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.
Fumarate hydratase in cancer: A multifaceted tumour suppressor.
Fumarate Metabolic Signature for the Detection of Reed Syndrome in Humans.
Functional Cardiac Paraganglioma Associated with a Rare SDHC Mutation.
Functional consequences of a SDHB gene mutation in an apparently sporadic pheochromocytoma.
Functional consequences of succinate dehydrogenase mutations.
Gain of TP53 Mutation in Imatinib-treated SDH-Deficient Gastrointestinal Stromal Tumor and Clinical Utilization of Targeted Next-generation Sequencing Panel for Therapeutic Decision Support.
Gastrointestinal stromal tumors.
Gastrointestinal stromal tumour in succinate dehydrogenase subunit B mutation-associated familial phaeochromocytoma/paraganglioma.
Gastrointestinal stromal tumour.
Gastrointestinal stromal tumours: from KIT to succinate dehydrogenase.
GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation.
Gene Expression Landscape of SDH-Deficient Gastrointestinal Stromal Tumors.
Genetic alterations in Krebs cycle and its impact on cancer pathogenesis.
Genetic testing for pheochromocytoma and paraganglioma: SDHx carriers' experiences.
Genetic testing for pheochromocytoma-associated syndromes.
Genetic testing in pheochromocytoma: increasing importance for clinical decision making.
Genetically-defined metabolic reprogramming in cancer.
Genetics and molecular pathogenesis of pheochromocytoma and paraganglioma.
Genetics of gigantism and acromegaly.
Genetics of phaeochromocytoma.
Genome-wide Analyses Identifies MEN1 and MAX Mutations and a Neuroendocrine-like Molecular Heterogeneity in Quadruple WT GIST.
GENOMIC IMPRINTING AT A BOUNDARY ELEMENT FLANKING THE SDHD LOCUS.
Germ-line mutations in nonsyndromic pheochromocytoma.
Germline SDHA mutations in children and adults with cancer.
Germline SUCLG2 Variants in Patients with Pheochromocytoma and Paraganglioma.
Glucose levels and succinate and lactate dehydrogenase activity in EMT6/Ro tumor spheroids.
Good survival outcome of metastatic SDH-deficient gastrointestinal stromal tumors harboring SDHA mutations.
Guaiazulene derivative 1,2,3,4-tetrahydroazuleno[1,2-b] tropone reduces the production of ATP by inhibiting electron transfer complex II.
Head and Neck Paraganglioma Atypically Carrying a Succinate Dehydrogenase Subunit B Mutation (L157X).
Head and neck paragangliomas: A two-decade institutional experience and algorithm for management.
Hepatic mitochondrial enzyme activity and serum amino acid composition in rats treated with tumor necrosis factor.
Hepatocytes Determine the Hypoxic Microenvironment and Radiosensitivity of Colorectal Cancer Cells Through Production of Nitric Oxide That Targets Mitochondrial Respiration.
Hereditary Paraganglioma in an Omani Family.
Hereditary paraganglioma targets diverse paraganglia.
Hereditary paragangliomas.
Hereditary syndromes with associated renal neoplasia: a practical guide to histologic recognition in renal tumor resection specimens.
High activity of mitochondrial glycerol phosphate dehydrogenase in insulinomas and carcinoid and other tumors of the amine precursor uptake decarboxylation system.
High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: implications for genetic testing.
High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma.
Histochemical demonstration of succinic dehydrogenase in ascites tumor cells.
Histochemical studies of succinic dehydrogenase by means of tetrazolium in rat liver tumors induced by p-dimethylaminoazobenzene.
Histoenzymatic studies on the behavior of succinic acid dehydrogenase, NADH2 tetrazolium reductase, ATP-ase and alkaline phosphatase in cancer of the uterine cervix in women.
Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo.
Honokiol Bis-Dichloroacetate Is a Selective Allosteric Inhibitor of the Mitochondrial Chaperone TRAP1.
Hormone dependency of rat mammary carcinoma--a comparison of two assay systems.
How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models.
Human hepatocellular carcinoma sensitivity to antitumor drugs assayed using the succinate dehydrogenase inhibition test.
Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue.
Hypoxia Signaling and Circadian Disruption in and by Pheochromocytoma.
Identification of a 4.9-kilo base-pair Alu-mediated founder SDHD deletion in two extended paraganglioma families from Austria.
Identification of novel SDHD mutations in patients with phaeochromocytoma and/or paraganglioma.
Immunizations with IFNgamma secreting tumor cells can eliminate fully established and invasive rat gliomas.
Immunohistochemical Characterization of Fumarate Hydratase (FH) and Succinate Dehydrogenase (SDH) in Cutaneous Leiomyomas for Detection of Familial Cancer Syndromes.
Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation.
Impaired mitochondrial protein synthesis in head and neck squamous cell carcinoma.
Implications of SDHB genetic testing in patients with sporadic pheochromocytoma.
In vitro sensitivity of various human tumors to 1-beta-D-arabinofuranosylcytosine and N4-behenoyl-1-beta-D-arabinofuranosylcytosine.
In vitro succinate dehydrogenase chemosensitivity of gastric carcinoma--relationship to DNA content.
In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDHx Mutations in Paraganglioma.
Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors.
Inborn errors of complex II--unusual human mitochondrial diseases.
Incidence of succinate dehydrogenase and fumarate hydratase-deficient renal cell carcinoma based on immunohistochemical screening with SDHA/SDHB and FH/2SC.
Incomplete penetrance of a novel SDHD variation causing familial head and neck paraganglioma.
Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability.
Increased SSTR2A and SSTR3 expression in succinate dehydrogenase-deficient pheochromocytomas and paragangliomas.
Increased urinary dopamine excretion in association with bilateral carotid body tumours - clinical, biochemical and genetic findings.
Inflammation Associated Pancreatic Tumorigenesis: Upregulation of Succinate Dehydrogenase (Subunit B) Reduces Cell Growth of Pancreatic Ductal Epithelial Cells.
Inhibition of ?-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.
Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by ?-tocopheryl succinate.
Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells.
Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophages.
Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death.
Initial work-up and long-term follow-up in patients with phaeochromocytomas and paragangliomas.
Intraepidermal pilar epithelioma: a new dermatopathologic interpretation of a skin tumor.
Intragenic mutations in thyroid cancer.
Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer?
KIT mutation in a naïve succinate dehydrogenase-deficient gastric GIST.
Krebs Cycle Metabolite Profiling for Identification and Stratification of Pheochromocytomas/Paragangliomas due to Succinate Dehydrogenase Deficiency.
Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair.
L157X nonsense mutation of the succinate dehydrogenase subunit B gene in a Japanese patient with right paraaortic paraganglioma.
Laparoscopic gastrectomy with lymph node dissection for the treatment of remnant stomach gastrointestinal stromal tumors in incomplete-type Carney's triad: a case report.
Large Retroperitoneal Paraganglioma Associated with Germline Mutation of the Succinate Dehydrogenase Gene.
LF15-0195 generates tolerogenic dendritic cells by suppression of NF-kappaB signaling through inhibition of IKK activity.
Li-Fraumeni Syndrome and p53 in 2015: Celebrating their Silver Anniversary.
Longest survive by the combination for radiation-therapy and resection in patient with metastatic spinal paragangliomas from primary-neck lesion with succinate dehydrogenase subunit B (SDHB) mutation.
Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma.
Loss of SDHA expression identifies SDHA mutations in succinate dehydrogenase-deficient gastrointestinal stromal tumors.
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.
Loss of SDHB protein expression by immunohistochemistry distinguishes pulmonary chondromas from hamartomas.
Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism.
Loss of succinate dehydrogenase subunit B (SDHB) expression is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours: a comprehensive genotype-phenotype correlation study.
Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.
Low penetrance of a SDHB mutation in a large Dutch paraganglioma family.
Malignant pheochromocytomas and paragangliomas - The importance of a multidisciplinary approach.
Malignant pheochromocytomas/paragangliomas harbor mutations in transport and cell adhesion genes.
Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II.
Maternal obesity increases offspring's mammary cancer recurrence and impairs tumor immune response.
MDCT features of succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumours.
Measurement of DPD and TS transcripts aimed to predict clinical benefit from fluoropyrimidines: confirmation of the trend in Russian colorectal cancer series and caution regarding the gene referees.
Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma.
Metabolic Enzymes in Sarcomagenesis: Progress Toward Biology and Therapy.
Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and paraganglioma.
Metabolic subtyping of pheochromocytoma and paraganglioma by 18F-FDG pharmacokinetics using dynamic PET/CT scanning.
Metabolome-guided genomics to identify pathogenic variants in isocitrate dehydrogenase, fumarate hydratase, and succinate dehydrogenase genes in pheochromocytoma and paraganglioma.
Metabolomics in the Diagnosis of Pheochromocytoma and Paraganglioma.
Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas.
Metallothionein expression is correlated with cisplatin resistance in transitional cell carcinoma of the urinary tract.
Metastatic pheochromocytoma and paraganglioma.
Methylation of the p16INK4A promoter is associated with malignant behavior in abdominal extra-adrenal paragangliomas but not pheochromocytomas.
MicroRNAs and Gastrointestinal Stromal Tumor.
Miltefosine efficiently eliminates Leishmania major amastigotes from infected murine dendritic cells without altering their immune functions.
Mitochondria in cancer: at the crossroads of life and death.
MITOCHONDRIA: Succinate dehydrogenase subunit B-associated phaeochromocytoma and paraganglioma.
Mitochondrial and nuclear genes of mitochondrial components in cancer.
Mitochondrial complex I is deficient in renal oncocytomas.
Mitochondrial complex II and genomic imprinting in inheritance of paraganglioma tumors.
Mitochondrial Deficiencies in the Predisposition to Paraganglioma.
Mitochondrial disorders: clinical presentation and diagnostic dilemmas.
Mitochondrial dysfunctions in cancer: Genetic defects and oncogenic signaling impinging on TCA cycle activity.
Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species.
Mitochondrial fumarate reductase as a target of chemotherapy: From parasites to cancer cells.
Mitochondrial mutations in cancer.
Mitochondrial reactive oxygen species generation by the SDHC V69E mutation causes low birth weight and neonatal growth retardation.
Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions.
Mitochondrial tumour suppressors: a genetic and biochemical update.
Mitophagy contributes to alpha-tocopheryl succinate toxicity in GSNOR-deficient hepatocellular carcinoma.
Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor.
Modulating mammary tumor growth, metastasis and immunosuppression by siRNA-induced MIF reduction in tumor microenvironment.
Modulation of genes related to the recruitment of immune cells in the digestive tract of trout experimentally infected with infectious pancreatic necrosis virus (IPNV) or orally vaccinated.
Molecular alterations and expression of succinate dehydrogenase complex in wild-type KIT/PDGFRA/BRAF gastrointestinal stromal tumors.
Molecular characterization of novel germline deletions affecting SDHD and SDHC in pheochromocytoma and paraganglioma patients.
Molecular genetics and immunohistochemistry characterization of uncommon and recently described renal cell carcinomas.
Molecular Subtypes of KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Gastrointestinal Stromal Tumor Clinic.
Mouse Melanoma Cell Migration is Dependent on Production of Reactive Oxygen Species under Normoxia Condition.
Multifocal Renal Cell Carcinomas With Somatic IDH2 Mutation: Report of a Previously Undescribed Neoplasm.
Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma.
Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability.
Mutational spectrum and classification of novel mutations in patients with metastatic gastrointestinal stromal tumours.
Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas.
Mutations of the metabolic genes IDH1, IDH2, and SDHAF2 are not major determinants of the pseudohypoxic phenotype of sporadic pheochromocytomas and paragangliomas.
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
Myc-mediated transcriptional regulation of the mitochondrial chaperone TRAP1 controls primary and metastatic tumor growth.
Neck paraganglioma and follicular lymphoma: a case report.
New HIF2? inhibitors: potential implications as therapeutics for advanced pheochromocytomas and paragangliomas.
New insights into the genetics of familial chromaffin cell tumors.
No evidence for promoter region methylation of the succinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer.
No KRAS mutations found in gastrointestinal stromal tumors (GISTs): molecular genetic study of 514 cases.
Non-immunologically-mediated cytotoxicity of Lactobacillus casei and its derivative peptidoglycan against tumor cell lines.
Non-pheochromocytoma/paraganglioma tumors in patients with succinate dehydrogenase-related pheochromocytoma-paraganglioma syndromes: a clinicopathologic and molecular analysis.
On the association of succinate dehydrogenase mutations with hereditary paraganglioma.
Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation.
Oncometabolites in cancer aggressiveness and tumour repopulation.
Oncometabolites suppress DNA repair by disrupting local chromatin signalling.
Oncometabolites: tailoring our genes.
Over expression of CDK4 and MDM2 in a patient with recurrent ALK-negative mediastinal inflammatory myofibroblastic tumor: A case report.
Over-representation of the G12S polymorphism of the SDHD gene in patients with MEN2A syndrome.
Oxidative Phosphorylation System in Gastric Carcinomas and Gastritis.
Oxidoreductase activities in normal rat liver, tumor-bearing rat liver, and hepatoma HC-252.
Oxygen concentration controls epigenetic effects in models of familial paraganglioma.
p-Cymene Complexes of Ruthenium(II) as Antitumor Agents.
Paraganglioma and pheochromocytoma upon maternal transmission of SDHD mutations.
Paraganglioma of the carotid body and intrapericardium.
Paraganglioma of the Carotid Body: Treatment Strategy and SDH-gene Mutations.
Paraganglioma of the organ of Zuckerkandl associated with a somatic HIF2? mutation: A case report.
Paraganglioma of the Vagina Associated With Germline SDHB Mutation: Report of a Case With Review of the Literature.
Paragangliomas: update on differential diagnostic considerations, composite tumors, and recent genetic developments.
Pathologic grading for predicting metastasis in phaeochromocytoma and paraganglioma.
Pathological changes on human breast cancer specimens ablated in vitro with high-intensity focused ultrasound.
Peptide receptor radionuclide therapy in patients with metastatic progressive pheochromocytoma and paraganglioma: long-term toxicity, efficacy and prognostic biomarker data of phase II clinical trials.
Phaeochromocytoma in children.
Phaeochromocytoma.
Phaeochromocytoma: a catecholamine and oxidative stress disorder.
Phenotype variability of neural crest derived tumours in six Italian families segregating the same founder SDHD mutation Q109X.
Pheochromocytoma and paraganglioma genetic testing: Psychological impact.
Pheochromocytoma and Paraganglioma in Children and Adolescents: Experience of the French Society of Pediatric Oncology (SFCE).
Pheochromocytoma and paraganglioma syndromes: genetics and management update.
Pheochromocytoma as a catecholamine producing tumor: implications for clinical practice.
Pheochromocytoma in von Hippel-Lindau disease and neurofibromatosis type 1.
Pheochromocytoma: an update on genetics and management.
Pheochromocytoma: Diagnostic and Therapeutic Update.
Pheochromocytoma: the expanding genetic differential diagnosis.
Pheochromocytomas and Paragangliomas: An Update on Recent Molecular Genetic Advances and Criteria for Malignancy.
Pheochromocytomas: From Genetic Diversity to New Paradigms.
Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in human and mice.
Pituitary gigantism: update on molecular biology and management.
Plasma methoxytyramine: A novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status.
Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST].
Prediction of doxorubicin resistance in gastrointestinal cancer by P-glycoprotein staining.
Preferential MGMT methylation could predispose a subset of KIT/PDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents.
Primary fibroblast co-culture stimulates growth and metabolism in Sdhb-impaired mouse pheochromocytoma MTT cells.
Primary Renal Paragangliomas and Renal Neoplasia Associated with Pheochromocytoma/Paraganglioma: Analysis of von Hippel-Lindau (VHL), Succinate Dehydrogenase (SDHX) and Transmembrane Protein 127 (TMEM127).
Prospective comparison of (68)Ga-DOTATATE and (18)F-FDOPA PET/CT in patients with various pheochromocytomas and paragangliomas with emphasis on sporadic cases.
Protective effects of N(2)?L?alanyl?L?glutamine mediated by the JAK2/STAT3 signaling pathway on myocardial ischemia reperfusion.
Rapid, quantitative microassay for the monokine respiration inhibitory factor.
Rare insights into cancer biology.
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1.
Recent advances in the diagnosis and treatment of pheochromocytoma.
Recent advances in the genetics of phaeochromocytoma and functional paraganglioma.
Recurrent epimutation of SDHC in gastrointestinal stromal tumors.
Recurrent familial malignant carotid body tumour presenting with lymph node metastasis: case report, and review of diagnosis and management of familial carotid body tumours.
Regulation of HLA-DR antigen in monocytes from colorectal cancer patients by in vitro treatment with human recombinant interferon-gamma.
Regulation of succinate dehydrogenase and role of succinate in cancer.
Regulation of succinate-ubiquinone reductase and fumarate reductase activities in human complex II by phosphorylation of its flavoprotein subunit.
Renal cell carcinoma in tuberous sclerosis complex.
Renal Cell Carcinoma with Angioleiomyoma-Like Stroma and Clear Cell Papillary Renal Cell Carcinoma: Exploring SDHB Protein Immunohistochemistry and the Relationship to Tuberous Sclerosis Complex.
Renal cell carcinoma with TFE3 translocation and succinate dehydrogenase B mutation.
Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration.
Research Resource: Transcriptional Profiling Reveals Different Pseudohypoxic Signatures in SDHB and VHL-Related Pheochromocytomas.
Respiratory chain complex II as general sensor for apoptosis.
Revisiting the TCA cycle: signaling to tumor formation.
Risk Stratification on Pheochromocytoma and Paraganglioma from Laboratory and Clinical Medicine.
Role of mitochondrial dysfunction in cancer progression.
Role of mitochondrial mutations in cancer.
Role of natural interferon-producing cells and T lymphocytes in porcine monocyte-derived dendritic cell maturation.
Role of oxidative stress from mitochondria on aging and cancer.
Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors.
Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate.
ROS-triggered and regenerating anticancer nanosystem: an effective strategy to subdue tumor's multidrug resistance.
Screening for Pheochromocytomas and Paragangliomas.
SDH mutations in patients affected by paraganglioma syndromes: a personal experience.
SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma-paraganglioma syndromes.
SDH5 Depletion Enhances Radiosensitivity by Regulating p53: A New Method for Noninvasive Prediction of Radiotherapy Response.
SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors.
SDHB and SDHA Immunohistochemistry in Canine Pheochromocytomas.
SDHB deficiency promotes TGF?-mediated invasion and metastasis of colorectal cancer through transcriptional repression complex SNAIL1-SMAD3/4.
SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery.
SDHC epi-mutation testing in gastrointestinal stromal tumours and related tumours in clinical practice.
SDHC Methylation Pattern in Patients With Carney Triad.
SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology.
SDHD-related chromaffin tumours: disease localisation to genetic dysfunction.
Secretory, enzymatic, and morphological characterization of rat pancreatic endocrine tumours induced by streptozotocin and nicotinamide.
Sensitivity to heat and radiation of human rectal malignant tissues in vitro.
Sensitivity to six antitumor drugs differs between primary and metastatic liver cancers.
Signalling pathways in succinate dehydrogenase B-associated renal carcinoma.
Significance of Alpha-inhibin Expression in Pheochromocytomas and Paragangliomas.
Simultaneous KIT mutation and succinate dehydrogenase (SDH) deficiency in a patient with a gastrointestinal stromal tumour and Carney-Stratakis syndrome: a case report.
SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism.
Somatic SDHA mutations in paragangliomas in siblings: Case report of 2 cases.
Staining of bladder tumor cell dehydrogenase.
Streptozotocin-induced diabetic cardiomyopathy in rats: ameliorative effect of PIPERINE via Bcl2, Bax/Bcl2, and caspase-3 pathways.
Structural and biochemical changes in mitochondria after cisplatin treatment of Dalton's lymphoma-bearing mice.
Structural and functional consequences of succinate dehydrogenase subunit B mutations.
Studies of succinate dehydrogenase inhibition (SDI) test with cisplatin encapsulated liposome against cancer cells.
Subclinical phaeochromocytoma.
Succinate dehydrogenase (SDH) and mitochondrial driven neoplasia.
Succinate Dehydrogenase (SDH) D Subunit (SDHD) Inactivation in a Growth-Hormone-Producing Pituitary Tumor: A New Association for SDH?
Succinate dehydrogenase (SDH)-deficient neoplasia.
Succinate Dehydrogenase (SDH)-deficient pancreatic neuroendocrine tumor expands the SDH-related tumor spectrum.
Succinate Dehydrogenase (SDH)-deficient Renal Carcinoma: A Morphologically Distinct Entity: A Clinicopathologic Series of 36 Tumors From 27 Patients.
Succinate dehydrogenase activity in tissues of Swiss mice bearing Schwartz leukemic tumour.
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.
Succinate dehydrogenase and human diseases: new insights into a well-known enzyme.
Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases.
Succinate dehydrogenase B subunit immunohistochemical expression predicts aggressiveness in well differentiated neuroendocrine tumors of the ileum.
Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors.
Succinate dehydrogenase B: a new prognostic biomarker in clear cell renal cell carcinoma.
Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function.
Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors.
Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis.
Succinate dehydrogenase deficiency is rare in pituitary adenomas.
Succinate dehydrogenase deficient gastrointestinal stromal tumor in a three month old boy with a fatal clinical course: a case report and review of literature.
Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) - a review.
Succinate dehydrogenase inhibition test for evaluating head and neck tumors.
Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer.
Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics.
Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor.
Succinate Dehydrogenase Subunit B (SDHB) Is Expressed in Neurofibromatosis 1-Associated Gastrointestinal Stromal Tumors (Gists): Implications for the SDHB Expression Based Classification of Gists.
Succinate dehydrogenase subunit B inhibits the AMPK-HIF-1¿ pathway in human ovarian cancer in vitro.
Succinate Dehydrogenase Subunit B Mutations Modify Human Neuroblastoma Cell Metabolism and Proliferation.
Succinate dehydrogenase subunit D and succinate dehydrogenase subunit B mutation analysis in canine phaeochromocytoma and paraganglioma.
Succinate dehydrogenase-deficient gastrointestinal stromal tumor of stomach diagnosed by endoscopic ultrasound-guided fine-needle biopsy: Report of a distinct subtype in cytology.
Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumors.
Succinate dehydrogenase-deficient GISTs are characterized by IGF1R overexpression.
Succinate dehydrogenase-deficient GISTs: a clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GISTs with predilection to young age.
Succinate Dehydrogenase-Deficient Renal Cancer Featuring Fructose-1,6-Biphosphatase Loss, Pyruvate Kinase M2 Overexpression, and SWI/SNF Chromatin Remodeling Complex Aberrations: A Rare Case Report.
Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma.
Succinate in the cancer-immune cycle.
Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma.
Succinate Pathway in Head and Neck Squamous Cell Carcinoma: Potential as a Diagnostic and Prognostic Marker.
Succinate: a new epigenetic hacker.
Succinate: An initiator in tumorigenesis and progression.
Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-?B Pathways.
Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.
Surgical management of adrenal tumors.
Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion.
Synchronous adrenocortical neoplasms, paragangliomas, and pheochromocytomas: syndromic considerations regarding an unusual constellation of endocrine tumors.
Synergism of cytotoxicity between cis-diaminedichloro-platinum-(ii) and cis-diamine(1,1-cyclobutanedicarboxylate)-platinum-(ii).
Synergistic antioxidant capacities of vanillin and chitosan nanoparticles against reactive oxygen species, hepatotoxicity, and genotoxicity induced by aging in male Wistar rats.
Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction.
Targeting cancer metabolism.
Targeting Cyclooxygenase-2 in Pheochromocytoma and Paraganglioma: Focus on Genetic Background.
Targeting metabolic pathways for head and neck cancers therapeutics.
TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State.
TGFbeta is responsible for skin tumour infiltration by macrophages enabling the tumours to escape immune destruction.
THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.
The activity of succinic dehydrogenase in glial tumors.
The ATP assay is more sensitive than the succinate dehydrogenase inhibition test for predicting cell viability.
The biological significance of cancer: mitochondria as a cause of cancer and the inhibition of glycolysis with citrate as a cancer treatment.
The diagnosis and management of malignant phaeochromocytoma and paraganglioma.
The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency.
The functional roles of TCA cycle metabolites in cancer.
The genetic basis of isolated mitochondrial complex II deficiency.
The genetic landscape of gastrointestinal stromal tumor lacking KIT and PDGFRA mutations.
The Impact Of Succinate Dehydrogenase Gene (SDH) Mutations In Renal Cell Carcinoma (RCC): A Systematic Review.
The microtitre succinate dehydrogenase inhibition test for chemosensitivity of human tumour cells.
The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.
The phenotype of SDHB germline mutation carriers: a nationwide study.
The predictability of clinical antitumor effects using two distinctive in vitro chemosensitivity tests: an analysis of true positive cases.
The Role of 68Ga-DOTA-Octreotate PET/CT in Follow-Up of SDH-Associated Pheochromocytoma and Paraganglioma.
The role of autophagy in asparaginase-induced immune suppression of macrophages.
The role of complex II in disease.
The Role of Immunohistochemistry and Molecular Analysis of Succinate Dehydrogenase in the Diagnosis of Endocrine and Non-Endocrine Tumors and Related Syndromes.
The role of metabolic enzymes in mesenchymal tumors and tumor syndromes: genetics, pathology, and molecular mechanisms.
The role of the electron transport SDHC gene on lifespan and cancer.
The stability and activity of respiratory Complex II is cardiolipin-dependent.
The standard diagnosis, treatment, and follow-up of gastrointestinal stromal tumors based on guidelines.
The succinate dehydrogenase inhibition test for evaluating biopsy specimens and resected tumors of advanced gastric cancer.
The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction.
The use of tetranitro-blue tetrazolium for the cytochemical localization of succinic dehydrogenase. Cytochemical and cytological studies of sarcoma 37 ascites tumor cells.
Therapeutic effect of tamoxifen and energy-modulating vitamins on carbohydrate-metabolizing enzymes in breast cancer.
Three subtypes of poroid neoplasia in a single lesion: eccrine poroma, hidroacanthoma simplex, and dermal duct tumor. Histologic, histochemical, and ultrastructural findings.
Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations.
Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas.
Transcriptome sequencing identifies ETV6-NTRK3 as a gene fusion involved in GIST.
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
Transketolase regulates the metabolic switch to control breast cancer cell metastasis via the alpha-ketoglutarate signaling pathway.
Translating in vivo metabolomic analysis of succinate dehydrogenase deficient tumours into clinical utility.
Treatment responses to antiangiogenetic therapy and chemotherapy in nonsecreting paraganglioma (PGL4) of urinary bladder with SDHB mutation: A case report.
Tumor inhibition and hematological improvements by dopamine analog 3,4-dihydroxybenzylamine in mice bearing transplantable carcinoma.
Tumor necrosis factor induces activation of mitochondrial succinate dehydrogenase.
Tumor tissue is more sensitive to mitomycin C, carboquone, and aclacinomycin A than is adjacent normal tissue in vitro.
Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes
Tumour Risks and Genotype-Phenotype-Proteotype Analysis in 358 Patients with Germline Mutations in SDHB and SDHD.
Turn up the cellular power generator with vitamin E analogue formulation.
UPDATE ON THE CLINICOPATHOLOGY OF PITUITARY ADENOMAS.
Upregulation of SDHA inhibited proliferation, migration, and invasion of clear cell renal cell carcinoma cells via inactivation of the Wnt/?-catenin pathway.
Upregulation of ZNF148 in SDHB-deficient gastrointestinal stromal tumor potentiates Forkhead box M1-mediated transcription and promotes tumor cell invasion.
Urinary Bladder Paragangliomas: Analysis of Succinate Dehydrogenase and Outcome.
Use of the succinate dehydrogenase inhibition test in assessing the heat sensitivity of tumor cells.
USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability.
Utility of immunohistochemical investigation of SDHB and molecular genetic analysis of SDH genes in the differential diagnosis of mesenchymal tumors of GIT.
Utility of the succinate: Fumarate ratio for assessing SDH dysfunction in different tumor types.
Viral and host factors in the prediction of response to interferon-alpha therapy in chronic hepatitis C after long-term follow-up.
Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?
Yeast model for evaluating the pathogenic significance of SDHB, SDHC and SDHD mutations in PHEO-PGL syndrome.
[A 47-year-old patient with paroxysmal arterial hypertension and gastric tumors].
[A chronobiological analysis of the lymphocyte dehydrogenase activity in the peripheral blood of rats with Walker 256 carcinosarcoma]
[Achievements of the COMETE program in the genetics of pheochromocytoma]
[Action of thymic lipid extract B on adenosine triphosphatase and succinate dehydrogenase of the liver of rats with Guerin tumors]
[Changes in lymphocytes under influence of oxidative substrates].
[Changes of hepatic glycogen, lactic acid, glucose-6-phosphatase activity and succinate dehydrogenase in the sourse of tumor development under the influence of B thymus extract]
[Chemosensitivity testing of anticancer agents in head and neck tumors. I: Comparison between head and neck squamous cell cancers and thyroid cancers]
[Clinical studies of in vitro chemosensitivity test evaluated by ATP assay of gastrointestinal cancer]
[Comparison between clinical response and in vitro chemosensitivity of solid tumors in the succinic dehydrogenase inhibition test]
[Comparison between the succinate dehydrogenase inhibition test and ATP assay for in vitro chemosensitivity testing]
[Comparison of succinic dehydrogenase inhibition test with adenosine triphosphate inhibition assay for human solid tumors as in vitro chemosensitivity tests]
[Demonstration of succinate dehydrogenase activity in ascites tumor cells using fluorescent tetrazolium salts]
[Distribution of succinate dehydrogenase in tumors of the astrocyte series]
[Effect of chlorpromazine and dexedrine on the succinate dehydrogenase and lactate dehydrogenase activity of tumors, spleen and liver of normal and tumor-bearing rats. II]
[Effect of the antibiotic cruzin on succinic dehydrogenase and cytochrome oxidase of tumor tissue.]
[Effects of plant polysaccharide paliustran on the growth of human tumor transplants in athymic mice]
[Endocrine surgery for neck paraganglioma : Operation, radiation therapy or wait and scan?]
[Enzyme cytochemistry and morphometric study of the effects of macrophages on A549 pulmonary alveolar cell carcinoma cell line]
[Evaluation of the succinate dehydrogenase inhibition (SDI) method in local chemotherapy of cancer]
[Expression of succinate dehydrogenase subunit protein in succinate dehydrogenase-deficient gastrointestinal stromal tumors].
[Fluorescent formazans in flow cytometry. Studies of their oxygen sensitivity]
[Fundamental study of subrenal capsule assay by measuring specific activity of succinate dehydrogenase]
[Head and neck paragangliomas: revision of 89 cases in 73 patients]
[Hereditary and non-hereditary syndromic gastointestinal stromal tumours].
[Hereditary head and neck tumors].
[Histochemical and ultrastructural investigations on organ culture of malignant tumors (author's transl)]
[Histochemical investigations on human bladder cancer (author's transl)]
[Histochemistry of succinodehydrogenase in embryonal cells and cell of malignant tumors.]
[Hypertension, catecholamine hypersecretion and potential for metastasis: recent progress in the pathophysiology and genetics of pheochromocytoma and paraganglioma].
[In vitro chemosensitivity of various human tumors evaluated by the SDI (succinate dehydrogenase inhibition) test]
[In vitro chemosensitivity of various human tumors evaluated by the succinate dehydrogenase inhibition (SDI) test (2)]
[In vitro chemosensitivity test using collagen gel matrix for human gastric carcinomas]
[In vitro chemosensitivity test: succinate dehydrogenase inhibition (SDI) test]
[In vitro thermosensitivity of various human tumors evaluated using the SDI (succinate dehydrogenase inhibition) test]
[In vitro tumor sensitivity tests to chemotherapeutic agents by the suppression of dehydrogenase activity]
[Influence of cancer extracts on succinic dehydrogenase activity of rat tissue.]
[Microspectrophotometric study of the content of various metabolites in cervical cancer]
[Oxidoreductase activity in the cells of stomach cancer]
[Paraganglioma in the area of the head and neck. A review of molecular genetic research]
[Research advances in molecular biology of carotid body tumor.]
[SDI test using MTT for the evaluation of drug sensitivities of gastrointestinal cancer cells]
[Secondary hepatic resections in a case of sigmoid colon cancer with multiple liver metastasis (H3) after successful continuous hepatic artery infusion chemotherapy oriented by in vitro chemosensitivity test]
[Significance of succinate dehydrogenase complex variation in tumor pathological diagnosis].
[Succinate dehydrogenase activity in the cells of ascites tumors. Effect of radiations]
[Succinate dehydrogenase deficient gastrointestinal stromal tumor: a clinicopathologic analysis of eight cases].
[Succinic dehydrogenase activity in the uterine cervix in physiological and pathological conditions, with special reference to neoplasms.]
[SUCCINIC DEHYDROGENASE CYTOENZYMOLOGY IN BROWN-PEARCE TUMOR CELLS.]
[Sulfhydryl group levels and the succinate dehydrogenase activity in peripheral blood lymphocytes in patients with cancer of the stomach]
[The sensitivity of 1,000 human tumors to antitumor drugs using the succinate dehydrogenase inhibition (SDI) test]
[The state of the mitochondrial energy-supplying system of blood leukocytes in the dynamics of guerin's carcinoma growth under the low-level irradiation conditions.]
Neoplasms, Glandular and Epithelial
Mapping of Succinate Dehydrogenase Losses in 2258 Epithelial Neoplasms.
Renal cell carcinoma in tuberous sclerosis complex.
Neoplasms, Neuroepithelial
Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.
Neoplasms, Second Primary
Neck paraganglioma and follicular lymphoma: a case report.
Neoplastic Syndromes, Hereditary
Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair.
Nephritis
Characterization of interstitial nephritis in pigs with naturally occurring postweaning multisystemic wasting syndrome.
[On the effect of cortisone on the activity of succinic dehydrogenase in the kidneys in experimental cytotoxic nephritis.]
[Phosphatase and succinate dehydrogenase activity in the leukocytes in chronic pyelonephritis and chronic nephritis]
[Succinate dehydrogenase isoenzymes in kidney tissue normally and in experimental corrosive sublimate nephritis]
Nephrosis
Effect of nephrosis on renal Qo2 and histochemical appearance of cytochrome oxidase and succinic dehydrogenase.
Nervous System Diseases
Kinetic solvent viscosity effects reveal a protein isomerization in the reductive half-reaction of Neurospora crassa class II nitronate monooxygenase.
Nervous System Neoplasms
Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?
Neurilemmoma
Alterations of oxidative phosphorylation in meningiomas and peripheral nerve sheath tumors.
Diagnostic Role of Diffusion-Weighted and Dynamic Contrast-Enhanced Perfusion MR Imaging in Paragangliomas and Schwannomas in the Head and Neck.
Utility of immunohistochemical investigation of SDHB and molecular genetic analysis of SDH genes in the differential diagnosis of mesenchymal tumors of GIT.
Neuroblastoma
Comparative in vitro effects of sodium arsenite and sodium arsenate on neuroblastoma cells.
Differential production of superoxide by neuronal mitochondria.
Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitroproprionic acid in SK-N-SH human neuroblastoma cells.
Failure of MIBG scan to detect metastases in SDHB-mutated pediatric metastatic pheochromocytoma.
Impaired mitochondrial function results in increased tissue transglutaminase activity in situ.
Induction of Expression of p75 Neurotrophin Receptor Intracellular Domain Does Not Induce Expression or Enhance Activity of Mitochondrial Complex II.
Role of microenvironment on neuroblastoma SK-N-AS SDHB-silenced cell metabolism and function.
Succinate Dehydrogenase Subunit B Mutations Modify Human Neuroblastoma Cell Metabolism and Proliferation.
Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity.
Targeting succinate:ubiquinone reductase potentiates the efficacy of anticancer therapy.
Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells.
Neurodegenerative Diseases
A spectrophotometric coupled enzyme assay to measure the activity of succinate dehydrogenase.
Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology.
Deficiency of complex II of the mitochondrial respiratory chain in late-onset optic atrophy and ataxia.
Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors.
Effect of Pesticides on the Aggregation of Mutant Huntingtin Protein.
Hereditary paraganglioma/pheochromocytoma and inherited succinate dehydrogenase deficiency.
Inhibition of mitochondrial complex II in neuronal cells triggers unique pathways culminating in autophagy with implications for neurodegeneration.
Intrastriatal injections of the succinate dehydrogenase inhibitor, malonate, cause a rise in extracellular amino acids that is blocked by MK-801.
Late-onset optic atrophy, ataxia, and myopathy associated with a mutation of a complex II gene.
Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter.
Protection of malonate-induced GABA but not dopamine loss by GABA transporter blockade in rat striatum.
Protein Footprinting via Covalent Protein Painting Reveals Structural Changes of the Proteome in Alzheimer's Disease.
Respiratory chain complex II as general sensor for apoptosis.
Role for dopamine in malonate-induced damage in vivo in striatum and in vitro in mesencephalic cultures.
Striatal degeneration induced by mitochondrial blockade is prevented by biologically delivered NGF.
Succinate dehydrogenase: Prospect for neurodegenerative diseases.
Neuroendocrine Tumors
An unusual succinate dehydrogenase gene mutation C in a case of laryngeal paraganglioma.
Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas.
Early presentation of familial paraganglioma with SDHB mutation in a 13 year old child and its mother.
Li-Fraumeni Syndrome and p53 in 2015: Celebrating their Silver Anniversary.
Loss of succinate dehydrogenase subunit B (SDHB) as a prognostic factor in advanced ileal well-differentiated neuroendocrine tumors.
Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations.
SDH mutations establish a hypermethylator phenotype in paraganglioma.
Succinate Dehydrogenase (SDH)-deficient pancreatic neuroendocrine tumor expands the SDH-related tumor spectrum.
Succinate dehydrogenase B subunit immunohistochemical expression predicts aggressiveness in well differentiated neuroendocrine tumors of the ileum.
UPDATE ON THE CLINICOPATHOLOGY OF PITUITARY ADENOMAS.
Neurofibroma
Alterations of oxidative phosphorylation in meningiomas and peripheral nerve sheath tumors.
Neurofibromatoses
18F-FDG Avidity of Pheochromocytomas and Paragangliomas: A New Molecular Imaging Signature?
Adrenal ganglioneuroma resected for suspicious malignancy: multicenter review of 25 cases and review of the literature.
An update on the genetics of benign pituitary adenomas in children and adolescents.
CHARACTERISTICS AND OUTCOMES OF METASTATIC SDHB AND SPORADIC PHEOCHROMOCYTOMA/PARAGANGLIOMA: AN NATIONAL INSTITUTES OF HEALTH STUDY.
Characteristics of pheochromocytoma in a 4- to 20-year-old population.
Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas.
Epigenetic analysis of HIC1, CASP8, FLIP, TSP1, DCR1, DCR2, DR4, DR5, KvDMR1, H19 and preferential 11p15.5 maternal-allele loss in von Hippel-Lindau and sporadic phaeochromocytomas.
Gastrointestinal stromal tumors.
Gastrointestinal stromal tumors: what do we know now?
Genetic testing in pheochromocytoma: increasing importance for clinical decision making.
Genetics and molecular pathogenesis of pheochromocytoma and paraganglioma.
Genetics of phaeochromocytoma.
Germline c.1A>C heterozygous pathogenic variant in SDHA reported for the first time in a young adult with a gastric gastrointestinal stromal tumour (GIST): a case report.
Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes.
Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST).
Phaeochromocytoma in children.
Phaeochromocytoma.
Pheochromocytoma and paraganglioma syndromes: genetics and management update.
Pheochromocytoma as a catecholamine producing tumor: implications for clinical practice.
Pheochromocytoma: Diagnostic and Therapeutic Update.
Pheochromocytomas and Paragangliomas: An Update on Recent Molecular Genetic Advances and Criteria for Malignancy.
Pheochromocytomas and Paragangliomas: Clinical and Genetic Approaches.
Recent advances in the diagnosis and treatment of pheochromocytoma.
Research Resource: Transcriptional Profiling Reveals Different Pseudohypoxic Signatures in SDHB and VHL-Related Pheochromocytomas.
Screening for genetic causes of hypertension.
SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma-paraganglioma syndromes.
Succinate Dehydrogenase Subunit B (SDHB) Is Expressed in Neurofibromatosis 1-Associated Gastrointestinal Stromal Tumors (Gists): Implications for the SDHB Expression Based Classification of Gists.
Succinate dehydrogenase-deficient GISTs are characterized by IGF1R overexpression.
Surgical management of adrenal tumors.
Synchronous adrenocortical neoplasms, paragangliomas, and pheochromocytomas: syndromic considerations regarding an unusual constellation of endocrine tumors.
[Hereditary and non-hereditary syndromic gastointestinal stromal tumours].
[Molecular mechanism of gastrointestinal stromal tumors and progress in drug research].
Neurofibromatosis 1
18F-FDG Avidity of Pheochromocytomas and Paragangliomas: A New Molecular Imaging Signature?
An update on the genetics of benign pituitary adenomas in children and adolescents.
CHARACTERISTICS AND OUTCOMES OF METASTATIC SDHB AND SPORADIC PHEOCHROMOCYTOMA/PARAGANGLIOMA: AN NATIONAL INSTITUTES OF HEALTH STUDY.
Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas.
Epigenetic analysis of HIC1, CASP8, FLIP, TSP1, DCR1, DCR2, DR4, DR5, KvDMR1, H19 and preferential 11p15.5 maternal-allele loss in von Hippel-Lindau and sporadic phaeochromocytomas.
Gastrointestinal stromal tumors.
Gastrointestinal stromal tumors: what do we know now?
Genetic testing for pheochromocytoma-associated syndromes.
Genetic testing in pheochromocytoma: increasing importance for clinical decision making.
Genetics and molecular pathogenesis of pheochromocytoma and paraganglioma.
Germline c.1A>C heterozygous pathogenic variant in SDHA reported for the first time in a young adult with a gastric gastrointestinal stromal tumour (GIST): a case report.
Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes.
Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST).
Phaeochromocytoma in children.
Phaeochromocytoma.
Pheochromocytoma and paraganglioma syndromes: genetics and management update.
Pheochromocytoma as a catecholamine producing tumor: implications for clinical practice.
Pheochromocytoma: an update on genetics and management.
Pheochromocytoma: Diagnostic and Therapeutic Update.
Pheochromocytomas and Paragangliomas: An Update on Recent Molecular Genetic Advances and Criteria for Malignancy.
Recent advances in the diagnosis and treatment of pheochromocytoma.
Research Resource: Transcriptional Profiling Reveals Different Pseudohypoxic Signatures in SDHB and VHL-Related Pheochromocytomas.
SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma-paraganglioma syndromes.
Succinate dehydrogenase-deficient GISTs are characterized by IGF1R overexpression.
Surgical management of adrenal tumors.
[Molecular mechanism of gastrointestinal stromal tumors and progress in drug research].
Neuroinflammatory Diseases
Identification of Genetic Modifiers of TDP-43: Inflammatory Activation of Astrocytes for Neuroinflammation.
Newcastle Disease
Succinic dehydrogenase activity in HeLa cells infected with Newcastle disease virus.
Non-alcoholic Fatty Liver Disease
Western Diet Decreases the Liver Mitochondrial Oxidative Flux of Succinate: Insight from a Murine NAFLD Model.
Obesity
Adenosine Triphosphate Production of Muscle Mitochondria after Acute Exercise in Lean and Obese Humans.
Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity.
Donepezil Prevents Inhibition of Cerebral Energetic Metabolism Without Altering Behavioral Parameters in Animal Model of Obesity.
Genomic signatures of fine-scale local selection in Atlantic salmon suggest involvement of sexual maturation, energy homeostasis and immune defence-related genes.
Obesity modifies the stoichiometry of mitochondrial proteins in a way that is distinct to the subcellular localization of the mitochondria in skeletal muscle.
Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity.
Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency.
YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.
Obesity, Maternal
Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus.
Obesity, Morbid
Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity.
Occupational Diseases
[Analysis of the lymphocyte population in the cytochemical study of alpha-glycerophosphate and succinate dehydrogenase in patients with occupational diseases]
Olivopontocerebellar Atrophies
Abnormalities of mitochondrial enzymes in hereditary ataxias.
Oophoritis
Chrono- and Immunocorrection of Inflammatory Disorders of Internal Reproductive Organs in Women of Reproductive Age.
Ophthalmoplegia, Chronic Progressive External
Enzyme activity analyses along ragged-red and normal single muscle fibres.
Expression of oxidative phosphorylation genes in muscle cell cultures from patients with mitochondrial myopathies.
Optic Atrophy
Deficiency of complex II of the mitochondrial respiratory chain in late-onset optic atrophy and ataxia.
Inborn errors of complex II--unusual human mitochondrial diseases.
Late-onset optic atrophy, ataxia, and myopathy associated with a mutation of a complex II gene.
Succinate dehydrogenase and human diseases: new insights into a well-known enzyme.
Optic Atrophy, Autosomal Dominant
Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy.
Optic Atrophy, Hereditary, Leber
Compensatory elevation of complex II activity in Leber's hereditary optic neuropathy.
Optic Nerve Diseases
Compensatory elevation of complex II activity in Leber's hereditary optic neuropathy.
Osteosarcoma
2-Methoxyestradiol Affects Mitochondrial Biogenesis Pathway and Succinate Dehydrogenase Complex Flavoprotein Subunit A in Osteosarcoma Cancer Cells.
Antitumor chemosensitivity differs between clinical sarcoma and adenocarcinoma tissues.
[Intra-arterial combination chemotherapy using both regimen selected by chemosensitivity test and caffeine to increase effect for osteosarcoma in extremity]
Ototoxicity
Ototoxicity of carboplatin in guinea pigs.
Out-of-Hospital Cardiac Arrest
Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest.
Ovarian Neoplasms
Inhibition of succinate dehydrogenase sensitizes cyclin E-driven ovarian cancer to CDK inhibition.
LncRNA SDHAP1 confers paclitaxel resistance of ovarian cancer by regulating EIF4G2 expression via miR-4465.
Succinate dehydrogenase subunit B inhibits the AMPK-HIF-1¿ pathway in human ovarian cancer in vitro.
oxoglutarate dehydrogenase (succinyl-transferring) deficiency
The expanding clinical spectrum of mitochondrial diseases.
Pancreatic Neoplasms
Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism.
Flow-cytometric determination of dehydrogenase activities in primary human gastrointestinal tumor cell lines.
Pancreatitis
Changes in the morphology and lability of lysosomal subpopulations in caerulein-induced acute pancreatitis.
[Effects of trental and thiotriazoline on neutrophil dehydrogenase activity in acute experimental pancreatitis]
[Protective effect of fructus gardeniae on pancreatic subcellular organs of the acute pancreatitis in rats]
Paraganglioma
18F-DOPA PET/CT in the Evaluation of Hereditary SDH-Deficiency Paraganglioma-Pheochromocytoma Syndromes.
A 40-YEAR FOLLOW-UP OF A PATIENT WITH MULTIPLE PARAGANGLIOMAS AND A SDHD MUTATION.
A bittersweet symphony.
A case of Carney triad complicated by renal cell carcinoma and a germline SDHA pathogenic variant.
A case of familial paraganglioma syndrome type 4 caused by a mutation in the SDHB gene.
A Chinese family with familial paraganglioma syndrome due to succinate dehydrogenase deficiency.
A Full Phenotype of Paraganglioma Linked to a Germline SDHB Mosaic Mutation.
A high-throughput analysis of the IDH1(R132H) protein expression in pituitary adenomas.
A Large Deletion in the Succinate Dehydrogenase B Gene (SDHB) in a Japanese Patient with Abdominal Paraganglioma and Concomitant Metastasis.
A mutation of the succinate dehydrogenase B gene in a Korean family with paraganglioma.
A novel germline SDHB mutation in a gastrointestinal stromal tumor patient without bona fide features of the Carney-Stratakis dyad.
A Novel germline SDHD mutation in a patient with recurrent familial carotid body tumor and concomitant pheochromocytoma.
A Novel Mutation (P236S) in the Succinate Dehydrogenase Subunit B Gene in a Japanese Patient with a Posterior Mediastinal Paraganglioma.
A novel mutation in the SDHD gene responsible for familial paraganglioma. Medical and psychological implications.
A novel mutation in the succinate dehydrogenase subunit D gene in siblings with the hereditary paraganglioma-pheochromocytoma syndrome.
A novel succinate dehydrogenase subunit B gene mutation, H132P, causes familial malignant sympathetic extraadrenal paragangliomas.
A novel succinate dehydrogenase subunit B germline variant associated with head and neck paraganglioma in a Dutch kindred: a family based study.
A patient with a germline SDHB mutation presenting with an isolated pituitary macroprolactinoma.
A phenotypic perspective on Mammalian oxygen sensor candidates.
A rare case of non-functioning bladder paraganglioma treated with robotic assisted partial cystectomy.
A review of the tumour spectrum of germline succinate dehydrogenase gene mutations: Beyond phaeochromocytoma and paraganglioma.
A role for succinate dehydrogenase genes in low chemoresponsiveness to hypoxia?
A SDHB malignant paraganglioma with dramatic response to temozolomide-capecitabine.
A systematic review on the genetic analysis of paragangliomas: primarily focused on head and neck paragangliomas.
A thyroid nodule revealing a paraganglioma in a patient with a new germline mutation in the succinate dehydrogenase B gene.
A Unique Case of Metastatic, Functional, Hereditary Paraganglioma Associated With an SDHC Germline Mutation.
Aberrant Splicing of SDHC in Families With Unexplained Succinate Dehydrogenase-Deficient Paragangliomas.
Active succinate dehydrogenase (SDH) and lack of SDHD mutations in sporadic paragangliomas.
Adrenocortical carcinoma and succinate dehydrogenase gene mutations.
Alterations of respiratory chain complexes in sporadic pheochromocytoma.
Altitude is a phenotypic modifier in hereditary paraganglioma type 1: evidence for an oxygen-sensing defect.
AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2? SIGNALING.
An unusual succinate dehydrogenase gene mutation C in a case of laryngeal paraganglioma.
Analysis of SDHAF3 in familial and sporadic pheochromocytoma and paraganglioma.
Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma syndrome (PGL1), in pheochromocytomas.
Assessment of MR Imaging and CT in Differentiating Hereditary and Nonhereditary Paragangliomas.
Avoiding and nonexpressing: coping styles of patients with paragangliomas.
Basic fibroblast growth factor and fibroblastic growth factor receptor-1 may contribute to head and neck paraganglioma development by an autocrine or paracrine mechanism.
Bilateral malignant paragangliomas in a patient: a rare case report.
Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene.
Cabergoline reduces 3-methoxytyramine in a SDHC patient with metastatic paraganglioma and prolactinoma.
Can subunit-specific phenotypes guide surveillance imaging decisions in asymptomatic SDH mutation carriers?
Cardiac paraganglioma with a novel germline mutation of succinate dehydrogenase gene D.
Cardiac paragangliomas: A case series with clinicopathologic features and succinate dehydrogenase B immunostaining.
Carney-Stratakis syndrome: A dyad of familial paraganglioma and gastrointestinal stromal tumor.
cDNA microarray analysis assists in diagnosis of malignant intrarenal pheochromocytoma originally masquerading as a renal cell carcinoma.
Cells silenced for SDHB expression display characteristic features of the tumor phenotype.
Cervical paragangliomas: is SDH genetic analysis systematically required?
CHARACTERISTICS AND OUTCOMES OF METASTATIC SDHB AND SPORADIC PHEOCHROMOCYTOMA/PARAGANGLIOMA: AN NATIONAL INSTITUTES OF HEALTH STUDY.
Characterization and metabolic synthetic lethal testing in a new model of SDH-loss familial pheochromocytoma and paraganglioma.
Clinical and molecular progress in hereditary paraganglioma.
Clinical aspects of SDHx-related pheochromocytoma and paraganglioma.
Clinical features of paraganglioma syndromes.
Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B (SDH-B) gene mutation carriers.
Clinical Practice Guidance: Surveillance for phaeochromocytoma and paraganglioma in paediatric succinate dehydrogenase gene mutation carriers.
Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out.
Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas.
Clinical significance and peculiarities of succinate dehydrogenase B and hypoxia inducible factor 1? expression in parasympathetic versus sympathetic paragangliomas.
Clinical utility of chromogranin A for the surveillance of succinate dehydrogenase B- and succinate dehydrogenase D-related paraganglioma.
Clinical utility of chromogranin A in SDHx-related paragangliomas.
Clinicopathologic Characteristics and Mutational Status of Succinate Dehydrogenase Genes in Paraganglioma of the Urinary Bladder: A Multi-Institutional Korean Study.
Clinicopathological, immunophenotypic and genetic studies of mediastinal paragangliomas.
Clinicoradiological manifestations of paraganglioma syndromes associated with succinyl dehydrogenase enzyme mutation.
Common genetic mutations in the start codon of the SDH subunit D gene among Chinese families with familial head and neck paragangliomas.
Comparison of 131I-MIBG, 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT Scans in a Patient With Extra Adrenal Paraganglioma Associated With SDH-B Gene Mutation.
Complete excision of large invasive retroperitoneal paraganglioma mislabelled as hypertrophic obstructive cardiomyopathy.
Composite Pheochromocytoma/Paraganglioma-Ganglioneuroma: A Clinicopathologic Study of Eight Cases with Analysis of Succinate Dehydrogenase.
Compound heterozygous mutation with a novel splice donor region DNA sequence variant in the succinate dehydrogenase subunit B gene in malignant paraganglioma.
Concurrent imaging of vascularization and metabolism in a mouse model of paraganglioma under anti-angiogenic treatment.
Continued Tumor Reduction of Metastatic Pheochromocytoma/Paraganglioma Harboring Succinate Dehydrogenase Subunit B Mutations with Cyclical Chemotherapy.
Current trends in the diagnosis and management of head and neck paragangliomas.
Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations.
DIAGNOSIS OF ENDOCRINE DISEASE: SDHx mutations: beyond pheochromocytomas and paragangliomas.
Diagnostic Role of Diffusion-Weighted and Dynamic Contrast-Enhanced Perfusion MR Imaging in Paragangliomas and Schwannomas in the Head and Neck.
Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas.
Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations.
Dopamine-Secreting Paraganglioma in the Retroperitoneum.
Early presentation of familial paraganglioma with SDHB mutation in a 13 year old child and its mother.
Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma.
Endocrine tumors associated with the vagus nerve.
Epigenetic Mutation of the Succinate Dehydrogenase C Promoter in a Patient With Two Paragangliomas.
Evaluation of Head and Neck Paragangliomas by Computed Tomography in Patients with Pheochromocytoma-Paraganglioma Syndromes.
Exploring the link between tumor metabolism and succinate dehydrogenase deficiency: a 18 F-FDOPA PET/CT study in head and neck paragangliomas.
Familial Carotid body tumors with SDHD mutations: a case series.
Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene.
Familial paraganglioma: A novel presentation of a case and response to therapy with radiolabelled MIBG.
Familial paragangliomas: case report and literature review.
Familial pheochromocytomas and paragangliomas associated with mutations of the succinate dehydrogenase genes.
Familial SDHB gene mutation in disseminated non-hypoxia-related malignant paraganglioma treated with [90Y]Y/[177Lu]Lu- DOTATATE.
FDG PET-CT imaging in head and neck paragangliomas: a center experience.
Frequent germ-line succinate dehydrogenase subunit D gene mutations in patients with apparently sporadic parasympathetic paraganglioma.
Functional consequences of a SDHB gene mutation in an apparently sporadic pheochromocytoma.
G2M arrest, blocked apoptosis, and low growth fraction may explain indolent behavior of head and neck paragangliomas.
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma.
Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibility.
Genetic and clinical characteristics of head and neck paragangliomas in a chinese population.
Genetic testing for pheochromocytoma and paraganglioma: SDHx carriers' experiences.
Genetic testing for pheochromocytoma-associated syndromes.
Genetic testing in pheochromocytoma- and paraganglioma-associated syndromes.
Genetic-clinical profile of subjects with apparently sporadic extra-adrenal paragangliomas.
GENOMIC IMPRINTING AT A BOUNDARY ELEMENT FLANKING THE SDHD LOCUS.
Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas.
Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas.
Germline SDHB mutations are common in patients with apparently sporadic sympathetic paragangliomas.
Germline SDHD mutation in familial phaeochromocytoma.
GROWTH RATE OF PARAGANGLIOMAS RELATED TO GERMLINE MUTATIONS OF THE SDHX GENES.
Head and Neck Paraganglioma Atypically Carrying a Succinate Dehydrogenase Subunit B Mutation (L157X).
Head and Neck Paragangliomas: Patterns of Otolaryngology Referrals for Genetic Testing Over 2 Decades.
Hereditary Paraganglioma in an Omani Family.
Hereditary paraganglioma targets diverse paraganglia.
Hereditary paraganglioma/pheochromocytoma and inherited succinate dehydrogenase deficiency.
Hereditary pheochromocytoma/paraganglioma syndrome with a novel mutation in the succinate dehydrogenase subunit B gene in a Japanese family: two case reports.
High frequency of germline succinate dehydrogenase mutations in sporadic cervical paragangliomas in northern Spain: mitochondrial succinate dehydrogenase structure-function relationships and clinical-pathological correlations.
High incidence of extraadrenal paraganglioma in families with SDHx syndromes detected by functional imaging with [(18)F]fluorodihydroxyphenylalanine PET.
High prevalence of founder mutations of the succinate dehydrogenase genes in the Netherlands.
High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma.
Higher risk of phaeochromocytoma/paraganglioma (Phaeo-Pgl) in SDHD than SDHB carriers: an Australian cohort study.
Identification of a 4.9-kilo base-pair Alu-mediated founder SDHD deletion in two extended paraganglioma families from Austria.
Identification of eight novel SDHB, SDHC, SDHD germline variants in Danish pheochromocytoma/paraganglioma patients.
Identification of Somatic VHL Gene Mutations in Sporadic Head and Neck Paragangliomas in Association With Activation of the HIF-1?/miR-210 Signaling Pathway.
Identification of Succinate Dehydrogenase-deficient Bladder Paragangliomas.
IDENTIFICATION OF THREE NEW VARIANTS OF SDHx GENES IN A COHORT OF PORTUGUESE PATIENTS WITH EXTRA-ADRENAL PARAGANGLIOMAS.
Illness perceptions, risk perception and worry in SDH mutation carriers.
Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes.
In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDHx Mutations in Paraganglioma.
Incomplete penetrance of a novel SDHD variation causing familial head and neck paraganglioma.
Increased Mortality in SDHB but Not in SDHD Pathogenic Variant Carriers.
Increased urinary dopamine excretion in association with bilateral carotid body tumours - clinical, biochemical and genetic findings.
Inhibition of succinate dehydrogenase dysregulates histone modifications in mammalian cells.
International consensus on initial screening and follow-up of asymptomatic SDHx mutation carriers.
Intraoperative detection of ganglioneuromas with 123I-MIBG.
Intrapericardial paraganglioma associated with succinate dehydrogenase complex subunit C mutation syndrome.
Investigation of the role of SDHB inactivation in sporadic phaeochromocytoma and neuroblastoma.
Is the c.3G>C mutation in the succinate dehydrogenase subunit D (SDHD) gene due to a founder effect in Chinese head and neck paraganglioma patients?
K40E: a novel succinate dehydrogenase (SDH)B mutation causing familial phaeochromocytoma and paraganglioma.
KIT Mutation in Gastric Gastrointestinal Stromal Tumor in a Patient With Familial Paraganglioma Syndrome Type 4.
Krebs Cycle Metabolite Profiling for Identification and Stratification of Pheochromocytomas/Paragangliomas due to Succinate Dehydrogenase Deficiency.
Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair.
L157X nonsense mutation of the succinate dehydrogenase subunit B gene in a Japanese patient with right paraaortic paraganglioma.
Lack of utility of SDHB mutation testing in adrenergic metastatic phaeochromocytoma.
Large germline deletions of mitochondrial complex II subunits SDHB and SDHD in hereditary paraganglioma.
Large Retroperitoneal Paraganglioma Associated with Germline Mutation of the Succinate Dehydrogenase Gene.
Left Atrial and Carotid Body Paraganglioma.
Li-Fraumeni Syndrome and p53 in 2015: Celebrating their Silver Anniversary.
LOH on chromosome 11q, but not SDHD and Men1 mutations was frequently detectable in Chinese patients with pheochromocytoma and paraganglioma.
Longest survive by the combination for radiation-therapy and resection in patient with metastatic spinal paragangliomas from primary-neck lesion with succinate dehydrogenase subunit B (SDHB) mutation.
Loss of heterozygosity of succinate dehydrogenase B mutation by direct sequencing in synchronous paragangliomas.
Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization.
Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics.
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.
Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism.
Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma.
Low penetrance of a SDHB mutation in a large Dutch paraganglioma family.
Malignant paraganglioma associated with succinate dehydrogenase subunit B in an 8-year-old child: the age of first screening?
Malignant paraganglioma caused by a novel germline mutation of the succinate dehydrogenase D-gene--a case report.
Malignant paragangliomas associated with mutations in the succinate dehydrogenase D gene.
Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations.
Mathematical modeling of disease dynamics in SDHB- and SDHD-related paraganglioma: Further step in understanding hereditary tumor differences and future therapeutic strategies.
Mediastinal paragangliomas related to
Mediastinal paragangliomas: association with mutations in the succinate dehydrogenase genes and aggressive behavior.
Metabolome-guided genomics to identify pathogenic variants in isocitrate dehydrogenase, fumarate hydratase, and succinate dehydrogenase genes in pheochromocytoma and paraganglioma.
Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas.
Metastatic sympathetic paraganglioma in a patient with loss of the SDHC gene.
Missense mutations in the human SDHB gene increase protein degradation without altering intrinsic enzymatic function.
MITOCHONDRIA: Succinate dehydrogenase subunit B-associated phaeochromocytoma and paraganglioma.
Mitochondrial and nuclear genes of mitochondrial components in cancer.
Mitochondrial complex II and genomic imprinting in inheritance of paraganglioma tumors.
Mitochondrial mutations in cancer.
Model animals for the study of oxidative stress from complex II.
Modeling dioxygenase enzyme kinetics in familial paraganglioma.
Molecular alterations and expression of succinate dehydrogenase complex in wild-type KIT/PDGFRA/BRAF gastrointestinal stromal tumors.
Molecular Alterations in Dog Pheochromocytomas and Paragangliomas.
Molecular characterisation of a common SDHB deletion in paraganglioma patients.
Molecular characterization of novel germline deletions affecting SDHD and SDHC in pheochromocytoma and paraganglioma patients.
Molecular genetics of paragangliomas of the skull base and head and neck region: implications for medical and surgical management.
Molecular imaging in hereditary succinate dehydrogenase mutation-related paragangliomas.
Morphologic Clues to Succinate Dehydrogenase (SDH) Deficiency in Pheochromocytomas and Paragangliomas.
Moving Beyond "Lumpology": PET/CT Imaging of Pheochromocytoma and Paraganglioma.
Multiple Paraganglioma Syndrome type 4 Secondary to Succinate Dehydrogenase B Mutation: The Diagnostic and Therapeutic Challenges of a Skull Base Paraganglioma Masquerading as Nasopharyngeal Cancer.
Multiple paragangliomas in a pregnant patient with a succinate dehydrogenase B mutation.
Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma.
Mutation analysis of the SDHD gene in four kindreds with familial paraganglioma: description of one novel germline mutation.
Mutations associated with succinate dehydrogenase D-related malignant paragangliomas.
Mutations in SDHD are the major determinants of the clinical characteristics of Dutch head and neck paraganglioma patients.
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma.
Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas.
Nationwide study of patients with head and neck paragangliomas carrying SDHB germline mutations.
Natural History and Management of Familial Paraganglioma Syndrome Type 1: Long-Term Data from a Large Family.
Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD gene.
Necessity for long-term follow-up of patients with head and neck paraganglioma (HNPGL) and mutation in the succinate dehydrogenase (SDH) gene: an index case report of "hereditary paraganglioma-phaeochromocytoma" (HPGL/PCC) like syndrome with review of pertinent literature.
Neck paraganglioma and follicular lymphoma: a case report.
New insights in the genetics of adrenocortical tumors, pheochromocytomas and paragangliomas.
New insights into the genetics of familial chromaffin cell tumors.
Newly available antibodies with practical applications in surgical pathology.
No evidence for increased mortality in SDHD variant carriers compared with the general population.
No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma.
Non-pheochromocytoma/paraganglioma tumors in patients with succinate dehydrogenase-related pheochromocytoma-paraganglioma syndromes: a clinicopathologic and molecular analysis.
Novel hereditary forms of pheochromocytomas and paragangliomas.
Novel Mutation (L157X) in the Succinate Dehydrogenase B Gene (SDHB) in a Japanese Family with Abdominal Paraganglioma Following Lung Metastasis.
Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas.
On the association of succinate dehydrogenase mutations with hereditary paraganglioma.
Orbital Paraganglioma and Succinate Dehydrogenase Staining for Genetic Testing Triage and Prognosis.
Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors.
Oxygen concentration controls epigenetic effects in models of familial paraganglioma.
p53 alterations and their relationship to SDHD mutations in parasympathetic paragangliomas.
Paraganglioma after maternal transmission of a succinate dehydrogenase gene mutation.
Paraganglioma of the Carotid Body: Treatment Strategy and SDH-gene Mutations.
Paraganglioma of the organ of Zuckerkandl associated with a somatic HIF2? mutation: A case report.
Paragangliomas Arising in the Head and Neck: A Morphologic Review and Genetic Update.
Paragangliomas in patients with mutations of the SDHD gene.
Penetrance and clinical consequences of a gross SDHB deletion in a large family.
Phaeochromocytoma: a catecholamine and oxidative stress disorder.
Phenotypic variability and risk of malignancy in SDHC-linked paragangliomas: Lessons from 3 unrelated cases with an identical germline mutation (p.Arg133*).
Pheochromocytoma and Paraganglioma in Children and Adolescents: Experience of the French Society of Pediatric Oncology (SFCE).
Pheochromocytoma: Diagnostic and Therapeutic Update.
Pheochromocytomas and Paragangliomas: An Update on Recent Molecular Genetic Advances and Criteria for Malignancy.
Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in human and mice.
Pituitary Carcinoma in a Patient with an SDHB Mutation.
Pituitary gigantism: update on molecular biology and management.
Positive Immunostaining for Succinate Dehydrogenase B (SDHB) in Paraganglioma Associated with Germline Mutation of SDHB, L157X and P236S.
Predominant Expression of Mutated Allele of the Succunate Dehydrogenase D (SDHD) Gene in the SDHD-related Paragangliomas.
Prevalence and spectrum of SDHx mutations in pheochromocytoma and paraganglioma in patients from Belgium: an update.
Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas.
Primary fibroblast co-culture stimulates growth and metabolism in Sdhb-impaired mouse pheochromocytoma MTT cells.
Primary mediastinal paraganglioma associated with a familial variant in the succinate dehydrogenase B subunit gene.
Primary Renal Paragangliomas and Renal Neoplasia Associated with Pheochromocytoma/Paraganglioma: Analysis of von Hippel-Lindau (VHL), Succinate Dehydrogenase (SDHX) and Transmembrane Protein 127 (TMEM127).
Quality of life is decreased in patients with paragangliomas.
R46Q mutation in the succinate dehydrogenase B gene (SDHB) in a Japanese family with both abdominal and thoracic paraganglioma following metastasis.
Rapid-sequence MRI for long-term surveillance for paraganglioma and phaeochromocytoma in patients with succinate dehydrogenase (SDHx) mutations.
Rare presentation of familial paraganglioma without evidence of mutation in the SDH, RET and VHL genes: towards further genetic heterogeneity.
Recent advances in the diagnosis and treatment of pheochromocytoma.
Recent advances in the genetics of SDH-related paraganglioma and pheochromocytoma.
Recent advances in the management of malignant pheochromocytoma and paraganglioma: focus on tyrosine kinase and hypoxia-inducible factor inhibitors.
Recent insights into the molecular pathogenesis of pheochromocytoma and paraganglioma.
Reduced expression and loss of heterozygosity of the SDHD gene in colorectal and gastric cancer.
Regional metastatic paraganglioma of the bladder: a rare cause of myocardial infarction, reversible cardiomyopathy and an intracardiac thrombus.
Resection of a functioning intrapericardial paraganglioma associated with succinate dehydrogenase B mutation.
Role of 68Ga-DOTATATE PET/CT in a Case of SDHB-Related Pterygopalatine Fossa Paraganglioma Successfully Controlled with Octreotide.
Role of microenvironment on neuroblastoma SK-N-AS SDHB-silenced cell metabolism and function.
Role of positron emission tomography and bone scintigraphy in the evaluation of bone involvement in metastatic pheochromocytoma and paraganglioma: specific implications for succinate dehydrogenase enzyme subunit B gene mutations.
Role of the genetic study in the management of carotid body tumor in paraganglioma syndrome.
Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate.
SDH mutations establish a hypermethylator phenotype in paraganglioma.
SDH mutations in patients affected by paraganglioma syndromes: a personal experience.
SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma-paraganglioma syndromes.
SDH5 mutations and familial paraganglioma: somewhere Warburg is smiling.
SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
SDHA is a tumor suppressor gene causing paraganglioma.
SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors.
SDHAF2 (PGL2-SDH5) and hereditary head and neck paraganglioma.
SDHB mutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma.
SDHB, SDHC, and SDHD mutation screen in sporadic and familial head and neck paragangliomas.
SDHB-Associated Paraganglioma in a Pediatric Patient and Literature Review on Hereditary Pheochromocytoma-Paraganglioma Syndromes.
SDHB-Associated Paraganglioma Syndrome in Africa-A Need for Greater Genetic Testing.
SDHB-negative jugular foramen paraganglioma manifesting malignant progression with pseudo-hypoxia related atypical uptake of [
SDHC mutations in hereditary paraganglioma/pheochromocytoma.
SDHC Promoter Methylation, a Novel Pathogenic Mechanism in Parasympathetic Paragangliomas.
SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology.
SDHx and Non-Chromaffin Tumors: A Mediastinal Germ Cell Tumor Occurring in a Young Man with Germline SDHB Mutation.
SDHx gene detection and clinical Phenotypic analysis of multiple paraganglioma in the head and neck.
SDHx-related pheochromocytoma/paraganglioma - genetic, clinical, and treatment outcomes in a series of 30 patients from a single center.
Simple and rapid characterization of novel large germline deletions in SDHB, SDHC and SDHD-related paraganglioma.
Somatic and germline mutations in the pathogenesis of pituitary adenomas.
Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma.
Somatic loss of maternal chromosome 11 causes parent-of-origin-dependent inheritance in SDHD-linked paraganglioma and phaeochromocytoma families.
SPECT and 18F-FDG PET/CT imaging of multiple paragangliomas and a growth hormone-producing pituitary adenoma as phenotypes from a novel succinate dehydrogenase subunit D mutation.
Sporadic paraganglioma caused by de novo SDHB mutations in a 6-year-old girl.
Structural and functional consequences of succinate dehydrogenase subunit B mutations.
Successful chemotherapy of hepatic metastases in a case of succinate dehydrogenase subunit B-related paraganglioma.
Successful Second-Line Metronomic Temozolomide in Metastatic Paraganglioma: Case Reports and Review of the Literature.
Succinate Dehydrogenase (SDH) D Subunit (SDHD) Inactivation in a Growth-Hormone-Producing Pituitary Tumor: A New Association for SDH?
Succinate Dehydrogenase B (SDHB)-Associated Bladder Paragangliomas.
Succinate dehydrogenase B gene mutations predict survival in patients with malignant pheochromocytomas or paragangliomas.
Succinate dehydrogenase B subunit immunohistochemical expression predicts aggressiveness in well differentiated neuroendocrine tumors of the ileum.
Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) Immunohistochemistry in Pheochromocytoma, Head and Neck Paraganglioma, Thoraco-Abdomino-Pelvic Paragangliomas: Is It a Good Idea to Use in Routine Work?
Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) - a review.
Succinate dehydrogenase gene mutation with cardiac paraganglioma: multimodality imaging and pathological correlation.
Succinate dehydrogenase gene mutations are strongly associated with paraganglioma of the organ of Zuckerkandl.
Succinate dehydrogenase gene mutations in cardiac paragangliomas.
Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics.
Succinate dehydrogenase mutation-related paragangliomas: conventional versus PET/CT diagnostic work-up.
Succinate dehydrogenase mutations: paraganglioma imaging and at-risk population screening.
Succinate dehydrogenase subunit D and succinate dehydrogenase subunit B mutation analysis in canine phaeochromocytoma and paraganglioma.
Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma.
Succinate detection using in vivo 1H-MR spectroscopy identifies germline and somatic SDHx mutations in paragangliomas.
Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas.
Succinate: a new epigenetic hacker.
Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma.
Surgical excision with left atrial reconstruction of a primary functioning retrocardiac paraganglioma.
Surgical management of the succinate dehydrogenase-associated familial paraganglioma syndromes.
Surveillance of succinate dehydrogenase gene mutation carriers: insights from a nationwide cohort.
Synchronous adrenocortical neoplasms, paragangliomas, and pheochromocytomas: syndromic considerations regarding an unusual constellation of endocrine tumors.
Synchronous carotid body and thoracic paraganglioma associated with a germline SDHC mutation.
Targeting Cyclooxygenase-2 in Pheochromocytoma and Paraganglioma: Focus on Genetic Background.
Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma.
Texture analysis of T2-weighted MRI predicts SDH mutation in paraganglioma.
The clinical phenotype of SDHC-associated hereditary paraganglioma syndrome (PGL3).
The diagnosis and management of malignant phaeochromocytoma and paraganglioma.
The genetic basis of pheochromocytoma.
The genetics of paragangliomas: a review.
The malignant potential of a succinate dehydrogenase subunit B germline mutation.
The penetrance of paraganglioma and pheochromocytoma in SDHB germline mutation carriers.
The phenotype of SDHB germline mutation carriers: a nationwide study.
The pressure rises: update on the genetics of phaeochromocytoma.
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway.
The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency.
The spectrum of SDHD mutations in Russian patients with head and neck paraganglioma.
The succinate dehydrogenase genetic testing in a large prospective series of patients with paragangliomas.
The utility of SDHB and FH immunohistochemistry in patients evaluated for hereditary paraganglioma-pheochromocytoma syndromes.
Tinnitus With Unexpected Spanish Roots: Head and Neck Paragangliomas Caused by SDHAF2 Mutation.
Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas.
Translating in vivo metabolomic analysis of succinate dehydrogenase deficient tumours into clinical utility.
Tumor-specific prognosis of mutation-positive patients with head and neck paragangliomas.
Tumour Risks and Genotype-Phenotype-Proteotype Analysis in 358 Patients with Germline Mutations in SDHB and SDHD.
UPDATE ON THE CLINICOPATHOLOGY OF PITUITARY ADENOMAS.
Urinary Bladder Paragangliomas: Analysis of Succinate Dehydrogenase and Outcome.
Utility of the succinate: Fumarate ratio for assessing SDH dysfunction in different tumor types.
Warburg Effect's Manifestation in Aggressive Pheochromocytomas and Paragangliomas: Insights from a Mouse Cell Model Applied to Human Tumor Tissue.
Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?
[Expression of SDHB, EPAS1 and MIB-1 in Zuckerkandl paragangliomas].
[Familial paraganglioma syndrome: Phenotype and relevance of a new SDHB mutation.]
[From gene to disease; from SDHD, a defect in the respiratory chain, to paragangliomas and pheochromocytomas]
[Hereditary and non-hereditary syndromic gastointestinal stromal tumours].
[Intrapericardical paraganglioma associated with mutation in succinate dehydrogenase enzyme gene.]
[Multiple and familial paragangliomas of the head and neck--review of literature and report of two cases]
[Multiple paragangliomas associated to a SDHB gene mutation: report of one case].
[Pheochromocytomas and paragangliomas: implications of new insights for diagnosis and treatment]
[The mutations of germline succinate dehydrogrnase subunit B (SDHB) in sporadic paragangliomas].
Paraganglioma, Extra-Adrenal
Higher risk of phaeochromocytoma/paraganglioma (Phaeo-Pgl) in SDHD than SDHB carriers: an Australian cohort study.
Mapping of Succinate Dehydrogenase Losses in 2258 Epithelial Neoplasms.
Methylation of the p16INK4A promoter is associated with malignant behavior in abdominal extra-adrenal paragangliomas but not pheochromocytomas.
Paralysis
Effects of altered muscle activation on oxidative enzyme activity in rat alpha-motoneurons.
Head and neck paragangliomas: A two-decade institutional experience and algorithm for management.
Paraganglioma of the recurrent laryngeal nerve.
Recurrent familial malignant carotid body tumour presenting with lymph node metastasis: case report, and review of diagnosis and management of familial carotid body tumours.
[Morphological and histochemical characteristics of the organism's reaction to administration of Cl botulinum toxin. IV. Cytochemical changes in the cells of the mesencephalic nucleus of trigeminal nerve following administration of Cl. botulinum type B toxin]
Paraparesis, Spastic
A variant of uncertain significance in SDHAF1, the succinate dehydrogenase chaperone protein, in an adult patient with spastic paraparesis and leukoencephalopathy.
Parkinson Disease
?-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.
A small molecule protects mitochondrial integrity by inhibiting mTOR activity.
Alternative mitochondrial quality control mediated by extracellular release.
Peptic Ulcer
Changes in succinic dehydrogenase of the human stomach in patients with peptic ulcer or carcinoma. A histochemical study.
Periodontitis
[The relationship of the clinical status of the periodontium and the cytochemical indices of the enzyme activity of the peripheral blood leukocytes]
Peripheral Vascular Diseases
Mitochondrial Respiration after One Session of Calf Raise Exercise in Patients with Peripheral Vascular Disease and Healthy Older Adults.
Peritonitis
Selenium-dependent metabolic reprogramming during inflammation and resolution.
Pheochromocytoma
A case of Carney triad complicated by renal cell carcinoma and a germline SDHA pathogenic variant.
A Large Deletion in the Succinate Dehydrogenase B Gene (SDHB) in a Japanese Patient with Abdominal Paraganglioma and Concomitant Metastasis.
A NOVEL DOUBLE MUTATION VAL648ILE AND VAL804LEU OF RET PROTO-ONCOGENE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2.
A Novel Mutation (P236S) in the Succinate Dehydrogenase Subunit B Gene in a Japanese Patient with a Posterior Mediastinal Paraganglioma.
A novel mutation in the succinate dehydrogenase subunit D gene in siblings with the hereditary paraganglioma-pheochromocytoma syndrome.
A novel mutation of the Succinate Dehydrogenase B Gene in a Korean Family with Pheochromocytoma.
A spontaneous paraganglioma-pheochromocytoma syndrome.
Adrenocortical carcinoma and succinate dehydrogenase gene mutations.
Aggressive Imaging Features in a Malignant Pheochromocytoma With a Novel Mutation of the SDHB Gene.
Alterations of respiratory chain complexes in sporadic pheochromocytoma.
AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2? SIGNALING.
An update on adrenal endocrinology: significant discoveries in the last 10 years and where the field is heading in the next decade.
An Update on the Histology of Pheochromocytomas: How Does it Relate to Genetics?
Analysis of SDHAF3 in familial and sporadic pheochromocytoma and paraganglioma.
Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma syndrome (PGL1), in pheochromocytomas.
Biallelic inactivation of the SDHC gene in renal carcinoma associated with paraganglioma syndrome type 3.
Calculating the optimal surveillance for head and neck paraganglioma in SDHB-mutation carriers.
Catecholamine-Induced Chest Pain Mimicking Infarction Due to an MIBG-Negative and DOPA-Positive Succinate Dehydrogenase Syndrome Subunit B-Related Pheochromocytoma.
Cells silenced for SDHB expression display characteristic features of the tumor phenotype.
CHARACTERISTICS AND OUTCOMES OF METASTATIC SDHB AND SPORADIC PHEOCHROMOCYTOMA/PARAGANGLIOMA: AN NATIONAL INSTITUTES OF HEALTH STUDY.
Characteristics of pheochromocytoma in a 4- to 20-year-old population.
Characterization and metabolic synthetic lethal testing in a new model of SDH-loss familial pheochromocytoma and paraganglioma.
Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas.
Clinical utility of chromogranin A in SDHx-related paragangliomas.
Continued Tumor Reduction of Metastatic Pheochromocytoma/Paraganglioma Harboring Succinate Dehydrogenase Subunit B Mutations with Cyclical Chemotherapy.
DIAGNOSIS OF ENDOCRINE DISEASE: SDHx mutations: beyond pheochromocytomas and paragangliomas.
Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas.
Evolving concepts in pheochromocytoma and paraganglioma.
Expression of mRNAs for succinate dehydrogenase subunits and related genes in pheochromocytoma.
Extra-adrenal and adrenal pheochromocytomas associated with a germline SDHC mutation.
Failure of MIBG scan to detect metastases in SDHB-mutated pediatric metastatic pheochromocytoma.
Familial pheochromocytomas and paragangliomas associated with mutations of the succinate dehydrogenase genes.
FDOPA Patterns in Adrenal Glands: A Pictorial Essay.
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma.
Genetic testing for pheochromocytoma and paraganglioma: SDHx carriers' experiences.
Genetic testing for pheochromocytoma-associated syndromes.
Genetic testing in pheochromocytoma- and paraganglioma-associated syndromes.
Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas.
Germ-line mutations in nonsyndromic pheochromocytoma.
Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas.
GROWTH RATE OF PARAGANGLIOMAS RELATED TO GERMLINE MUTATIONS OF THE SDHX GENES.
Hereditary paraganglioma/pheochromocytoma and inherited succinate dehydrogenase deficiency.
Hereditary pheochromocytoma/paraganglioma syndrome with a novel mutation in the succinate dehydrogenase subunit B gene in a Japanese family: two case reports.
High prevalence of founder mutations of the succinate dehydrogenase genes in the Netherlands.
Identification of eight novel SDHB, SDHC, SDHD germline variants in Danish pheochromocytoma/paraganglioma patients.
Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes.
Implications of SDHB genetic testing in patients with sporadic pheochromocytoma.
In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDHx Mutations in Paraganglioma.
Increased Mortality in SDHB but Not in SDHD Pathogenic Variant Carriers.
Inhibition of succinate dehydrogenase dysregulates histone modifications in mammalian cells.
Krebs Cycle Metabolite Profiling for Identification and Stratification of Pheochromocytomas/Paragangliomas due to Succinate Dehydrogenase Deficiency.
Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair.
LOH on chromosome 11q, but not SDHD and Men1 mutations was frequently detectable in Chinese patients with pheochromocytoma and paraganglioma.
Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization.
Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics.
Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma.
Malignant pheochromocytoma secreting vasoactive intestinal Peptide and response to sunitinib: a case report and literature review.
Mandibular Lytic Lesion in Familial Paraganglioma Syndrome Type I: A Clinical Conundrum.
Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations.
Mathematical modeling of disease dynamics in SDHB- and SDHD-related paraganglioma: Further step in understanding hereditary tumor differences and future therapeutic strategies.
Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma.
Metabolome-guided genomics to identify pathogenic variants in isocitrate dehydrogenase, fumarate hydratase, and succinate dehydrogenase genes in pheochromocytoma and paraganglioma.
Missense mutations in the human SDHB gene increase protein degradation without altering intrinsic enzymatic function.
Molecular Alterations in Dog Pheochromocytomas and Paragangliomas.
Molecular characterization of novel germline deletions affecting SDHD and SDHC in pheochromocytoma and paraganglioma patients.
Morphologic Clues to Succinate Dehydrogenase (SDH) Deficiency in Pheochromocytomas and Paragangliomas.
Moving Beyond "Lumpology": PET/CT Imaging of Pheochromocytoma and Paraganglioma.
Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma.
Neck paraganglioma and follicular lymphoma: a case report.
New insights in the genetics of adrenocortical tumors, pheochromocytomas and paragangliomas.
New insights into the genetics of familial chromaffin cell tumors.
No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma.
Novel hereditary forms of pheochromocytomas and paragangliomas.
Novel Mutation (L157X) in the Succinate Dehydrogenase B Gene (SDHB) in a Japanese Family with Abdominal Paraganglioma Following Lung Metastasis.
Novel NF1 gene mutation in a Japanese patient with neurofibromatosis type 1 and a gastrointestinal stromal tumor.
Paraganglioma after maternal transmission of a succinate dehydrogenase gene mutation.
Penetrance and clinical consequences of a gross SDHB deletion in a large family.
Phaeochromocytoma: a catecholamine and oxidative stress disorder.
Phenotypic variability and risk of malignancy in SDHC-linked paragangliomas: Lessons from 3 unrelated cases with an identical germline mutation (p.Arg133*).
Pheochromocytoma as a catecholamine producing tumor: implications for clinical practice.
Pheochromocytoma in von Hippel-Lindau disease and neurofibromatosis type 1.
Pheochromocytoma: the expanding genetic differential diagnosis.
Pheochromocytomas and Paragangliomas: An Update on Recent Molecular Genetic Advances and Criteria for Malignancy.
Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in human and mice.
Pituitary gigantism: update on molecular biology and management.
Positive Immunostaining for Succinate Dehydrogenase B (SDHB) in Paraganglioma Associated with Germline Mutation of SDHB, L157X and P236S.
Predominant Expression of Mutated Allele of the Succunate Dehydrogenase D (SDHD) Gene in the SDHD-related Paragangliomas.
Prevalence and spectrum of SDHx mutations in pheochromocytoma and paraganglioma in patients from Belgium: an update.
Primary fibroblast co-culture stimulates growth and metabolism in Sdhb-impaired mouse pheochromocytoma MTT cells.
Primary Renal Paragangliomas and Renal Neoplasia Associated with Pheochromocytoma/Paraganglioma: Analysis of von Hippel-Lindau (VHL), Succinate Dehydrogenase (SDHX) and Transmembrane Protein 127 (TMEM127).
R46Q mutation in the succinate dehydrogenase B gene (SDHB) in a Japanese family with both abdominal and thoracic paraganglioma following metastasis.
Rare presentation of familial paraganglioma without evidence of mutation in the SDH, RET and VHL genes: towards further genetic heterogeneity.
Recent advances in the diagnosis and treatment of pheochromocytoma in children.
Recent advances in the management of malignant pheochromocytoma and paraganglioma: focus on tyrosine kinase and hypoxia-inducible factor inhibitors.
Recent insights into the molecular pathogenesis of pheochromocytoma and paraganglioma.
Reduced expression and loss of heterozygosity of the SDHD gene in colorectal and gastric cancer.
Respiratory complex II in mitochondrial dysfunction-mediated cytotoxicity: Insight from cadmium.
Review: Should patients with apparently sporadic pheochromocytomas or paragangliomas be screened for hereditary syndromes?
Role of positron emission tomography and bone scintigraphy in the evaluation of bone involvement in metastatic pheochromocytoma and paraganglioma: specific implications for succinate dehydrogenase enzyme subunit B gene mutations.
Screening for genetic causes of hypertension.
SDH mutations in patients affected by paraganglioma syndromes: a personal experience.
SDHA is a tumor suppressor gene causing paraganglioma.
SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors.
SDHB mutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma.
SDHx and Non-Chromaffin Tumors: A Mediastinal Germ Cell Tumor Occurring in a Young Man with Germline SDHB Mutation.
SDHx-related pheochromocytoma/paraganglioma - genetic, clinical, and treatment outcomes in a series of 30 patients from a single center.
Significance of Alpha-inhibin Expression in Pheochromocytomas and Paragangliomas.
Simple and rapid characterization of novel large germline deletions in SDHB, SDHC and SDHD-related paraganglioma.
Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma.
Sporadic paraganglioma caused by de novo SDHB mutations in a 6-year-old girl.
Successful Second-Line Metronomic Temozolomide in Metastatic Paraganglioma: Case Reports and Review of the Literature.
Succinate Dehydrogenase (SDH)-deficient pancreatic neuroendocrine tumor expands the SDH-related tumor spectrum.
Succinate dehydrogenase B gene mutations predict survival in patients with malignant pheochromocytomas or paragangliomas.
Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) Immunohistochemistry in Pheochromocytoma, Head and Neck Paraganglioma, Thoraco-Abdomino-Pelvic Paragangliomas: Is It a Good Idea to Use in Routine Work?
Succinate detection using in vivo 1H-MR spectroscopy identifies germline and somatic SDHx mutations in paragangliomas.
Surveillance of succinate dehydrogenase gene mutation carriers: insights from a nationwide cohort.
Synchronous adrenocortical neoplasms, paragangliomas, and pheochromocytomas: syndromic considerations regarding an unusual constellation of endocrine tumors.
Targeting Cyclooxygenase-2 in Pheochromocytoma and Paraganglioma: Focus on Genetic Background.
Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma.
The genetic basis of pheochromocytoma.
The malignant potential of a succinate dehydrogenase subunit B germline mutation.
The phenotype of SDHB germline mutation carriers: a nationwide study.
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway.
The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency.
The size of the primary tumor and age at initial diagnosis are independent predictors of the metastatic behavior and survival of patients with SDHB-related pheochromocytoma and paraganglioma: a retrospective cohort study.
The utility of SDHB and FH immunohistochemistry in patients evaluated for hereditary paraganglioma-pheochromocytoma syndromes.
Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas.
Utility of the succinate: Fumarate ratio for assessing SDH dysfunction in different tumor types.
Warburg Effect's Manifestation in Aggressive Pheochromocytomas and Paragangliomas: Insights from a Mouse Cell Model Applied to Human Tumor Tissue.
Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?
[From gene to disease; from SDHD, a defect in the respiratory chain, to paragangliomas and pheochromocytomas]
[Pheochromocytomas and paragangliomas: implications of new insights for diagnosis and treatment]
Photosensitivity Disorders
The in vivo destruction of succinic dehydrogenase activity of guinea-pig skin by photosensitization with psoralen or methoxsalen.
Phyllodes Tumor
The expression of succinate dehydrogenase in breast phyllodes tumor.
Pick Disease of the Brain
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Pituitary Neoplasms
A high-throughput analysis of the IDH1(R132H) protein expression in pituitary adenomas.
A patient with a germline SDHB mutation presenting with an isolated pituitary macroprolactinoma.
Aberrant Splicing of SDHC in Families With Unexplained Succinate Dehydrogenase-Deficient Paragangliomas.
An update on the genetics of benign pituitary adenomas in children and adolescents.
Familial SDHA mutation associated with pituitary adenoma and pheochromocytoma/paraganglioma.
Genetics of gigantism and acromegaly.
Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in human and mice.
Pituitary Carcinoma in a Patient with an SDHB Mutation.
Pituitary gigantism: update on molecular biology and management.
Somatic and germline mutations in the pathogenesis of pituitary adenomas.
SPECT and 18F-FDG PET/CT imaging of multiple paragangliomas and a growth hormone-producing pituitary adenoma as phenotypes from a novel succinate dehydrogenase subunit D mutation.
Structural and functional consequences of succinate dehydrogenase subunit B mutations.
Succinate Dehydrogenase (SDH) D Subunit (SDHD) Inactivation in a Growth-Hormone-Producing Pituitary Tumor: A New Association for SDH?
Succinate dehydrogenase (SDHx) mutations in pituitary tumors: could this be a new role for mitochondrial complex II and/or Krebs cycle defects?
Succinate dehydrogenase deficiency is rare in pituitary adenomas.
Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) - a review.
Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations.
UPDATE ON THE CLINICOPATHOLOGY OF PITUITARY ADENOMAS.
Plant Diseases
Design, synthesis and antifungal/anti-oomycete activity of pyrazolyl oxime ethers as novel potential succinate dehydrogenase inhibitors.
Design, Synthesis, and Fungicidal Activities of Novel 5-Methyl-1H-1,2,3-trizole-4-carboxyl Amide Analogues.
Design, synthesis, and fungicidal evaluation of a series of novel 5-methyl-1H-1,2,3-trizole-4-carboxyl amide and ester analogues.
Molecular and Biochemical Characterization of Pydiflumetofen-Resistant Mutants of Didymella bryoniae.
Progress in understanding molecular mechanisms and evolution of resistance to succinate dehydrogenase inhibiting (SDHI) fungicides in phytopathogenic fungi
Pneumonia
Targeting alveolar-specific succinate dehydrogenase A attenuates pulmonary inflammation during acute lung injury.
[Determination of myeloperoxidase and succinate dehydrogenase in blood cells and bronchial secretion cells in acute pneumonia in children]
[Importance of the cytochemical study of blood leukocyte enzyme activity in acute pneumonias]
[Succinate dehydrogenase activity in lymphocytes of peripheral blood in the course of pneumonia and acute respiratory infections in children]
Prolactinoma
Cabergoline reduces 3-methoxytyramine in a SDHC patient with metastatic paraganglioma and prolactinoma.
Propofol Infusion Syndrome
Propofol Is Mitochondrion-Toxic and May Unmask a Mitochondrial Disorder.
Prostatic Neoplasms
Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.
Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells.
Protein Deficiency
The effect of protein deficiency on the liver of albino rats. I. The influence of different levels of dietary protein on total nitrogen, succinic dehydrogenase and xanthine oxidase in liver.
Proteinuria
[Experimental studies on the ketogenic effect of high doses of proteins in dairy cows]
protoporphyrin ferrochelatase deficiency
The mitochondrial protein frataxin is essential for heme biosynthesis in plants.
Psoriasis
Lactic dehydrogenase and succinic dehydrogenase in psoriasis.
Sustained improvement of psoriatic lesions in the course of sublingual immunotherapy for airborne allergens: clinical evidence of cross-tolerance.
[Succinic dehydrogenase activity of skin in psoriasis.]
Pulmonary Arterial Hypertension
Rats with Human Mutation of NFU1 Develop Pulmonary Hypertension.
Pulmonary Disease, Chronic Obstructive
Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor muscle.
Mitochondrial Succinate Dehydrogenase in Chronic Obstructive Pulmonary Disease: Is Complex II Too Complex?
Muscle fiber type IIX atrophy is involved in the loss of fat-free mass in chronic obstructive pulmonary disease.
Quadriceps exercise intolerance in patients with chronic obstructive pulmonary disease: the potential role of altered skeletal muscle mitochondrial respiration.
Pulmonary Edema
Experimental lung injury promotes alterations in energy metabolism and respiratory mechanics in the lungs of rats: prevention by exercise.
Pyelonephritis
[Changes in succinate dehydrogenase activity and its relationship to sodium reabsorption and potassium secretion in chronic pyelonephritis]
[Changes in succinate dehydrogenase activity in chronic pyelonephritis]
[Phosphatase and succinate dehydrogenase activity in the leukocytes in chronic pyelonephritis and chronic nephritis]
Radicular Cyst
In situ determination of different dehydrogenase activity profiles in the linings of odontogenic keratocysts and radicular cysts.
Rectal Neoplasms
Human colon cancer tissues are more sensitive than rectal cancer tissues to antitumor drugs in vitro.
Sensitivity to heat and radiation of human rectal malignant tissues in vitro.
Renal Insufficiency
Altered distribution pattern of Na+-K+-ATPase and succinate dehydrogenase activities along the nephron in human acute post-transplant renal failure.
Reperfusion Injury
Cardiac complex II activity is enhanced by fat and mediates greater mitochondrial oxygen consumption following hypoxic re-oxygenation.
Effects of electroacupuncture of different intensities on energy metabolism of mitochondria of brain cells in rats with cerebral ischemia-reperfusion injury.
Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux.
Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest.
Myocardial salvage by succinate dehydrogenase inhibition in ischemia-reperfusion injury depends on diabetes stage in rats.
Reappraisal of the e.p.r. signals in (post)-ischaemic cardiac tissue.
Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury.
The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels.
The relationship of ischemia-reperfusion injury of transplanted lung and the up-regulation of major histocompatibility complex II on host peripheral lymphocytes.
[Transmural differences between damaged cardiomyocytes due to post-ischemic reperfusion and calcium paradox]
Respiratory Insufficiency
[Effect of a mixed E. coli O-111 (RNA-azopositive and RNA-azonegative strains) and Coxsackie B3 viral infection on oxygen demand and on the succinate dehydrogenase activity of an HEp-2 cell culture according to polarographic study data]
Respiratory Tract Infections
[Succinate dehydrogenase activity in lymphocytes of peripheral blood in the course of pneumonia and acute respiratory infections in children]
Retinopathy of Prematurity
Experimental approach to the pathogenesis of retrolental fibroplasia. IX. The histochemical localization of succinic dehydrogenase in the retina of normal and oxygen-exposed animals.
Reye Syndrome
Defects of metabolism of fatty acids in the sudden infant death syndrome.
Reye's syndrome simulacra in liver of mice after treatment with chemical agents and encephalomyocarditis virus.
Rhabdomyolysis
Transient restoration of succinate dehydrogenase activity after rhabdomyolysis in iron-sulphur cluster deficiency myopathy.
Rheumatic Fever
[Cyclicity, reversibility and compensation of magnetobiological reactions in isolated cells and tissues]
Rhinitis, Allergic
Sustained improvement of psoriatic lesions in the course of sublingual immunotherapy for airborne allergens: clinical evidence of cross-tolerance.
The histological and histochemical effects of ketotifen in allergic rhinitis.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase.
Salmonella Infections
Salmonella infections in the absence of the major histocompatibility complex II.
Salpingitis
Chrono- and Immunocorrection of Inflammatory Disorders of Internal Reproductive Organs in Women of Reproductive Age.
Sarcoma
Antitumor chemosensitivity differs between clinical sarcoma and adenocarcinoma tissues.
Association of Dasatinib With Progression-Free Survival Among Patients With Advanced Gastrointestinal Stromal Tumors Resistant to Imatinib.
COMPARISON OF THE REDUCING POWER OF SOME TYPICAL TRANSPLANTABLE TUMORS AND OF TUMORS PRODUCED BY FILTERABLE VIRUSES : WITH AN APPENDIX ON THE METABOLISM OF INFECTIOUS MYXOMA OF THE RABBIT.
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
Enzyme changes induced in normal and malignant tissues with chemical agents. III. Effect of acetylpodophyllotoxin-omega-pyridinium chloride on cytochrome oxidase, cytochrome c, succinoxidase, succinic dehydrogenase, and respiration of sarcoma 37.
Establishment of Patient-derived Succinate Dehydrogenase-deficient Gastrointestinal Stromal Tumor Models For Predicting Therapeutic Response.
Metabolic Enzymes in Sarcomagenesis: Progress Toward Biology and Therapy.
The use of tetranitro-blue tetrazolium for the cytochemical localization of succinic dehydrogenase. Cytochemical and cytological studies of sarcoma 37 ascites tumor cells.
Utility of immunohistochemical investigation of SDHB and molecular genetic analysis of SDH genes in the differential diagnosis of mesenchymal tumors of GIT.
[Metabolic study of sarcoma 45 and Walker carcinosarcoma cells during the process of growth and exposure to anticoagulants (an enzyme cytochemical analysis)]
Sarcoma 180
Enzymatic responses of transplanted tumour cells towards estrogen, progesterone and testosterone.
Sarcoma 37
Enzyme changes induced in normal and malignant tissues with chemical agents. III. Effect of acetylpodophyllotoxin-omega-pyridinium chloride on cytochrome oxidase, cytochrome c, succinoxidase, succinic dehydrogenase, and respiration of sarcoma 37.
The use of tetranitro-blue tetrazolium for the cytochemical localization of succinic dehydrogenase. Cytochemical and cytological studies of sarcoma 37 ascites tumor cells.
Sarcoma, Synovial
Utility of immunohistochemical investigation of SDHB and molecular genetic analysis of SDH genes in the differential diagnosis of mesenchymal tumors of GIT.
Schistosomiasis
Histochemistry of succinic dehydrogenase in murine hepatic bilharziasis.
Seizures
Ammonia potentiates methylmalonic acid-induced convulsions and TBARS production.
Creatine protects against the convulsive behavior and lactate production elicited by the intrastriatal injection of methylmalonate.
Effects of acute hyperammonemia in vivo on oxidative metabolism in nonsynaptic rat brain mitochondria.
Heterogeneity of FHF1 related phenotype: Novel case with early onset severe attacks of apnea, partial mitochondrial respiratory chain complex II deficiency, neonatal onset seizures without neurodegeneration.
Mitochondrial toxin 3-nitropropionic acid evokes seizures in mice.
Rosmarinic acid improves oxidative stress parameters and mitochondrial respiratory chain activity following 4-aminopyridine and picrotoxin-induced seizure in mice.
Succinate accumulation contributes to oxidative stress and iron accumulation in pentylenetetrazol-induced epileptogenesis and kainic acid-induced seizure.
Succinate accumulation induces mitochondrial reactive oxygen species generation and promotes status epilepticus in the kainic acid rat model.
Ultrastructural changes in the rat cerebellar cortex during methionine sulphoximine convulsions.
Seminoma
Succinate Dehydrogenase (SDH) D Subunit (SDHD) Inactivation in a Growth-Hormone-Producing Pituitary Tumor: A New Association for SDH?
Sepsis
Heat shock pretreatment prevents cardiac mitochondrial dysfunction during sepsis.
Impact of different modalities of continuous venovenous hemofiltration on sepsis-induced alterations in experimental pancreatitis.
Impact of human sepsis on CCCTC-binding factor associated monocyte transcriptional response of Major Histocompatibility Complex II components.
Impaired energy metabolism in hearts of septic baboons: diminished activities of Complex I and Complex II of the mitochondrial respiratory chain.
Reactive oxygen species produced by liver mitochondria of rats in sepsis.
Sepsis, oxidative stress, and hypoxia: Are there clues to better treatment?
T-cell activation differentially mediates the host response to sepsis.
Shock, Septic
Impaired energy metabolism in hearts of septic baboons: diminished activities of Complex I and Complex II of the mitochondrial respiratory chain.
Silicosis
Metabolic Adaptation of Macrophages as Mechanism of Defense against Crystalline Silica.
Solitary Fibrous Tumors
Utility of immunohistochemical investigation of SDHB and molecular genetic analysis of SDH genes in the differential diagnosis of mesenchymal tumors of GIT.
Spinal Cord Injuries
Adaptations in metabolic capacity of rat soleus after paralysis.
Cycling exercise and fetal spinal cord transplantation act synergistically on atrophied muscle following chronic spinal cord injury in rats.
Rat alpha- and gamma-motoneuron soma size and succinate dehydrogenase activity are independent of neuromuscular activity level.
Sixteen weeks of testosterone with or without evoked resistance training on protein expression, fiber hypertrophy and mitochondrial health after spinal cord injury.
Spinocerebellar Ataxias
Short-term succinic acid treatment mitigates cerebellar mitochondrial OXPHOS dysfunction, neurodegeneration and ataxia in a Purkinje-specific spinocerebellar ataxia type 1 (SCA1) mouse model.
Squamous Cell Carcinoma of Head and Neck
A biochemical evaluation of oral squamous cell carcinoma growth by measurement of specific activity of succinate dehydrogenase in the subrenal capsule assay.
Chemosensitivity and DNA ploidy in head and neck squamous cell carcinomas.
Histologic differentiation and chemosensitivity of human head and neck squamous cell carcinomas.
Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status.
ST Elevation Myocardial Infarction
Citric Acid Cycle Metabolites Predict Infarct Size in Pigs Submitted to Transient Coronary Artery Occlusion and Treated with Succinate Dehydrogenase Inhibitors or Remote Ischemic Perconditioning.
Starvation
A unique COPII population in plant autophagy.
Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis.
Effect of age, starvation and circadian rhythm on the ascorbic acid content and succinic dehydrogenase activity of the kidney of male garden lizard, Calotes versicolor.
Evaluation and validation of experimental condition-specific reference genes for normalization of gene expression in Asia II-I Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae).
Liver and heart mitochondrial succinate dehydrogenase activity of newborn rats in anoxic hypoxia and starvation.
Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II.
Relationship between respiratory enzymes and survival of Escherichia coli under starvation stress in lake water.
Stability of enzymes in starving Arthrobacter crystallopoietes.
Starvation and refeeding in rats: effect on organismic respiration, cytoplasmic constituents of liver, and succinic dehydrogenase activity in liver, kidney, and heart.
Succinic dehydrogenase activity during starvation of a terrestrial pulmonate Ariophanta sp.
The AraC-type regulator RipA represses aconitase and other iron proteins from corynebacterium under iron limitation and is itself repressed by DtxR.
Status Epilepticus
Enzyme histochemistry of the rat hippocampus during experimental status epilepticus.
Stomach Neoplasms
5-Fluorouracil is converted to F-nucleotides more extensively and is more cytotoxic in poorly differentiated than in well differentiated human gastric carcinoma.
Analysis of succinate dehydrogenase subunit B gene alterations in gastric cancers.
Chemosensitivity differences between primary and metastatic lesions of clinical gastric cancer.
Clinical value of SDI test for predicting effect of postoperative chemotherapy for patients with gastric cancer.
Dipyridamole combination chemotherapy can be used safely in treating gastric cancer patients.
Expression of glutathione-S-transferases alpha and pi in gastric cancer: a correlation with cisplatin resistance.
Expression of P-glycoprotein influences resistance against anthracyclines in clinical gastric carcinomas.
Flow-cytometric determination of dehydrogenase activities in primary human gastrointestinal tumor cell lines.
Intraperitoneal cisplatin during surgery for gastric cancer and peritoneal seeding.
Poorly differentiated human gastric carcinoma is more sensitive to antitumor drugs than is well differentiated carcinoma.
Resistance to anticancer drugs of well differentiated gastric adenocarcinoma with venous invasion.
Succinate dehydrogenase inhibition test for evaluating head and neck tumors.
The succinate dehydrogenase inhibition test for evaluating biopsy specimens and resected tumors of advanced gastric cancer.
[In vitro chemosensitivity of various human tumors evaluated by the succinate dehydrogenase inhibition (SDI) test (2)]
[In vitro chemosensitivity test using collagen gel matrix for human gastric carcinomas]
[Sulfhydryl group levels and the succinate dehydrogenase activity in peripheral blood lymphocytes in patients with cancer of the stomach]
[The Efficacy of topo ?-pS10 Expression in Gastric Cancer as a Predictive Biomarker for Irinotecan Use].
[The sensitivity of 1,000 human tumors to antitumor drugs using the succinate dehydrogenase inhibition (SDI) test]
Stomach Ulcer
Protective Role of Black Tea Flavonoids Against Ethanol-Induced Gastropathy via Matrix Metalloproteinase Pathway.
REGENERATION OF PARIETAL CELLS FOLLOWING EXPERIMENTALLY PRODUCED GASTRIC ULCERS IN MICE. INTRACELLULAR SUCCINIC DEHYDROGENASE ACTIVITY AND GASTRIC PH IN UNTREATED ANIMALS.
Stroke
Exercise Training Enhances Platelet Mitochondrial Bioenergetics in Stroke Patients: A Randomized Controlled Trial.
Expression of oxidative phosphorylation genes in muscle cell cultures from patients with mitochondrial myopathies.
Predominant cerebellar volume loss as a neuroradiologic feature of pediatric respiratory chain defects.
Variables in human liver microsome preparation: impact on the kinetics of l-alpha-acetylmethadol (LAAM) n-demethylation and dextromethorphan O-demethylation.
succinate dehydrogenase deficiency
A case of Carney triad complicated by renal cell carcinoma and a germline SDHA pathogenic variant.
A Chinese family with familial paraganglioma syndrome due to succinate dehydrogenase deficiency.
A conditional mouse model of complex II deficiency manifesting as Leigh-like syndrome.
A patient with mitochondrial myopathy associated with isolated succinate dehydrogenase deficiency.
A recessive homozygous p.Asp92Gly SDHD mutation causes prenatal cardiomyopathy and a severe mitochondrial complex II deficiency.
A report of succinate dehydrogenase B deficiency associated with metastatic papillary renal cell carcinoma: successful treatment with the multi-targeted tyrosine kinase inhibitor sunitinib.
Analysis of the mitochondrial complex I-v enzyme activities of peripheral leukocytes in oxidative phosphorylation disorders.
Anesthetic management for a child with mitochondrial complex II deficiency.
Biochemical investigations and immunoblot analyses of two unrelated patients with an isolated deficiency in complex II of the mitochondrial respiratory chain.
Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency.
Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome.
Clinical and molecular genetics of patients with the Carney-Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD.
Clinical spectrum, morbidity, and mortality in 113 pediatric patients with mitochondrial disease.
Complex II deficiency--a case report and review of the literature.
Consolidating biallelic SDHD variants as a cause of mitochondrial complex II deficiency.
Deficiencies of NADH and succinate dehydrogenases in degenerative diseases and myopathies.
Deficiency of complex II of the mitochondrial respiratory chain in late-onset optic atrophy and ataxia.
Dependence of maximum performance time on work intensity in patients with a hereditary myopathy with succinate dehydrogenase deficiency.
Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate.
Effects of riboflavin in children with complex II deficiency.
Exploring the link between tumor metabolism and succinate dehydrogenase deficiency: a 18 F-FDOPA PET/CT study in head and neck paragangliomas.
Familial wild-type gastrointestinal stromal tumour in association with germline truncating variants in both SDHA and PALB2.
Good survival outcome of metastatic SDH-deficient gastrointestinal stromal tumors harboring SDHA mutations.
Hand-Assisted Laparoscopic Partial Nephrectomy for Large Renal Carcinoma with Succinate Dehydrogenase Deficiency.
Hereditary paraganglioma/pheochromocytoma and inherited succinate dehydrogenase deficiency.
Heterogeneity of FHF1 related phenotype: Novel case with early onset severe attacks of apnea, partial mitochondrial respiratory chain complex II deficiency, neonatal onset seizures without neurodegeneration.
Homozygous Gly555Glu mutation in the nuclear-encoded 70 kDa flavoprotein gene causes instability of the respiratory chain complex II.
In Vivo Multidimensional Brain Imaging in Huntington's Disease Animal Models.
Inborn errors of complex II--unusual human mitochondrial diseases.
Kearns-Sayre syndrome and complex II deficiency.
Krebs Cycle Metabolite Profiling for Identification and Stratification of Pheochromocytomas/Paragangliomas due to Succinate Dehydrogenase Deficiency.
Laparoscopic gastrectomy with lymph node dissection for the treatment of remnant stomach gastrointestinal stromal tumors in incomplete-type Carney's triad: a case report.
Late-onset optic atrophy, ataxia, and myopathy associated with a mutation of a complex II gene.
Leukoencephalopathy due to Complex II Deficiency and Bi-Allelic SDHB Mutations: Further Cases and Implications for Genetic Counselling.
Leukoencephalopathy with accumulated succinate is indicative of SDHAF1 related complex II deficiency.
Loss-of-function mutations in ISCA2 disrupt 4Fe-4S cluster machinery and cause a fatal leukodystrophy with hyperglycinemia and mtDNA depletion.
Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain.
Magnetic resonance imaging spectrum of succinate dehydrogenase-related infantile leukoencephalopathy.
Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling.
MITOCHONDRIA: Succinate dehydrogenase subunit B-associated phaeochromocytoma and paraganglioma.
Mitochondrial DNA depletion associated with partial complex II and IV deficiencies and 3-methylglutaconic aciduria.
Mitochondrial leukoencephalopathy and complex II deficiency associated with a recessive SDHB mutation with reduced penetrance.
Mitochondrial myopathy, cardiomyopathy, and pontine signal changes in an adult patient with isolated complex II deficiency.
Morphological clues to the appropriate recognition of hereditary renal neoplasms.
Multiple symmetric lipomatosis: an unusual cause of childhood obesity and mental retardation.
Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency.
Mutations in SDHD lead to autosomal recessive encephalomyopathy and isolated mitochondrial complex II deficiency.
Novel variant p.(Ala102Thr) in SDHB causes mitochondrial complex II deficiency: Case report and review of the literature.
Phenotypic variability of mitochondrial disease caused by a nuclear mutation in complex II.
Polymerase chain reaction-based diagnosis of infection with Cryptosporidium in children with primary immunodeficiencies.
Predominant cerebellar volume loss as a neuroradiologic feature of pediatric respiratory chain defects.
Propofol Is Mitochondrion-Toxic and May Unmask a Mitochondrial Disorder.
Rapamycin as a potential treatment for succinate dehydrogenase deficiency.
Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency.
Riboflavin transporter deficiency mimicking mitochondrial myopathy caused by complex II deficiency.
Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors.
Sarcoid myopathy and mitochondrial respiratory chain defects: clinicopathological, biochemical and molecular biological analyses.
SDHA mutation with dominant transmission results in complex II deficiency with ocular, cardiac, and neurologic involvement.
SDHA mutations causing a multisystem mitochondrial disease: novel mutations and genetic overlap with hereditary tumors.
Sharing the initial experience of pan-cancer panel analysis in high-risk renal cell carcinoma in the Korean population.
Single muscle fibre analyses in 2 brothers with succinate dehydrogenase deficiency.
Succinate dehydrogenase deficiency associated with dilated cardiomyopathy and ventricular noncompaction.
Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function.
Succinate dehydrogenase deficiency in a PDGFRA mutated GIST.
Succinate dehydrogenase deficiency in human.
Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors.
Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis.
Succinate dehydrogenase deficiency is rare in pituitary adenomas.
Succinate dehydrogenase deficiency.
Succinate Dehydrogenase Deficiency: A Treatable Neurometabolic Disorder.
Succinate in dystrophic white matter: a proton magnetic resonance spectroscopy finding characteristic for complex II deficiency.
SUCCINIC DEHYDROGENASE DEFICIENCY IN IDIOPATHIC CARDIOMEGALY.
SURFEIT-1 gene analysis and two-dimensional blue native gel electrophoresis in cytochrome c oxidase deficiency.
The genetic basis of isolated mitochondrial complex II deficiency.
The role of complex II in disease.
The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency.
Transient restoration of succinate dehydrogenase activity after rhabdomyolysis in iron-sulphur cluster deficiency myopathy.
Two compound frame-shift mutations in succinate dehydrogenase gene of a Chinese boy with encephalopathy.
Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency.
[Complex II deficiency due to Fp gene mutation]
[Electron transfer complex II deficiency]
[Leigh syndrome and leukodystrophy due to partial succinate dehydrogenase deficiency: regression with riboflavin]
[Leigh syndrome due to mitochondrial respiratory chain complex II deficiency].
Syringoma
Succinic dehydrogenase activity of syringomas.
Tetanus
CD4+ lymphocyte function with early human immunodeficiency virus infection.
Thiamine Deficiency
Physiological studies on the effects of nutritional imbalance on the central nervous system. II. Effects of thiamine deficiency on oxidative enzymes in the brain of chicken, Gallus domesticus.
Thymoma
Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma.
Thyroid Cancer, Papillary
Familiar Papillary Thyroid Carcinoma in a Large Brazilian Family Is Not Associated with Succinate Dehydrogenase Defects.
Thyroid Diseases
Autoantibodies to the flavoprotein subunit of succinate dehydrogenase: analysis of specificity in autoimmune thyroid disease.
Thyroid Neoplasms
A NOVEL DOUBLE MUTATION VAL648ILE AND VAL804LEU OF RET PROTO-ONCOGENE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2.
Cowden syndrome-associated germline succinate dehydrogenase complex subunit D (SDHD) variants cause PTEN-mediated down-regulation of autophagy in thyroid cancer cells.
Intragenic mutations in thyroid cancer.
Sdhd ablation promotes thyroid tumorigenesis by inducing a stem-like phenotype.
Succinate dehydrogenase D variants do not constitute a risk factor for developing C cell hyperplasia or sporadic medullary thyroid carcinoma.
Thyroid Nodule
A thyroid nodule revealing a paraganglioma in a patient with a new germline mutation in the succinate dehydrogenase B gene.
[Cyto-inactivation instantly induced by microwave ablation on thyroid nodules].
Thyrotoxicosis
[Changes in muscle fibers of the somatic type in experimental thyrotoxic myopathy]
[Histochemical characteristics of the activity of succinate dehydrogenase and cytochrome oxidase in certain tissues and organs of patients with thyrotoxicosis and animals with experimental thyroidin toxicosis]
Tics
Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans.
Tonsillitis
[Activity and distribution of succinate dehydrogenase in tonsillar tissue in patients with chronic tonsillitis]
Toxemia
[Studies of succinic dehydrogenase activity of the placenta in normal pregnancy and toxemia.]
Trichinellosis
Effect of cyclosporin A on trichinosis. A histochemical study.
Trypanosomiasis
[MALIC DEHYDROGENASE, LEUCINE AMINOPEPTIDASE AND SUCCINIC DEHYDROGENASE ACTIVITY IN THE BLOOD OF THE GUINEA PIG WITH EXPERIMENTAL TRYPANOSOMIASIS DUE TO TRYPANOSOMA CRUZI.]
Tuberculosis
3-Bromopyruvate as a potential pharmaceutical in the light of experimental data.
Effect of infection with M. tuberculosis and of tuberculin shock on the succinic dehydrogenase activity of guinea pig tissues.
Effect of infection with Mycobacterium tuberculosis and BCG on the lactic dehydrogenase and succinic dehydrogenase activity of guinea pig liver.
Electron microscopic observations on the sites of activities of succinic dehydrogenase and cytochrome oxidase in Mycobacterium tuberculosis and Bacillus megaterium.
Essentiality of succinate dehydrogenase in Mycobacterium smegmatis and its role in the generation of the membrane potential under hypoxia.
Processing of Mycobacterium tuberculosis antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by live bacilli that decrease phagosome maturation.
Succinate dehydrogenase is the regulator of respiration in Mycobacterium tuberculosis.
Succinic dehydrogenase in experimental tuberculosis: influence of isoniazid on metabolic damage.
[9th symposium on bacterial toxins. 1. On the mechanism of action of toxins. A. Enzyme level. 1. On the mechanism of interference with succinate dehydrogenase by the Mycobacterium tuberculosis cord factor.]
[HISTOCHEMICAL STUDY OF SUCCINIC DEHYDROGENASE IN TUBERCULOSIS.]
[The effect of antibacterial preparations on the activity of succinate dehydrogenase ancytochrome oxidase in the tissue of guinea pigs in experimental tuberculosis]
[Tuberculin-cytochemical test in the differential diagnosis of silicosis and silicotuberculosis with intrathoracic adenopathy]
Tuberculosis, Pulmonary
[Lymphocyte enzymes, activity of lipid peroxidation processes and the antioxidant protection of patients with tuberculosis of the lungs]
Tuberous Sclerosis
An update on the genetics of benign pituitary adenomas in children and adolescents.
Clinical and morphologic review of 60 hereditary renal tumors from 30 hereditary renal cell carcinoma syndrome patients: lessons from a contemporary single institution series.
Clinicopathological Characterization of Renal Cell Carcinoma in Young Adults: a contemporary update and review of literature.
Hereditary syndromes with associated renal neoplasia: a practical guide to histologic recognition in renal tumor resection specimens.
Morphological clues to the appropriate recognition of hereditary renal neoplasms.
Renal Cell Carcinoma with Angioleiomyoma-Like Stroma and Clear Cell Papillary Renal Cell Carcinoma: Exploring SDHB Protein Immunohistochemistry and the Relationship to Tuberous Sclerosis Complex.
The evolving classification of renal cell neoplasia.
Tularemia
Diversity of Francisella Species in Environmental Samples from Martha's Vineyard, Massachusetts.
Typhoid Fever
[Effect of ampicillin and rifampicin on biochemical and immunological processes in the organs of immunized animals]
Tyrosinemias
Acute administration of l-tyrosine alters energetic metabolism of hippocampus and striatum of infant rats.
Urinary Bladder Neoplasms
Increased expression of multidrug resistance-associated proteins in bladder cancer during clinical course and drug resistance to doxorubicin.
[Histochemical investigations on human bladder cancer (author's transl)]
[Tumorigenesis from a pathological perspective : Tumor spread and epigenetically regulated genes in bladder cancer].
Uterine Cervical Neoplasms
Histoenzymatic studies on the behavior of succinic acid dehydrogenase, NADH2 tetrazolium reductase, ATP-ase and alkaline phosphatase in cancer of the uterine cervix in women.
[Histoenzymatic studies on the behavior of succinic acid dehydrogenase, NADH-2-tetrazolium reductase, adenosine triphosphatase and alkaline phosphatase in cases of uterine cervix cancer]
Vaccinia
[Succinate dehydrogenase, NAD-H2- and NADP-H2-diaphorase activity in a culture of chick fibroblasts infected by vaccinia virus]
Vesicular Stomatitis
Inhibition of Eimeria tenella development in vitro mediated by chicken macrophages and fibroblasts treated with chicken cell supernatants with IFN-gamma activity.
Vibrio Infections
Succinate dehydrogenase mutant of Listonella anguillarum protects rainbow trout against vibriosis.
Virus Diseases
COMPARISON OF THE REDUCING POWER OF SOME TYPICAL TRANSPLANTABLE TUMORS AND OF TUMORS PRODUCED BY FILTERABLE VIRUSES : WITH AN APPENDIX ON THE METABOLISM OF INFECTIOUS MYXOMA OF THE RABBIT.
Downregulation of Light-Harvesting Complex II Induces ROS-Mediated Defense Against Turnip Mosaic Virus Infection in Nicotiana benthamiana.
Fluctuating liver functions in siblings with MPV17 mutations and possible improvement associated with dietary and pharmaceutical treatments targeting respiratory chain complex II.
[Biochemical study of experimental encephalomyocarditis virus infection; behavior of various enzyme activities in the brain; liver and myocardium (adenylpyrophosphatase, succinodehydrogenase, aspartico-ketoglutaric transaminase, rhodanese).]
[Biochemical study of experimental West Nile virus infections; behavior of succinodehydrogenase, asparticketoglutaric transaminase, adenylpyrophosphatase, rhodanese and hexokinase activity in the brain and liver.]
[Effect of a mixed E. coli O-111 (RNA-azopositive and RNA-azonegative strains) and Coxsackie B3 viral infection on oxygen demand and on the succinate dehydrogenase activity of an HEp-2 cell culture according to polarographic study data]
Vitamin A Deficiency
Effects of vitamin A deficiency on mitochondrial function in rat liver and heart.
Vocal Cord Paralysis
Recurrent familial malignant carotid body tumour presenting with lymph node metastasis: case report, and review of diagnosis and management of familial carotid body tumours.
von Hippel-Lindau Disease
Adrenal pheochromocytoma with contralateral cortisol-producing adrenal adenoma: diagnostic and therapeutic management.
Biallelic inactivation of the SDHC gene in renal carcinoma associated with paraganglioma syndrome type 3.
Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma.
Clinical and morphologic review of 60 hereditary renal tumors from 30 hereditary renal cell carcinoma syndrome patients: lessons from a contemporary single institution series.
Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas.
Evaluation of a novel germline TMEM127 mutation in an uncommon presentation.
Genetic testing for pheochromocytoma-associated syndromes.
Genetics and molecular pathogenesis of pheochromocytoma and paraganglioma.
Genetics of phaeochromocytoma.
Hereditary kidney cancer syndromes.
Hereditary syndromes with associated renal neoplasia: a practical guide to histologic recognition in renal tumor resection specimens.
Li-Fraumeni Syndrome and p53 in 2015: Celebrating their Silver Anniversary.
Morphological clues to the appropriate recognition of hereditary renal neoplasms.
Mutation analysis of HIF-prolylhydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.
Phaeochromocytoma.
Pheochromocytoma: an update on genetics and management.
Pheochromocytoma: Diagnostic and Therapeutic Update.
Recent advances in the diagnosis and treatment of pheochromocytoma.
SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma-paraganglioma syndromes.
Synchronous adrenocortical neoplasms, paragangliomas, and pheochromocytomas: syndromic considerations regarding an unusual constellation of endocrine tumors.
[Pathologist contribution in the diagnosis of hereditary predisposition to paranganglioma and pheochromocytoma].
Whooping Cough
[Study of some oxidoreductases in nerve tissue culture]
Wilms Tumor
Li-Fraumeni Syndrome and p53 in 2015: Celebrating their Silver Anniversary.
Zenker Diverticulum
Morphology of the cricopharyngeal muscle in Zenker and control specimens.