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Information on EC 1.3.5.2 - dihydroorotate dehydrogenase (quinone)

for references in articles please use BRENDA:EC1.3.5.2

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IUBMB Comments

This Class 2 dihydroorotate dehydrogenase enzyme contains FMN . The enzyme is found in eukaryotes in the mitochondrial membrane, and in some Gram negative bacteria associated with the cytoplasmic membrane [2,5]. The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides [2,4]. The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates . Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not . Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
dihydroorotate dehydrogenase, pfdhodh, hdhodh, dho-dh, hsdhodh, dihydroorotate dehydrogenase (quinone), more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-dihydroorotate + a quinone = orotate + a quinol
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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