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Information on EC 1.3.8.6 - glutaryl-CoA dehydrogenase (ETF)

for references in articles please use BRENDA:EC1.3.8.6

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IUBMB Comments

Contains FAD. The enzyme catalyses the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC 7.2.4.5, glutaconyl-CoA decarboxylase). FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyses the oxidation to glutaconyl-CoA [EC 1.3.99.32, glutaryl-CoA dehydrogenase (acceptor)].

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
glutaryl-coa dehydrogenase, glutaryl-coenzyme a dehydrogenase, gdhgeo, glutaryl coenzyme a dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(E)-glutaconyl-CoA = crotonyl-CoA + CO2
show the reaction diagram
(1b)
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glutaryl-CoA + electron-transfer flavoprotein = (E)-glutaconyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
(1a)
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glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO2 + reduced electron-transfer flavoprotein
show the reaction diagram