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Information on EC 1.4.1.12 - 2,4-diaminopentanoate dehydrogenase

for references in articles please use BRENDA:EC1.4.1.12

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IUBMB Comments

Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)].

The enzyme appears in viruses and cellular organisms

Synonyms
dapdh, 2,4-dapdh, 2,4-diaminopentanoate dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2R,4S)-2,4-diaminopentanoate + H2O + NAD(P)+ = (2R)-2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+
show the reaction diagram
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