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Information on EC 1.4.1.24 - 3-dehydroquinate synthase II

for references in articles please use BRENDA:EC1.4.1.24

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IUBMB Comments

The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization.

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
mj1249, arob', arob2, dehydroquinate synthase ii, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+ = 3-dehydroquinate + NH3 + NADH + H+
show the reaction diagram
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