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Information on EC 1.4.1.8 - valine dehydrogenase (NADP+)
for references in articles please use BRENDA:EC1.4.1.8
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EC Tree 1 Oxidoreductases
1.4 Acting on the CH-NH2 group of donors
1.4.1 With NAD+ or NADP+ as acceptor
1.4.1.8 valine dehydrogenase (NADP+)
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
showSynonyms
valdh, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
dehydrogenase, valine (nicotinamide adenine dinucleotide phosphate)
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ValDH
valine dehydrogenase (nicotinamide adenine dinucleotide phosphate)
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VDH
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ValDH
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH + H+
kinetic mechanism
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L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH + H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
amination
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Deamination
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oxidation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
L-valine:NADP+ oxidoreductase (deaminating)
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CAS REGISTRY NUMBER
COMMENTARY
37255-39-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-methionine + H2O + NAD+
4-(methylthio)-2-oxobutanoic acid + NH3 + NADH
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Substrates: VDH2: 2% of the activity with L-valine
Products: -
Products: -
r
L-valine + NAD+ + H2O
2-oxoisovalerate + NH3 + NADH
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Substrates: -
Products: -
Products: -
?
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: VDH2: 125% of the activity with L-valine
Products: VDH2: reductive amination, 116% of the activity with 2-oxoisovalerate
Products: VDH2: reductive amination, 116% of the activity with 2-oxoisovalerate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: VDH2: 125% of the activity with L-valine
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: L-2-aminobutyrate is identical with L-alpha-aminobutyrate
Products: VDH2: reductive amination, 116% of the activity with 2-oxoisovalerate
Products: VDH2: reductive amination, 116% of the activity with 2-oxoisovalerate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: L-2-aminobutyrate is identical with L-alpha-aminobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: 9% of the activity with L-leucine
Products: reductive amination: 28.1% of the activity with 2-oxoisovalerate
Products: reductive amination: 28.1% of the activity with 2-oxoisovalerate
?, r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: 9% of the activity with L-leucine
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
?, r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: L-2-aminobutyrate is identical with L-alpha-aminobutyrate
Products: reductive amination: 28.1% of the activity with 2-oxoisovalerate
Products: reductive amination: 28.1% of the activity with 2-oxoisovalerate
?, r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: L-2-aminobutyrate is identical with L-alpha-aminobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
?, r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: preferred substrate, 92.34% of the activity with L-valine
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: preferred substrate, 92.34% of the activity with L-valine
Products: reductive amination: 91.8% of the activity with 2-oxoisovalerate
Products: reductive amination: 91.8% of the activity with 2-oxoisovalerate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: L-2-aminobutyrate is identical with L-alpha-aminobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: L-2-aminobutyrate is identical with L-alpha-aminobutyrate
Products: reductive amination: 91.8% of the activity with 2-oxoisovalerate
Products: reductive amination: 91.8% of the activity with 2-oxoisovalerate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: 130% of the activity with L-valine
Products: -
Products: -
?
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: L-2-aminobutyrate is identical with L-alpha-aminobutyrate
Products: -
Products: -
?
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: VDH2: preferred substrate, 158% of the activity with L-valine
Products: VDH2: reductive amination, 100% of the activity with 2-oxoisovalerate
Products: VDH2: reductive amination, 100% of the activity with 2-oxoisovalerate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: VDH2: preferred substrate, 158% of the activity with L-valine
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: 68.9% of the activity with L-valine
Products: reductive amination: 78% of the activity with 2-oxoisovalerate
Products: reductive amination: 78% of the activity with 2-oxoisovalerate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: 68.9% of the activity with L-valine
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: L-2-aminobutyrate is identical with L-alpha-aminobutyrate
Products: reductive amination: 78% of the activity with 2-oxoisovalerate
Products: reductive amination: 78% of the activity with 2-oxoisovalerate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: L-2-aminobutyrate is identical with L-alpha-aminobutyrate
Products: VDH2: reductive amination, 100% of the activity with 2-oxoisovalerate
Products: VDH2: reductive amination, 100% of the activity with 2-oxoisovalerate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: L-2-aminobutyrate is identical with L-alpha-aminobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
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Substrates: L-2-aminobutyrate is identical with L-alpha-aminobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
Products: 2-oxobutyrate is identical with alpha-ketobutyrate
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: -
Products: -
Products: -
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: VDH2: 4.5% of the activity with L-valine
Products: pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate
Products: pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: VDH2: 4.5% of the activity with L-valine
Products: VDH2: reductive amination, 20.8% of the activity with 2-oxoisovalerate
Products: VDH2: reductive amination, 20.8% of the activity with 2-oxoisovalerate
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: 3% of the activity with L-valine
Products: reductive amination: 2% of the activity with 2-oxoisovalerate
Products: reductive amination: 2% of the activity with 2-oxoisovalerate
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: 3% of the activity with L-valine
Products: pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate
Products: pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: 13.63% of the activity with L-valine
Products: -
Products: -
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: -
Products: -
Products: -
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: 5% of the activity with L-valine
Products: -
Products: -
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: -
Products: -
Products: -
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: 14.7% of the activity with L-valine
Products: pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate
Products: pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: 14.7% of the activity with L-valine
Products: reductive amination: 31.6% of the activity with 2-oxoisovalerate
Products: reductive amination: 31.6% of the activity with 2-oxoisovalerate
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: VDH2: 8.3% of the activity with L-valine
Products: pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate
Products: pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: VDH2: 8.3% of the activity with L-valine
Products: VDH2: reductive amination, 23.3% of the activity with 2-oxoisovalerate
Products: VDH2: reductive amination, 23.3% of the activity with 2-oxoisovalerate
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: -
Products: -
Products: -
?
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
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Substrates: -
Products: pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate
Products: pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate
?
L-cysteine + H2O + NAD+
3-mercapto-2-oxopropanoate + NH3 + NADH
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Substrates: 1.87% of the activity with L-valine
Products: -
Products: -
r
L-cysteine + H2O + NAD+
3-mercapto-2-oxopropanoate + NH3 + NADH
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Substrates: 3.75% of the activity with L-valine, A124G mutant: 0.063%
Products: -
Products: -
r
L-cysteine + H2O + NAD+
3-mercapto-2-oxopropanoate + NH3 + NADH
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Substrates: -
Products: -
Products: -
?
L-cysteine + H2O + NAD+
3-mercapto-2-oxopropanoate + NH3 + NADH
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Substrates: 3% of the activity with L-valine
Products: -
Products: -
?
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: -
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: VDH2: 34% of the activity with L-valine
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: VDH2: 34% of the activity with L-valine
Products: VDH2: reductive amination, 24.5% of the activity with 2-oxoisovalerate
Products: VDH2: reductive amination, 24.5% of the activity with 2-oxoisovalerate
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: -
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
?
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: -
Products: reductive amination: 59% of the activity of 2-oxoisovalerate, but no oxidative deamination of L-isoleucine
Products: reductive amination: 59% of the activity of 2-oxoisovalerate, but no oxidative deamination of L-isoleucine
?
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: 61.3% of the activity with L-leucine
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: 61.3% of the activity with L-leucine
Products: reductive amination: 21.9% of the activity with 2-oxoisovalerate
Products: reductive amination: 21.9% of the activity with 2-oxoisovalerate
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: 27.5% of the activity with L-valine, A124G mutant: 9.98%
Products: -
Products: -
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: 12.46% of the activity with L-valine
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: 12.46% of the activity with L-valine
Products: reductive amination: 35.6% of the activity with 2-oxoisovalerate
Products: reductive amination: 35.6% of the activity with 2-oxoisovalerate
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: 27.5% of the activity with L-valine
Products: -
Products: -
?
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
-
Substrates: -
Products: -
Products: -
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: 28% of the activity with L-valine
Products: -
Products: -
?
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
-
Substrates: -
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: VDH2: 22% of the activity with L-valine
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: VDH2: 22% of the activity with L-valine
Products: VDH2: reductive amination, 16.6% of the activity with 2-oxoisovalerate
Products: VDH2: reductive amination, 16.6% of the activity with 2-oxoisovalerate
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: 29.4% of the activity with L-valine
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
Products: 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
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Substrates: 29.4% of the activity with L-valine
Products: reductive amination: 23.2% of the activity with 2-oxoisovalerate
Products: reductive amination: 23.2% of the activity with 2-oxoisovalerate
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
-
Substrates: -
Products: -
Products: -
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
-
Substrates: -
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
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Substrates: VDH2: 52.8% of the activity with L-valine
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
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Substrates: VDH2: 52.8% of the activity with L-valine
Products: VDH2: reductive amination, 26.5% of the activity with 2-oxoisovalerate
Products: VDH2: reductive amination, 26.5% of the activity with 2-oxoisovalerate
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
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Substrates: preferred substrate
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
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Substrates: preferred substrate
Products: reductive amination: 21.1% of the activity with 2-oxoisovalerate
Products: reductive amination: 21.1% of the activity with 2-oxoisovalerate
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
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Substrates: 7.46% of the activity with L-valine
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
-
Substrates: 7.46% of the activity with L-valine
Products: reductive amination: 26.85% of the activity with 2-oxoisovalerate
Products: reductive amination: 26.85% of the activity with 2-oxoisovalerate
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
-
Substrates: 15% of the activity with L-valine, A124G mutant: 5.03%
Products: -
Products: -
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
-
Substrates: 15% of the activity with L-valine
Products: -
Products: -
?
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
-
Substrates: -
Products: -
Products: -
?
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
-
Substrates: 8% of the activity with L-valine
Products: -
Products: -
?
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
-
Substrates: -
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
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Substrates: 24.5% of the activity with L-valine
Products: reductive amination: 20% of the activity with 2-oxoisovalerate
Products: reductive amination: 20% of the activity with 2-oxoisovalerate
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
-
Substrates: 24.5% of the activity with L-valine
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
-
Substrates: VDH2: 24% of the activity with L-valine
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
-
Substrates: VDH2: 24% of the activity with L-valine
Products: VDH2: reductive amination, 20% of the activity with 2-oxoisovalerate
Products: VDH2: reductive amination, 20% of the activity with 2-oxoisovalerate
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
-
Substrates: -
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
Products: 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate
r
L-norleucine + H2O + NAD+
2-oxocaproate + NADH + NH3
-
Substrates: VDH2: 18.5% of the activity with L-valine
Products: -
Products: -
r
L-norleucine + H2O + NAD+
2-oxocaproate + NADH + NH3
-
Substrates: 4.7% of the activity with L-valine
Products: reductive amination: 9.7% of the activity with 2-oxoisovalerate
Products: reductive amination: 9.7% of the activity with 2-oxoisovalerate
r
L-norleucine + H2O + NAD+
2-oxocaproate + NADH + NH3
-
Substrates: 4.7% of the activity with L-valine
Products: 2-oxocaproate is identical with 2-oxohexanoate and alpha-keto-n-hexanoate
Products: 2-oxocaproate is identical with 2-oxohexanoate and alpha-keto-n-hexanoate
r
L-norleucine + H2O + NAD+
2-oxocaproate + NADH + NH3
-
Substrates: 15% of the activity with L-valine, A124G mutant: 15%
Products: -
Products: -
r
L-norleucine + H2O + NAD+
2-oxocaproate + NADH + NH3
-
Substrates: 15% of the activity with L-valine
Products: -
Products: -
?
L-norleucine + H2O + NAD+
2-oxocaproate + NADH + NH3
-
Substrates: VDH2: 34.5% of the activity with L-valine
Products: -
Products: -
r
L-norleucine + H2O + NAD+
2-oxocaproate + NADH + NH3
-
Substrates: 51.5% of the activity with L-valine
Products: 2-oxocaproate is identical with 2-oxohexanoate and alpha-keto-n-hexanoate
Products: 2-oxocaproate is identical with 2-oxohexanoate and alpha-keto-n-hexanoate
r
L-norleucine + H2O + NAD+
2-oxocaproate + NADH + NH3
-
Substrates: 51.5% of the activity with L-valine
Products: reductive amination: 43.8% of the activity with 2-oxoisovalerate
Products: reductive amination: 43.8% of the activity with 2-oxoisovalerate
r
L-norleucine + H2O + NAD+
2-oxocaproate + NADH + NH3
-
Substrates: -
Products: 2-oxocaproate is identical with 2-oxohexanoate and alpha-keto-n-hexanoate
Products: 2-oxocaproate is identical with 2-oxohexanoate and alpha-keto-n-hexanoate
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH
-
Substrates: VDH2: 100% of the activity with L-valine
Products: -
Products: -
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH
-
Substrates: 47.2% of the activity with L-leucine
Products: reductive amination: 37% of the activity with 2-oxoisovalerate
Products: reductive amination: 37% of the activity with 2-oxoisovalerate
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH
-
Substrates: 47.2% of the activity with L-leucine
Products: 2-oxovalerate is identical with 2-oxopentanoate and alpha-ketovalerate
Products: 2-oxovalerate is identical with 2-oxopentanoate and alpha-ketovalerate
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH
-
Substrates: 100.5% of the activity of L-valine, A124G mutant: 28.77%
Products: -
Products: -
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH
-
Substrates: as active as with L-valine
Products: -
Products: -
?
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH
-
Substrates: 98% of the activity with L-valine
Products: reductive amination: 79.5% of the activity with 2-oxoisovalerate
Products: reductive amination: 79.5% of the activity with 2-oxoisovalerate
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH
-
Substrates: 98% of the activity with L-valine
Products: 2-oxovalerate is identical with 2-oxopentanoate and alpha-ketovalerate
Products: 2-oxovalerate is identical with 2-oxopentanoate and alpha-ketovalerate
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH
-
Substrates: VDH2: 96% of the activity with L-valine
Products: -
Products: -
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH
-
Substrates: -
Products: optimal chain length for reductive amination
Products: optimal chain length for reductive amination
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH
-
Substrates: -
Products: 2-oxovalerate is identical with 2-oxopentanoate and alpha-ketovalerate
Products: 2-oxovalerate is identical with 2-oxopentanoate and alpha-ketovalerate
r
L-phenylalanine + H2O + NAD+
2-oxo-3-phenylpropanoic acid + NH3 + NADH
-
Substrates: only 0.95% of the activity with L-valine
Products: -
Products: -
r
L-phenylalanine + H2O + NAD+
2-oxo-3-phenylpropanoic acid + NH3 + NADH
-
Substrates: 1.25% of the activity with L-valine, A124G mutant: 2.5%
Products: -
Products: -
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: -
Products: -
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 2.5:1
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 2.5:1
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 5:1
Products: -
Products: -
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: reductive amination: preferred substrate
Products: reductive amination: preferred substrate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: VDH is required for utilization of branched chain amino acids, the catabolism appears to be an alternative source of n-butyrate, 2-methylmalonate, and propionate needed for biosynthesis of macrolide and polyether antibiotics
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: first step in valine catabolism
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: first step in valine catabolism
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: reductive amination: preferred substrate
Products: reductive amination: preferred substrate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: VDH is required for utilization of branched chain amino acids, the catabolism appears to be an alternative source of n-butyrate, 2-methylmalonate, and propionate needed for biosynthesis of macrolide and polyether antibiotics
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: first step in valine catabolism
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: -
Products: -
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 2.5:1
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 2.5:1
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 5:1
Products: -
Products: -
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: -
Products: -
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: soluble enzyme in roots: ratio of rate of reductive amination of valine ketoanalogue to the rate of oxidative deamination of L-valine is 1:1
Products: -
Products: -
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: soluble enzyme in roots: ratio of rate of reductive amination of valine ketoanalogue to the rate of oxidative deamination of L-valine is 1:1
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: soluble enzyme in roots: ratio of rate of reductive amination of valine ketoanalogue to the rate of oxidative deamination of L-valine is 1:1
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: rate of reductive amination of ketoanalogue of valine 5 times greater than rate of oxidative deamination of L-valine
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: rate of reductive amination of ketoanalogue of valine 5 times greater than rate of oxidative deamination of L-valine
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 2.5:1
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 2.5:1
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 5:1
Products: -
Products: -
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: two forms of enzyme activity: enzyme associated with subcellular structures in shoots or leaves probably plays a biosynthetic role for valine production and the soluble enzyme in roots plays a degradative role in valine catabolism
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
Plantago sp.
-
Substrates: NADP+
Products: -
Products: -
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
Plantago sp.
-
Substrates: NADP+
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
Plantago sp.
-
Substrates: NADP+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
Plantago sp.
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 2.5:1
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
Plantago sp.
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 2.5:1
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
Plantago sp.
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 5:1
Products: -
Products: -
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: reductive amination: preferred substrate
Products: reductive amination: preferred substrate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: 88.9% of the activity with L-leucine
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: 88.9% of the activity with L-leucine
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: 88.9% of the activity with L-leucine
Products: reductive amination: preferred substrate
Products: reductive amination: preferred substrate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: preferred substrate
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: preferred substrate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: preferred substrate
Products: reductive amination: preferred substrate
Products: reductive amination: preferred substrate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: reductive amination: preferred substrate
Products: reductive amination: preferred substrate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: A124G mutant: 3.75% of the activity with L-valine in wild type
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: A124G mutant: 3.75% of the activity with L-valine in wild type
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: first catabolic step of L-valine and some other branched chain L-amino acids, important role in providing precursors for biosynthesis of polyether antibiotic, salinomycin, that is produced at a high level
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: L-valine oxidized efficiently
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: L-valine oxidized efficiently
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: first step in valine catabolism
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: L-valine oxidized efficiently
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: L-valine oxidized efficiently
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: preferred substrate
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: preferred substrate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: preferred substrate
Products: reductive amination: preferred substrate
Products: reductive amination: preferred substrate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: reductive amination: preferred substrate
Products: reductive amination: preferred substrate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: reductive amination: preferred substrate
Products: reductive amination: preferred substrate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: reductive amination rate is twice the oxidative deamination rate
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: reductive amination rate is twice the oxidative deamination rate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: reductive amination rate is twice the oxidative deamination rate
Products: reductive amination: preferred substrate
Products: reductive amination: preferred substrate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: VDH2 rather than VDH1 plays a role in metabolism of branched chain amino acids and thus in tylosin biosynthesis, expression of VDH1 is unstable
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: VDH is required for utilization of branched chain amino acids, the catabolism appears to be an alternative source of n-butyrate, 2-methylmalonate, and propionate needed for biosynthesis of macrolide and polyether antibiotics
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: regulatory enzyme involved in biosynthesis of n-butyrate, a building unit of the oligoketide antibiotic tylosin, NAD+ as natural cofactor for oxidative deamination
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: first step in valine catabolism
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: reductive amination: preferred substrate
Products: reductive amination: preferred substrate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: first step in valine catabolism
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: preferred substrate
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: preferred substrate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: preferred substrate
Products: reductive amination: preferred substrate
Products: reductive amination: preferred substrate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: NADH
Products: NADH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NAD+
Products: reductive amination: preferred substrate
Products: reductive amination: preferred substrate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: first step in valine catabolism
Products: -
Products: -
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: -
Products: -
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 2.5:1
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 2.5:1
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 5:1
Products: -
Products: -
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: -
Products: -
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: NADP+
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 2.5:1
Products: NADPH
Products: NADPH
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 2.5:1
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
Products: 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
Substrates: in the enzyme associated with subcellular structures in shoots it is 5:1
Products: -
Products: -
r
additional information
additional information
-
-
Substrates: -
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: no oxidative deamination of L-isoleucine and L-alanine
Products: no reductive amination of 2-oxobutyrate
Products: no reductive amination of 2-oxobutyrate
?
additional information
additional information
-
-
Substrates: no oxidative deamination of L-isoleucine and L-alanine
Products: no reductive amination of 2-oxobutyrate
Products: no reductive amination of 2-oxobutyrate
?
additional information
additional information
-
-
Substrates: no activity with the D-isomers of the substrates
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: Lys-79, Lys-91 are involved in substrate binding and catalysis
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: Lys-79, Lys-91 are involved in substrate binding and catalysis
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: not: D-valine
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: Ala-124 is involved in substrate binding, but less of nicotinamide coenzyme
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: not: D-valine
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: not: D-valine
Products: -
Products: -
?
additional information