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Information on EC 1.4.3.22 - diamine oxidase

for references in articles please use BRENDA:EC1.4.3.22

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IUBMB Comments

A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 (primary-amine oxidase) but unlike EC 1.4.3.4 (monoamine oxidase), they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
diamine oxidase, amine oxidase, histaminase, histamine dehydrogenase, histamine oxidase, amiloride-binding protein, dao-1, n-methylputrescine oxidase, rhdao, methylputrescine oxidase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
show the reaction diagram