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BRENDA support

Information on EC 1.5.1.1 - 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

for references in articles please use BRENDA:EC1.5.1.1

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IUBMB Comments

The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.21, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
pycr2, mu-crystallin, thyroid hormone binding protein, ketimine reductase, cytosolic thyroid hormone binding protein, pyr2c reductase, delta1-pyrroline-2-carboxylate reductase, p2c reductase, p2c/pyr2c reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-pipecolate + NAD(P)+ = 1-piperideine-2-carboxylate + NAD(P)H + H+
show the reaction diagram
L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+
show the reaction diagram