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Disease on EC 1.5.1.15 - methylenetetrahydrofolate dehydrogenase (NAD+)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
3-hydroxyacyl-coa dehydrogenase deficiency
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
5,10-methylenetetrahydrofolate reductase (fadh2) deficiency
A Novel Homozygous Non-sense Mutation in the Catalytic Domain of MTHFR Causes Severe 5,10-Methylenetetrahydrofolate Reductase Deficiency.
Severe 5,10-methylenetetrahydrofolate reductase deficiency and two MTHFR variants in an adolescent with progressive myoclonic epilepsy.
Abortion, Habitual
Analyzes of three common thrombophilic gene mutations in German women with recurrent abortions.
Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women.
Combined thrombophilic polymorphisms in women with idiopathic recurrent miscarriage.
Comparison between thrombophilic gene polymorphisms among high risk patients.
Comparison of two preventive treatments for patients with recurrent miscarriages carrying a C677T methylenetetrahydrofolate reductase mutation: 5-year experience.
Differential global and MTHFR gene specific methylation patterns in preeclampsia and recurrent miscarriages: A case-control study from North India.
Evaluation of GenoFlow Thrombophilia Array Test Kit in its detection of mutations in Factor V Leiden (G1691A), prothrombin G20210A, MTHFR C677T and A1298C in blood samples from 113 Turkish female patients.
Factor V leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriages.
Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review.
Folic acid: miscarriages, anomalies, thromboses, cancers.
Genetic thromobophilia in pregnancy: a case-control study among North Indian women.
Hereditary thrombophilia genetic variants in recurrent pregnancy loss.
Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis.
Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms in Male Partners of Recurrent Miscarriage Couples.
Methylenetetrahydrofolate Reductase Gene-specific Methylation and Recurrent Miscarriages: A Case- Control Study from North India.
Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages.
Methyltetrahydrofolate vs Folic Acid Supplementation in Idiopathic Recurrent Miscarriage with Respect to Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms: A Randomized Controlled Trial.
MTHFR C677T Polymorphism and Recurrent Early Pregnancy Loss Risk in North Indian Population.
Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain.
Plasminogen activator inhibitor-1, factor V, factor II and methylenetetrahydrofolate reductase polymorphisms in women with recurrent miscarriage.
Polymorphisms in MTHFR, MTHFD, and PAI-1 and recurrent miscarriage among North Indian women.
Pregnancy outcomes in women with epilepsy and MTHFR mutations supplemented with methylated folate and methylcobalamin (methylated B12).
Prevalent genotypes of methylenetetrahydrofolate reductase (MTHFR) in recurrent miscarriage and recurrent implantation failure.
Primary habitual abortions are associated with high frequency of factor V Leiden mutation.
Recurrent abortions in Asian Indians: no role of factor V Leiden Hong Kong/Cambridge mutation and MTHFR polymorphism.
Statistical Correlations of the Spontaneous Abortion with Trombophilia and Other Associated Pathologies.
The C677T MTHFR gene mutation is not predictive of risk for recurrent fetal loss.
The C677T polymorphism of the methylenetetrahydrofolate reductase gene and idiopathic recurrent miscarriage.
The impact of low molecular weight heparin on obstetric outcomes among unexplained recurrent miscarriages complicated with methylenetetrahydrofolate reductase gene polymorphism.
The investigation of hereditary and acquired thrombophilia risk factors in the development of complications in pregnancy in Croatian women.
The role of methylenetetrahydrofolate reductase C677T polymorphism on the peripheral blood natural killer cell proportion in women with unexplained recurrent miscarriages.
The significance of 1793G>A polymorphism in MTHFR gene in women with first trimester recurrent miscarriages.
Thrombophilias and recurrent pregnancy loss: a critical appraisal of the literature.
[Genetic conditioned changes in activity of 5,10-methylenetetrahydrofolate reductase (MTHFR) and recurrent miscarriages]
[Genetic variant C677T in the MTHFR in women with recurrent early fetal loss]
[Medical genetics in reproductive medicine]
Abortion, Missed
Maternal methyltetrahydrofolate reductase gene mutation in patients with missed abortions.
Abortion, Spontaneous
Association between gene polymorphism of folate metabolism and recurrent spontaneous abortion in Asia: A Meta-analysis.
Association Between MTHFR 1298A>C Polymorphism and Spontaneous Abortion with Fetal Chromosomal Aneuploidy.
Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?
Association of MTHFR genetic variants C677T and A1298C on predisposition to spontaneous abortion in Slavonic population.
C677T polymorphism increases the risk of early spontaneous abortion.
Combined thrombophilic mutations in women with unexplained recurrent miscarriage.
Defect of methylenetetrahydrofolate reductase in a patient with ten habitual misscarriages: a case report.
Effect of methylenetetrahydrofolate reductase and thymidylate synthase enhancer region polymorphisms on the risk of idiopathic recurrent spontaneous abortion in a Korean population.
Evidence of Paternal N5, N10 - Methylenetetrahydrofolate Reductase (MTHFR) C677T Gene Polymorphism in Couples with Recurrent Spontaneous Abortions (RSAs) in Kolar District- A South West of India.
Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review.
Gene-environment interactions: a review of effects on reproduction and development.
Gene-gene interaction between fetal MTHFR 677C>T and transcobalamin 776C>G polymorphisms in human spontaneous abortion.
Genetic thrombophilic mutations among couples with recurrent miscarriage.
Has enhanced folate status during pregnancy altered natural selection and possibly Autism prevalence? A closer look at a possible link.
Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in a patient with coronary artery disease and repetitive miscarriages.
Impaired Placentation and Early Pregnancy Loss in Patients with MTHFR Polymorphisms and Type-1 Diabetes Mellitus.
Influence of combined methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase enhancer region (TSER) polymorphisms to plasma homocysteine levels in Korean patients with recurrent spontaneous abortion.
Interaction between MTHFR 677C>T, PON1 192Q>R and PON1 55L>M polymorphisms and its effect on non-recurrent spontaneous abortion in Mexican women.
Investigation of the association between C677T polymorphism of the MTHFR gene and plasma homocysteine level in recurrent fetal miscarriage.
Management of hereditary angioedema type I and homozygous MTHFR mutation during pregnancy.
Maternal MTHFR polymorphisms and risk of spontaneous abortion.
Methylenetetrahydrofolate reductase and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implications.
Methylenetetrahydrofolate Reductase C677T and A1298C Mutations in Women with Recurrent Spontaneous Abortions in the Northwest of Iran.
Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms in Male Partners of Recurrent Miscarriage Couples.
Methylenetetrahydrofolate reductase gene promoter hypermethylation in semen samples of infertile couples correlates with recurrent spontaneous abortion.
Methylenetetrahydrofolate Reductase Polymorphisms and Pregnancy Outcome.
Methylenotetrahydrololate reductase A1298C and C677T polymorphisms and adverse pregnancy outcome in women with PCOS.
Moderately elevated first trimester fasting plasma total homocysteine is associated with increased probability of miscarriage. The Reus-Tarragona Birth Cohort Study.
MTHFR (methylenetetrahydrofolate reductase: EC 1.5.1.20) SNPs (single-nucleotide polymorphisms) and homocysteine in patients referred for investigation of fertility.
MTHFR C677T and A1298C Genotypes and Haplotypes in Slovenian Couples with Unexplained Infertility Problems and in Embryonic Tissues from Spontaneous Abortions.
MTHFR C677T and Factor V Leiden in Recurrent Pregnancy Loss: A Study Among an Endogamous Group in North India.
MTHFR C677T Polymorphism and factor V Leiden mutation are not associated with recurrent spontaneous abortion of unexplained etiology in Japanese women.
MTHFR gene polymorphism and homocysteine levels in spontaneous abortion of pregnant women.
No association of C677T methylenetetrahydrofolate reductase and an endothelial nitric oxide synthase polymorphism with recurrent pregnancy loss.
Plasminogen activator inhibitor 1 4G/5G polymorphism and coagulation factor XIII Val34Leu polymorphism: impaired fibrinolysis and early pregnancy loss.
Polymorphism for mutation of cytosine to thymine at location 677 in the methylenetetrahydrofolate reductase gene is associated with recurrent early fetal loss.
Polymorphisms in the methylene tetrahydrofolate reductase and methionine synthase reductase genes and their correlation with unexplained recurrent spontaneous abortion susceptibility.
Pregnancy outcome in patients with a history of recurrent spontaneous miscarriages and documented thrombophilias.
Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss.
Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphisms in pregnancy.
The 5, 10 methylenetetrahydrofolate reductase C677T mutation and risk of fetal loss: a case series and review of the literature.
The association of parental methylenetetrahydrofolate reductase polymorphisms (MTHFR 677C?>?T and 1298A?>?C) and fetal loss: a case-control study in South Australia.
The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations.
Thrombophilic mutations in Iranian patients with infertility and recurrent spontaneous abortion.
[C677T and A1298C mutation of the methylenetetrahydrofolate reductase gene in unexplained recurrent spontaneous abortion]
[C677T polymorphism of the methylentetrahydrofolate reductase gene as risk factor in women with recurrent abortion]
[Frequencies of C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene at the early stage of human individual development]
[Importance of the determination of MTHFR SNPs (Methylene Tetrahydrofolate Reductase Single Nucleotide Polymorphisms) in couple infertility].
[Relationship between three thrombophilic gene mutations and unexplained recurrent early spontaneous abortion]
[Study on the relationship of MTHFR polymorphisms with unexplained recurrent spontaneous abortion]
[The role of 1691G>A (Leiden) mutation in Factor V gene, 20210G>A in prothrombin gene and 677C>T in MTHFR gene in etiology of early pregnancy loss].
Abruptio Placentae
Association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with preterm delivery and placental abruption: a systematic review and meta-analysis.
Association of MTHFR 677C>T polymorphism with IUGR and placental abruption risk: A systematic review and meta-analysis.
Association of MTHFR A1298C polymorphism (but not of MTHFR C677T) with elevated homocysteine levels and placental vasculopathies.
Associations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption.
Associations between maternal methylenetetrahydrofolate reductase polymorphisms and adverse outcomes of pregnancy: the Hordaland Homocysteine Study.
Combined heterozygosity for methylenetetrahydrofolate reductase (MTHFR) mutations C677T and A1298C is associated with abruptio placentae but not with intrauterine growth restriction.
Double inherited thrombophilias and adverse pregnancy outcomes: fashion or science?
Factor V Leiden, Prothrombin and MTHFR Mutation in Patients with Preeclamsia, Intrauterine Growth Restriction and Placental Abruption.
Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review.
Frequency of selected thrombophilias in women with placental abruption.
Inheritance and perinatal consequences of inherited thrombophilia in Greece.
MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae.
MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in Finnish women.
Polymorphisms in various coagulation genes in black South African women with placental abruption.
The association between maternal methylenetetrahydrofolate reductase C677T and A1298C polymorphism and birth defects and adverse pregnancy outcomes.
[Hyperhomocysteinemia and pregnancy complications]
Acidosis
Metabolic infrastructure of pregnant women with methylenetetrahydrofolate reductase polymorphisms: A metabolomic analysis.
Acidosis, Lactic
Clinical presentation, etiology, and outcome of stroke in children: A hospital-based study.
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Acromegaly
MTHFR C677T polymorphism, folate status and colon cancer risk in acromegalic patients.
Activated Protein C Resistance
Association between in vitro fertilization outcomes and inherited thrombophilias: a meta-analysis.
Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants.
Congenital thrombophilia associated to obstetric complications.
Do placental lesions reflect thrombophilia state in women with adverse pregnancy outcome?
Double inherited thrombophilias and adverse pregnancy outcomes: fashion or science?
Factor V1691 G-A, prothrombin 20210 G-A, and methylenetetrahydrofolate reductase 677 C-T variants in Turkish children with cerebral infarct.
Hereditary Thrombophilic Factors in Glaucoma.
How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review.
Hypercoagulable states in patients with hepatocellular carcinoma.
Hyperhomocysteinemia and other thrombotic risk factors in women with placental vasculopathy.
Increased lipoprotein (a) levels as an independent risk factor for venous thromboembolism.
Lack of association between inherited thrombophilic risk factors and idiopathic sudden sensorineural hearing loss in Italian patients.
Lack of Association between Recurrent Pregnancy Loss and Inherited Thrombophilia in a Group of Colombian Patients.
Left ventricular intracardiac thrombus in a patient with Behçet disease successfully treated with immunosuppressive agents without anticoagulation: a case report and review of the literature.
Prediction of ischemic stroke in young Indians: is thrombophilia profiling a way out?
Primary thrombophilia in Mexico: a single tertiary referral hospital experience.
Profile of prothrombotic factors in Indian children with ischemic stroke.
Recurrent thrombosis in a patient with pseudohomozygous activated protein C resistance and homozygosity for MTHFR gene polymorphism C677T.
Risk factors for thrombophilia in young adults presenting with thrombosis.
Stroke in children: inherited and acquired factors and age-related variations in the presentation of 48 paediatric patients.
The frequency of factor V Leiden and concomitance of factor V Leiden with prothrombin G20210A mutation and methylene tetrahydrofolate reductase C677T gene mutation in healthy population of Denizli, Aegean region of Turkey.
The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus.
Thrombophilia and first arterial ischaemic stroke: a systematic review.
Thrombophilic risk factors in the pathogenesis of non-arteritic anterior ischemic optic neuropathy patients.
Venous thromboembolism, factor V Leiden, and methylenetetrahydrofolate reductase in a sickle cell anemia patient.
[Genetic trombophilia and markers of endotelial activation in patients with preeclampsia]
Acute Coronary Syndrome
Identification of six methylenetetrahydrofolate reductase (MTHFR) genotypes resulting from common polymorphisms: impact on plasma homocysteine levels and development of coronary artery disease.
Influence of 677 C-->T polymorphism of methylenetetrahydrofolate reductase on medium-term prognosis after acute coronary syndromes.
MTHFR C677T gene polymorphism and the severity of coronary lesions in acute coronary syndrome.
Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C).
The role of MTHFR C677T and ALDH2 Glu504Lys polymorphism in acute coronary syndrome in a Hakka population in southern China.
[Clinical course of acute coronary syndrome in dependence on containing of homozystein and ?677? methylenetetrahydrofolate reductase gene polymorphism].
acyl-coa dehydrogenase deficiency
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
Adenocarcinoma
A retrospective comparative exploratory study on two Methylentetrahydrofolate Reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patients.
Analysis of relation between C677T genotype in MTHFR gene and prostatic cancer in Iranian males.
Association of C677T and A1298C MTHFR Polymorphisms and Fluoropyrimidine-induced Toxicity in Mestizo Patients With Metastatic Colorectal Cancer.
Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.
C677T and A1298C MTHFR gene polymorphisms and response to fluoropyrimidine-based chemotherapy in Mestizo patients with metastatic colorectal cancer.
DNA Repair Gene and MTHFR Gene Polymorphisms as Prognostic Markers in Locally Advanced Adenocarcinoma of the Esophagus or Stomach Treated with Cisplatin and 5-Fluorouracil-Based Neoadjuvant Chemotherapy.
Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis.
Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma.
Genetic variations in MTHFR and gastric cardia adenocarcinoma susceptibility in the Chinese Han population.
Impact of thrombophilic gene mutations on thrombosis risk in patients with gastrointestinal carcinoma.
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population.
Methylenetetrahydrofolate reductase C677T polymorphism and risk of adenocarcinoma of the upper gastrointestinal tract.
Methylenetetrahydrofolate reductase polymorphisms/haplotypes and risk of gastric cancer: a case-control analysis in China.
Methylenetetrahydrofolate reductase tagging polymorphisms are associated with risk of esophagogastric junction adenocarcinoma: a case-control study involving 2,740 Chinese Han subjects.
MTHFR C677T polymorphism in chronic pancreatitis and pancreatic adenocarcinoma.
Polymorphisms in methylenetetrahydrofolate reductase gene (MTHFR) and the age of onset of sporadic colorectal adenocarcinoma.
Polymorphisms of MTHFR and susceptibility to oesophageal adenocarcinoma in a Caucasian United Kingdom population.
Susceptibility to gastric cardia adenocarcinoma and genetic polymorphisms in methylenetetrahydrofolate reductase in an at-risk Chinese population.
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.
[Prediction of response to neoadjuvant chemotherapy in Barrett's carcinoma by quantitative gene expression analysis]
[Single nucleotide polymorphisms in methylenetetrahydrofolate reductase gene and susceptibility to cancer of the gastric cardia in Chinese population]
Adenocarcinoma of Lung
Meta-analysis on MTHFR polymorphism and lung cancer susceptibility in East Asian populations.
MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population.
The influence of methylenetetrahydrofolate reductase and thymidylate synthetase gene polymorphisms on lung adenocarcinoma occurrence.
Adenoma
A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma.
Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction?
Dietary factors and biomarkers involved in the methylenetetrahydrofolate reductase genotype-colorectal adenoma pathway.
Dietary folate intake in combination with MTHFR C677T genotype and promoter methylation of tumor suppressor and DNA repair genes in sporadic colorectal adenomas.
Dietary intake of folate and riboflavin, MTHFR C677T genotype, and colorectal adenoma risk: a Dutch case-control study.
Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: a meta-analysis.
Folate and MTHFR: risk of adenoma recurrence in the Polyp Prevention Trial.
Folate intake, MTHFR C677T polymorphism, alcohol consumption, and risk for sporadic colorectal adenoma (United States).
Folate-genetics and colorectal neoplasia: What we know and need to know next.
Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomas.
Gene-specific DNA methylation of DNMT3B and MTHFR and colorectal adenoma risk.
Genetic and epigenetic variation in the DNMT3B and MTHFR genes and colorectal adenoma risk.
Genetic polymorphisms of methylenetetrahydrofolate reductase and aldehyde dehydrogenase 2, alcohol use and risk of colorectal adenomas: Self-Defense Forces Health Study.
Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma.
Lack of Influence of the ADH1B Arg47His Genetic Polymorphism on Risk of Colorectal Adenoma in Middle-aged Japanese Men.
Low folate status, and MTHFR 677C?>?T and MTR 2756A?>?G polymorphisms associated with colorectal cancer risk in Thais: a case-control study.
Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer.
Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice.
Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas.
Methylenetetrahydrofolate reductase, alcohol dehydrogenase, diet, and risk of colorectal adenomas.
MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom).
MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial.
MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene-environment interactions in colorectal tumorigenesis.
Quantification of gene-specific methylation of DNMT3B and MTHFR using sequenom EpiTYPER®.
Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas.
Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum.
The methylenetetrahydrofolate reductase 677C-->T polymorphism and distal colorectal adenoma risk.
Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation.
[677T mutation of the MTHFR gene in adenomas and colorectal cancer in a population sample from the Northeastern Mexico. Preliminary results]
Adenomatous Polyposis Coli
Folate status and risk of colorectal polyps in African Americans.
Polymorphisms and colorectal tumor risk.
Adenomatous Polyps
Diet and prevention of colorectal cancer.
MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom).
Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.
adenosylhomocysteinase deficiency
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Adrenal Hyperplasia, Congenital
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
Adrenoleukodystrophy
Genetic variants of methionine metabolism and X-ALD phenotype generation: results of a new study sample.
Alagille Syndrome
Agenesis of the internal carotid artery: associated malformations including a high rate of aortic and cardiac malformations.
Albuminuria
Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study.
Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya.
MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients.
Mutation C677T of methylenetetrahydrofolate reductase gene is not associated with coronary artery disease, but possibly with albuminuria, in type 2 diabetic patients.
Alcohol Withdrawal Seizures
Methylenetetrahydrofolate reductase C677T-polymorphism and its association with alcohol withdrawal seizure.
Alopecia
Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis.
MTHFR C677T Polymorphism and Serum Homocysteine Level as Risk Factors of Coronary Heart Disease in Patients with Androgenetic Alopecia: A Case Control Study.
Alopecia Areata
Methylenetetrahydrofolate reductase C677T mutation in patients with alopecia areata in Turkish population.
alpha-Thalassemia
Genetic testing costs and compliance with clinical best practices.
The clinical impact of MTHFR polymorphism on the vascular complications of sickle cell disease.
[Infratentorial ischemic stroke in children: Three case reports.]
Alzheimer Disease
A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer's disease.
Allelic Distribution of Genes for Apolipoprotein E and MTHFR in Patients with Alzheimer's Disease and Their Epistatic Interaction.
Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms.
Apolipoprotein E, methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia--an epidemiological study using the polymerase chain reaction (PCR) method.
Association Between the MTHFR Gene and Alzheimer's Disease: A Meta-Analysis.
Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease.
Association of methylenetetrahydrofolate reductase polymorphisms with susceptibility to Alzheimer's disease.
Association of MTHFR and PICALM polymorphisms with Alzheimer's disease.
Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease.
Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer's disease.
Common polymorphisms in methylenetetrahydrofolate reductase (MTHFR): relationships with plasma homocysteine concentrations and cognitive status in elderly northern italian subjects.
Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.
Epigenetic Factors in Late-Onset Alzheimer's Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B Vitamins.
Folate Pathway Gene Methylenetetrahydrofolate Reductase C677T Polymorphism and Alzheimer Disease Risk in Asian Population.
Folate, Homocysteine, Vitamin B12, and Polymorphisms of Genes Participating in One-Carbon Metabolism in Late-Onset Alzheimer's Disease Patients and Healthy Controls.
Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population.
Genetic effect of MTHFR C677T polymorphism on the structural covariance network and white-matter integrity in Alzheimer's disease.
Genetic effect of MTHFR C677T, A1298C, and A1793G polymorphisms on the age at onset, plasma homocysteine, and white matter lesions in Alzheimer's disease in the Chinese population.
Genetic polymorphisms in older subjects with vascular or Alzheimer's dementia.
Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease.
Homocysteine, apolipoproteine E and methylenetetrahydrofolate reductase in Alzheimer's disease and mild cognitive impairment.
Hyperhomocysteinemia and homozygous MTHFR 677C>T mutation finding in an Alzheimer's disease case with metabolic syndrome diagnosis.
Interaction between interleukin-8 and methylenetetrahydrofolate reductase genes modulates Alzheimer's disease risk.
Is MTHFR polymorphism a risk factor for Alzheimer's disease like APOE?
Lack of association between MTHFR A1298C variant and Alzheimer's disease: evidence from a systematic review and cumulative meta-analysis.
Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to Alzheimer's disease.
Meta-Prediction of the Effect of Methylenetetrahydrofolate Reductase Polymorphisms and Air Pollution on Alzheimer's Disease Risk.
Methylenetetrahydrofolate reductase (MTHFR) C667T polymorphism and susceptibility to late-onset Alzheimer's disease in the Italian population. A systematic review and meta-analysis.
Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Alzheimer Disease Risk: a Meta-Analysis.
Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients.
Methylenetetrahydrofolate reductase gene and risk of Alzheimer's disease in Koreans.
Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland.
MTHFR Gene Mutations: A Potential Marker of Late-Onset Alzheimer's Disease?
Relationship between genetic polymorphism, serum folate and homocysteine in Alzheimer's disease.
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
The C677T methylenetetrahydrofolate reductase mutation is not associated with Alzheimer's disease.
The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene and vascular dementia.
The C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene and Susceptibility to Late-onset Alzheimer's Disease.
The Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk for Late-Onset Alzheimer's disease: Further Evidence in an Italian Multicenter Study.
The MTHFR 677T allele may influence the severity and biochemical risk factors of Alzheimer's disease in an Egyptian population.
The MTHFR C677T polymorphism contributes to increased risk of Alzheimer's disease: evidence based on 40 case-control studies.
The regulatory region polymorphisms of the MTHFR gene are not associated with Alzheimer's disease.
The sex-specific effect of the apolipoprotein E allele and methylenetetrahydrofolate reductase gene polymorphism on the biochemical, anatomical, and cognitive profiles of patients clinically diagnosed with probable Alzheimer's disease.
[Alzheimer's disease and methylenetetrahydrofolate reductase gene polymorphisms: a potential nutrigenomic approach for Mexico]
[Stroke and the genetics of hyperhomocysteinemia]
Amyotrophic Lateral Sclerosis
Association between C677T polymorphism of MTHFR gene and risk of amyotrophic lateral sclerosis: Polish population study and a meta-analysis.
Gender-Specific Association of Methylenetetrahydrofolate Reductase Gene Polymorphisms with Sporadic Amyotrophic Lateral Sclerosis.
MTHFR C677T allelic variant is not associated with plasma and cerebrospinal fluid homocysteine in amyotrophic lateral sclerosis.
Anemia
A C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism and G20210A mutation in the prothrombin gene of sickle cell anemia patients from Northeast Brazil.
Association of C677T and A1298C MTHFR Polymorphisms and Fluoropyrimidine-induced Toxicity in Mestizo Patients With Metastatic Colorectal Cancer.
Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival.
Gene-Gene Interactions of Gemcitabine Metabolizing-Enzyme Genes hCNT3 and WEE1 for Preventing Severe Gemcitabine-Induced Hematological Toxicity.
High dose methotrexate treatment in childhood ALL: pilot study on the impact of the MTHFR 677C>T and 1298A>C polymorphisms on MTX-related toxicity.
Homozygous MTHFR C677T gene mutation and recurrent stroke in an infant.
Methionine synthase deficiency without megaloblastic anaemia.
Methylene tetrahydrofolate reductase gene mutation in sickle cell anaemia patients in Lagos, Nigeria.
Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma.
MTHFR polymorphisms involved in vitamin B12 deficiency associated with atrophic gastritis.
Study of specific genetic and epigenetic variables in multiple myeloma.
The Methylenetetrahydrofolate Reductase C677T (rs1801133) and Apolipoprotein A5-1131T>C (rs662799) Polymorphisms, and Anemia Are Independent Risk Factors for Ischemic Stroke.
Venous thromboembolism, factor V Leiden, and methylenetetrahydrofolate reductase in a sickle cell anemia patient.
Anemia, Diamond-Blackfan
A child with Diamond-Blackfan anemia, methylenetetrahydrofolate reductase mutation, and perinatal stroke.
Anemia, Hemolytic
Hemolysis and hyperhomocysteinemia caused by cobalamin deficiency: three case reports and review of the literature.
Anemia, Iron-Deficiency
Homozygous MTHFR C677T gene mutation and recurrent stroke in an infant.
Anemia, Megaloblastic
Acute leukoencephalopathy possibly induced by phenytoin intoxication in an adult patient with methylenetetrahydrofolate reductase deficiency.
Hyperhomocysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient.
Methionine synthase deficiency without megaloblastic anaemia.
Update on cobalamin, folate, and homocysteine.
Anemia, Pernicious
[Portal and mesenteric vein thrombosis associated with hyperhomocysteinemia and pernicious anemia in a patient heterozygous for the MTHFR C677T mutation.]
Anemia, Sickle Cell
A C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism and G20210A mutation in the prothrombin gene of sickle cell anemia patients from Northeast Brazil.
Association between MTHFR 677C>T polymorphism and vascular complications in sickle cell disease: A meta-analysis.
Association of the Methylenetetrahydrofolate Reductase A1298C but not the C677T Single Nucleotide Polymorphism with Sickle Cell Disease in Bahrain.
Clinical impact of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations among sickle cell disease patients of Central India.
Correlation of the C677T MTHFR genotype with homocysteine levels in children with sickle cell disease.
Factor V Leiden G1691A, Prothrombin G20210A, and MTHFR C677T and A1298C Mutations in Patients With Sickle Cell Disease in Tunisia.
Factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations among patients with sickle cell disease in Eastern Saudi Arabia.
Frequency of the 677 C-->T mutation of the methylenetetrahydrofolate reductase gene among Kuwaiti sickle cell disease patients.
Frequency of the MTHFR C677T polymorphism in Yemeni children with sickle cell disease.
Incidence of thrombophilia in patients with Gaucher disease.
Methylene tetrahydrofolate reductase gene mutation in sickle cell anaemia patients in Lagos, Nigeria.
Methylenetetrahydrofolate reductase polymorphisms as genetic markers to predict homocysteinemia and clinical severity in sickle cell disease.
Prothrombin mutant, factor V Leiden, and thermolabile variant of methylenetetrahydrofolate reductase among patients with sickle cell disease in Brazil.
The 844ins68 cystathionine beta-synthase and C677T MTHFR gene polymorphism and the vaso-occlusive event risk in sickle cell disease.
The clinical impact of MTHFR polymorphism on the vascular complications of sickle cell disease.
The methylene tetrahydrofolate reductase (C677T) mutation as a potential risk factor for avascular necrosis in sickle cell disease.
The methylenetetrahydrofolate reductase gene C677T mutant and ischemic stroke in sickle cell disease.
The methylenetetrahydrofolate reductase gene C677T polymorphism in patients with homozygous sickle cell disease and stroke.
The Prevalence of Factor V Leiden (G1691A) and Methylenetetrahydrofolate Reductase C677T Mutations in Sickle Cell Disease in Western India.
Thrombophilic Mutations Among Patients with Sickle Cell Disease.
Venous thromboembolism, factor V Leiden, and methylenetetrahydrofolate reductase in a sickle cell anemia patient.
Anencephaly
5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects.
Amniotic fluid homocysteine levels, 5,10-methylenetetrahydrafolate reductase genotypes, and neural tube closure sites.
Effect on risk of anencephaly of gene-nutrient interactions between methylenetetrahydrofolate reductase C677T polymorphism and maternal folate, vitamin B12 and homocysteine profile.
Methylenetetrahydrofolate reductase gene polymorphisms and the risk of anencephaly in Mexico.
Variants in maternal COMT and MTHFR genes and risk of neural tube defects in offspring.
Aneurysm
Brachial artery aneurysm accompanying a homozygous methylenetetrahydrofolate reductase mutation.
How to Understand Patent Foramen Ovale Clinical Significance: Part I.
Hyperhomocysteinemia during aortic aneurysm, a plausible role of epigenetics.
Methylation map genes can be critical in determining the methylome of intracranial aneurysm patients.
Relationship of genetic factors with development of aortic dissection and aneurysm.
Aneurysm, Dissecting
Relationship of genetic factors with development of aortic dissection and aneurysm.
Angelman Syndrome
Methylenetetrahydrofolate reductase deficiency in a patient with phenotypic findings of Angelman syndrome.
Angina, Unstable
Genetic risk factors in acute coronary disease.
Angioedemas, Hereditary
Hereditary angioedema type III, recurrent pregnancy loss and heterozygous MTHFR mutation.
Management of hereditary angioedema type I and homozygous MTHFR mutation during pregnancy.
Successful management of hereditary angioedema during pregnancy in a patient with heterozygous MTHFR mutation.
Anorectal Malformations
No major role for periconceptional folic acid use and its interaction with the MTHFR C677T polymorphism in the etiology of congenital anorectal malformations.
Antiphospholipid Syndrome
Acute adrenal failure associated with primary antiphospholipid syndrome and homozygosity for MTHFR C677T.
Case report: Acute myocardial infarction in a 32-year-old white male found to have antiphospholipid antibody syndrome and MTHFR mutation homozygosity.
Co-existence of renovascular hypertension, polyarteritis nodosa, antiphospholipid syndrome and methylenetetrahydrofolate reductase mutation.
Evaluation of cerebral venous thrombosis secondary to oral contraceptive use in adolescents.
Impact of plasma homocysteine and prothrombin G20210 A on primary antiphospholipid syndrome.
Recurrent miscarriage syndrome and infertility due to blood coagulation protein/platelet defects: a review and update.
Review article: the aetiology of primary Budd-Chiari syndrome - differences between the West and China.
Statistical Correlations of the Spontaneous Abortion with Trombophilia and Other Associated Pathologies.
The impact of the search for thrombophilia risk factors among antiphospholipid syndrome patients with thrombosis.
[Cerebral venous thrombosis: when etiology makes the difference.]
[FETAL LOSSES DURING THE MATURATION OF THE PLACENTA AND THE RELATIONSHIP WITH SOME PROCOAGULANT CONDITIONS.]
[Prevalence of thrombophilic conditions and genetic carrier status in neuroischaemic form of diabetic foot].
[Prognostic value of allelic variants affecting the hemostatic system in the development of antiphospholipid syndrome and kidney lesion in patients with systemic lupus erythematosus].
Antithrombin III Deficiency
Adverse pregnancy outcomes are associated with multiple maternal thrombophilic factors.
Etiology of hypercoagulable state in women with recurrent fetal loss without other causes of miscarriage from Southern Italy: new clinical target for antithrombotic therapy.
Evaluation of cerebral venous thrombosis secondary to oral contraceptive use in adolescents.
Inherited and acquired thrombophilias and poor pregnancy outcome: should we be treating with heparin?
Inherited prothrombotic defects in Budd-Chiari syndrome and portal vein thrombosis: a study from North India.
Ischemic stroke subtypes and thrombophilia in young and elderly Brazilian stroke patients admitted to a rehabilitation hospital.
Outcome after kidney transplantation in children with thrombotic risk factors.
Review of Management and Outcomes in Women with Thrombophilia Risk during Pregnancy at a Single Institution.
Risk factors for thrombophilia in young adults presenting with thrombosis.
The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus.
Thrombophilia in young patients with acute myocardial infarction.
Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage.
Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study.
[Acquired and inherited hypercoagulability among patients with cerebral venous thrombosis]
Aortic Aneurysm
Hyperhomocysteinemia during aortic aneurysm, a plausible role of epigenetics.
Aortic Aneurysm, Abdominal
Association between MTHFR C677T polymorphism and abdominal aortic aneurysm risk: A comprehensive meta-analysis with 10,123 participants involved.
Hyperhomocysteinaemia is an independent risk factor of abdominal aortic aneurysm in a Chinese Han population.
Hyperhomocysteinaemia, low folate concentrations and MTHFR C677T mutation in abdominal aortic aneurysm.
Increased risk of the abdominal aortic aneurysm in carriers of the MTHFR 677T allele.
Methylenetetrahydrofolate reductase mutation in subjects with abdominal aortic aneurysm subdivided for age.
Plasma total homocysteine is associated with abdominal aortic aneurysm and aortic diameter in older men.
The methylenetetrahydrofolate reductase C677T polymorphism does not associate with susceptibility to abdominal aortic aneurysm.
[The different genotypes of MTHFR 1298A>C and PON1 -108C>T polymorphisms confer the increased risk of the abdominal aortic aneurysm in the smoking and nonsmoking persons]
[The normotensive carriers of the MTHFR 677T allele, displaying the increased risk of development of the abdominal aortic aneurysm (AAA), occur at the highest frequency among the smoking patients]
Aortic Aneurysm, Thoracic
First genetic analysis of aneurysm genes in familial and sporadic abdominal aortic aneurysm.
Aortic Valve Stenosis
Risk of congenital heart defects is influenced by genetic variation in folate metabolism.
Aphasia
Ischemic Stroke in a Patient With Atrial Tachycardia, Methylenetetrahydrofolate Reductase Mutation and New-Onset Atrial Fibrillation: Is Early Initiation of Anticoagulation Therapy Indicated?
Apnea
Methylenetetrahydrofolate reductase deficiency: importance of early diagnosis.
aromatic-l-amino-acid decarboxylase deficiency
Targeted cerebrospinal fluid analysis for inborn errors of metabolism on an LC-MS/MS analysis platform.
Arsenic Poisoning
Increased neurotoxicity of arsenic in methylenetetrahydrofolate reductase deficiency.
[Study on the relationship between methylenetetra-hydrofolatereductase gene (677C-->T) mutation and skin lesions in endemic arsenic poisoning]
Arterial Occlusive Diseases
C677T substitution in the methylenetetrahydrofolate reductase gene as a risk factor for venous thrombosis and arterial disease in selected patients.
Contribution of the cystathionine beta-synthase gene (844ins68) polymorphism to the risk of early-onset venous and arterial occlusive disease and of fasting hyperhomocysteinemia.
Polymorphism in the methylenetetrahydrofolate reductase (C677T) gene and homocysteine levels: a comparison in Brazilian patients with coronary arterial disease, ischemic stroke and peripheral arterial obstructive disease.
Arteriosclerosis
Association of plasma homocysteine with serum interleukin-6 and C-peptide levels in patients with type 2 diabetes.
General anesthesia and methylenetetrahydrofolate reductase deficiency.
Homocysteine and the pathogenesis of atherosclerosis.
The model homologue of the partially defective human 5,10-methylenetetrahydrofolate reductase, considered as a risk factor for stroke due to increased homocysteine level, can be protected and reactivated by heat shock proteins.
Arteriovenous Fistula
Are homocysteine and MTHFR genotype polymorphism associated with arteriovenous fistula patency?
The methylentetrahydrofolate reductase C677T point mutation is a risk factor for vascular access thrombosis in hemodialysis patients.
Arteriovenous Malformations
The incidence of severe intraventricular hemorrhage based on retrospective analysis of 35939 full-term newborns-report of two cases and review of literature.
Arthritis
677TT genotype is associated with elevated risk of methotrexate (MTX) toxicity in juvenile idiopathic arthritis: treatment outcome, erythrocyte concentrations of MTX and folates, and MTHFR polymorphisms.
Cardiovascular events are not associated with MTHFR polymorphisms, but are associated with methotrexate use and traditional risk factors in US veterans with rheumatoid arthritis.
Complete clinical and functional recovery following low-dose methotrexate related paraparesis in a patient with compound c.1298A>C AND c.677C>T MTHFR polymorphism: A case report.
Influence of methylenetetrahydrofolate reductase polymorphisms on efficacy and toxicity of methotrexate in patients with juvenile idiopathic arthritis.
Mutations in the MTHFR gene are not associated with Methotrexate intolerance in patients with juvenile idiopathic arthritis.
Arthritis, Juvenile
677TT genotype is associated with elevated risk of methotrexate (MTX) toxicity in juvenile idiopathic arthritis: treatment outcome, erythrocyte concentrations of MTX and folates, and MTHFR polymorphisms.
Influence of methylenetetrahydrofolate reductase polymorphisms on efficacy and toxicity of methotrexate in patients with juvenile idiopathic arthritis.
Mutations in the MTHFR gene are not associated with Methotrexate intolerance in patients with juvenile idiopathic arthritis.
Arthritis, Rheumatoid
677C > T and 1298A > C MTHFR polymorphisms affect arechin treatment outcome in rheumatoid arthritis.
677C>T and 1298A>C MTHFR polymorphisms affect methotrexate treatment outcome in rheumatoid arthritis.
A novel single nucleotide polymorphism of the human methylenetetrahydrofolate reductase gene in Japanese individuals.
A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis.
Anti-tumour necrosis factor-alpha response associated with combined CD226 and HLA-DRB1[*]0404 haplotype in rheumatoid arthritis.
Association Between MTHFR C677T Polymorphism and Methotrexate Treatment Outcome in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis.
Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients.
Association of MTHFR and RFC1 gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis.
Association of MTHFR C677T and A1298C gene polymorphisms with methotrexate efficiency and toxicity in Algerian rheumatoid arthritis patients.
Association of the MTHFR C677T and A1298C polymorphisms with methotrexate toxicity in rheumatoid arthritis: a meta-analysis.
Associations between asymmetric dimethylarginine, homocysteine, and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) in rheumatoid arthritis.
Associations between C677T and A1298C polymorphisms of MTHFR and susceptibility to rheumatoid arthritis: a systematic review and meta-analysis.
Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients.
Associations between single-nucleotide polymorphisms of RFC-1, GGH, MTHFR, TYMS and TCII and the efficacy and toxicity of methotrexate treatment in patients with rheumatoid arthritis.
Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis.
Associations between the genetic polymorphisms of MTHFR and outcomes of methotrexate treatment in rheumatoid arthritis.
Associations of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms with genetic susceptibility to rheumatoid arthritis: a meta-analysis.
Cardiovascular events are not associated with MTHFR polymorphisms, but are associated with methotrexate use and traditional risk factors in US veterans with rheumatoid arthritis.
Contribution of MTHFR gene variants in lupus related subclinical atherosclerosis.
Cost-effectiveness analysis of MTHFR polymorphism screening by polymerase chain reaction in Korean patients with rheumatoid arthritis receiving methotrexate.
Detection of six single-nucleotide polymorphisms associated with rheumatoid arthritis by a loop-mediated isothermal amplification method and an electrochemical DNA chip.
Differing effects of methylenetetrahydrofolate reductase single nucleotide polymorphisms on methotrexate efficacy and toxicity in rheumatoid arthritis.
Effect of MTHFR, TGF?1, and TNFB polymorphisms on osteoporosis in rheumatoid arthritis patients.
Genetic Polymorphisms of TYMS, MTHFR, ATIC, MTR, and MTRR Are Related to the Outcome of Methotrexate Therapy for Rheumatoid Arthritis in a Chinese Population.
High-resolution melting curve analysis for genotyping of common SNP in MTHFR gene using fixed-cell suspension.
Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis.
IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects.
Impact of MTHFR rs1801133, MTHFR rs1801131 and ABCB1 rs1045642 polymorphisms with increased susceptibility of rheumatoid arthritis in the West Algerian population: A case-control study.
Influence of MTHFR C677T gene polymorphism in the development of cardiovascular disease in Egyptian patients with rheumatoid arthritis.
Influence of MTHFR C677T polymorphism on methotrexate monotherapy discontinuation in rheumatoid arthritis patients: results from the GAPAID European project.
Lack of association between MTHFR A1298C polymorphism and outcome of methotrexate treatment in rheumatoid arthritis patients: evidence from a systematic review and meta-analysis.
Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene.
Methylene tetrahydrofolate reductase, transforming growth factor-?1 and lymphotoxin-? genes polymorphisms and susceptibility to rheumatoid arthritis.
Methylenetetrahydrofolate reductase and reduced folate carrier-1 genotypes and methotrexate serum concentrations in patients with rheumatoid arthritis.
Methylenetetrahydrofolate reductase polymorphisms, C677T and A1298C, are associated with methotrexate-related toxicities in Korean patients with rheumatoid arthritis.
MTHFR C677T, MTHFR A1298C, and OPG A163G polymorphisms in Mexican patients with rheumatoid arthritis and osteoporosis.
MTHFR functional genetic variation and methotrexate treatment response in rheumatoid arthritis: a meta-analysis.
MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms.
MTHFR gene polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis based on 16 studies.
MTHFR polymorphisms, C677T and A1298C, are not a genetic risk factor for liver stiffness index in methotrexate-treated rheumatoid arthritis patients.
MTHFR, TYMS and SLCO1B1 polymorphisms and adverse liver effects of methotrexate in rheumatoid arthritis.
MTRR A66G, RFC1 G80A, and MTHFR C677T and A1298C Polymorphisms and Disease Activity in Mexicans with Rheumatoid Arthritis Treated with Methotrexate.
No correlation between MTHFR c.677 C?>?T, MTHFR c.1298 A?>?C, and ABCB1 c.3435 C?>?T polymorphisms and methotrexate therapeutic outcome of rheumatoid arthritis in West Algerian population.
Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis.
Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheumatoid arthritis treated with methotrexate: implication with elevation of transaminases.
Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses.
Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis.
Prediction of methotrexate clinical response in Portuguese rheumatoid arthritis patients: implication of MTHFR rs1801133 and ATIC rs4673993 polymorphisms.
Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis.
Short Communication: Lack of association between MTHFR gene polymorphisms and response to methotrexate treatment in Pakistani patients with rheumatoid arthritis.
The c.1298A>C polymorphism in the methylenetetrahydrofolate reductase gene is associated with rheumatoid arthritis susceptibility in Italian patients.
The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients.
The C677T polymorphism in the MTHFR gene is associated with the toxicity of methotrexate in a Spanish rheumatoid arthritis population.
The effect of 677C>T and 1298A>C MTHFR polymorphisms on sulfasalazine treatment outcome in rheumatoid arthritis.
The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients.
The plausible association of MTHFR and ADORA2A polymorphisms with nodules in rheumatoid arthritis patients treated with methotrexate.
[Methylenetetrahydrofolate reductase polymorphisms in methotrexate treatment of rheumatoid arthritis patients. Review of the literature and personal experience.]
Asthenozoospermia
[The effect of polymorphisms C677T and 1298 gene MTHFR on the reproductive function of men].
Asthma
Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma.
Is Folate Status a Risk Factor for Asthma or Other Allergic Diseases?
Lack of association between the MTHFR (C677T) polymorphism and atopic disease.
Maternal folic acid use during pregnancy, methylenetetrahydrofolate reductase gene polymorphism, and child's lung function and asthma.
Neonatal folate, homocysteine, vitamin B12 levels and methylenetetrahydrofolate reductase variants in childhood asthma and eczema.
Relationship between MTHFR gene polymorphism and susceptibility to bronchial asthma and glucocorticoid efficacy in children.
The association between mother and child MTHFR C677T polymorphisms, dietary folate intake and childhood atopy in a population-based, longitudinal birth cohort.
[Methylenetetrahydrofolate reductase [correction of reducatase] polymorphism and asthma]
[Polymorphisms in xenobiotic-metabolizing genes in the pathogenesis of glucocorticoid-induced osteoporosis in patients with bronchial asthma].
Atherosclerosis
A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis.
An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis.
An association of 5,10-Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphism and ischemic stroke.
Assessment of tailor-made prevention of atherosclerosis with folic acid supplementation: randomized, double-blind, placebo-controlled trials in each MTHFR C677T genotype.
Association between Genetic Polymorphisms and Sites of Cervicocerebral Artery Atherosclerosis.
Association of the C677T polymorphism in the MTHFR gene with breast and/or ovarian cancer risk in Jewish women.
Associations of methylenetetrahydrofolate reductase C677T polymorphism with markers of subclinical atherosclerosis: The Cardiovascular Risk in Young Finns Study.
Atherosclerosis in male patients with ankylosing spondylitis: the relation with methylenetetrahydrofolate reductase (C677T) gene polymorphism and plasma homocysteine levels.
Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: data from the Women's Genome Health Study.
Carrier-state of D allele in ACE gene insertion/deletion polymorphism is associated with coronary artery disease, in contrast to the C677-->T transition in the MTHFR gene.
Contribution of MTHFR gene variants in lupus related subclinical atherosclerosis.
Croatian population data for the C677T polymorphism in methylenetetrahydrofolate reductase: frequencies in healthy and atherosclerotic study groups.
Effect of MTHFR Gene Polymorphism Impact on Atherosclerosis via Genome-Wide Methylation.
Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men.
Evaluation of high sensitive C-reactive protein and 5-10 methylenetetrahydrofolate reductase genotype in japanese young adults.
Expression of the C677T Polymorphism of the 5, 10-Methylenetetrahydrofolate Reductase (MTHFR) Gene in Patients with Carotid Artery Atherosclerosis.
Genetic contributors and soluble mediators in prediction of autoimmune comorbidity.
Homocysteine, endothelial dysfunction, and coronary artery disease: emerging strategy for secondary prevention.
Hypertrophy of IMC of carotid artery in Parkinson's disease is associated with L-DOPA, homocysteine, and MTHFR genotype.
Interaction between Mediterranean diet and methylenetetrahydrofolate reductase C677T mutation on oxidized low density lipoprotein concentrations: The ATTICA study.
Lack of carotid stiffening associated with MTHFR 677TT genotype in cardiorespiratory fit adults.
Metabolic factors and chronic hepatitis C: a complex interplay.
Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes.
Methylenetetrahydrofolate reductase polymorphism determines the plasma homocysteine-lowering effect of large-dose folic acid supplementation in patients with cardiovascular disease.
MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis.
MTHFR C677T mutation increased the risk of Ischemic Stroke, especially in large-artery atherosclerosis in adults: an updated meta-analysis from 38 researches.
Multiple thrombophilia mutations as a possible cause of premature myocardial infarction.
No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese.
Plasma homocyst(e)ine concentration, but not MTHFR genotype, is associated with variation in carotid plaque area.
Plasma total homocysteine and the methylenetetrahydrofolate reductase 677C>T polymorphism do not contribute to the distribution of cervico-cerebral atherosclerosis in ischaemic stroke patients.
Serum homocysteine, methylenetetrahydrofolate reductase gene polymorphism and cardiovascular disease in heterozygous familial hypercholesterolemia.
Serum total homocysteine, folate, 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T genotype and subclinical atherosclerosis.
Smoking Confers a MTHFR 677C>T Genotype-Dependent Risk for Systemic Atherosclerosis: Results from a Large Number of Elderly Autopsy Cases that Died in a Community-Based General Geriatric Hospital.
Sonographic evaluation of atherosclerosis burden in carotid arteries of ischemic stroke patients and its relation to paraoxonase 1 and 2, MTHFR and AT1R genetic variants.
The 1316T>C missenses mutation in MTHFR contributes to MTHFR deficiency by targeting MTHFR to proteasome degradation.
The effect of a common methylenetetrahydrofolate reductase mutation on levels of homocysteine, folate, vitamin B12 and on the risk of premature atherosclerosis.
The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction.
The Relationship of Methylenetetrahydrofolate Reductase Gene C677T Polymorphism and Ischemic Stroke in Chinese Han Population.
The SNP Rs915014 in MTHFR Regulated by MiRNA Associates with Atherosclerosis.
[Features of allele polymorphism of genes involved in homocysteine and folate metabolism in patients with atherosclerosis of the lower extremity arteries]
[Homocysteinemia and thrombophilic factors in unexplained decompression sickness]
[Thrombophilic factors in divers with undeserved decompression sickness.]
Atrial Fibrillation
Ischemic Stroke in a Patient With Atrial Tachycardia, Methylenetetrahydrofolate Reductase Mutation and New-Onset Atrial Fibrillation: Is Early Initiation of Anticoagulation Therapy Indicated?
Rivaroxaban as an effective alternative to warfarin in a patient with atrial fibrillation, thrombophilia, and left atrial appendage thrombus: a case report.
Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility.
The factor V Leiden, prothrombin gene 20210GA, methylenetetrahydrofolate reductase 677CT and platelet glycoprotein IIIa 1565TC mutations in patients with acute ischemic stroke and atrial fibrillation.
[Interrelationship between polymorphic markers of methylenetetrahydrofolate reductase gene and development of acute disturbance of brain circulation in families of patients with atrial fibrillation].
Autoimmune Diseases
Association of methylenetetrahydrofolate reductase gene C677T polymorphism with multiple sclerosis in Turkish patients.
Association of MTHFR C677T polymorphism with elevated homocysteine level and disease development in vitiligo.
Association study between methylenetetrahydrofolate reductase gene polymorphisms and Graves' disease.
Ill-defined neurological syndromes with autoimmune background: a diagnostic challenge.
The protective effects of the methylenetetrahydrofolate reductase rs1801131 variant among Saudi smokers.
Avitaminosis
An unusually high plasma concentration of homocysteine resulting from a combination of so-called "secondary" etiologies.
Antiepileptic drug-induced psychosis associated with MTHFR C677T: a case report.
Celiac sprue, hyperhomocysteinemia, and MTHFR gene variants.
Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life.
Effect of folate, vitamin B6, and vitamin B12 intake and MTHFR C677T polymorphism on homocysteine concentrations of renal transplant recipients.
G1793A polymorphisms in the methylene-tetrahydrofolate gene: effect of folic acid on homocysteine levels.
Azoospermia
Association between genetic polymorphisms in folate-related enzyme genes and infertile men with non-obstructive azoospermia.
Association of a miR-34b binding site single nucleotide polymorphism in the 3'-untranslated region of the methylenetetrahydrofolate reductase gene with susceptibility to male infertility.
Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with male infertility: a meta-analysis.
Association of the methylenetetrahydrofolate reductase gene C677T polymorphism with the risk of male infertility: a meta-analysis.
Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility.
Chromosomal aberration leads to recurrent pregnancy loss and partial trisomy of 5p12-15.3 in the offspring: report of a Syrian couple and review of the literature .
Evaluation of association between methylenetetrahydrofolate reductase and azoospermia: A meta-analysis.
Evaluation of association between methylenetetrahydrofolate reductase and azoospermia: A meta-analysis: Retraction.
Influence of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms in Algerian Infertile Men with Azoospermia or Severe Oligozoospermia.
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis.
Methylenetetrahydrofolate reductase C677T polymorphism and the risk of male infertility: a meta-analysis.
Methylenetetrahydrofolate reductase polymorphisms are related to male infertility in Brazilian men.
MTHFR C677T polymorphism associates with unexplained infertile male factors.
MTHFR promoter hypermethylation in testicular biopsies of patients with non-obstructive azoospermia: the role of epigenetics in male infertility.
Role of genetic mutations in folate-related enzyme genes on Male Infertility.
Single nucleotide polymorphism C677T in the methylenetetrahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia.
Bacterial Infections
Review article: the aetiology of primary Budd-Chiari syndrome - differences between the West and China.
Barrett Esophagus
Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.
Behcet Syndrome
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and variations of homocysteine concentrations in patients with Behcet's disease.
Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C).
Bell Palsy
Diagnosis and management of idiopathic facial palsy in children.
beta-Thalassemia
Atypical hemolytic uremic syndrome with peripheral gangrene and homocysteinemia in a child.
Hypercoagulable state and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with beta-thalassemia major in Kuwait.
MTHFR C677T, Prothrombin G20210A, and Factor V Leiden (G1691A) Polymorphism and Beta-Thalassemia Risk: A Meta-Analysis.
Prevalence of Factor V Leiden G1691A, MTHFR C677T, and Prothrombin G20210A Among Asian Indian Sickle Cell Patients.
Prevalence of thrombotic risk factors among beta-thalassemia patients from Western Iran.
The prevalence of factor V Leiden (G1691A), prothrombin G20210A and methylenetetrahydrofolate reductase C677T mutations in Jordanian patients with beta-thalassemia major.
Biotinidase Deficiency
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
Bladder Exstrophy
Bladder exstrophy-epispadias complex and the role of methylenetetrahydrofolate reductase C677T polymorphism: A case control study.
MTHFR 677 TT genotype in a mother and her child with Down syndrome, atrioventricular canal and exstrophy of the bladder: implications of a mutual genetic risk factor?
Bone Diseases
Study of specific genetic and epigenetic variables in multiple myeloma.
Bone Diseases, Metabolic
A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish osteoporosis prevention study.
Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C667T polymorphism, with bone mineral density in postmenopausal Iranian women: a cross-sectional study.
Bone Resorption
Association of Blood Lead Levels with Methylenetetrahydrofolate Reductase Polymorphisms among Chinese Pregnant Women in Wuhan City.
Hyperhomocysteinemia is Associated with Inflammation, Bone Resorption, Vitamin B12 and Folate Deficiency and MTHFR C677T Polymorphism in Postmenopausal Women with Decreased Bone Mineral Density.
Brain Diseases
Adolescence/adult onset MTHFR deficiency may manifest as isolated and treatable distinct neuro-psychiatric syndromes.
Betaine for treatment of homocystinuria caused by methylenetetrahydrofolate reductase deficiency.
Clinical presentation, etiology, and outcome of stroke in children: A hospital-based study.
Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.
Genetic polymorphisms associated with 5-Fluorouracil-induced neurotoxicity.
Intermittent encephalopathy, reversible nerve conduction slowing, and MRI evidence of cerebral white matter disease in methylenetetrahydrofolate reductase deficiency.
Methylenetetrahydrofolate reductase (MTHFR) deficiency and infantile epilepsy.
Pearls & oy-sters: familial epileptic encephalopathy due to methylenetetrahydrofolate reductase deficiency.
[Cystathionine betasynthase and MTHFR deficiencies in adults]
[Genotype and phenotype analysis of neonates with neonatal encephalopathy complicated with perinatal hypoxic event].
Brain Infarction
Association of methylenetetrahydrofolate reductase (MTHFR 677C>T and 1298A>C) polymorphisms and haplotypes with silent brain infarction and homocysteine levels in a Korean population.
Effect of methylenetetrahydrofolate reductase gene polymorphisms and oxidative stress in silent brain infarction.
Homozygous MTHFR C677T gene mutation and recurrent stroke in an infant.
Hyperhomocysteinemia as an independent risk factor for silent brain infarction.
MTHFR C677T and prothrombin G20210A mutations in a woman from Dalmatia with silent brain infarction. .
MTHFR gene polymorphism as a risk factor for silent brain infarcts and white matter lesions in the Japanese general population: The NILS-LSA Study.
[Study on homocysteine metabolism related enzymes gene mutations in Chinese patients with ischemic cardiovascular and cerebrovascular diseases]
Brain Injuries
Maternal mutation 677C > T in the methylenetetrahydrofolate reductase gene associated with severe brain injury in offspring.
Brain Injuries, Traumatic
Pathomorphology of inflammatory response following traumatic brain injury, serum values of interleukins, and gene polymorphisms.
Brain Ischemia
Methylenetetrahydrofolate reductase gene polymorphisms in patients with cerebral hemorrhage.
Risk factors of cerebral ischemia in infants born to mothers with gestational diabetes.
[A clinical and genetic analysis of risk factors for the development of acute and chronic cerebral ischemia].
Brain Neoplasms
Association of the MTHFR C677T polymorphism with primary brain tumor risk.
C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and high-grade gliomas.
Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma.
Intranasal perillyl alcohol therapy improves survival of patients with recurrent glioblastoma harboring mutant variant for MTHFR rs1801133 polymorphism.
MTHFR single nucleotide polymorphism associated with working memory in pediatric medulloblastoma survivors.
Polymorphisms of Folate Pathway Enzymes (Methylenetetrahydrofolate Reductase and Thymidylate Synthase) and Their Relationship with Thymidylate Synthase Expression in Human Astrocytic Tumors.
Risk association of meningiomas with MTHFR C677T and GSTs polymorphisms: a meta-analysis.
Breast Diseases
Breast cancer risk and methylenetetrahydrofolate reductase polymorphism.
Breast Neoplasms
A candidate CpG SNP approach identifies a breast cancer associated ESR1-SNP.
A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in breast cancer.
Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer.
Alcohol consumption and genetic variation in methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk.
Association Analysis of Methylenetetrahydrofolate Reductase Common Gene Polymorphisms with Breast Cancer Risk in an Iranian Population: A Case-Control Study and a Stratified Analysis.
Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer.
Association between dietary intake of folate, vitamin B6, B12 & MTHFR, MTR Genotype and breast cancer risk.
Association between MTHFR 677C/T and 1298A/C gene polymorphisms and breast cancer risk.
Association between MTHFR gene 1298A>C polymorphism and breast cancer susceptibility: a meta-analysis based on 38 case-control studies with 40,985 subjects.
Association between the MTHFR C677T Polymorphism and Breast Cancer Risk: A Meta-Analysis of 23 Case-Control Studies.
Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies.
Association of 677 C>T (rs1801133) and 1298 A>C (rs1801131) polymorphisms in the MTHFR gene and breast cancer susceptibility: a meta-analysis based on 57 individual studies.
Association of C677T (rs1081133) and A1298C (rs1801131) Methylenetetrahydrofolate Reductase Variants with Breast Cancer Susceptibility Among Asians: A Systematic Review and Meta-Analysis.
Association of dietary intake of folate and MTHFR genotype with breast cancer risk.
Association of dietary intake of folate, vitamin B6 and B12 and MTHFR genotype with breast cancer risk.
Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma.
Association of Intake Folate and Related Gene Polymorphisms with Breast Cancer.
Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B6, and vitamin B 12 intakes.
Association of MTHFR (C677T) Gene Polymorphism With Breast Cancer in North India.
ASSOCIATION OF MTHFR A1298C POLYMORPHISM WITH BREAST CANCER AND/OR OVARIAN CANCER RISK: AN UPDATED META-ANALYSIS.
Association of MTHFR gene polymorphisms with breast cancer survival.
Association of physical activity and polymorphisms in FGFR2 and DNA methylation related genes with breast cancer risk.
Association of polymorphisms in one-carbon metabolizing genes with breast cancer risk in Syrian women.
Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population.
Association of the MTHFR Gene C677T Polymorphism with Breast Cancer in a Turkish Population.
Associations of polymorphisms of folate cycle enzymes and risk of breast cancer in a Brazilian population are age dependent.
Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort.
Breast cancer risk and methylenetetrahydrofolate reductase polymorphism.
Breast cancer risk associated with gene expression and genotype polymorphisms of the folate-metabolizing MTHFR gene: a case-control study in a high altitude Ecuadorian mestizo population.
Breast cancer risk, dietary intake, and methylenetetrahydrofolate reductase (MTHFR)single nucleotide polymorphisms.
C677T and A1298C methylenetetrahydrofolate reductase polymorphisms and breast cancer susceptibility among Latinos: a meta-analysis.
Can MTHFR C677T and A1298C Polymorphisms Alter the Risk and Severity of Sporadic Breast Cancer in Brazilian Women?
Combined impact of polymorphism of folate metabolism genes; glutamate carboxypeptidase, methylene tetrahydrofolate reductase and methionine synthase reductase on breast cancer susceptibility in kashmiri women.
Controversial roles of methylenetetrahydrofolate reductase polymorphisms and folate in breast cancer disease.
Cumulative review and meta-analyses on the association between MTHFR rs1801133 polymorphism and breast cancer risk: a pooled analysis of 83 studies with 74,019 participants.
Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan.
Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women.
Dihydrofolate reductase (DHRF) 19-bp intron-1 deletion and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms in breast cancer.
Distribution of TYMS, MTHFR, p53 and MDR1 gene polymorphisms in patients with breast cancer treated with neoadjuvant chemotherapy.
DNA promoter methylation in breast tumors: no association with genetic polymorphisms in MTHFR and MTR.
Do single nucleotide polymorphisms in xenobiotic metabolizing genes determine breast cancer susceptibility and treatment outcomes?
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.
Effect of the methylenetetrahydrofolate reductase gene C677T polymorphism on C-erbB-2 methylation status and its association with cancer.
Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities.
Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer.
Evaluation of the contribution of methylenetetrahydrofolate reductase genotypes to Taiwan breast cancer.
Evaluation of the two polymorphisms rs1801133 in MTHFR and rs10811661 in CDKN2A/B in breast cancer.
Evidence of Association Between Methylenetetrahydrofolate Reductase Gene and Susceptibility to Breast Cancer: A Candidate-Gene Association Study in a South-Eastern European Population.
Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast.
Factor V Leiden, prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms and the risk of tamoxifen-associated thromboembolism in breast cancer patients.
Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR).
Folate intake, methylenetetrahydrofolate reductase polymorphisms, and breast cancer risk in women from the Malmö Diet and Cancer cohort.
Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: a case-control study.
Generalized Multifactor Dimensionality Reduction (GMDR) Analysis of Drug-Metabolizing Enzyme-Encoding Gene Polymorphisms may Predict Treatment Outcomes in Indian Breast Cancer Patients.
Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma.
Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analyses.
Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan.
Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer.
Genetic testing costs and compliance with clinical best practices.
Germ-line MTHFR C677T, FV H1299R and PAI-1 5G/4G Variations in Breast Carcinoma.
Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study.
Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study.
GSTP1 and MTHFR polymorphisms are related with toxicity in breast cancer adjuvant anthracycline-based treatment.
Haplotypes of the MTHFR gene are associated with an increased risk of breast cancer in a Han Chinese population in Gansu province.
HFE, MTHFR, and FGFR4 genes polymorphisms and breast cancer in Brazilian women.
Homozygosity at the C677T of the MTHFR gene is associated with increased breast cancer risk in the Turkish population.
Increased breast cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele.
Influence of chemotherapeutic drug-related gene polymorphisms on toxicity and survival of early breast cancer patients receiving adjuvant chemotherapy.
Influence of Estrogenic Metabolic Pathway Genes Polymorphisms on Postmenopausal Breast Cancer Risk.
Influence of thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms on the disease-free survival of breast cancer patients receiving adjuvant 5-fluorouracil/methotrexate-based therapy.
Interaction of MTHFR C677T and A1298C, and MTR A2756G gene polymorphisms in breast cancer risk in a population in Northeast Brazil.
Interactions Between MTHFR C677T - A1298C Variants and Folic Acid Deficiency Affect Breast Cancer Risk in a Chinese Population.
Investigation of Methylenetetrahydrofolate Reductase C677T Polymorphism and Human Papilloma Virus Genotypes in Iranian Breast Cancer.
Joint effects between urinary selenium and polymorphisms in methylation related genes on breast cancer risk.
Joint effects of folate intake and one-carbon-metabolizing genetic polymorphisms on breast cancer risk: a case-control study in China.
Lack of association between methylenetetrahydrofolate reductase gene A1298C polymorphism and breast cancer susceptibility.
Lack of association between methylenetetrahydrofolate reductase genetic polymorphisms and postmenopausal breast cancer risk.
Lack of association between MHTFR Glu429Ala polymorphism and breast cancer susceptibility: a systematic review and meta-analysis of 29 research studies.
Lack of association between MTHFR C677T polymorphism and breast cancer risk in Ahvaz, west south-Iran.
Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk.
Methionine-Dependence Phenotype in the de novo Pathway in BRCA1 and BRCA2 Mutation Carriers with and without Breast Cancer.
Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis.
Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in breast cancer: a Sardinian preliminary case-control study.
Methylenetetrahydrofolate Reductase A1298C Polymorphism and Breast Cancer Risk: A Meta-analysis of 33 Studies.
Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype.
Methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Moroccan women.
Methylenetetrahydrofolate reductase C677T polymorphism in breast cancer risk.
Methylenetetrahydrofolate reductase gene and susceptibility to breast cancer: a meta-analysis.
Methylenetetrahydrofolate reductase gene C677T polymorphism and breast cancer risk: Evidence for genetic susceptibility.
Methylenetetrahydrofolate reductase haplotype tag single-nucleotide polymorphisms and risk of breast cancer.
Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer.
Methylenetetrahydrofolate reductase polymorphism, diet, and breast cancer in Korean women.
Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk in Chinese population: a meta-analysis of 22 case-control studies.
Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls.
MTHFR 677C>T polymorphism and the risk of breast cancer: evidence from an original study and pooled data for 28031 cases and 31880 controls.
MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review.
MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study.
MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls.
MTHFR gene A1298C polymorphisms are associated with breast cancer risk among Chinese population: evidence based on an updated cumulative meta-analysis.
MTHFR gene polymorphism and severe toxicity during adjuvant treatment of early breast cancer with cyclophosphamide, methotrexate, and fluorouracil (CMF)
MTHFR Gene Polymorphism-Mutations and Air Pollution as Risk Factors for Breast Cancer: A Metaprediction Study.
MTHFR genotypes and breast cancer survival after surgery and chemotherapy: a report from the Shanghai Breast Cancer Study.
MTHFR polymorphisms and breast cancer risk.
MTHFR polymorphisms, diet, HRT, and breast cancer risk: the multiethnic cohort study.
MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women.
MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study.
MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: a case-control study in a population from North Sardinia.
Multiple Genetic Polymorphisms of GSTP1 313AG, MDR1 3435CC, and MTHFR 677CC highly correlated with early relapse of breast cancer patients in Taiwan.
Mutational analysis of the MTHFR gene in breast cancer patients of Pakistani population.
No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study.
No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer.
One-carbon metabolism and breast cancer risk: no association of MTHFR, MTR, and TYMS polymorphisms in the GENICA study from Germany.
One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer.
One-carbon metabolism-related gene polymorphisms and risk of breast cancer.
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Pharmacogenetics of capecitabine in advanced breast cancer patients.
Plasma B-vitamins and one-carbon metabolites and the risk of breast cancer in younger women.
Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan.
Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer.
Polymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese population.
Polymorphisms in the MTHFR gene are associated with breast cancer.
Polymorphisms in the MTHFR gene are associated with recurrence risk in lymph node-positive breast cancer patients.
Polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and thymidylate synthase enhancer region (TSER) as a risk factor of cholangiocarcinoma in a Korean population.
Polymorphisms of MTHFR and TYMS predict capecitabine-induced hand-foot syndrome in patients with metastatic breast cancer.
Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study.
Population-level diversity in the association of genetic polymorphisms of one-carbon metabolism with breast cancer risk.
Preventive medical services not covered by public health insurance at Daiko Medical Center in Japan, 2004-2011.
Reduced breast cancer risk with increasing serum folate in a case-control study of the C677T genotype of the methylenetetrahydrofolate reductase gene.
Relationship between Genetic Polymorphisms in MTHFR (C677T, A1298C and their Haplotypes) and the Incidence Of Breast Cancer among Jordanian Females--Case-Control Study.
Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response.
Relationship of MTHFR and NQO1 Pharmacogenetics and Chemotherapy Clinical Outcomes in Breast Cancer Patients.
Retraction notice to Breast Cancer Risk, Dietary Intake, and Methylenetetrahydrofolate reductase (MTHFR) Single Nucleotide Polymorphisms Food and Chemical Toxicology 48/7 (2010) 1881 - 1885.
Role of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies.
Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development.
Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study.
Strong Correlation of MTHFR Gene Polymorphisms with Breast Cancer and its Prognostic Clinical Factors among Egyptian Females.
The association between methylenetetrahydrofolate reductase 677C>T polymorphisms and breast cancer susceptibility: A meta-analysis based on Chinese Han population.
The association between methylenetetrahydrofolate reductase gene C677T polymorphisms and breast cancer risk in Chinese population.
The association of p53 mutations and p53 codon 72, Her 2 codon 655 and MTHFR C677T polymorphisms with breast cancer in Northern Greece.
The Association of Protease Activated Receptor 1 gene -506 I/D Polymorphism with Disease-Free Survival in Breast Cancer Patients.
The common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk.
The effect of folate-related SNPs on clinicopathological features, response to neoadjuvant treatment and survival in pre- and postmenopausal breast cancer patients.
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China.
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.
The methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Asian populations.
The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan.
Thrombophilic polymorphisms are not associated with disease-free survival in breast cancer patients.
TYMS, MTHFR, p53 and MDR1 gene polymorphisms in breast cancer patients treated with adjuvant therapy.
[Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of breast cancer]
[C677T-SNP of methylenetetrahydrofolate reductase gene and breast cancer in Mexican women].
[MTHFR polymorphisms, dietary folate intake and risks to breast cancer]
[Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia].
Budd-Chiari Syndrome
Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors - a multicentre case-control study. For the Childhood Thrombophilia Study Group.
Association of factor V Leiden, Janus kinase 2, prothrombin, and MTHFR mutations with primary Budd-Chiari syndrome in Egyptian patients.
Budd-Chiari syndrome in a paroxysmal nocturnal hemoglobinuria patient with coexistence of factor II and MTHFR mutations.
Budd-Chiari syndrome with underlying homozygous factor V Leiden and heterozygous methylenetetrahydrofolate reductase mutations.
Compound heterozygosity for factor V and methylenetetrahydrofolate reductase mutations in a patient with Budd-Chiari syndrome.
Hyperhomocysteinemia and the MTHFR C677T mutation in Budd-Chiari syndrome.
Methylenetetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia in Budd-Chiari syndrome and portal vein thrombosis: A systematic review and meta-analysis of observational studies.
CADASIL
A Patient with Combined CADASIL and MTHFR Homozygosity.
Carcinogenesis
A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.
A case-control study of methylenetetrahydrofolate reductase polymorphisms in cervical carcinogenesis.
A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma.
Analysis of relation between C677T genotype in MTHFR gene and prostatic cancer in Iranian males.
Are the methylenetetrahydrofolate reductase 1298 and 677 gene polymorphisms related to optic glioma and hamartoma risk in neurofibromatosis type 1 patients?
Association between methylenetetrahydrofolate reductase polymorphism C677T and risk of chronic myeloid leukemia in Serbian population.
Association between methylenetetrahydrofolate reductase polymorphisms, alcohol intake and oropharyngolaryngeal carcinoma in northern Italy.
Association between MTHFR C677T, MTHFR A1298C and MS A2756G polymorphisms and risk of cervical intraepithelial neoplasia II/III and cervical cancer: A meta-analysis.
Association between polymorphisms of folate-metabolizing enzymes and risk of prostate cancer.
Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population.
Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.
Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy.
Association of the MTHFR C677T polymorphism with primary brain tumor risk.
Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations.
Distribution of p53, GST, and MTHFR polymorphisms and risk of cervical intraepithelial lesions in sicily.
Emerging Role of Polymorphisms of the MTHFR Gene in Systemic Carcinogenesis Besides Their Role in Migraines.
Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis.
Folate metabolism-related gene polymorphisms and susceptibility to primary liver cancer in North China.
Folic acid, polymorphism of methyl-group metabolism genes, and DNA methylation in relation to GI carcinogenesis.
Genetic polymorphisms of methylenetetrahydrofolate reductase and aldehyde dehydrogenase 2, alcohol use and risk of colorectal adenomas: Self-Defense Forces Health Study.
Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East.
Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan.
Impact of methylenetetrahydrofolate reductase (MTHFR) codon (677) and methionine synthase (MS) codon (2756) on risk of cervical carcinogenesis in North Indian population.
Impact of the MTHFR C677T polymorphism on colorectal cancer in a population with low genetic variability.
Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.
Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review.
Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer.
Methylenetetrahydrofolate reductase (MTHFR) genotype, smoking habit, metastasis and oral cancer in Taiwan.
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and risk of proximal colon cancer in north Italy.
Methylenetetrahydrofolate Reductase C677T Polymorphism and Cervical Cancer Risk: a Meta-Analysis.
Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice.
Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphisms association with the risk of diffuse large B cell lymphoma: a meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphisms association with the risk of follicular lymphoma: a meta-analysis.
Methylenetetrahydrofolate reductase genotype does not play a role in multiple myeloma pathogenesis.
Methylenetetrahydrofolate reductase polymorphism and minor increase of risk for oral cancer.
Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas.
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.
Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population.
Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis.
MTHFR 677CC/1298CC genotypes are highly associated with chronic myelogenous leukemia: a case-control study in Korea.
MTHFR A1298C and C677T gene polymorphisms and susceptibility to chronic myeloid leukemia in Egypt.
MTHFR C677T and A1298C polymorphisms were associated with bladder cancer risk and disease progression: a meta-analysis.
MTHFR C677T polymorphism and anatomopathological characteristics with prognostic significance in sporadic colorectal cancer.
MTHFR C677T polymorphism and pancreatic cancer risk: a meta-analysis.
MTHFR C677T polymorphism contributes to colorectal cancer susceptibility: evidence from 61 case-control studies.
MTHFR C677T polymorphism contributes to the risk for gastric cancer.
MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: A meta-analysis.
MTHFR Knockdown Assists Cell Defense against Folate Depletion Induced Chromosome Segregation and Uracil Misincorporation in DNA.
MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene-environment interactions in colorectal tumorigenesis.
MTHFR Polymorphisms and Opisthorchis viverrini Infection: a Relationship with Increased Susceptibility to Cholangiocarcinoma in Thailand.
Pancreaticobiliary cancers with deficient methylenetetrahydrofolate reductase genotypes.
Polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and risk of head and neck squamous cell carcinoma.
Polymorphisms in one-carbon metabolism pathway genes, urinary arsenic profile, and urothelial carcinoma.
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of gastric cancer in a Chinese population: a case-control study.
Polymorphisms of methylenetetrahydrofolate reductase and methionine synthase genes and bladder cancer risk: a case-control study with meta-analysis.
Polymorphisms of methylenetetrahydrofolate reductase are associated with a high risk of nasopharyngeal carcinoma in a smoking population from Southern China.
Positive association between MTHFR C677T polymorphism and oral cancer risk: a meta-analysis.
Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency.
Relationship between the Methylation of Folic Acid Metabolism-Related Genes and the Incidence and Prognosis of Esophageal Cancer among Ethnic Kazakhs.
Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.
Role of MTHFR C677T polymorphism in systemic carcinogenesis, besides its role in the pathogenesis of colo-rectal carcinomas.
Role of MTHFR polymorphisms and folate levels in different phenotypes of sporadic colorectal cancers.
Susceptibility to gastric cardia adenocarcinoma and genetic polymorphisms in methylenetetrahydrofolate reductase in an at-risk Chinese population.
The effect of methylenetetrahydrofolate reductase polymorphism C677T on cervical cancer in Korean women.
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China.
The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lymphocytes.
The polymorphism of methylenetetrahydrofolate reductase C677T but not A1298C contributes to gastric cancer.
Tyms double (2R) and triple repeat (3R) confers risk for human oral squamous cell carcinoma.
[No association between MTHFR 677C>T polymorphism and ovarian cancer risk in BRCA1 mutation carriers in Wielkopolska region].
[Single nucleotide polymorphisms in methylenetetrahydrofolate reductase gene and susceptibility to cancer of the gastric cardia in Chinese population]
Carcinoma
Aberrant DNA Methylation associated with MTHFR C677T Genetic Polymorphism in cutaneous squamous cell carcinoma in renal transplant patients.
Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism and folate intake in esophageal squamous cell carcinoma.
Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism in esophageal squamous cell carcinoma.
Aberrant methylated key genes of methyl group metabolism within the molecular etiology of urothelial carcinogenesis.
Allelic variations in 5, 10-methylenetetrahydrofolate reductase gene and susceptibility to cervical cancer in Indian women.
An enhanced risk of basal cell carcinoma is associated with particular polymorphisms in the VDR and MTHFR genes.
Analysis of relation between C677T genotype in MTHFR gene and prostatic cancer in Iranian males.
Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour lines.
Application of microarray-based method for methylenetetrahydrofolate reductase (MTHFR) polymorphisms in the risk of gastric carcinoma in east China population.
Association between a microRNA-214 binding site polymorphism in the methylenetetrahydrofolate reductase gene and esophageal squamous cell carcinoma.
Association between dietary folate intake and clinical outcome in head and neck squamous cell carcinoma.
Association between methylenetetrahydrofolate reductase polymorphisms, alcohol intake and oropharyngolaryngeal carcinoma in northern Italy.
Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.
Association of methylenetetrahydrofolate reductase polymorphism and the risk of squamous cell carcinoma in renal transplant patients.
Association of Methylenetetrahydrofolate Reductase, Vitamin D Receptor, and Interleukin-16 Gene Polymorphisms With Renal Cell Carcinoma Risk.
Association of the polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma.
Cancer-testis gene expression is associated with the methylenetetrahydrofolate reductase 677 C>T polymorphism in non-small cell lung carcinoma.
Clinicopathologic features and genetic alterations in endometrioid carcinoma of the uterus with villoglandular differentiation.
Diet folate, DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma.
Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer.
Folate intake, methylenetetrahydrofolate reductase polymorphisms in association with the prognosis of esophageal squamous cell carcinoma.
Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis.
Gender-specific association of methylenetetrahydrofolate reductase genotype and haplotype with the aggressiveness and prognosis of clear cell renal cell carcinoma in Japanese patients.
Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review).
Genetic polymorphisms in folate- metabolizing enzymes and risk of gastroesophageal cancers: a potential nutrient-gene interaction in cancer development.
Genetic susceptibility of methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C, and G1793A polymorphisms with risk for bladder transitional cell carcinoma in men.
Genetic Variants in MTHFR Gene Predict ? 2 Radiation Pneumonitis in Esophageal Squamous Cell Carcinoma Patients Treated with Thoracic Radiotherapy.
Genetic variations in MTHFR and esophageal squamous cell carcinoma susceptibility in Chinese Han population.
Head and neck cancer susceptibility: a genetic marker in the methylenetetrahydrofolate reductase gene.
Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study.
In human alleles specific variation of MTHFR C677T and A1298C associated "risk factor" for the development of ovarian cancer.
Influence of methylenetetrahydrofolate reductase polymorphisms in oral cancer patients.
Loss of heterozygosity of methylenetetrahydrofolate reductase in colon carcinomas.
Methyl group metabolism gene polymorphisms and susceptibility to prostatic carcinoma.
Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T, A1298C and G1793A Polymorphisms: Association with Risk for Clear Cell Renal Cell Carcinoma and Tumour Behaviour in Men.
Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms in oral squamous cell carcinoma in south-east Iran.
Methylenetetrahydrofolate reductase C677T polymorphism and predisposition towards esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population.
Methylenetetrahydrofolate reductase gene polymorphisms and the risk of colorectal carcinoma in a sample of Egyptian individuals.
Methylenetetrahydrofolate Reductase Genetic Polymorphisms and Esophageal Squamous Cell Carcinoma Susceptibility: A Meta-analysis of Case-control Studies.
Methylenetetrahydrofolate reductase genetic polymorphisms and esophageal squamous cell carcinoma susceptibility: A meta-analysis of case-control studies.
Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis.
Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population.
MTHFR C677T and A1298C polymorphisms and cervical carcinoma susceptibility: meta-analyses based on 4421 individuals.
MTHFR C677T and A1298C polymorphisms as predictors of radiotherapy response in head and neck squamous cell carcinoma.
MTHFR C677T genetic polymorphism in combination with serum vitamin B2, B12 and aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and esophageal precancerous lesions: a case-control study.
MTHFR C677T polymorphism interaction with heavy alcohol consumption increases head and neck carcinoma risk.
MTHFR C677T polymorphisms are associated with aberrant methylation of the IGF-2 gene in transitional cell carcinoma of the bladder.
Polymorphic methyl group metabolism genes in patients with transitional cell carcinoma of the urinary bladder.
Polymorphism in ADH and MTHFR genes in oral squamous cell carcinoma of Indians.
Polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and risk of head and neck squamous cell carcinoma.
Polymorphisms and haplotypes in methylenetetrahydrofolate reductase gene and head and neck squamous cell carcinoma risk.
Polymorphisms in the MTHFR and VDR genes and skin cancer risk.
Polymorphisms of MTHFR and susceptibility to oesophageal adenocarcinoma in a Caucasian United Kingdom population.
Polymorphisms of MTHFR C677T and A1298C association with oral carcinoma risk: a meta-analysis.
Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract.
Quantitative assessment of the effect of MTHFR polymorphisms on the risk of lung carcinoma.
Relationships among MTHFR a1298c gene polymorphisms and methylation status of Dact1 gene in transitional cell carcinomas.
Renal cell carcinoma risk is associated with the interactions of APOE, VHL and MTHFR gene polymorphisms.
Role of MTHFR C677T polymorphism in systemic carcinogenesis, besides its role in the pathogenesis of colo-rectal carcinomas.
Serum folate, MTHFR C677T polymorphism and esophageal squamous cell carcinoma risk.
Smoking and polymorphisms in folate metabolizing genes and their effects on the histological stage and grade for bladder tumors.
Systematic Review on the Relationship between Genetic Polymorphisms of Methylenetetrahydrofolate Reductase and Esophageal Squamous Cell Carcinoma.
The association between MTHFR gene polymorphisms (C677T, A1298C) and oral squamous cell carcinoma: A systematic review and meta-analysis.
The combination of methylenehydrofolate reductase C677T polymorphism screening and gastrointestinal tumor markers detection may be an early screening method for gastrointestinal cancer related to helicobacter pylori infection.
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: the Croatian case-control study.
[Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of laryngeal squamous cell carcinoma]
[Correlation of aberrant methylation of MGMT gene to MTHFR C677T genetic polymorphisms in esophageal squamous cell carcinoma]
[Relationship of methylenetetrahydrofolate reductase C677T polymorphism and chemosensitivity to 5-fluorouracil in gastric carcinoma]
Carcinoma, Basal Cell
An enhanced risk of basal cell carcinoma is associated with particular polymorphisms in the VDR and MTHFR genes.
Polymorphisms in the MTHFR and VDR genes and skin cancer risk.
Carcinoma, Ehrlich Tumor
The NADP-dependent trifunctional methylenetetrahydrofolate dehydrogenase purified from mouse liver is immunologically distinct from the mouse NAD-dependent [corrected] bifunctional enzyme.
Carcinoma, Hepatocellular
Association between methylenetetrahydrofolate reductase tagging polymorphisms and susceptibility of hepatocellular carcinoma: a case-control study.
Association between MTHFR A1298C polymorphism and hepatocellular carcinoma risk.
Association between the methylenetetrahydrofolate reductase C677T polymorphism and hepatocellular carcinoma risk: a meta-analysis.
Associations between methylenetetrahydrofolate reductase polymorphisms and hepatocellular carcinoma risk in Chinese population.
Correlation between Methylenetetrahydrofolate Reductase Polymorphisms and Hepatocellular Carcinoma: A Meta-Analysis.
Correlation Between MTHFR Polymorphisms and Hepatocellular Carcinoma: A Meta-analysis.
Genetic Polymorphism of MTHFR C677T Influences Susceptibility to HBV-Related Hepatocellular Carcinoma in a Chinese Population: a Case-Control Study.
Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma.
Meta-analysis of MTHFR C677T and A1298C gene polymorphisms: Association with the risk of hepatocellular carcinoma.
Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms as risk factors for hepatocellular carcinoma in a Korean population.
Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population.
Methylenetetrahydrofolate reductase C677T (Ala>Val, rs1801133 C>T) polymorphism decreases the susceptibility of hepatocellular carcinoma: a meta-analysis involving 12,628 subjects.
MTHFR C677T polymorphism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption.
MTHFR C677TT, PAI1 4G-4G, V Leiden Q506, and prothrombin G20210A in hepatocellular carcinoma with and without portal vein thrombosis.
MTHFR Knockdown Assists Cell Defense against Folate Depletion Induced Chromosome Segregation and Uracil Misincorporation in DNA.
Significant association between MTHFR C677T polymorphism and hepatocellular carcinoma risk: a meta-analysis.
Significant association between the MTHFR A1298C polymorphism and hepatocellular carcinoma risk: a meta-analysis.
The Association between MTHFR Gene Polymorphisms and Hepatocellular Carcinoma Risk: A Meta-Analysis.
The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis.
The MTHFR polymorphism affect the susceptibility of HCC and the prognosis of HCC liver transplantation.
[A study on the association of MTHFR C677T polymorphism with genetic susceptibility to hepatocellular carcinoma.]
Carcinoma, Non-Small-Cell Lung
Cancer-testis gene expression is associated with the methylenetetrahydrofolate reductase 677 C>T polymorphism in non-small cell lung carcinoma.
Correlation Between Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphisms and Pemetrexed Chemotherapy Efficacy/Toxicity in Non-Squamous Non-Small Cell Lung Cancer.
Heterozygote advantage of methylenetetrahydrofolate reductase polymorphisms on clinical outcomes in advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy.
Hierarchical clustering of lung cancer cell lines using DNA methylation markers.
Influence of methylenetetrahydrofolate reductase C677T polymorphism on the risk of lung cancer and the clinical response to platinum-based chemotherapy for advanced non-small cell lung cancer: an updated meta-analysis.
Methylenetetrahydrofolate reductase C677T polymorphism predicts response and time to progression to gemcitabine-based chemotherapy for advanced non-small cell lung cancer in a Chinese Han population.
Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer.
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Polymorphisms in thymidylate synthase and reduced folate carrier (SLC19A1) genes predict survival outcome in advanced non-small cell lung cancer patients treated with pemetrexed-based chemotherapy.
[Genetic polymorphisms in methylenetetrahydrofolate reductase and clinical response to chemotherapy in non-small cell lung cancer.]
Carcinoma, Renal Cell
Association of Methylenetetrahydrofolate Reductase, Vitamin D Receptor, and Interleukin-16 Gene Polymorphisms With Renal Cell Carcinoma Risk.
Gender-specific association of methylenetetrahydrofolate reductase genotype and haplotype with the aggressiveness and prognosis of clear cell renal cell carcinoma in Japanese patients.
Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T, A1298C and G1793A Polymorphisms: Association with Risk for Clear Cell Renal Cell Carcinoma and Tumour Behaviour in Men.
Renal cell carcinoma risk is associated with the interactions of APOE, VHL and MTHFR gene polymorphisms.
Carcinoma, Squamous Cell
Aberrant DNA Methylation associated with MTHFR C677T Genetic Polymorphism in cutaneous squamous cell carcinoma in renal transplant patients.
Allelic variations in 5, 10-methylenetetrahydrofolate reductase gene and susceptibility to cervical cancer in Indian women.
Association between dietary folate intake and clinical outcome in head and neck squamous cell carcinoma.
Association of methylenetetrahydrofolate reductase polymorphism and the risk of squamous cell carcinoma in renal transplant patients.
Head and neck cancer susceptibility: a genetic marker in the methylenetetrahydrofolate reductase gene.
Meta-analysis on MTHFR polymorphism and lung cancer susceptibility in East Asian populations.
Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis.
MTHFR C677T and A1298C polymorphisms as predictors of radiotherapy response in head and neck squamous cell carcinoma.
Polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and risk of head and neck squamous cell carcinoma.
Polymorphisms and haplotypes in methylenetetrahydrofolate reductase gene and head and neck squamous cell carcinoma risk.
Polymorphisms in the MTHFR and VDR genes and skin cancer risk.
Carcinoma, Transitional Cell
Genetic susceptibility of methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C, and G1793A polymorphisms with risk for bladder transitional cell carcinoma in men.
MTHFR C677T polymorphisms are associated with aberrant methylation of the IGF-2 gene in transitional cell carcinoma of the bladder.
Polymorphic methyl group metabolism genes in patients with transitional cell carcinoma of the urinary bladder.
Relationships among MTHFR a1298c gene polymorphisms and methylation status of Dact1 gene in transitional cell carcinomas.
Cardiomyopathy, Hypertrophic
Prevalence and clinical implications of hyperhomocysteinaemia in patients with hypertrophic cardiomyopathy and MTHFR C6777T polymorphism.
Cardiovascular Diseases
A common mutation in the methylenetetrahydrofolate reductase gene (C677T) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V:Q506).
A novel multiplex PCR-RFLP method for simultaneous detection of the MTHFR 677 C > T, eNOS +894 G > T and - eNOS -786 T > C variants among Malaysian Malays.
A plasma proteomics method reveals links between ischemic stroke and MTHFR C677T genotype.
A possible genetic link between MTHFR genotype and smoking behavior.
A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk.
An association between the methylenetetrahydrofolate reductase (MTHFR) C677T mutation and inflammation markers related to cardiovascular disease.
An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease.
Analysis of two mutations in the MTHFR gene associated with mild hyperhomocysteinaemia--heterogeneous distribution in the South African population.
Antiepileptic drugs, hyperhomocysteinemia and B-vitamins supplementation in patients with epilepsy.
Apolipoprotein E and methylenetetrahydrofolate reductase genetic polymorphisms in relation to other risk factors for cardiovascular disease in UK Caucasians and Black South Africans.
Are the methylenetetrahydrofolate reductase 1298 and 677 gene polymorphisms related to optic glioma and hamartoma risk in neurofibromatosis type 1 patients?
Association between polymorphism of MTHFR c.677C>T and risk of cardiovascular disease in Turkish population: a meta-analysis for 2.780 cases and 3.022 controls.
Association of Methylenetetrahydrofolate Reductase C677T and Cystathionine β-Synthase Polymorphisms in Cardiovascular Disease in the Algerian Population.
Association of methylenetetrahydrofolate reductase gene (C677T) with the risk of hypertension in Morocco.
Association of serum VLDL level with hyperhomocysteinemia in hypertensive patients: A cross-sectional study.
Atherosclerosis in male patients with ankylosing spondylitis: the relation with methylenetetrahydrofolate reductase (C677T) gene polymorphism and plasma homocysteine levels.
Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial.
C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses.
C677T polymorphism of the MTHFR gene and variant hemoglobins: a study in newborns from Salvador, Bahia, Brazil.
Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics.
Characterization of a pseudogene for murine methylenetetrahydrofolate reductase.
Common mutation in the methylenetetrahydrofolate reductase gene offers no support for mild hyperhomocysteinemia being a causal risk factor for cardiovascular disease.
Comparison of Capillary Electrophoresis, AGE, and PAGE for MTHFR Polymorphism Analysis in FFPE Cervical Samples.
Correlations of MTHFR 677C>T polymorphism with cardiovascular disease in patients with end-stage renal disease: a meta-analysis.
Does the MTHFR C677T gene polymorphism indicate cardiovascular disease risk in type 2 diabetes mellitus patients?
Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects.
Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men.
Endothelial nitric oxide synthetase, methylenetetrahydrofolate reductase polymorphisms, and cardiovascular complications in Tunisian patients with nondiabetic renal disease.
Epigenetics in Clinical Practice: Characterizing Patient and Provider Experiences with MTHFR Polymorphisms and Methylfolate.
Evaluation of Factor V G1691A, prothrombin G20210A, Factor XIII V34L, MTHFR A1298C, MTHFR C677T and PAI-1 4G/5G genotype frequencies of patients subjected to cardiovascular disease (CVD) panel in south-east region of Turkey.
Fasting, postprandial, and post-methionine-load homocysteinaemia and methylenetetrahydrofolate reductase polymorphism in vascular disease.
Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males.
Frequency of methylenetetrahydrofolate reductase C677T polymorphism in patients with cardiovascular disease in Eastern Saudi Arabia.
Functional Polymorphism rs13306560 of the MTHFR Gene Is Associated With Essential Hypertension in a Mexican-Mestizo Population.
Genetic and Metabolite Variability in One-Carbon Metabolism Applied to an Insulin Resistance Model in Patients With Schizophrenia Receiving Atypical Antipsychotics.
Genetic factors associated with the absence of atherosclerosis in octogenarians.
Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. A case-control study.
Genetic variants predisposing to cardiovascular disease.
Head and neck cancer susceptibility: a genetic marker in the methylenetetrahydrofolate reductase gene.
Homocysteine, folate, lipid profile and MTHFR genotype and disability in children with myelomeningocele.
Implications on human fertility of the 677C-->T and 1298A-->C polymorphisms of the MTHFR gene: consequences of a possible genetic selection.
Influence of methylenetetrahydrofolate reductase genotype, exercise and other risk factors on endothelial function in healthy individuals.
Influence of MTHFR C677T gene polymorphism in the development of cardiovascular disease in Egyptian patients with rheumatoid arthritis.
Insights on the structural perturbations in human MTHFR Ala222Val mutant by protein modeling and molecular dynamics.
Interactions between the single nucleotide polymorphisms in the homocysteine pathway (MTHFR 677C>T, MTHFR 1298 A>C, and CBSins) and the efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular disease in high-risk patients of hypertension: the GenHAT study.
Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease.
Meta-analysis study to evaluate the association of MTHFR C677T polymorphism with risk of ischemic stroke.
Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants.
Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study.
Methylenetetrahydrofolate reductase (MTHFR) deficiency enhances resistance against cytomegalovirus infection.
Methylenetetrahydrofolate reductase 677 C/T genotype and cardiovascular disease mortality in postmenopausal women.
Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides.
Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene polymorphisms and associated risk of cardiovascular diseases: A study from Jammu region.
METHYLENETETRAHYDROFOLATE REDUCTASE C677T POLYMORPHISM IN PATIENTS WITH HENOCH-SCHÖNLEIN PURPURA.
Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms and susceptibility to recurrent pregnancy loss.
Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinemia, and cardiovascular diseases in chronic hemodialysis patients.
Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study.
Methylenetetrahydrofolate reductase polymorphism determines the plasma homocysteine-lowering effect of large-dose folic acid supplementation in patients with cardiovascular disease.
Methylenetetrahydrofolate reductase TT genotype as a predictor of cardiovascular risk in hypertensive adolescents.
Methylenetetrahydrofolate reductase variants associated with hypertension and cardiovascular disease interact with dietary polyunsaturated Fatty acids to modulate plasma homocysteine in puerto rican adults.
Microarray analysis of brain RNA in mice with methylenetetrahydrofolate reductase deficiency and hyperhomocysteinemia.
Molecular beacons: a new approach for semiautomated mutation analysis.
Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.
Molecular phylogenetic analysis of methylenetetrahydrofolate reductase family of proteins.
MTHFR 677C-->T mutation, folate intake, neural-tube defect, and risk of cardiovascular disease.
MTHFR A1298C polymorphism is associated with cardiovascular risk in end stage renal disease in North Indians.
MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification.
MTHFR gene polymorphism, homocysteine and cardiovascular disease.
MTHFR Gene variants C677T, A1298C and association with Down syndrome: A Case-control study from South India.
Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms.
Mutational landscape screening of methylene tetrahydrofolate reductase to predict homocystinuria associated variants: An integrative computational approach.
Nutrigenetic associations with cardiovascular disease.
Oxidative stress and platelet activation in subjects with moderate hyperhomocysteinaemia due to MTHFR 677 C ?T polymorphism.
Polymorphism in methylenetetrahydrofolate reductase gene: its impact on plasma homocysteine levels and carotid atherosclerosis in ESRD patients receiving hemodialysis.
Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men.
Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans.
Prospective study of methylenetetrahydrofolate reductase (MTHFR) variant C677T and risk of all-cause and cardiovascular disease mortality among 6000 US adults.
Recent data are not in conflict with homocysteine as a cardiovascular risk factor.
Resident Training on Methylenetetrahydrofolate Reductase: a National Survey.
Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR.
Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up.
Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogenetics.
Role of a common mutation in the homocysteine regulatory enzyme methylenetetrahydrofolate reductase in ischemic stroke.
Role of inherited thrombophilic profile on survival of patients with sepsis.
Semiautomated DNA mutation analysis using a robotic workstation and molecular beacons.
Serum homocysteine, methylenetetrahydrofolate reductase gene polymorphism and cardiovascular disease in heterozygous familial hypercholesterolemia.
Serum levels of miR-199a-5p correlates with blood pressure in premature cardiovascular disease patients homozygous for the MTHFR 677C?>?T polymorphism.
Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR.
Structural Perturbations in the Ala --> Val Polymorphism of Methylenetetrahydrofolate Reductase: How Binding of Folates May Protect against Inactivation(,).
Studying the association between methylenetetrahydrofolate reductase (MTHFR) 677 gene polymorphism, cardiovascular risk and lichen planus.
The A677V methylenetetrahydrofolate reductase gene polymorphism and carotid atherosclerosis.
The APOE E4 Allele Confers Increased Risk of Ischemic Stroke Among Greek Carriers.
The C677T methylenetetrahydrofolate reductase gene mutation does not influence cardiovascular risk in the dialysis population: results of a multicentre prospective study.
The C677T methylenetetrahydrofolate reductase polymorphism influences the homocysteine-lowering effect of hormone replacement therapy.
The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are associated with hyperhomocysteinemia and cardiovascular disease in hemodialysis patients.
The effects of genetic polymorphisms and diabetes mellitus on the development of peripheral artery disease.
The methylenetetrahydrofolate reductase C677T gene mutation is associated with hyperhomocysteinemia, cardiovascular disease and plasma B-type natriuretic peptide levels in Korea.
The methylenetetrahydrofolate reductase gene is associated with increased cardiovascular risk in Japan, but not in other populations.
The Prevalence of Methylenetetrahydrofolate Reductase 677 C-T, Factor V 1691 G-A, and Prothrombin 20210 G-A Mutations in Healthy Populations in Setif, Algeria.
Thermolabile methylenetetrahydrofolate reductase polymorphism (C677T) and total homocysteine concentration among African-American and white women.
Thermolabile methylenetetrahydrofolate reductase, homocysteine, and cardiovascular disease risk: the European Concerted Action Project.
Total homocysteine, folate, and cobalamin, and their relation to genetic polymorphisms, lifestyle and body mass index in healthy children and adolescents.
Total plasma homocysteine is associated with hypertension in Type I diabetic patients.
Unique holoenzyme dimers of the tetrameric enzyme Escherichia coli methylenetetrahydrofolate reductase: characterization of structural features associated with modulation of the enzyme's function.
[Homocysteinemia and its relationship with the methylentetrahydrofolate reductase polymorphism in various ethnic groups from western Venezuela]
[Hyperhomocysteinemia and erectile dysfunction: an update].
[Metabolic syndrome and prevention of migraine headache]
[Prevalence of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T) in the Hungarian population]
[The plasma homocysteine, folic acid and vitamin B12 levels in young people with high risk for cardiovascular disease and its relation to metylentetrahydrofolate reductase (MTHFR) gene polymorphism]
[The role of homocysteine and methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase polymorphisms in the development of cardiovascular diseases and hypertension].
Carotid Artery Diseases
An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis.
Association of methylenetetrahydrofolate reductase (MTHFR) variant C677T and risk of carotid atherosclerosis: a cross-sectional analysis of 730 Chinese Han adults in Chongqing.
Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population.
B-group vitamins, MTHFR C677T polymorphism and carotid intima-media thickness in clinically healthy subjects.
Genetic factors associated with the absence of atherosclerosis in octogenarians.
MTHFR A1298C polymorphism is associated with cardiovascular risk in end stage renal disease in North Indians.
Plasma homocyst(e)ine concentration, but not MTHFR genotype, is associated with variation in carotid plaque area.
Polymorphism in methylenetetrahydrofolate reductase gene: its impact on plasma homocysteine levels and carotid atherosclerosis in ESRD patients receiving hemodialysis.
The A677V methylenetetrahydrofolate reductase gene polymorphism and carotid atherosclerosis.
The A677V MTHFR allele is not associated with carotid atherosclerosis in octogenarians.
Thrombophilic risk factors in patients with severe carotid atherosclerosis.
Carotid Stenosis
A methylenetetrahydrofolate reductase gene polymorphism in ischaemic stroke and in carotid artery stenosis.
Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population.
Cerebrovascular events in patients with significant stenosis of the carotid artery are associated with hyperhomocysteinemia and platelet antigen-1 (Leu33Pro) polymorphism.
Polymorphism of apoprotein E (APOE), methylenetetrahydrofolate reductase (MTHFR) and paraoxonase (PON1) genes in patients with cerebrovascular disease.
Thrombophilic risk factors in patients with severe carotid atherosclerosis.
Cataract
Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis.
Associations Between Methylenetetrahydrofolate Reductase Polymorphisms, Serum Homocysteine Levels, and Incident Cortical Cataract.
Associations of Polymorphisms in MTHFR Gene with the Risk of Age-Related Cataract in Chinese Han Population: A Genotype-Phenotype Analysis.
C677T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma.
Methylenetetrahydrofolate reductase genetic polymorphisms in patients with cataract.
Celiac Disease
Celiac sprue, hyperhomocysteinemia, and MTHFR gene variants.
Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease.
Cerebral Hemorrhage
Association of CVD candidate gene polymorphisms with ischemic stroke and cerebral hemorrhage in Chinese individuals.
Evaluation of MTHFR C677T polymorphism in ischemic and hemorrhagic stroke patients. A case-control study in a Northern Indian population.
Interaction between methylenetetrahydrofolate reductase C677T gene polymorphism and sleep duration on risk of stroke pathogenesis.
Methylenetetrahydrofolate reductase gene polymorphism: relation to blood pressure and cerebrovascular disease.
Methylenetetrahydrofolate Reductase Gene Polymorphisms (C677T and A1298C) and Hemorrhagic Stroke in Moroccan Patients.
Methylenetetrahydrofolate reductase gene polymorphisms in patients with cerebral hemorrhage.
The MTHFR C677T Polymorphism and Risk of Intracerebral Hemorrhage in a Chinese Han Population.
Cerebral Infarction
An analysis of methylenetetrahydrofolate reductase and glutathione S-transferase omega-1 genes as modifiers of the cerebral response to ischemia.
Association Between MTHFR Gene Polymorphisms, Smoking, and the Incidence of Vascular Dementia.
Association of plasma homocysteine level and N5,N10-methylenetetrahydrofolate reductase gene polymorphism with cerebral infarction.
Factor V1691 G-A, prothrombin 20210 G-A, and methylenetetrahydrofolate reductase 677 C-T variants in Turkish children with cerebral infarct.
Hereditary thrombophilic factors in stroke due to cerebral infarct.
Interaction between methylenetetrahydrofolate reductase C677T gene polymorphism and sleep duration on risk of stroke pathogenesis.
Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese.
Methylenetetrahydrofolate reductase gene polymorphism: relation to blood pressure and cerebrovascular disease.
MTHFR homozygous mutation and additional risk factors for cerebral infarction in a large Italian family.
Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia.
Postoperative Symptomatic Cerebral Infarction in Pediatric Moyamoya Disease: Risk Factors and Clinical Outcome.
Prevalence of methylenetetrahydrofolate reductase C677T and its association with arterial and venous thrombosis in the Chinese population.
[Hyperhomocysteine, methylenetetrahydrofolate reductase gene, and other risk factors in ischemic stroke]
[Polimorfismos asociados a disfunción endotelial y a un estado protrombótico en jóvenes mexicanos con infarto cerebral].
Cerebral Palsy
Methylenetetrahydrofolate reductase gene polymorphisms and cerebral palsy in Chinese infants.
TNF-? and MTHFR Polymorphisms Associated with Cerebral Palsy in Chinese Infants.
Cerebral Small Vessel Diseases
Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype.
Single nucleotide polymorphism of MTHFR rs1801133 associated with elevated Hcy levels affects susceptibility to cerebral small vessel disease.
Cerebrovascular Disorders
A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease.
Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily.
Association of MTHFR C677T polymorphism and risk of cerebrovascular disease in Chinese population: an updated meta-analysis.
C677T (RS1801133 ) MTHFR gene polymorphism frequency in a colombian population.
Coexistence of Neurofibromatosis Type-1 and MTHFR C677T Gene Mutation in a Young Stroke Patient: A Case Report.
Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population.
Genetic polymorphisms and cerebrovascular disease in children with sickle cell anemia from Rio de Janeiro, Brazil.
Homozygous C677T mutation in the MTHFR gene as an independent risk factor for multiple small-artery occlusions.
Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients.
Methylenetetrahydrofolate reductase gene polymorphism is not related to the risk of ischemic cerebrovascular disease in a Brazilian population.
Methylenetetrahydrofolate reductase gene polymorphism: relation to blood pressure and cerebrovascular disease.
Methylenetetrahydrofolate reductase homozygous mutation in a young boy with cerebellar infarction.
MTHFR Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and Dementia.
Mutation in the methylenetetrahydrofolate reductase gene might be a risk factor for cerebrovascular disease in peripartum and under oral contraceptive use.
No association between MTHFR gene polymorphism and diabetic nephropathy in Japanese type II diabetic patients with proliferative diabetic retinopathy.
Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia.
Polymorphism of apoprotein E (APOE), methylenetetrahydrofolate reductase (MTHFR) and paraoxonase (PON1) genes in patients with cerebrovascular disease.
Prevalence of methylenetetrahydrofolate reductase C677T and its association with arterial and venous thrombosis in the Chinese population.
Role of a common mutation in the homocysteine regulatory enzyme methylenetetrahydrofolate reductase in ischemic stroke.
Role of Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C>T Polymorphism in Pediatric Cerebrovascular Disorders.
The effect of MTHFR c.677C>T on plasma homocysteine levels depends on health, age and smoking.
The relation between erythrocyte volume and folate levels is influenced by a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T).
[Correlation analysis between plasma homocysteine level and polymorphism of homocysteine metabolism related enzymes in ischemic cerebrovascular or cardiovascular diseases]
[Prevalence of methylenetetrahydrofolate reductase C677T mutation among patients with acute ischemic cerebrovascular disease in Aragon]
[Study on homocysteine metabolism related enzymes gene mutations in Chinese patients with ischemic cardiovascular and cerebrovascular diseases]
Cervical Intraepithelial Neoplasia
A lower degree of PBMC L1 methylation in women with lower folate status may explain the MTHFR C677T polymorphism associated higher risk of CIN in the US post folic acid fortification era.
Association between MTHFR C677T, MTHFR A1298C and MS A2756G polymorphisms and risk of cervical intraepithelial neoplasia II/III and cervical cancer: A meta-analysis.
Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12.
Lack of association between methylenetetrahydrofolate reductase C677T polymorphism, HPV infection and cervical intraepithelial neoplasia in Brazilian women.
Methylenetetrahydrofolate reductase (MTHFR) and susceptibility for (pre)neoplastic cervical disease.
Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia.
Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to cervical cancer and cervical intraepithelial neoplasia: a meta-analysis.
Methylenetetrahydrofolate reductase polymorphism C677T is not associated to the risk of cervical dysplasia.
MTHFR/p53 polymorphisms as genetic factors for cervical intraepithelial neoplasia and cervical cancer in HPV-infected Mexican women.
Polymorphisms in Genes Involved in Folate Metabolism Modify the Association of Dietary and Circulating Folate and Vitamin B-6 with Cervical Neoplasia.
Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin status.
The effect of methylenetetrahydrofolate reductase polymorphism C677T on cervical cancer in Korean women.
The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women.
The Impact of MTHFR 1298 A?>?C and 677 C?>?T Gene Polymorphisms as Susceptibility Risk Factors in Cervical Intraepithelial Neoplasia Related to HPV and Sexually Transmitted Infections.
Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are less likely to have cervical intraepithelial neoplasia (CIN) 2 or 3.
Cholangiocarcinoma
MTHFR Polymorphisms and Opisthorchis viverrini Infection: a Relationship with Increased Susceptibility to Cholangiocarcinoma in Thailand.
Polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and thymidylate synthase enhancer region (TSER) as a risk factor of cholangiocarcinoma in a Korean population.
Risk factors for cholangiocarcinoma in high-risk area of Thailand: Role of lifestyle, diet and methylenetetrahydrofolate reductase polymorphisms.
Cholelithiasis
Relationship of Cholelithiasis and Urolithiasis with Methylenetetrahydrofolate Reductase Polymorphisms.
Choline Deficiency
Disturbed One-Carbon Metabolism Causing Adverse Reproductive Outcomes in Mice Is Associated with Altered Expression of Apolipoprotein AI and Inflammatory Mediators PPAR?, Interferon-?, and Interleukin-10.
Chondrosarcoma
Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients.
Choroidal Neovascularization
Combined choroidal neovascularization and hypopituitarism in a patient with homozygous mutation in methylenetetrahydrofolate reductase gene.
Citrullinemia
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
Cleft Lip
Analysis of MTHFR Gene C.677C>T and C.1298A>C Polymorphisms in Iranian Patients with Non-Syndromic Cleft Lip and Palate.
Association between Maternal MTHFR Polymorphisms and Nonsyndromic Cleft Lip with or without Cleft Palate in Offspring, A Meta-Analysis Based on 15 Case-Control Studies.
Association between methylenetetrahydrofolate reductase polymorphisms and non-syndromic cleft lip with or without palate susceptibility: an updated systematic review and meta-analysis.
Association between MTHFR C677T and A1298C Polymorphisms and NSCL/P Risk in Asians: A Meta-Analysis.
Association Between Nonsyndromic Cleft Lip and Palate and 2 Polymorphic Loci: A Meta-Analysis.
Association of Fetal MTHFR 677C?>?T Polymorphism with Non-Syndromic Cleft Lip with or without Palate Risk: A Systematic Review and Meta-Analysis.
Association of MTHFR 1298A?>?C Polymorphism with Susceptibility to Non-Syndromic Cleft Lip with or without Palate: A Case-Control Study and Meta-Analysis.
Association of Transforming Growth Factor Alpha and Methylenetetrahydrofolate reductase gene variants with nonsyndromic cleft lip and palate in the Indian population.
Attitudes Toward Children With Clefts in Rural Muslim and Hindu Societies.
Common Mutations of the Methylenetetrahydrofolate Reductase (MTHFR) Gene in Non-Syndromic Cleft Lips and Palates Children in North-West of Iran.
Determination of Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphism in Turkish patients with nonsyndromic cleft lip and palate.
Does the interaction between maternal folate intake and the methylenetetrahydrofolate reductase polymorphisms affect the risk of cleft lip with or without cleft palate?
Family-based association study of the MTHFR polymorphism C677T in patients with nonsyndromic cleft lip and palate from central Europe.
Fetal and maternal MTHFR C677T genotype, maternal folate intake and the risk of nonsyndromic oral clefts.
Incidence Assessment of MTHFR C677T and A1298C Polymorphisms in Iranian Non-syndromic Cleft Lip and/or Palate Patients.
Infant C677T mutation in MTHFR, maternal periconceptional vitamin use, and cleft lip.
Infant C677T mutation in MTHFR, maternal periconceptional vitamin use, and risk of nonsyndromic cleft lip.
Influence of the MTHFR genotype on the rate of malformations following exposure to antiepileptic drugs in utero.
LINE-1 methylation in cleft lip tissues: Influence of infant MTHFR c.677C>T genotype.
Maternal 677CT/1298AC genotype of the MTHFR gene as a risk factor for cleft lip.
Maternal C677T MTHFR polymorphism and environmental factors are associated with cleft lip and palate in a Mexican population.
Maternal MTHFR genotype contributes to the risk of non-syndromic cleft lip and palate.
Maternal MTHFR interacts with the offspring's BCL3 genotypes, but not with TGFA, in increasing risk to nonsyndromic cleft lip with or without cleft palate.
Maternal MTHFR variant forms increase the risk in offspring of isolated nonsyndromic cleft lip with or without cleft palate.
Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Nonsyndromic Orofacial Clefts Susceptibility in a Southern Chinese Population.
MTHFR 677TT Alone and IRF6 820GG Together with MTHFR 677CT, But Not MTHFR A1298C, Are Risks for Nonsyndromic Cleft Lip with or without Cleft Palate in an Indian Population.
MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate.
MTHFR c.677C>T is a risk factor for non-syndromic cleft lip with or without cleft palate in Chile.
MTHFR C677T and A1298C polymorphisms and risk of nonsyndromic orofacial clefts in a south Indian population.
MTHFR C677T polymorphism and risk of nonsyndromic cleft lip with or without cleft palate in the Moroccan population.
MTHFR is not a risk factor in the development of isolated nonsyndromic cleft lip and palate.
MTHFR rs2274976 polymorphism is a risk marker for nonsyndromic cleft lip with or without cleft palate in the Brazilian population.
MTHFR, TGFB3, and TGFA polymorphisms and their association with the risk of non-syndromic cleft lip and cleft palate in China.
MTR, MTRR, and MTHFR Gene Polymorphisms and Susceptibility to Nonsyndromic Cleft Lip With or Without Cleft Palate.
Non-syndromic cleft palate: Association analysis on three gene polymorphisms of the folate pathway in Asian and Italian populations.
Role of the C677T polymorphism at the MTHFR gene on risk to nonsyndromic cleft lip with/without cleft palate: results from a case-control study in Brazil.
rs1801133C>T polymorphism in MTHFR is a risk factor for nonsyndromic cleft lip with or without cleft palate in the Brazilian population.
Single-nucleotide polymorphisms of methylenetetrahydrofolate reductase gene in a South Indian cohort with nonsyndromic cleft lip with or without palate.
Strong Association of C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene With Nosyndromic Cleft Lip/Palate (nsCL/P).
Study of ABCB1 multidrug resistance protein in a common orofacial malformation.
Variable contribution of the MTHFR C677T polymorphism to non-syndromic cleft lip and palate risk in China.
[Allelic polymorphism of MTHFR, MTR and MTRR genes in patients with cleft lip and/or palate and their mothers].
[Application of log-linear model in the case-parent triad study].
[Association between parental MTHFR gene polymorphism 677C/T and nonsyndromic cleft lip and palate in offspring].
[Association of methylenetetrahydrofolate reductase A1298C polymorphisms with non-syndromic cleft lip with or without cleft palate].
[Log-linear model used in the hybrid design of case-parents triad/control-mother dyad].
[MTHFR gene silencing affects mouse embryonic palatal mesenchymal cell proliferation and apoptosis]
[Relationship between genetic polymorphism of MTHFR C677T and nonsyndromic cleft lip with or without cleft palate in Shanxi Province of China].
[Relationship between genetic polymorphisms of MTHFR C677T and nonsymdromic cleft lip with or without palate.]
[Relationship between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and genetic polymorphisms of MTHFR C677T and A1298C]
Cleft Palate
5,10-Methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms in patients with nonsyndromic cleft lip and palate.
Association between Maternal MTHFR Polymorphisms and Nonsyndromic Cleft Lip with or without Cleft Palate in Offspring, A Meta-Analysis Based on 15 Case-Control Studies.
Association between methylenetetrahydrofolate reductase polymorphisms and non-syndromic cleft lip with or without palate susceptibility: an updated systematic review and meta-analysis.
Association of Fetal MTHFR 677C?>?T Polymorphism with Non-Syndromic Cleft Lip with or without Palate Risk: A Systematic Review and Meta-Analysis.
Fetal and maternal MTHFR C677T genotype, maternal folate intake and the risk of nonsyndromic oral clefts.
Incidence Assessment of MTHFR C677T and A1298C Polymorphisms in Iranian Non-syndromic Cleft Lip and/or Palate Patients.
Infant C677T mutation in MTHFR, maternal periconceptional vitamin use, and cleft lip.
Maternal MTHFR interacts with the offspring's BCL3 genotypes, but not with TGFA, in increasing risk to nonsyndromic cleft lip with or without cleft palate.
Maternal MTHFR variant forms increase the risk in offspring of isolated nonsyndromic cleft lip with or without cleft palate.
Maternal vitamin use, infant C677T mutation in MTHFR, and isolated cleft palate risk.
Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Nonsyndromic Orofacial Clefts Susceptibility in a Southern Chinese Population.
Methylenetetrahydrofolate reductase thermolabile variant and oral clefts.
MTHFR 677TT Alone and IRF6 820GG Together with MTHFR 677CT, But Not MTHFR A1298C, Are Risks for Nonsyndromic Cleft Lip with or without Cleft Palate in an Indian Population.
MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate.
MTHFR c.677C>T is a risk factor for non-syndromic cleft lip with or without cleft palate in Chile.
MTHFR C677T and A1298C polymorphisms and risk of nonsyndromic orofacial clefts in a south Indian population.
MTHFR C677T polymorphism and risk of nonsyndromic cleft lip with or without cleft palate in the Moroccan population.
MTHFR rs2274976 polymorphism is a risk marker for nonsyndromic cleft lip with or without cleft palate in the Brazilian population.
MTHFR, TGFB3, and TGFA polymorphisms and their association with the risk of non-syndromic cleft lip and cleft palate in China.
MTR, MTRR, and MTHFR Gene Polymorphisms and Susceptibility to Nonsyndromic Cleft Lip With or Without Cleft Palate.
Non-syndromic cleft palate: Association analysis on three gene polymorphisms of the folate pathway in Asian and Italian populations.
Role of the C677T polymorphism at the MTHFR gene on risk to nonsyndromic cleft lip with/without cleft palate: results from a case-control study in Brazil.
rs1801133C>T polymorphism in MTHFR is a risk factor for nonsyndromic cleft lip with or without cleft palate in the Brazilian population.
Salivary microRNAs as new molecular markers in cleft lip and palate: a new frontier in molecular medicine.
Study of ABCB1 multidrug resistance protein in a common orofacial malformation.
[Application of log-linear model in the case-parent triad study].
[Association between parental MTHFR gene polymorphism 677C/T and nonsyndromic cleft lip and palate in offspring].
[Association of methylenetetrahydrofolate reductase A1298C polymorphisms with non-syndromic cleft lip with or without cleft palate].
[Relationship between genetic polymorphism of MTHFR C677T and nonsyndromic cleft lip with or without cleft palate in Shanxi Province of China].
[Relationship between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and genetic polymorphisms of MTHFR C677T and A1298C]
Clubfoot
The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR), maternal use of folic acid supplements, and risk of isolated clubfoot: A case-parent-triad analysis.
Whole genome sequencing identifies ANXA3 and MTHFR mutations in a large family with an unknown equinus deformity associated genetic disorder.
Cluster Headache
MTHFR 677C>T Polymorphism and Cluster Headache.
coagulation factor xiia deficiency
Retinal vein occlusion in child with rare mutations in genes for thrombophilia.
Colitis
Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis, in Central China.
Colitis, Ulcerative
Combined portal, splenic and mesenteric venous thrombosis in inactive ulcerative colitis with heterozygous mutation in MTHFR gene: A rare case of thrombophilia.
Genetic polymorphism of methylenetetrahydrofolate reductase G1793A, hyperhomocysteinemia, and folate deficiency correlate with ulcerative colitis in central China.
Genotypes 677TT and 677CT+1298AC of methylenetetrahydrofolate reductase are associated with the severity of ulcerative colitis in central China.
High prevalence of combined thrombophilic abnormalities in patients with inflammatory bowel disease.
Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis, in Central China.
Methylenetetrahydrofolate reductase C677T variant in Moroccan patients with inflammatory bowel disease.
Polymorphisms of glutathione S-transferase and methylenetetrahydrofolate reductase genes in Moldavian patients with ulcerative colitis: Genotype-phenotype correlation.
The association of the MTHFR C677T polymorphism with inflammatory bowel diseases in the Israeli Jewish population: An example of genetic heterogeneity.
The methylenetetrahydrofolate reductase 1298 A>C polymorphism is associated with an increased risk of inflammatory bowel disease: evidence from a meta-analysis.
[The associations of methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms and ulcerative colitis].
[The relationship of methylenetetrahydrofolate reductase G1793A gene polymorphism, hyperhomocysteinaemia and ulcerative colitis].
Colonic Neoplasms
5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer.
5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites.
5,10-Methylenetetrahydrofolate reductase polymorphisms and colon cancer risk: a meta-analysis.
A study of the MTHFR gene polymorphism C677T in colorectal cancer.
Association between MTHFR polymorphism (C677T) with nonfamilial colorectal cancer.
Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies.
Association of methylenetetrahydrofolate reductase gene polymorphisms and sex-specific survival in patients with metastatic colon cancer.
Association of MTHFR, MTR, MTRR, RFC1, and DHFR Gene Polymorphisms with Susceptibility to Sporadic Colon Cancer.
Association of the methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia.
Associations between 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 genetic polymorphisms and environmental factors with reference to susceptibility to colorectal cancer: a case-control study in an Indian population.
Diet and cancer.
Diet and cancer: one view at the start of the millennium.
Diets, polymorphisms of methylenetetrahydrofolate reductase, and the susceptibility of colon cancer and rectal cancer.
Family history of colon cancer: what does it mean and how is it useful?
Folate status: effects on pathways of colorectal carcinogenesis.
Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet.
Genetic polymorphisms of methylenetetrahydrofolate reductase and susceptibility to colorectal cancer.
Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry.
Intraindividual somatic variations in MTHFR gene polymorphisms in relation to colon cancer.
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and risk of proximal colon cancer in north Italy.
Methylenetetrahydrofolate reductase polymorphism (677 c>t) predicts long time to progression in metastatic colon cancer treated with 5-Fluorouracil and folinic Acid.
Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea.
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.
Methylenetetrahydrofolate reductase, diet, and risk of colon cancer.
Molecular epidemiology of colon cancer.
MTHFR (C677T) polymorphisms and stage III colon cancer: response to therapy.
MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer.
MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumors.
Pharmacogenetic Predictors of Outcome in Patients with Stage II and III Colon Cancer Treated with Oxaliplatin and Fluoropyrimidine-Based Adjuvant Chemotherapy.
Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer.
Polymorphisms of MTHFR C677T and A1298C associated with survival in patients with colorectal cancer treated with 5-fluorouracil-based chemotherapy.
Recurrent thrombophlebitis in a colon cancer patient with C677T heterozygous genotype for MTHFR treated with 5-fluorouracil-based adjuvant chemotherapy.
Risk factors for colon cancer in Northeastern Thailand: interaction of MTHFR codon 677 and 1298 genotypes with environmental factors.
SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer.
The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer.
The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans.
The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: role in tumor development and significance of allelic loss in tumor progression.
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.
The MTHFR C677T and DeltaDNMT3B C-149T polymorphisms confer different risks for right- and left-sided colorectal cancer.
Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer.
Update on cobalamin, folate, and homocysteine.
Colorectal Neoplasms
5-Fluorouracil degradation rate could predict toxicity in stages II-III colorectal cancer patients undergoing adjuvant FOLFOX.
A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.
A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.
A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability.
A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk.
A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma.
A study of the MTHFR gene polymorphism C677T in colorectal cancer.
Allele and Genotype Frequencies of the Polymorphic Methylenetetrahydrofolate Reductase and Colorectal Cancer among Jordanian Population.
Association between MTHFR polymorphism (C677T) with nonfamilial colorectal cancer.
Association between MTHFR polymorphisms and overall survival of colorectal cancer patients in Northeast China.
Association between the 1793G> A MTHFR polymorphism and sporadic colorectal cancer in Iran.
Association between the MTHFR A1298C polymorphism and risk of cancer: evidence from 265 case-control studies.
Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies.
Association of C677T and A1298C MTHFR Polymorphisms and Fluoropyrimidine-induced Toxicity in Mestizo Patients With Metastatic Colorectal Cancer.
Association of Folate and Vitamins Involved in the 1-Carbon Cycle with Polymorphisms in the Methylenetetrahydrofolate Reductase Gene (MTHFR) and Global DNA Methylation in Patients with Colorectal Cancer.
Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta-analysis.
Association of methylenetetrahydrofolate reductase gene polymorphisms & colorectal cancer in India.
Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects.
Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy.
Association of single nucleotide polymorphisms in MTHFR and ABCG2 with the different efficacy of first-line chemotherapy in metastatic colorectal cancer.
Association of the 677C -->T polymorphism in the MTHFR gene with colorectal cancer in Mexican patients.
Associations between 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 genetic polymorphisms and environmental factors with reference to susceptibility to colorectal cancer: a case-control study in an Indian population.
Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo.
C677T and A1298C MTHFR gene polymorphisms and response to fluoropyrimidine-based chemotherapy in Mestizo patients with metastatic colorectal cancer.
C677T and A1298C mutations in the MTHFR gene and survival in colorectal cancer.
C677T single nucleotide polymorphism of methylenetetrahydrofolate reductase gene and colorectal cancer.
Chapter 13 methylenetetrahydrofolate reductase, common polymorphisms, and relation to disease.
Clinical utility of ABCB1 genotyping for preventing toxicity in treatment with irinotecan.
Clotting Factor Gene Polymorphisms and Colorectal Cancer Risk.
Colon cancer and genetic variation in folate metabolism: the clinical bottom line.
Colorectal cancer and the methylenetetrahydrofolate reductase 677C -> T and methionine synthase 2756A -> G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort.
Deciphering the potential value of 5-fluorouracil metabolic enzymes in predicting prognosis and treatment response of colorectal cancer patients.
Diet and prevention of colorectal cancer.
Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome: the GEOLynch cohort study.
Dietary intake of folate and alcohol, MTHFR C677T polymorphism, and colorectal cancer risk in Korea.
Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: a meta-analysis.
DPYD*2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer.
DPYD, TYMS and MTHFR Genes Polymorphism Frequencies in a Series of Turkish Colorectal Cancer Patients.
Early disease relapse in a patient with colorectal cancer who harbors genetic variants of DPYD, TYMS, MTHFR and DHFR after treatment with 5-fluorouracil-based chemotherapy.
Effect of DPYD, MTHFR, ABCB1, XRCC1, ERCC1 and GSTP1 on chemotherapy related toxicity in colorectal carcinoma.
Effects of MTHFR Genetic Polymorphisms on Toxicity and Clinical Response of Irinotecan-Based Chemotherapy in Patients with Colorectal Cancer.
Evaluation of association studies and meta-analyses of MTHFR gene polymorphisms in colorectal cancer.
Evaluation of the MTHFR C677T Polymorphism as a Risk Factor for Colorectal Cancer in Asian Populations.
Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer.
Folate Intake, MTHFR Polymorphisms, and the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis.
Folate Levels and Polymorphisms in the Genes MTHFR, MTR, and TS in Colorectal Cancer.
Folate-genetics and colorectal neoplasia: What we know and need to know next.
Folic acid and colorectal cancer prevention: molecular mechanisms and epidemiological evidence (Review).
Gene Polymorphisms MTHFRC677T and MTRA2756G as Predictive Factors in Adjuvant Chemotherapy for Stage III Colorectal Cancer.
Genetic markers for toxicity of adjuvant oxaliplatin and fluoropyrimidines in the phase III TOSCA trial in high-risk colon cancer patients.
Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer.
Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma.
Genetic polymorphisms of methylenetetrahydrofolate reductase and susceptibility to colorectal cancer.
Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry.
Genetic variants in 3'-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans.
Genetic Variants of Methyl Metabolizing Enzymes and Epigenetic Regulators: Associations with Promoter CpG Island Hypermethylation in Colorectal Cancer.
Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.
Impact of MTHFR gene C677T polymorphism on Bcl-2 gene methylation and protein expression in colorectal cancer.
Impact of SHMT1 polymorphism on the clinical outcome of patients with metastatic colorectal cancer treated with first-line FOLFIRI+bevacizumab.
Impact of the MTHFR C677T polymorphism on colorectal cancer in a population with low genetic variability.
Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome population.
Investigating the methylation status of DACT2 gene and its association with MTHFR C677T polymorphism in patients with colorectal cancer.
Involvement of genetic factors and lifestyle on the occurrence of colorectal and gastric cancer.
Letter to the editor: a meta-analyses of association between polymorphism of MTHFR A1298C and colorectal cancer risk.
Letter to the editor: a meta-analysis of MTHFR C677T polymorphism and colorectal cancer risk in East Asians.
Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer.
Localized depletion: the key to colorectal cancer risk mediated by MTHFR genotype and folate?
Loss of heterozygosity of methylenetetrahydrofolate reductase in colon carcinomas.
Low folate status, and MTHFR 677C?>?T and MTR 2756A?>?G polymorphisms associated with colorectal cancer risk in Thais: a case-control study.
Meta- and Pooled Analyses of the Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Colorectal Cancer: A HuGE-GSEC Review.
Meta-Prediction of MTHFR Gene Polymorphism Mutations and Associated Risk for Colorectal Cancer.
Methionine Synthase Reductase Gene A66G Polymorphism is Associated with Risk of Colorectal Cancer.
Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer.
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients.
Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: a population-based case-control study.
Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer.
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study.
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and fluorouracil-based treatment in Taiwan colorectal cancer.
Methylenetetrahydrofolate reductase C677T gene polymorphism and colorectal cancer risk: A case-control study.
Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status.
Methylenetetrahydrofolate reductase C677T is not associated with expression of pyrimidine metabolic enzyme genes in colorectal cancer.
Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis.
Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro.
Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population.
Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer.
Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice.
Methylenetetrahydrofolate reductase gene germ-line C677T and A1298C SNPs are associated with colorectal cancer risk in the Turkish population.
Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients.
Methylenetetrahydrofolate reductase gene polymorphisms and the risk of colorectal carcinoma in a sample of Egyptian individuals.
Methylenetetrahydrofolate reductase gene polymorphisms: genomic predictors of clinical response to fluoropyrimidine-based chemotherapy?
Methylenetetrahydrofolate reductase genotypes and haplotypes associated with susceptibility to colorectal cancer in an eastern Chinese Han population.
Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas.
Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy.
Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea.
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.
Methylenetetrahydrofolate reductase polymorphisms and colorectal cancer prognosis: A meta-analysis.
Methylenetetrahydrofolate reductase polymorphisms and risk of sporadic and hereditary colorectal cancer with or without microsatellite instability.
MTHFR 677 C>T and 1298 A>C polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer.
MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic.
MTHFR C677T and A1298C variant genotypes and the risk of microsatellite instability among Iranian colorectal cancer patients.
MTHFR C677T and colorectal cancer risk: A meta-analysis of 25 populations.
MTHFR C677T has differential influence on risk of MSI and MSS colorectal cancer.
MTHFR C677T polymorphism and anatomopathological characteristics with prognostic significance in sporadic colorectal cancer.
MTHFR C677T polymorphism and colorectal cancer risk in Asians, a meta-analysis of 21 studies.
MTHFR C677T polymorphism contributes to colorectal cancer susceptibility: evidence from 61 case-control studies.
MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: A meta-analysis.
MTHFR gene polymorphisms and response to chemotherapy in colorectal cancer: a meta-analysis.
MTHFR genetic testing: Controversy and clinical implications.
MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial.
MTHFR Glu429Ala and ERCC5 His46His polymorphisms are associated with prognosis in colorectal cancer patients: analysis of two independent cohorts from Newfoundland.
MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene-environment interactions in colorectal tumorigenesis.
MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer.
MTHFR polymorphisms and capecitabine-induced toxicity in patients with metastatic colorectal cancer.
MTHFR polymorphisms as prognostic factors in sporadic colorectal cancer.
MTHFR rs1801133 polymorphism and susceptibility to colorectal cancer in Iranian population: evidence of a case-control study and meta-analysis.
MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer.
MTRR rs1801394 and its interaction with MTHFR rs1801133 in colorectal cancer: a case-control study and meta-analysis.
Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer.
One-carbon metabolism and CpG island methylator phenotype status in incident colorectal cancer: a nested case-referent study.
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case-control studies.
Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort study.
Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.
Polymorphisms in genes involved in folate metabolism and plasma DNA methylation in colorectal cancer patients.
Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake.
Polymorphisms of folate metabolism-related genes and survival of patients with colorectal cancer in the Korean population.
Polymorphisms of MTHFR C677T and A1298C associated with survival in patients with colorectal cancer treated with 5-fluorouracil-based chemotherapy.
Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer.
Predictors of patient uptake of colorectal cancer gene environment risk assessment.
Promoter Hypermethylation of Wnt/?-catenin Signaling Pathway Inhibitor WIF-1 Gene and its Association with MTHFR C677T Polymorphism in Patients with Colorectal Cancer.
Quantitative assessment of the association between MTHFR C677T polymorphism and colorectal cancer risk in East Asians.
Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency.
Relationship between metabolic enzyme polymorphism and colorectal cancer.
Relationship between Metabolic Syndrome and MTHFR Polymorphism in Colorectal Cancer.
Relationship of the methylenetetrahydrofolate reductase C677T polymorphism with microsatellite instability and promoter hypermethylation in sporadic colorectal cancer.
Relevance of methylenetetrahydrofolate reductase gene variants C677T and A1298C with response to fluoropyrimidine-based chemotherapy in colorectal cancer: a systematic review and meta-analysis.
Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population.
Role of depth of response and MTHFR genotype as predictors of fluorouracil rechallenge therapy for refractory metastatic colorectal cancer.
Role of MTHFR polymorphisms and folate levels in different phenotypes of sporadic colorectal cancers.
The 677C > T mutation in 5,10-methylenetetrahydrofolate reductase and colorectal cancer risk.
The 677C>T (rs1801133) Polymorphism in the MTHFR Gene Contributes to Colorectal Cancer Risk: A Meta-Analysis Based on 71 Research Studies.
The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer.
The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase.
The Impact of Thymidylate Synthase and Methylenetetrahydrofolate Reductase Genotypes on Sensitivity to 5-Fluorouracil Treatment in Colorectal Cancer Cells.
The interactive effect of methyl-group diet and polymorphism of methylenetetrahydrofolate reductase on the risk of colorectal cancer.
The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: role in tumor development and significance of allelic loss in tumor progression.
The methylenetetrahydrofolate reductase 677C-->T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism.
The MTHFR C677T and DeltaDNMT3B C-149T polymorphisms confer different risks for right- and left-sided colorectal cancer.
The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study.
The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer.
The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study.
The reduced folate carrier (RFC1) 80G>A and folate hydrolase 1 (FOLH1) 1561C>T polymorphisms and the risk of colorectal cancer: a nested case-referent study.
The Role of
Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients.
Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma.
Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy.
Variant alleles in factor V, prothrombin, plasminogen activator inhibitor-1, methylenetetrahydrofolate reductase and risk of thromboembolism in metastatic colorectal cancer patients treated with first-line chemotherapy plus bevacizumab.
Variants in CDA and ABCB1 are predictors of capecitabine-related adverse reactions in colorectal cancer.
Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients.
Which gene is a dominant predictor of response during FOLFOX chemotherapy for the treatment of metastatic colorectal cancer, the MTHFR or XRCC1 gene?
[677T mutation of the MTHFR gene in adenomas and colorectal cancer in a population sample from the Northeastern Mexico. Preliminary results]
[A case-control study on the polymorphisms of methylenetetrahydrofolate reductases, drinking interaction and susceptibility in colorectal cancer]
[Activity of the National Oncology R&D Consortium in 2004]
[Association between genetic variations in methylenetetrahydrofolate reductase and risk of colorectal cancer in a Chinese population]
[Association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of sporadic colorectal cancer].
[Correlation between C677T and A1298C mutations of the MTHFR gene and therapeutic prognostic elements in colorectal cancer]
[Methylenetetrahydrofolate reductase polymorphisms and colorectal cancer risk: a human genomic epidemiologic review.]
[The clinical importance of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the 5-fluoropyrimidine-based therapy of metastatic colorectal tumours]
Colorectal Neoplasms, Hereditary Nonpolyposis
Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome: the GEOLynch cohort study.
Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome population.
MTHFR 677 C>T and 1298 A>C polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer.
Coma
Psychosis, paraplegia and coma revealing methylenetetrahydrofolate reductase deficiency in a 56-year-old woman.
Communicable Diseases
Methylenetetrahydrofolate reductase (MTHFR) deficiency enhances resistance against cytomegalovirus infection.
Confusion
Epigenetics in Clinical Practice: Characterizing Patient and Provider Experiences with MTHFR Polymorphisms and Methylfolate.
Congenital Abnormalities
Application of kinetic polymerase chain reaction and molecular beacon assays to pooled analyses and high-throughput genotyping for candidate genes.
Association between MTHFR Gene Polymorphisms and the Risk of Autism Spectrum Disorders: A Meta-Analysis.
Association of folate metabolism genes MTHFR and MTRR with multiple complex congenital malformation risk in Chinese population of Shanxi.
Associations between maternal methylenetetrahydrofolate reductase polymorphisms and adverse outcomes of pregnancy: the Hordaland Homocysteine Study.
Choline metabolites: gene by diet interactions.
Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer.
Evaluation of High Resolution Melting for MTHFR C677T Genotyping in Congenital Heart Disease.
Geographical and ethnic distribution of MTHFR gene polymorphisms and their associations with diseases among Chinese population.
Increased Resistance to Malaria in Mice with Methylenetetrahydrofolate Reductase (Mthfr) Deficiency Suggests a Mechanism for Selection of the MTHFR 677C>T (c.665C>T) Variant.
Methylenetetrahydrofolate Reductase A1298C Polymorphism and Breast Cancer Risk: A Meta-analysis of 33 Studies.
Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice.
Methylenetetrahydrofolate reductase gene A1298C polymorphism and susceptibility to recurrent pregnancy loss: a meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphisms in 13 Chinese ethnic populations.
Neonatal sinovenous thrombosis associated with homozygous thermolabile methylenetetrahydrofolate reductase in both mother and infant.
Nucleofection is highly efficient for transfecting genes into murine embryonic palatal mesenchymal cells in primary culture.
Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects.
Prevalence of the methylenetetrahydrofolate reductase 677C>T polymorphism in the pregnant women of Yunnan Province, China.
Role of MTHFR C677T gene polymorphism in the susceptibility of schizophrenia: An updated meta-analysis.
Sex-dependent behavioral effects of Mthfr deficiency and neonatal GABA potentiation in mice.
Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate.
The association between maternal methylenetetrahydrofolate reductase C677T and A1298C polymorphism and birth defects and adverse pregnancy outcomes.
The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction.
The role of FV 1691G>A, FII 20210G>A mutations and MTHFR 677C>T; 1298A>C and 103G>T FXIII gene polymorphisms in pathogenesis of intraventricular hemorrhage in infants born before 32 weeks of gestation.
Update on cobalamin, folate, and homocysteine.
[Association of folate metabolism genes MTRR and MTHFR with complex congenital abnormalities among Chinese population in Shanxi Province, China].
[Meta-analysis on relationship between the Chinese maternal MTHFR gene polymorphism(C677T) and neural tube defects in offspring].
[Supplementation with folic acid before and during pregnancy]
Congenital Hypothyroidism
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
Congenital Microtia
[Polymorphism analysis of MTHFR?BMPR1B and TYMS in microtia].
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Venous thrombosis and procoagulant factors in high-risk neuroblastoma.
Coronary Artery Disease
677TT polymorphism of methylenetetrahydrofolate reductase in combination with low serum vitamin B(12) is associated with coronary in-stent restenosis.
A Case-Control Study of the Association of the Polymorphisms of MTHFR and APOE with Risk Factors and the Severity of Coronary Artery Disease.
A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction.
A low prevalence of the C677T mutation in the methylenetetrahydrofolate reductase gene in Asian Indians.
A mutation in the methylenetetrahydrofolate reductase gene is not associated with increased risk for coronary artery disease or myocardial infarction.
A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocysteine/folate metabolism.
Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and the risk of coronary artery disease.
Age and hypertension related changes in genotypes of MTHFR 677C>T, 1298A>C and PON1 -108C>T SNPs in men with coronary artery disease (CAD).
An MTHFR variant, plasma homocysteine levels and late-onset coronary artery disease in subjects from southern Iran.
Association Between MTHFR Gene Common Variants, Serum Homocysteine, and Risk of Early-Onset Coronary Artery Disease: A Case-Control Study.
Association of coronary artery disease with polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase gene.
Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD).
Association of genetic variants in Methylenetetrahydrofolate Reductase and Paraoxonase-1 genes with homocysteine, folate and vitamin B12 in coronary artery disease.
Association of homocysteine and methylene tetrahydrofolate reductase (MTHFR C677T) gene polymorphism with coronary artery disease (CAD) in the population of North India.
Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population.
Association of the C677T MTHFR polymorphism with homocysteine, ox-LDL levels, and thiolactonase activities in the severity of coronary syndrome.
Associations of the MTHFR rs1801133 polymorphism with coronary artery disease and lipid levels: a systematic review and updated meta-analysis.
C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease.
C677T mutation of the methylenetetrahydrofolate reductase gene among the Korean infants in Seoul city.
C677T polymorphism of the 5,10 MTHFR gene in young Mexican subjects with ST-elevation myocardial infarction.
Cardiology patient pages. Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease.
Carrier-state of D allele in ACE gene insertion/deletion polymorphism is associated with coronary artery disease, in contrast to the C677-->T transition in the MTHFR gene.
Carrier-state of two or three polymorphic variants of MTHFR, IL-6 and ICAM1 genes increases the risk of coronary artery disease.
Circulating homocysteine levels in patients with type 2 diabetes mellitus.
Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease.
Cystathionine beta-synthase 844Ins68 polymorphism is not associated with the levels of homocysteine and cysteine in an Indian population.
Dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization.
Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia.
Factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase polymorphism C677T are not associated with coronary artery disease and type 2 diabetes mellitus in western Iran.
Factor V G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T gene polymorphism in angiographically documented coronary artery disease.
Family history, plasma homocysteine, and age at onset of symptoms of myocardial ischemia in patients with different methylenetetrahydrofolate reductase genotypes.
Frequency of MTHFR G1793A polymorphism in individuals with early coronary artery disease: cross-sectional study.
Gene polymorphisms of homocysteine metabolism-related enzymes in Chinese patients with occlusive coronary artery or cerebral vascular diseases.
Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population.
Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction.
Genetic interactions between MTHFR (C677T), methionine synthase (A2756G, C2758G) variants with vitamin B12 and folic acid determine susceptibility to premature coronary artery disease in Indian population.
Genetic Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) and Coronary Artery Disease.
Genetic polymorphism of MTHFR C677T and premature coronary artery disease susceptibility: A meta-analysis.
Genetic variation of the methylenetetrahydrofolate reductase and cystathionine beta-synthase genes in Korean patients with coronary artery disease and a new polymorphism in intron 7.
High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 677C-->T genotypes.
Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Tunisian patients with severe coronary artery disease.
Homocysteine and methylenetetrahydrofolate reductase in subjects undergoing coronary angiography.
Homocysteine and MTHFR and VEGF gene polymorphisms: impact on coronary artery disease.
Homocysteine and the MTHFR 677C-->T allele in premature coronary artery disease. Case control and family studies.
Homocysteine status and polymorphisms of methylenetetrahydrofolate reductase are not associated with restenosis after stenting in coronary arteries.
Homocysteine, lipoprotein(a), and restenosis after percutaneous transluminal coronary angioplasty: a prospective study.
Hyperhomocysteinaemia, methylenetetrahydrofolate reductase polymorphism and risk of coronary artery disease.
Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in a patient with coronary artery disease and repetitive miscarriages.
Identification of six methylenetetrahydrofolate reductase (MTHFR) genotypes resulting from common polymorphisms: impact on plasma homocysteine levels and development of coronary artery disease.
Identifying genetic susceptibilities to diabetes-related complications among individuals at low risk of complications: An application of tree-structured survival analysis.
Impact of ethnicity and MTHFR genotype on age at onset of coronary artery disease in women in Israel.
Impact of Genetic Defects on Coronary Atherosclerosis among Turkish Cypriots.
Interaction among 5,10 methylenetetrahydrofolate reductase, plasminogen activator inhibitor and endothelial nitric oxide synthase gene polymorphisms predicts the severity of coronary artery disease in Turkish patients.
Lack of association of methylenetetrahydrofolate reductase 677C>T mutation with coronary artery disease in a Pakistani population.
Low plasma folate in combination with the 677 C-->T methylenetetrahydrofolate reductase polymorphism is associated with increased risk of coronary artery disease in Koreans.
Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid.
Methylenetetrahydrofolate reductase (MTHFR) mutation, homocyst(e)ine, and coronary artery disease.
Methylenetetrahydrofolate reductase C667T polymorphism is associated with increased risk of coronary artery disease in a Chinese population.
Methylenetetrahydrofolate reductase C677T gene polymorphism and coronary artery disease in a Chinese Han population: a meta-analysis.
Methylenetetrahydrofolate reductase C677T polymorphism is associated with increased risk of coronary artery disease in young South African Indians.
Methylenetetrahydrofolate reductase gene and coronary artery disease.
Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery disease.
Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease.
Methylenetetrahydrofolate reductase gene polymorphism and coronary artery disease in Taiwan Chinese.
Methylenetetrahydrofolate reductase gene polymorphism and its association with coronary artery disease.
Methylenetetrahydrofolate reductase gene polymorphism: relation to blood pressure and cerebrovascular disease.
Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: The A1298C polymorphism does matter. Inferences from a case study (Madeira, Portugal).
Methylenetetrahydrofolate reductase genotypes and early-onset coronary artery disease.
Methylenetetrahydrofolate reductase mutation (677C-->T) negatively influences plasma homocysteine response to marginal folate intake in elderly women.
Methylenetetrahydrofolate reductase mutation and coronary artery disease.
Methylenetetrahydrofolate reductase polymorphism (C-677T) and coronary artery disease.
Methylenetetrahydrofolate Reductase Polymorphism and Premature Coronary Artery Disease.
Methylenetetrahydrofolate reductase polymorphism in healthy volunteers and its correlation with homocysteine levels in patients with thrombosis.
Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease, and essential hypertension in the Czech population.
Methylenetetrahydrofolate reductase TT genotype as a predictor of cardiovascular risk in hypertensive adolescents.
MTHFR 677 C-->T mutation: a predictor of early-onset coronary artery disease risk.
Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease.
Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia.
Mutation C677T of methylenetetrahydrofolate reductase gene is not associated with coronary artery disease, but possibly with albuminuria, in type 2 diabetic patients.
No association between MTHFR gene polymorphism and diabetic nephropathy in Japanese type II diabetic patients with proliferative diabetic retinopathy.
OLR1 , PON1 and MTHFR Gene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population.
Plasma homocysteine levels & 677C-->T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity.
Polymorphism (C677T) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene: A preliminary study on north Indian men.
Polymorphisms of methylenetetrahydrofolate reductase gene as the genetic predispositions of coronary artery diseases in eastern India.
Prevalence and role of methylenetetrahydrofolate reductase 677 C-->T and 1298 A-->C polymorphisms in coronary artery disease in Arabs.
Prevalence of methylenetetrahydrofolate reductase C677T and its association with arterial and venous thrombosis in the Chinese population.
Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C).
Relation between plasma homocysteine, gene polymorphisms of homocysteine metabolism-related enzymes, and angiographically proven coronary artery disease.
Relation of a common methylenetetrahydrofolate reductase mutation and plasma homocysteine with intimal hyperplasia after coronary stenting.
Relation of a common mutation in methylenetetrahydrofolate reductase to plasma homocysteine and early onset coronary artery disease.
Role of homocysteine & MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians.
Role of Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C>T Polymorphism in Pediatric Cerebrovascular Disorders.
Serum homocysteine concentrations, gemfibrozil treatment, and progression of coronary atherosclerosis.
Serum homocysteine, methylenetetrahydrofolate reductase gene polymorphism and cardiovascular disease in heterozygous familial hypercholesterolemia.
Sex-specific effect of the thermolabile C677T mutation in the methylenetetrahydrofolate reductase gene on angiographically assessed coronary artery disease in Brazilians.
Synergistic association of DNA repair relevant gene polymorphisms with the risk of coronary artery disease in northeastern Han Chinese.
The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels.
The C677T mutation in methylenetetrahydrofolate reductase gene, plasma homocysteine concentration and the risk of coronary artery disease.
The C677T mutation in the methylenetetrahydrofolate reductase gene among the Indonesian Javanese population.
The C677T mutation of the methylenetetrahydrofolate reductase gene is not associated with the risk of coronary artery disease or venous thrombosis among Chinese in Taiwan.
The communal relation of MTHFR, MTR, ACE gene polymorphisms and hyperhomocysteinemia as conceivable risk of coronary artery disease.
The effect of a common methylenetetrahydrofolate reductase mutation on levels of homocysteine, folate, vitamin B12 and on the risk of premature atherosclerosis.
The effect of polymorphisms of MTHER gene and vitamin B on hyperhomocysteinemia.
The estimation of gametic disequilibrium between DNA markers in candidate genes for coronary artery disease (CAD) and the associations of gene complexes with risk factors for CAD.
The graded effect of hyperhomocysteinemia on the severity and extent of coronary atherosclerosis.
The high prevalence of thermolabile 5-10 methylenetetrahydrofolate reductase (MTHFR) in Italians is not associated to an increased risk for coronary artery disease (CAD).
The interaction between MTHFR 677 C-->T genotype and folate status is a determinant of coronary atherosclerosis risk.
The methylenetetrahydrofolate reductase gene polymorphism in Koreans with coronary artery disease.
The relationship of the methylenetetrahydrofolate reductase C677T gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy.
The role of genetics in coronary artery bypass surgery patients under 30 years of age.
The rs1801133 polymorphism of methylenetetrahydrofolate reductase gene- the association with 5-year survival in patients with ST-elevation myocardial infarction.
The TT genotype of the methylenetetrahydrofolate reductase C677T gene polymorphism is associated with the extent of coronary atherosclerosis in patients at high risk for coronary artery disease.
The TT genotype of the MTHFR 677C > T polymorphism increases susceptibility to premature coronary artery disease in interaction with some of the traditional risk factors.
Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease.
Thermolabile Methylenetetrahydrofolate Reductase C677T Polymorphism and Homocysteine Are Risk Factors for Coronary Artery Disease in Moroccan Population.
Thermolabile methylenetetrahydrofolate reductase in coronary artery disease.
Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease.
Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.
[Analysis of gene complexes predisposing to coronary atherosclerosis]
[Analysis of the MTHFR gene linkage disequilibrium structure and association of polymorphic gene variants with coronary atherosclerosis].
[Evaluation of MTHFR C677T gene polymorphism and homocysteine level in coronary atherosclerotic disease]
[Familial predisposition to ischemic cardiopathy: role of homocysteine and genetic polymorphism of methylenetetrahydrofolate reductase]
[Gene Polymorphism of 5, 10-methylenetetrahydrofolate reductase as a coronary risk factor]
[MTHFR genetic variability on coronary artery disease development]
[Relationship between polymorphism C677T of the methylene tetrahydrofolate reductase gene with clinical symptoms of coronary atherosclerosis]
[Smoking enhances the decrease of adiponectin level in patients with coronary artery disease, carriers of MTHFR 677T and PON1 55M alleles].
Coronary Disease
5,10-methylenetetrahydrofolate reductase C677T gene polymorphism and peripheral arterial disease: A meta-analysis.
A common mutation in the methylenetetrahydrofolate reductase gene and risk of coronary heart disease: results among U.S. men.
ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing.
An integrated approach to the meta-analysis of genetic association studies using Mendelian randomization.
Apolipoprotein E and methylenetetrahydrofolate reductase genetic polymorphisms in relation to other risk factors for cardiovascular disease in UK Caucasians and Black South Africans.
Detection of C677T mutation of MTHFR in subject with coronary heart disease by hairpin probe with enzymatic color on microarray.
Distribution in healthy and coronary populations of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation.
Genetic risk factors in acute coronary disease.
Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias.
Homocysteine and methylenetetrahydrofolate reductase genotype: association with risk of coronary heart disease and relation to inflammatory, hemostatic, and lipid parameters.
Hyperhomocyst(e)inemia, MTHFR 677C-->T polymorphism and folate status in acute coronary disease.
Hyperhomocysteinemia, MTHFR C677T genotype and low folate levels: a risk combination for acute coronary disease in a Portuguese population.
Improved real-time multiplex polymerase chain reaction detection of methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C polymorphisms using nearest neighbor model-based probe design.
Interaction between Mediterranean diet and methylenetetrahydrofolate reductase C677T mutation on oxidized low density lipoprotein concentrations: The ATTICA study.
Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes.
Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?
Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study.
Methylenetetrahydrofolate reductase 677 C-->T mutation and coronary heart disease risk in UK Indian Asians.
Methylenetetrahydrofolate reductase and apolipoprotein E polymorphisms are independent risk factors for coronary heart disease in Japanese: a case-control study.
Methylenetetrahydrofolate reductase gene mutation and hyperhomocysteinemia as a risk factor for coronary heart disease in the Indian population.
Methylenetetrahydrofolate Reductase Gene Polymorphism C677T is Associated with Increased Risk of Coronary Heart Disease in Chinese Type 2 Diabetic Patients.
Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes.
Methylenetetrahydrofolate reductase polymorphism associated with susceptibility to coronary heart disease in Chinese type 2 diabetic patients.
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.
MTHFR C677T Polymorphism and Serum Homocysteine Level as Risk Factors of Coronary Heart Disease in Patients with Androgenetic Alopecia: A Case Control Study.
Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia.
Relationship between two sequence variations in the gene for peroxisome proliferator-activated receptor-gamma and plasma homocysteine concentration. Health in men study.
Review: MTHFR TT genotype increases risk for coronary heart disease.
The APOE E4 Allele Confers Increased Risk of Ischemic Stroke Among Greek Carriers.
The association between plasma homocysteine and coronary heart disease is modified by the MTHFR 677C>T polymorphism.
The association of MTHFR C677T gene variants and lipid profiles or body mass index in patients with diabetic and nondiabetic coronary heart disease.
The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes.
The human MTHFR rs4846049 polymorphism increases coronary heart disease risk through modifying miRNA binding.
The methylenetetrahydrofolate reductase gene polymorphism (C677T) is associated with increased cardiovascular mortality in Hungary.
[Association of methylenetetrahydrofolate reductase gene polymorphism with the development of myocardial infarction in patients with type 2 diabetes].
[C677T genetic polymorphism of methylenetetrahydrofolate reductase in premature coronary heart disease]
[Genetic polymorphisms of homocysteine metabolism related enzymes in patients with coronary heart disease]
[Increase of homocysteine in cardiovascular diseases in Hungary]
[Introduction on "case-sibling control design"]
[Levels of homocysteine and polymorphisms of homocysteine metabolism-related enzymes in patients with type 2 diabetes mellitus and coronary heart disease]
[Relationship between methylenetetrahydrofolate reductase gene polymorphism and coronary heart disease]
[Study on the relationship between methylenetetrahydrofolate reductase gene C677T mutation and coronary heart disease]
Coronary Stenosis
Prevalence of methylenetetrahydrofolate reductase C677T and its association with arterial and venous thrombosis in the Chinese population.
Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease.
[Effect of polymorphisms on key enzymes in homocysteine metabolism, on plasma homocysteine level and on coronary artery-disease risk in a Tunisian population]
[Increase of homocysteine in cardiovascular diseases in Hungary]
Coronary Thrombosis
Myocardial Infarction in a Newborn Heterozygous for the MTHFR C677T Mutation.
COVID-19
COVID-19 spreading across world correlates with C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene prevalence.
Craniosynostoses
Methylenetetrahydrofolate reductase C677T variant in Indian children with craniosynostosis: Its role in the pathogenesis, risk of craniosynostosis.
Crohn Disease
Anterior ischemic optic neuropathy in a patient with Crohn's disease and aberrant MTHFR and GPIIIa gene variants.
High prevalence of combined thrombophilic abnormalities in patients with inflammatory bowel disease.
Methylenetetrahydrofolate reductase C677T variant in Moroccan patients with inflammatory bowel disease.
The association of the MTHFR C677T polymorphism with inflammatory bowel diseases in the Israeli Jewish population: An example of genetic heterogeneity.
cystathionine beta-synthase deficiency
Homozygous cystathionine beta-synthase deficiency, combined with factor V Leiden or thermolabile methylenetetrahydrofolate reductase in the risk of venous thrombosis.
Impact of new mutations in the methylenetetrahydrofolate reductase gene assessed on biochemical phenotypes: a familial study.
Molecular and clinical characterisation of homocystinuria in two Austrian families with cystathionine beta-synthase deficiency.
Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines.
Newborn screening for homocystinurias: recent recommendations versus current practice.
Newborn screening for homocystinurias: Recent recommendations versus current practice.
Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia.
The Effect of in Vitro Homocystinuria on the Suckling Rat Hippocampal Acetylcholinesterase.
The effect of in vitro homocystinuria on the suckling rat hippocampal acetylcholinesterase.
Treatment of inherited homocystinurias.
[Cystathionine betasynthase and MTHFR deficiencies in adults]
cystathionine gamma-synthase deficiency
Genetic and nongenetic factors for moderate hyperhomocyst(e)inemia.
Treatment of hyperhomocyst(e)inemia: physiological basis.
[Hyperhomocysteinemia--a risk factor for development of occlusive vascular diseases]
Cystic Fibrosis
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
Cysts
MTHFR homozygous mutation and additional risk factors for cerebral infarction in a large Italian family.
Cytomegalovirus Infections
Methylenetetrahydrofolate reductase (MTHFR) deficiency enhances resistance against cytomegalovirus infection.
Dementia
ACE, MTHFR, factor V Leiden, and APOE polymorphisms in patients with vascular and Alzheimer's dementia.
Analysis of alpha-1 antichymotrypsin, presenilin-1, angiotensin-converting enzyme, and methylenetetrahydrofolate reductase loci as candidates for dementia.
Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease.
Association of MTHFR C677T polymorphism with loneliness but not depression in cognitively normal elderly males.
Genetic Associations of Autopsy-Confirmed Vascular Dementia Subtypes.
Genetic polymorphisms in older subjects with vascular or Alzheimer's dementia.
Heterozygote advantage of the MTHFR C677T polymorphism on specific cognitive performance in elderly Chinese males without dementia.
Increased MTHFR promoter methylation in mothers of Down syndrome individuals.
Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland.
Molecular genetics of Alzheimer's disease and aging.
MTHFR and ACE gene polymorphisms and risk of vascular and degenerative dementias in the elderly.
MTHFR Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and Dementia.
Plasma homocysteine and MTHFRC677T polymorphism as risk factors for incident dementia.
Plasma total homocysteine levels and the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene: a study in an Italian population with dementia.
The active site of oxidative phosphorylation and the origin of hyperhomocysteinemia in aging and dementia.
The Different Relationship between Homocysteine and Uric Acid Levels with Respect to the MTHFR C677T Polymorphism According to Gender in Patients with Cognitive Impairment.
The sex-specific effect of the apolipoprotein E allele and methylenetetrahydrofolate reductase gene polymorphism on the biochemical, anatomical, and cognitive profiles of patients clinically diagnosed with probable Alzheimer's disease.
Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85.
[Stroke and the genetics of hyperhomocysteinemia]
Dementia, Vascular
Apolipoprotein E, methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia--an epidemiological study using the polymerase chain reaction (PCR) method.
Association Between MTHFR Gene Polymorphisms, Smoking, and the Incidence of Vascular Dementia.
Common polymorphisms in methylenetetrahydrofolate reductase (MTHFR): relationships with plasma homocysteine concentrations and cognitive status in elderly northern italian subjects.
Genetic polymorphisms in older subjects with vascular or Alzheimer's dementia.
Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland.
MTHFR (677 and 1298) and IL-6-174 G/C genes in pathogenesis of Alzheimer's and vascular dementia and their epistatic interaction.
Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia.
The C677T methylenetetrahydrofolate reductase mutation is not associated with Alzheimer's disease.
The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene and vascular dementia.
The MTHFR C677T polymorphism contributes to an increased risk for vascular dementia: A meta-analysis.
Demyelinating Diseases
Hydrocephalus internus in two patients with 5,10-methylenetetrahydrofolate reductase deficiency.
Depression, Postpartum
Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype.
Dermatitis, Atopic
High Circulating Folate and Vitamin B-12 Concentrations in Women During Pregnancy Are Associated with Increased Prevalence of Atopic Dermatitis in Their Offspring.
Diabetes Complications
Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility.
Is the C677T polymorphism in methylenetetrahydrofolate reductase gene or plasma homocysteine a risk factor for diabetic peripheral neuropathy in Chinese individuals?
Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes.
Thermolabile methylenetetrahydrofolate reductase enzyme genotype is frequent in type 2 diabetic patients with normal fasting homocysteine levels.
Diabetes Mellitus
A study on the correlation between MTHFR promoter methylation and diabetic nephropathy.
Assessment of genetic risk for myocardial infarction.
Association between folate metabolism-related polymorphisms and colorectal cancer risk.
Association Between Homocysteine Level and Methylenetetrahydrofolate Reductase Gene Polymorphisms in Type 2 Diabetes Accompanied by Dyslipidemia.
Association between MTHFR C677T polymorphism and diabetic nephropathy or diabetes mellitus risk: need for clarification of data in a recent meta-analysis.
Association of ACE and MTHFR genetic polymorphisms with type 2 diabetes mellitus: Susceptibility and complications.
Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary risk factors.
Association of genetic polymorphism of PPAR?-2, ACE, MTHFR, FABP-2 and FTO genes in risk prediction of type 2 diabetes mellitus.
Association of MTHFR and PPAR?2 gene polymorphisms in relation to type 2 diabetes mellitus cases among north Indian population.
Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility.
Association of plasma homocysteine with serum interleukin-6 and C-peptide levels in patients with type 2 diabetes.
Association of polymorphism of methylene-tetrahydro-folate-reductase with urinary albumin excretion rate in type 1 diabetes mellitus but not with preeclampsia, retinopathy, and preterm delivery.
Association of tagging SNPs in the MTHFR gene with risk of type 2 diabetes mellitus and serum homocysteine levels in a Chinese population.
Association of the C677T Polymorphism in the Human Methylenetetrahydrofolate Reductase (MTHFR) Gene with the Genetic Predisposition for Type 2 Diabetes Mellitus in a Moroccan Population.
Blood S-adenosylmethionine concentrations and lymphocyte methylenetetrahydrofolate reductase activity in diabetes mellitus and diabetic nephropathy.
Does the MTHFR C677T gene polymorphism indicate cardiovascular disease risk in type 2 diabetes mellitus patients?
Factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase polymorphism C677T are not associated with coronary artery disease and type 2 diabetes mellitus in western Iran.
Genetic polymorphism of 5,10-methylenetetrahydrofolate increases risk of myocardial infarction and is correlated to elevated levels of homocysteine in the Japanese general population.
Genetic Predisposition for Development of Nephropathy in Type 2 Diabetes Mellitus.
Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis.
Hyperhomocysteinemia and elevated ox-LDL in Tunisian type 2 diabetic patients: role of genetic and dietary factors.
Impaired Placentation and Early Pregnancy Loss in Patients with MTHFR Polymorphisms and Type-1 Diabetes Mellitus.
Interaction of eNOS polymorphism with MTHFR variants increase the risk of diabetic nephropathy and its progression in type 2 diabetes mellitus patients.
Interaction of MTHFR C677T polymorphism with smoking in susceptibility to diabetic nephropathy in Chinese men with type 2 diabetes.
Is the C677T Polymorphism in Methylenetetrahydrofolate Reductase Gene a Risk Factor for Diabetic Nephropathy or Diabetes Mellitus in a Chinese Population?
Methylene tetrahydrofolate reductase C677T mutation and left ventricular hypertrophy in Turkish patients with type II diabetes mellitus.
Methylenetetrahydrofolate Reductase (MTHFR) (C677T and A1298C) Polymorphisms and Vascular Complications in Patients with Type 2 Diabetes.
Methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and diabetic nephropathy susceptibility in patients with type 2 diabetes mellitus.
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and susceptibility to diabetic nephropathy in Chinese type 2 diabetic patients: a meta-analysis.
Methylenetetrahydrofolate reductase C677T polymorphism and type 2 diabetes mellitus in Chinese population: a meta-analysis of 29 case-control studies.
Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myocardial infarction.
Methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.
Methylenetetrahydrofolate reductase gene polymorphism, homocysteine and risk of macroangiopathy in Type 2 diabetes mellitus.
Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study.
Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease, and essential hypertension in the Czech population.
MTHFR (Ala 222 Val) polymorphism and AMI in patients with type II diabetes mellitus.
MTHFR gene polymorphism and diabetic retinopathy.
Peripheral Vascular Disease Susceptibility Based on Diabetes Mellitus and rs17367504 Polymorphism of the MTHFR Gene.
Physical Activity Level Influences MTHFR Gene Methylation Profile in Diabetic Patients.
Plasma homocysteine, methylenetetrahydrofolate reductase gene polymorphism and carotid intima-media thickness in Italian type 2 diabetic patients.
Plasma total homocysteine levels and methylenetetrahydrofolate reductase gene polymorphism in patients with type 2 diabetes mellitus.
Polymorphism in methylenetetrahydrofolate reductase gene: its impact on plasma homocysteine levels and carotid atherosclerosis in ESRD patients receiving hemodialysis.
Polymorphism of the methylenetetrahydrofolate reductase gene association with homocysteine and ischemic stroke in type 2 diabetes.
Prevalence of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Taiwanese patients with Type 2 diabetic mellitus.
Relationship between genetic polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase as risk factors for type 2 diabetes in Tunisian patients.
Relationship between MTHFR C677T and A1298C gene polymorphisms and complications of type 2 diabetes mellitus in an Emirati population.
Reply: Is the C677T Polymorphism in Methylenetetrahydrofolate Reductase Gene a Risk Factor for Diabetic Nephropathy or Diabetes Mellitus in a Chinese Population?
Risk Factors for Thrombosis Development in Mexican Patients.
Role of treatment-modifying MTHFR677C>T and 1298A>C polymorphisms in metformin-treated Puerto Rican patients with type-2 diabetes mellitus and peripheral neuropathy.
Screening the single nucleotide polymorphisms in patients with internal carotid artery stenosis by oligonucleotide-based custom DNA array.
Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and macro-albuminuria and progression of diabetic nephropathy among Iranians with type 2 diabetes mellitus.
The association between end-stage diabetic nephropathy and methylenetetrahydrofolate reductase genotype with macroangiopathy in type 2 diabetes mellitus.
The association between two common mutations C677T and A1298C in human methylenetetrahydrofolate reductase gene and the risk for diabetic nephropathy in type II diabetic patients.
The C677T methylenetetrahydrofolate reductase gene mutation and nephropathy in type 2 diabetes mellitus.
The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are associated with hyperhomocysteinemia and cardiovascular disease in hemodialysis patients.
The effect of MTHFR C677T polymorphism on type 2 diabetes mellitus with vascular complications in Chinese Han population: a meta-analysis.
The relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and diabetic nephropathy in Croatian type 2 diabetic patients.
The relationship between MTHFR gene polymorphisms, plasma homocysteine levels and diabetic retinopathy in type 2 diabetes mellitus.
The relationship between of ACE I/D and the MTHFR C677T polymorphisms in the pathophysiology of type 2 diabetes mellitus in a population of Brazilian obese patients.
Thermolabile methylenetetrahydrofolate reductase enzyme genotype is frequent in type 2 diabetic patients with normal fasting homocysteine levels.
[Levels of homocysteine and polymorphisms of homocysteine metabolism-related enzymes in patients with type 2 diabetes mellitus and coronary heart disease]
[Relationship between methylenetrahydrofolate reductase gene and ischemic stroke]
[The abnormal reaction to post methionine loading test in type diabetes with or without retinopathy]
[The association of methylenetetrahydrofolate reductase gene polymorphism with nephropathy in type 2 diabetes mellitus in Chinese]
[The relationship of methylenetetrahydrofolate reductase gene polymorphism and plasma homocysteine levels in type 2 diabetes mellitus patients with diabetic retinopathy]
Diabetes Mellitus, Type 1
Association of polymorphism of methylene-tetrahydro-folate-reductase with urinary albumin excretion rate in type 1 diabetes mellitus but not with preeclampsia, retinopathy, and preterm delivery.
Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms and protection from microvascular complications in adolescents with type 1 diabetes.
Methylenetetrahydrofolate reductase gene polymorphism and susceptibility to diabetic nephropathy in type 1 diabetes.
Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy in IDDM patients.
MTHFR gene polymorphism and diabetic nephropathy in type 1 diabetes.
Plasma total homocysteine levels in children with type 1 diabetes: relationship with vitamin status, methylene tetrahydrofolate reductase genotype, disease parameters and coronary risk factors.
Reduced total plasma homocyst(e)ine in children and adolescents with type 1 diabetes.
Diabetes Mellitus, Type 2
ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: A meta-analysis.
Additive Interaction of MTHFR C677T and MTRR A66G Polymorphisms with Being Overweight/Obesity on the Risk of Type 2 Diabetes.
Association between ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133), FTO (rs9939609) Genes Polymorphism and Type 2 Diabetes with Dyslipidemia.
Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.
Association Between Homocysteine Level and Methylenetetrahydrofolate Reductase Gene Polymorphisms in Type 2 Diabetes Accompanied by Dyslipidemia.
Association between MTHFR variant and diabetic neuropathy.
Association of ACE and MTHFR genetic polymorphisms with type 2 diabetes mellitus: Susceptibility and complications.
Association of genetic polymorphism of PPAR?-2, ACE, MTHFR, FABP-2 and FTO genes in risk prediction of type 2 diabetes mellitus.
Association of Kaphaja and Kapha-Pittaja Prakriti and methylenetetrahydrofolate reductase C677T allele with type 2 diabetes.
Association of methylenetetrahydrofolate reductase gene polymorphism with carotid arterial wall thickening and myocardial infarction risk in NIDDM.
Association of MTHFR and PPAR?2 gene polymorphisms in relation to type 2 diabetes mellitus cases among north Indian population.
Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility.
Association of tagging SNPs in the MTHFR gene with risk of type 2 diabetes mellitus and serum homocysteine levels in a Chinese population.
Association of the C677T Polymorphism in the Human Methylenetetrahydrofolate Reductase (MTHFR) Gene with the Genetic Predisposition for Type 2 Diabetes Mellitus in a Moroccan Population.
Association of Two Methylenetetrahydrofolate Reductase Polymorphisms (rs1801133, rs1801131) with the Risk of Type 2 Diabetes in South-East of Iran.
Differential contribution of MTHFR C677T variant to the risk of diabetic nephropathy in Lebanese and Bahraini Arabs.
Does the MTHFR C677T gene polymorphism indicate cardiovascular disease risk in type 2 diabetes mellitus patients?
Effect of MTHFR C677T genotype on survival in type 2 diabetes patients with end-stage diabetic nephropathy.
Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for diabetic nephropathy.
Factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase polymorphism C677T are not associated with coronary artery disease and type 2 diabetes mellitus in western Iran.
Genetic Predisposition for Development of Nephropathy in Type 2 Diabetes Mellitus.
Hyperhomocysteinemia and elevated ox-LDL in Tunisian type 2 diabetic patients: role of genetic and dietary factors.
Hypermethylation in the promoter of the
Impact of KCNJ11 rs5219, UCP2 rs659366, and MTHFR rs1801133 Polymorphisms on Type 2 Diabetes: A Cross-Sectional Study.
Interaction of eNOS polymorphism with MTHFR variants increase the risk of diabetic nephropathy and its progression in type 2 diabetes mellitus patients.
Interaction of MTHFR C677T polymorphism with smoking in susceptibility to diabetic nephropathy in Chinese men with type 2 diabetes.
Kaphaja, Kapha-Pittaja Prakriti, methylenetetrahydrofolate reductase C677T allele and type 2 diabetes.
Lack of association between carotid intima-media thickness and methylenetetrahydrofolate reductase gene polymorphism or serum homocysteine in non-insulin-dependent diabetes mellitus.
Methylenetetrahydrofolate Reductase (MTHFR) (C677T and A1298C) Polymorphisms and Vascular Complications in Patients with Type 2 Diabetes.
Methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and diabetic nephropathy susceptibility in patients with type 2 diabetes mellitus.
Methylenetetrahydrofolate reductase C677T polymorphism and type 2 diabetes mellitus in Chinese population: a meta-analysis of 29 case-control studies.
Methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.
Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy in NIDDM patients.
Methylenetetrahydrofolate reductase gene polymorphism, homocysteine and risk of macroangiopathy in Type 2 diabetes mellitus.
Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes.
Mild hyperhomocysteinemia, C677T polymorphism on methylenetetrahydrofolate reductase gene and the risk of macroangiopathy in type 2 diabetes: a prospective study.
MTHFR 677T variant contributes to diabetic nephropathy risk in Caucasian individuals with type 2 diabetes: A meta-analysis.
MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients.
MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients.
MTHFR gene C677T polymorphism and type 2 diabetic nephropathy in Asian populations: a meta-analysis.
MTHFR gene polymorphism as an exacerbation factor of diabetic nephropathy in type 2 diabetes. Analysis in Japanese male hemodialysis patients.
Mutation C677T of methylenetetrahydrofolate reductase gene is not associated with coronary artery disease, but possibly with albuminuria, in type 2 diabetic patients.
Physical Activity Level Influences MTHFR Gene Methylation Profile in Diabetic Patients.
Plasma homocysteine, methylenetetrahydrofolate reductase gene polymorphism and carotid intima-media thickness in Italian type 2 diabetic patients.
Plasma total homocysteine levels and methylenetetrahydrofolate reductase gene polymorphism in patients with type 2 diabetes mellitus.
Polymorphism of the methylenetetrahydrofolate reductase gene association with homocysteine and ischemic stroke in type 2 diabetes.
Prevalence of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Taiwanese patients with Type 2 diabetic mellitus.
Relationship between genetic polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase as risk factors for type 2 diabetes in Tunisian patients.
Relationship between MTHFR C677T and A1298C gene polymorphisms and complications of type 2 diabetes mellitus in an Emirati population.
Serum homocysteine, MTHFR gene polymorphism, and carotid intimal-medial thickness in NIDDM subjects.
Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and macro-albuminuria and progression of diabetic nephropathy among Iranians with type 2 diabetes mellitus.
The association between end-stage diabetic nephropathy and methylenetetrahydrofolate reductase genotype with macroangiopathy in type 2 diabetes mellitus.
The association between two common mutations C677T and A1298C in human methylenetetrahydrofolate reductase gene and the risk for diabetic nephropathy in type II diabetic patients.
The C677T methylenetetrahydrofolate reductase gene mutation and nephropathy in type 2 diabetes mellitus.
The effect of MTHFR C677T polymorphism on type 2 diabetes mellitus with vascular complications in Chinese Han population: a meta-analysis.
The MTHFR CT polymorphism confers a high risk for stroke in both homozygous and heterozygous T allele carriers with Type 2 diabetes.
The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: a meta-analysis.
The relationship between MTHFR gene polymorphisms, plasma homocysteine levels and diabetic retinopathy in type 2 diabetes mellitus.
The relationship between of ACE I/D and the MTHFR C677T polymorphisms in the pathophysiology of type 2 diabetes mellitus in a population of Brazilian obese patients.
Thermolabile methylenetetrahydrofolate reductase enzyme genotype is frequent in type 2 diabetic patients with normal fasting homocysteine levels.
[Association of methylenetetrahydrofolate reductase gene polymorphism with the development of myocardial infarction in patients with type 2 diabetes].
[Effects of methylenetetrahydrofolate reductase gene polymorphism and long-term exposure to organophosphorus pesticides on type 2 diabetes mellitus].
[Levels of homocysteine and polymorphisms of homocysteine metabolism-related enzymes in patients with type 2 diabetes mellitus and coronary heart disease]
[Methylenetetrahydrofolate reductase gene polymorphism in patients with type 2 diabetes]
[The association of methylenetetrahydrofolate reductase gene polymorphism with nephropathy in type 2 diabetes mellitus in Chinese]
[The relationship of methylenetetrahydrofolate reductase gene polymorphism and plasma homocysteine levels in type 2 diabetes mellitus patients with diabetic retinopathy]
Diabetes, Gestational
Associations Between Gestational Diabetes Mellitus Risk and Folate Status in Early Pregnancy and MTHFR C677T Polymorphisms in Chinese Women.
Evaluation of Gestational Diabetes Mellitus Risk in South Indian Women Based on MTHFR (C677T) and FVL (G1691A) Mutations.
No Association Between ADIPOQ or MTHFR Polymorphisms and Gestational Diabetes Mellitus in South African Women.
Risk factors of cerebral ischemia in infants born to mothers with gestational diabetes.
Diabetic Angiopathies
Genetic polymorphism of methylenetetrahydrofolate reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients.
MTHFR gene variant is not associated with diabetic nephropathy in Japanese.
The relationship between MTHFR gene polymorphisms, plasma homocysteine levels and diabetic retinopathy in type 2 diabetes mellitus.
Total plasma homocysteine is associated with hypertension in Type I diabetic patients.
[The relationship between the mutation of methylenetetrahydrofolate reductase gene 677C-->T and the diabetic microangiopathy]
Diabetic Nephropathies
A common mutation of the methylenetetrahydrofolate reductase gene as a risk factor for diabetic nephropathy.
A study on the correlation between MTHFR promoter methylation and diabetic nephropathy.
An updated meta-analysis of methylenetetrahydrofolate reductase gene 677C/T polymorphism with diabetic nephropathy and diabetic retinopathy.
Association between end-stage diabetic nephropathy and MTHFR (C677T and A1298C) gene polymorphisms.
Association Between MTHFR C677T Polymorphism and Diabetic Nephropathy in Chinese Population: Appraisal of a Recent Meta-analysis.
Association between MTHFR C677T polymorphism and diabetic nephropathy in the Chinese population: An updated meta-analysis and review.
Association between MTHFR C677T polymorphism and diabetic nephropathy or diabetes mellitus risk: need for clarification of data in a recent meta-analysis.
Association of methylenetetrahydrofolate reductase gene polymorphism and diabetic nephropathy in type 2 diabetes?
Blood S-adenosylmethionine concentrations and lymphocyte methylenetetrahydrofolate reductase activity in diabetes mellitus and diabetic nephropathy.
Differential contribution of MTHFR C677T variant to the risk of diabetic nephropathy in Lebanese and Bahraini Arabs.
Effect of MTHFR C677T genotype on survival in type 2 diabetes patients with end-stage diabetic nephropathy.
Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for diabetic nephropathy.
Genetic polymorphism of methylenetetrahydrofolate reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients.
Genetic Predisposition for Development of Nephropathy in Type 2 Diabetes Mellitus.
Interaction of eNOS polymorphism with MTHFR variants increase the risk of diabetic nephropathy and its progression in type 2 diabetes mellitus patients.
Interaction of MTHFR 1298C with ACE D Allele Augments the Risk of Diabetic Nephropathy in Western Iran.
Interaction of MTHFR C677T polymorphism with smoking in susceptibility to diabetic nephropathy in Chinese men with type 2 diabetes.
Is the C677T Polymorphism in Methylenetetrahydrofolate Reductase Gene a Risk Factor for Diabetic Nephropathy or Diabetes Mellitus in a Chinese Population?
Methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and diabetic nephropathy susceptibility in patients with type 2 diabetes mellitus.
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and susceptibility to diabetic nephropathy in Chinese type 2 diabetic patients: a meta-analysis.
METHYLENETETRAHYDROFOLATE REDUCTASE C677T POLYMORPHISM IN PATIENTS WITH HENOCH-SCHÖNLEIN PURPURA.
Methylenetetrahydrofolate reductase gene polymorphism and susceptibility to diabetic nephropathy in type 1 diabetes.
Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy in IDDM patients.
Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy in NIDDM patients.
Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphism is not related to diabetic nephropathy in Japanese Type 2 diabetic patients.
Methylenetetrahydrofolate reductase genetic polymorphism and the risk of diabetic nephropathy in type 2 diabetic patients.
Methyltetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy.
MTHFR 677T variant contributes to diabetic nephropathy risk in Caucasian individuals with type 2 diabetes: A meta-analysis.
MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients.
MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients.
MTHFR gene C677T polymorphism and type 2 diabetic nephropathy in Asian populations: a meta-analysis.
MTHFR gene polymorphism and diabetic nephropathy in type 1 diabetes.
MTHFR gene polymorphism as an exacerbation factor of diabetic nephropathy in type 2 diabetes. Analysis in Japanese male hemodialysis patients.
MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients.
MTHFR gene variant is not associated with diabetic nephropathy in Japanese.
No association between MTHFR gene polymorphism and diabetic nephropathy in Japanese type II diabetic patients with proliferative diabetic retinopathy.
Relationship between methylenetetrahydrofolate reductase (MTHFR) A1298C gene polymorphism and type 2 diabetic nephropathy risk: a meta-analysis.
Reply: Is the C677T Polymorphism in Methylenetetrahydrofolate Reductase Gene a Risk Factor for Diabetic Nephropathy or Diabetes Mellitus in a Chinese Population?
Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and macro-albuminuria and progression of diabetic nephropathy among Iranians with type 2 diabetes mellitus.
The association between end-stage diabetic nephropathy and methylenetetrahydrofolate reductase genotype with macroangiopathy in type 2 diabetes mellitus.
The association between two common mutations C677T and A1298C in human methylenetetrahydrofolate reductase gene and the risk for diabetic nephropathy in type II diabetic patients.
The C677T methylenetetrahydrofolate reductase gene mutation and nephropathy in type 2 diabetes mellitus.
The MTHFR promoter hypermethylation pattern associated with the A1298C polymorphism influences lipid parameters and glycemic control in diabetic patients.
The relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and diabetic nephropathy in Croatian type 2 diabetic patients.
The relationship of the methylenetetrahydrofolate reductase C677T gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy.
[Relationship between methylenetetrahydrofolate reductase gene polymorphism and diabetic nephropathy]
[The association of methylenetetrahydrofolate reductase gene polymorphism with nephropathy in type 2 diabetes mellitus in Chinese]
Diabetic Neuropathies
Association between MTHFR variant and diabetic neuropathy.
Association of MTHFR gene C677T mutation with diabetic peripheral neuropathy and diabetic retinopathy.
Diabetic neuropathy is not associated with homocysteine, folate, vitamin B12 levels, and MTHFR C677T mutation in type 2 diabetic outpatients taking metformin.
The MTHFR C677T polymorphism influences the efficacy of folic acid supplementation on the nerve conduction studies in patients with diabetic polyneuropathy; A randomized, double blind, placebo-controlled study.
Diabetic Retinopathy
A Meta-Analysis of Association between Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C/T Polymorphism and Diabetic Retinopathy.
An updated meta-analysis of methylenetetrahydrofolate reductase gene 677C/T polymorphism with diabetic nephropathy and diabetic retinopathy.
Association of MTHFR gene C677T mutation with diabetic peripheral neuropathy and diabetic retinopathy.
Diabetic retinopathy in Euro-Brazilian type 2 diabetic patients: relationship with polymorphisms in the aldose reductase, the plasminogen activator inhibitor-1 and the methylenetetrahydrofolate reductase genes.
Effect of polymorphisms of the MTHFR and APOE genes on susceptibility to diabetes and severity of diabetic retinopathy in Brazilian patients.
Effects of Ocufolin on retinal microvasculature in patients with mild non-proliferative diabetic retinopathy carrying polymorphisms of the MTHFR gene.
Faulty homocysteine recycling in diabetic retinopathy.
Genetic variants in ICAM1, PPARGC1A and MTHFR are potentially associated with different phenotypes of diabetic retinopathy.
Hypermethylation in the promoter of the
Improved conjunctival microcirculation in diabetic retinopathy patients with MTHFR polymorphisms after Ocufolin™ Administration.
Methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy risk: a meta-analysis of the Chinese population.
Methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy.
Methylenetrahydrofolate Reductase Gene C677T Polymorphism and Diabetic Retinopathy: a Meta-Analysis.
MTHFR gene polymorphism and diabetic retinopathy.
MTHFR gene polymorphism as a risk factor for diabetic retinopathy in type 2 diabetic patients without serum creatinine elevation.
MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients.
No association between MTHFR gene polymorphism and diabetic nephropathy in Japanese type II diabetic patients with proliferative diabetic retinopathy.
No association between the MTHFR gene polymorphism and diabetic retinopathy in type 2 diabetic patients without overt nephropathy.
The MTHFR promoter hypermethylation pattern associated with the A1298C polymorphism influences lipid parameters and glycemic control in diabetic patients.
The relationship between methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy: A meta-analysis in multiethnic groups.
The relationship between MTHFR gene polymorphisms, plasma homocysteine levels and diabetic retinopathy in type 2 diabetes mellitus.
[The relationship of methylenetetrahydrofolate reductase gene polymorphism and plasma homocysteine levels in type 2 diabetes mellitus patients with diabetic retinopathy]
DiGeorge Syndrome
A Bibliometric Analysis of Cleft Lip and Palate-Related Publication Trends From 2000 to 2017.
Diverticulitis
Role of acquired and hereditary thrombotic risk factors in colon ischemia of ambulatory patients.
Down Syndrome
Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect.
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.
Abnormal folate metabolism in mothers with Down syndrome offspring: Review of the literature.
Abnormal folic acid-homocysteine metabolism as maternal risk factors for Down syndrome in Japan.
Absence of association of fetal MTHFR C677T polymorphism with prenatal Down syndrome pregnancies.
Analysis of seven maternal polymorphisms of genes involved in homocysteine/folate metabolism and risk of Down syndrome offspring.
Association of methylenetetrahydrofolate reductase gene 677C > T polymorphism and Down syndrome.
C677T mutation in the 5,10-MTHFR gene and risk of Down syndrome in Italy.
Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China.
Evaluation of C677T and A1298C polymorphisms of the MTHFR gene as maternal risk factors for Down syndrome and congenital heart defects.
Fission Yeast Methylenetetrahydrofolate Reductase Ensures Mitotic and Meiotic Chromosome Segregation Fidelity.
Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for Down syndrome offspring: a meta-analysis.
Functional inference of methylenetetrahydrofolate reductase gene polymorphisms on enzyme stability as a potential risk factor for Down syndrome in Croatia.
Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil.
Increased MTHFR promoter methylation in mothers of Down syndrome individuals.
Investigating the impact of the Down syndrome related common MTHFR 677C>T polymorphism in the Danish population.
Maternal folate polymorphisms and the etiology of human nondisjunction.
Maternal methylenetetrahydrofolate reductase C677T polymorphism and down syndrome risk: a meta-analysis from 34 studies.
Maternal MTHFR polymorphism (677 C-T) and risk of Down's syndrome child: meta-analysis.
Maternal polymorphisms 677C-T and 1298A-C of MTHFR, and 66A-G MTRR genes: Is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk for having a child with Down syndrome?
Maternal polymorphisms for methyltetrahydrofolate reductase and methionine synthetase reductase and risk of children with Down syndrome.
Meta-analysis of Methylenetetrahydrofolate reductase maternal gene in Down syndrome: increased susceptibility in women carriers of the MTHFR 677T allele.
Methionine synthase (MTR) 2756 (A --> G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome.
Methylenetetrahydrofolate Reductase Dimer Configuration as a Risk Factor for Maternal Meiosis I-Derived Trisomy 21.
Methylenetetrahydrofolate reductase enzyme polymorphisms as maternal risk for Down syndrome among Turkish women.
Methylenetetrahydrofolate reductase gene polymorphisms and their association with trisomy 21.
Methylenetetrahydrofolate reductase polymorphism in the etiology of Down syndrome.
Methylenetetrahydrofolate reductase polymorphism is not risk factor for Down syndrome in North India.
Methylenetetrahydrofolate reductase polymorphisms C677T and A1298C as maternal risk factors for Down syndrome in Jordan.
MTHFR 677 TT genotype in a mother and her child with Down syndrome, atrioventricular canal and exstrophy of the bladder: implications of a mutual genetic risk factor?
MTHFR 677C-->T and 1298A-->C polymorphisms in children with Down syndrome and acute myeloid leukemia in Brazil.
MTHFR 677C-T polymorphism is not excluded as maternal risk for Down syndrome among Turkish women.
MTHFR and RFC-1 gene polymorphisms and the risk of Down syndrome in Italy.
MTHFR C677T and A1298C polymorphisms are risk factors for Down's syndrome in Indian mothers.
MTHFR C677T and A1298C polymorphisms as a risk factor for congenital heart defects in Down syndrome.
MTHFR Gene variants C677T, A1298C and association with Down syndrome: A Case-control study from South India.
MTHFR genetic polymorphism as a risk factor in Egyptian mothers with Down syndrome children.
MTHFR promoter hypermethylation may lead to congenital heart defects in Down syndrome.
MTRR and MTHFR polymorphism: link to Down syndrome?
No association between common polymorphisms in genes of folate and homocysteine metabolism and the risk of Down's syndrome among French mothers.
Polymorphisms in folate and homocysteine metabolizing genes and chromosome damage in mothers of Down syndrome children.
Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China.
Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome.
Polymorphisms of the MTHFR gene in mothers of children with trisomy 21 (Down syndrome) in a Polish population.
Preferential transmission of the MTHFR 677 T allele to infants with Down syndrome: implications for a survival advantage.
Prevalence of methylenetetrahydrofolate reductase 677 C-T polymorphism among mothers of Down syndrome children.
Prevalence of MTHFR C677T polymorphism in north Indian mothers having babies with Trisomy 21 Down syndrome.
Relationship between polymorphisms in genes involved in homocysteine metabolism and maternal risk for Down syndrome in Brazil.
Risk of Down syndrome conferred by MTHFR C677T polymorphism: Ethnic variations.
Role of folate-homocysteine pathway gene polymorphisms and nutritional cofactors in Down syndrome: A triad study.
Screening of six polymorphisms related with folate metabolism in parents of individuals with Down syndrome.
The association between maternal methylenetetrahydrofolate reductase C677T and A1298C polymorphism and birth defects and adverse pregnancy outcomes.
The biochemical structure and function of methylenetetrahydrofolate reductase provide the rationale to interpret the epidemiological results on the risk for infants with Down syndrome.
The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects.
The impact of folate pathway polymorphisms combined to nutritional deficiency as a maternal predisposition factor for Down syndrome.
Vitamin D3 increases the Caspase-3 p12, MTHFR, and P-glycoprotein reducing amyloid-?42 in the kidney of a mouse model for Down syndrome.
[Association of MTHFR and MTRR genes polymorphisms with non-disjunctions of chromosomes 18 and 21].
[Folate gene polymorphism and the risk of Down syndrome pregnancies in young Chinese women]
[Rapid screening for MTHFR gene 677C>T polymorphism in Down syndrome using high resolution melting curve and pyrosequencing.]
[The relationship between polymorphism of gene involved in folate metabolism, homocysteine level and risk of Down syndrome.]
[The significance of folate metabolism in complications of pregnant women].
Drug-Related Side Effects and Adverse Reactions
Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation.
Pharmacogenetics and pediatric cancer.
SLCO1B1 Polymorphisms are Associated With Drug Intolerance in Childhood Leukemia Maintenance Therapy.
Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients.
[Pharmacogenomics of methrotexate: a strategy for a customized therapeutic scheme for patients with rheumatoid arthritis]
Dry Eye Syndromes
Angiotensin converting enzyme and methylenetetrahydrofolate reductase gene variations in fibromyalgia syndrome.
Ductus Arteriosus, Patent
Correlation Between Methyltetrahydrofolate Reductase (MTHFR) Polymorphisms and Isolated Patent Ductus Arteriosus in Taiwan.
Genomics and Epigenomics of Congenital Heart Defects: Expert Review and Lessons Learned in Africa.
Maternal and offspring MTHFR gene C677T polymorphism as predictors of congenital atrial septal defect and patent ductus arteriosus.
Dyskinesias
5,10-methylenetetrahydrofolate reductase C677T gene polymorphism can influence age at onset of Parkinson's disease.
Dyslipidemias
Association between ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133), FTO (rs9939609) Genes Polymorphism and Type 2 Diabetes with Dyslipidemia.
Association Between Homocysteine Level and Methylenetetrahydrofolate Reductase Gene Polymorphisms in Type 2 Diabetes Accompanied by Dyslipidemia.
Diabetic neuropathy is not associated with homocysteine, folate, vitamin B12 levels, and MTHFR C677T mutation in type 2 diabetic outpatients taking metformin.
Impact of KCNJ11 rs5219, UCP2 rs659366, and MTHFR rs1801133 Polymorphisms on Type 2 Diabetes: A Cross-Sectional Study.
Individual and Joint Associations of Methylenetetrahydrofolate Reductase C677T Genotype and Plasma Homocysteine With Dyslipidemia in a Chinese Population With Hypertension.
Is there additional effect of MTHFR C677T mutation on lipid abnormalities in renal allograft recipients?
Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study.
Methylenetetrahydrofolate reductase C677T gene polymorphism and the association with dyslipidemia in type 2 diabetic Palestinian patients.
Modeling premature occurrence of acute coronary syndrome with atherogenic and thrombogenic risk factors and gene markers in extended families.
Possible roles of methylenetetrahydrofolate reductase polymorphism and folate status in patients with early hepatitis C virus genotype 4.
Supplementation with Watermelon Extract Reduces Total Cholesterol and LDL Cholesterol in Adults with Dyslipidemia under the Influence of the MTHFR C677T Polymorphism.
Dyspnea
High Circulating Folate and Vitamin B-12 Concentrations in Women During Pregnancy Are Associated with Increased Prevalence of Atopic Dermatitis in Their Offspring.
Eclampsia
High frequency of methylenetetrahydrofolate reductase 677TT genotype in Hungarian HELLP syndrome patients determined by quantitative real-time PCR.
Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe.
[Folic acid levels, homocysteine and polymorphism of methylenetetrahydrofolate reductase enzyme (MTHFR) in patients with pre-eclampsia and eclampsia]
Eczema
Neonatal folate, homocysteine, vitamin B12 levels and methylenetetrahydrofolate reductase variants in childhood asthma and eczema.
Ehlers-Danlos Syndrome
[Investigation of detoxification polymorphisms genes, methylenetetrahydrofolate-reductase (MTHFR) and P53 in the radiosensitive human cells]
Embolic Stroke
Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype.
MTHFR Gene Polymorphisms Prevalence and Cardiovascular Risk Factors Involved in Cardioembolic Stroke Type and Severity.
Embolism
Acute renal infarction associated with homozygous methylenetetrahydrofolate reductase mutation C677T and IgA beta-2-glycoprotein antibodies.
Tricuspid valve thrombus and pulmonary embolus in an infant with homozygous thermolabile methylenetetrahydrofolate reductase and heterozygous prothrombin G20210A variant.
Embryo Loss
Genotypes of the C677T and A1298C polymorphisms of the MTHFR gene as a cause of human spontaneous embryo loss.
Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos.
Encephalocele
Amniotic fluid homocysteine levels, 5,10-methylenetetrahydrafolate reductase genotypes, and neural tube closure sites.
C677T mutation in the MTHFR gene was not found in patients with frontoethmoidal encephalocele in East Java, Indonesia.
Evidence of gene-gene interactions between MTHFD1 and MTHFR in relation to anterior encephalocele susceptibility in Northeast India.
Encephalomalacia
Diffuse multicystic encephalomalacia in a preterm baby due to homozygous methylenetetrahydrofolate reductase 677 C-->T mutation.
End Stage Liver Disease
MTHFR C677T polymorphism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption.
Endometrial Neoplasms
Dietary folate intake, MTHFR genetic polymorphisms, and the risk of endometrial cancer among Chinese women.
Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities.
Endometrial carcinoma in tamoxifen-treated breast cancer patient: clinicopathological, immunohistochemical, and genetic analysis.
Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility.
Methylenetetrahydrofolate reductase gene polymorphism in endometrial cancer: A systematic review and meta-analysis.
No association between MTHFR 677 C->T or 1298 A->C polymorphisms and endometrial cancer risk.
Endometriosis
Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.
Eosinophilia
MTHFR C677T polymorphism and anatomopathological characteristics with prognostic significance in sporadic colorectal cancer.
Transient severe eosinophilia precipitating massive venous thrombosis in a patient with hereditary thrombophilia.
Epilepsy
A common mutation in the methylenetetrahydrofolate reductase gene is a determinant of hyperhomocysteinemia in epileptic patients receiving anticonvulsants.
A high frequency of the MTHFR 677C>T polymorphism in Scottish women with epilepsy: possible role in pathogenesis.
Analysis of the MTHFR C677T variant with migraine phenotypes.
Antiepileptic drugs, hyperhomocysteinemia and B-vitamins supplementation in patients with epilepsy.
Are the methylenetetrahydrofolate reductase 1298 and 677 gene polymorphisms related to optic glioma and hamartoma risk in neurofibromatosis type 1 patients?
Association between methylenetetrahydrofolate reductase C677T polymorphism and epilepsy susceptibility: A meta-analysis.
Association of MTHFR gene polymorphisms with migraine in North Indian population.
Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk.
Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis.
Associations between genetic variation in one-carbon metabolism and leukocyte DNA methylation in valproate-treated patients with epilepsy.
Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.
Effects of antiepileptic drug monotherapy on one-carbon metabolism and DNA methylation in patients with epilepsy.
Effects of dietary folate intake on migraine disability and frequency.
Effects of MTHFR and ABCC2 gene polymorphisms on antiepileptic drug responsiveness in Jordanian epileptic patients.
Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine.
Frequency of the C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene in patients with migraine with or without aura - a preliminary report.
Genetic biomarkers for migraine.
Genetic Polymorphisms in Enzymes Involved in One-Carbon Metabolism and Anti-epileptic Drug Monotherapy on Homocysteine Metabolism in Patients With Epilepsy.
Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura.
Influence of MTHFR genotype on contingent negative variation and MRI abnormalities in migraine.
Influence of the MTHFR genotype on the rate of malformations following exposure to antiepileptic drugs in utero.
Interictal epileptiform discharges on electroencephalography in children with methylenetetrahydrofolate reductase (MTHFR) polymorphisms.
Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease.
Lack of association between the MTHFR C677T variant and migraine with aura in an older population: Could selective survival play a role?
Methylenetetrahydrofolate reductase (MTHFR) deficiency and infantile epilepsy.
Methylenetetrahydrofolate reductase 677C > T mutation and epilepsy.
Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to epilepsy.
Migraine and coronary artery disease: an open study on the genetic polymorphism of the 5, 10 methylenetetrahydrofolate (MTHFR) and angiotensin I-converting enzyme (ACE) genes.
Migraine mediates the influence of C677T MTHFR genotypes on ischemic stroke risk with a stroke-subtype effect.
MTHFR 677C>T and ACE D/I Polymorphisms in Migraine: A Systematic Review and Meta-Analysis.
MTHFR C677T Genotype as a Risk factor for Epilepsy Including Post-Traumatic Epilepsy in a Representative Military Cohort.
MTHFR C677T polymorphism and migraine with aura.
MTHFR T677 homozygosis influences the presence of aura in migraineurs.
Pregnancy outcomes in women with epilepsy and MTHFR mutations supplemented with methylated folate and methylcobalamin (methylated B12).
Role of folic acid depletion on homocysteine serum level in children and adolescents with epilepsy and different MTHFR C677T genotypes.
Role of plasma homocysteine levels and MTHFR polymorphisms on IQ scores in children and young adults with epilepsy treated with antiepileptic drugs.
Screening for C677T and A1298C MTHFR polymorphisms in patients with epilepsy and risk of hyperhomocysteinemia.
Targeting MTHFR for the treatment of migraines.
Testing of variants of the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association with migraine with aura.
The 677C --> T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in epileptic patients affected by systemic lupus erythematosus.
The C677T polymorphism in MTHFR is not associated with migraine in Portugal.
The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura.
The Role of the MTHFR Gene in Migraine.
Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele.
Update on the genetics of migraine.
[Mutation of MTHFR gene as marker of endothelial dysfunction in patients diagnosed of migraine with aura.]
Epilepsy, Generalized
MTHFR homozygous mutation and additional risk factors for cerebral infarction in a large Italian family.
Epilepsy, Post-Traumatic
MTHFR C677T Genotype as a Risk factor for Epilepsy Including Post-Traumatic Epilepsy in a Representative Military Cohort.
Epilepsy, Tonic-Clonic
Effects of MTHFR and ABCC2 gene polymorphisms on antiepileptic drug responsiveness in Jordanian epileptic patients.
Epileptic Syndromes
Adolescence/adult onset MTHFR deficiency may manifest as isolated and treatable distinct neuro-psychiatric syndromes.
Equinus Deformity
Whole genome sequencing identifies ANXA3 and MTHFR mutations in a large family with an unknown equinus deformity associated genetic disorder.
Erectile Dysfunction
Role of Methylenetetrahydrofolate Reductase Gene Polymorphisms (C677T, A1298C, and G1793A) in the Development of Early Onset Vasculogenic Erectile Dysfunction.
The relationship between the C677T polymorphism of the MTHFR gene and serum levels of luteinizing hormone in males with erectile dysfunction.
Treatment of Erectile Dysfunction Due to C677T Mutation of the MTHFR Gene with Vitamin B6 and Folic acid in Patients Non Responders to PDE5i.
Esophageal Neoplasms
Advances in cancer epidemiology in Japan.
DNA Repair Gene and MTHFR Gene Polymorphisms as Prognostic Markers in Locally Advanced Adenocarcinoma of the Esophagus or Stomach Treated with Cisplatin and 5-Fluorouracil-Based Neoadjuvant Chemotherapy.
Folate intake, methylenetetrahydrofolate reductase polymorphisms in association with the prognosis of esophageal squamous cell carcinoma.
Folate intake, methylenetetrahydrofolate reductase polymorphisms, and risk of esophageal cancer.
Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan.
Genetic polymorphism of MTHFR A1298C and esophageal cancer susceptibility: a meta-analysis.
Genetic polymorphisms and esophageal cancer risk.
Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism, and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls.
Interaction of methylenetetrahydrofolate reductase C677T, cytochrome P4502E1 polymorphism and environment factors in esophageal cancer in Kazakh population.
LncRNA HOTAIR-mediated MTHFR methylation inhibits 5-fluorouracil sensitivity in esophageal cancer cells.
Meta-analysis of the Relationship between the Metholenetetrahydrofolate Reductase C677T Genetic Polymorphism, Folate Intake and Esophageal Cancer.
Methylene tetrahydrofolate reductasel reductase C677T polymorphisms and esophageal cancer susceptibility: A meta-analysis based on Chinese Han population.
Methylenetetrahydrofolate Reductase Genetic Polymorphisms and Esophageal Squamous Cell Carcinoma Susceptibility: A Meta-analysis of Case-control Studies.
Methylenetetrahydrofolate reductase genetic polymorphisms and esophageal squamous cell carcinoma susceptibility: A meta-analysis of case-control studies.
Methylenetetrahydrofolate Reductase Polymorphisms and Susceptibility to Esophageal Cancer in Chinese Populations: a Meta-analysis.
Pharmacogenetics in esophageal cancer.
Relationship between MTHFR Gene Polymorphisms and Gastrointestinal Tumors Development: Perspective from Eastern Part of Turkey.
Relationship between the Methylation of Folic Acid Metabolism-Related Genes and the Incidence and Prognosis of Esophageal Cancer among Ethnic Kazakhs.
Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer.
Susceptibility to gastric cardia adenocarcinoma and genetic polymorphisms in methylenetetrahydrofolate reductase in an at-risk Chinese population.
The Methylenetetrahydrofolate Reductase C677T Polymorphism Influences Risk of Esophageal Cancer in Chinese.
[A case-control study on the polymorphisms of methylenetetrahydrofolate reductase 1298A-->C and susceptibility of esophageal cancer]
[Study on the ingestion of folate and polymorphism of MTHFR C677T with esophageal cancer in Xinjiang Kazakh]
Esophageal Squamous Cell Carcinoma
Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism and folate intake in esophageal squamous cell carcinoma.
Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism in esophageal squamous cell carcinoma.
Association between a microRNA-214 binding site polymorphism in the methylenetetrahydrofolate reductase gene and esophageal squamous cell carcinoma.
Diet folate, DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma.
Folate intake, methylenetetrahydrofolate reductase polymorphisms in association with the prognosis of esophageal squamous cell carcinoma.
Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis.
Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review).
Genetic polymorphisms in folate- metabolizing enzymes and risk of gastroesophageal cancers: a potential nutrient-gene interaction in cancer development.
Genetic Variants in MTHFR Gene Predict ? 2 Radiation Pneumonitis in Esophageal Squamous Cell Carcinoma Patients Treated with Thoracic Radiotherapy.
Genetic variations in MTHFR and esophageal squamous cell carcinoma susceptibility in Chinese Han population.
Head and neck cancer susceptibility: a genetic marker in the methylenetetrahydrofolate reductase gene.
Methylenetetrahydrofolate reductase C677T polymorphism and predisposition towards esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population.
Methylenetetrahydrofolate Reductase Genetic Polymorphisms and Esophageal Squamous Cell Carcinoma Susceptibility: A Meta-analysis of Case-control Studies.
Methylenetetrahydrofolate reductase genetic polymorphisms and esophageal squamous cell carcinoma susceptibility: A meta-analysis of case-control studies.
Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population.
MTHFR C677T genetic polymorphism in combination with serum vitamin B2, B12 and aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and esophageal precancerous lesions: a case-control study.
Polymorphisms of MTHFR and susceptibility to oesophageal adenocarcinoma in a Caucasian United Kingdom population.
Serum folate, MTHFR C677T polymorphism and esophageal squamous cell carcinoma risk.
Systematic Review on the Relationship between Genetic Polymorphisms of Methylenetetrahydrofolate Reductase and Esophageal Squamous Cell Carcinoma.
[Correlation of aberrant methylation of MGMT gene to MTHFR C677T genetic polymorphisms in esophageal squamous cell carcinoma]
Esophagitis
Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.
Esophagitis, Peptic
Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.
Essential Hypertension
A 31 year old woman with essential hypertension grade III and branch retinal vein occlusion with homozygous C677T MTHFR hyperhomocysteinemia and high Lp(a) levels.
A case-control study of the association between the MTHFR gene and essential hypertension in Asian Indians.
A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients--a family-based association study.
A common mutation in methylenetetrahydrofolate reductase gene among the Japanese population.
Association between Hcy levels and the CBS844ins68 and MTHFR C677T polymorphisms with essential hypertension.
Association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and essential hypertension: a systematic review and meta-analysis.
Association between the MTHFR C677T gene polymorphism and essential hypertension in South West Cameroon.
Associations of methylenetetrahydrofolate reductase C677T genotype with blood pressure levels in Chinese population with essential hypertension.
Combined Effect of Factor V Leiden, MTHFR, and Angiotensin-Converting Enzyme (Insertion/Deletion) Gene Mutations in Hypertensive Adult Individuals: A Population-Based Study from Sivas and Canakkale, Turkey.
Effect of enalapril on plasma homocysteine levels in patients with essential hypertension.
Fingertips ischemia, nephroangiosclerosis, and focal segmental glomerulosclerosis: is genetic thrombophilia the unique explanation?
Functional Polymorphism rs13306560 of the MTHFR Gene Is Associated With Essential Hypertension in a Mexican-Mestizo Population.
Hyperhomocysteinemia but not MTHFR genotype is associated with young-onset essential hypertension.
Individual and Joint Associations of Methylenetetrahydrofolate Reductase C677T Genotype and Plasma Homocysteine With Dyslipidemia in a Chinese Population With Hypertension.
Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?
Methylenetetrahydrofolate reductase C677T gene polymorphism and essential hypertension: A meta-analysis of 10,415 subjects.
Methylenetetrahydrofolate reductase gene polymorphisms in essential hypertension relation: with the development of hypertensive end-stage renal disease.
Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease, and essential hypertension in the Czech population.
Polymorphism of MTHFR C677T Gene and the Associations with the Severity of Essential Hypertension in Northern Chinese Population.
The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels.
The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor.
The methylentetrahydrofolate reductase gene variant (C677T) as a risk factor for essential hypertension in Caucasians.
The relationship between MTHFR C677T gene polymorphism and essential hypertension in a sample of an Algerian population of Oran city.
[A case-control study on the relationship between abnormal homocysteine metabolism and essential hypertension]
[Study of the genetic markers of thrombosis in hypertensive patients of the title population in the Republic of Mordovia]
Essential Tremor
Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in patients with essential tremor in Turkey.
Lack of association between methylenetetrahydrofolate reductase gene variants & essential tremor in Han Chinese.
Exanthema
Methylenetetrahydrofolate reductase (MTHFR) deficiency presenting as a rash.
Exfoliation Syndrome
MTHFR and MTHFD1 gene polymorphisms are not associated with pseudoexfoliation syndrome in South Indian population.
Factor V Deficiency
Expanded carrier screening in gamete donors of Venezuela.
Factor XII Deficiency
Retinal vein occlusion in child with rare mutations in genes for thrombophilia.
Familial Mediterranean Fever
Do MTHFR mutations kick in during familial mediterranean fever attacks?
Fatty Liver
Associations between Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms and Non-Alcoholic Fatty Liver Disease (NAFLD) Risk: A Meta-Analysis.
Genetic variants in the MTHFR are not associated with fatty liver disease.
MTHFR 677C/T and 1298A/C mutations and non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) and MTHFR 1298A > C gene polymorphism.
Plasmatic higher levels of homocysteine in non-alcoholic fatty liver disease (NAFLD).
The methylenetetrahydrofolate reductase genotype 677CT and non-alcoholic fatty liver disease have a synergistic effect on the increasing homocysteine levels in subjects from Chongqing, China.
[Association of hyperhomocysteinemia with liver steatosis in patients with chronic hepatitis C].
Fetal Alcohol Spectrum Disorders
High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.
High intake of folic acid disrupts embryonic development in mice.
Moderate Folic Acid Supplementation in Pregnant Mice Results in Behavioral Alterations in Offspring with Sex-Specific Changes in Methyl Metabolism.
Fetal Death
Methylenetetrahydrofolate reductase C677T polymorphism and pregnancy complications.
MTHFR (C677T) polymorphism and PR (PROGINS) mutation as genetic factors for preterm delivery, fetal death and low birth weight: A Northeast Indian population based study.
MTHFR genetic polymorphism and the risk of intrauterine fetal death in Polish women.
The investigation of hereditary and acquired thrombophilia risk factors in the development of complications in pregnancy in Croatian women.
Unexplained fetal loss: the fetal side of thrombophilia.
[Hyperhomocysteinemia and pregnancy complications]
Fetal Growth Retardation
Absence of association of thrombophilia polymorphisms with intrauterine growth restriction.
Association of MTHFR 677C>T polymorphism with IUGR and placental abruption risk: A systematic review and meta-analysis.
Association of MTHFR A1298C polymorphism (but not of MTHFR C677T) with elevated homocysteine levels and placental vasculopathies.
Carriage of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism does not influence the first and second trimester uterine artery Doppler flow.
Combined heterozygosity for methylenetetrahydrofolate reductase (MTHFR) mutations C677T and A1298C is associated with abruptio placentae but not with intrauterine growth restriction.
Factor V Leiden, Prothrombin and MTHFR Mutation in Patients with Preeclamsia, Intrauterine Growth Restriction and Placental Abruption.
Familial thrombophilia and the occurrence of fetal growth restriction.
Genetic factors in fetal growth restriction and miscarriage.
How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review.
Inherited thrombophilia in pregnant women with intrauterine growth restriction.
Intrauterine growth restriction and genetic predisposition to thrombophilia.
Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice.
The association between maternal methylenetetrahydrofolate reductase C677T and A1298C polymorphism and birth defects and adverse pregnancy outcomes.
[Hyperhomocysteinemia and pregnancy complications]
Fibromyalgia
Angiotensin converting enzyme and methylenetetrahydrofolate reductase gene variations in fibromyalgia syndrome.
Investigation of ACE rs4646994, MTHFR rs1801133 and VDR rs2228570 Genotypes in Jordanian Patients with Fibromyalgia Syndrome.
Folic Acid Deficiency
A case report of branch retinal artery occlusion in a teenager due to hyperhomocysteinaemia; the interplay of genetic and nutritional defects.
Association of neural tube defects with maternal alterations and genetic polymorphisms in one-carbon metabolic pathway.
Effects of folic acid deficiency and MTHFR C677T polymorphism on spontaneous and radiation-induced micronuclei in human lymphocytes.
Factor V Leiden, prothrombin 20210A, methylenetetrahydrofolate reductase 677T, and population genetics.
Genetic polymorphisms and folate status.
Interactions Between MTHFR C677T - A1298C Variants and Folic Acid Deficiency Affect Breast Cancer Risk in a Chinese Population.
Lack of association of methylenetetrahydrofolate reductase 677C>T mutation with coronary artery disease in a Pakistani population.
Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes.
Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors.
The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro.
[Assessment of the sufficiency of Moscow population with folic acid, depending on the combined effect of polymorphism of MTHFR and FTO genes].
[Relationship of plasma homocysteine and folic acid levels and 5,10-methylenetetrahydrofolate reductase gene mutation with venous thromboembolism]
Foramen Ovale, Patent
Cerebrovascular risk factors and MRI abnormalities in migraine.
Could genetic analysis be useful in reducing cerebrovascular risk in hypertensive subjects with hyperhomocysteinemia and patent foramen ovale? A 2-year follow-up study.
Frequency of the C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene in patients with migraine with or without aura - a preliminary report.
Stroke in Young Military Men With Heterozygous for MTHFR Gene Mutation or Factor V Leiden Gene Mutation Associated With Patent Foramen Ovale: Report of Two Cases and Therapeutic Strategy.
Gait Disorders, Neurologic
Rapidly progressive psychotic symptoms triggered by infection in a patient with methylenetetrahydrofolate reductase deficiency: a case report.
Gallbladder Neoplasms
Association of Methylenetetrahydrafolate Reductase Gene Polymorphism (MTHFR) in Patients with Gallbladder Cancer.
No Association of Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism in Susceptibility to Gallbladder Cancer.
Gastritis, Atrophic
Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis patients without Helicobacter pylori infection: a case control study.
Homocysteine Levels in Chronic Gastritis and Other Conditions: Relations to Incident Cardiovascular Disease and Dementia.
MTHFR polymorphisms involved in vitamin B12 deficiency associated with atrophic gastritis.
Gastrointestinal Diseases
[677T mutation of the MTHFR gene in adenomas and colorectal cancer in a population sample from the Northeastern Mexico. Preliminary results]
Gastrointestinal Neoplasms
Effect of MTHFR Polymorphisms on Gastrointestinal Cancer Risk in Italy.
Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.
Methylenetetrahydrofolate reductase polymorphism is associated with folate pool in gastrointestinal cancer tissue.
Polymorphisms in folic acid metabolism genes do not associate with cancer cachexia in Japanese gastrointestinal patients.
The combination of methylenehydrofolate reductase C677T polymorphism screening and gastrointestinal tumor markers detection may be an early screening method for gastrointestinal cancer related to helicobacter pylori infection.
Gastroschisis
Effects of MTHFR c.677C>T, F2 c.20210G>A and F5 Leiden Polymorphisms in Gastroschisis.
Genetic predispositions for thromboembolism as a possible etiology for gastroschisis.
Gaucher Disease
A newborn case with perinatal-lethal Gaucher disease due to R463H homozygosity complicated by C677T homozygosity in the MTHFR gene.
Genetic Diseases, Inborn
Heparin for the treatment of thrombosis in neonates.
Methylenetetrahydrofolate reductase polymorphisms and risk of sporadic and hereditary colorectal cancer with or without microsatellite instability.
Whole genome sequencing identifies ANXA3 and MTHFR mutations in a large family with an unknown equinus deformity associated genetic disorder.
[No association between MTHFR 677C>T polymorphism and ovarian cancer risk in BRCA1 mutation carriers in Wielkopolska region].
Gestational Trophoblastic Disease
667C>T and 1298A>C polymorphisms of MTHFR do not predict response to methotrexate in patients with gestational trophoblastic neoplasia.
Presence of the methylenetetrahydrofolate reductase gene polymorphism MTHFR C677T in molar tissue but not maternal blood predicts failure of methotrexate treatment for low-risk gestational trophoblastic neoplasia.
Glaucoma
Association of MTHFR C677T and A1298C Polymorphisms with Glaucoma Risk: a Systematic Review Meta-Analysis based 42 Case-Control Studies.
Association of MTHFR C677T polymorphism with primary open angle glaucoma: a Meta-analysis based on 18 case-control studies.
Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population.
C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with primary closed angle glaucoma.
Correlation between MTHFR polymorphisms and glaucoma: A meta-analysis.
Lack of Association between the C677T Single Nucleotide Polymorphism of the MTHFR Gene and Glaucoma in Iranian Patients.
Methylenetetrahydrofolate reductase 677 C-T and homocysteine levels in Turkish patients with pseudoexfoliation.
Methylenetetrahydrofolate reductase gene polymorphisms c.677C/T and c.1298A/C are not associated with open angle glaucoma.
Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma.
MTHFR C677T predisposes to POAG but not to PACG in a North Indian population: a case control study.
MTHFR gene C677T and A1298C polymorphisms and homocysteine levels in primary open angle and primary closed angle glaucoma.
Plasma homocysteine in patients with retinal vein occlusion.
Plasma homocysteine, MTHFR gene mutation, and open-angle glaucoma.
Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis.
Plasma Homocysteine, Serum Folic Acid, Serum Vitamin B12, Serum Vitamin B6, MTHFR, and Risk of Normal-Tension Glaucoma.
The C677T variant in the methylenetetrahydrofolate reductase gene is not associated with disease in cohorts of pseudoexfoliation glaucoma and primary open-angle glaucoma patients from Iowa.
Glaucoma, Angle-Closure
Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population.
C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with primary closed angle glaucoma.
MTHFR C677T predisposes to POAG but not to PACG in a North Indian population: a case control study.
Glaucoma, Open-Angle
Association between MTHFR C677T polymorphism and primary open-angle glaucoma: a meta-analysis.
Association of MTHFR C677T and A1298C Polymorphisms with Glaucoma Risk: a Systematic Review Meta-Analysis based 42 Case-Control Studies.
Association of MTHFR C677T polymorphism with primary open angle glaucoma: a Meta-analysis based on 18 case-control studies.
Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population.
C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with primary closed angle glaucoma.
Homocysteine and risk of open-angle glaucoma.
Homocysteine, B Vitamins, Methylenetetrahydrofolate Reductase Gene, and Risk of Primary Open-Angle Glaucoma: A Meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphisms c.677C/T and c.1298A/C are not associated with open angle glaucoma.
Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma.
MTHFR C677T homozygous mutation in a patient with pigmentary glaucoma and central retinal vein occlusion.
MTHFR C677T predisposes to POAG but not to PACG in a North Indian population: a case control study.
MTHFR gene C677T and A1298C polymorphisms and homocysteine levels in primary open angle and primary closed angle glaucoma.
Plasma homocysteine, MTHFR gene mutation, and open-angle glaucoma.
The C677T variant in the methylenetetrahydrofolate reductase gene is not associated with disease in cohorts of pseudoexfoliation glaucoma and primary open-angle glaucoma patients from Iowa.
The Effect of MTHFR Ala222Val Polymorphism on Open-angle Glaucoma: A Meta-analysis.
Glioblastoma
Genome-wide Hypomethylation in Human Glioblastomas Associated with Specific Copy Number Alteration, Methylenetetrahydrofolate Reductase Allele Status, and Increased Proliferation.
Intranasal perillyl alcohol therapy improves survival of patients with recurrent glioblastoma harboring mutant variant for MTHFR rs1801133 polymorphism.
The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiforme.
The methylenetetrahydrofolate reductase (MTHFR) variant c.677C>T (A222V) influences overall survival of patients with glioblastoma multiforme.
Glioma
ACE I/D sequence variants but not MTHFR C677T, is strongly linked to malignant glioma risk and its variant DD genotype may act as a promising predictive biomarker for overall survival of glioma patients.
Association between MTHFR 677C>T polymorphism and risk of gliomas: evidence from a meta-analysis.
Association of the MTHFR C677T polymorphism with primary brain tumor risk.
C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and high-grade gliomas.
Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults.
Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma.
Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels.
MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review.
Polo-like kinase 1 (PLK1)-dependent phosphorylation of methylenetetrahydrofolate reductase (MTHFR) regulates replication via histone methylation.
Glomerulonephritis, Membranous
Arterial thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase C677T mutation in childhood membranous glomerulonephritis.
Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase A1298C mutation in adult membranous glomerulonephritis.
Glomerulosclerosis, Focal Segmental
METHYLENETETRAHYDROFOLATE REDUCTASE C677T POLYMORPHISM IN PATIENTS WITH HENOCH-SCHÖNLEIN PURPURA.
Methylenetetrahydrofolate reductase polymorphism in childhood primary focal segmental glomerulosclerosis.
Glucose Intolerance
A comparison of the genetic and clinical risk factors for arterial hypertension between indigenous and non-indigenous people of the Shoria Mountain Region.
Association of Methylene Tetrahydrofolate Reductase C677T Genotype With Type 2 Diabetes Mellitus Patients With and Without Renal Complications.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
The prevalence of factor V Leiden, prothrombin G20210A and methylenetetrahydrofolate reductase polymorphism C677T among G6PD deficient individuals from Western Iran.
Glucosephosphate Dehydrogenase Deficiency
The prevalence of factor V Leiden, prothrombin G20210A and methylenetetrahydrofolate reductase polymorphism C677T among G6PD deficient individuals from Western Iran.
glutamate formimidoyltransferase deficiency
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Graft vs Host Disease
Decreased risk of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in patients with the 5,10-methylenetetrahydrofolate reductase 677TT genotype.
Donor methylenetetrahydrofolate reductase genotype is associated with graft-versus-host disease in hematopoietic stem cell transplant patients treated with methotrexate.
Methylenetetrahydrofolate reductase and thymidylate synthase genotypes and risk of acute graft-versus-host disease following hematopoietic cell transplantation for chronic myelogenous leukemia.
The Effect of Folinic Acid on Methylenetetrahydrofolate Reductase Polymorphisms in Methotrexate-Treated Allogeneic Hematopoietic Stem Cell Transplants.
Graves Disease
Association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and susceptibility to Graves' ophthalmopathy.
Association study between methylenetetrahydrofolate reductase gene polymorphisms and Graves' disease.
guanidinoacetate n-methyltransferase deficiency
Targeted cerebrospinal fluid analysis for inborn errors of metabolism on an LC-MS/MS analysis platform.
Gyrate Atrophy
Targeted cerebrospinal fluid analysis for inborn errors of metabolism on an LC-MS/MS analysis platform.
Hamartoma
Are the methylenetetrahydrofolate reductase 1298 and 677 gene polymorphisms related to optic glioma and hamartoma risk in neurofibromatosis type 1 patients?
Hand-Foot Syndrome
Association of C677T and A1298C MTHFR Polymorphisms and Fluoropyrimidine-induced Toxicity in Mestizo Patients With Metastatic Colorectal Cancer.
Evaluation of 5-fluorouracil degradation rate and Pharmacogenetic profiling to predict toxicity following adjuvant Capecitabine.
Polymorphisms of MTHFR and TYMS predict capecitabine-induced hand-foot syndrome in patients with metastatic breast cancer.
Head and Neck Neoplasms
Head and neck cancer susceptibility: a genetic marker in the methylenetetrahydrofolate reductase gene.
Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer.
MTHFR C677T gene polymorphism and head and neck cancer risk: a meta-analysis based on 23 publications.
MTHFR C677T polymorphism interaction with heavy alcohol consumption increases head and neck carcinoma risk.
No association between MTHFR A1298C gene polymorphism and head and neck cancer risk: a meta-analysis based on 9,952 subjects.
Polymorphisms and haplotypes in methylenetetrahydrofolate reductase gene and head and neck squamous cell carcinoma risk.
Headache Disorders, Primary
Genes and primary headaches: discovering new potential therapeutic targets.
Hearing Loss
MTHFR 677T is a strong determinant of the degree of hearing loss among Polish males with postlingual sensorineural hearing impairment.
Prothrombotic gene mutations in patients with sudden sensorineural hearing loss and cardiovascular thrombotic disease.
Hearing Loss, Sensorineural
Association between the methylenetetrahydrofolate reductase gene C677T polymorphism and sudden sensorineural hearing loss: a meta-analysis.
Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with sudden sensorineural hearing loss.
Impact of Methionine Synthase Gene and Methylenetetrahydrofolate Reductase Gene Polymorphisms on the Risk of Sudden Sensorineural Hearing Loss.
Methylenetetrahydrofolate reductase C677T gene mutation as risk factor for sudden sensorineural hearing loss: association with plasma homocysteine, folate and cholesterol concentrations.
MTHFR AND ApoE genetic variants association with sudden sensorineural hearing loss.
Prothrombotic gene mutations in patients with sudden sensorineural hearing loss and cardiovascular thrombotic disease.
Role of Genetic and Acquired Prothrombotic Risk Factors in Genesis of Sudden Sensorineural Hearing Loss.
Sudden sensorineural hearing loss: A vascular cause? Analysis of prothrombotic risk factors in head and neck.
Hearing Loss, Sudden
Methylenetetrahydrofolate reductase gene mutations as risk factors for sudden hearing loss.
Sudden hearing loss and MTHFR 677C>T/1298A>C gene polymorphisms.
Heart Defects, Congenital
A probe directed recombinase amplification assay for detection of MTHFR A1298C polymorphism associated with congenital heart disease.
Are polymorphisms in MTRR A66G and MTHFR C677T genes associated with congenital heart diseases in Iranian population?
Association analysis between MTHFR genetic polymorphisms and the risk of congenital heart diseases in Chinese Han population.
Association analysis of maternal MTHFR gene polymorphisms and the occurrence of congenital heart disease in offspring.
Association between 5, 10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and congenital heart disease: A meta-analysis.
Association Between MTHFR C677T Polymorphism and Congenital Heart Disease.
Association between MTHFR C677T polymorphism and congenital heart disease. A family-based meta-analysis.
Association between MTHFR polymorphisms and congenital heart disease: a meta-analysis based on 9,329 cases and 15,076 controls.
Association of congenital cardiac defects and the C677T methylenetetrahydrofolate reductase polymorphism.
Association of the C677T methylenetetrahydrofolate reductase mutation with congenital heart diseases.
Congenital heart defects, maternal homocysteine, smoking, and the 677 C>T polymorphism in the methylenetetrahydroflate reductase gene: evaluating gene-environment interactions.
Correlation Between Methyltetrahydrofolate Reductase (MTHFR) Polymorphisms and Isolated Patent Ductus Arteriosus in Taiwan.
Evaluation of C677T and A1298C polymorphisms of the MTHFR gene as maternal risk factors for Down syndrome and congenital heart defects.
Evaluation of High Resolution Melting for MTHFR C677T Genotyping in Congenital Heart Disease.
Fission Yeast Methylenetetrahydrofolate Reductase Ensures Mitotic and Meiotic Chromosome Segregation Fidelity.
Genetic polymorphism of methylenetetrahydrofolate reductase as a potential risk factor for congenital heart disease: A meta-analysis in Chinese pediatric population.
Homocysteine concentrations and molecular analysis in patients with congenital heart defects.
Hyperhomocysteinemia and MTHFR polymorphisms in association with orofacial clefts and congenital heart defects: a meta-analysis.
Infant methylenetetrahydrofolate reductase 677TT genotype is a risk factor for congenital heart disease.
Lack of evidence of association between MTHFR C677T polymorphism and congenital heart disease in a TDT study design.
Maternal and offspring MTHFR gene C677T polymorphism as predictors of congenital atrial septal defect and patent ductus arteriosus.
Maternal folate deficiency affects proliferation, but not apoptosis, in embryonic mouse heart.
Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice.
Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation.
Maternal MTHFR C677T polymorphism and congenital heart defect risk in the Chinese Han population: a meta-analysis.
Meta analysis of the association between MTHFR C677T polymorphism and the risk of congenital heart defects.
Meta-Prediction of MTHFR Gene Polymorphism and Air Pollution on the Risks of Congenital Heart Defects Worldwide: A Transgenerational Analysis.
Methylene tetrahydrofolate reductase polymorphisms and homocysteine level in heart defects.
Methylenetetrahydrofolate reductase C677T polymorphism and congenital heart disease: a meta-analysis.
Methylenetetrahydrofolate Reductase C677T: Hypoplastic Left Heart and Thrombosis.
Methylenetetrahydrofolate reductase gene 677CT polymorphism and isolated congenital heart disease in a Mexican population.
MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies.
MTHFR C677T and A1298C gene polymorphisms and their relation to homocysteine level in Egyptian children with congenital heart diseases.
MTHFR C677T and A1298C polymorphisms as a risk factor for congenital heart defects in Down syndrome.
MTHFR C677T Polymorphism and Risk of Congenital Heart Defects: Evidence from 29 Case-Control and TDT Studies.
MTHFR polymorphisms in Puerto Rican children with isolated congenital heart disease and their mothers.
MTHFR promoter hypermethylation may lead to congenital heart defects in Down syndrome.
Non-optimal maturation of the oocyte, maternal MTHFR polymorphisms, periconceptional folate, and decrease of congenital heart defects.
Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect.
Polymorphism 677C?T MTHFR Gene in Mexican Mothers of Children With Complex Congenital Heart Disease.
Risk factors and methylenetetrahydrofolate reductase gene in congenital heart disease.
Study on Environmental Causes and SNPs of MTHFR, MS and CBS Genes Related to Congenital Heart Disease.
Study on Maternal SNPs of MTHFR Gene and HCY Level Related to Congenital Heart Diseases.
The association between c.1333C?>?T genetic polymorphism of MTHFR gene and the risk of congenital heart diseases.
The association between maternal methylenetetrahydrofolate reductase C677T and A1298C polymorphism and birth defects and adverse pregnancy outcomes.
The association of the MTHFR c.1625A>C genetic variant with the risk of congenital heart diseases in the Chinese.
The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot.
The MTHFR 677C->T polymorphism and the risk of congenital heart defects: a literature review and meta-analysis.
The roles of MTRR and MTHFR gene polymorphisms in congenital heart diseases: a meta-analysis.
Two Common MTHFR Gene Polymorphisms (C677T and A1298C) and Fetal Congenital Heart Disease Risk: An Updated Meta-Analysis with Trial Sequential Analysis.
[A case-control study on congenital heart diseases with methylenetetrahydrofolate reductase gene, cystathionine beta-synthase gene, and environmental factors]
[Correlation between offspring congenital heart disease and MTHFR 677C/T polymorphism and general status of pregnant women].
[Correlationship between congenital heart disease and polymorphism of MTHFR gene].
[Study of correlationship between congenital heart disease and 5, 10-methylenetetra hydrofolate reductase gene's polymorphism or folacin intakes]
Heart Diseases
Association of methylenetetrahydrofolate reductase gene C677T polymorphism with polycystic ovary syndrome risk: a systematic review and meta-analysis update.
Association of MTHFR A1298C polymorphism with conotruncal heart disease.
Clinical presentation, etiology, and outcome of stroke in children: A hospital-based study.
Decreased expression of methylene tetrahydrofolate reductase (MTHFR) gene in patients with rheumatoid arthritis.
Family-based investigation of the C677T polymorphism of the methylenetetrahydrofolate reductase gene in ischaemic heart disease.
Increased Resistance to Malaria in Mice with Methylenetetrahydrofolate Reductase (Mthfr) Deficiency Suggests a Mechanism for Selection of the MTHFR 677C>T (c.665C>T) Variant.
Lack of association between methylenetetrahydrofolate reductase (MTHFR) C677T and ischaemic heart disease (IHD): family-based association study in a Spanish population.
MTHFR c.1793G>A polymorphism is associated with congenital cardiac disease in a Chinese population.
MTHFR genetic testing: Controversy and clinical implications.
Prevalence of MTHFR gene polymorphisms (C677T and A1298C) among Tamilians.
Relationship of MTHFR gene polymorphisms with renal and cardiac disease.
Sequence Variation of the Methylene Tetrahydrofolate Reductase Gene (677C>T and 1298?A>C) and Traditional Risk Factors in a South Indian Population.
The dose-response relation between serum homocysteine and cardiovascular disease: implications for treatment and screening.
Heart Failure
Biventricular Thrombi in a Patient With Heart Failure With Severely Reduced Ejection Fraction and Heterozygous Prothrombin 20210G/A and Homozygous Methylenetetrahydrofolate Reductase 677C/T Mutations.
GST M1/T1 and MTHFR polymorphisms as risk factors for hypertension.
Heart Septal Defects, Atrial
Genomics and Epigenomics of Congenital Heart Defects: Expert Review and Lessons Learned in Africa.
Maternal and offspring MTHFR gene C677T polymorphism as predictors of congenital atrial septal defect and patent ductus arteriosus.
Secundum atrial septal defects and methylenetetrahydrofolate reductase C677T polymorphism: A special category of ASDs?
Heart Septal Defects, Ventricular
Analysis of MTHFR and MTRR Gene Polymorphisms in Iranian Ventricular Septal Defect Subjects.
Genomics and Epigenomics of Congenital Heart Defects: Expert Review and Lessons Learned in Africa.
MTHFR c.1793G>A polymorphism is associated with congenital cardiac disease in a Chinese population.
HELLP Syndrome
Genetic aspects of preeclampsia and the HELLP syndrome.
High frequency of methylenetetrahydrofolate reductase 677TT genotype in Hungarian HELLP syndrome patients determined by quantitative real-time PCR.
Hyperhomocysteinaemia: a risk factor for preeclampsia?
Maternal factor V Leiden mutation is associated with HELLP syndrome in Caucasian women.
Methylenetetrahydrofolate reductase polymorphisms in preeclampsia and the HELLP syndrome.
PP004. Study of the methylenetetrahydrofolate reductase and the reduced-folate carrier-1 gene polymorphism in healthy and severe pre-eclamptic patients.
Hematologic Diseases
Decreased risk of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in patients with the 5,10-methylenetetrahydrofolate reductase 677TT genotype.
Role of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies.
Hematologic Neoplasms
Folate restriction and methylenetetrahydrofolate reductase 677T polymorphism decreases adoMet synthesis via folate-dependent remethylation in human-transformed lymphoblasts.
MTHFR gene polymorphisms and methotrexate toxicity in adult patients with hematological malignancies: a meta-analysis.
Pharmacogenetics of methotrexate in pediatric hematological neoplasm treatment: does it need a personalized regimen based on MTHFR polymorphisms?
Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).
Role of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies.
The influence of MTHFR genetic polymorphisms on adverse reactions after methotrexate in patients with hematological malignancies: a meta-analysis.
The relationship between methylenetetrahydrofolate reductase polymorphism and hematological malignancy.
The role of MTHFR and RFC1 polymorphisms on toxicity and outcome of adult patients with hematological malignancies treated with high-dose methotrexate followed by leucovorin rescue.
Thrombosis in children with hematologic malignancies.
[A new method for 5, 10-methylenetetrahydrofolate reductase single nucleotide polymorphisms genotyping used to study susceptibility of hematological malignancy]
[PROVISIONAL] The differential effects of the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) on hematological malignancies among Latinos: a meta-analysis.
Hematuria
Henoch-Schonlein purpura: polymorphisms in thrombophilia genes.
Hemochromatosis
Expanded carrier screening in gamete donors of Venezuela.
Genetic testing costs and compliance with clinical best practices.
Genotyping of single-nucleotide polymorphisms by high-resolution melting of small amplicons.
Nucleotide extension genotyping by high-resolution melting.
Prediction of features of the course of chronic hepatitis C using Bayesian networks.
Hemoglobinuria
Budd-Chiari syndrome in a paroxysmal nocturnal hemoglobinuria patient with coexistence of factor II and MTHFR mutations.
Hemoglobinuria, Paroxysmal
Budd-Chiari syndrome in a paroxysmal nocturnal hemoglobinuria patient with coexistence of factor II and MTHFR mutations.
Hemolytic-Uremic Syndrome
Postoperative Symptomatic Cerebral Infarction in Pediatric Moyamoya Disease: Risk Factors and Clinical Outcome.
The TT genotype of the C677T polymorphism in the methylentetrahydrofolate reductase as a risk factor in thrombotic microangiopathies: results from a pilot study.
Hemophilia A
Clinical variability of haemophilia A and B in Mexican families by factor V Leiden G1691A, prothrombin G20210A and MTHFR C677T/A1298C.
Does the MTHFR 677T allele alter the clinical phenotype in severe haemophilia A?
Effect of Prothrombotic Mutations on Factor Consumption in Children With Hemophilia.
Haemophilia and thrombophilia. What do we learn about combined inheritance of both genetic variations?
Impact of Prothrombotic Risk Factors in a Cohort of Egyptian Hemophilia A Patients.
The Impact of Prothrombotic Mutations on Factor Consumption in Adult Patients With Severe Hemophilia.
Hemorrhagic Stroke
Association of the C677T Polymorphism in the MTHFR Gene with Hemorrhagic Stroke: A Meta-Analysis.
Evaluation of MTHFR C677T polymorphism in ischemic and hemorrhagic stroke patients. A case-control study in a Northern Indian population.
Methylenetetrahydrofolate Reductase Gene Polymorphisms (C677T and A1298C) and Hemorrhagic Stroke in Moroccan Patients.
Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: Dual effect of MTHFR polymorphisms C677T and A1298C.
Prospective study of first stroke in relation to plasma homocysteine and MTHFR 677C>T and 1298A>C genotypes and haplotypes - evidence for an association with hemorrhagic stroke.
Quantitative assessment of the association between MTHFR C677T polymorphism and hemorrhagic stroke risk.
Relationship between methylenetetrahydrofolate reductase (MTHFR) gene (A1298C) polymorphism with the risk of stroke: A systematic review and meta-analysis.
Hemostatic Disorders
[Association of hemostatic disorders in diabetic patients with methylenetetrahydrofolate reductase (C677T) and coagulation factors II (G20210A) and V (G1691A) gene polymorphism].
Hepatic Veno-Occlusive Disease
MTHFR C677T/A1298C genotype: a possible risk factor for liver sinusoidal obstruction syndrome.
TPMT and MTHFR genotype is not associated with altered risk of thioguanine-related sinusoidal obstruction syndrome in pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group.
Hepatitis
Associations between MTHFR Ala222Val polymorphism and risks of hepatitis and hepatitis-related liver cancer: a meta-analysis.
Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics.
Hepatitis B
Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms as risk factors for hepatocellular carcinoma in a Korean population.
PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis.
Hepatitis C
Homocysteine levels and sustained virological response to pegylated-interferon alpha2b plus ribavirin therapy for chronic hepatitis C: a prospective study.
Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and high plasma homocysteine in Chronic Hepatitis C (CHC) infected patients from the Northeast of Brazil.
Methylenetetrahydrofolate reductase C677T polymorphism and liver fibrosis progression in patients with recurrent hepatitis C.
Methylenetetrahydrofolate reductase homozygosis and low-density lipoproteins in patients with genotype 1 chronic hepatitis C.
PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis.
Possible roles of methylenetetrahydrofolate reductase polymorphism and folate status in patients with early hepatitis C virus genotype 4.
Hepatitis C, Chronic
Homocysteine levels and sustained virological response to pegylated-interferon alpha2b plus ribavirin therapy for chronic hepatitis C: a prospective study.
Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients.
Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and high plasma homocysteine in Chronic Hepatitis C (CHC) infected patients from the Northeast of Brazil.
Methylenetetrahydrofolate reductase C677T polymorphism and liver fibrosis progression in patients with recurrent hepatitis C.
Methylenetetrahydrofolate reductase homozygosis and low-density lipoproteins in patients with genotype 1 chronic hepatitis C.
MTHFR rs1801133 Polymorphism Is Associated With Liver Fibrosis Progression in Chronic Hepatitis C: A Retrospective Study.
[Endothelial dysfunction gene polymorphisms and the rate of liver fibrosis in chronic hepatitis C].
[Mathematic Model for Prediction of Liver Fibrosis Progression Rate in Patients with Chronic Hepatitis C Based on Combination of Genomic Markers].
Hepatolenticular Degeneration
Genetic variability in the methylenetetrahydrofolate reductase gene (MTHFR) affects clinical expression of Wilson's Disease.
Hereditary Angioedema Type III
Hereditary angioedema type III, recurrent pregnancy loss and heterozygous MTHFR mutation.
Hereditary Angioedema Types I and II
Management of hereditary angioedema type I and homozygous MTHFR mutation during pregnancy.
Hernia, Umbilical
Folate and vitamin B12-related genes and risk for omphalocele.
Folate-related genes and omphalocele.
Herpes Simplex
Evaluation of etiology and pregnancy outcome in recurrent miscarriage patients.
Hirschsprung Disease
Acute complete splenic infarction in a patient with Hirschsprung's disease and literature review of complete splenic infarction.
Hodgkin Disease
Nutrients and Genetic Variation Involved in One-Carbon Metabolism and Hodgkin Lymphoma Risk: A Population-based Case-Control Study.
Homocystinuria
Acute stroke in relation to homocysteine and methylenetetrahydrofolate reductase gene polymorphisms.
Betaine for treatment of homocystinuria caused by methylenetetrahydrofolate reductase deficiency.
Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.
Characterization of mutations in severe methylenetetrahydrofolate reductase deficiency reveals an FAD-responsive mutation.
Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria.
Clinical presentation, etiology, and outcome of stroke in children: A hospital-based study.
Coexistence of Neurofibromatosis Type-1 and MTHFR C677T Gene Mutation in a Young Stroke Patient: A Case Report.
Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes.
Detection of homozygotes and heterozygotes with methylenetetrahydrofolate reductase deficiency.
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
Folic acid nonresponsive homocystinuria due to methylenetetrahydrofolate reductase deficiency.
Functional characterization of missense mutations in severe methylenetetrahydrofolate reductase deficiency using a human expression system.
Genomic structure and transcript variants of the human methylenetetrahydrofolate reductase gene.
High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.
Homocysteine and the pathogenesis of atherosclerosis.
Homocystinuria associated with decreased methylenetetrahydrofolate reductase activity.
Homocystinuria Due to MTHFR Variant Presenting As Infantile Tremor Syndrome.
Homozygous cystathionine beta-synthase deficiency, combined with factor V Leiden or thermolabile methylenetetrahydrofolate reductase in the risk of venous thrombosis.
Hydrocephalus internus in two patients with 5,10-methylenetetrahydrofolate reductase deficiency.
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Intermediate hyperhomocysteinaemia and compound heterozygosity for the common variant c.677C>T and a MTHFR gene mutation.
Life-threatening methylenetetrahydrofolate reductase (MTHFR) deficiency with extremely early onset: Characterization of two novel mutations in compound heterozygous patients.
Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency.
Methylenetetrahydrofolate reductase deficiency: importance of early diagnosis.
Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.
Molecular and clinical characterisation of homocystinuria in two Austrian families with cystathionine beta-synthase deficiency.
Molecular characterization of five patients with homocystinuria due to severe methylenetetrahydrofolate reductase deficiency.
MTHFR: Addressing Genetic Counseling Dilemmas Using Evidence-Based Literature.
Mutational landscape screening of methylene tetrahydrofolate reductase to predict homocystinuria associated variants: An integrative computational approach.
Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines.
Oxidative stress and apoptosis in homocystinuria patients with genetic remethylation defects.
Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia.
Reversible leukoencephalopathy and cerebral atrophy in Homocystinuria due to MTHFR deficiency: A treatable metabolic disorder.
Sequential multiple retinal vein occlusions and transient ischemic attack in MTHFR polymorphism and protein S deficiency.
Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency.
Severe methylenetetrahydrofolate reductase (MTHFR) deficiency: a case report of nonclassical homocystinuria.
Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus.
Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine ?-synthase-deficient homocystinuria.
The thermolabile variant 677C-->T can further reduce activity when expressed in cis with severe mutations for human methylenetetrahydrofolate reductase.
Treatment of inherited homocystinurias.
[Cystathionine betasynthase and MTHFR deficiencies in adults]
[Effect of folic acid for treatment of homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency]
[Molecular genetics of MTHFR: polymorphisms are not all benign]
Hydatidiform Mole
667C>T and 1298A>C polymorphisms of MTHFR do not predict response to methotrexate in patients with gestational trophoblastic neoplasia.
Hydrocephalus
5,10-Methylenetetrahydrofolate reductase deficiency with progressive polyneuropathy in an infant.
Hydrocephalus internus in two patients with 5,10-methylenetetrahydrofolate reductase deficiency.
Multiloculated hydrocephalus of intrauterine-onset: a case report of an unexpected MTHFR A1298C positive test result.
Hyperalgesia
Investigation of MTHFR C677T Gene Polymorphism, Biochemical and Clinical Parameters in Turkish Migraine Patients: Association with Allodynia and Fatigue.
Hyperargininemia
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
Hypercholesterolemia
A comparison of the genetic and clinical risk factors for arterial hypertension between indigenous and non-indigenous people of the Shoria Mountain Region.
Assessment of genetic risk for myocardial infarction.
Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary risk factors.
Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis.
Individual and Joint Associations of Methylenetetrahydrofolate Reductase C677T Genotype and Plasma Homocysteine With Dyslipidemia in a Chinese Population With Hypertension.
NONICHEMIC CENTRAL RETINAL VEIN OCCLUSION ASSOCIATED WITH HEREDITARY THROMBOPHYLIA.
Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease.
Hyperglycemia
MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients.
No association between MTHFR gene polymorphism and diabetic nephropathy in Japanese type II diabetic patients with proliferative diabetic retinopathy.
Risk factors of cerebral ischemia in infants born to mothers with gestational diabetes.
Hyperglycinemia, Nonketotic
Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.
Hyperhomocysteinemia
5-methyltetrahydrofolate administration is associated with prolonged survival and reduced inflammation in ESRD patients.
A 31 year old woman with essential hypertension grade III and branch retinal vein occlusion with homozygous C677T MTHFR hyperhomocysteinemia and high Lp(a) levels.
A case of vascular parkinsonism associated with hyperhomocysteinemia and methylenetetrahydrofolate reductase gene variant (C677T).
A case-control study investigating the effect of MTHFR C677T variant on performance of elite athletes.
A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations.
A common mutation in the methylenetetrahydrofolate reductase gene (C677T) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V:Q506).
A common mutation in the methylenetetrahydrofolate reductase gene is a determinant of hyperhomocysteinemia in epileptic patients receiving anticonvulsants.
A novel multiplex PCR-RFLP method for simultaneous detection of the MTHFR 677 C > T, eNOS +894 G > T and - eNOS -786 T > C variants among Malaysian Malays.
A possible genetic link between MTHFR genotype and smoking behavior.
A possible synergistic effect of MTHFR C677T polymorphism on homocysteine level variations increased risk for ischemic stroke.
A prospective cohort study of MTHFR C677T gene polymorphism and its influence on the therapeutic effect of homocysteine in stroke patients with hyperhomocysteinemia.
A review on clotting disorders and retinal hemorrhages: Can they mimic abuse?
A study of hyperhomocysteinemia in cerebral venous sinus thrombosis.
A Systematic Review of Parkinson's Disease Pharmacogenomics: Is There Time for Translation into the Clinics?
ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing.
Acute adrenal failure associated with primary antiphospholipid syndrome and homozygosity for MTHFR C677T.
Acute leukoencephalopathy possibly induced by phenytoin intoxication in an adult patient with methylenetetrahydrofolate reductase deficiency.
Acute renal infarction associated with homozygous methylenetetrahydrofolate reductase mutation C677T and IgA beta-2-glycoprotein antibodies.
Acute stroke in relation to homocysteine and methylenetetrahydrofolate reductase gene polymorphisms.
Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring Study Cohort.
Age dependence of the influence of methylenetetrahydrofolate reductase genotype on plasma homocysteine level.
Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.
antiphospholipid antibodies syndrome associated with hyperhomocysteinemia related to MTHFR Gene C677T and A1298C heterozygous mutations in a young man with idiopathic hypoparathyroidism (DiGeorge syndrome).
Association between 5,10-Methylenetetrahydrofolate Reductase C677T Gene Polymorphism and Risk of Ischemic Stroke: A Meta-analysis.
Association between methylenetetrahydrofolate reductase (MTHFR) polymorphism and carotid intima medial thickness progression in post ischaemic stroke patient.
Association between MTHFR 677C-T polymorphism and alcohol dependence according to Lesch and Babor typology.
Association between thrombophilia gene polymorphisms and recurrent pregnancy loss risk in the Iranian population.
Association of congenital cardiac defects and the C677T methylenetetrahydrofolate reductase polymorphism.
Association of Genetic Variants with Hyperhomocysteinemia in Indian Patients with Thrombosis.
Association of methylenetetrahydrofolate reductase (MTHFR 677C>T and 1298A>C) polymorphisms and haplotypes with silent brain infarction and homocysteine levels in a Korean population.
Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women.
Association of Methylenetetrahydrofolate Reductase C677T and Cystathionine β-Synthase Polymorphisms in Cardiovascular Disease in the Algerian Population.
Association of Methylenetetrahydrofolate Reductase C677T Polymorphism with Hyperhomocysteinemia and Deep Vein Thrombosis in the Iranian Population.
Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population.
Association of MTRR 66A>G polymorphism with superoxide dismutase and disease activity in patients with Crohn's disease.
Association of parental hyperhomocysteinemia and C677T Methylene tetrahydrofolate reductase (MTHFR) polymorphism with recurrent pregnancy loss.
Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C667T polymorphism, with bone mineral density in postmenopausal Iranian women: a cross-sectional study.
Association of polymorphism of methylene-tetrahydro-folate-reductase with urinary albumin excretion rate in type 1 diabetes mellitus but not with preeclampsia, retinopathy, and preterm delivery.
Association of serum VLDL level with hyperhomocysteinemia in hypertensive patients: A cross-sectional study.
Association of the methylene-tetrahydrofolate reductase gene rs1801133 C677T variant with serum homocysteine levels, and the severity of coronary artery disease.
Association of Vitamin B12 Deficiency with Homozygosity of the TT MTHFR C677T Genotype, Hyperhomocysteinemia, and Endothelial Cell Dysfunction.
Association study of methylenetetrahydrofolate reductase C677T mutation with cerebral venous thrombosis in an Iranian population.
Association Study of MTHFR Polymorphisms with Nonarteritic Anterior Ischemic Optic Neuropathy in a Spanish Population.
Blood S-adenosylmethionine concentrations and lymphocyte methylenetetrahydrofolate reductase activity in diabetes mellitus and diabetic nephropathy.
C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular disease.
C677T methylenetetrahydrofolate reductase and plasma homocysteine levels among Thai vegans and omnivores.
C677T methylenetetrahydrofolate reductase gene polymorphism as a risk factor involved in venous thromboembolism: a population-based case-control study.
C677T MTHFR Gene Polymorphism is Contributing Factor in Development of Renal Impairment in Young Hypertensive Patients.
C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease.
C677T mutation of the methylenetetrahydrofolate reductase gene among the Korean infants in Seoul city.
C677T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma.
Case-control Study of methylenetetrahydrofolate reductase mutations and hyperhomocysteinemia and risk of stroke.
CBS mutations and MTFHR SNPs causative of hyperhomocysteinemia in Pakistani children.
Celiac sprue, hyperhomocysteinemia, and MTHFR gene variants.
Cerebral Venous Thrombosis and Livedo Reticularis in a Case with MTHFR 677TT Homozygote.
Cerebral Venous Thrombosis with Subarachnoid Hemorrhage: A Case Report.
Characterization of mutations in severe methylenetetrahydrofolate reductase deficiency reveals an FAD-responsive mutation.
Children with stroke: polymorphism of the MTHFR gene, mild hyperhomocysteinemia, and vitamin status.
Clinical Impact of Thrombophilia Screening in Young Adults with Ischemic Stroke.
Clinical utility of folate pathway genetic polymorphisms in the diagnosis of autism spectrum disorders.
Clinical utility of genotyping the 677C>T variant of methylenetetrahydrofolate reductase in humans is decreased in the post-folic acid fortification era.
Coenzyme Q10, Hyperhomocysteinemia and MTHFR C677T Polymorphism in Levodopa-treated Parkinson's Disease Patients.
Coexistence of Neurofibromatosis Type-1 and MTHFR C677T Gene Mutation in a Young Stroke Patient: A Case Report.
Combination of angiotensin-converting enzyme and methylenetetrahydrofolate reductase gene polymorphisms as determinant risk factors for chronic allograft dysfunction.
Common C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of venous thromboembolism: meta-analysis of 31 studies.
Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis.
Common mutation in the methylenetetrahydrofolate reductase gene offers no support for mild hyperhomocysteinemia being a causal risk factor for cardiovascular disease.
Common polymorphisms in methylenetetrahydrofolate reductase (MTHFR): relationships with plasma homocysteine concentrations and cognitive status in elderly northern italian subjects.
Compound heterozygosity for the C677T and A1298C mutations of the MTHFR gene in a case of hyperhomocysteinemia with recurrent deep thrombosis at young age.
Congenital MTHFR deficiency causing early-onset cerebral stroke in a case homozygous for MTHFR thermolabile variant.
Congenital thrombophilia associated to obstetric complications.
Contribution of the cystathionine beta-synthase gene (844ins68) polymorphism to the risk of early-onset venous and arterial occlusive disease and of fasting hyperhomocysteinemia.
Correlation between C677T MTHFR gene polymorphism, plasma homocysteine levels and the incidence of CAD.
Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease.
Correlation of the C677T MTHFR genotype with homocysteine levels in children with sickle cell disease.
Cystathionine ?-synthase and methylenetetrahydrofolate reductase mutations in Mexican individuals with hyperhomocysteinemia.
Differences in the frequency of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene among the Lebanese population.
Differential contribution of MTHFR C677T variant to the risk of diabetic nephropathy in Lebanese and Bahraini Arabs.
Disturbed One-Carbon Metabolism Causing Adverse Reproductive Outcomes in Mice Is Associated with Altered Expression of Apolipoprotein AI and Inflammatory Mediators PPAR?, Interferon-?, and Interleukin-10.
DNA methylation status of the methylenetetrahydrofolate reductase gene promoter in peripheral blood of end-stage renal disease patients.
Early Thrombosis of a Mitral Annuloplasty Ring in a Patient with MTHFR and Factor V Leiden Mutations.
Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients.
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice.
Effect of MTHFR genotypes and hyperhomocysteinemia on patient and graft survival in kidney transplant recipients.
Effect of MTHFR polymorphisms on hyperhomocysteinemia in levodopa-treated Parkinsonian patients.
Effect of Vitamin B(12) and Folate on Homocysteine levels in colorectal cancer.
Effects of MTHFR C677T polymorphism on vitamin D, homocysteine and natural killer cell cytotoxicity in women with recurrent pregnancy losses.
Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine.
Effects of Periconceptional Multivitamin Supplementation on Folate and Homocysteine Levels Depending on Genetic Variants of Methyltetrahydrofolate Reductase in Infertile Japanese Women.
Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study.
Efficacy of Folic Acid in Children With Migraine, Hyperhomocysteinemia and MTHFR Polymorphisms.
Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease.
Evaluation of the relationship between C677T variants of methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy.
Factor V G1691A, apo E4 allele, hyperhomocysteinemia and MTHFR C677T in a young patient with myocardial infarction.
Factor V G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T gene polymorphism in angiographically documented coronary artery disease.
Factor V Leiden, prothrombin 20210A, methylenetetrahydrofolate reductase 677T, and population genetics.
Factor V Leiden, prothrombin 20210G>A, MTHFR 677C>T and 1298A>C, and homocysteinemia in Tunisian blood donors.
Fasting plasma homocysteine levels are increased in young patients with acute myocardial infarction from Western India.
Folate Deficiency and Gene Polymorphisms of MTHFR, MTR and MTRR Elevate the Hyperhomocysteinemia Risk.
Folate status and a new repletion cut-off value in a group of healthy Majorcan women.
Folate, homocysteine levels, methylenetetrahydrofolate reductase (MTHFR) 677C --> T variant, and the risk of myocardial infarction in young women: effect of female hormones on homocysteine levels.
Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study.
Frequency of methylenetetrahydrofolate reductase C677T polymorphism in patients with cardiovascular disease in Eastern Saudi Arabia.
Frequency of the 677 C-->T mutation of the methylenetetrahydrofolate reductase gene among Kuwaiti sickle cell disease patients.
Functional characterization of missense mutations in severe methylenetetrahydrofolate reductase deficiency using a human expression system.
Further evidence that hyperhomocysteinemia and methylenetetrahydrofolate reductase C677T and A1289C polymorphisms are not risk factors for schizophrenia.
G1793A polymorphisms in the methylene-tetrahydrofolate gene: effect of folic acid on homocysteine levels.
Gene polymorphism and coronary risk factors in Indian population.
Genetic and environmental influences on total plasma homocysteine and coronary artery disease (CAD) risk among South Indians.
Genetic and nongenetic factors influencing plasma homocysteine levels in patients with ischemic cerebrovascular disease and in healthy control subjects.
Genetic causes of mild hyperhomocysteinemia in patients with premature occlusive coronary artery diseases.
Genetic determinants of fasting and post-methionine hyperhomocysteinemia in patients with retinal vein occlusion.
Genetic determinants of the homocysteine level.
Genetic effect of MTHFR C677T polymorphism on the structural covariance network and white-matter integrity in Alzheimer's disease.
Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice.
Genetic polymorphism of 5,10-MTHFR reductase gene in offspring of patients with myocardial infarction.
Genetic polymorphism of methylenetetrahydrofolate reductase G1793A, hyperhomocysteinemia, and folate deficiency correlate with ulcerative colitis in central China.
Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) in ethnic populations in Texas; a report of a novel MTHFR polymorphic site, G1793A.
Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR).
Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer.
Genetic variants in the MTHFR are not associated with fatty liver disease.
Genetic variations observed in arterial and venous thromboembolism--relevance for therapy, risk prevention and prognosis.
Genetic variations of MTHFR gene and their association with preterm birth in Korean women.
Genetic, dietary, and other lifestyle determinants of serum homocysteine levels in young adults in Costa Rica.
Genotype and allele frequencies of the polymorphic methylenetetrahydrofolate reductase gene in Turkey.
Genotype and haplotype distributions of MTHFR677C>T and 1298A>C single nucleotide polymorphisms: a meta-analysis.
Glycine and L-arginine treatment causes hyperhomocysteinemia in cerebral creatine transporter deficiency patients.
Haplotypes of the MTHFR gene are associated with an increased risk of breast cancer in a Han Chinese population in Gansu province.
Has enhanced folate status during pregnancy altered natural selection and possibly Autism prevalence? A closer look at a possible link.
Heterozygous methylenetetrahydrofolate reductase 677C-T gene mutation with mild hyperhomocysteinemia associated with intrauterine iliofemoral artery thrombosis.
Heterozygous prothrombin 20210G/A mutation, associated with hyperhomocysteinemia, and homozygous methylenetetrahydrofolate reductase 677C/T mutation, in a patient with portal and mesenteric venous thrombosis.
High prevalence of hyperhomocysteinemia in chronic alcoholism: the importance of the thermolabile form of the enzyme methylenetetrahydrofolate reductase (MTHFR).
High prevalence of hyperhomocysteinemia related to folate deficiency and the 677C-->T mutation of the gene encoding methylenetetrahydrofolate reductase in coastal West Africa.
Homocysteine and atheromatous renal artery stenosis.
Homocysteine and cardiovascular disease: cause or effect?
Homocysteine and cardiovascular disease: interactions between nutrition, genetics and lifestyle.
Homocysteine and carotid intima-media thickness: a critical appraisal of the evidence.
Homocysteine and human reproduction.
Homocysteine and methylenetetrahydrofolate reductase in subjects undergoing coronary angiography.
Homocysteine and MTHFR and VEGF gene polymorphisms: impact on coronary artery disease.
Homocysteine and the MTHFR 677C-->T allele in premature coronary artery disease. Case control and family studies.
Homocysteine excess: delineating the possible mechanism of neurotoxicity and depression.
Homocysteine levels and disease duration independently correlate with coronary artery calcification in patients with systemic lupus erythematosus.
Homocysteine levels and MTHFR polymorphisms in young patients with acute myocardial infarction: a case control study.
Homocysteine levels are associated with MTHFR A1298C polymorphism in Indian population.
Homocysteine Levels in Chronic Gastritis and Other Conditions: Relations to Incident Cardiovascular Disease and Dementia.
Homocysteine metabolism.
Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF-kappaB/iNOS.
Homocysteine serum levels and MTHFR C677T genotype in patients with Parkinson's disease, with and without levodopa therapy.
Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young women.
Homocysteine, endothelial dysfunction, and coronary artery disease: emerging strategy for secondary prevention.
Homocysteine, hypertension and stroke.
Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and the B-vitamins: a facet of nature-nurture interplay.
Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia.
Homocysteine, small-vessel disease, and atherosclerosis: an MRI study of 825 stroke patients.
Homocysteine, vitamin B status and MTHFR polymorphisms in Italian infertile women.
Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency.
Homocysteinemia is inversely correlated with platelet count and directly correlated with sE- and sP-selectin levels in females homozygous for C677T methylenetetrahydrofolate reductase.
Homozygous C677T mutation in the MTHFR gene as an independent risk factor for multiple small-artery occlusions.
Homozygous C677T mutation of the 5,10 methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in Italian patients with a history of early-onset ischemic stroke.
Homozygous VN (677C to T) and d/D (2756G to A) variants in the methylenetetrahydrofolate and methionine synthase genes in a case of hyperhomocysteinemia with stroke at young age.
Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia.
Hyperbaric oxygen therapy in branch retinal artery occlusion in a 15-year-old boy with methylenetetrahydrofolate reductase mutation.
Hypercoagulable state and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with beta-thalassemia major in Kuwait.
Hypercoagulable thrombophilic defects and hyperhomocysteinemia in patients with recurrent pregnancy loss.
Hyperhomocysteinemia and C677T MTHFR Genotype in Patients With Retinal Vein Thrombosis.
Hyperhomocysteinemia and homozygous MTHFR 677C>T mutation finding in an Alzheimer's disease case with metabolic syndrome diagnosis.
HYPERHOMOCYSTEINEMIA AND ITS TREATMENT IN PATIENTS WITH PARKINSON'S DISEASE.
Hyperhomocysteinemia and methylenetetrahydrofolate reductase 677C-->T and 1298A-->C mutations in patients with inflammatory bowel disease.
Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase C677T Polymorphism in Cerebral Veno-sinus Thrombosis.
Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in a patient with coronary artery disease and repetitive miscarriages.
Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in cervical artery dissection: a meta-analysis.
Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in patients with Parkinson's disease.
Hyperhomocysteinemia and MTHFR C677T and A1298C polymorphisms are associated with chronic allograft nephropathy in renal transplant recipients.
Hyperhomocysteinemia and MTHFR C677T homozygosity in a vegetarian male with sinovenous thrombosis of the brain.
Hyperhomocysteinemia and MTHFR C677T polymorphism in patients with portal vein thrombosis complicating liver cirrhosis.
Hyperhomocysteinemia and MTHFR polymorphisms as antenatal risk factors of white matter abnormalities in two cohorts of late preterm and full term newborns.
Hyperhomocysteinemia and MTHFR polymorphisms in association with orofacial clefts and congenital heart defects: a meta-analysis.
Hyperhomocysteinemia and of Methylenetetrahydrofolate Reductase (C677T) Genetic Polymorphism in Patients with Deep Vein Thrombosis.
Hyperhomocysteinemia and polymorphisms of the methylenetetrahydrofolate gene in hemodialysis and peritoneal dialysis patients.
Hyperhomocysteinemia and prevalence of polymorphisms of homocysteine metabolism-related enzymes in patients with inflammatory bowel disease.
Hyperhomocysteinemia and the compound heterozygous state for methylene tetrahydrofolate reductase are independent risk factors for deep vein thrombosis among South Indians.
Hyperhomocysteinemia and the methylenetetrahydrofolate reductase 677C-T mutation in patients under 50 years of age affected by central retinal vein occlusion.
Hyperhomocysteinemia and the MTHFR C677T mutation in Budd-Chiari syndrome.
Hyperhomocysteinemia and the MTHFR C677T mutation in central retinal vein occlusion.
Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients.
Hyperhomocysteinemia and thrombosis: an overview.
Hyperhomocysteinemia as a risk factor for venous thrombosis.
Hyperhomocysteinemia as an independent risk factor for silent brain infarction.
Hyperhomocysteinemia but not MTHFR genotype is associated with young-onset essential hypertension.
Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS)
Hyperhomocysteinemia in central retinal vein occlusion in young adults.
Hyperhomocysteinemia in high-aged subjects: relation of B-vitamins, folic acid, renal function and the methylenetetrahydrofolate reductase mutation.
Hyperhomocysteinemia in men with a reproductive history of fetal neural tube defects: Three case reports and literature review.
Hyperhomocysteinemia increases the risk of venous thrombosis independent of the C677T mutation of the methylenetetrahydrofolate reductase gene in selected Brazilian patients.
Hyperhomocysteinemia is a risk factor of recurrent coronary event in young patients irrespective to the MTHFR C677T polymorphism.
Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency.
Hyperhomocysteinemia is Associated with Inflammation, Bone Resorption, Vitamin B12 and Folate Deficiency and MTHFR C677T Polymorphism in Postmenopausal Women with Decreased Bone Mineral Density.
Hyperhomocysteinemia, antithrombin consumption, and early venous graft closure in surgical coronary revascularization.
Hyperhomocysteinemia, C677T MTHFR polymorphism and ischemic stroke in Tunisian patients.
Hyperhomocysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient.
Hyperhomocysteinemia, intima-media thickness and C677T MTHFR gene polymorphism: A correlation study in patients with cognitive impairment.
Hyperhomocysteinemia, low folate and vitamin B12 concentrations, and methylene tetrahydrofolate reductase mutation in cerebral venous thrombosis.
Hyperhomocysteinemia, low folate status, homozygous C677T mutation of the methylene tetrahydrofolate reductase and renal arterial thrombosis.
Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: a Dutch population based case-control study.
Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism, and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls.
Hyperhomocysteinemia, MTHFR 677C-->T polymorphism, and stroke.
Hyperhomocysteinemia, MTHFR C677T genotype and low folate levels: a risk combination for acute coronary disease in a Portuguese population.
Hyperhomocysteinemia, MTHFR, and risk of vascular disease.
Hyperhomocysteinemia: a trigger for complement-mediated TMA?
Hyperhomocysteinemia: an additional cardiovascular risk factor.
Hyperhomocysteinemia: clinical and therapeutical involvement in venous thrombosis.
Hypertrophy of IMC of carotid artery in Parkinson's disease is associated with L-DOPA, homocysteine, and MTHFR genotype.
Impact of Genetic Polymorphism of methylenetetrahydrofolate reductase C677T on Development of Hyperhomocysteinemia and Related Oxidative Changes in Egyptian ?-Thalassemia Major Patients.
Impact of MTHFR (C677T) gene polymorphism on antiepileptic drug monotherapy in North Indian epileptic population.
Increased Factor V Leiden frequency is associated with venous thrombotic events among young Brazilian patients.
Influence of 5,10-methylenetetrahydrofolate reductase gene polymorphism on plasma homocysteine concentration in patients with end-stage renal disease.
Influence of combined methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase enhancer region (TSER) polymorphisms to plasma homocysteine levels in Korean patients with recurrent spontaneous abortion.
Inherited and Acquired Thrombophilia in Adults with Retinal Vascular Occlusion: A Systematic Review and Meta-Analysis.
Inherited thrombophilias in pregnant patients: detection and treatment paradigm.
Insufficient S-sulfhydration of Methylenetetrahydrofolate Reductase Contribute to the Progress of Hyperhomocysteinemia.
Interaction between hyperhomocysteinemia and inherited thrombophilic factors in venous thromboembolism.
Interactions of Methylenetetrahydrofolate Reductase Gene Polymorphisms, Folate, and Homocysteine on Blood Pressure in a Chinese Hypertensive Population.
Intermediate and severe hyperhomocysteinemia with thrombosis: a study of genetic determinants.
Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylenetetrahydrofolate reductase mutations.
Interplay between methylenetetrahydrofolate reductase gene polymorphism 677C-->T and serum folate levels in determining hyperhomocysteinemia in heart transplant recipients.
Investigation of methylenetetrahydrofolate reductase C677T and factor V Leiden mutation as a genetic marker for retinal vein occlusion.
Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients.
Is hyperhomocysteinemia a causal factor for heart failure? The impact of the functional variants of MTHFR and PON1 on ischemic and non-ischemic etiology.
Is there an association between the development of metabolic syndrome in PCOS patients and the C677T MTHFR gene polymorphism?
Ischemic stroke subtypes and thrombophilia in young and elderly Brazilian stroke patients admitted to a rehabilitation hospital.
Lack of association between genetic polymorphisms in enzymes associated with folate metabolism and unexplained reduced sperm counts.
Lack of association of methylenetetrahydrofolate reductase 677C>T mutation with coronary artery disease in a Pakistani population.
Life-threatening methylenetetrahydrofolate reductase (MTHFR) deficiency with extremely early onset: Characterization of two novel mutations in compound heterozygous patients.
Livedoid vasculopathy and hypercoagulability in a patient with primary Sjögren's syndrome.
Livedoid vasculopathy associated with combined prothrombin G20210A and factor V (Leiden) heterozygosity and MTHFR C677T homozygosity.
Low frequency of mutated methylenetetrahydrofolate reductase 677C-->T and 1298A-->C genetics single nucleotide polymorphisms (SNPs) in Sub-Saharan populations.
Manifestations of neurological symptoms and thromboembolism in adults with MTHFR-deficiency.
Maternal cerebral venous thrombosis, uncommon but serious disorder, pathologic predictors and contribution of prothrombotic abnormalities.
Medical cost savings in Sakado City and worldwide achieved by preventing disease by folic acid fortification.
MEK Inhibitor-Associated Central Retinal Vein Occlusion Associated with Hyperhomocysteinemia and MTHFR Variants.
Mesenteric venous thrombosis with bowel infarction and hyperhomocysteinemia due to homozygous methylenetetrahydrofolate reductase C677T genotype.
Meta-Prediction of MTHFR Gene Polymorphism Mutations and Associated Risk for Colorectal Cancer.
Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants.
Methylenetetrahydrofolate reductase (C677T and A1298C) polymorphisms, hyperhomocysteinemia, and ischemic stroke in Tunisian patients.
Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid.
Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and high plasma homocysteine in Chronic Hepatitis C (CHC) infected patients from the Northeast of Brazil.
Methylenetetrahydrofolate reductase 677 C-->T mutation and coronary heart disease risk in UK Indian Asians.
Methylenetetrahydrofolate reductase C677T and A1298C polymorphism and changes in homocysteine concentrations in women with idiopathic recurrent pregnancy losses.
Methylenetetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia in Budd-Chiari syndrome and portal vein thrombosis: A systematic review and meta-analysis of observational studies.
Methylenetetrahydrofolate reductase C677T genotype and venous thromboembolic disease.
Methylenetetrahydrofolate reductase C677T mutation and risk of retinal vein thrombosis.
Methylenetetrahydrofolate reductase C677T polymorphism, hypertension and risk of stroke: a prospective, nested case-control study.
Methylenetetrahydrofolate reductase C677T variant and hyperhomocysteinemia in subarachnoid hemorrhage patients from India.
Methylenetetrahydrofolate Reductase Deficiency: A Case Report.
Methylenetetrahydrofolate reductase gene and coronary artery disease.
Methylenetetrahydrofolate Reductase Gene C677T Polymorphism-Dietary Pattern Interaction on Hyperhomocysteinemia in a Chinese Population: A Cross-Sectional Study.
Methylenetetrahydrofolate reductase gene mutation and hyperhomocysteinemia as a risk factor for coronary heart disease in the Indian population.
Methylenetetrahydrofolate reductase gene polymorphism and childhood stroke.
Methylenetetrahydrofolate Reductase Gene Polymorphism and Serum Homocysteine Levels in Nonalcoholic Fatty Liver Disease.
Methylenetetrahydrofolate reductase gene polymorphism, homocysteine and risk of macroangiopathy in Type 2 diabetes mellitus.
Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinemia and occlusive retinal vascular disease in type 2 diabetic and non-diabetic subjects.
Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinemia, and cardiovascular diseases in chronic hemodialysis patients.
Methylenetetrahydrofolate reductase gene polymorphisms in 13 Chinese ethnic populations.
Methylenetetrahydrofolate reductase gene polymorphisms in patients with nonalcoholic steatohepatitis (NASH).
Methylenetetrahydrofolate Reductase Gene-specific Methylation and Recurrent Miscarriages: A Case- Control Study from North India.
Methylenetetrahydrofolate reductase genetic polymorphisms in patients with cataract.
Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma.
Methylenetetrahydrofolate reductase genotypes and early-onset coronary artery disease.
Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study.
Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Recurrent Pregnancy Loss: a Case-Control Study.
Methylenetetrahydrofolate reductase TT genotype as a predictor of cardiovascular risk in hypertensive adolescents.
Methyltetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy.
Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.
Microarray analysis of brain RNA in mice with methylenetetrahydrofolate reductase deficiency and hyperhomocysteinemia.
Mild hyperhomocysteinemia and MTHFR C677T do not increase the risk for venous thrombosis in a Spanish population.
Mild hyperhomocysteinemia and the common C677T polymorphism of methylene tetrahydrofolate reductase gene are not associated with the metabolic syndrome in Type 2 diabetes.
Mild hyperhomocysteinemia, C677T polymorphism on methylenetetrahydrofolate reductase gene and the risk of macroangiopathy in type 2 diabetes: a prospective study.
Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.
Morton's foot and pyridoxal 5'-phosphate deficiency: genetically linked traits.
MR and proton MR spectroscopy of the brain in hyperhomocysteinemia caused by methylenetetrahydrofolate reductase deficiency.
MTHFR A1298C and C677T Polymorphisms Are Associated with Increased Risk of Venous Thromboembolism: A Retrospective Chart Review Study.
MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies.
MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients.
MTHFR C677T mutation in central retinal vein occlusion: a case-control study in Chinese population.
MTHFR C677T polymorphism is associated with hyperlipidemia in women with polycystic ovary syndrome.
MTHFR C677T polymorphism, folate, vitamin B12 and homocysteine in recurrent pregnancy losses: a case control study among north Indian women.
MTHFR C677T polymorphism, folic acid and hyperhomocysteinemia in levodopa treated patients with Parkinson's disease.
MTHFR C677T predisposes to POAG but not to PACG in a North Indian population: a case control study.
MTHFR C677T, MTHFR A1298C, and OPG A163G polymorphisms in Mexican patients with rheumatoid arthritis and osteoporosis.
MTHFR Gene Polymorphisms and Cardiovascular Risk Factors, Clinical-Imagistic Features and Outcome in Cerebral Venous Sinus Thrombosis.
MTHFR homozygous mutation and additional risk factors for cerebral infarction in a large Italian family.
MTHFR polymorphism and risk of periprocedural myocardial infarction after coronary stenting.
MTHFR: Addressing Genetic Counseling Dilemmas Using Evidence-Based Literature.
Multidisciplinary approach and anesthetic management of a surgical cancer patient with methylene tetrahydrofolate reductase deficiency: a case report and review of the literature.
Multifactorial Painful Leg Ulcers Due to Hyperhomocysteinemia, Plasminogen Activator Inhibitor-1 4G/5G Heterozygote Gene Mutation, and Beta Thalassemia Minor: A Case Report.
Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients.
Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia.
Mutation Update and Review of Severe Methylenetetrahydrofolate Reductase Deficiency.
Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice.
Mutations in MTHFR and POLG impaired activity of the mitochondrial respiratory chain in 46-year-old twins with spastic paraparesis.
Mutations in the gene for methylenetetrahydrofolate reductase, homocysteine levels, and vitamin status in women with a history of preeclampsia.
Mutations of the MTHFR gene (428C>T and [458G>T+459C>T]) markedly decrease MTHFR enzyme activity.
Myocardial infarction and venous thrombosis in a 42-year old woman with heterozygous methylenetetrahydrofolate reductase (MTHRF) gene mutation, hyperhomocysteinemia, and protein C deficiency.
Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolate reductase gene polymorphism.
Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations.
No association between MTHFR gene polymorphism and diabetic nephropathy in Japanese type II diabetic patients with proliferative diabetic retinopathy.
No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease.
No association of C677T methylenetetrahydrofolate reductase and an endothelial nitric oxide synthase polymorphism with recurrent pregnancy loss.
No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese.
No interaction between factor V Leiden and hyperhomocysteinemia or MTHFR 677TT genotype in venous thrombosis. Results of a meta-analysis of published studies and a large case-only study.
Non-alcoholic fatty liver disease (NAFLD) and MTHFR 1298A > C gene polymorphism.
Novel insights into the development of portal vein thrombosis in cirrhosis patients.
Nutri-epigenetics ameliorates blood-brain barrier damage and neurodegeneration in hyperhomocysteinemia: role of folic acid.
Nutrigenetic impact of daily folate intake on plasma homocysteine and folate levels in patients with different methylenetetrahydrofolate reductase genotypes.
Pathophysiological consequences of homocysteine excess.
Pediatric stroke and methylenetetrahydrofolate reductase polymorphisms: an examination of C677T and A1298C mutations.
Phenotypic variability of cardiovascular manifestations in Marfan Syndrome. Possible role of hyperhomocysteinemia and C677T MTHFR gene polymorphism.
Plasma homocysteine and the methylenetetrahydrofolate reductase C677T gene variant: lack of association with schizophrenia.
Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain.
Plasma homocysteine concentration in children with chronic renal failure.
Plasma homocysteine levels & 677C-->T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity.
Plasma homocysteine levels related to interactions between folate status and methylenetetrahydrofolate reductase: a study in 52 healthy subjects.
Plasma homocysteine levels, methylene tetrahydrofolate reductase A1298C gene polymorphism and risk of retinal vein thrombosis.
Plasma homocysteine, methylenetetrahydrofolate reductase genotypes, and age at onset of symptoms of myocardial ischemia.
Plasma homocysteine, methylenetetrahydrofolate reductase mutation and carotid damage in elderly healthy women.
Plasma hyperhomocysteinemia, MTHFR polymorphism and thromboembolic disease: an example of gene-nutrition interactions in chronic disease.
Plasma Serotonin is Elevated in Adult Patients with Sudden Sensorineural Hearing Loss.
Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis.
Plasma total homocysteine levels in children with type 1 diabetes: relationship with vitamin status, methylene tetrahydrofolate reductase genotype, disease parameters and coronary risk factors.
Plasminogen activator inhibitor-1, factor V, factor II and methylenetetrahydrofolate reductase polymorphisms in women with recurrent miscarriage.
Polymorphism in methylenetetrahydrofolate reductase gene: its impact on plasma homocysteine levels and carotid atherosclerosis in ESRD patients receiving hemodialysis.
Polymorphism of MTHFR C677T, serum vitamin levels and cognition in subjects with hyperhomocysteinemia in China.
Polymorphism of the methylenetetrahydrofolate reductase gene association with homocysteine and ischemic stroke in type 2 diabetes.
Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts.
Polymorphisms in the CBS gene and homocysteine, folate and vitamin B12 levels: association with polymorphisms in the MTHFR and MTRR genes in Brazilian children.
Polymorphisms in the methylenetetrahydrofolate reductase and methionine synthase reductase genes and homocysteine levels in Brazilian children.
Polymorphisms of methylenetetrahydrofolate reductase gene as the genetic predispositions of coronary artery diseases in eastern India.
POSITIVE EFFECT OF BETAINE-ARGININE SUPPLEMENT ON IMPROVED HYPERHOMOCYSTEINEMIA TREATMENT IN MARRIED COUPLES WITH REPRODUCTIVE DISORDERS.
Posterior cerebral artery occlusion after Mycoplasma pneumoniae infection associated with genetic defect of MTHFR C677T.
Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension.
Prediction of ischemic stroke in young Indians: is thrombophilia profiling a way out?
Premature arterial and venous events in three families. Effect of folate levels and MTHFR mutation mediated by family/generation and homocysteine levels.
Prevalence of hyperhomocysteinemia and the MTHFR C677T polymorphism in patients with arterial and venous thrombosis from North Western Russia.
Prevalence of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Taiwanese patients with Type 2 diabetic mellitus.
Prevalence of methylenetetrahydrofolate reductase gene polymorphisms (C677T, and A1298C) among Saudi children receiving dental treatment.
Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects.
Recurrent small-artery disease in hyperhomocysteinemia: widowers' stroke syndrome?
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.
Relation of a common methylenetetrahydrofolate reductase mutation and plasma homocysteine with intimal hyperplasia after coronary stenting.
Relationship between thiolactonase activity and hyperhomocysteinemia according to MTHFR gene polymorphism in Tunisian Behçet's disease patients.
Relationship of MTHFR gene polymorphisms with renal and cardiac disease.
Renal Insufficiency in Non-Diabetic Subjects: Relationship of MTHFR C677t Gene Polymorphism and Left Ventricular Hypertrophy.
Retinal ganglion cell loss and mild vasculopathy in methylene tetrahydrofolate reductase (Mthfr) deficient mice: a model of mild hyperhomocysteinemia.
Retinal vein occlusion, homocysteine, and methylene tetrahydrofolate reductase genotype.
Retinal vein occlusion: a form of venous thrombosis or a complication of atherosclerosis? A meta-analysis of thrombophilic factors.
Risk of recurrent venous thrombosis in patients with G20210A mutation in the prothrombin gene or factor V Leiden mutation.
Risk of Venous Thrombosis in Carriers of a Common Mutation in the Homocysteine Regulatory Enzyme Methylenetetrahydrofolate Reductase.
Risk-factor profile in severe, generalized, obliterating vascular disease.
Role of a common mutation in the homocysteine regulatory enzyme methylenetetrahydrofolate reductase in ischemic stroke.
Role of Genetic and Acquired Prothrombotic Risk Factors in Genesis of Sudden Sensorineural Hearing Loss.
Role of genetic changes in the progression of cardiovascular diseases.
Role of Hyperhomocysteinemia and Methylene Tetrahydrofolate Reductase C677T Polymorphism in Idiopathic Portal Vein Thrombosis.
Role of MTHFR C677T polymorphism in ischemic stroke.
Role of thrombotic vascular risk factors in inflammatory bowel disease.
Screening for C677T and A1298C MTHFR polymorphisms in patients with epilepsy and risk of hyperhomocysteinemia.
Segmental renal artery thrombosis secondary to methylene tetrahydrofolate reductase mutation: an unusual presentation.
Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR.
Sex-specific effect of the thermolabile C677T mutation in the methylenetetrahydrofolate reductase gene on angiographically assessed coronary artery disease in Brazilians.
Single inherited thrombophilias and adverse pregnancy outcomes.
Single nucleotide polymorphisms in homocysteine metabolism pathway genes: association of CHDH A119C and MTHFR C677T with hyperhomocysteinemia.
Socio-economic disparities in preterm birth: causal pathways and mechanisms.
Splenic thrombosis in three patients with moderate hyperhomocysteinemia, low folate and the C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene.
Study on homocysteine levels and methylenetetrahydrofolate reductase gene variant (C677T) in a population of Buenos Aires city.
Study on Maternal SNPs of MTHFR Gene and HCY Level Related to Congenital Heart Diseases.
Sudden sensorineural hearing loss: A vascular cause? Analysis of prothrombotic risk factors in head and neck.
Systemic risk factors correlated with hyperhomocysteinemia for specific MTHFR C677T genotypes and sex in the Chinese population.
The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine.
The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine.
The 894G > T (Glu298Asp) Variant in the Endothelial NOS Gene and MTHFR Polymorphisms Influence Homocysteine Levels in Patients with Cognitive Decline.
The active site of oxidative phosphorylation and the origin of hyperhomocysteinemia in aging and dementia.
The association of the MTHFR C677T polymorphism with inflammatory bowel diseases in the Israeli Jewish population: An example of genetic heterogeneity.
The C677T mutation in methylenetetrahydrofolate reductase gene, plasma homocysteine concentration and the risk of coronary artery disease.
The C677T mutation in the methylenetetrahydrofolate reductase gene contributes to hyperhomocysteinemia in patients taking anticonvulsants.
The C677T mutation in the methylenetetrahydrofolate reductase gene predisposes to hyperhomocysteinemia in children with familial hypercholesterolemia treated with cholestyramine.
The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor.
The C677T thermolabile variant of methylene tetrahydrofolate reductase on homocysteine, folate and vitamin B12 in a hemodialysis center.
The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are associated with hyperhomocysteinemia and cardiovascular disease in hemodialysis patients.
The communal relation of MTHFR, MTR, ACE gene polymorphisms and hyperhomocysteinemia as conceivable risk of coronary artery disease.
The effect of methylenetetrahydrofolate reductase C677T common variant on hypertensive risk is not solely explained by increased plasma homocysteine values.
The effect of polymorphisms of MTHER gene and vitamin B on hyperhomocysteinemia.
The frequency of Raynaud’s phenomenon in patients with methylenetetrahydrofolate reductase gene mutation and hyperhomocysteinemia
The graded effect of hyperhomocysteinemia on the severity and extent of coronary atherosclerosis.
The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine.
The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations.
The methylenetetrahydrofolate reductase (MTHFR) 677C-->T mutation and cardiovascular risk--A case of ischemic stroke and acute myocardial infarction.
The methylenetetrahydrofolate reductase C677T gene mutation is associated with hyperhomocysteinemia, cardiovascular disease and plasma B-type natriuretic peptide levels in Korea.
The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study.
The methylenetetrahydrofolate reductase TT677 genotype is associated with venous thrombosis independently of the coexistence of the FV Leiden and the prothrombin A20210 mutation.
The MTHFR 677 C/T polymorphism influences plasma levels of adhesion molecules and nitric oxide.
The MTHFR C677T polymorphism modifies age at onset in Parkinson's disease.
The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease.
The relation between erythrocyte volume and folate levels is influenced by a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T).
The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene.
The relationship of the methylenetetrahydrofolate reductase C677T gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy.
The role of hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with retinal artery occlusion.
The role of methylenetetrahydrofolate reductase C677T polymorphism on the peripheral blood natural killer cell proportion in women with unexplained recurrent miscarriages.
The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events.
The roles of methylenetetrahydrofolate reductase 677C>T and 1298A>C polymorphisms in moyamoya disease patients.
The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia.
The thermolabile variant 677C-->T can further reduce activity when expressed in cis with severe mutations for human methylenetetrahydrofolate reductase.
The thrombophilic network of autoantibodies in celiac disease.
Thromboembolic tendency (TE) in IBD (Inflammatory bowel disease) patients.
Thrombophilia and pregnancy.
Thrombophilia in hemodialysis patients: Transfer to peritoneal dialysis is life saving.
Thrombophilias and pregnancy complications: a case-control study.
Thrombophilias and recurrent pregnancy loss.
Thrombophilias as risk factors for disorders of pregnancy and fetal damage.
Thrombophilic risk factors in patients with severe carotid atherosclerosis.
Total homocysteine, folate, and cobalamin, and their relation to genetic polymorphisms, lifestyle and body mass index in healthy children and adolescents.
Treatment of Erectile Dysfunction Due to C677T Mutation of the MTHFR Gene with Vitamin B6 and Folic acid in Patients Non Responders to PDE5i.
Two siblings with a homozygous MTHFR C677T (G80A-RFC1) mutation and stroke.
Unique holoenzyme dimers of the tetrameric enzyme Escherichia coli methylenetetrahydrofolate reductase: characterization of structural features associated with modulation of the enzyme's function.
Vascular and cellular stress in inflammatory bowel disease: revisiting the role of homocysteine.
Venous thromboembolism associated with hyperhomocysteinemia, homozygosity for the methylenetetrahydrofolate reductase 677C>T gene variant, and secondary polycythemia.
Wandering spleen: 'presentation in adolescent with high thrombotic risk'
[A clinical study of hyperhomocysteinemia in rheumatological diseases.]
[A hyperhomocysteinemia study in a population with a familial factor for acute myocardial infarct and sudden cardiac death at a young age]
[Acute cerebral sinus-thrombosis due to polyangiitis overlap syndrome with granulomatosis with polyangiitis (Wegener's granulomatosis) and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)].
[Association of hyperhomocysteinemia with liver steatosis in patients with chronic hepatitis C].
[C677T genetic polymorphism of methylenetetrahydrofolate reductase in premature coronary heart disease]
[Cerebral vascular complication of hyperhomocysteinemia. Controlling thromboembolic complications with folates]
[Effect of hyperhomocysteinemia and methylenetetrahydrofolate reductase 677C --> T mutation in venous thromboembolism risk of young adults]
[Factors determining hyperhomocysteinemia in the chronic phase of strokes]
[Features of allele polymorphism of genes involved in homocysteine and folate metabolism in patients with atherosclerosis of the lower extremity arteries]
[Homocysteine, 5,10-methylenetetrahydrofolate reductase and deep venous thrombosis. Survey of 120 patients in internal medicine]
[Homocysteine--a risk factor for atherosclerosis]
[Homocysteinemia and its relationship with the methylentetrahydrofolate reductase polymorphism in various ethnic groups from western Venezuela]
[Hyperhomocysteinemia and C677T mutation of methylenetetrahydrofolate reductase]
[Hyperhomocysteinemia and pregnancy complications]
[Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease?. 1. Basic data]
[Hyperhomocysteinemia: associated obstetric diabetes and fetal malformations]
[Levels of homocysteine and polymorphisms of homocysteine metabolism-related enzymes in patients with type 2 diabetes mellitus and coronary heart disease]
[Lowering high levels of fasting total homocysteine with folic acid and vitamins B in patients with venous thromboembolism: relationship between response and the C677T methylenetetrahydrofolate reductase (MTHRF) genotype]
[Methylenetetrahydrofolate reductase deficiency-induced schizophrenia in a school-age boy].
[Methylenetetrahydrofolate reductase gene polymorphism and plasma homocysteine levels in hemodialysing patients]
[Methylenetetrahydrofolate reductase polymorphism C677T in patients with consolidated fractures and pseudarthrosis of long bones: relationship with homocystein and inflammatory mediators].
[Molecular genetics of MTHFR: polymorphisms are not all benign]
[Portal and mesenteric vein thrombosis associated with hyperhomocysteinemia and pernicious anemia in a patient heterozygous for the MTHFR C677T mutation.]
[Prevalence of methylenetetrahydrofolate reductase C677T mutation among patients with acute ischemic cerebrovascular disease in Aragon]
[Promoters of genes MTHFR from patients with hyperhomocysteinemia and PTEN from patients with malignant and benign endometrial and ovarian tumors]
[Some aspects of homocysteine metabolism in hemodialysis patients]
[THE DIFFERENTIATED APPROACH TO PREVENTION OF NEURAL TUBE DEFECTS IN CHILDREN].
[The genetic polymorphism of MTHFR gene in schizophrenia]
[The relationship between the plasma homocysteine level and the polymorphism of MTHFR gene C667T in liver cirrhosis]
[The role of homocysteine and methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase polymorphisms in the development of cardiovascular diseases and hypertension].
[Thrombophilia, preeclampsia and other pregnancy complications]
Hyperinsulinism
Effects of a high-fat-sucrose diet on enzymes in homocysteine metabolism in the rat.
Hyperlipidemias
Association of MTHFR genetic polymorphisms with venous thromboembolism in Uyghur population in Xinjiang, China.
Effect of simvastatin on plasma homocysteine levels and its modification by MTHFR C677T polymorphism in Chinese patients with primary hyperlipidemia.
MTHFR C677T polymorphism is associated with hyperlipidemia in women with polycystic ovary syndrome.
Plasma homocysteine and gene polymorphisms associated with the risk of hyperlipidemia in northern Chinese subjects.
[Association of C677T gene polymorphisms of methylenetetrahydrofolate reductase and plasma homocysteine level with hyperlipidemia].
Hyperlipoproteinemia Type II
Association of C677T polymorphism in MTHFR gene, high homocysteine and low HDL cholesterol plasma values in heterozygous familial hypercholesterolemia.
Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia.
Serum homocysteine, methylenetetrahydrofolate reductase gene polymorphism and cardiovascular disease in heterozygous familial hypercholesterolemia.
The C677T mutation in the methylenetetrahydrofolate reductase gene predisposes to hyperhomocysteinemia in children with familial hypercholesterolemia treated with cholestyramine.
Hyperlipoproteinemias
The association of MTHFR C677T gene variants and lipid profiles or body mass index in patients with diabetic and nondiabetic coronary heart disease.
Hyperparathyroidism
Renal Insufficiency in Non-Diabetic Subjects: Relationship of MTHFR C677t Gene Polymorphism and Left Ventricular Hypertrophy.
Hypersensitivity
The association between mother and child MTHFR C677T polymorphisms, dietary folate intake and childhood atopy in a population-based, longitudinal birth cohort.
[A case of acute lymphoblastic leukemia of MTHFR C677T gene positive with methotrexate hypersensitivity was successfully rescued by hemodialysis].
Hypertension
5,10-Methylenetetrahydrofolate reductase polymorphism and early organ damage in primary hypertension.
A case of vascular parkinsonism associated with hyperhomocysteinemia and methylenetetrahydrofolate reductase gene variant (C677T).
A common mutation in methylenetetrahydrofolate reductase gene among the Japanese population.
A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension.
A prospective cohort study of MTHFR C677T gene polymorphism and its influence on the therapeutic effect of homocysteine in stroke patients with hyperhomocysteinemia.
Addressing optimal folate and related B-vitamin status through the lifecycle: health impacts and challenges.
Age and hypertension related changes in genotypes of MTHFR 677C>T, 1298A>C and PON1 -108C>T SNPs in men with coronary artery disease (CAD).
Analysis of genetic polymorphisms related to thrombosis and other risk factors in patients with retinal vein occlusion.
Analysis of metabolism-related indicators and MTHFR gene polymorphism in patients with H-type hypertension.
Analysis of polymorphisms in genes (AGT, MTHFR, GPIIIa, and GSTP1) associated with hypertension, thrombophilia and oxidative stress in Mestizo and Amerindian populations of México.
Assessment of genetic risk for myocardial infarction.
Association between the MTHFR C677T gene polymorphism and essential hypertension in South West Cameroon.
Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
Association of a methylene tetrahydrofolate reductase C677T polymorphism with several blood chemical levels in a Chinese population.
Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene with hypertension in pregnancy and pre-eclampsia: a meta-analysis.
Association of common variants in/near six genes (ATP2B1, CSK, MTHFR, CYP17A1, STK39 and FGF5) with blood pressure/hypertension risk in Chinese children.
Association of COMT G675A and MTHFR C677T polymorphisms with hypertensive disorders of pregnancy in Mexican mestizo population.
Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary risk factors.
Association of Methylene Tetrahydrofolate Reductase C677T Genotype With Type 2 Diabetes Mellitus Patients With and Without Renal Complications.
Association of methylenetetrahydrofolate reductase gene (C677T) with the risk of hypertension in Morocco.
Association of Methylenetetrahydrofolate Reductase Gene 677C>T Polymorphism with Hypertension in Older Women in a Population of Buenos Aires City.
Association of methylenetetrahydrofolate reductase gene C677T polymorphism with polycystic ovary syndrome risk: a systematic review and meta-analysis update.
Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population.
Association of MTHFR C677T and A1298C gene polymorphisms with hypertension.
Association of MTHFR genetic polymorphisms with venous thromboembolism in Uyghur population in Xinjiang, China.
Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure.
Associations of MTHFR and MTRR Polymorphisms With Serum Lipid Levels in Chinese Hypertensive Patients.
Associations of MTHFR Gene Polymorphisms with Hypertension and Hypertension in Pregnancy: A Meta-Analysis from 114 Studies with 15411 Cases and 21970 Controls.
Associations of plasma homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism with carotid intima media thickness among South Asian, Chinese and European Canadians.
B-vitamins, methylenetetrahydrofolate reductase (MTHFR) and hypertension.
Blood pressure and hypertension are associated with 7 loci in the Japanese population.
Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial.
C677T polymorphism of the 5,10 MTHFR gene in young Mexican subjects with ST-elevation myocardial infarction.
Case-control Study of methylenetetrahydrofolate reductase mutations and hyperhomocysteinemia and risk of stroke.
Cerebrovascular risk factors and MRI abnormalities in migraine.
Clinical characteristics of H-type hypertension and its relationship with the MTHFR C677T polymorphism in a Zhuang population from Guangxi, China.
Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.
Connection between small vessel disease related stroke and the MTHFR C677T polymorphism in a Hungarian population.
Critical review of nutrition, blood pressure and risk of hypertension through the lifecycle: do B vitamins play a role?
DNA methylation of hypertension-related genes and effect of riboflavin supplementation in adults stratified by genotype for the MTHFR C677T polymorphism.
Dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization.
Effects of methionine synthase and methionine synthase reductase polymorphisms on hypertension susceptibility.
Effects of MTHFR and MS gene polymorphisms on baseline blood pressure and Benazepril effectiveness in Chinese hypertensive patients.
Epistasis analysis of metabolic genes polymorphisms associated with ischemic heart disease in Yucatan.
Etiological factors in young patients with Retinal Vein Occlusion.
Evidence of a Role for One-Carbon Metabolism in Blood Pressure: Can B Vitamin Intervention Address the Genetic Risk of Hypertension Owing to a Common Folate Polymorphism?
Evidence on the causal link between homocysteine and hypertension from a meta-analysis of 40 173 individuals implementing Mendelian randomization.
Functional Polymorphism rs13306560 of the MTHFR Gene Is Associated With Essential Hypertension in a Mexican-Mestizo Population.
Genetic and environmental influences on total plasma homocysteine and coronary artery disease (CAD) risk among South Indians.
Genetic polymorphism of 5,10-methylenetetrahydrofolate increases risk of myocardial infarction and is correlated to elevated levels of homocysteine in the Japanese general population.
Genetic thromobophilia in pregnancy: a case-control study among North Indian women.
GST M1/T1 and MTHFR polymorphisms as risk factors for hypertension.
Homocysteine and nitrite levels are modulated by MTHFR 677C>T polymorphism in obese women treated with simvastatin.
Homocysteine and the C677T Gene Polymorphism of Its Key Metabolic Enzyme MTHFR Are Risk Factors of Early Renal Damage in Hypertension in a Chinese Han Population.
Homocysteine, the MTHFR 677C>T polymorphism and hypertension: effect modifiers by lifestyle factors and population subgroups.
Homozygous methylentetrahydrofolate reductase C667T genotype anticipates age at venous thromboembolism by one decade.
Identifying multiple causative genes at a single GWAS locus.
Impact of the common MTHFR 677C?T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project.
Impact of the MTHFR C677T polymorphism on one-carbon metabolites: Evidence from a randomised trial of riboflavin supplementation.
Individual and Joint Associations of Methylenetetrahydrofolate Reductase C677T Genotype and Plasma Homocysteine With Dyslipidemia in a Chinese Population With Hypertension.
Interactions between the single nucleotide polymorphisms in the homocysteine pathway (MTHFR 677C>T, MTHFR 1298 A>C, and CBSins) and the efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular disease in high-risk patients of hypertension: the GenHAT study.
Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension Susceptibility.
Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya.
Investigation of homocysteine-pathway-related variants in essential hypertension.
Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?
Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study.
Lack of association between methylenetetrahydrofolate reductase (MTHFR) C677T and ischaemic heart disease (IHD): family-based association study in a Spanish population.
Low plasma pyridoxal 5'-phosphate concentration and MTHFR 677C-->T genotypes are associated with increased risk of hypertension.
MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate.
Methylenetetrahydrofolate reductase (MTHFR) polymorphism A1298C (Glu429Ala) predicts decline in renal function over time in the African-American Study of Kidney Disease and Hypertension (AASK) Trial and Veterans Affairs Hypertension Cohort (VAHC).
Methylenetetrahydrofolate Reductase C677T Gene Polymorphism as a Risk Factor for Hypertension in a Rural Population.
Methylenetetrahydrofolate reductase C677T polymorphism, hypertension and risk of stroke: a prospective, nested case-control study.
Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myocardial infarction.
Methylenetetrahydrofolate reductase gene polymorphism, global DNA methylation and blood pressure: a population based study from North India.
Methylenetetrahydrofolate reductase gene polymorphism: relation to blood pressure and cerebrovascular disease.
Methylenetetrahydrofolate reductase gene polymorphisms in essential hypertension relation: with the development of hypertensive end-stage renal disease.
Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study.
Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes.
Methylenetetrahydrofolate reductase polymorphism, folate, and susceptibility to preeclampsia.
Methylenetetrahydrofolate reductase variants associated with hypertension and cardiovascular disease interact with dietary polyunsaturated Fatty acids to modulate plasma homocysteine in puerto rican adults.
Modeling premature occurrence of acute coronary syndrome with atherogenic and thrombogenic risk factors and gene markers in extended families.
MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians.
MTHFR C677T polymorphism affects normotensive diastolic blood pressure independently of blood lipids.
MTHFR C677T polymorphism among Meiteis of Manipur (India).
MTHFR C677T polymorphism and hypertension.
Plasma homocysteine in patients with retinal vein occlusion.
Plasma homocysteine, MTHFR C677T, CBS 844ins68bp, and MTHFD1 G1958A polymorphisms in spontaneous cervical artery dissections.
Plasma total homocysteine levels and methylenetetrahydrofolate reductase gene polymorphism in patients with type 2 diabetes mellitus.
Polymorphism of methylenetetrahydrofolate reductase gene (C677T MTHFR) is not a confounding factor of the relationship between serum uric acid level and the prevalence of hypertension in Japanese men.
Polymorphism of MTHFR C677T Gene and the Associations with the Severity of Essential Hypertension in Northern Chinese Population.
Postgraduate Symposium: The MTHFR C677T polymorphism, B-vitamins and blood pressure.
PP004. The polymorphism C677T of methylenetetrahydrofolate reductase (MTHFR), may increase risk for future higher blood pressure in women with previous hypertension in pregnancy.
Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension.
Prospective study of first stroke in relation to plasma homocysteine and MTHFR 677C>T and 1298A>C genotypes and haplotypes - evidence for an association with hemorrhagic stroke.
Recapitulation of four hypertension susceptibility genes (CSK, CYP17A1, MTHFR, and FGF5) in East Asians.
Relationship between two sequence variations in the gene for peroxisome proliferator-activated receptor-gamma and plasma homocysteine concentration. Health in men study.
Renal vascular sclerosis is associated with inherited thrombophilias.
Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up.
Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition.
Riboflavin, MTHFR genotype and blood pressure: A personalized approach to prevention and treatment of hypertension.
Risk Factors for Thrombosis Development in Mexican Patients.
Serum levels of miR-199a-5p correlates with blood pressure in premature cardiovascular disease patients homozygous for the MTHFR 677C?>?T polymorphism.
Signaling pathway genes for blood pressure, folate and cholesterol levels among hypertensives: an epistasis analysis.
Strong association of methylenetetrahydrofolate reductase gene C677T polymorphism with hypertension and hypertension-in-pregnancy in Chinese: a meta-analysis.
Study on homocysteine levels and methylenetetrahydrofolate reductase gene variant (C677T) in a population of Buenos Aires city.
Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation.
The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia.
The association between inherited thrombophilias and pregnancy-related hypertension recurrence.
The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are associated with hyperhomocysteinemia and cardiovascular disease in hemodialysis patients.
The effect of methylenetetrahydrofolate reductase C677T common variant on hypertensive risk is not solely explained by increased plasma homocysteine values.
The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease.
The importance of MTHFR, MTR, MTRR and CSE expression levels in Caucasian women with preeclampsia.
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China.
The Methylenetetrahydrofolate Reductase C677T (rs1801133) and Apolipoprotein A5-1131T>C (rs662799) Polymorphisms, and Anemia Are Independent Risk Factors for Ischemic Stroke.
The modifying effect of the MTHFR genotype on the association between folic acid supplementation and pulse wave velocity: Findings from the CSPPT.
The prevalence, relative risk factors and MTHFR C677T genotype of H type hypertension of the elderly hypertensives in Shanghai, China: a cross-section study : Prevalence of H type hypertension.
The relationship between MTHFR C677T gene polymorphism and essential hypertension in a sample of an Algerian population of Oran city.
The Role of Polymorphism Gen Methylene Tetra Hydrofolate Reductase (MTHFR) C677T in Ischaemic Stroke Patients with and Without Hypertension.
Total plasma homocysteine is associated with hypertension in Type I diabetic patients.
Volume of white matter hyperintensities in healthy adults: Contribution of age, vascular risk factors, and inflammation-related genetic variants.
Zinc Finger 259 Gene Polymorphism rs964184 is Associated with Serum Triglyceride Levels and Metabolic Syndrome.
[Arterial Hypertension and Methylenetetrahydrofolate Reductase C677T Gene Polymorphism].
[FETAL LOSSES DURING THE MATURATION OF THE PLACENTA AND THE RELATIONSHIP WITH SOME PROCOAGULANT CONDITIONS.]
[Genetic determinants of hypertension in two national cohorts of Mountain Shoria].
[Left Ventricular Myocardial Hypertrophy as a Result of Arterial Hypertension Among Mountain Shoria Population. The Role of Genetic Polymorphism].
[New potential of MTHFR gene variations application as an individual sensitivity marker in evaluation of occupational risk of arterial hypertension under exposure to nose].
[Relationships between polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase genes and genetic susceptibility to pregnancy induced hypertension]
[Study on the relationship between methylenetetrahydrofolate reductase gene polymorphism and plasma homocysteine level in pregnancy induced hypertension patients]
[The normotensive carriers of the MTHFR 677T allele, displaying the increased risk of development of the abdominal aortic aneurysm (AAA), occur at the highest frequency among the smoking patients]
[The role of homocysteine and methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase polymorphisms in the development of cardiovascular diseases and hypertension].
Hypertension, Pregnancy-Induced
Correlation between MTHFR gene polymorphism and homocysteine levels for prognosis in patients with pregnancy-induced hypertension.
Genetic thromobophilia in pregnancy: a case-control study among North Indian women.
Localization of folate metabolic enzymes, methionine synthase and 5,10-methylenetetrahydrofolate reductase in human placenta.
Methylenetetrahydrofolate Reductase Enzyme Level and Antioxidant Activity in Women with Gestational Hypertension and Pre-eclampsia in Lagos, Nigeria.
Methylenetetrahydrofolate reductase polymorphisms and the risk of gestational hypertension.
The search for thrombophilic gene mutations in women with gestational hypertension does not help in predicting poor pregnancy outcome.
[Relationships between polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase genes and genetic susceptibility to pregnancy induced hypertension]
[Study on the relationship between methylenetetrahydrofolate reductase gene polymorphism and plasma homocysteine level in pregnancy induced hypertension patients]
Hypertension, Pulmonary
Prevalence of variants in methylenetetrahydrofolate reductase and the severity of pulmonary vascular disease.
Hypertension, Renovascular
Co-existence of renovascular hypertension, polyarteritis nodosa, antiphospholipid syndrome and methylenetetrahydrofolate reductase mutation.
Postoperative Symptomatic Cerebral Infarction in Pediatric Moyamoya Disease: Risk Factors and Clinical Outcome.
Hypertensive Retinopathy
Improving diabetic and hypertensive retinopathy with a medical food containing L-methylfolate: a preliminary report.
Hyperthyroidism
MTHFR gene polymorphisms in hypothyroidism and hyperthyroidism among Jordanian females.
Postoperative Symptomatic Cerebral Infarction in Pediatric Moyamoya Disease: Risk Factors and Clinical Outcome.
Hypertriglyceridemia
A comparison of the genetic and clinical risk factors for arterial hypertension between indigenous and non-indigenous people of the Shoria Mountain Region.
Associations of homocysteine status and homocysteine metabolism enzyme polymorphisms with hypertension and dyslipidemia in a Chinese hypertensive population.
Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency.
Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study.
Hypertrophy, Left Ventricular
Relationship Between Gene Polymorphism of Methylenetetrahydrofolate Reductase C677T and Left Ventricular Hypertrophy in Chinese Patients with Chronic Kidney Disease.
Renal Insufficiency in Non-Diabetic Subjects: Relationship of MTHFR C677t Gene Polymorphism and Left Ventricular Hypertrophy.
Hypoparathyroidism
antiphospholipid antibodies syndrome associated with hyperhomocysteinemia related to MTHFR Gene C677T and A1298C heterozygous mutations in a young man with idiopathic hypoparathyroidism (DiGeorge syndrome).
Hypopituitarism
Combined choroidal neovascularization and hypopituitarism in a patient with homozygous mutation in methylenetetrahydrofolate reductase gene.
Hypoplastic Left Heart Syndrome
Methylenetetrahydrofolate Reductase C677T: Hypoplastic Left Heart and Thrombosis.
Hypospadias
Interaction between MTHFR 677C>T and periconceptional folic acid supplementation in the risk of Hypospadias.
Hypothyroidism
An unusually high plasma concentration of homocysteine resulting from a combination of so-called "secondary" etiologies.
Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms in Georgian Females with Hypothyroidism.
MTHFR GENE C677T POLYMORPHISM AND LEVELS OF DNA METHYLTRASFERASES IN SUBCLINICAL HYPOTHYROIDISM.
MTHFR gene polymorphisms in hypothyroidism and hyperthyroidism among Jordanian females.
Hypoventilation
[Genotype and phenotype analysis of neonates with neonatal encephalopathy complicated with perinatal hypoxic event].
Ichthyosis Vulgaris
[ANALYSIS OF ONE-CARBON METABOLISM GENES AND EPIDERMAL DIFFERENTIATION COMPLEX IN PATIENTS WITH ICHTHYOSIS VULGARIS].
Infections
A systematic review of meta-analyses on gene polymorphisms and gastric cancer risk.
Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis patients without Helicobacter pylori infection: a case control study.
Association of Mycobacterium infections in patients with Mendelian susceptibility to mycobacterial disease with venous thromboembolism.
Associations between MTHFR Ala222Val polymorphism and risks of hepatitis and hepatitis-related liver cancer: a meta-analysis.
COVID-19 spreading across world correlates with C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene prevalence.
Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses.
Distribution of p53, GST, and MTHFR polymorphisms and risk of cervical intraepithelial lesions in sicily.
Genetic Polymorphism of MTHFR C677T Influences Susceptibility to HBV-Related Hepatocellular Carcinoma in a Chinese Population: a Case-Control Study.
Impact of methylenetetrahydrofolate reductase C677T polymorphism on the risk of gastric cancer and its interaction with Helicobacter pylori infection.
Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site.
Increased Resistance to Malaria in Mice with Methylenetetrahydrofolate Reductase (Mthfr) Deficiency Suggests a Mechanism for Selection of the MTHFR 677C>T (c.665C>T) Variant.
Investigation of Methylenetetrahydrofolate Reductase C677T Polymorphism and Human Papilloma Virus Genotypes in Iranian Breast Cancer.
Lack of association between methylenetetrahydrofolate reductase C677T polymorphism, HPV infection and cervical intraepithelial neoplasia in Brazilian women.
Methylene Tetrahydrofolate Reductase Gene Polymorphism is Associated with Severity of Liver Steatosis in Chronically Infected Patients with HCV Genotype 4.
Methylenetetrahydrofolate reductase (MTHFR) deficiency enhances resistance against cytomegalovirus infection.
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and promoter methylation in cervical oncogenic lesions and cancer.
Methylenetetrahydrofolate reductase 677 T allele protects against persistent HBV infection in West Africa.
Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemia.
MTHFR C677T polymorphism and differential methylation status in gastric cancer: an association with Helicobacter pylori infection.
MTHFR Polymorphisms and Opisthorchis viverrini Infection: a Relationship with Increased Susceptibility to Cholangiocarcinoma in Thailand.
No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese.
Possible roles of methylenetetrahydrofolate reductase polymorphism and folate status in patients with early hepatitis C virus genotype 4.
Posterior cerebral artery occlusion after Mycoplasma pneumoniae infection associated with genetic defect of MTHFR C677T.
Rapidly progressive psychotic symptoms triggered by infection in a patient with methylenetetrahydrofolate reductase deficiency: a case report.
The combination of methylenehydrofolate reductase C677T polymorphism screening and gastrointestinal tumor markers detection may be an early screening method for gastrointestinal cancer related to helicobacter pylori infection.
The effect of methylenetetrahydrofolate reductase polymorphisms on susceptibility to human papilloma virus infection and cervical cancer.
The Impact of MTHFR 1298 A?>?C and 677 C?>?T Gene Polymorphisms as Susceptibility Risk Factors in Cervical Intraepithelial Neoplasia Related to HPV and Sexually Transmitted Infections.
The incidence of severe intraventricular hemorrhage based on retrospective analysis of 35939 full-term newborns-report of two cases and review of literature.
The MTHFR C677T mutation is not a risk factor recognized for HBV-related HCC in a population with a high prevalence of this genetic marker.
Thrombogenic alleles, Escherichia coli O157:H7 infections, and hemolytic uremic syndrome.
[C677T polymorphism of the MTHFR gene and the risk of developing distal gastric cancer in a Mexican population]
[FETAL LOSSES DURING THE MATURATION OF THE PLACENTA AND THE RELATIONSHIP WITH SOME PROCOAGULANT CONDITIONS.]
Infertility
5-Methyltetrahydrofolate reduces blood homocysteine level significantly in C677T methyltetrahydrofolate reductase single-nucleotide polymorphism carriers consulting for infertility.
A Association of MTHFR C677T and MTRR A66G Gene Polymorphisms with Iranian Male Infertility and Its Effect on Seminal Folate and Vitamin B12.
A hidden cause of infertility in hypothyroid patients.
Association of a miR-34b binding site single nucleotide polymorphism in the 3'-untranslated region of the methylenetetrahydrofolate reductase gene with susceptibility to male infertility.
Association of the MTHFR C677T (rs1801133) polymorphism with idiopathic male infertility in a local Pakistani population.
Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men.
C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration.
Effects of folic acid on oligozoospermia with MTHFR polymorphisms in term of seminal parameters, DNA fragmentation, and live birth rate: a double-blind, randomized, placebo-controlled trial.
Embryonic MTHFR contributes to blastocyst development.
Folic acid supplementation and methylenetetrahydrofolate reductase (MTHFR) gene variations in relation to in vitro fertilization pregnancy outcome.
High doses of folic acid induce a pseudo-methylenetetrahydrofolate syndrome.
Hyperhomocysteinemia in women with unexplained sterility or recurrent early pregnancy loss from Southern Italy: a preliminary report.
Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation.
Inherited thrombophilia in infertile women-implication in unexplained infertility.
Interaction of thrombophilic SNPs in patients with unexplained infertility-multifactor dimensionality reduction (MDR) model analysis.
Methylenetetrahydrofolate reductase C677T polymorphism is not associated with male infertility in a South Indian population.
MTHFR (methylenetetrahydrofolate reductase: EC 1.5.1.20) SNPs (single-nucleotide polymorphisms) and homocysteine in patients referred for investigation of fertility.
MTHFR C677T and A1298C Genotypes and Haplotypes in Slovenian Couples with Unexplained Infertility Problems and in Embryonic Tissues from Spontaneous Abortions.
MTHFR C677T polymorphism, GSTM1 deletion and male infertility: a possible suggestion of a gene-gene interaction?
MTHFR promoter hypermethylation in testicular biopsies of patients with non-obstructive azoospermia: the role of epigenetics in male infertility.
Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.
Polymorphisms in Folate-Related Enzyme Genes in Idiopathic Infertile Brazilian Men.
Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.
Prevalence of the MTHFR C677T Mutation in Fertile and Infertile Women.
Prospective study of MTHFR genetic polymorphisms as a possible etiology of male infertility.
Relationship Between Genetic Polymorphisms of Methylenetetrahydrofolate Reductase (C677T, A1298C, and G1793A) as Risk Factors for Idiopathic Male Infertility.
Role of 677C?T polymorphism a single substitution in methylenetetrahydrofolate reductase (MTHFR) gene in North Indian infertile men.
Role of genetic mutations in folate-related enzyme genes on Male Infertility.
Significant impact of the MTHFR polymorphisms and haplotypes on male infertility risk.
Single nucleotide polymorphism C677T in the methylenetetrahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia.
Spontaneous pregnancies in patients with at least one failed IVF cycle after the management of autoimmune disorders, hereditary thrombophilia, and methylation disorders.
Stability of DNA Methylation Patterns in Mouse Spermatogonia Under Conditions of MTHFR Deficiency and Methionine Supplementation.
Strain-Specific Defects in Testicular Development and Sperm Epigenetic Patterns in 5,10-Methylenetetrahydrofolate Reductase-Deficient Mice.
The relationship between methylenetetrahydrofolate reductase c.677TT genotype and oligozoospermia in infertile male patients living in the Trakya region of Turkey.
Thrombophilic gene polymorphisms are risk factors for unexplained infertility.
Thrombophilic mutations in Iranian patients with infertility and recurrent spontaneous abortion.
Variations in folate pathway genes are associated with unexplained female infertility.
[Relationship of MTHFR gene polymorphisms with infertility].
[The occurence of genetic trombophilic markers in patients evaluated for infertility].
Infertility, Female
Hyperhomocysteinemia in women with unexplained sterility or recurrent early pregnancy loss from Southern Italy: a preliminary report.
Infertility, Male
A Association of MTHFR C677T and MTRR A66G Gene Polymorphisms with Iranian Male Infertility and Its Effect on Seminal Folate and Vitamin B12.
Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis.
Association between genetic polymorphisms in folate-related enzyme genes and infertile men with non-obstructive azoospermia.
Association between methionine synthase reductase A66G polymorphism and primary infertility in Chinese males.
Association between methylenetetrahydrofolate reductase (MTHFR) gene promoter hypermethylation and the risk of idiopathic male infertility.
Association between MTHFR A1298C polymorphism and male infertility: A meta-analysis.
Association between the MTHFR-C677T isoform and structure of sperm DNA.
Association of a miR-34b binding site single nucleotide polymorphism in the 3'-untranslated region of the methylenetetrahydrofolate reductase gene with susceptibility to male infertility.
Association of C677T transition of the human methylenetetrahydrofolate reductase (MTHFR) gene with male infertility.
Association of MTHFR, NFKB1, NFKBIA, DAZL and CYP1A1 gene polymorphisms with risk of idiopathic male infertility in a Han Chinese population.
Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with male infertility: a meta-analysis.
Association of the methylenetetrahydrofolate reductase gene C677T polymorphism with the risk of male infertility: a meta-analysis.
Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis.
Association of the MTHFR A1298C variant with unexplained severe male infertility.
Association of the MTHFR C677T (rs1801133) polymorphism with idiopathic male infertility in a local Pakistani population.
Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population.
Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility.
Associations of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene with male infertility risk: A meta-analysis.
Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men.
Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population.
Correlation between methylenetetrahydrofolate reductase gene polymorphism and oligoasthenospermia and the effects of folic acid supplementation on semen quality.
Cystathionine B-Synthase 844ins68 Gene Variant and Idiopathic Male Infertility.
Epigenetics of Male Infertility: The Role of DNA Methylation.
Epigenetics, spermatogenesis and male infertility.
Folate and vitamin B(12) in idiopathic male infertility.
Homozygous methylenetetrahydrofolate reductase C677T mutation and male infertility.
Human MTHFR-G1793A transition may be a protective mutation against male infertility: a genetic association study and in silico analysis.
Idiopathic male infertility is strongly associated with aberrant promoter methylation of methylenetetrahydrofolate reductase (MTHFR).
Influence of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms in Algerian Infertile Men with Azoospermia or Severe Oligozoospermia.
Is methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism related with varicocele risk?
Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population.
Lack of association of MTHFR rs1801133 polymorphism and CTCFL mutations with sperm methylation errors in infertile patients.
Methylation pattern of methylene tetrahydrofolate reductase and small nuclear ribonucleoprotein polypeptide N promoters in oligoasthenospermia: a case-control study.
Methylation patterns of methylenetetrahydrofolate reductase gene promoter in infertile males.
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis.
Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk for Male Infertility in Asian Population.
Methylenetetrahydrofolate reductase C677T polymorphism and the risk of male infertility: a meta-analysis.
Methylenetetrahydrofolate reductase C677T polymorphism is not associated with male infertility in a South Indian population.
Methylenetetrahydrofolate reductase gene promoter hypermethylation in semen samples of infertile couples correlates with recurrent spontaneous abortion.
Methylenetetrahydrofolate reductase polymorphisms are related to male infertility in Brazilian men.
MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis.
MTHFR 677C>T polymorphism increases the male infertility risk: a meta-analysis involving 26 studies.
MTHFR A1298C polymorphism and idiopathic male infertility.
MTHFR C677T polymorphism associates with unexplained infertile male factors.
MTHFR C677T polymorphism, GSTM1 deletion and male infertility: a possible suggestion of a gene-gene interaction?
MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis.
MTHFR polymorphisms as risk for male infertility in Pakistan and its comparison with socioeconomic status in the world.
MTHFR promoter hypermethylation in testicular biopsies of patients with non-obstructive azoospermia: the role of epigenetics in male infertility.
MTHFR-Ala222Val and male infertility: a study in Iranian men, an updated meta-analysis and an in silico-analysis.
Mutation C677T in the methylenetetrahydrofolate reductase gene is associated with male infertility in an Indian population.
Prospective study of MTHFR genetic polymorphisms as a possible etiology of male infertility.
Relationship Between Genetic Polymorphisms of Methylenetetrahydrofolate Reductase (C677T, A1298C, and G1793A) as Risk Factors for Idiopathic Male Infertility.
Role of genetic mutations in folate-related enzyme genes on Male Infertility.
Significant impact of the MTHFR polymorphisms and haplotypes on male infertility risk.
Single nucleotide polymorphism C677T in the methylenetetrahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia.
Strong Association of 677 C>T Substitution in the MTHFR Gene with Male Infertility - A Study on an Indian Population and a Meta-Analysis.
The methylenetethrahydrofolate reductase (MTHFR) C677T polymorphism and male infertility in Italy.
The relationship between the C677T polymorphism of the MTHFR gene and serum levels of luteinizing hormone in males with erectile dysfunction.
The relevance of MTHFR C677T, A1298C, and MTRR A66G polymorphisms with response to male infertility in Asians: A meta-analysis.
The SLC19A1 80G>A polymorphism is not associated with male infertility.
[Genetic causes of male infertility]
[MTHFR gene polymorphism and male infertility]
[The effect of polymorphisms C677T and 1298 gene MTHFR on the reproductive function of men].
Inflammatory Bowel Diseases
Factor V Leiden G1691A, prothrombin G20210A, and MTHFR C677T mutations in Turkish inflammatory bowel disease patients.
Factor V Leiden, prothrombin G20210A and MTHFR gene mutations in inflammatory bowel disease.
Hyperhomocysteinemia and methylenetetrahydrofolate reductase 677C-->T and 1298A-->C mutations in patients with inflammatory bowel disease.
Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications.
Methylenetetrahydrofolate reductase C677T variant in Moroccan patients with inflammatory bowel disease.
Prevalence of methylenetetrahydrofolate reductase polymorphisms in young patients with inflammatory bowel disease.
The association of the MTHFR C677T polymorphism with inflammatory bowel diseases in the Israeli Jewish population: An example of genetic heterogeneity.
The methylenetetrahydrofolate reductase 1298 A>C polymorphism is associated with an increased risk of inflammatory bowel disease: evidence from a meta-analysis.
Insulin Resistance
Association of homocysteinemia with high concentrations of serum insulin and uric acid in Brazilian subjects with metabolic syndrome genotyped for C677T polymorphism in the methylenetetrahydrofolate reductase gene.
Associations of MTHFR C677T polymorphism with insulin resistance, results of NURSE Study (Nursing Unacquainted Related Stress Etiologies).
C-reactive protein, vitamin B12 and C677T polymorphism of N-5,10-methylenetetrahydrofolate reductase gene are related to insulin resistance and risk factors for metabolic syndrome in Chinese population.
Genetic polymorphism of Methylenetetrahydrofolate reductase is associated with insulin resistance in Egyptian women with polycystic ovary syndrome.
Interactions between genetic variants involved in the folate metabolic pathway and serum lipid, homocysteine levels on the risk of recurrent spontaneous abortion.
Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants.
Methylenetetrahydrofolate reductase 677 C->T polymorphism: A link between birth weight and insulin resistance in obese adolescents.
The Insulin-like Growth Factor-1 (G>A) and 5,10-methylenetetrahydrofolate Reductase (C677T) Gene Variants and the Serum Levels of Insulin-like Growth Factor-1, Insulin, and Homeostasis Model Assessment in Patients with Acne Vulgaris.
[Association of C677T gene polymorphism of methylenetetrahydrofolate reductase with insulin resistance among Kirghizes].
[Smoking enhances the decrease of adiponectin level in patients with coronary artery disease, carriers of MTHFR 677T and PON1 55M alleles].
Intellectual Disability
Infant C677T MTHFR polymorphism and severe mental retardation.
Lack of association between MTHFR C677T and MTHFR A1298C genetic polymorphisms and mental retardation.
Methylenetetrahydrofolate reductase deficiency in a patient with phenotypic findings of Angelman syndrome.
Screening for methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Indian patients with idiopathic mental retardation.
Spine and brain malformations in a patient obligate carrier of MTHFR with autism and mental retardation.
Intermittent Claudication
Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes.
Intracranial Aneurysm
Polymorphisms of homocysteine metabolism are associated with intracranial aneurysms.
Intracranial Arteriosclerosis
Association of Homocysteine with Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.
Intracranial Hemorrhages
Associations between MTHFR gene polymorphisms and the risk of intracranial hemorrhage: Evidence from a meta-analysis.
Intracranial Thrombosis
Significance of factor V, prothrombin, MTHFR, and PAI-1 genotypes in childhood cerebral thrombosis.
Ischemic Attack, Transient
C677T MTHFR mutation and factor V Leiden mutation in patients with TIA/minor stroke: a case-control study.
Cerebral Venous Sinus Thrombosis Presenting as Transient Ischemic Attacks in a Case With Homozygous Mutations of MTHFR A1298C and CG677T.
Genetic and nongenetic factors influencing plasma homocysteine levels in patients with ischemic cerebrovascular disease and in healthy control subjects.
Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine.
Sequential multiple retinal vein occlusions and transient ischemic attack in MTHFR polymorphism and protein S deficiency.
Successful treatment of brain ischemia with supplementation therapy in a patient with hyperhomocysteinemia.
Transient ischemic attacks in a child with post-varicella arteriopathy and MTHFR homozigotic mutation C677T.
[Hyperhomocysteine, methylenetetrahydrofolate reductase gene, and other risk factors in ischemic stroke]
Ischemic Stroke
5,10-methylenetetrahydrofolate reductase C677T gene polymorphism and peripheral arterial disease: A meta-analysis.
A case of vascular parkinsonism associated with hyperhomocysteinemia and methylenetetrahydrofolate reductase gene variant (C677T).
A methylenetetrahydrofolate reductase gene polymorphism in ischaemic stroke and in carotid artery stenosis.
A plasma proteomics method reveals links between ischemic stroke and MTHFR C677T genotype.
A possible synergistic effect of MTHFR C677T polymorphism on homocysteine level variations increased risk for ischemic stroke.
A potential epigenetic marker mediating serum folate and vitamin B 12 levels contributes to the risk of ischemic stroke.
An analysis of methylenetetrahydrofolate reductase and glutathione S-transferase omega-1 genes as modifiers of the cerebral response to ischemia.
An association between methylenetetrahydrofolate reductase (C677T) polymorphism and large-artery ischemic stroke.
An association of 5,10-Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphism and ischemic stroke.
Antiphospholipid antibodies in neonates with stroke--a unique entity or variant of antiphospholipid syndrome?
Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies.
Association between Glu298Asp single nucleotide polymorphism in the eNOS/MTHRF gene and blood stasis syndrome of ischemic stroke.
Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke.
Association between methylene tetrahydrofolate reductase polymorphisms and risk of ischemic stroke.
Association between methylenetetrahydrofolate reductase (MTHFR) polymorphism and carotid intima medial thickness progression in post ischaemic stroke patient.
Association between the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and ischemic stroke in the Chinese population: a meta-analysis.
Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population.
Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR gene) with ischemic stroke: a meta-analysis.
Association of CVD candidate gene polymorphisms with ischemic stroke and cerebral hemorrhage in Chinese individuals.
Association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with ischemic stroke in the Eastern Chinese Han population.
Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype.
Association of the A1298C polymorphism in MTHFR gene with ischemic stroke.
Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with stroke risk based on a meta-analysis.
Association studies of genetic polymorphism, environmental factors and their interaction in ischemic stroke.
Association study between genetic polymorphisms in folate metabolism and gastric cancer susceptibility in Chinese Han population: A case-control study.
C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of ischemic stroke in Polish subjects.
Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants.
Clinical and Genetic Heterogeneity in a Large Family with Pseudoxanthoma Elasticum: MTHFR and SERPINE1 Variants as Possible Disease Modifiers in Developing Ischemic Stroke.
Clinical Relevance of MTHFR, eNOS, ACE, and ApoE Gene Polymorphisms and Serum Vitamin Profile among Malay Patients with Ischemic Stroke.
Coagulation factor V G1691A, factor II G20210A and methylenetetrahydrofolate reductase C677T gene mutations do not play a major role in symptomatic neonatal arterial ischaemic stroke.
Common genetic markers and prediction of recurrent events after ischemic stroke in young adults.
Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study.
Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran.
Connection between genetically determined blood coagulation factors and haemorheology.
Correlation with Platelet Parameters and Genetic Markers of Thrombophilia Panel (Factor II g.20210G>A, Factor V Leiden, MTHFR (C677T, A1298C), PAI-1, ?-Fibrinogen, Factor XIIIA (V34L), Glycoprotein IIIa (L33P)) in Ischemic Strokes.
Detailed analysis of gene polymorphisms associated with ischemic stroke in South asians.
Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis.
Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism.
Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke, but methylenetetrahydrofolate reductase gene C677T polymorphism was a risk factor for thrombotic stroke: a Multicenter Case-Control Study in China.
Endothelial Dysfunction May Link Interatrial Septal Abnormalities and MTHFR-Inherited Defects to Cryptogenic Stroke Predisposition.
Endothelial nitric oxide synthase gene interactions and the risk of ischaemic stroke.
Evaluation of MTHFR C677T polymorphism in ischemic and hemorrhagic stroke patients. A case-control study in a Northern Indian population.
Evaluation of the interactions of common genetic mutations in stroke subtypes.
Evaluation of the interactions of common genetic mutations in stroke.
Evaluation of the modifying effects of unfavourable genotypes on classical clinical risk factors for ischaemic stroke.
Factor V Leiden, prothrombin gene G20210A variant, and methylenetetrahydrofolate reductase C677T genotype in young adults with ischemic stroke.
Gene polymorphisms of homocysteine metabolism-related enzymes in Chinese patients with occlusive coronary artery or cerebral vascular diseases.
Gene-environment interactions between methylenetetrahydrofolate reductase (MTHFR) 677C>T and metabolic syndrome for the prevalence of ischemic stroke in Koreans.
Gene-gene and gene-environment interplay represent specific susceptibility for different types of ischaemic stroke and leukoaraiosis.
Genetic analysis of the thermolabile variant of 5, 10-methylenetetrahydrofolate reductase as a risk factor for ischemic stroke.
Genetic polymorphisms of Chinese patients with ischemic stroke and concurrent stenoses of extracranial and intracranial vessels.
Genetic polymorphisms of methylenetetrahydrofolate reductase C677T and risk of ischemic stroke in a southern Chinese Hakka population.
Genetic Risk Factors for Arterial Ischemic Stroke in Children: A Possible MTHFR and eNOS Gene-Gene Interplay?
High MTHFR promoter methylation levels in men confer protection against ischemic stroke.
Homocysteine, MTHFR 677C-->T polymorphism, and risk of ischemic stroke: results of a meta-analysis.
Homocysteine, MTHFR C677 T, vitamin B12, and folate levels in Thai children with ischemic stroke: a case-control study.
Homozygous C677T mutation in the MTHFR gene as an independent risk factor for multiple small-artery occlusions.
Homozygous C677T mutation of the 5,10 methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in Italian patients with a history of early-onset ischemic stroke.
Homozygous thermolabile variant of the methylenetetrahydrofolate reductase gene: a potential risk factor for hyperhomocysteinaemia, CVD, and stroke in childhood.
Hyperhomocysteinemia and hypofibrinolysis in young adults with ischemic stroke.
Hyperhomocysteinemia, C677T MTHFR polymorphism and ischemic stroke in Tunisian patients.
Influence of combined methionine synthase (MTR 2756A > G) and methylenetetrahydrofolate reductase (MTHFR 677C > T) polymorphisms to plasma homocysteine levels in Korean patients with ischemic stroke.
Inherited prothrombotic conditions and premature ischemic stroke: sex difference in the association with factor V Leiden.
Inherited thrombophilia and stratification of ischaemic stroke risk among users of oral contraceptives.
Inherited thrombophilia as a risk factor for the development of ischemic stroke in young adults.
Interaction Between Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphisms and Environment with Susceptibility to Ischemic Stroke in Chinese Population.
Interaction of serum vitamin B12 and folate with MTHFR genotypes on risk of ischemic stroke.
Interplay between 3'-UTR polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and the risk of ischemic stroke.
Is the 1298A>C polymorphism in the MTHFR gene a risk factor for arterial ischaemic stroke in children? The results of meta-analysis.
Ischaemic stroke following tranexamic acid in young patients carrying heterozygosity of MTHFR C677T.
Ischemic Stroke in a 7-Month-Old Infant With Antiphospholipid Antibody and Homozygous C677T Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism.
Ischemic Stroke in a Patient With Atrial Tachycardia, Methylenetetrahydrofolate Reductase Mutation and New-Onset Atrial Fibrillation: Is Early Initiation of Anticoagulation Therapy Indicated?
Lipoprotein (a) and genetic polymorphisms of clotting factor V, prothrombin, and methylenetetrahydrofolate reductase are risk factors of spontaneous ischemic stroke in childhood.
Longitudinal myelitis in patient with systemic lupus erythematosus, homozygous prothrombin G20210A and heterozygous MTHFR 677T.
Meta-analysis of genetic studies from journals published in China of ischemic stroke in the Han Chinese population.
Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls.
Meta-analysis study to evaluate the association of MTHFR C677T polymorphism with risk of ischemic stroke.
Methylene Tetrahydrofolate Reductase (MTHFR) rs868014 Polymorphism Regulated by miR-1203 Associates with Risk and Short Term Outcome of Ischemic Stroke.
Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes.
Methylenetetrahydrofolate reductase (C677T and A1298C) polymorphisms, hyperhomocysteinemia, and ischemic stroke in Tunisian patients.
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and susceptibility to ischemic stroke: a meta-analysis.
Methylenetetrahydrofolate reductase C677T polymorphism in Iraqi patients with ischemic stroke.
Methylenetetrahydrofolate Reductase CpG Islands: Epigenotyping.
Methylenetetrahydrofolate reductase deficiency alters cellular response after ischemic stroke in male mice.
Methylenetetrahydrofolate reductase gene A1298C polymorphism in pediatric stroke--case-control and family-based study.
Methylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic stroke.
Methylenetetrahydrofolate reductase gene polymorphism and childhood stroke.
Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese.
Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke: sex difference in Japanese.
Methylenetetrahydrofolate reductase gene polymorphism in Indian stroke patients.
Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: Dual effect of MTHFR polymorphisms C677T and A1298C.
Migraine mediates the influence of C677T MTHFR genotypes on ischemic stroke risk with a stroke-subtype effect.
MTHFR (C677T) CT genotype and CT-apoE3/3 genotypic combination predisposes the risk of ischemic stroke.
MTHFR (C677T, A1298C), FV Leiden polymorphisms, and the prothrombin G20210A mutation in arterial ischemic stroke among young tunisian adults.
MTHFR C677T mutation increased the risk of Ischemic Stroke, especially in large-artery atherosclerosis in adults: an updated meta-analysis from 38 researches.
MTHFR C677T polymorphism and its relation to ischemic stroke in the Black Sea Turkish population.
MTHFR Gene Polymorphisms Prevalence and Cardiovascular Risk Factors Involved in Cardioembolic Stroke Type and Severity.
Mutations and Polymorphisms in Genes Affecting Hemostasis Proteins and Homocysteine Metabolism in Children with Arterial Ischemic Stroke.
Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolate reductase gene polymorphism.
Ocular vascular thrombotic events: a diagnostic window to familial thrombophilia (compound factor v leiden and prothrombin gene heterozygosity) and thrombosis.
Plasma homocysteine concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke.
Plasma total homocysteine and the methylenetetrahydrofolate reductase 677C>T polymorphism do not contribute to the distribution of cervico-cerebral atherosclerosis in ischaemic stroke patients.
Polymorphism in the methylenetetrahydrofolate reductase (C677T) gene and homocysteine levels: a comparison in Brazilian patients with coronary arterial disease, ischemic stroke and peripheral arterial obstructive disease.
Polymorphism of the methylenetetrahydrofolate reductase gene association with homocysteine and ischemic stroke in type 2 diabetes.
Polymorphisms of MTHFR, eNOS, ACE, AGT, ApoE, PON1, PDE4D, and Ischemic Stroke: Meta-Analysis.
Prevalence of Thrombophilic Mutations and ACE ID Polymorphism in Turkish Ischemic Stroke Patients.
Prospective study of first stroke in relation to plasma homocysteine and MTHFR 677C>T and 1298A>C genotypes and haplotypes - evidence for an association with hemorrhagic stroke.
Prothrombotic conditions, oral contraceptives, and the risk of ischemic stroke.
Recurrent ischemic strokes in a young celiac woman with MTHFR gene mutation.
Recurrent thromboembolism in infants and children suffering from symptomatic neonatal arterial stroke: a prospective follow-up study.
Relationship between methylenetetrahydrofolate reductase (MTHFR) gene (A1298C) polymorphism with the risk of stroke: A systematic review and meta-analysis.
Role of a common mutation in the homocysteine regulatory enzyme methylenetetrahydrofolate reductase in ischemic stroke.
Role of MTHFR C677T polymorphism in ischemic stroke.
Sonographic evaluation of atherosclerosis burden in carotid arteries of ischemic stroke patients and its relation to paraoxonase 1 and 2, MTHFR and AT1R genetic variants.
Synergistic effect of MTHFR C677T and F2 G20210A polymorphisms on ischemic stroke.
Synergistic Effect of the MTHFR C677T and EPHX2 G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients.
Tagging Functional Polymorphism in 3' Untranslated Region of Methylene Tetrahydrofolate Reductase and Risk of Ischemic Stroke.
Tagging SNPs in the MTHFR gene and risk of ischemic stroke in a Chinese population.
The APOE E4 Allele Confers Increased Risk of Ischemic Stroke Among Greek Carriers.
The association of MTHFR C677T variant with increased risk of ischemic stroke in the elderly population: a meta-analysis of observational studies.
The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with idiopathic ischemic stroke in the young Mexican-Mestizo population.
The combination of homozygous MTHFR 677T and angiotensin II type-1 receptor 1166C variants confers the risk of small-vessel-associated ischemic stroke.
The effect of polymorphisms of MTHFR C677T, A1298C, MS A2756G and CBS 844ins68bp on plasma total homocysteine level and the risk of ischemic stroke in Thai children.
The factor V Leiden, prothrombin gene 20210GA, methylenetetrahydrofolate reductase 677CT and platelet glycoprotein IIIa 1565TC mutations in patients with acute ischemic stroke and atrial fibrillation.
The methylenetetrahydrofolate reductase (MTHFR) 677C-->T mutation and cardiovascular risk--A case of ischemic stroke and acute myocardial infarction.
The Methylenetetrahydrofolate Reductase C677T (rs1801133) and Apolipoprotein A5-1131T>C (rs662799) Polymorphisms, and Anemia Are Independent Risk Factors for Ischemic Stroke.
The methylenetetrahydrofolate reductase gene C677T mutant and ischemic stroke in sickle cell disease.
The Methylenetetrahydrofolate Reductase Polymorphism (MTHFR c.677C>T) and Elevated Plasma Homocysteine Levels in a U.S. Pediatric Population with Incident Thromboembolism.
The Relationship of Methylenetetrahydrofolate Reductase Gene C677T Polymorphism and Ischemic Stroke in Chinese Han Population.
The role of genetic risk factors in arterial ischemic stroke in pediatric and adult patients: a critical review.
The Role of Polymorphism Gen Methylene Tetra Hydrofolate Reductase (MTHFR) C677T in Ischaemic Stroke Patients with and Without Hypertension.
The T allele of the 677C>T polymorphism of methylenetetrahydrofolate reductase gene is associated with an increased risk of ischemic stroke in Polish children.
The TT genotype of methylenetetrahydrofolate reductase 677C>T polymorphism increases the susceptibility to pediatric ischemic stroke: meta-analysis of the 822 cases and 1,552 controls.
The U-shaped relationship between serum methylene tetrahydrofolate reductase and large-artery atherosclerotic stroke.
TT genotype of the methylenetetrahydrofolate reductase C677T polymorphism is an important determinant for homocysteine levels in multi-ethnic Malaysian ischaemic stroke patients.
[A case-control study on the relationship between stroke and plasma homocysteine level and the mutation of MTHFR gene.]
[A clinical and genetic analysis of risk factors for the development of acute and chronic cerebral ischemia].
[A comparative analysis of allele frequencies of rs1801133 and rs1801131 of MTHFR in patients with stroke and healthy people from the Moscow region].
[A role of genetic factors and related disorder of the folate cycle in ischemic stroke].
[Association study of renin-angiotensin system genes and hemostasis system genes with ischemic stroke among Russians of Central Russia].
[Genetic mutations of homocysteine metabolism related enzymes in patients with ischemic stroke.]
[Hyperhomocysteine, methylenetetrahydrofolate reductase gene, and other risk factors in ischemic stroke]
[Interactions between the MTHFR C677T and MTHFR A1298C mutations in ischaemic stroke]
[Mutations of genes associated with thromboses in ischemic stroke in patients with primary antiphospholipid syndrome]
[Prevalence of methylenetetrahydrofolate reductase C677T mutation among patients with acute ischemic cerebrovascular disease in Aragon]
[Relationship between methylenetetrahydrofolate reductase gene C677T polymorphism and susceptibility of ischemic stroke: a meta-analysis].
[Relationship between methylenetrahydrofolate reductase gene and ischemic stroke]
[Role of methyltetrahydrofolate reductase (MTHFR) gene polymorphism in the development of ischemic stroke in the dwellers of the Kyrgyz Republic].
[Study on relationship between constitution and syndrome of MMP-9, IL-6 and MTHFR gene in patients with ischemic stroke].
isovaleryl-coa dehydrogenase deficiency
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
Joint Diseases
Genetic biomarkers related to hemarthrosis, inflammation, and cartilage structure in pediatric patients with hemophilic arthropathy.
Kidney Diseases
Methionine synthase reductase MTRR 66A > G has no effect on total homocysteine, folate, and Vitamin B12 concentrations in renal transplant patients.
Methylenetetrahydrofolate reductase (MTHFR) polymorphism A1298C (Glu429Ala) predicts decline in renal function over time in the African-American Study of Kidney Disease and Hypertension (AASK) Trial and Veterans Affairs Hypertension Cohort (VAHC).
Kidney Failure, Chronic
An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease.
An unusually high plasma concentration of homocysteine resulting from a combination of so-called "secondary" etiologies.
Cerebral vascular complication and hyperhomocysteinemia in a cystinotic uremic child.
Contribution of GSTM1, GSTT1, and MTHFR polymorphisms to end-stage renal disease of unknown etiology in Mexicans.
Correlations of MTHFR 677C>T polymorphism with cardiovascular disease in patients with end-stage renal disease: a meta-analysis.
Decisive evidence corroborates a null relationship between MTHFR C677T and chronic kidney disease: A case-control study and a meta-analysis.
DNA methylation status of the methylenetetrahydrofolate reductase gene promoter in peripheral blood of end-stage renal disease patients.
Effect of MTHFR C677T genotype on survival in type 2 diabetes patients with end-stage diabetic nephropathy.
Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with advanced CKD and ESRD: a prospective study.
Hyperhomocysteinemia is related to residual glomerular filtration and folate, but not to methylenetetrahydrofolate-reductase and methionine synthase polymorphisms, in supplemented end-stage renal disease patients undergoing hemodialysis.
Hyperhomocysteinemia, diabetes mellitus, and carotid atherosclerosis independently increase atherosclerotic vascular disease outcome in Japanese patients with end-stage renal disease.
Influence of 5,10-methylenetetrahydrofolate reductase gene polymorphism on plasma homocysteine concentration in patients with end-stage renal disease.
Methylenetetrahydrofolate reductase gene C677T polymorphism, plasma homocysteine and folate in end-stage renal disease dialysis and non-dialysis patients.
Methylenetetrahydrofolate reductase gene polymorphisms in essential hypertension relation: with the development of hypertensive end-stage renal disease.
MTHFR A1298C polymorphism is associated with cardiovascular risk in end stage renal disease in North Indians.
MTHFR and HFE, but not preproghrelin and LBP, polymorphisms as risk factors for all-cause end-stage renal disease development.
Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients.
Phenotypic and genotypic risk factors for cardiovascular events in an incident dialysis cohort.
Polymorphism in methylenetetrahydrofolate reductase gene: its impact on plasma homocysteine levels and carotid atherosclerosis in ESRD patients receiving hemodialysis.
Polymorphism in methylenetetrahydrofolate reductase, plasminogen activator inhibitor-1, and apolipoprotein E in hemodialysis patients.
Prediction of susceptible biomarkers for end stage renal disease among North Indians.
Role of Thrombotic Risk Factors in End-Stage Renal Disease.
The C677T methylenetetrahydrofolate reductase gene mutation does not influence cardiovascular risk in the dialysis population: results of a multicentre prospective study.
The MTHFR 677TT and 677CT/1298AC genotypes in Cypriot patients may be predisposing to hypertensive nephrosclerosis and chronic renal failure.
Kidney Neoplasms
Comprehensive evaluation of one-carbon metabolism pathway gene variants and renal cell cancer risk.
Klinefelter Syndrome
Klinefelter's Syndrome and Venous Thrombosis.
Severe arterial thrombophilia associated with a homozygous MTHFR gene mutation (A1298C) in a young man with Klinefelter syndrome.
Laryngeal Neoplasms
Alterations in the expression pattern of MTHFR, DHFR, TYMS, and SLC19A1 genes after treatment of laryngeal cancer cells with high and low doses of methotrexate.
Association of dietary intake of folate and MTHFR genotype with breast cancer risk.
Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer.
Lateral Sinus Thrombosis
Bilateral transverse sinus thrombosis secondary to a homozygous C677T MTHFR gene mutation.
[Acute cerebral sinus-thrombosis due to polyangiitis overlap syndrome with granulomatosis with polyangiitis (Wegener's granulomatosis) and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)].
Legg-Calve-Perthes Disease
Association of MTHFR and TNF-? genes polymorphisms with susceptibility to Legg-Calve-Perthes disease in Iranian children: A case-control study.
Meta-analysis of hypercoagulability genetic polymorphisms in perthes disease.
PlA2 Polymorphism of Platelet Glycoprotein IIb/IIIa and C677T Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR), but Not Factor V Leiden and Prothrombin G20210A Polymorphisms, Are Associated with More Severe Forms of Legg-Calvé-Perthes Disease.
Leiomyoma
Correlation Analysis Between MTHFR C677T Polymorphism and Uterine Fibroids: A Retrospective Cohort Study.
Lemierre Syndrome
Lemierre's syndrome with double heterozygote status in the methylenetetrahydrofolate reductase gene.
Lens Subluxation
CBS mutations and MTFHR SNPs causative of hyperhomocysteinemia in Pakistani children.
Homocysteinemia due to MTHFR deficiency in a young adult presenting with bilateral lens subluxations.
Leukemia
5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview.
A duplex polymerase chain reaction-restriction fragment length polymorphism for rapid screening of methylenetetrahydrofolate reductase gene variants: Genotyping in acute leukemia.
Association between the MTHFR A1298C polymorphism and increased risk of acute myeloid leukemia in Brazilian children.
Association of drug metabolism gene polymorphisms with toxicities, graft-versus-host disease and survival after HLA-identical sibling hematopoietic stem cell transplantation for patients with leukemia.
Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.
Association of MTHFR polymorphisms and chromosomal abnormalities in leukemia.
Association of the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) polymorphisms in Korean patients with adult acute lymphoblastic leukemia.
Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia.
Deregulation of folate pathway gene expression correlates with poor prognosis in acute leukemia.
Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE).
Genetic predisposition and treatment-related leukemia.
Genetic susceptibility to cancer: the role of polymorphisms in candidate genes.
Genotyping of the MTHFR gene polymorphism, C677T in patients with leukemia by melting curve analysis.
Maternal and offspring genetic variants of AKR1C3 and the risk of childhood leukemia.
Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations.
Methotrexate-induced mucositis in acute leukemia patients is not associated with the MTHFR 677T allele in Mexico.
Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia.
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia.
Methylenetetrahydrofolate reductase and glutathione s-tranferase gene polymorphisms in secondary mixed phenotype acute leukemia: a case report.
Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphisms: association with risk for pediatric acute lymphoblastic leukemia in north Indians.
MTHFR 677CC/1298CC genotypes are highly associated with chronic myelogenous leukemia: a case-control study in Korea.
MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: A meta-analysis.
MTHFR Gene Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Adults and Children: A Case Control Study in India.
MTHFR polymorphisms and the development of acute leukemia: does it really matter?
MTHFR single nucleotide polymorphism associated with working memory in pediatric medulloblastoma survivors.
No evidence of association of methylenetetrahydrofolate reductase polymorphism with occurrence of second neoplasms after treatment of childhood leukemia.
Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults.
Polymorphisms involved in folate metabolism pathways and the risk of the development of childhood acute leukemia.
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase, dietary folate intake, and the risk of leukemia in adults.
Preponderance of methylenetetrahydrofolate reductase C677T homozygosity among leukemia patients intolerant to methotrexate.
Role of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies.
Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.
The association of methylenetetrahydrofolate reductase genotypes with the risk of childhood leukemia in Taiwan.
The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans.
The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia.
The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population.
Thiopurine S-Methyltransferase and Methylenetetrahydrofolate Reductase Polymorphisms in Leukemia.
[Detection of Single Nucleotide Polymorphisms of mthfr and dpyd Genes in Leukemia Cell Lines K562 and K562/A02.]
Leukemia, Lymphocytic, Chronic, B-Cell
Association of MTHFR C677T and A1298C Polymorphisms with Susceptibility to Chronic Lymphocytic Leukemia: A Systematic Review and Meta-Analysis.
Methylenetetrahydrofolate reductase (MTHFR) gene 677C>T and 1298A>C polymorphisms are associated with differential apoptosis of leukemic B cells in vitro and disease progression in chronic lymphocytic leukemia.
MTHFR polymorphisms and risk of chronic lymphocytic leukemia.
The influence of MTHFR C677T polymorphism in chronic lymphocytic leukemia.
Leukemia, Lymphoid
5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Association between methylene tetrahydrofolate reductase and glutathione S-transferase M1 gene polymorphisms and chronic myeloid leukemia in a Brazilian population.
Association between methylenetetrahydrofolate reductase polymorphism C677T and risk of chronic myeloid leukemia in Serbian population.
Chronic Myeloid Leukemia with b3a3 (e14a3) Fusion: A Rare BCR/ABL Rearrangement Presenting with Thrombocytosis - Does MTHFR Polymorphism Matter.
Genotyping of the MTHFR gene polymorphism, C677T in patients with leukemia by melting curve analysis.
Haplotype analysis of the C677T and A1298C polymorphisms of MTHFR and susceptibility to chronic myeloid leukemia.
Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations.
Methylenetetrahydrofolate reductase and thymidylate synthase genotypes and risk of acute graft-versus-host disease following hematopoietic cell transplantation for chronic myelogenous leukemia.
Methylenetetrahydrofolate Reductase Gene C677T and A1298C Polymorphic Sequence Variations Influences the Susceptibility to Chronic Myeloid Leukemia in Kashmiri Population.
Methylenetetrahydrofolate reductase gene polymorphism and risk of chronic myelogenous leukemia: a meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphisms contribute to acute myeloid leukemia and chronic myeloid leukemia susceptibilities: appraisal of a recent meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphisms contribute to acute myeloid leukemia and chronic myeloid leukemia susceptibilities: evidence from meta-analyses.
Methylenetetrahydrofolate reductase genotype affects risk of relapse after hematopoietic cell transplantation for chronic myelogenous leukemia.
MTHFR 677CC/1298CC genotypes are highly associated with chronic myelogenous leukemia: a case-control study in Korea.
MTHFR A1298C and C677T gene polymorphisms and susceptibility to chronic myeloid leukemia in Egypt.
MTHFR genetic polymorphisms may contribute to the risk of chronic myelogenous leukemia in adults: a meta-analysis of 12 genetic association studies.
The methylenetetrahydrofolate reductase (MTHFR) 677 C>T polymorphism increases the risk of developing chronic myeloid leukemia-a case-control study.
[PROVISIONAL] The differential effects of the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) on hematological malignancies among Latinos: a meta-analysis.
Leukemia, Myeloid
Genotyping of the MTHFR gene polymorphism, C677T in patients with leukemia by melting curve analysis.
MTHFR gene polymorphism and risk of myeloid leukemia: a meta-analysis.
Leukemia, Myeloid, Acute
Association between MTHFR polymorphisms and acute myeloid leukemia risk: a meta-analysis.
Association between the MTHFR A1298C polymorphism and increased risk of acute myeloid leukemia in Brazilian children.
Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia.
Genetic variation in the folate metabolic pathway and risk of childhood leukemia.
Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations.
Methylenetetrahydrofolate reductase 677 C> T polymorphism is associated with acute myeloid leukemia.
Methylenetetrahydrofolate reductase gene polymorphisms contribute to acute myeloid leukemia and chronic myeloid leukemia susceptibilities: appraisal of a recent meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphisms contribute to acute myeloid leukemia and chronic myeloid leukemia susceptibilities: evidence from meta-analyses.
MTHFR 677C-->T and 1298A-->C polymorphisms in children with Down syndrome and acute myeloid leukemia in Brazil.
Polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) are associated with susceptibility to adult acute myeloid leukemia in a Chinese population.
Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults.
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase, dietary folate intake, and the risk of leukemia in adults.
The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia.
[A new method for 5, 10-methylenetetrahydrofolate reductase single nucleotide polymorphisms genotyping used to study susceptibility of hematological malignancy]
[Association of single nucleotide polymorphism of methylenetetrahydrofolate reductase gene with susceptibility to acute leukemia].
[PROVISIONAL] The differential effects of the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) on hematological malignancies among Latinos: a meta-analysis.
Leukoencephalopathies
Acute leukoencephalopathy possibly induced by phenytoin intoxication in an adult patient with methylenetetrahydrofolate reductase deficiency.
Intermittent encephalopathy, reversible nerve conduction slowing, and MRI evidence of cerebral white matter disease in methylenetetrahydrofolate reductase deficiency.
Methylenetetrahydrofolate Reductase Deficiency as a Cause of Treatable Adult-onset Leukoencephalopathy and Myelopathy.
MTHFR Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and Dementia.
Posterior-predominant leukoencephalopathy which was caused by methylenetetrahydrofolate reductase deficiency and successfully treated with folic acid.
Rapidly progressive psychotic symptoms triggered by infection in a patient with methylenetetrahydrofolate reductase deficiency: a case report.
Reversible leukoencephalopathy and cerebral atrophy in Homocystinuria due to MTHFR deficiency: A treatable metabolic disorder.
Leukopenia
Correlation Between Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphisms and Pemetrexed Chemotherapy Efficacy/Toxicity in Non-Squamous Non-Small Cell Lung Cancer.
Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival.
Gene-Gene Interactions of Gemcitabine Metabolizing-Enzyme Genes hCNT3 and WEE1 for Preventing Severe Gemcitabine-Induced Hematological Toxicity.
High dose methotrexate treatment in childhood ALL: pilot study on the impact of the MTHFR 677C>T and 1298A>C polymorphisms on MTX-related toxicity.
Methotrexate-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses.
Methylenetetrahydrofolate reductase gene haplotypes affect toxicity during maintenance therapy for childhood acute lymphoblastic leukemia in Japanese patients.
Pharmacogenetic studies in children with acute lymphoblastic leukemia in Argentina.
Lichen Planus
Studying the association between methylenetetrahydrofolate reductase (MTHFR) 677 gene polymorphism, cardiovascular risk and lichen planus.
Lichen Planus, Oral
Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk.
Livedo Reticularis
Cerebral Venous Thrombosis and Livedo Reticularis in a Case with MTHFR 677TT Homozygote.
Livedoid Vasculopathy
Livedoid vasculopathy and hypercoagulability in a patient with primary Sjögren's syndrome.
Livedoid vasculopathy associated with combined prothrombin G20210A and factor V (Leiden) heterozygosity and MTHFR C677T homozygosity.
Livedoid vasculopathy in a patient with lupus anticoagulant and MTHFR mutation: treatment with low-molecular-weight heparin.
Polymorphisms of MTHFR gene associated with livedoid vasculopathy in Taiwanese population.
Liver Cirrhosis
Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics.
Hyperhomocysteinemia and MTHFR C677T polymorphism in patients with portal vein thrombosis complicating liver cirrhosis.
Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients.
Methylenetetrahydrofolate reductase C677T polymorphism and liver fibrosis progression in patients with recurrent hepatitis C.
Methylenetetrahydrofolate reductase homozygosis and low-density lipoproteins in patients with genotype 1 chronic hepatitis C.
MTHFR C677T mutations in liver cirrhosis with and without portal vein thrombosis.
MTHFR C677T polymorphism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption.
MTHFR C677TT, PAI1 4G-4G, V Leiden Q506, and prothrombin G20210A in hepatocellular carcinoma with and without portal vein thrombosis.
MTHFR rs1801133 Polymorphism Is Associated With Liver Fibrosis Progression in Chronic Hepatitis C: A Retrospective Study.
PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis.
Portal vein thrombosis in Egyptian patients with liver cirrhosis: Role of methylenetetrahydrofolate reductase C677T gene mutation.
Possible Association Between the Methylenetetrahydrofolate Reductase Gene C677T Polymorphism and Preexisting Portal Vein Thrombosis in Liver Transplant Recipients.
Thrombophilic genetic factors PAI-1 4G-4G and MTHFR 677TT as risk factors of alcohol, cryptogenic liver cirrhosis and portal vein thrombosis, in a Caucasian population.
[Mathematic Model for Prediction of Liver Fibrosis Progression Rate in Patients with Chronic Hepatitis C Based on Combination of Genomic Markers].
[The relationship between the plasma homocysteine level and the polymorphism of MTHFR gene C667T in liver cirrhosis]
Liver Cirrhosis, Alcoholic
The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis.
Liver Diseases
Alanine amino transferase concentrations are linked to folate intakes and methylenetetrahydrofolate reductase polymorphism in obese adolescent girls.
Associations between Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms and Non-Alcoholic Fatty Liver Disease (NAFLD) Risk: A Meta-Analysis.
Genetic variants in the MTHFR are not associated with fatty liver disease.
Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics.
Methylenetetrahydrofolate reductase C677T mutation and nonalcoholic fatty liver disease.
Methylenetetrahydrofolate Reductase Gene Polymorphism and Serum Homocysteine Levels in Nonalcoholic Fatty Liver Disease.
Mild Methylenetetrahydrofolate Reductase Deficiency Alters Inflammatory and Lipid Pathways in Liver.
MTHFR 677C/T and 1298A/C mutations and non-alcoholic fatty liver disease.
MTHFR C677T polymorphism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption.
MTHFR rs1801133 Polymorphism Is Associated With Liver Fibrosis Progression in Chronic Hepatitis C: A Retrospective Study.
Non-alcoholic fatty liver disease (NAFLD) and MTHFR 1298A > C gene polymorphism.
The methylenetetrahydrofolate reductase genotype 677CT and non-alcoholic fatty liver disease have a synergistic effect on the increasing homocysteine levels in subjects from Chongqing, China.
[C677T AND A1298C ALLELE POLYMORPHISM GENE OF METHYLENETETRAHYDRAFOLATEREDUCTASE IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE AND TYPE 2 DIABETES].
Liver Diseases, Alcoholic
MTHFR C677T polymorphism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption.
Liver Neoplasms
Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies.
Associations between MTHFR Ala222Val polymorphism and risks of hepatitis and hepatitis-related liver cancer: a meta-analysis.
Folate metabolism-related gene polymorphisms and susceptibility to primary liver cancer in North China.
Metabolomic study of the intervention effects of Shuihonghuazi Formula, a Traditional Chinese Medicinal formulae, on hepatocellular carcinoma (HCC) rats using performance HPLC/ESI-TOF-MS.
Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population.
Quantitative assessment of the association between MTHFR rs1801131 polymorphism and risk of liver cancer.
Single nucleotide polymorphisms of one-carbon metabolism and cancers of the esophagus, stomach, and liver in a Chinese population.
The RFC1 80G>A, among Common One-Carbon Polymorphisms, Relates to Survival Rate According to DNA Global Methylation in Primary Liver Cancers.
long-chain acyl-coa dehydrogenase deficiency
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
long-chain-3-hydroxyacyl-coa dehydrogenase deficiency
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
Low Tension Glaucoma
Plasma homocysteine, MTHFR gene mutation, and open-angle glaucoma.
Lung Neoplasms
A methylenetetrahydrofolate reductase polymorphism is associated with expression of p16 in human lung cancer.
A single-nucleotide polymorphism in the MTHFR (methylene tetrahydrofolate reductase) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy.
Advances in cancer epidemiology in Japan.
Allele and Genotype Frequencies of the Polymorphic Methylenetetrahydrofolate Reductase and Lung Cancer in ther Jordanian Population: a Case Control Study.
Association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and lung cancer risk in Chinese people: An updated meta-analysis.
Association of deep venous thrombosis with prothrombotic gene polymorphism identified in lung cancer cases.
Association of polymorphisms in one-carbon metabolizing genes and lung cancer risk: a case-control study in Chinese population.
Combined Effect of MTHFR C677T and PAI-1 4G/5G Polymorphisms on the Risk of Venous Thromboembolism in Chinese Lung Cancer Patients.
Correlation Between Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphisms and Pemetrexed Chemotherapy Efficacy/Toxicity in Non-Squamous Non-Small Cell Lung Cancer.
Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes.
Effect of alcohol and its metabolites in lung cancer: CAPUA study.
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on patients with cisplatin/gemcitabine-treated stage IV non-small-cell lung cancer.
Folate pathway gene MTHFR C677T polymorphism and risk of lung cancer in Asian populations.
Folate-related genes and the risk of tobacco-related cancers in Central Europe.
Genetic Polymorphisms and Platinum-Based Chemotherapy-Induced Toxicities in Patients With Lung Cancer: A Systematic Review and Meta-Analysis.
Heterozygote advantage of methylenetetrahydrofolate reductase polymorphisms on clinical outcomes in advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy.
Hierarchical clustering of lung cancer cell lines using DNA methylation markers.
Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study.
Influence of methylenetetrahydrofolate reductase C677T polymorphism on the risk of lung cancer and the clinical response to platinum-based chemotherapy for advanced non-small cell lung cancer: an updated meta-analysis.
Influence of polymorphisms in MTHFR 677 C?T, TYMS 3R?2R and MTR 2756 A?G on NSCLC risk and response to platinum-based chemotherapy in advanced NSCLC.
Interaction of methylenetetrahydrofolate reductase genotype and smoking habit in Taiwanese lung cancer patients.
Lack of association between the MTHFRC677T polymorphism and lung cancer in a Turkish population.
Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer.
Meta-analysis of methylenetetrahydrofolate reductase polymorphism and lung cancer risk in Chinese.
Meta-analysis on MTHFR polymorphism and lung cancer susceptibility in East Asian populations.
Methylenetetrahydrofolate reductase 677TT genotype may be associated with an increased lung cancer risk in North China: an updated meta-analysis.
Methylenetetrahydrofolate reductase 677TT genotype might be associated with an increased lung cancer risk in Asians.
Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean population.
Methylenetetrahydrofolate reductase C677T polymorphism predicts response and time to progression to gemcitabine-based chemotherapy for advanced non-small cell lung cancer in a Chinese Han population.
Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer.
Methylenetetrahydrofolate Reductase Gene C677T Polymorphism and Lung Cancer: an Updated Meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis.
Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese population.
MTHFR C667T Polymorphism Association with Lung Cancer Risk in Henan Province: A Case-control Study.
MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population.
MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation.
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China.
Polymorphisms in thymidylate synthase and reduced folate carrier (SLC19A1) genes predict survival outcome in advanced non-small cell lung cancer patients treated with pemetrexed-based chemotherapy.
Polymorphisms of methylene-tetrahydrofolate reductase and risk of lung cancer: a case-control study.
Predicting chemosensitivity to gemcitabine and cisplatin based on gene polymorphisms and mRNA expression in non-small-cell lung cancer cells.
Prognostic significance of the polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase gene in lung cancer.
Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors.
Quantitative assessment of the effect of MTHFR polymorphisms on the risk of lung carcinoma.
Serum folate concentration and the incidence of lung cancer.
Sex differences in risk of lung cancer associated with methylene-tetrahydrofolate reductase polymorphisms.
The association between methylene-tetrahydrofolate reductase gene polymorphism and lung cancer risk.
The association between methylenetetrahydrofolate reductase 677C>T polymorphisms and breast cancer susceptibility: A meta-analysis based on Chinese Han population.
The influence of methylenetetrahydrofolate reductase and thymidylate synthetase gene polymorphisms on lung adenocarcinoma occurrence.
The methylenetetrahydrofolate reductase 677C-->T polymorphism and lung cancer risk in a Chinese population.
Variants in folate pathway genes as modulators of genetic instability and lung cancer risk.
[Association between genetic polymorphisms in methylentetrahydrofolate reductase and risk of lung cancer]
[Genetic polymorphisms in methylenetetrahydrofolate reductase and clinical response to chemotherapy in non-small cell lung cancer.]
Lupus Erythematosus, Systemic
Homocysteine, methylenetetrahydrofolate reductase polymorphism, antiphospholipid antibodies, and thromboembolic events in systemic lupus erythematosus: a retrospective cohort study.
Longitudinal myelitis in patient with systemic lupus erythematosus, homozygous prothrombin G20210A and heterozygous MTHFR 677T.
MTHFR polymorphisms (rs1801133) and systemic lupus erythematosus risk: A meta-analysis.
The 677C --> T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in epileptic patients affected by systemic lupus erythematosus.
The Association of MTHFR C677T and MTR A2756G Gene Polymorphisms With the Risk of Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis.
[Prognostic value of allelic variants affecting the hemostatic system in the development of antiphospholipid syndrome and kidney lesion in patients with systemic lupus erythematosus].
Lyme Disease
Unilateral sequential papillophlebitis and central retinal artery occlusion in a young healthy patient.
Lymphatic Metastasis
The 677C > T mutation in 5,10-methylenetetrahydrofolate reductase and colorectal cancer risk.
Lymphoma
Association between the MTHFR A1298C polymorphism and risk of cancer: evidence from 265 case-control studies.
Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma.
Association of MTHFR and ABCB1 polymorphisms with MTX-induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma-A retrospective cohort study.
Association of the methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia.
Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia or lymphoma.
Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East.
Genetic polymorphisms predicting methotrexate blood levels and toxicity in adult non-Hodgkin lymphoma.
High resolution array comparative genomic hybridization identifies copy number alterations in diffuse large B-cell lymphoma that predict response to immuno-chemotherapy.
Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma.
Methotrexate elimination and toxicity: MTHFR 677C>T polymorphism in patients with primary CNS lymphoma treated with high-dose methotrexate.
Methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms and reduced risk of malignant lymphoma.
Methylenetetrahydrofolate reductase gene polymorphisms association with the risk of diffuse large B cell lymphoma: a meta-analysis.
Methylenetetrahydrofolate reductase genotype does not play a role in adult T-cell leukemia/lymphoma pathogenesis among human T-lymphotrophic virus type 1 carriers.
Methylenetetrahydrofolate reductase genotype in diffuse large B-cell lymphomas with and without hypermethylation of the DNA repair gene O6-methylguanine DNA methyltransferase.
MTHFR gene variants and non-MALT lymphoma development in primary Sjogren's syndrome.
Lymphoma, B-Cell
Association between folate-metabolizing pathway polymorphism and non-Hodgkin lymphoma.
Genetic and epigenetic variants in the MTHFR gene are not associated with non-Hodgkin lymphoma.
Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East.
Influence of MTHFR C677T Polymorphism on High-Dose Methotrexate-Related Toxicity in Patients With Primary Central Nervous System Diffuse Large B-Cell Lymphoma.
Methylenetetrahydrofolate reductase gene polymorphisms association with the risk of diffuse large B cell lymphoma: a meta-analysis.
Methylenetetrahydrofolate reductase genotype in diffuse large B-cell lymphomas with and without hypermethylation of the DNA repair gene O6-methylguanine DNA methyltransferase.
The importance of negative results: methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in diffuse large B-cell lymphomas (DLBCL).
Lymphoma, Follicular
Methylenetetrahydrofolate reductase gene polymorphisms association with the risk of follicular lymphoma: a meta-analysis.
Methylenetetrahydrofolate reductase genotype association with the risk of follicular lymphoma.
Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma.
Lymphoma, Large B-Cell, Diffuse
Association between folate-metabolizing pathway polymorphism and non-Hodgkin lymphoma.
Genetic and epigenetic variants in the MTHFR gene are not associated with non-Hodgkin lymphoma.
Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East.
Influence of MTHFR C677T Polymorphism on High-Dose Methotrexate-Related Toxicity in Patients With Primary Central Nervous System Diffuse Large B-Cell Lymphoma.
Methylenetetrahydrofolate reductase gene polymorphisms association with the risk of diffuse large B cell lymphoma: a meta-analysis.
Lymphoma, Non-Hodgkin
Association of MTHFR C677T and A1298C polymorphisms with non-Hodgkin lymphoma susceptibility: evidence from a meta-analysis.
Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults.
Genetic and epigenetic variants in the MTHFR gene are not associated with non-Hodgkin lymphoma.
Granulomatous reaction in mediastinal B-cell non-Hodgkin lymphoma and intracardiac thrombosis.
Influence of Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphism on High-Dose Methotrexate-Related Toxicities in Pediatric Non-Hodgkin Lymphoma Patients.
Influence of MTHFR C677T and A1298C polymorphisms on the survival of pediatric patients with non-Hodgkin lymphoma.
Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin's lymphoma or multiple myeloma.
Methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and risk of pediatric non-Hodgkin lymphoma in a German study population.
Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma.
Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: association with toxicity and survival.
Methylenetetrahydrofolate reductase gene polymorphisms (677C > T and 1298A > C) in Egyptian patients with non-Hodgkin lymphoma.
MTHFR 677 (C-->T) polymorphism is not relevant for prognosis or therapy-associated toxicity in pediatric NHL: results from 484 patients of multicenter trial NHL-BFM 95.
Polymorphisms in folate-metabolizing genes and risk of non-Hodgkin's lymphoma.
Polymorphisms in methylenetetrahydrofolate reductase gene and risk of non-Hodgkin lymphoma in a multi-ethnic population.
The Influence of MTHFR Gene Polymorphisms on the Outcome of Pediatric Non-Hodgkin Lymphoma Patients Treated with High-Dose Methotrexate.
[A new method for 5, 10-methylenetetrahydrofolate reductase single nucleotide polymorphisms genotyping used to study susceptibility of hematological malignancy]
Lymphoma, T-Cell
Association between folate-metabolizing pathway polymorphism and non-Hodgkin lymphoma.
Lymphoproliferative Disorders
Methylenetetrahydrofolate reductase C677T polymorphism in adult patients with lymphoproliferative disorders and its effect on chemotherapy.
Normal frequencies of the C677T genotypes on the methylenetetrahydrofolate reductase (MTHFR) gene among lymphoproliferative disorders but not in multiple myeloma.
Macular Degeneration
Homocysteine, B Vitamins, MTHFR Genotype, and Incident Age-related Macular Degeneration.
Impact of methylenetetrahydrofolate reductase C677T polymorphism on the efficacy of photodynamic therapy in patients with neovascular age-related macular degeneration.
Predictive role of C677T MTHFR polymorphism in variable efficacy of photodynamic therapy for neovascular age-related macular degeneration.
Malaria
Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2).
Increased Resistance to Malaria in Mice with Methylenetetrahydrofolate Reductase (Mthfr) Deficiency Suggests a Mechanism for Selection of the MTHFR 677C>T (c.665C>T) Variant.
Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India.
Malaria, Cerebral
Increased Resistance to Malaria in Mice with Methylenetetrahydrofolate Reductase (Mthfr) Deficiency Suggests a Mechanism for Selection of the MTHFR 677C>T (c.665C>T) Variant.
Malnutrition
Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease.
Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: The A1298C polymorphism does matter. Inferences from a case study (Madeira, Portugal).
MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring.
Vascular and cellular stress in inflammatory bowel disease: revisiting the role of homocysteine.
Mania
A prospective study to explore the relationship between MTHFR C677T genotype, physiological folate levels, and postpartum psychopathology in at-risk women.
Maple Syrup Urine Disease
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
Marfan Syndrome
Phenotypic variability of cardiovascular manifestations in Marfan Syndrome. Possible role of hyperhomocysteinemia and C677T MTHFR gene polymorphism.
Mastitis
Relationship between granulomatous lobular mastitis and methylene tetrahydrofolate reductase gene polymorphism.
medium-chain acyl-coa dehydrogenase deficiency
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
Medulloblastoma
MTHFR single nucleotide polymorphism associated with working memory in pediatric medulloblastoma survivors.
Melanoma
Polymorphisms in the MTHFR and VDR genes and skin cancer risk.
Memory Disorders
Epigenetic Factors in Late-Onset Alzheimer's Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B Vitamins.
High homocysteine and epistasis between MTHFR and APOE: association with cognitive performance in the elderly.
MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring.
Meningioma
5,10-Methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) gene polymorphisms and adult meningioma risk.
Association of MTHFR, MTRR and RAD54L Gene Variations with Meningioma and Correlation with Tumor's Histopathological Characteristics on Turkish Cohort.
Association of Single Nucleotide Polymorphisms (SNPs) in Genes Encoding for Folate Metabolising Enzymes with Glioma and Meningioma in Indian Population
Association of the MTHFR C677T polymorphism with primary brain tumor risk.
Association study on MTHFR polymorphisms and meningioma in northern China.
C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and high-grade gliomas.
Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults.
Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma.
Genetic variants and increased risk of meningioma: an updated meta-analysis.
Risk association of meningiomas with MTHFR C677T and GSTs polymorphisms: a meta-analysis.
Meningomyelocele
Deep sequencing study of the MTHFR gene to identify variants associated with myelomeningocele.
Folate metabolism gene 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with ADHD in myelomeningocele patients.
Homocysteine, folate, lipid profile and MTHFR genotype and disability in children with myelomeningocele.
No evidence for heterozygote advantage at MTHFR in patients with lumbosacral myelomeningocele or their relatives.
Possible interaction of genotypes at cystathionine beta-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects. NTD Collaborative Group.
The effect of C677T mutation of methylene tetrahydrofolate reductase gene and plasma folate level on hyperhomocysteinemia in patients with meningomyelocele.
Menkes Kinky Hair Syndrome
Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.
Mesenteric Ischemia
Combined portal, splenic and mesenteric venous thrombosis in inactive ulcerative colitis with heterozygous mutation in MTHFR gene: A rare case of thrombophilia.
Heterozygous prothrombin 20210G/A mutation, associated with hyperhomocysteinemia, and homozygous methylenetetrahydrofolate reductase 677C/T mutation, in a patient with portal and mesenteric venous thrombosis.
Mesenteric venous thrombosis with bowel infarction and hyperhomocysteinemia due to homozygous methylenetetrahydrofolate reductase C677T genotype.
Mesothelioma
Correlation between TS, MTHFR, and ERCC1 gene polymorphisms and the efficacy of platinum in combination with pemetrexed first-line chemotherapy in mesothelioma patients.
Metabolic Syndrome
A Genetic Association Study of MTHFR C677T Polymorphism with Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis.
Association between folate metabolism-related polymorphisms and colorectal cancer risk.
Association Between Polymorphisms in MTHFR and APOA5 and Metabolic Syndrome in the Greek Population.
Association of FTO, LEPR and MTHFR gene polymorphisms with metabolic syndrome in schizophrenia patients receiving antipsychotics.
Association of homocysteinemia with high concentrations of serum insulin and uric acid in Brazilian subjects with metabolic syndrome genotyped for C677T polymorphism in the methylenetetrahydrofolate reductase gene.
Association of Methylenetetrahydrofolate Reductase (MTHFR) A1298C Polymorphism with Lower High-Density Lipoprotein Cholesterol Level.
Association of MTHFR C677T gene polymorphism with metabolic syndrome in a Chinese population: a case-control study.
Association of uricemia with biochemical and dietary factors in human adults with metabolic syndrome genotyped to C677T polymorphism in the methylenetetrahydrofolate reductase gene.
Associations of MTHFR C677T and MTRR A66G gene polymorphisms with metabolic syndrome: a case-control study in Northern China.
C677T gene polymorphism of MTHFR and metabolic syndrome: response to dietary intervention.
Cyclic supplementation of 5-MTHF is effective for the correction of hyperhomocysteinemia.
Detection of metabolic syndrome in schizophrenia and implications for antipsychotic therapy : is there a role for folate?
Gene-environment interactions between methylenetetrahydrofolate reductase (MTHFR) 677C>T and metabolic syndrome for the prevalence of ischemic stroke in Koreans.
Hyperhomocysteinemia and homozygous MTHFR 677C>T mutation finding in an Alzheimer's disease case with metabolic syndrome diagnosis.
Investigation of potential biomarkers for thrombosis related diseases in Turkish Cypriot population.
Is there an association between the development of metabolic syndrome in PCOS patients and the C677T MTHFR gene polymorphism?
Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants.
MTHFR and risk of metabolic syndrome in patients with schizophrenia.
Polymorphisms of genes for brain-derived neurotrophic factor, methylenetetrahydrofolate reductase, tyrosine hydroxylase, and endothelial nitric oxide synthase in depression and metabolic syndrome.
Relationship between Metabolic Syndrome and MTHFR Polymorphism in Colorectal Cancer.
Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogenetics.
[Remodeling of the cardiovascular system and development of chronic kidney disease in patients with metabolic syndrome and obesity: role of eNOS, subunit p22-phox of NADPH-oxidase and MTHFR genes].
Metabolism, Inborn Errors
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
methionine adenosyltransferase deficiency
Reversible leukoencephalopathy with acute neurological deterioration and permanent residua in classical homocystinuria: A case report.
methionine synthase deficiency
Comparison of folic acid coenzyme distribution patterns in patients with methylenetetrahydrofolate reductase and methionine synthetase deficiencies.
Methionine and serine formation in control and mutant human cultured fibroblasts: evidence for methyl trapping and characterization of remethylation defects.
Methionine synthase deficiency without megaloblastic anaemia.
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
methylenetetrahydrofolate dehydrogenase (nad+) deficiency
5,10-Methylenetetrahydrofolate reductase (MTHFR) assay in the forward direction: residual activity in MTHFR deficiency.
5,10-Methylenetetrahydrofolate reductase deficiency with progressive polyneuropathy in an infant.
A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke.
A Novel Homozygous Non-sense Mutation in the Catalytic Domain of MTHFR Causes Severe 5,10-Methylenetetrahydrofolate Reductase Deficiency.
A rationale for cystine supplementation in severe homocystinuria.
Acquired and inherited disorders of cobalamin and folate in children.
Acute leukoencephalopathy possibly induced by phenytoin intoxication in an adult patient with methylenetetrahydrofolate reductase deficiency.
Adolescence/adult onset MTHFR deficiency may manifest as isolated and treatable distinct neuro-psychiatric syndromes.
Adolescent/adult-onset homocysteine remethylation disorders characterized by gait disturbance with/without psychiatric symptoms and cognitive decline: a series of seven cases.
Adult-onset methylenetetrahydrofolate reductase deficiency.
Adult-onset severe methylenetetrahydrofolate reductase deficiency characterized by reversible spastic paraplegia with a novel mutation.
Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice.
An early onset form of methylenetetrahydrofolate reductase deficiency: a report of a family from Kuwait.
Anesthesia for cesarean section in a patient with placenta previa and methylenetetrahydrofolate reductase deficiency.
B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke.
Betaine for treatment of homocystinuria caused by methylenetetrahydrofolate reductase deficiency.
Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.
Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia.
Characterization of a pseudogene for murine methylenetetrahydrofolate reductase.
Characterization of mutations in severe methylenetetrahydrofolate reductase deficiency reveals an FAD-responsive mutation.
Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria.
Clinical and molecular characterization of adult patients with late-onset MTHFR deficiency.
Clinical pattern, mutations and in vitro residual activity in 33 patients with severe 5, 10 methylenetetrahydrofolate reductase (MTHFR) deficiency.
Clinical presentation of seven patients with Methylenetetrahydrofolate reductase deficiency.
Clinical, fluorine-18 labeled 2-fluoro-2-deoxyglucose positron emission tomography of the brain, MR spectroscopy, and therapeutic attempts in methylenetetrahydrofolate reductase deficiency.
Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes.
Congenital errors of folate metabolism.
Congenital MTHFR deficiency causing early-onset cerebral stroke in a case homozygous for MTHFR thermolabile variant.
Defects in homocysteine metabolism: diversity among hyperhomocyst(e)inemias.
Detection of homozygotes and heterozygotes with methylenetetrahydrofolate reductase deficiency.
Determination of CSF 5-methyltetrahydrofolate in children and its application for defects of folate transport and metabolism.
Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.
Diffuse multicystic encephalomalacia in a preterm baby due to homozygous methylenetetrahydrofolate reductase 677 C-->T mutation.
Disorders of intermediary metabolism: toxic leukoencephalopathies.
Disturbed One-Carbon Metabolism Causing Adverse Reproductive Outcomes in Mice Is Associated with Altered Expression of Apolipoprotein AI and Inflammatory Mediators PPAR?, Interferon-?, and Interleukin-10.
Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.
Early treatment using betaine and methionine for a neonate with MTHFR deficiency.
Effect of betaine on S-adenosylmethionine levels in the cerebrospinal fluid in a patient with methylenetetrahydrofolate reductase deficiency and peripheral neuropathy.
Epidemiology of rare diseases detected by newborn screening in the Czech Republic.
Erratum to: Treatment with Mefolinate (5-Methyltetrahydrofolate), but Not Folic Acid or Folinic Acid, Leads to Measurable 5-Methyltetrahydrofolate in Cerebrospinal Fluid in Methylenetetrahydrofolate Reductase Deficiency.
Ethnogeographic prevalence and implications of the 677C>T and 1298A>C MTHFR polymorphisms in US primary care populations.
Expanded carrier screening in gamete donors of Venezuela.
Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate.
Folic acid nonresponsive homocystinuria due to methylenetetrahydrofolate reductase deficiency.
Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae.
Functional characterization of missense mutations in severe methylenetetrahydrofolate reductase deficiency using a human expression system.
Gender-specific effect of Mthfr genotype and neonatal vigabatrin interaction on synaptic proteins in mouse cortex.
Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)
General anesthesia and methylenetetrahydrofolate reductase deficiency.
Genome-wide Hypomethylation in Human Glioblastomas Associated with Specific Copy Number Alteration, Methylenetetrahydrofolate Reductase Allele Status, and Increased Proliferation.
Genomic structure and transcript variants of the human methylenetetrahydrofolate reductase gene.
Glutamatergic synapse protein composition of wild-type mice is sensitive to in utero MTHFR genotype and the timing of neonatal vigabatrin exposure.
Guidelines for diagnosis and management of the cobalamin-related remethylation disorders cblC, cblD, cblE, cblF, cblG, cblJ and MTHFR deficiency.
High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.
High intake of folic acid disrupts embryonic development in mice.
Homocysteinemia due to MTHFR deficiency in a young adult presenting with bilateral lens subluxations.
Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification.
Hydrocephalus internus in two patients with 5,10-methylenetetrahydrofolate reductase deficiency.
Hyperhomocysteinaemia and associated disease.
Hyperhomocysteinemia and arterial aneurysm.
Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency.
Identification and origin of N?-homocysteinyl-lysine isopeptide in humans and mice.
Identification of four novel mutations in severe methylenetetrahydrofolate reductase deficiency.
Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain.
Impact of methylenetetrahydrofolate reductase deficiency and low dietary folate on the development of neural tube defects in splotch mice.
Increased neurotoxicity of arsenic in methylenetetrahydrofolate reductase deficiency.
Increased Resistance to Malaria in Mice with Methylenetetrahydrofolate Reductase (Mthfr) Deficiency Suggests a Mechanism for Selection of the MTHFR 677C>T (c.665C>T) Variant.
Increased susceptibility to mild neonatal stress in MTHFR deficient mice.
Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation.
Insidious peripheral neuropathy occurring under treatment in infantile MTHFR deficiency.
Intermediate hyperhomocysteinaemia and compound heterozygosity for the common variant c.677C>T and a MTHFR gene mutation.
Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylenetetrahydrofolate reductase mutations.
Intermittent encephalopathy, reversible nerve conduction slowing, and MRI evidence of cerebral white matter disease in methylenetetrahydrofolate reductase deficiency.
Intrauterine vascular deficiency secondary to methylenetetrahydrofolate reductase deficiency: 2 case reports.
Isolated remethylation disorders: do our treatments benefit patients?
Life-threatening methylenetetrahydrofolate reductase (MTHFR) deficiency with extremely early onset: Characterization of two novel mutations in compound heterozygous patients.
Long term treatment with betaine in methylenetetrahydrofolate reductase deficiency.
Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice.
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-? in spleen and placenta, and through reduction of methylation potential.
Manifestations of neurological symptoms and thromboembolism in adults with MTHFR-deficiency.
Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice.
Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency.
Methotrexate-induced apoptosis is enhanced by altered expression of methylenetetrahydrofolate reductase.
Methylene Tetrahydrofolate Reductase Deficiency.
Methylene Tetrahydrofolate Reductase Deficiency: the Hidden Risk in Paediatric Anaesthesia.
Methylenetetrahydrofolate reductase (MTHFR) deficiency and infantile epilepsy.
Methylenetetrahydrofolate reductase (MTHFR) deficiency enhances resistance against cytomegalovirus infection.
Methylenetetrahydrofolate reductase (MTHFR) deficiency presenting as a rash.
Methylenetetrahydrofolate reductase deficiency (homocystinuria type II) as a rare cause of rapidly progressive tetraspasticity and psychosis in a previously healthy adult.
Methylenetetrahydrofolate reductase deficiency alters cellular response after ischemic stroke in male mice.
Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and ?-aminobutyric acid in brain tissue.
Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice.
Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice.
Methylenetetrahydrofolate Reductase Deficiency as a Cause of Treatable Adult-onset Leukoencephalopathy and Myelopathy.
Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-? Protein Precursor Expression and Phosphorylation Levels.
Methylenetetrahydrofolate reductase deficiency in a patient with phenotypic findings of Angelman syndrome.
Methylenetetrahydrofolate reductase deficiency in four siblings: a clinical, biochemical, and molecular study of the family.
Methylenetetrahydrofolate reductase deficiency revealed by a neuropathy in a psychotic adult.
Methylenetetrahydrofolate Reductase Deficiency: A Case Report.
Methylenetetrahydrofolate reductase deficiency: importance of early diagnosis.
Methylenetetrahydrofolate reductase deficiency: prenatal diagnosis and family studies.
Methylenetetrahydrofolate Reductase Deficiency: Rare but Considerable.
Methylenetetrahydrofolate reductase in cultured human cells. II. Genetic and biochemical studies of methylenetetrahydrofolate reductase deficiency.
Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.
Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates.
Microarray analysis of brain RNA in mice with methylenetetrahydrofolate reductase deficiency and hyperhomocysteinemia.
Mild Methylenetetrahydrofolate Reductase Deficiency Alters Inflammatory and Lipid Pathways in Liver.
Molecular biology of 5,10-methylenetetrahydrofolate reductase.
Molecular characterization of five patients with homocystinuria due to severe methylenetetrahydrofolate reductase deficiency.
Molecular genetics of methylenetetrahydrofolate reductase deficiency.
MR and proton MR spectroscopy of the brain in hyperhomocysteinemia caused by methylenetetrahydrofolate reductase deficiency.
Mthfr as a modifier of the retinal phenotype of Crb1(rd8/rd8) mice.
MTHFR C677T polymorphism is associated with hyperlipidemia in women with polycystic ovary syndrome.
Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1.
MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring.
MTHFR: Addressing Genetic Counseling Dilemmas Using Evidence-Based Literature.
Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms.
Mutation Update and Review of Severe Methylenetetrahydrofolate Reductase Deficiency.
Mutations of the MTHFR gene (428C>T and [458G>T+459C>T]) markedly decrease MTHFR enzyme activity.
Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines.
Newborn screening for homocystinurias: recent recommendations versus current practice.
Newborn screening for homocystinurias: Recent recommendations versus current practice.
Outcomes of four patients with homocysteine remethylation disorders detected by newborn screening.
Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations.
Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia.
Pearls & oy-sters: familial epileptic encephalopathy due to methylenetetrahydrofolate reductase deficiency.
Phenotype, treatment practice and outcome in the cobalamin-dependent remethylation disorders and MTHFR deficiency: data from the E-HOD registry.
Phenotype, treatment practice and outcome in the cobalamin-dependent remethylation disorders and MTHFR deficiency: Data from the E-HOD registry.
Posterior-predominant leukoencephalopathy which was caused by methylenetetrahydrofolate reductase deficiency and successfully treated with folic acid.
Postnatal cerebellar defects in mice deficient in methylenetetrahydrofolate reductase.
Pregnancy outcomes in women with epilepsy and MTHFR mutations supplemented with methylated folate and methylcobalamin (methylated B12).
Prenatal diagnosis for methylenetetrahydrofolate reductase deficiency.
Prenatal diagnosis for severe methylenetetrahydrofolate reductase deficiency by linkage analysis and enzymatic assay.
Prenatal Nutritional Intervention Reduces Autistic-Like Behavior Rates Among Mthfr-Deficient Mice.
Protein-bound homocyst(e)ine in normal subjects and in patients with homocystinuria.
Psychosis, paraplegia and coma revealing methylenetetrahydrofolate reductase deficiency in a 56-year-old woman.
Psychotic symptoms in severe MTHFR deficiency and their successful treatment with betaine.
Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency.
Rapidly progressive psychotic symptoms triggered by infection in a patient with methylenetetrahydrofolate reductase deficiency: a case report.
RE: Methylenetetrahydrofolate Reductase Deficiency: Rare but Considerable.
Relations between molecular and biological abnormalities in 11 families from siblings affected with methylenetetrahydrofolate reductase deficiency.
Remethylation defects: guidelines for clinical diagnosis and treatment.
Retinal ganglion cell loss and mild vasculopathy in methylene tetrahydrofolate reductase (Mthfr) deficient mice: a model of mild hyperhomocysteinemia.
Retinal vein occlusion associated with methylenetetrahydrofolate reductase mutation.
Reversible leukoencephalopathy and cerebral atrophy in Homocystinuria due to MTHFR deficiency: A treatable metabolic disorder.
Reversible leukoencephalopathy with acute neurological deterioration and permanent residua in classical homocystinuria: A case report.
Sequence Variation of the Methylene Tetrahydrofolate Reductase Gene (677C>T and 1298?A>C) and Traditional Risk Factors in a South Indian Population.
Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency.
Severe 5,10-methylenetetrahydrofolate reductase deficiency and two MTHFR variants in an adolescent with progressive myoclonic epilepsy.
Severe 5,10-methylenetetrahydrofolate reductase deficiency: a rare, treatable cause of complicated hereditary spastic paraplegia.
Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR.
Severe atherosclerosis in rheumatoid arthritis and hyperhomocysteinemia: is there a link?
Severe methylenetetrahydrofolate reductase (MTHFR) deficiency: a case report of nonclassical homocystinuria.
Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus.
Severe methylenetetrahydrofolate reductase deficiency revealed by a pulmonary embolism in a young adult.
Severe methylenetetrahydrofolate reductase deficiency, methionine synthase, and nitrous oxide--a cautionary tale.
Severe methylenetetrahydrofolate reductase deficiency: clinical clues to a potentially treatable cause of adult-onset hereditary spastic paraplegia.
Severe scoliosis in a patient with severe methylenetetrahydrofolate reductase deficiency.
Severe skin necrosis after breast reconstruction with a transverse rectus abdominis musculocutaneous flap in methylenetetrahydrofolate reductase deficiency.
Sex-dependent behavioral effects of Mthfr deficiency and neonatal GABA potentiation in mice.
Shifting landscapes of human MTHFR missense-variant effects.
Stability of DNA Methylation Patterns in Mouse Spermatogonia Under Conditions of MTHFR Deficiency and Methionine Supplementation.
Strain-Specific Defects in Testicular Development and Sperm Epigenetic Patterns in 5,10-Methylenetetrahydrofolate Reductase-Deficient Mice.
Supplementation with apple juice can compensate for folate deficiency in a mouse model deficient in methylene tetra hydrofoate reductase activity.
Survival and psychomotor development with early betaine treatment in patients with severe methylenetetrahydrofolate reductase deficiency.
Symptomatic and asymptomatic methylenetetrahydrofolate reductase deficiency in two adult brothers.
Targeted cerebrospinal fluid analysis for inborn errors of metabolism on an LC-MS/MS analysis platform.
Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation.
Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation.
The 1316T>C missenses mutation in MTHFR contributes to MTHFR deficiency by targeting MTHFR to proteasome degradation.
The clinical presentation of cobalamin-related disorders: From acquired deficiencies to inborn errors of absorption and intracellular pathways.
The Effect of in Vitro Homocystinuria on the Suckling Rat Hippocampal Acetylcholinesterase.
The effect of in vitro homocystinuria on the suckling rat hippocampal acetylcholinesterase.
The thermolabile variant 677C-->T can further reduce activity when expressed in cis with severe mutations for human methylenetetrahydrofolate reductase.
Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.
Treatment of inherited homocystinurias.
Treatment with Mefolinate (5-Methyltetrahydrofolate), but Not Folic Acid or Folinic Acid, Leads to Measurable 5-Methyltetrahydrofolate in Cerebrospinal Fluid in Methylenetetrahydrofolate Reductase Deficiency.
Two-Tier Approach to the Newborn Screening of Methylenetetrahydrofolate Reductase Deficiency and Other Remethylation Disorders with Tandem Mass Spectrometry.
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency.
[Case of juvenile stroke caused by methylenetetrahydrofolate reductase deficiency]
[Cystathionine betasynthase and MTHFR deficiencies in adults]
[Diet therapy and coenzyme therapy in hereditary metabolic diseases]
[Effect of folic acid for treatment of homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency]
[Hyperhomocysteinemia--a risk factor for development of occlusive vascular diseases]
[Methylenetetrahydrofolate reductase deficiency-induced schizophrenia in a school-age boy].
[Methylenetetrahydrofolate reductase deficiency]
[Molecular genetics of MTHFR: polymorphisms are not all benign]
Micrognathism
A Bibliometric Analysis of Cleft Lip and Palate-Related Publication Trends From 2000 to 2017.
Microvascular Angina
Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation.
Migraine Disorders
Aberrant DNA methylation pattern may enhance susceptibility to migraine: A novel perspective.
Analysis of the MTHFR C677T variant with migraine phenotypes.
Are the methylenetetrahydrofolate reductase 1298 and 677 gene polymorphisms related to optic glioma and hamartoma risk in neurofibromatosis type 1 patients?
Association of MTHFR C677T polymorphism with susceptibility to migraine in the Chinese population.
Association of MTHFR gene polymorphisms with migraine in North Indian population.
Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk.
Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis.
Association of von Willebrand factor activity with ACE I/D and MTHFR C677T polymorphisms in migraine.
Comment on Rubino et al., 'Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis'.
Do Folate, Vitamins B6 and B12 Play a Role in the Pathogenesis of Migraine? The Role of Pharmacoepigenomics.
Effects of dietary folate intake on migraine disability and frequency.
Effects of MTHFR C677T and A1298C Polymorphisms on Migraine Susceptibility: A Meta-Analysis of 26 Studies.
Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine.
Efficacy of Folic Acid in Children With Migraine, Hyperhomocysteinemia and MTHFR Polymorphisms.
Emerging Role of Polymorphisms of the MTHFR Gene in Systemic Carcinogenesis Besides Their Role in Migraines.
Frequency of the C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene in patients with migraine with or without aura - a preliminary report.
Genetic biomarkers for migraine.
Genetic epidemiology of migraine and depression.
Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility.
Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation.
Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura.
Hypercoagulability and Migraine.
Influence of MTHFR genotype on contingent negative variation and MRI abnormalities in migraine.
Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine.
Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease.
Investigation of MTHFR C677T Gene Polymorphism, Biochemical and Clinical Parameters in Turkish Migraine Patients: Association with Allodynia and Fatigue.
Is an "Epigenetic Diet" for Migraines Justified? The Case of Folate and DNA Methylation.
Joint Metabonomic and Instrumental Analysis for the Classification of Migraine Patients with 677-MTHFR Mutations.
Lack of association between the MTHFR C677T variant and migraine with aura in an older population: Could selective survival play a role?
MAOA, MTHFR, and TNF-? genes polymorphisms and personality traits in the pathogenesis of migraine.
Metabolic and genetic risk factors for migraine in children.
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and migraine.
Methylenetetrahydrofolate reductase gene variant (MTHFR C677T) and migraine: a case control study and meta-analysis.
Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service.
Migraine and coronary artery disease: an open study on the genetic polymorphism of the 5, 10 methylenetetrahydrofolate (MTHFR) and angiotensin I-converting enzyme (ACE) genes.
Migraine and genetic polymorphisms: an overview.
Migraine and MTHFR C677T genotype in a population-based sample.
Migraine mediates the influence of C677T MTHFR genotypes on ischemic stroke risk with a stroke-subtype effect.
Migraine: Genetic Variants and Clinical Phenotypes.
Molecular factors in migraine.
MTHFR 677C-->T and ACE D/I polymorphisms and migraine attack frequency in women.
MTHFR 677C>T and ACE D/I Polymorphisms in Migraine: A Systematic Review and Meta-Analysis.
MTHFR and ACE Polymorphisms Do Not Increase Susceptibility to Migraine Neither Alone Nor in Combination.
MTHFR C677T polymorphism and migraine risk: a meta-analysis.
MTHFR C677T polymorphism and migraine with aura.
MTHFR T677 homozygosis influences the presence of aura in migraineurs.
Plasma homocysteine in patients of migraine without aura.
Predictive index for the onset of medication overuse headache in migraine patients.
Role of Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C>T Polymorphism in Pediatric Cerebrovascular Disorders.
Role of the ACE ID and MTHFR C677T polymorphisms in genetic susceptibility of migraine in a north Indian population.
Search for correlations between genotypes and electrophysiological patterns in migraine: the MTHFR C677T polymorphism and visual evoked potentials.
Targeting MTHFR for the treatment of migraines.
Testing of variants of the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association with migraine with aura.
The C677T polymorphism in MTHFR is not associated with migraine in Portugal.
The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability.
The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine.
The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura.
The Relationship Between Homocysteine and Genes of Folate-Related Enzymes in Migraine Patients.
The Role of the MTHFR Gene in Migraine.
The rs4846049 polymorphism in the 3'UTR region of the
Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele.
Update on the genetics of migraine.
[An update on the familial headache syndromes]
[Cortical spreading depression and molecular genetics in migraine].
[Genetic analysis of migraine headache: a review]
[Metabolic syndrome and prevention of migraine headache]
[Mutation of MTHFR gene as marker of endothelial dysfunction in patients diagnosed of migraine with aura.]
Migraine with Aura
Analysis of the MTHFR C677T variant with migraine phenotypes.
Association of MTHFR gene polymorphisms with migraine in North Indian population.
Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk.
Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis.
Effects of dietary folate intake on migraine disability and frequency.
Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine.
Genetic biomarkers for migraine.
Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura.
Influence of MTHFR genotype on contingent negative variation and MRI abnormalities in migraine.
Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease.
Lack of association between the MTHFR C677T variant and migraine with aura in an older population: Could selective survival play a role?
Migraine mediates the influence of C677T MTHFR genotypes on ischemic stroke risk with a stroke-subtype effect.
MTHFR 677C>T and ACE D/I Polymorphisms in Migraine: A Systematic Review and Meta-Analysis.
MTHFR C677T polymorphism and migraine with aura.
Targeting MTHFR for the treatment of migraines.
Testing of variants of the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association with migraine with aura.
The C677T polymorphism in MTHFR is not associated with migraine in Portugal.
The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura.
The Role of the MTHFR Gene in Migraine.
Update on the genetics of migraine.
[Mutation of MTHFR gene as marker of endothelial dysfunction in patients diagnosed of migraine with aura.]
Migraine without Aura
Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk.
Migraine mediates the influence of C677T MTHFR genotypes on ischemic stroke risk with a stroke-subtype effect.
Mitochondrial Diseases
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Mouth Neoplasms
Are factor V and prothrombin mutations associated with increased risk of oral cancer?
Association of MTHFR C677T and A1298C polymorphisms with oral cancer susceptibility: evidence from a meta-analysis.
Folate intake, serum homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T genotype are not associated with oral cancer risk in Puerto Rico.
Folate supplementation induces differential dose-dependent modulation of proliferative phenotypes among cancerous and noncancerous oral cell lines in vitro.
Influence of methylenetetrahydrofolate reductase polymorphisms in oral cancer patients.
Interaction between the MTHFR C677T Polymorphism and Alcohol: Impact on Oral Cancer Risk and Multiple DNA Methylation of Tumor-related Genes.
Methylenetetrahydrofolate reductase (MTHFR) genotype, smoking habit, metastasis and oral cancer in Taiwan.
Methylenetetrahydrofolate reductase polymorphism and minor increase of risk for oral cancer.
Polymorphisms in methylenetetrahydrofolate reductase and cystathionine beta-synthase in oral cancer - a case-control study in southeastern Brazilians.
Positive association between MTHFR C677T polymorphism and oral cancer risk: a meta-analysis.
Tyms double (2R) and triple repeat (3R) confers risk for human oral squamous cell carcinoma.
Moyamoya Disease
The roles of methylenetetrahydrofolate reductase 677C>T and 1298A>C polymorphisms in moyamoya disease patients.
Mucocutaneous Lymph Node Syndrome
METHYLENETETRAHYDROFOLATE REDUCTASE C677T POLYMORPHISM IN PATIENTS WITH HENOCH-SCHÖNLEIN PURPURA.
Methylenetetrahydrofolate reductase polymorphism in Kawasaki disease.
Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population.
Mucositis
Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma.
Association of MTHFR and ABCB1 polymorphisms with MTX-induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma-A retrospective cohort study.
Associations between the C677T and A1298C polymorphisms of MTHFR and the toxicity of methotrexate in childhood malignancies: a meta-analysis.
DPYD*2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer.
Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis.
Identifying novel genes and biological processes relevant to the development of cancer therapy-induced mucositis: An informative gene network analysis.
Impact of thrombophilic gene mutations and graft-versus-host disease on thromboembolic complications after allogeneic hematopoietic stem-cell transplantation.
Influence of plasma methotrexate level and MTHFR genotype in Korean paediatric patients with acute lymphoblastic leukaemia.
Methotrexate-induced mucositis in acute leukemia patients is not associated with the MTHFR 677T allele in Mexico.
Mexican Childhood Acute Lymphoblastic Leukemia: A Pilot Study of the MDR1 and MTHFR Gene Polymorphisms and Their Associations with Clinical Outcomes.
MTHFR gene polymorphisms and methotrexate toxicity in adult patients with hematological malignancies: a meta-analysis.
Pharmacogenetic Variants in MTHFR Gene are Significant Predictors of Methotrexate Toxicities in Bangladeshi Patients With Acute Lymphoblastic Leukemia.
Role of folate status and methylenetetrahydrofolate reductase genotype on the toxicity and outcome of induction chemotherapy in children with acute lymphoblastic leukemia.
Multiple Chemical Sensitivity
Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR.
Multiple Myeloma
Analysis of MTHFR polymorphisms and P16 methylation and their correlation with clinical-biological features of multiple myeloma.
Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies.
Meta-analysis of the association of MTHFR polymorphisms with multiple myeloma risk.
Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin's lymphoma or multiple myeloma.
Methylenetetrahydrofolate reductase 677CC normal genotype may protect against multiple myeloma.
Methylenetetrahydrofolate reductase genotype does not play a role in multiple myeloma pathogenesis.
Normal frequencies of the C677T genotypes on the methylenetetrahydrofolate reductase (MTHFR) gene among lymphoproliferative disorders but not in multiple myeloma.
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk.
Should we screen patients for inherited thrombophilia before starting thalidomide?
Study of specific genetic and epigenetic variables in multiple myeloma.
The role of MTHFR gene in multiple myeloma.
[A new method for 5, 10-methylenetetrahydrofolate reductase single nucleotide polymorphisms genotyping used to study susceptibility of hematological malignancy]
[PROVISIONAL] The differential effects of the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) on hematological malignancies among Latinos: a meta-analysis.
Multiple Sclerosis
A methylenetetrahydrofolate reductase gene polymorphism in multiple sclerosis.
Association Between MTHFR Genetic Variants and Multiple Sclerosis in a Southern Iranian Population.
Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients.
Association of methylenetetrahydrofolate reductase gene C677T polymorphism with multiple sclerosis in Turkish patients.
Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis.
Genetic variants of homocysteine metabolism and multiple sclerosis: a case-control study.
Inflammatory Profile, Age of Onset, and the MTHFR Polymorphism in Patients with Multiple Sclerosis.
Meta-analysis of associations between MTHFR and GST polymorphisms and susceptibility to multiple sclerosis.
Relationship between genetic polymorphisms MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) genes and multiple sclerosis: a case-control study.
The variant methylenetetrahydrofolate reductase c.1298A>C (p.E429A) is associated with multiple sclerosis in a German case-control study.
Multiple Sclerosis, Relapsing-Remitting
Genetic variants of homocysteine metabolism and multiple sclerosis: a case-control study.
Muscle Cramp
Sacroiliitis and muscle cramps in a healthy young man: some spearhead on MTHFR mutations.
Muscle Hypotonia
Severe scoliosis in a patient with severe methylenetetrahydrofolate reductase deficiency.
Muscle Weakness
Mutations in MTHFR and POLG impaired activity of the mitochondrial respiratory chain in 46-year-old twins with spastic paraparesis.
Muscular Diseases
Betaine for treatment of homocystinuria caused by methylenetetrahydrofolate reductase deficiency.
[Genotype and phenotype analysis of neonates with neonatal encephalopathy complicated with perinatal hypoxic event].
Musculoskeletal Pain
Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.
Myelitis
Longitudinal myelitis in patient with systemic lupus erythematosus, homozygous prothrombin G20210A and heterozygous MTHFR 677T.
Myelodysplastic Syndromes
MTHFR polymorphysms in myelodysplastic syndromes and therapy-related myeloid neoplasms.
MTHFR, TS and XRCC1 genetic variants may affect survival in patients with myelodysplastic syndromes treated with supportive care or azacitidine.
The genetics of pyoderma gangrenosum and implications for treatment: a systematic review.
Myocardial Infarction
A case report of myocardial infarction in young patient with a parental history of premature cardiovascular death: combination of prothrombotic gene mutations.
A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction.
A mutation in the methylenetetrahydrofolate reductase gene is not associated with increased risk for coronary artery disease or myocardial infarction.
Acute renal infarction associated with homozygous methylenetetrahydrofolate reductase mutation C677T and IgA beta-2-glycoprotein antibodies.
An association analysis between genetic polymorphisms of matrix metalloproteinase-3 and methylenetetrahydrofolate reductase and myocardial infarction in Japanese.
Assessment of genetic risk for myocardial infarction.
Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies.
Association Between Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Risk of Myocardial Infarction: Need for Clarification of Data in a Recent Meta-analysis.
Association Between Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) C677T and Risk of Myocardial Infarction: A Meta-analysis for 8,140 Cases and 10,522 Controls.
Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction.
Association of Genetic Variants of MTHFR, ENPP1, and ADIPOQ with Myocardial Infarction in Egyptian Patients.
Association of methylenetetrahydrofolate reductase gene polymorphism with carotid arterial wall thickening and myocardial infarction risk in NIDDM.
C667T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene and susceptibility to myocardial infarction: A systematic review and meta-analysis.
C677T polymorphism of the 5,10 MTHFR gene in young Mexican subjects with ST-elevation myocardial infarction.
Case report: Acute myocardial infarction in a 32-year-old white male found to have antiphospholipid antibody syndrome and MTHFR mutation homozygosity.
Coexistence of prothrombic risk factors and its relation to left ventricular thrombus in acute myocardial infarction.
Combination of factor V Leiden and MTHFR mutations in myocardial infarction.
Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica.
Compound heterozygous MTHFR (C677T and A1298C) variants and anterior STEMI: cause or bystander?
D allele of the angiotensin-converting enzyme gene is a risk factor for secondary cardiac events after myocardial infarction.
Factor V G1691A, apo E4 allele, hyperhomocysteinemia and MTHFR C677T in a young patient with myocardial infarction.
Folate, homocysteine levels, methylenetetrahydrofolate reductase (MTHFR) 677C --> T variant, and the risk of myocardial infarction in young women: effect of female hormones on homocysteine levels.
Gene polymorphisms of homocysteine metabolism-related enzymes in Chinese patients with occlusive coronary artery or cerebral vascular diseases.
Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction.
Genetic polymorphism of 5,10-methylenetetrahydrofolate increases risk of myocardial infarction and is correlated to elevated levels of homocysteine in the Japanese general population.
Genetic polymorphism of 5,10-MTHFR reductase gene in offspring of patients with myocardial infarction.
Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. A case-control study.
Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.
Genetic polymorphisms in preoperative myocardial infarction.
Genetic polymorphisms, Biochemical Factors, and Conventional Risk Factors in Young and Elderly North Indian Patients With Acute Myocardial Infarction.
Genetic risk factors in acute coronary disease.
Homocyst(e)ine and the C677T mutation of methylenetetrahydrofolate reductase in survivors of premature myocardial infarction.
Homocysteine levels and MTHFR polymorphisms in young patients with acute myocardial infarction: a case control study.
Homozygosity for the C677-->T mutation of 5,10-methylenetetrahydrofolate reductase and total plasma homocyst(e) ine are not associated with greater than normal risk of a first myocardial infarction in northern Sweden.
Homozygosity of the TT methylenetetrahydrofolate reductase C677T genotype is an independent long-term predictor of cardiac death in patients with premature myocardial infarction.
Lack of association of methylenetetrahydrofolate reductase 677C>T mutation with coronary artery disease in a Pakistani population.
Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?
Methylenetetrahydrofolate reductase gene and coronary artery disease.
Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myocardial infarction.
Methylenetetrahydrofolate Reductase Polymorphism and Premature Coronary Artery Disease.
Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians.
Methylentetrahydrofolate Reductase and Nitric Oxide Synthase Polymorphism in Patients with Atherosclerosis and Diabetes.
Migraine and coronary artery disease: an open study on the genetic polymorphism of the 5, 10 methylenetetrahydrofolate (MTHFR) and angiotensin I-converting enzyme (ACE) genes.
MTHFR (Ala 222 Val) polymorphism and AMI in patients with type II diabetes mellitus.
MTHFR C677T polymorphism among Meiteis of Manipur (India).
MTHFR C677T Polymorphism and Its Relationship to Myocardial Infarction in the Eastern Black Sea Region of Turkey.
MTHFR Gene polymorphisms, B-vitamins and hyperhomocystinemia in young and middle-aged acute myocardial infarction patients.
MTHFR polymorphism and risk of periprocedural myocardial infarction after coronary stenting.
Mutations in the genes regulating methylene tetrahydrofolate reductase (MTHFR C-->T677) and cystathione beta-synthase (CBS G-->A919, CBS T-->c833) are not associated with myocardial infarction in African Americans.
Myocardial infarction and venous thrombosis in a 42-year old woman with heterozygous methylenetetrahydrofolate reductase (MTHRF) gene mutation, hyperhomocysteinemia, and protein C deficiency.
Myocardial Infarction in a Newborn Heterozygous for the MTHFR C677T Mutation.
Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene.
No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age.
Polymorphisms in MTHFR, MS and CBS genes and premature acute myocardial infarction in a Pakistani population.
Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects.
Prothrombotic gene polymorphisms and plasma factors in young north Indian survivors of acute myocardial infarction.
Prothrombotic genetic risk factors in young survivors of myocardial infarction.
Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C).
Reply: Association Between Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Risk of Myocardial Infarction: Need for Clarification of Data in a Recent Meta-analysis.
Risk factors and methylenetetrahydrofolate reductase gene polymorphisms in a young South African Indian-based population with acute myocardial infarction.
Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of premature myocardial infarction.
Sequence Variation of the Methylene Tetrahydrofolate Reductase Gene (677C>T and 1298?A>C) and Traditional Risk Factors in a South Indian Population.
ST-elevation myocardial infarction, pulmonary embolism, and cerebral ischemic stroke in a patient with critically low levels of natural anticoagulants.
Successful conservative treatment of myocardial infarction in a teenager with MTHFR mutation.
Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males.
The C677T mutation of the methylenetetrahydrofolate reductase gene is not associated with the risk of coronary artery disease or venous thrombosis among Chinese in Taiwan.
The genotype interactions of methylenetetrahydrofolate reductase and renin-angiotensin system genes are associated with myocardial infarction.
The methylenetetrahydrofolate reductase (MTHFR) 677C-->T mutation and cardiovascular risk--A case of ischemic stroke and acute myocardial infarction.
The role and importance of gene polymorphisms in the development of atherosclerosis.
The rs1801133 polymorphism of methylenetetrahydrofolate reductase gene- the association with 5-year survival in patients with ST-elevation myocardial infarction.
The TT genotype of the methylenetetrahydrofolate reductase C677T gene polymorphism is associated with the extent of coronary atherosclerosis in patients at high risk for coronary artery disease.
[Allelic variants of genes: angiotensin I-converting enzyme (ACE), angiotensin-II type 1 receptor (AT1R), methylenetetrahydrofolate reductase and left ventricular mass in patients with myocardial infarction]
[Association of methylenetetrahydrofolate reductase gene polymorphism with the development of myocardial infarction in patients with type 2 diabetes].
[C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in patients with myocardial infarction]
[Gene Polymorphism of 5, 10-methylenetetrahydrofolate reductase as a coronary risk factor]
[Increase of homocysteine in cardiovascular diseases in Hungary]
[Polymorphism of genes coding for angiotensin I converting enzyme and methylenetetrahydrofolate reductase in patients with ischemic heart disease]
[Study on homocysteine metabolism related enzymes gene mutations in Chinese patients with ischemic cardiovascular and cerebrovascular diseases]
Myocardial Ischemia
Epistasis analysis of metabolic genes polymorphisms associated with ischemic heart disease in Yucatan.
Family history, plasma homocysteine, and age at onset of symptoms of myocardial ischemia in patients with different methylenetetrahydrofolate reductase genotypes.
Plasma homocysteine, methylenetetrahydrofolate reductase genotypes, and age at onset of symptoms of myocardial ischemia.
Polymorphisms C677T and A1298C of MTHFR Gene: Homocysteine Levels and Prothrombotic Biomarkers in Coronary and Pulmonary Thromboembolic Disease.
[Distributions of polymorphisms of genes of some components of hemostasis in patients with ischemic heart disease]
[Polymorphism of genes coding for angiotensin I converting enzyme and methylenetetrahydrofolate reductase in patients with ischemic heart disease]
Myoclonic Epilepsies, Progressive
Severe 5,10-methylenetetrahydrofolate reductase deficiency and two MTHFR variants in an adolescent with progressive myoclonic epilepsy.
nadh:ubiquinone reductase (h+-translocating) deficiency
Recessive spastic paraparesis associated with complex I deficiency due to MTHFR mutations.
Nasopharyngeal Carcinoma
Polymorphisms of methylenetetrahydrofolate reductase are associated with a high risk of nasopharyngeal carcinoma in a smoking population from Southern China.
Neoplasm Metastasis
Genetic polymorphisms and response to 5-fluorouracil, doxorubicin and cyclophosphamide chemotherapy in breast cancer patients.
Genetic variants in 3'-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans.
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
Methylenetetrahydrofolate reductase (MTHFR) genotype, smoking habit, metastasis and oral cancer in Taiwan.
Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients.
Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients.
The 677C > T mutation in 5,10-methylenetetrahydrofolate reductase and colorectal cancer risk.
Which gene is a dominant predictor of response during FOLFOX chemotherapy for the treatment of metastatic colorectal cancer, the MTHFR or XRCC1 gene?
[Association between genetic variations in methylenetetrahydrofolate reductase and risk of colorectal cancer in a Chinese population]
Neoplasm, Residual
Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia.
Neoplasms
5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer.
5,10-Methylenetetrahydrofolate reductase polymorphisms and pharmacogenetics: a new role of single nucleotide polymorphisms in the folate metabolic pathway in human health and disease.
667C>T and 1298A>C polymorphisms of MTHFR do not predict response to methotrexate in patients with gestational trophoblastic neoplasia.
A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer.
A Daily Dose of 5 mg Folic Acid for 90 Days Is Associated with Increased Serum Unmetabolized Folic Acid and Reduced Natural Killer Cell Cytotoxicity in Healthy Brazilian Adults.
A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation.
A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk.
A lower degree of PBMC L1 methylation in women with lower folate status may explain the MTHFR C677T polymorphism associated higher risk of CIN in the US post folic acid fortification era.
A methylenetetrahydrofolate reductase polymorphism is associated with expression of p16 in human lung cancer.
A novel single nucleotide polymorphism of the human methylenetetrahydrofolate reductase gene in Japanese individuals.
A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability.
A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma.
A retrospective comparative exploratory study on two Methylentetrahydrofolate Reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patients.
A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage.
Aberrant DNA Methylation associated with MTHFR C677T Genetic Polymorphism in cutaneous squamous cell carcinoma in renal transplant patients.
Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism in gastric cancer.
Aberrant DNA Methylation of P16, MGMT, hMLH1 and hMSH2 Genes in Combination with the MTHFR C677T Genetic Polymorphism in Gastric Cancer.
Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer.
ACE I/D sequence variants but not MTHFR C677T, is strongly linked to malignant glioma risk and its variant DD genotype may act as a promising predictive biomarker for overall survival of glioma patients.
Advances in cancer epidemiology in Japan.
Allelic variations in 5, 10-methylenetetrahydrofolate reductase gene and susceptibility to cervical cancer in Indian women.
Analysis of the methylation patterns of the p16 (INK4A) , p15 (INK4B) , and APC genes in gastric adenocarcinoma patients from a Brazilian population.
Analysis of the MTHFR (methylenetetrahydrofolate reductase) 677 C>T and 1298 A>C polymorphisms in BCR-ABL-negative myeloproliferative neoplasms.
Antisense inhibition of methylenetetrahydrofolate reductase reduces cancer cell survival in vitro and tumor growth in vivo.
Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour lines.
Are the methylenetetrahydrofolate reductase 1298 and 677 gene polymorphisms related to optic glioma and hamartoma risk in neurofibromatosis type 1 patients?
Association between 11 genetic polymorphisms in folate-metabolising genes and head and neck cancer risk.
Association between methylenetetrahydrofolate reductase gene rs1801131 A/C polymorphism and urinary tumors' susceptibility.
Association between methylenetetrahydrofolate reductase polymorphisms, alcohol intake and oropharyngolaryngeal carcinoma in northern Italy.
Association between MTHFR C677T, MTHFR A1298C and MS A2756G polymorphisms and risk of cervical intraepithelial neoplasia II/III and cervical cancer: A meta-analysis.
Association between MTHFR Gene Polymorphism and the Risk of Ovarian Cancer: A Meta-analysis of the Literature.
Association between MTHFR Gene Polymorphisms and the Risk of Autism Spectrum Disorders: A Meta-Analysis.
Association between polymorphisms of folate-metabolizing enzymes and risk of prostate cancer.
Association between the 1793G> A MTHFR polymorphism and sporadic colorectal cancer in Iran.
Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in serbian children.
Association between the MTHFR A1298C polymorphism and risk of cancer: evidence from 265 case-control studies.
Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies.
Association of Folate and Vitamins Involved in the 1-Carbon Cycle with Polymorphisms in the Methylenetetrahydrofolate Reductase Gene (MTHFR) and Global DNA Methylation in Patients with Colorectal Cancer.
Association of Intake Folate and Related Gene Polymorphisms with Breast Cancer.
Association of Methylenetetrahydrafolate Reductase Gene Polymorphism (MTHFR) in Patients with Gallbladder Cancer.
Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population.
Association of methylenetetrahydrofolate reductase gene polymorphisms & colorectal cancer in India.
Association of methylenetetrahydrofolate reductase gene polymorphisms and sex-specific survival in patients with metastatic colon cancer.
Association of MTHFR 677C>T, 1298A>C and MTR 2756A>G Polymorphisms with Risk of Retinoblastoma.
Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis.
Association of Polymorphisms in Genes Involved in One-Carbon Metabolism with MTHFR Methylation Levels.
Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy.
Association of the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) polymorphisms in Korean patients with adult acute lymphoblastic leukemia.
Association of the 677C -->T polymorphism in the MTHFR gene with colorectal cancer in Mexican patients.
Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population.
Association of the functional polymorphism C677T in the methylenetetrahydrofolate reductase gene with colorectal, thyroid, breast, ovarian, and cervical cancers.
Association of the MTHFR C677T polymorphism with primary brain tumor risk.
Association of the MTHFR Gene C677T Polymorphism with Breast Cancer in a Turkish Population.
Association of the polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma.
Associations between family history of cancer and genes coding for metabolizing enzymes (United States).
Associations between methylenetetrahydrofolate reductase polymorphisms and hepatocellular carcinoma risk in Chinese population.
Associations between the C677T and A1298C polymorphisms of MTHFR and the toxicity of methotrexate in childhood malignancies: a meta-analysis.
Associations of plasma homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism with carotid intima media thickness among South Asian, Chinese and European Canadians.
Biological and clinical implications of the MTHFR C677T polymorphism.
Breast cancer risk, dietary intake, and methylenetetrahydrofolate reductase (MTHFR)single nucleotide polymorphisms.
C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and high-grade gliomas.
Candidate genetic markers and the risk of restenosis after coronary angioplasty.
CDA and MTHFR polymorphisms are associated with clinical outcomes in gastroenteric cancer patients treated with capecitabine-based chemotherapy.
Chapter 13 methylenetetrahydrofolate reductase, common polymorphisms, and relation to disease.
Characterization of a pseudogene for murine methylenetetrahydrofolate reductase.
Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels.
Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12.
Comparison of Capillary Electrophoresis, AGE, and PAGE for MTHFR Polymorphism Analysis in FFPE Cervical Samples.
Comparison of standard PCR and the LightCycler technique to determine the thrombophilic mutations: an efficiency and cost study.
Comprehensive analysis of Methylenetetrahydrofolate reductase C677T in younger acute lymphoblastic leukemia patients: A single-center experience.
Comprehensive evaluation of one-carbon metabolism pathway gene variants and renal cell cancer risk.
Determinants of homocysteine levels in colorectal and breast cancer patients.
Diet and prevention of colorectal cancer.
Dietary folate intake in combination with MTHFR C677T genotype and promoter methylation of tumor suppressor and DNA repair genes in sporadic colorectal adenomas.
Dietary vitamin B6 intake and the risk of colorectal cancer.
Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: a meta-analysis.
Dihydropyrimidine Dehydrogenase 85T>C Mutation Is Associated With Ocular Toxicity of 5-Fluorouracil: A Case Report.
DNA methylation and sensitivity to antimetabolites in cancer cell lines.
DNA methylation changes associated with cancer risk factors and blood levels of vitamin metabolites in a prospective study.
DNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract.
DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status.
Easy detection of 5,10-methylenetetrahydrofolate reductase 1298A/C genotype by mutagenically separated PCR assay.
Effect of cystathionine beta-synthase variant 844ins68bp and methylenetetrahydrofolate reductase A1298C polymorphisms in xenografts on 5-FU efficacy and doubling time.
Effect of folic acid supplementation on cancer risk among adults with hypertension in China: A randomized clinical trial.
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.
Effect of the methylenetetrahydrofolate reductase gene C677T polymorphism on C-erbB-2 methylation status and its association with cancer.
Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities.
Effects of the MTHFR C677T Polymorphism on Prostate Specific Antigen and Prostate Cancer.
Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer.
Epidemiologic studies of folate and colorectal neoplasia: a review.
Epigenetics in Clinical Practice: Characterizing Patient and Provider Experiences with MTHFR Polymorphisms and Methylfolate.
Epithelial-Mesenchymal Transition and MicroRNAs in Colorectal Cancer Chemoresistance to FOLFOX.
Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, China.
Evaluation of the contribution of methylenetetrahydrofolate reductase genotypes to Taiwan breast cancer.
Evaluation of the MTHFR C677T Polymorphism as a Risk Factor for Colorectal Cancer in Asian Populations.
Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer.
Fission Yeast Methylenetetrahydrofolate Reductase Ensures Mitotic and Meiotic Chromosome Segregation Fidelity.
Folate enzymes in Ehrlich ascites carcinoma-bearing mice.
Folate intake and methylenetetrahydrofolate reductase gene polymorphisms as predictive and prognostic biomarkers for ovarian cancer risk.
Folate intake, methylenetetrahydrofolate reductase polymorphisms, and breast cancer risk in women from the Malmö Diet and Cancer cohort.
Folate pathway genetic polymorphisms and susceptibility of central nervous system tumors in Thai children.
Folate restriction and methylenetetrahydrofolate reductase 677T polymorphism decreases adoMet synthesis via folate-dependent remethylation in human-transformed lymphoblasts.
Folate status among patients with non-small cell lung cancer: a case-control study.
Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study.
Folate status: effects on pathways of colorectal carcinogenesis.
Folate, DNA methylation and colo-rectal cancer.
Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia.
Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations.
Folate-related genes and the risk of tobacco-related cancers in Central Europe.
Folic acid: miscarriages, anomalies, thromboses, cancers.
Food Intervention with Folate Reduces TNF-? and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial.
Frequencies of poor metabolizer alleles of 12 pharmacogenomic actionable genes in Punjabi Sikhs of Indian Origin.
FV Leiden mutation and risk of recurrent venous thromboembolism in Serbian population.
Gender-specific association of methylenetetrahydrofolate reductase genotype and haplotype with the aggressiveness and prognosis of clear cell renal cell carcinoma in Japanese patients.
Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma.
Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer.
Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis.
Genetic and epigenetic variants in the MTHFR gene are not associated with non-Hodgkin lymphoma.
Genetic and epigenetic variation in the DNMT3B and MTHFR genes and colorectal adenoma risk.
Genetic polymorphisms and multiple myeloma risk: a meta-analysis.
Genetic polymorphisms in folate- metabolizing enzymes and risk of gastroesophageal cancers: a potential nutrient-gene interaction in cancer development.
Genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase and risk of pancreatic cancer.
Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic.
Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East.
Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan.
Genetic variants in 3'-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans.
Genetic variation in the folate metabolic pathway and risk of childhood leukemia.
Genetic variations in MTHFR and gastric cardia adenocarcinoma susceptibility in the Chinese Han population.
Genome-wide Hypomethylation in Human Glioblastomas Associated with Specific Copy Number Alteration, Methylenetetrahydrofolate Reductase Allele Status, and Increased Proliferation.
Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene.
Genotype phenotype correlations in Israeli colorectal cancer patients.
Geographical and ethnic distribution of MTHFR gene polymorphisms and their associations with diseases among Chinese population.
Germ-line MTHFR C677T, FV H1299R and PAI-1 5G/4G Variations in Breast Carcinoma.
Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study.
Head and neck cancer: genetic polymorphisms and folate metabolism.
Heterozygote advantage of methylenetetrahydrofolate reductase polymorphisms on clinical outcomes in advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy.
High resolution array comparative genomic hybridization identifies copy number alterations in diffuse large B-cell lymphoma that predict response to immuno-chemotherapy.
High-resolution melting curve analysis for genotyping of common SNP in MTHFR gene using fixed-cell suspension.
How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy.
Hyperhomocysteinemia and MTHFR C677T polymorphism in patients with portal vein thrombosis complicating liver cirrhosis.
Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism, and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls.
Hypomethylation and hypermethylation of DNA in Wilms tumors.
Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer.
Identification of microRNAs associated with abdominal aortic aneurysms and peripheral arterial disease.
Immunohistochemical and genetic prognostic factors of neoadjuvant chemoradiotherapy effic?cy in personalized treatment of local advanced rectal cancer.
Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site.
Impact of thrombophilic genes mutations on thrombosis risk in Egyptian nonmetastatic cancer patients.
Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas.
Improved real-time multiplex polymerase chain reaction detection of methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C polymorphisms using nearest neighbor model-based probe design.
In human alleles specific variation of MTHFR C677T and A1298C associated "risk factor" for the development of ovarian cancer.
Increased breast cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele.
Influence of cancer-related gene polymorphisms on clinicopathological features in colorectal cancer.
Influence of MTHFR Genetic Background on p16 and MGMT Methylation in Oral Squamous Cell Cancer.
Interaction among folate, riboflavin, genotype, and cancer, with reference to colorectal and cervical cancer.
Interaction between alcohol consumption and methylenetetrahydrofolate reductase polymorphisms in thyroid cancer risk: National Cancer Center cohort in Korea.
Interaction of methylenetetrahydrofolate reductase genotype and smoking habit in Taiwanese lung cancer patients.
Interactions Between MTHFR C677T - A1298C Variants and Folic Acid Deficiency Affect Breast Cancer Risk in a Chinese Population.
Intraindividual somatic variations in MTHFR gene polymorphisms in relation to colon cancer.
Involvement of gene polymorphisms of the folate pathway enzymes in gene expression and anticancer drug sensitivity using the NCI-60 panel as a model.
Is genetic screening necessary for determining the possibility of venous thromboembolism in cancer patients?
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
Lack of association between methylenetetrahydrofolate reductase C677T polymorphism, HPV infection and cervical intraepithelial neoplasia in Brazilian women.
Lack of association between the C677T MTHFR polymorphism and colorectal hyperplastic polyps.
Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease.
Loss of heterozygosity at the 5,10-methylenetetrahydrofolate reductase locus in human ovarian carcinomas.
Loss of heterozygosity of methylenetetrahydrofolate reductase in colon carcinomas.
Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.
MAOA, MTHFR, and TNF-? genes polymorphisms and personality traits in the pathogenesis of migraine.
Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer.
Meta-Prediction of MTHFR Gene Polymorphism Mutations and Associated Risk for Colorectal Cancer.
Methyl group metabolism gene polymorphisms and susceptibility to prostatic carcinoma.
Methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in chronic myeloid leukemia: an Egyptian study.
Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer.
Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms as risk factors for hepatocellular carcinoma in a Korean population.
Methylenetetrahydrofolate reductase (MTHFR) and susceptibility for (pre)neoplastic cervical disease.
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases.
Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T, A1298C and G1793A Polymorphisms: Association with Risk for Clear Cell Renal Cell Carcinoma and Tumour Behaviour in Men.
Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia.
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and promoter methylation in cervical oncogenic lesions and cancer.
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia.
Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: a population-based case-control study.
Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer.
Methylenetetrahydrofolate reductase (MTHFR): a novel target for cancer therapy.
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and risk of proximal colon cancer in north Italy.
Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides.
Methylenetetrahydrofolate Reductase A1298C Polymorphism and Breast Cancer Risk: A Meta-analysis of 33 Studies.
Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype.
Methylenetetrahydrofolate reductase C667T polymorphism is associated with increased risk of coronary artery disease in a Chinese population.
Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms in oral squamous cell carcinoma in south-east Iran.
Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: association with toxicity and survival.
Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients.
Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status.
Methylenetetrahydrofolate reductase C677T is not associated with expression of pyrimidine metabolic enzyme genes in colorectal cancer.
Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to cervical cancer and cervical intraepithelial neoplasia: a meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients.
Methylenetetrahydrofolate reductase gene polymorphisms in 13 Chinese ethnic populations.
Methylenetetrahydrofolate reductase gene polymorphisms: association with risk for pediatric acute lymphoblastic leukemia in north Indians.
Methylenetetrahydrofolate reductase genotype does not play a role in multiple myeloma pathogenesis.
Methylenetetrahydrofolate reductase genotypes and haplotypes associated with susceptibility to colorectal cancer in an eastern Chinese Han population.
Methylenetetrahydrofolate reductase polymorphism C677T is not associated to the risk of cervical dysplasia.
Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy.
Methylenetetrahydrofolate reductase polymorphism, diet, and breast cancer in Korean women.
Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis.
Methylenetetrahydrofolate reductase polymorphisms and susceptibility to gastric cancer in Chinese populations: a meta-analysis.
Methylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated breast and ovarian cancer risks.
Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis.
Molecular phylogenetic analysis of methylenetetrahydrofolate reductase family of proteins.
MTHFR 677 (C-->T) polymorphism is not relevant for prognosis or therapy-associated toxicity in pediatric NHL: results from 484 patients of multicenter trial NHL-BFM 95.
MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic.
MTHFR C677 T gene polymorphism in lymphoproliferative diseases.
MTHFR C677T and A1298C polymorphisms and cervical carcinoma susceptibility: meta-analyses based on 4421 individuals.
MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review.
MTHFR C677T and A1298C variant genotypes and the risk of microsatellite instability among Iranian colorectal cancer patients.
MTHFR C677T has differential influence on risk of MSI and MSS colorectal cancer.
MTHFR C677T polymorphism and anatomopathological characteristics with prognostic significance in sporadic colorectal cancer.
MTHFR C677T polymorphism and differential methylation status in gastric cancer: an association with Helicobacter pylori infection.
MTHFR C677T polymorphism interaction with heavy alcohol consumption increases head and neck carcinoma risk.
MTHFR C677T Polymorphism is Associated with Tumor Response to Preoperative Chemoradiotherapy: A Result Based on Previous Reports.
MTHFR C677T polymorphism: association with lymphoid neoplasm and effect on methotrexate therapy.
MTHFR Gene Polymorphisms and Bladder Cancer Susceptibility: a Meta-Analysis Including Race, Smoking Status and Tumour Stage.
MTHFR Gene variants C677T, A1298C and association with Down syndrome: A Case-control study from South India.
MTHFR Knockdown Assists Cell Defense against Folate Depletion Induced Chromosome Segregation and Uracil Misincorporation in DNA.
MTHFR polymorphism and the risk of prostate cancer: a meta-analysis of case-control studies.
MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer.
MTHFR polymorphisms and risk of chronic lymphocytic leukemia.
MTHFR polymorphysms in myelodysplastic syndromes and therapy-related myeloid neoplasms.
MTHFR single nucleotide polymorphism associated with working memory in pediatric medulloblastoma survivors.
MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumors.
MTHFR/p53 polymorphisms as genetic factors for cervical intraepithelial neoplasia and cervical cancer in HPV-infected Mexican women.
Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms.
Multiplex PCR for simultaneous detection of 677 C-->T and 1298 A-->C polymorphisms in methylenetetrahydrofolate reductase gene for population studies of cancer risk.
Murine diet/tissue and human brain tumorigenesis alter Mthfr/MTHFR 5'-end methylation.
Mutational analysis of the MTHFR gene in breast cancer patients of Pakistani population.
NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells. Purification and properties.
No evidence of association of methylenetetrahydrofolate reductase polymorphism with occurrence of second neoplasms after treatment of childhood leukemia.
Novel insights into the development of portal vein thrombosis in cirrhosis patients.
Nutrition, genetics, and risks of cancer.
One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation.
Pancreaticobiliary cancers with deficient methylenetetrahydrofolate reductase genotypes.
Personalized Nutrition-Genes, Diet, and Related Interactive Parameters as Predictors of Cancer in Multiethnic Colorectal Cancer Families.
Pharmacogenetic Predictors of Outcome in Patients with Stage II and III Colon Cancer Treated with Oxaliplatin and Fluoropyrimidine-Based Adjuvant Chemotherapy.
Pharmacogenetic relevance of MTHFR polymorphisms.
Plasma B-vitamins and one-carbon metabolites and the risk of breast cancer in younger women.
Plasma homocysteine in patients with retinal vein occlusion.
Polymorphic methyl group metabolism genes in patients with transitional cell carcinoma of the urinary bladder.
Polymorphism in ADH and MTHFR genes in oral squamous cell carcinoma of Indians.
Polymorphisms in Genes Involved in Folate Metabolism Modify the Association of Dietary and Circulating Folate and Vitamin B-6 with Cervical Neoplasia.
Polymorphisms in methylenetetrahydrofolate reductase and cystathionine beta-synthase in oral cancer - a case-control study in southeastern Brazilians.
Polymorphisms in MTHFR, MTR, RFC1 and CßS genes involved in folate metabolism and thyroid cancer: a case-control study.
Polymorphisms in the methylenetetrahydrofolate reductase gene and prostate cancer risk.
Polymorphisms in the MTHFR gene are associated with recurrence risk in lymph node-positive breast cancer patients.
Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking.
Polymorphisms of 5,10-methylenetetralydrofolate reductase (MTHFR), fruit and vegetable intake, and the risk of stomach cancer.
Polymorphisms of Folate Pathway Enzymes (Methylenetetrahydrofolate Reductase and Thymidylate Synthase) and Their Relationship with Thymidylate Synthase Expression in Human Astrocytic Tumors.
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population.
Polymorphisms of methylenetetrahydrofolate reductase and the risk of prostate cancer: a nested case-control study.
Polymorphisms of MTHFR and susceptibility to oesophageal adenocarcinoma in a Caucasian United Kingdom population.
Polymorphisms of MTHFR Associated with Higher Relapse/Death Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies.
Preliminary assessment of differential expression of candidate genes associated with atherosclerosis.
Presence of the methylenetetrahydrofolate reductase gene polymorphism MTHFR C677T in molar tissue but not maternal blood predicts failure of methotrexate treatment for low-risk gestational trophoblastic neoplasia.
Prevalence of factor V Leiden, FII G20210A, FXIII Val34Leu and MTHFR C677T polymorphisms in cancer patients with and without venous thrombosis.
Prevalence of thrombophilic genetic factors among patients with retinitis pigmentosa.
Preventive medical services not covered by public health insurance at Daiko Medical Center in Japan, 2004-2011.
Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin status.
Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors.
Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors.
Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency.
Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).
Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes and prostate cancer risk and aggressiveness.
Relationship between MTHFR Gene Polymorphisms and Gastrointestinal Tumors Development: Perspective from Eastern Part of Turkey.
Relevance of MTHFR polymorphisms with response to fluoropyrimidine-based chemotherapy in oesophagogastric cancer: a meta-analysis.
Risk association of meningiomas with MTHFR C677T and GSTs polymorphisms: a meta-analysis.
Risk factors for colon cancer in Northeastern Thailand: interaction of MTHFR codon 677 and 1298 genotypes with environmental factors.
Risk factors for rectal cancer and methylenetetrahydrofolate reductase polymorphisms in a population in Northeast Thailand.
Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population.
Role of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies.
Role of MTHFR polymorphisms and folate levels in different phenotypes of sporadic colorectal cancers.
Role of the MTHFR polymorphisms in cancer risk modification and treatment.
Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives.
Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate.
Statistical Correlations of the Spontaneous Abortion with Trombophilia and Other Associated Pathologies.
Study on Relationships of Tumor Status and Gene Polymorphism With Blood Concentration of MTX and Toxicities in 63 Pediatric Mature B Cell Lymphoma in Chinese Population.
The 19-bp deletion of dihydrofolate reductase (DHFR), methylenetetrahydrofolate reductase (MTHFR) C677T, Factor V Leiden, prothrombin G20210A polymorphisms in cancer patients with and without thrombosis.
The activities of the NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells are kinetically independent.
The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer.
The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia.
The association between MTHFR C677T polymorphism and ovarian cancer risk: a meta-analysis of 18, 628 individuals.
The association between MTHFR polymorphism and cervical cancer.
The association between the C677T polymorphism in MTHFR gene and the risk of thyroid cancer: a meta-analysis.
The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition.
The Association of Protease Activated Receptor 1 gene -506 I/D Polymorphism with Disease-Free Survival in Breast Cancer Patients.
The combination of methylenehydrofolate reductase C677T polymorphism screening and gastrointestinal tumor markers detection may be an early screening method for gastrointestinal cancer related to helicobacter pylori infection.
The common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk.
The effect of folate-related SNPs on clinicopathological features, response to neoadjuvant treatment and survival in pre- and postmenopausal breast cancer patients.
The effect of methylenetetrahydrofolate reductase polymorphism C677T on cervical cancer in Korean women.
The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women.
The expression of mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase supports a role in rapid cell growth.
The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase.
The genomic basis of cerebral palsy: a HuGE systematic literature review.
The human and mouse methylenetetrahydrofolate reductase (MTHFR) genes: genomic organization, mRNA structure and linkage to the CLCN6 gene.
The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women.
The Impact of MTHFR 1298 A?>?C and 677 C?>?T Gene Polymorphisms as Susceptibility Risk Factors in Cervical Intraepithelial Neoplasia Related to HPV and Sexually Transmitted Infections.
The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiforme.
The methylenetetrahydrofolate reductase (MTHFR) 677 C>T polymorphism increases the risk of developing chronic myeloid leukemia-a case-control study.
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China.
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: the Croatian case-control study.
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and tumor risk: evidence from 134 case-control studies.
The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: role in tumor development and significance of allelic loss in tumor progression.
The methylenetetrahydrofolate reductase 677C-->T polymorphism and lung cancer risk in a Chinese population.
The methylenetetrahydrofolate reductase 677T-1298C haplotype is a risk factor for acute lymphoblastic leukemia in children.
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.
The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lymphocytes.
The MTHFR 677C-->T polymorphism and risk of prostate cancer: results from the CAPS study.
The MTHFR C677T and DeltaDNMT3B C-149T polymorphisms confer different risks for right- and left-sided colorectal cancer.
The NADP-dependent trifunctional methylenetetrahydrofolate dehydrogenase purified from mouse liver is immunologically distinct from the mouse NAD-dependent [corrected] bifunctional enzyme.
The protective effect of methylenetetrahydrofolate reductase C677T polymorphism against prostate cancer risk: Evidence from 23 case-control studies.
The protective effects of the methylenetetrahydrofolate reductase rs1801131 variant among Saudi smokers.
The role of MTHFR and RFC1 polymorphisms on toxicity and outcome of adult patients with hematological malignancies treated with high-dose methotrexate followed by leucovorin rescue.
The role of the MTHFR 677C>T polymorphism in methotrexate-induced liver toxicity: a meta-analysis in patients with cancer.
Thrombophilic polymorphisms in preterm delivery.
Thymidylate synthase and methylenetetrahy-drofolate reductase gene polymorphisms and gastric cancer susceptibility in a population of Northern Brazil.
Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity.
TYMS, MTHFR, p53 and MDR1 gene polymorphisms in breast cancer patients treated with adjuvant therapy.
Update on cobalamin, folate, and homocysteine.
Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are less likely to have cervical intraepithelial neoplasia (CIN) 2 or 3.
[Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of breast cancer]
[Association between genetic variations in methylenetetrahydrofolate reductase and risk of colorectal cancer in a Chinese population]
[Clinical significance of thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in Korean patients with gastric cancer]
[Folate and cancer]
[Justifying genetic and immune markers of efficiency and sensitivity under combined exposure to risk factors in mining industry workers].
[Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia].
[Prediction of response to neoadjuvant chemotherapy in Barrett's carcinoma by quantitative gene expression analysis]
[Promoters of genes MTHFR from patients with hyperhomocysteinemia and PTEN from patients with malignant and benign endometrial and ovarian tumors]
[Single nucleotide polymorphisms in methylenetetrahydrofolate reductase gene and susceptibility to cancer of the gastric cardia in Chinese population]
[The relationship between methylenetetrahydrofolate reductase gene polymorphism and microsatellite instability in gastric cancer]
Neoplasms, Second Primary
No evidence of association of methylenetetrahydrofolate reductase polymorphism with occurrence of second neoplasms after treatment of childhood leukemia.
Neoplasms, Squamous Cell
Influence of MTHFR Genetic Background on p16 and MGMT Methylation in Oral Squamous Cell Cancer.
Nephritis
[Prognostic value of allelic variants affecting the hemostatic system in the development of antiphospholipid syndrome and kidney lesion in patients with systemic lupus erythematosus].
Nephrosclerosis
Methylenetetrahydrofolate reductase (MTHFR) polymorphism A1298C (Glu429Ala) predicts decline in renal function over time in the African-American Study of Kidney Disease and Hypertension (AASK) Trial and Veterans Affairs Hypertension Cohort (VAHC).
The MTHFR 677TT and 677CT/1298AC genotypes in Cypriot patients may be predisposing to hypertensive nephrosclerosis and chronic renal failure.
Nephrotic Syndrome
Arterial thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase C677T mutation in childhood membranous glomerulonephritis.
Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase A1298C mutation in adult membranous glomerulonephritis.
Methylenetetrahydrofolate reductase gene polymorphisms in patients with nephrotic syndrome.
Nervous System Diseases
Association between MTHFR Gene Polymorphisms and the Risk of Autism Spectrum Disorders: A Meta-Analysis.
Methylenetetrahydrofolate Reductase A1298C Polymorphism and Breast Cancer Risk: A Meta-analysis of 33 Studies.
Microarray analysis of brain RNA in mice with methylenetetrahydrofolate reductase deficiency and hyperhomocysteinemia.
The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction.
Neural Tube Defects
"Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis"
5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects.
677-->CT mutation on the methylenetetrahydrofolate reductase gene is not a risk factor for neural tube defects in Turkey.
A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects.
A1298C polymorphism of the MTHFR gene and neural tube defects in the state of Yucatan, Mexico.
Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect.
Acrania, MTHFR 677C-->T mutation and role of folate intake.
Adaptive developmental plasticity in methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism limits its frequency in South Indians.
Amniotic fluid homocysteine levels, 5,10-methylenetetrahydrafolate reductase genotypes, and neural tube closure sites.
Analysis of MTHFR 1298A>C in addition to MTHFR 677C>T polymorphism as a risk factor for neural tube defects in the Turkish population.
Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects.
Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies.
Association between Fetal MTHFR A1298C (rs1801131) Polymorphism and Neural Tube Defects Risk: A Systematic Review and Meta-Analysis.
Association between MTHFR A1298C polymorphism and neural tube defect susceptibility: a metaanalysis.
Association between MTHFR C677T polymorphism and neural tube defect risks: A comprehensive evaluation in three groups of NTD patients, mothers, and fathers.
Association of congenital cardiac defects and the C677T methylenetetrahydrofolate reductase polymorphism.
Association of Fetal MTHFR C677T Polymorphism with Susceptibility to Neural Tube Defects: A Systematic Review and Update Meta-Analysis.
Association of FOLH1, DHFR, and MTHFR gene polymorphisms with susceptibility of Neural Tube Defects: A case control study from Eastern India.
Association of methylenetetrahydrofolate reductase genetic polymorphisms with atlantoaxial dislocation.
Association of MTHFR C677T, MTHFR A1298C, and MTRR A66G Polymorphisms with Neural Tube Defects in Tunisian Parents.
Association of neural tube defects in children of mothers with MTHFR 677TT genotype and abnormal carbohydrate metabolism risk: a case-control study.
Association of the 677C-->T mutation on the methylenetetrahydrofolate reductase gene in Turkish patients with neural tube defects.
Association of the C677T methylenetetrahydrofolate reductase mutation and elevated homocysteine levels with congenital cardiac malformations.
Association of the maternal MTHFR C677T polymorphism with susceptibility to neural tube defects in offsprings: evidence from 25 case-control studies.
Associations between prenatal exposure to cadmium and lead with neural tube defect risks are modified by single-nucleotide polymorphisms of fetal MTHFR and SOD2: a case-control study.
Bladder exstrophy-epispadias complex and the role of methylenetetrahydrofolate reductase C677T polymorphism: A case control study.
Bringing clarity to the role of MTHFR variants in neural tube defect prevention.
C677T mutation in methylenetetrahydrofolate reductase gene and neural tube defects: should Japanese women undergo gene screening before pregnancy?
C677T mutation of the methylenetetrahydrofolate reductase gene among the Korean infants in Seoul city.
C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses.
C677T polymorphism of the methylenetetrahydrofolate reductase gene does not affect folic acid, vitamin B12, and homocysteine serum levels in Turkish children with neural tube defects.
Characterization of a pseudogene for murine methylenetetrahydrofolate reductase.
Correction to: Associations between prenatal exposure to cadmium and lead with neural tube defect risks are modified by single-nucleotide polymorphisms of fetal MTHFR and SOD2: a case-control study.
Determining the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and genomic DNA methylation level: A meta-analysis.
Drug and environmental factors associated with adverse pregnancy outcomes. Part III: Folic acid: pharmacology, therapeutic recommendations, and economics.
Easy detection of 5,10-methylenetetrahydrofolate reductase 1298A/C genotype by mutagenically separated PCR assay.
Effects of Periconceptional Multivitamin Supplementation on Folate and Homocysteine Levels Depending on Genetic Variants of Methyltetrahydrofolate Reductase in Infertile Japanese Women.
Epigenetic profiles in children with a neural tube defect; a case-control study in two populations.
Erratum to: Variants in maternal COMT and MTHFR genes and risk of neural tube defects in offspring.
Erythrocyte volume, folate levels, and the presence of methylenetetrahydrofolate reductase polymorphism.
Evaluation of maternal serum folate, vitamin B12, and homocysteine levels andfactor V Leiden, factor II g.20210G>A, and MTHFR variations in prenatallydiagnosed neural tube defects.
Folate supplementation, MTHFR gene polymorphism and neural tube defects: a community based case control study in North India.
Frequency of the thermolabile variant C677T in the MTHFR gene and lack of association with neural tube defects in the State of Yucatan, Mexico.
Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae.
Gene-gene interaction between the cystathionine beta-synthase 31 base pair variable number of tandem repeats and the methylenetetrahydrofolate reductase 677C > T polymorphism on homocysteine levels and risk for neural tube defects.
Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects.
High prevalence of the thermolabile methylenetetrahydrofolate reductase variant in Mexico: a country with a very high prevalence of neural tube defects.
Hyperhomocysteinemia in men with a reproductive history of fetal neural tube defects: Three case reports and literature review.
Imaging and genetic investigations of neural tube defect in a calf: case report and review of the literature.
Impact of methylenetetrahydrofolate reductase deficiency and low dietary folate on the development of neural tube defects in splotch mice.
Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study.
In human alleles specific variation of MTHFR C677T and A1298C associated "risk factor" for the development of ovarian cancer.
Infant C677T mutation in MTHFR, maternal periconceptional vitamin use, and cleft lip.
Infant methylenetetrahydrofolate reductase 677TT genotype is a risk factor for congenital heart disease.
Insights on the structural perturbations in human MTHFR Ala222Val mutant by protein modeling and molecular dynamics.
Lifestyle, metabolite, and genetic determinants of formate concentrations in a cross-sectional study in young, healthy adults.
Low maternal folate concentrations and maternal MTHFR C677T polymorphism are associated with an increased risk for neural tube defects in offspring: a case-control study among Pakistani case and control mothers.
Maternal one-carbon metabolism, MTHFR and TCN2 genotypes and neural tube defects in India.
Metabolic effects and the methylenetetrahydrofolate reductase (MTHFR) polymorphism associated with neural tube defects in southern Brazil.
Metabolic effects of C677T and A1298C mutations at the MTHFR gene in Brazilian children with neural tube defects.
Methylenetetrahydrofolate reductase (MTHFR) deficiency enhances resistance against cytomegalovirus infection.
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms resulting in suboptimal oocyte maturation: a discussion of folate status, neural tube defects, schizophrenia, and vasculopathy.
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia.
Methylenetetrahydrofolate reductase and neural tube defects.
Methylenetetrahydrofolate reductase gene polymorphisms and neural tube defects epidemiology in the Slovak population.
Methylenetetrahydrofolate reductase gene polymorphisms and the risk of anencephaly in Mexico.
Methylenetetrahydrofolate reductase mutation and neural tube defects.
Methylenetetrahydrofolate reductase mutations, a genetic cause for familial recurrent neural tube defects.
Methylenetetrahydrofolate reductase thermolabile variant and oral clefts.
Molecular beacons: a new approach for semiautomated mutation analysis.
Molecular phylogenetic analysis of methylenetetrahydrofolate reductase family of proteins.
MTHFR 677 TT genotype in a mother and her child with Down syndrome, atrioventricular canal and exstrophy of the bladder: implications of a mutual genetic risk factor?
MTHFR 677C-->T and 1298A-->C polymorphisms: evaluation of maternal genotypic risk and association with level of neural tube defect.
MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation.
MTHFR C677T and A1298C variants in Mexican Mestizo infants with neural tube defects from Western Mexico.
MTHFR C677T polymorphism as a risk factor of neural tube defects in Malay: a case control study.
MTHFR genetic testing: Controversy and clinical implications.
Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms.
Mutational landscape screening of methylene tetrahydrofolate reductase to predict homocystinuria associated variants: An integrative computational approach.
Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations.
Neural tube defects, methylenetetrahydrofolate reductase mutation, and north/south dietary differences in China.
Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences.
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population.
Possible interaction of genotypes at cystathionine beta-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects. NTD Collaborative Group.
Presence of the 5,10-methylenetetrahydrofolate reductase C677T mutation in Puerto Rican patients with neural tube defects.
Retrospective approach to methylenetetrahydrofolate reductase mutations in children.
Role of amniotic fluid homocysteine level and of fetal 5, 10-methylenetetrahydrafolate reductase genotype in the etiology of neural tube defects.
Role of parental folate pathway single nucleotide polymorphisms in altering the susceptibility to neural tube defects in South India.
Screening of the C677T mutation on the methylenetetrahydrofolate reductase gene in French patients with neural tube defects.
Semiautomated DNA mutation analysis using a robotic workstation and molecular beacons.
Sequential multiple retinal vein occlusions and transient ischemic attack in MTHFR polymorphism and protein S deficiency.
Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR.
Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population.
Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation.
Testing for genetic association with constrained models using triads.
The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother.
The association between maternal methylenetetrahydrofolate reductase C677T and A1298C polymorphism and birth defects and adverse pregnancy outcomes.
The C677T mutation in the methylenetetrahydrofolate reductase gene among the Indonesian Javanese population.
The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr.
The influence of 5,10 methylenetetrahydrofolate reductase genotypes on enzyme activity in placental tissue.
The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot.
The relation between erythrocyte volume and folate levels is influenced by a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T).
The thermolabile variant 677C-->T can further reduce activity when expressed in cis with severe mutations for human methylenetetrahydrofolate reductase.
The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group.
Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans.
Unique holoenzyme dimers of the tetrameric enzyme Escherichia coli methylenetetrahydrofolate reductase: characterization of structural features associated with modulation of the enzyme's function.
Updated investigations of the role of methylenetetrahydrofolate reductase in human neural tube defects.
Variants in maternal COMT and MTHFR genes and risk of neural tube defects in offspring.
Variants in MTHFR gene and neural tube defects susceptibility in China.
[C677T and A1298C MTHFR polymorphisms in the etiology of neural tube defects in Spanish population]
[Geographical distribution characteristics of one carbon metabolic pathway related single nucleotide polymorphisms].
[Hyperhomocysteinemia and pregnancy complications]
[Meta-analysis on relationship between the Chinese maternal MTHFR gene polymorphism(C677T) and neural tube defects in offspring].
[Mutations of MTHFR, MTR, MTRR genes as high risk factors for neural tube defects]
[Polymorphism of the methylenetetrahydrofolate reductase gene (MTHFR) and incidence of hyperhomocysteinemia-related diseases]
[The common C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with neural tube defects and preeclampsia]
[The significance of folate metabolism in complications of pregnant women].
Neuroblastoma
Antisense inhibition of methylenetetrahydrofolate reductase reduces cancer cell survival in vitro and tumor growth in vivo.
MTHFR and VDR Polymorphisms Improve the Prognostic Value of MYCN Status on Overall Survival in Neuroblastoma Patients.
Reduced folate carrier-1 G80a gene polymorphism is associated with neuroblastoma's development.
RFC-1 80G>A Polymorphism in Case-Mother/Control-Mother Dyads Is Associated with Risk of Nephroblastoma and Neuroblastoma.
Neurodegenerative Diseases
Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in patients with essential tremor in Turkey.
Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population.
Genetic variation in the methylenetetrahydrofolate reductase gene, MTHFR, does not alter the risk of visual failure in Leber's hereditary optic neuropathy.
Genetics and Epigenetics of One-Carbon Metabolism Pathway in Autism Spectrum Disorder: A Sex-Specific Brain Epigenome?
Mthfr as a modifier of the retinal phenotype of Crb1(rd8/rd8) mice.
Neurofibroma
Are the methylenetetrahydrofolate reductase 1298 and 677 gene polymorphisms related to optic glioma and hamartoma risk in neurofibromatosis type 1 patients?
Neurofibromatoses
Are the methylenetetrahydrofolate reductase 1298 and 677 gene polymorphisms related to optic glioma and hamartoma risk in neurofibromatosis type 1 patients?
Coexistence of Neurofibromatosis Type-1 and MTHFR C677T Gene Mutation in a Young Stroke Patient: A Case Report.
Neurofibromatosis 1
Are the methylenetetrahydrofolate reductase 1298 and 677 gene polymorphisms related to optic glioma and hamartoma risk in neurofibromatosis type 1 patients?
Neurologic Manifestations
A newborn case with perinatal-lethal Gaucher disease due to R463H homozygosity complicated by C677T homozygosity in the MTHFR gene.
Methylenetetrahydrofolate reductase (MTHFR) deficiency and infantile epilepsy.
Neuronal Ceroid-Lipofuscinoses
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Neurotoxicity Syndromes
Toxic encephalopathy and delayed MTX clearance after high-dose methotrexate therapy in a child homozygous for the MTHFR C677T polymorphism.
Neutropenia
Association of C677T and A1298C MTHFR Polymorphisms and Fluoropyrimidine-induced Toxicity in Mestizo Patients With Metastatic Colorectal Cancer.
Correlation Between Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphisms and Pemetrexed Chemotherapy Efficacy/Toxicity in Non-Squamous Non-Small Cell Lung Cancer.
DPYD*2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer.
Folate pathway genetic polymorphisms modulate methotrexate-induced toxicity in childhood acute lymphoblastic leukemia.
Gene-Gene Interactions of Gemcitabine Metabolizing-Enzyme Genes hCNT3 and WEE1 for Preventing Severe Gemcitabine-Induced Hematological Toxicity.
Influence of chemotherapeutic drug-related gene polymorphisms on toxicity and survival of early breast cancer patients receiving adjuvant chemotherapy.
Pharmacogenetic studies in children with acute lymphoblastic leukemia in Argentina.
Study on Relationships of Tumor Status and Gene Polymorphism With Blood Concentration of MTX and Toxicities in 63 Pediatric Mature B Cell Lymphoma in Chinese Population.
Niemann-Pick Diseases
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Non-alcoholic Fatty Liver Disease
Associations between Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms and Non-Alcoholic Fatty Liver Disease (NAFLD) Risk: A Meta-Analysis.
Methylenetetrahydrofolate reductase C677T mutation and nonalcoholic fatty liver disease.
Methylenetetrahydrofolate Reductase Gene Polymorphism and Serum Homocysteine Levels in Nonalcoholic Fatty Liver Disease.
Methylenetetrahydrofolate reductase gene polymorphisms in patients with nonalcoholic steatohepatitis (NASH).
MiR-149 Compromises the Reactions of Liver Cells to Fatty Acid via its Polymorphism and Increases Non-Alcoholic Fatty Liver Disease (NAFLD) Risk by Targeting Methylene Tetrahydrofolate Reductase (MTHFR).
MTHFR 677C/T and 1298A/C mutations and non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) and MTHFR 1298A > C gene polymorphism.
Plasmatic higher levels of homocysteine in non-alcoholic fatty liver disease (NAFLD).
The methylenetetrahydrofolate reductase genotype 677CT and non-alcoholic fatty liver disease have a synergistic effect on the increasing homocysteine levels in subjects from Chongqing, China.
[C677T AND A1298C ALLELE POLYMORPHISM GENE OF METHYLENETETRAHYDRAFOLATEREDUCTASE IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE AND TYPE 2 DIABETES].
[Progress in the Management of NAFLD/NASH].
Obesity
A comparison of the genetic and clinical risk factors for arterial hypertension between indigenous and non-indigenous people of the Shoria Mountain Region.
A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia.
Acid folic and pregnancy: A mandatory supplementation.
Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity?
Association of Methylene Tetrahydrofolate Reductase C677T Genotype With Type 2 Diabetes Mellitus Patients With and Without Renal Complications.
Association of MTHFR genetic polymorphisms with venous thromboembolism in Uyghur population in Xinjiang, China.
Association of the MTHFR 677C>T Polymorphism with Obesity and Biochemical Variables in a Young Population of Mexico.
C677T gene polymorphism of MTHFR and metabolic syndrome: response to dietary intervention.
Common polymorphisms in six genes of the methyl group metabolism pathway and obesity in European adolescents.
Effect of maternal folic acid supplementation on hepatic one-carbon unit associated gene expressions in newborn piglets.
Effect of MTHFR (rs1801133) and FTO (rs9939609) genetic polymorphisms and obesity in T2DM: a study among Bengalee Hindu caste population of West Bengal, India.
Effects of a high-fat-sucrose diet on enzymes in homocysteine metabolism in the rat.
Elite athletes¿ genetic predisposition for altered risk of complex metabolic traits.
Gene-gene interactions and associations of six hypertension related single nucleotide polymorphisms with obesity risk in a Chinese children population.
Influence of the C677T Polymorphism of the MTHFR Gene on Oxidative Stress in Women With Overweight or Obesity: Response to a Dietary Folate Intervention.
Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya.
Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study.
Methylene tetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms related to overweight/obesity among Saudi subjects from Qassim Region.
Methylenetetrahydrofolate reductase gene polymorphism in diabetes and obesity.
Plausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization.
Polymorphisms of the FTO and MTHFR genes and vascular, inflammatory and metabolic marker levels in postmenopausal women.
Recurrent cerebral venous thrombosis associated with heterozygote methylenetetrahydrofolate reductase C677T mutation and sickle cell trait without homocysteinemia: an autopsy case report and review of literature.
Risk Factors for Thrombosis Development in Mexican Patients.
Single Nucleotide Polymorphisms in PEMT and MTHFR Genes are Associated with Omega 3 and 6 Fatty Acid Levels in the Red Blood Cells of Children with Obesity.
The association of MTHFR C677T gene variants and lipid profiles or body mass index in patients with diabetic and nondiabetic coronary heart disease.
The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts.
The MTHFR gene polymorphism is associated with lean body mass but not fat body mass.
Variant alleles in factor V, prothrombin, plasminogen activator inhibitor-1, methylenetetrahydrofolate reductase and risk of thromboembolism in metastatic colorectal cancer patients treated with first-line chemotherapy plus bevacizumab.
[Arterial Hypertension and Methylenetetrahydrofolate Reductase C677T Gene Polymorphism].
[FETAL LOSSES DURING THE MATURATION OF THE PLACENTA AND THE RELATIONSHIP WITH SOME PROCOAGULANT CONDITIONS.]
[Remodeling of the cardiovascular system and development of chronic kidney disease in patients with metabolic syndrome and obesity: role of eNOS, subunit p22-phox of NADPH-oxidase and MTHFR genes].
Obesity, Abdominal
Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in a patient with coronary artery disease and repetitive miscarriages.
Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya.
Metabolic factors and chronic hepatitis C: a complex interplay.
Obesity, Morbid
Thrombosis Related ABO, F5, MTHFR, and FGG Gene Polymorphisms in Morbidly Obese Patients.
Obstetric Labor, Premature
Pulmonary embolism and premature labor in a patient with both factor V Leiden mutation and methylenetetrahydrofolate reductase gene C677T mutation.
Oligospermia
Association of the MTHFR A1298C variant with unexplained severe male infertility.
Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility.
Correlation between methylenetetrahydrofolate reductase gene polymorphism and oligoasthenospermia and the effects of folic acid supplementation on semen quality.
Effect of B9 and B12 vitamin intake on semen parameters and fertility of men with MTHFR polymorphisms.
Effects of folic acid on oligozoospermia with MTHFR polymorphisms in term of seminal parameters, DNA fragmentation, and live birth rate: a double-blind, randomized, placebo-controlled trial.
Influence of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms in Algerian Infertile Men with Azoospermia or Severe Oligozoospermia.
Methylation Status of MTHFR Promoter and Oligozoospermia Risk: An Epigenetic Study and in Silico Analysis.
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis.
Methylenetetrahydrofolate reductase polymorphisms are related to male infertility in Brazilian men.
Role of genetic mutations in folate-related enzyme genes on Male Infertility.
Single nucleotide polymorphism C677T in the methylenetetrahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia.
The relationship between methylenetetrahydrofolate reductase c.677TT genotype and oligozoospermia in infertile male patients living in the Trakya region of Turkey.
Opisthorchiasis
MTHFR Polymorphisms and Opisthorchis viverrini Infection: a Relationship with Increased Susceptibility to Cholangiocarcinoma in Thailand.
Optic Atrophy, Hereditary, Leber
Genetic variation in the methylenetetrahydrofolate reductase gene, MTHFR, does not alter the risk of visual failure in Leber's hereditary optic neuropathy.
Optic Nerve Diseases
Genetic variation in the methylenetetrahydrofolate reductase gene, MTHFR, does not alter the risk of visual failure in Leber's hereditary optic neuropathy.
Hyperhomocyst(e)inaemia, but not MTHFR C677T mutation, as a risk factor for non-arteritic ischaemic optic neuropathy.
Optic Nerve Glioma
Are the methylenetetrahydrofolate reductase 1298 and 677 gene polymorphisms related to optic glioma and hamartoma risk in neurofibromatosis type 1 patients?
Optic Neuropathy, Ischemic
Anterior ischemic optic neuropathy in a patient with Crohn's disease and aberrant MTHFR and GPIIIa gene variants.
Association Study of MTHFR Polymorphisms with Nonarteritic Anterior Ischemic Optic Neuropathy in a Spanish Population.
Hyperhomocyst(e)inaemia, but not MTHFR C677T mutation, as a risk factor for non-arteritic ischaemic optic neuropathy.
Nonarteritic anterior ischemic optic neuropathy: associations with homozygosity for the C677T methylenetetrahydrofolate reductase mutation.
Ocular vascular thrombotic events: a diagnostic window to familial thrombophilia (compound factor v leiden and prothrombin gene heterozygosity) and thrombosis.
Oral Ulcer
Association of MTHFR gene C677T mutation with recurrent aphthous stomatitis and number of oral ulcers.
ornithine aminotransferase deficiency
Targeted cerebrospinal fluid analysis for inborn errors of metabolism on an LC-MS/MS analysis platform.
Osteoarthritis
Factors predisposing to thrombosis after major joint arthroplasty.
MTHFR gene C677T mutation and ACE gene I/D polymorphism in Turkish patients with osteoarthritis.
Osteonecrosis
A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Association between MTHFR C677T polymorphism and osteonecrosis of the femoral head: a meta-analysis.
Association of corticosteroids and factor V, prothrombin, and MTHFR gene mutations with avascular osteonecrosis in renal allograft recipients.
Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head.
Genetic background of nontraumatic osteonecrosis of the femoral head in the korean population.
Genetic risk factors for glucocorticoid-induced osteonecrosis: A meta-analysis.
Lack of association of MTHFR gene polymorphisms with the risk of osteonecrosis of the femoral head in a Korean population.
Methylenetetrahydrofolate reductase gene polymorphism and glucocorticoid intake in children with ALL and aseptic osteonecrosis.
Osteoporosis
A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish osteoporosis prevention study.
Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish osteoporosis prevention study.
Association of MTHFR C677T polymorphism with bone mineral density of osteoporosis in postmenopausal Thai women.
Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C667T polymorphism, with bone mineral density in postmenopausal Iranian women: a cross-sectional study.
Association of the methylenetetrahydrofolate reductase C677T polymorphism and fracture risk in Chinese postmenopausal women.
Effect of MTHFR, TGF?1, and TNFB polymorphisms on osteoporosis in rheumatoid arthritis patients.
Genome-wide association with bone mass and geometry in the Framingham Heart Study.
Impact of genetic variation on metabolic response of bone to diet.
MTHFR C677T polymorphism and osteoporotic fractures.
MTHFR C677T, MTHFR A1298C, and OPG A163G polymorphisms in Mexican patients with rheumatoid arthritis and osteoporosis.
Pregnancy-associated osteoporosis with a heterozygous deactivating LDL receptor-related protein 5 (LRP5) mutation and a homozygous methylenetetrahydrofolate reductase (MTHFR) polymorphism.
The effects of homocysteine and MTHFR genotype on hip bone loss and fracture risk in elderly women.
[Polymorphisms in xenobiotic-metabolizing genes in the pathogenesis of glucocorticoid-induced osteoporosis in patients with bronchial asthma].
Osteoporosis, Postmenopausal
Association of the MTHFR C677T polymorphism and bone mineral density in postmenopausal women: a meta-analysis.
Osteosarcoma
Association of MTHFR and ABCB1 polymorphisms with MTX-induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma-A retrospective cohort study.
ATIC Gene Polymorphism and Histologic Response to Chemotherapy in Pediatric Osteosarcoma.
Impact of genetic variants of RFC1, DHFR and MTHFR in osteosarcoma patients treated with high-dose methotrexate.
Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients.
More severe toxicity of genetic polymorphisms on MTHFR activity in osteosarcoma patients treated with high-dose methotrexate.
MTHFR variant is associated with high-dose methotrexate-induced toxicity in the Chinese osteosarcoma patients.
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
The role of the MTHFR C677T polymorphism in methotrexate-induced toxicity in pediatric osteosarcoma patients.
Ovarian Hyperstimulation Syndrome
A case of ovarian hyperstimulation syndrome associated with the methylenetetrahydrofolate reductase mutation gene.
Ovarian Neoplasms
Association between MTHFR Gene Polymorphism and the Risk of Ovarian Cancer: A Meta-analysis of the Literature.
Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis.
ASSOCIATION OF MTHFR A1298C POLYMORPHISM WITH BREAST CANCER AND/OR OVARIAN CANCER RISK: AN UPDATED META-ANALYSIS.
Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study.
Association of the C677T polymorphism in the MTHFR gene with breast and/or ovarian cancer risk in Jewish women.
Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients.
Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities.
Folate and choline metabolism gene variants in relation to ovarian cancer risk in the Polish population.
Folate intake and methylenetetrahydrofolate reductase gene polymorphisms as predictive and prognostic biomarkers for ovarian cancer risk.
Folate intake and MTHFR polymorphism C677T is not associated with ovarian cancer risk: evidence from the meta-analysis.
Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene Ala222Val and susceptibility to ovary cancer: a systematic review and meta-analysis.
Homocysteinemia is inversely correlated with platelet count and directly correlated with sE- and sP-selectin levels in females homozygous for C677T methylenetetrahydrofolate reductase.
In human alleles specific variation of MTHFR C677T and A1298C associated "risk factor" for the development of ovarian cancer.
Lack of Significance of the BRCA2 Promoter Methylation Status in Different Genotypes of the MTHFR a1298c Polymorphism in Ovarian Cancer Cases in Iran.
Methylenetetrahydrofolate reductase gene polymorphisms as predictive and prognostic biomarkers in ovarian cancer risk.
Methylenetetrahydrofolate reductase gene polymorphisms in the risk of polycystic ovary syndrome and ovarian cancer.
Methylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated breast and ovarian cancer risks.
MTHFR A1298C polymorphism and ovarian cancer risk: a meta-analysis.
MTHFR C677T polymorphism and ovarian cancer risk: a meta-analysis.
MTHFR polymorphisms and ovarian cancer risk: a meta-analysis.
MTHFR polymorphisms in relation to ovarian cancer risk.
The association between MTHFR C677T polymorphism and ovarian cancer risk: a meta-analysis of 18, 628 individuals.
[No association between MTHFR 677C>T polymorphism and ovarian cancer risk in BRCA1 mutation carriers in Wielkopolska region].
Overweight
Association of the MTHFR 677C>T Polymorphism with Obesity and Biochemical Variables in a Young Population of Mexico.
Food Intervention with Folate Reduces TNF-? and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial.
Influence of the C677T Polymorphism of the MTHFR Gene on Oxidative Stress in Women With Overweight or Obesity: Response to a Dietary Folate Intervention.
Lack of association between methylenetetrahydrofolate reductase (MTHFR) C677T and ischaemic heart disease (IHD): family-based association study in a Spanish population.
Methylene tetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms related to overweight/obesity among Saudi subjects from Qassim Region.
Methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) in relation to homocysteine concentration in overweight and obese Thais.
Personalized Nutrition-Genes, Diet, and Related Interactive Parameters as Predictors of Cancer in Multiethnic Colorectal Cancer Families.
Pancreatic Neoplasms
Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk.
Association of MTHFR gene polymorphisms with pancreatic cancer: meta-analysis of 17 case-control studies.
Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects.
Effect of MTHFR Polymorphisms on Gastrointestinal Cancer Risk in Italy.
Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis.
Genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase and risk of pancreatic cancer.
MTHFR C677T polymorphism and pancreatic cancer risk: a meta-analysis.
MTHFR gene polymorphisms are not involved in pancreatic cancer risk: a meta-analysis.
MTHFR Polymorphisms and Pancreatic Cancer Risk: Lack of Evidence from a Meta-analysis.
Pancreaticobiliary cancers with deficient methylenetetrahydrofolate reductase genotypes.
[Study on the relations between genetic polymorphisms in methylenetetrahydrofolate reductase, methionine synthase and the risk of pancreatic cancer]
Pancreatitis, Chronic
Association of 5, 10- methylenetetrahydrofolate reductase C677T polymorphism in susceptibility to tropical chronic pancreatitis in north Indian population.
MTHFR C677T polymorphism in chronic pancreatitis and pancreatic adenocarcinoma.
Papilloma
Investigation of Methylenetetrahydrofolate Reductase C677T Polymorphism and Human Papilloma Virus Genotypes in Iranian Breast Cancer.
Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin status.
The effect of methylenetetrahydrofolate reductase polymorphisms on susceptibility to human papilloma virus infection and cervical cancer.
Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are less likely to have cervical intraepithelial neoplasia (CIN) 2 or 3.
Papillomavirus Infections
Lack of association between methylenetetrahydrofolate reductase C677T polymorphism, HPV infection and cervical intraepithelial neoplasia in Brazilian women.
Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia.
Paralysis
5,10-Methylenetetrahydrofolate reductase deficiency with progressive polyneuropathy in an infant.
Paraparesis
Complete clinical and functional recovery following low-dose methotrexate related paraparesis in a patient with compound c.1298A>C AND c.677C>T MTHFR polymorphism: A case report.
Paraparesis, Spastic
Mutations in MTHFR and POLG impaired activity of the mitochondrial respiratory chain in 46-year-old twins with spastic paraparesis.
Recessive spastic paraparesis associated with complex I deficiency due to MTHFR mutations.
Severe methylenetetrahydrofolate reductase deficiency: clinical clues to a potentially treatable cause of adult-onset hereditary spastic paraplegia.
Paraplegia
Adult-onset severe methylenetetrahydrofolate reductase deficiency characterized by reversible spastic paraplegia with a novel mutation.
Psychosis, paraplegia and coma revealing methylenetetrahydrofolate reductase deficiency in a 56-year-old woman.
Paresis
A case of portal vein thrombosis after laparoscopy-assisted splenectomy and cholecystectomy in a child.
MTHFR homozygous mutation and additional risk factors for cerebral infarction in a large Italian family.
Parkinson Disease
5,10-methylenetetrahydrofolate reductase C677T gene polymorphism can influence age at onset of Parkinson's disease.
Association Between MTHFR Genetic Polymorphism and Parkinson's Disease Susceptibility: A Meta-analysis.
Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease.
Association of MTHFR C677T with total homocysteine plasma levels and susceptibility to Parkinson's disease: a meta-analysis.
Association of MTHFR, MTR, and MTRR polymorphisms with Parkinson's disease among ethnic Chinese in Taiwan.
Association of the MTHFR rs1801131 and rs1801133 variants in sporadic Parkinson's disease patients.
Association of the rs1801133 variant in the MTHFR gene and sporadic Parkinson's disease.
Coenzyme Q10, Hyperhomocysteinemia and MTHFR C677T Polymorphism in Levodopa-treated Parkinson's Disease Patients.
Differences in MTHFR and LRRK2 variant's association with sporadic Parkinson's disease in Mexican Mestizos correlated to Native American ancestry.
Genetic causes of Parkinson's disease in the Maltese: a study of selected mutations in LRRK2, MTHFR, QDPR and SPR.
Homocysteine Level and Mechanisms of Injury in Parkinson's Disease as Related to MTHFR, MTR, and MTHFD1 Genes Polymorphisms and L-Dopa Treatment.
Homocysteine serum levels and MTHFR C677T genotype in patients with Parkinson's disease, with and without levodopa therapy.
Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in patients with Parkinson's disease.
Hypertrophy of IMC of carotid artery in Parkinson's disease is associated with L-DOPA, homocysteine, and MTHFR genotype.
Meta-analysis supports association of a functional SNP (rs1801133) in the MTHFR gene with Parkinson's disease.
Methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and susceptibility to Parkinson's disease: A meta-analysis.
Methylenetetrahydrofolate reductase C677T genotype and PD.
Methylenetetrahydrofolate reductase in Parkinson's disease.
Methylenetetrahydrofolate reductase polymorphisms and plasma homocysteine in levodopa-treated and non-treated Parkinson's disease patients.
MTHFR C677T and A1298C polymorphisms may contribute to the risk of Parkinson's disease: A meta-analysis of 19 studies.
MTHFR C677T polymorphism, folic acid and hyperhomocysteinemia in levodopa treated patients with Parkinson's disease.
MTHFR C677T variant reduces risk of sporadic Parkinson's disease in ethnic Chinese.
The MTHFR C677T polymorphism modifies age at onset in Parkinson's disease.
[Pharmacogenetics in Parkinson's disease treatment]
Parkinsonian Disorders
A case of vascular parkinsonism associated with hyperhomocysteinemia and methylenetetrahydrofolate reductase gene variant (C677T).
Pediatric Obesity
Common polymorphisms in six genes of the methyl group metabolism pathway and obesity in European adolescents.
Periodontitis
miR-9-1 gene methylation and DNMT3B (rs2424913) polymorphism may contribute to periodontitis.
Peripheral Arterial Disease
5,10-methylenetetrahydrofolate reductase C677T gene polymorphism and peripheral arterial disease: A meta-analysis.
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase.
Factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations are not associated with chronic limb ischemia: the Linz Peripheral Arterial Disease (LIPAD) study.
Hyperhomocysteinaemia is an independent risk factor of abdominal aortic aneurysm in a Chinese Han population.
Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study.
Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes.
Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHFR) C677T mutations: A case-control study and meta-analysis.
Peripheral Nervous System Diseases
Association of MTHFR gene C677T mutation with diabetic peripheral neuropathy and diabetic retinopathy.
Effect of betaine on S-adenosylmethionine levels in the cerebrospinal fluid in a patient with methylenetetrahydrofolate reductase deficiency and peripheral neuropathy.
Effects of Common Polymorphisms in the MTHFR and ACE Genes on Diabetic Peripheral Neuropathy Progression: a Meta-Analysis.
Insidious peripheral neuropathy occurring under treatment in infantile MTHFR deficiency.
Is the C677T polymorphism in methylenetetrahydrofolate reductase gene or plasma homocysteine a risk factor for diabetic peripheral neuropathy in Chinese individuals?
Role of treatment-modifying MTHFR677C>T and 1298A>C polymorphisms in metformin-treated Puerto Rican patients with type-2 diabetes mellitus and peripheral neuropathy.
Peripheral Vascular Diseases
Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies.
Methylenetetrahydrofolate reductase gene and coronary artery disease.
MTHFR C677T Polymorphism as a Risk Factor for Vascular Calcification in Chronic Hemodialysis Patients.
Peripheral Vascular Disease Susceptibility Based on Diabetes Mellitus and rs17367504 Polymorphism of the MTHFR Gene.
Phenylketonurias
Subacute onset leukodystrophy and visual-spatial disorders revealing phenylketonuria combined with homocysteinmia in adulthood: A case report.
Placenta Accreta
Severe toxic effects of low-dose methotrexate treatment for placenta accreta in a patient with methylenetetrahydrofolate reductase mutations.
Placenta Diseases
[Hyperhomocysteinemia and pregnancy complications]
Placenta Previa
Anesthesia for cesarean section in a patient with placenta previa and methylenetetrahydrofolate reductase deficiency.
plasmin deficiency
Causes of venous thrombosis in fifty Chinese patients.
Protein C and protein S deficiencies are the most important risk factors associated with thrombosis in Chinese venous thrombophilic patients in Taiwan.
Pneumonia, Mycoplasma
Posterior cerebral artery occlusion after Mycoplasma pneumoniae infection associated with genetic defect of MTHFR C677T.
Polyarteritis Nodosa
Co-existence of renovascular hypertension, polyarteritis nodosa, antiphospholipid syndrome and methylenetetrahydrofolate reductase mutation.
Polycystic Ovary Syndrome
A meta-analysis on associations of FTO, MTHFR and TCF7L2 polymorphisms with polycystic ovary syndrome.
Association between a single nucleotide polymorphism in MTHFR gene and polycystic ovary syndrome.
Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with genetic susceptibility to polycystic ovary syndrome: A PRISMA-compliant meta-analysis.
Association of methylenetetrahydrofolate reductase gene C677T polymorphism with polycystic ovary syndrome risk: a systematic review and meta-analysis update.
Association of three missense mutations in the homocysteine-related MTHFR and MTRR gene with risk of polycystic ovary syndrome in Southern Chinese women.
Can the genetic polymorphisms of the folate metabolism have an influence in the polycystic ovary syndrome?
Genetic polymorphism of Methylenetetrahydrofolate reductase is associated with insulin resistance in Egyptian women with polycystic ovary syndrome.
Homocysteine levels and C677T polymorphism of methylenetetrahydrofolate reductase in women with polycystic ovary syndrome.
Is MTHFR 677 C>T Polymorphism Clinically Important in Polycystic Ovarian Syndrome (PCOS)? A Case-Control Study, Meta-Analysis and Trial Sequential Analysis.
Methylenetetrahydrofolate reductase C677T gene polymorphism in turkish patients with polycystic ovary syndrome.
Methylenetetrahydrofolate reductase C677T polymorphism and the risks of polycystic ovary syndrome: an updated meta-analysis of 14 studies.
Methylenetetrahydrofolate reductase gene polymorphisms in the risk of polycystic ovary syndrome and ovarian cancer.
MTHFR C 677T mutation and 4G/5G PAI-1 polymorphism in patient with polycystic ovarian syndrome.
MTHFR C677T polymorphism is associated with hyperlipidemia in women with polycystic ovary syndrome.
Note of clarification of data in the meta-analysis of methylenetetrahydrofolate reductase C677T polymorphisms in polycystic ovary syndrome.
Plasminogen Activator Inhibitor 1 and Methylenetetrahydrofolate Reductase Gene mutations in Iranian Women with Polycystic Ovary Syndrome.
Plasminogen activator inhibitor-1 4G/5G and the MTHFR 677C/T polymorphisms and susceptibility to polycystic ovary syndrome: a meta-analysis.
Polycystic ovary syndrome and the single nucleotide polymorphisms of methylenetetrahydrofolate reductase: a pilot observational study.
Prevalence of Methylenetetrahydrofolate Reductase C677T Polymorphism in women with Polycystic Ovary Syndrome in southeast of Iran.
Role of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in polycystic ovary syndrome risk.
Significant association between methylenetetrahydrofolate reductase gene C677T polymorphism with polycystic ovary syndrome risk: A meta-analysis update.
Thyroid vein thrombosis in a young woman with methylenetetrahydrofolate reductase gene mutation receiving cyproterone acetate/ethinylestradiol treatment for polycystic ovary syndrome: a case report.
Variant Alleles of the ESR1, PPARG, HMGA2, and MTHFR Genes Are Associated With Polycystic Ovary Syndrome Risk in a Chinese Population: A Case-Control Study.
[Association of methylenetetrahydrofolate reductase gene polymorphisms with polycystic ovary syndrome].
Polycythemia
Venous thromboembolism associated with hyperhomocysteinemia, homozygosity for the methylenetetrahydrofolate reductase 677C>T gene variant, and secondary polycythemia.
Polycythemia Vera
The relationship between factor V Leiden, prothrombin G20210A, and MTHFR mutations and the first major thrombotic episode in polycythemia vera and essential thrombocythemia.
Polyneuropathies
5,10-Methylenetetrahydrofolate reductase deficiency with progressive polyneuropathy in an infant.
Porphyrias
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Pre-Eclampsia
5,10 methylenetetrahydrofolate reductase polymorphism in black South African women with pre-eclampsia.
677 C-->T polymorphism of the methylenetetrahydrofolate reductase gene and preeclampsia.
Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and preeclampsia in Japanese women.
Analysis of polymorphisms and haplotypes in genes associated with vascular tone, hypertension and oxidative stress in Mexican-Mestizo women with severe preeclampsia.
Association between plasminogen activator inhibitor 1 gene polymorphisms and preeclampsia.
Association between the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to preeclampsia: the need for data clarification in a recent meta-analysis.
Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene with hypertension in pregnancy and pre-eclampsia: a meta-analysis.
Association of gene polymorphisms of FV, FII, MTHFR, SERPINE1, CTLA4, IL10, and TNFalpha with pre-eclampsia in Chinese women.
Association of methylenetetrahydrofolate reductase C677T and reduced-f carrier-1 G80A gene polymorphism with preeclampsia in Sudanese women.
Association of methylenetetrahydrofolate reductase C677T polymorphism with the pre-eclampsia risk in Hakka pregnant women in Southern China.
Association of MTHFR A1298C polymorphism (but not of MTHFR C677T) with elevated homocysteine levels and placental vasculopathies.
Association of MTHFR C677T Polymorphism with Preeclampsia in North East of Iran (Khorasan Province).
Association of pre-eclampsia with hyperhomocysteinaemia and methylenetetrahydrofolate reductase gene C677T polymorphism in a Turkish population.
Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women.
Carriage of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism does not influence the first and second trimester uterine artery Doppler flow.
Congenital thrombophilia associated to obstetric complications.
Correlation between MTHFR gene methylation and pre-eclampsia, and its clinical significance.
Differential global and MTHFR gene specific methylation patterns in preeclampsia and recurrent miscarriages: A case-control study from North India.
Epigenetic Modification in Methylene Tetrahydrofolate Reductase (MTHFR) Gene of Women with Pre-eclampsia.
Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.
Ethnic differences in the association of factor V Leiden mutation and the C677T methylenetetrahydrofolate reductase gene polymorphism with preeclampsia.
Evaluation of methylenetetrahydrofolate reductase (MTHFR) activity and the levels of homocysteine and malondialdehyde (MDA) in the serum of women with preeclampsia.
Factor V Leiden and thermolabile methylenetetrahydrofolate reductase gene variants in an East Anglian preeclampsia cohort.
Factor V Leiden, C > T MTHFR polymorphism and genetic susceptibility to preeclampsia.
Factor V Leiden, Prothrombin and MTHFR Mutation in Patients with Preeclamsia, Intrauterine Growth Restriction and Placental Abruption.
Fetal genotype for specific inherited thrombophilias is not associated with severe preeclampsia.
Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia.
Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis.
Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review.
Frequency of factor V, prothrombin and methylenetetrahydrofolate reductase gene variants in preeclampsia.
Gene-environment interactions: a review of effects on reproduction and development.
Genetic susceptibility to preeclampsia: roles of cytosineto-thymine substitution at nucleotide 677 of the gene for methylenetetrahydrofolate reductase, 68-base pair insertion at nucleotide 844 of the gene for cystathionine beta-synthase, and factor V Leiden mutation.
Genetic thrombophilias and preeclampsia: a meta-analysis.
Genetic thrombophilias and uterine artery Doppler velocimetry and preeclampsia.
Genetic variants in 3'-UTRs of MTHFR in the pregnancies complicated with preeclampsia and bioinformatics analysis.
Hyperhomocysteinaemia: a risk factor for preeclampsia?
Hyperhomocysteinemia is not sufficient to cause preeclampsia in an animal model: the importance of folate intake.
Maternal and fetal variants of genetic thrombophilias and the risk of preeclampsia.
Maternal and neonatal outcome of preeclamptic pregnancies: the potential roles of factor V Leiden mutation and 5,10 methylenetetrahydrofolate reductase.
Maternal factor V Leiden mutation is associated with HELLP syndrome in Caucasian women.
Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to pre-eclampsia.
Methylene tetrahydrofolate reductase and methionine synthase gene polymorphisms as genetic determinants of pre-eclampsia.
Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T Polymorphism and Risk of Preeclampsia: An Updated Meta-analysis Based on 51 Studies.
Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe.
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women.
Methylenetetrahydrofolate reductase C677T and glutathione S-transferase P1 A313G are associated with a reduced risk of preeclampsia in Maya-Mestizo women.
Methylenetetrahydrofolate reductase C677T polymorphism and pregnancy complications.
Methylenetetrahydrofolate Reductase Enzyme Level and Antioxidant Activity in Women with Gestational Hypertension and Pre-eclampsia in Lagos, Nigeria.
Methylenetetrahydrofolate reductase gene C677T, A1298C polymorphisms and pre-eclampsia risk: a meta-analysis.
Methylenetetrahydrofolate reductase gene polymorphisms in black South Africans and the association with preeclampsia.
Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia.
Methylenetetrahydrofolate reductase polymorphism, folate, and susceptibility to preeclampsia.
Methylenetetrahydrofolate reductase polymorphisms in preeclampsia and the HELLP syndrome.
MTHFR and F5 genetic variations have association with preeclampsia in Pakistani patients: a case control study.
MTHFR C677T and eNOS G894T variants in preeclamptic women: Contribution to lipid peroxidation and oxidative stress.
MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in Finnish women.
Mutations in the gene for methylenetetrahydrofolate reductase, homocysteine levels, and vitamin status in women with a history of preeclampsia.
Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in nulliparous women complicated with preeclampsia.
Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in the placenta of pregnancies complicated with preeclampsia.
Preeclampsia and its interaction with common variants in thrombophilia genes.
Preeclampsia in North Indian women: the contribution of genetic polymorphisms.
Relationship between polymorphisms in thrombophilic genes and preeclampsia in a Brazilian population.
The 677 C-T methylenetetrahydrofolate reductase mutation does not predict increased maternal homocysteine during pregnancy.
The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia.
The association between maternal methylenetetrahydrofolate reductase C677T and A1298C polymorphism and birth defects and adverse pregnancy outcomes.
The association between methylenetetrahydrofolate reductase C677T polymorphism and pre-eclampsia risk: appraisal of a recent meta-analysis.
The association of the Placental MTHFR 3'-UTR polymorphisms, promoter methylation and MTHFR expression with Preeclampsia.
The early-onset preeclampsia is associated with MTHFR and FVL polymorphisms.
The importance of MTHFR, MTR, MTRR and CSE expression levels in Caucasian women with preeclampsia.
The methylenetetrahydrofolate reductase 677 C-->T polymorphism and preeclampsia in two populations.
Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study.
[Carriers of thrombophilic factor among women with preeclampsia (preliminary report)]
[Folate-related processes in human placenta: gene expression, aminothiols, proliferation and apoptosis].
[Folic acid levels, homocysteine and polymorphism of methylenetetrahydrofolate reductase enzyme (MTHFR) in patients with pre-eclampsia and eclampsia]
[Genetic trombophilia and markers of endotelial activation in patients with preeclampsia]
[Occurrence of gene mutations in factor V Leiden, prothrombin and methylenetetrahydrofolate reductase in patients with pre-eclampsia]
[Screening for pre-eclampsia in a low-risk population at 24 weeks: uterine artery Doppler flow velocimetry and genetic variants of factor V, prothrombin and methylenetetrahydrofolate reductase]
[The common C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with neural tube defects and preeclampsia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis.
A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia.
A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children.
A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia.
Additional genetic risk factor for death in children with acute lymphoblastic leukemia: a common polymorphism of the MTHFR gene.
Assessment of the relationship between methylenetetrahydrofolate reductase polymorphism and acute lymphoblastic leukemia: Evidence from an updated meta-analysis.
Association between Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphisms and Susceptibility to Childhood Acute Lymphoblastic Leukemia in an Iranian Population.
Association between methylenetetrahydrofolate reductase polymorphisms and the relapse of acute lymphoblastic leukemia: a meta-analysis.
Association between MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Meta-Analysis Based on 51 Case-Control Studies.
Association between MTHFR microRNA binding site polymorphisms and methotrexate concentrations in Chinese pediatric patients with acute lymphoblastic leukemia.
Association between plasma homocysteine and riboflavin status in Acute Lymphoblastic Leukemia in children.
Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in serbian children.
Association of methylenetetrahydrofolate reductase gene-gene interaction and haplotype with susceptibility to acute lymphoblastic leukemia in Chinese children.
Association of the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) polymorphisms in Korean patients with adult acute lymphoblastic leukemia.
Association of the methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia.
Cerebral venous sinus thrombosis in children with acute lymphoblastic leukemia carrying the MTHFR TT677 genotype and further prothrombotic risk factors.
Chapter 13 methylenetetrahydrofolate reductase, common polymorphisms, and relation to disease.
Combined 677CC/1298AC genotypes of methylenetetrahydrofolate reductase (MTHFR ) reduce susceptibility to precursor B lymphoblastic leukemia in a Chinese population.
Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults.
Comparative pharmacogenetic analysis of risk polymorphisms in Caucasian and Vietnamese children with acute lymphoblastic leukemia: prediction of therapeutic outcome?
Comprehensive analysis of Methylenetetrahydrofolate reductase C677T in younger acute lymphoblastic leukemia patients: A single-center experience.
Do polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene affect the risk of childhood acute lymphoblastic leukemia?
Effect of folate status and methylenetetrahydrofolate reductase genotypes on the complications and outcome of high dose methotrexate chemotherapy in north Indian children with acute lymphoblastic leukemia.
Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia or lymphoma.
Effects of methylenetetrahydrofolate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population.
Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors.
Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia.
Functional variants of gene encoding folate metabolizing enzyme and methotrexate-related toxicity in children with acute lymphoblastic leukemia.
Genetic variation in the folate metabolic pathway and risk of childhood leukemia.
Genotyping of the MTHFR gene polymorphism, C677T in patients with leukemia by melting curve analysis.
Genotyping of two single nucleotide polymorphisms in 5,10-methylenetetrahydrofolate reductase by multiplex polymerase chain reaction and capillary electrophoresis.
Germline variation in the MTHFR and MTRR genes determines the nadir of bone density in pediatric acute lymphoblastic leukemia: A prospective study.
Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene, predisposes to 6-MP related toxicities in childhood ALL patients.
High dose methotrexate treatment in childhood ALL: pilot study on the impact of the MTHFR 677C>T and 1298A>C polymorphisms on MTX-related toxicity.
Impact of methylenetetrahydrofolate reductase (MTHFR) polymorphisms on methotrexate-induced toxicities in acute lymphoblastic leukemia: a meta-analysis.
Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia.
Influence of genetic polymorphisms on the risk of developing leukemia and on disease progression.
Influence of Methylenetetrahydrofolate Reductase C677T, A1298C, and G80A Polymorphisms on the Survival of Pediatric Patients with Acute Lymphoblastic Leukemia.
Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma.
Influence of plasma methotrexate level and MTHFR genotype in Korean paediatric patients with acute lymphoblastic leukaemia.
Influence of variants in folate metabolism genes on 6-mercaptopurine induced toxicity during treatment for childhood acute lymphocytic leukemia.
Involvement of C677T MTHFR variant but not A1298C in methotrexate-induced toxicity in acute lymphoblastic leukemia.
Involvement of MTHFR and TPMT genes in susceptibility to childhood acute lymphoblastic leukemia (ALL) in Mexicans.
Involvement of MTHFR rs1801133 in the Susceptibility of Acute Lymphoblastic Leukemia: A Preliminary Study.
Lack of Association Between MTHFR C677T and A1298C Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia in the Kurdish Population from Western Iran.
Lack of association between polymorphisms in genes MTHFR and MDR1 with risk of childhood acute lymphoblastic leukemia.
Maternal Haplotypes in DHFR Promoter and MTHFR Gene in Tuning Childhood Acute Lymphoblastic Leukemia Onset-Latency: Genetic/Epigenetic Mother/Child Dyad Study (GEMCDS).
Meta-analyzing the link between MTHFR C677T genotype and susceptibility to childhood ALL.
Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations.
Methotrexate consolidation treatment according to pharmacogenetics of MTHFR ameliorates event-free survival in childhood acute lymphoblastic leukaemia.
Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia.
Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma.
Methylenetetrahydrofolate reductase C677T and A1298C polymorphism and susceptibility to acute lymphoblastic leukemia in a cohort of Egyptian children.
Methylenetetrahydrofolate reductase C677T and overall survival in pediatric acute lymphoblastic leukemia: a systematic review.
Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro.
Methylenetetrahydrofolate reductase C677T polymorphism: association with risk for childhood acute lymphoblastic leukemia and response during the initial phase of chemotherapy in greek patients.
Methylenetetrahydrofolate reductase gene haplotypes affect toxicity during maintenance therapy for childhood acute lymphoblastic leukemia in Japanese patients.
Methylenetetrahydrofolate reductase gene polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis based on 28case-control studies.
Methylenetetrahydrofolate reductase gene polymorphisms and risk of acute lymphoblastic leukemia in children.
Methylenetetrahydrofolate reductase gene polymorphisms: association with risk for pediatric acute lymphoblastic leukemia in north Indians.
Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population.
Methylenetetrahydrofolate reductase polymorphism C677T is a protective factor for pediatric acute lymphoblastic leukemia in the Chinese population: a meta-analysis.
Methylenetetrahydrofolate reductase polymorphisms and susceptibility to acute lymphoblastic leukemia in a Chinese population: a meta-analysis.
Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemia.
Methylenetetrahydrofolate reductase polymorphisms, serum methylenetetrahydrofolate reductase levels, and risk of childhood acute lymphoblastic leukemia in a Chinese population.
Mexican Childhood Acute Lymphoblastic Leukemia: A Pilot Study of the MDR1 and MTHFR Gene Polymorphisms and Their Associations with Clinical Outcomes.
MTHFR 677 (C-->T) polymorphism is not relevant for prognosis or therapy-associated toxicity in pediatric NHL: results from 484 patients of multicenter trial NHL-BFM 95.
MTHFR 677 C>T genotype and adverse outcomes in treatment of childhood ALL: is the jury in?
MTHFR 677CC/1298CC genotypes are highly associated with chronic myelogenous leukemia: a case-control study in Korea.
MTHFR 677T-1298C haplotype in acute lymphoblastic leukemia: Impact on methotrexate therapy.
MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: A meta-analysis.
MTHFR gene polymorphism in acute lymphoblastic leukemia among North Indian children: a case-control study and meta-analysis updated from 2011.
MTHFR Gene Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Adults and Children: A Case Control Study in India.
MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia.
MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy.
MTHFR polymorphisms' influence on outcome and toxicity in acute lymphoblastic leukemia patients.
MTHFR single nucleotide polymorphism associated with working memory in pediatric medulloblastoma survivors.
MTHFR-C677T Gene Polymorphism and Susceptibility to Acute Lymphoblastic Leukemia in Children: A Meta-Analysis.
No evidence of association of methylenetetrahydrofolate reductase polymorphism with occurrence of second neoplasms after treatment of childhood leukemia.
Pharmacogenetic studies in children with acute lymphoblastic leukemia in Argentina.
Pharmacogenetic Variants in MTHFR Gene are Significant Predictors of Methotrexate Toxicities in Bangladeshi Patients With Acute Lymphoblastic Leukemia.
Polymorphisms in methylenetetrahydrofolate reductase and methotrexate sensitivity in childhood acute lymphoblastic leukemia.
Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults.
Polymorphisms in the MTHFR gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in an Indian population.
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase, dietary folate intake, and the risk of leukemia in adults.
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population.
Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in North India.
Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate.
Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors.
Reduced folate carrier and methylenetetrahydrofolate reductase gene polymorphisms: associations with clinical outcome in childhood acute lymphoblastic leukemia.
Role of folate status and methylenetetrahydrofolate reductase genotype on the toxicity and outcome of induction chemotherapy in children with acute lymphoblastic leukemia.
Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.
Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia.
Rs4846049 Polymorphism at the 3'-UTR of MTHFR Gene: Association with Susceptibility to Childhood Acute Lymphoblastic Leukemia.
Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury.
Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia.
The association between methylenetetrahydrofolate reductase C677 > T polymorphisms and risk of pediatric acute lymphoblastic leukemia in Asia.
The association of methylenetetrahydrofolate reductase genotypes with the risk of childhood leukemia in Taiwan.
The Effect of RFC G80A Polymorphism in Cretan children with acute lymphoblastic leukemia and its interaction with MTHFR C677T and A1298C polymorphisms.
The Influence of Genetic RFC1, MS and MTHFR Polymorphisms on the Risk of Acute Lymphoblastic Leukemia Relapse in Children and the Adverse Effects of Methotrexate.
The methylenetetrahydrofolate reductase 677T-1298C haplotype is a risk factor for acute lymphoblastic leukemia in children.
The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia.
The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal.
The MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: an updated meta-analysis based on 37 case-control studies.
The MTHFR polymorphism C677T in adult patients with acute lymphoblastic leukemia is associated with an increased prevalence of cytogenetic abnormalities.
The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia.
The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population.
The role of the methylenetetrahydrofolate reductase 677 and 1298 polymorphisms in Cretan children with acute lymphoblastic leukemia.
Thrombosis in children with hematologic malignancies.
TPMT and MTHFR genotype is not associated with altered risk of thioguanine-related sinusoidal obstruction syndrome in pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group.
TS Gene Polymorphisms Correlate with Susceptibility to Acute Lymphocytic Leukemia in Children.
Use of MTHFR C677T polymorphism and plasma pharmacokinetics to predict methotrexate toxicity in patients with acute lymphoblastic leukemia.
Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: A synthesis of genetic association studies.
[A case of acute lymphoblastic leukemia of MTHFR C677T gene positive with methotrexate hypersensitivity was successfully rescued by hemodialysis].
[A new method for 5, 10-methylenetetrahydrofolate reductase single nucleotide polymorphisms genotyping used to study susceptibility of hematological malignancy]
[Association between mthfr gene polymorphisms and toxicity of HDMTX chemotherapy in acute lymphocytic leukemia]
[Association between the methylenetetrahydrofolate reductase gene polymorphisms and haplotype with toxicity response of high dose methotrexate chemotherapy].
[Association of single nucleotide polymorphism of methylenetetrahydrofolate reductase gene with susceptibility to acute leukemia].
[PROVISIONAL] The differential effects of the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) on hematological malignancies among Latinos: a meta-analysis.
[Relationship between the methylenetetrahydrofolate reductase gene polymorphism and adverse reactions of high-dose methotrexate in children with acute lymphocytic leukemia].
Pregnancy Complications
Association of MTHFR A1298C polymorphism (but not of MTHFR C677T) with elevated homocysteine levels and placental vasculopathies.
Association of Plasminogen Activator Inhibitor-1 Gene Polymorphisms and Methylene Tetrahydrofolate Reductase Polymorphisms with Spontaneous Miscarriages.
Associations between maternal methylenetetrahydrofolate reductase polymorphisms and adverse outcomes of pregnancy: the Hordaland Homocysteine Study.
Characterization of a pseudogene for murine methylenetetrahydrofolate reductase.
Detection of human genome mutations associated with pregnancy complications using 3-D microarray based on macroporous polymer monoliths.
Ethnic differences in the association of thrombophilic polymorphisms with obstetric complications in slovak and roma (gypsy) populations.
Evaluation of Factor V Leiden, Prothrombin and Methylenetetrahydrofolate Reductase Gene Mutations in Patients with Severe Pregnancy Complications in Northern Finland.
Factor V Leiden, pregnancy complications and adverse outcomes: the Hordaland Homocysteine Study.
Genetic thromobophilia in pregnancy: a case-control study among North Indian women.
Individualized Supplementation of Folic Acid According to Polymorphisms of Methylenetetrahydrofolate Reductase (MTHFR), Methionine Synthase Reductase (MTRR) Reduced Pregnant Complications.
Inherited thrombophilia and anticoagulant therapy for women with reproductive failure.
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-? in spleen and placenta, and through reduction of methylation potential.
Methylenetetrahydrofolate reductase C677T polymorphism and pregnancy complications.
Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice.
Methylenetetrahydrofolate reductase gene A1298C polymorphism and susceptibility to recurrent pregnancy loss: a meta-analysis.
MTHFR Gene variants C677T, A1298C and association with Down syndrome: A Case-control study from South India.
Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms.
Physiologic changes in homocysteine metabolism in pregnancy: A longitudinal study in Spain.
Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences.
Prevalence of the methylenetetrahydrofolate reductase 677C>T polymorphism in the pregnant women of Yunnan Province, China.
Pronto ThromboRisk--a novel primer-extension ELISA based assay for the detection of mutations associated with increased risk for thrombophilia.
The association between maternal methylenetetrahydrofolate reductase C677T and A1298C polymorphism and birth defects and adverse pregnancy outcomes.
The C677T methylenetetrahydrofolate reductase variant and third trimester obstetrical complications in women with unexplained elevations of maternal serum alpha-fetoprotein.
[Genetic mutations, acquired coagulation system disorders and obstetric pathology. Personal experience]
[Thrombophilia, preeclampsia and other pregnancy complications]
Pregnancy, High-Risk
The role of maternal homocysteine concentration in placenta-mediated complications: findings from the Ottawa and Kingston birth cohort.
Pregnancy, Tubal
Common Methylenetetrahydrofolate Reductase Polymorphisms (A1298C & C677T) in Ectopic Trophoblasts and Methotrexate Treatment Failure in Tubal Pregnancies.
Contribution of genetic polymorphism of methylene tetrahydrofolate reductase on the effect of methotrexate in ectopic pregnancy patients.
Premature Birth
Genetic polymorphism of MTHFR C677T with preterm birth and low birth weight susceptibility: a meta-analysis.
Genetic variations of MTHFR gene and their association with preterm birth in Korean women.
Methylenetetrahydrofolate reductase polymorphisms at 3'-untranslated region are associated with susceptibility to preterm birth.
Thrombophilic polymorphisms--factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations--and preterm birth.
Presbycusis
Polymorphisms in folate metabolism genes are associated with susceptibility to presbycusis.
Primary Ovarian Insufficiency
Association between premature ovarian failure, polymorphisms in MTHFR and MTRR genes and serum homocysteine concentration.
Association of methylenetetrahydrofolate reductase (MTHFR 677C>T) and thymidylate synthase (TSER and TS 1494del6) polymorphisms with premature ovarian failure in Korean women.
[Correlation Between MTHFR Mutation and Idiopathic Premature Ovarian Failure in Chinese Han Women].
Proctitis
Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis, in Central China.
Prostatic Diseases
MTHFR polymorphism and the risk of prostate cancer: a meta-analysis of case-control studies.
Prostatic Hyperplasia
Polymorphisms in the methylenetetrahydrofolate reductase gene and prostate cancer risk.
Prostatic Neoplasms
Analysis of relation between C677T genotype in MTHFR gene and prostatic cancer in Iranian males.
Association between MTHFR C677T Polymorphism and Risk of Prostate Cancer: Evidence from 22 Studies with 10,832 Cases and 11,993 Controls.
Association between MTHFR gene polymorphisms (C677T, A1298C) and genetic susceptibility to prostate cancer: a meta-analysis.
Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans.
Complex interaction between serum folate levels and genetic polymorphisms in folate pathway genes: biomarkers of prostate cancer aggressiveness.
Effects of the MTHFR C677T Polymorphism on Prostate Specific Antigen and Prostate Cancer.
Folate intake, alcohol consumption, and the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism: influence on prostate cancer risk and interactions.
Genetic Polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) Genes Associated With Pathological Characteristics of Prostate Cancer in the Ecuadorian Population.
Genetic variants in metabolizing genes NQO1, NQO2, MTHFR and risk of prostate cancer: a study from North India.
MTHFR c.677C>T Inhibits Cell Proliferation and Decreases Prostate Cancer Susceptibility in the Han Chinese Population in Shanghai.
MTHFR C677T polymorphism contributes to prostate cancer risk among Caucasians: A meta-analysis of 3511 cases and 2762 controls.
MTHFR polymorphism and the risk of prostate cancer: a meta-analysis of case-control studies.
No association of the MTHFR gene A1298C polymorphism with the risk of prostate cancer: A meta-analysis.
Polymorphisms in the methylenetetrahydrofolate reductase gene and prostate cancer risk.
Polymorphisms of methylenetetrahydrofolate reductase and the risk of prostate cancer: a nested case-control study.
Prognostic Relevance of Methylenetetrahydrofolate Reductase Polymorphisms for Prostate Cancer.
Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes and prostate cancer risk and aggressiveness.
Relationship between three polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T, A1298C, and G1793A) gene and risk of prostate cancer: a case-control study.
Risk of prostate cancer and thrombosis-related factor polymorphisms.
Serum folate and vitamin B12 concentrations in relation to prostate cancer risk--a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohort.
Significant association of methylenetetrahydrofolate reductase single nucleotide polymorphisms with prostate cancer susceptibility in taiwan.
The analysis of the relationship between A1298C and C677T polymorphisms of the MTHFR gene with prostate cancer in Eskisehir population.
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: the Croatian case-control study.
The MTHFR 677C-->T polymorphism and risk of prostate cancer: results from the CAPS study.
The MTHFR C677T Polymorphism and Prostate Cancer Risk: New Findings from a Meta-analysis of 7306 Cases and 8062 Controls.
The protective effect of methylenetetrahydrofolate reductase C677T polymorphism against prostate cancer risk: Evidence from 23 case-control studies.
Protein C Deficiency
A study of hyperhomocysteinemia in cerebral venous sinus thrombosis.
Does thrombophilia play an aetiological role in Legg-Calvé-Perthes disease?
Etiology of hypercoagulable state in women with recurrent fetal loss without other causes of miscarriage from Southern Italy: new clinical target for antithrombotic therapy.
Evaluation of cerebral venous thrombosis secondary to oral contraceptive use in adolescents.
How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review.
Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies.
Ischemic stroke subtypes and thrombophilia in young and elderly Brazilian stroke patients admitted to a rehabilitation hospital.
Lipoprotein (a) and genetic polymorphisms of clotting factor V, prothrombin, and methylenetetrahydrofolate reductase are risk factors of spontaneous ischemic stroke in childhood.
Livedoid vasculopathy and hypercoagulability in a patient with primary Sjögren's syndrome.
Myocardial infarction and venous thrombosis in a 42-year old woman with heterozygous methylenetetrahydrofolate reductase (MTHRF) gene mutation, hyperhomocysteinemia, and protein C deficiency.
Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors.
Recurrent miscarriage syndrome and infertility due to blood coagulation protein/platelet defects: a review and update.
Review of Management and Outcomes in Women with Thrombophilia Risk during Pregnancy at a Single Institution.
Severe purpura fulminans due to coexistence of homozygous protein C deficiency and homozygous methylenetetrahydrofolate reductase mutation.
The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus.
Thrombophilia and first arterial ischaemic stroke: a systematic review.
Thrombophilic risk factors in hemodialysis: Association with early vascular access occlusion and patient survival in long-term follow-up.
Treatment of adverse perinatal outcome in inherited thrombophilias: a clinical study.
[Cerebral venous thrombosis: when etiology makes the difference.]
Protein Deficiency
Lack of Association between Recurrent Pregnancy Loss and Inherited Thrombophilia in a Group of Colombian Patients.
Primary thrombophilia in Mexico: a single tertiary referral hospital experience.
Protein S Deficiency
A study of hyperhomocysteinemia in cerebral venous sinus thrombosis.
Association of hereditary thrombophilia with intrauterine growth restriction.
Etiology of hypercoagulable state in women with recurrent fetal loss without other causes of miscarriage from Southern Italy: new clinical target for antithrombotic therapy.
FV Leiden mutation and risk of recurrent venous thromboembolism in Serbian population.
How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review.
Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies.
Implantation of left ventricular assist device complicated by undiagnosed thrombophilia.
Inherited thrombophilia and anticoagulant therapy for women with reproductive failure.
Ischemic stroke subtypes and thrombophilia in young and elderly Brazilian stroke patients admitted to a rehabilitation hospital.
Outcome of kidney transplantation in patients with inherited thrombophilia: data of a prospective study.
Recurrent miscarriage syndrome and infertility due to blood coagulation protein/platelet defects: a review and update.
Review article: the aetiology of primary Budd-Chiari syndrome - differences between the West and China.
Review of Management and Outcomes in Women with Thrombophilia Risk during Pregnancy at a Single Institution.
Risk factors associated with postpartum ovarian vein thrombosis.
Sequential multiple retinal vein occlusions and transient ischemic attack in MTHFR polymorphism and protein S deficiency.
The relationship between pregnancy induced hypertension and congenital thrombophilia.
The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus.
Thrombophilia and first arterial ischaemic stroke: a systematic review.
Thrombophilic risk factors in hemodialysis: Association with early vascular access occlusion and patient survival in long-term follow-up.
Treatment of adverse perinatal outcome in inherited thrombophilias: a clinical study.
Use of hyperbaric oxygen therapy of purpura fulminans in an extremely low birth weight preterm: A case report.
Venous Thromboembolism at Uncommon Sites in Neonates and Children.
Venous thromboembolism in young patients from western India: a study.
Warfarin skin necrosis associated with protein S deficiency and a mutation in the methylenetetrahydrofolate reductase gene.
Proteinuria
Association of methylenetetrahydrofolate reductase T677 allele with early development of chronic allograft nephropathy.
Effect of nephrotic syndrome on homocysteine metabolism.
Fingertips ischemia, nephroangiosclerosis, and focal segmental glomerulosclerosis: is genetic thrombophilia the unique explanation?
Pseudarthrosis
[Methylenetetrahydrofolate reductase polymorphism C677T in patients with consolidated fractures and pseudarthrosis of long bones: relationship with homocystein and inflammatory mediators].
Pseudoxanthoma Elasticum
Can APOE and MTHFR polymorphisms have an influence on the severity of cardiovascular manifestations in Italian Pseudoxanthoma elasticum affected patients?
Clinical and Genetic Heterogeneity in a Large Family with Pseudoxanthoma Elasticum: MTHFR and SERPINE1 Variants as Possible Disease Modifiers in Developing Ischemic Stroke.
Psoriasis
Association between methylenetetrahydrofolate reductase C677T polymorphism and psoriasis: A meta-analysis.
Association between MTHFR 677C/T polymorphism and psoriasis risk: a meta-analysis.
Goeckerman Therapy of Psoriasis: Genotoxicity, Dietary Micronutrients, Homocysteine, and MTHFR Gene Polymorphisms.
Homocysteine: A Potential Common Route for Cardiovascular Risk and DNA Methylation in Psoriasis.
Interaction of MTHFR gene with smoking and alcohol use and haplotype combination susceptibility to psoriasis in Chinese population.
Methylenetetrahydrofolate reductase (MTHFR) 677C>T gene polymorphism as a possible factor for reducing clinical severity of psoriasis.
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey.
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases.
Methylenetetrahydrofolate Reductase C677T Gene Polymorphism as Risk Factor for Psoriasis in Saudis.
MTHFR (methylenetetrahydrofolate reductase) C677T polymorphism and psoriasis.
Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms.
Possible association between germline methylenetetrahydrofolate reductase gene polymorphisms and psoriasis risk in a Turkish population.
Study of the relationship between psoriasis and the polymorphic site C677T of methylenetetrahydrofolate reductase.
The methylenetetrahydrofolate reductase 677C>T gene polymorphism is not associated with chronic plaque psoriasis.
Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.
Pulmonary Embolism
Aortic Thrombus and Acute Pulmonary Embolism in an Individual Heterozygous for the MTHFR C677-T Mutation.
Aortic thrombus and acute pulmonary embolism in an individual heterozygous for the MTHFR C677T mutation.
Association of folate metabolism gene polymorphisms and haplotype combination with pulmonary embolism risk in Chinese Han population.
Association of folate metabolism gene polymorphisms and pulmonary embolism: A case-control study of West-Siberian population.
Contraception-related deep venous thrombosis and pulmonary embolism in a 17-Year-old girl heterozygous for factor V leiden, prothrombin G20210A mutation, MTHFR C677T and homozygous for PAI-1 mutation: report of a family with multiple genetic risk factors and review of the literature.
Correlations between methylenetetrahydrofolate reductase gene polymorphisms and venous thromboembolism: A meta-analysis of 99 genetic association studies.
Factor V gene G1691A mutation, prothrombin gene G20210A mutation, and MTHFR gene C677T mutation are not risk factors for pulmonary thromboembolism in Chinese population.
Frequency of thrombophilia-related genetic variations in patients with idiopathic pulmonary embolism in an urban emergency department.
Hereditary thrombophilia in ethnic omani patients.
Massive Pulmonary Embolism Associated With Factor V Leiden, Prothrombin, and Methylenetetrahydrofolate Reductase Gene Mutations in a Young Patient on Oral Contraceptive Pills: A Case Report.
Massive pulmonary embolism in a Lebanese patient doubly heterozygous for MTHFR and Factor V Leiden presenting with syncope and treated with tenecteplase.
Molecular Analysis of Prothrombotic Gene Variants in Venous Thrombosis: A Potential Role for Sex and Thrombotic Localization.
Polymorphisms C677T and A1298C of MTHFR Gene: Homocysteine Levels and Prothrombotic Biomarkers in Coronary and Pulmonary Thromboembolic Disease.
Pulmonary embolism and premature labor in a patient with both factor V Leiden mutation and methylenetetrahydrofolate reductase gene C677T mutation.
Pulmonary Embolism in a Sarcoidosis Patient Double Heterozygous for Methylenetetrahydrofolate Reductase Gene Polymorphisms and Factor V Leiden and Homozygous for the D-Allele of Angiotensin Converting Enzyme Gene.
Pulmonary Thromboembolism Following Radio-Frequency Ablation of the Atrioventricular Node in a Patient Heterozygous for the Factor V Leiden and the Mthfr C677T Mutations.
Rare variants in MTHFR predispose to occurrence and recurrence of pulmonary embolism.
Severe methylenetetrahydrofolate reductase deficiency revealed by a pulmonary embolism in a young adult.
ST-elevation myocardial infarction, pulmonary embolism, and cerebral ischemic stroke in a patient with critically low levels of natural anticoagulants.
The importance of MTHFR C677T/A1298C combined polymorphisms in pulmonary embolism in Turkish population.
Thrombophilia-related genetic variations in patients with pulmonary embolism in the main teaching hospital in Jordan.
Purpura
METHYLENETETRAHYDROFOLATE REDUCTASE C677T POLYMORPHISM IN PATIENTS WITH HENOCH-SCHÖNLEIN PURPURA.
Purpura Fulminans
Purpura Fulminans as the presenting manifestation in a patient with homozygous methylenetetrahydrofolate reductase gene mutation.
Severe purpura fulminans due to coexistence of homozygous protein C deficiency and homozygous methylenetetrahydrofolate reductase mutation.
Pyoderma
Pyoderma gangrenosum-like lesion secondary to methylenetetrahydrofolate reductase mutation: an unusual presentation of a rare disease.
Pyoderma Gangrenosum
Hydroxyurea-Induced Leg Ulceration in a Patient With a Homozygous MTHFR Polymorphism Misdiagnosed as Pyoderma Gangrenosum.
Pyoderma gangrenosum-like lesion secondary to methylenetetrahydrofolate reductase mutation: an unusual presentation of a rare disease.
Skin ulcers mimicking pyoderma gangrenosum in a patient with MTHFR polymorphism.
The use of B vitamins for cutaneous ulcerations mimicking pyoderma gangrenosum in patients with MTHFR polymorphism.
Pyruvate Dehydrogenase Complex Deficiency Disease
Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.
pyruvate kinase deficiency
Moya moya syndrome in a child with pyruvate kinase deficiency and combined prothrombotic factors.
Quadriplegia
Associations between inherited thrombophilias, gestational age, and cerebral palsy.
Radiation Pneumonitis
A single-nucleotide polymorphism in the MTHFR (methylene tetrahydrofolate reductase) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy.
Genetic Variants in MTHFR Gene Predict ? 2 Radiation Pneumonitis in Esophageal Squamous Cell Carcinoma Patients Treated with Thoracic Radiotherapy.
Rectal Neoplasms
A common variant in MTHFR influences response to chemoradiotherapy and recurrence of rectal cancer.
A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation.
Associations between 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 genetic polymorphisms and environmental factors with reference to susceptibility to colorectal cancer: a case-control study in an Indian population.
Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations.
Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer.
Diets, polymorphisms of methylenetetrahydrofolate reductase, and the susceptibility of colon cancer and rectal cancer.
Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma.
Genetic polymorphisms of methylenetetrahydrofolate reductase and susceptibility to colorectal cancer.
Germline and somatic genetic predictors of pathological response in neoadjuvant settings of rectal and esophageal cancers: systematic review and meta-analysis.
Glutathione S-transferase P1 Ile105Val polymorphism is associated with haematological toxicity in elderly rectal cancer patients receiving preoperative chemoradiotherapy.
Immunohistochemical and genetic prognostic factors of neoadjuvant chemoradiotherapy effic?cy in personalized treatment of local advanced rectal cancer.
Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer.
Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea.
MTHFR, TSER and DPYD gene mutation is associated with toxicity and response in pre-operative chemo-radiotherapy for local advanced rectal cancer.
Nutrients in Folate-Mediated, One-Carbon Metabolism and the Risk of Rectal Tumors in Men and Women.
Polymorphisms of MTHFR C677T and A1298C associated with survival in patients with colorectal cancer treated with 5-fluorouracil-based chemotherapy.
Risk factors for rectal cancer and methylenetetrahydrofolate reductase polymorphisms in a population in Northeast Thailand.
SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer.
Renal Artery Obstruction
Genetic variants in hypertensive patients with coronary artery disease and coexisting atheromatous renal artery stenosis.
Homocysteine and atheromatous renal artery stenosis.
Renal Insufficiency
Genetic determinants of the homocysteine level.
Genetic Predisposition for Development of Nephropathy in Type 2 Diabetes Mellitus.
Homocysteine, endothelial dysfunction, and coronary artery disease: emerging strategy for secondary prevention.
Homocysteine, folate, vitamin B12 levels, and C677T MTHFR mutation in children with renal failure.
Homocysteine, methylenetetrahydrofolate reductase polymorphism, antiphospholipid antibodies, and thromboembolic events in systemic lupus erythematosus: a retrospective cohort study.
Hyperhomocysteinemia and polymorphisms of the methylenetetrahydrofolate gene in hemodialysis and peritoneal dialysis patients.
Methylenetetrahydrofolate Reductase gene polymorphism in patients receiving hemodialysis.
Methylenetetrahydrofolate reductase gene polymorphisms in essential hypertension relation: with the development of hypertensive end-stage renal disease.
Methylenetetrahydrofolate-reductase gene C677T variant and kidney-transplant survival.
Relationship of MTHFR gene polymorphisms with renal and cardiac disease.
Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism.
Renal Insufficiency in Non-Diabetic Subjects: Relationship of MTHFR C677t Gene Polymorphism and Left Ventricular Hypertrophy.
Severe atherosclerosis in rheumatoid arthritis and hyperhomocysteinemia: is there a link?
The association between end-stage diabetic nephropathy and methylenetetrahydrofolate reductase genotype with macroangiopathy in type 2 diabetes mellitus.
The C677T methylenetetrahydrofolate reductase gene mutation in hemodialysis patients.
The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are associated with hyperhomocysteinemia and cardiovascular disease in hemodialysis patients.
Renal Insufficiency, Chronic
Decisive evidence corroborates a null relationship between MTHFR C677T and chronic kidney disease: A case-control study and a meta-analysis.
Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with advanced CKD and ESRD: a prospective study.
Effects of Italian Mediterranean organic diet vs. low-protein diet in nephropathic patients according to MTHFR genotypes.
Endothelial nitric oxide synthetase, methylenetetrahydrofolate reductase polymorphisms, and cardiovascular complications in Tunisian patients with nondiabetic renal disease.
Methylenetetrahydrofolate reductase C677T polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males.
MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study.
Relationship Between Gene Polymorphism of Methylenetetrahydrofolate Reductase C677T and Left Ventricular Hypertrophy in Chinese Patients with Chronic Kidney Disease.
[Remodeling of the cardiovascular system and development of chronic kidney disease in patients with metabolic syndrome and obesity: role of eNOS, subunit p22-phox of NADPH-oxidase and MTHFR genes].
Retinal Artery Occlusion
Branch retinal artery occlusion associated with compound heterozygous genotype for methylenetetrahydrofolate reductase.
Cumulative visual impact of two coagulability disorders: A case report.
Hyperbaric oxygen therapy in branch retinal artery occlusion in a 15-year-old boy with methylenetetrahydrofolate reductase mutation.
The role of hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with retinal artery occlusion.
Retinal Vein Occlusion
A 31 year old woman with essential hypertension grade III and branch retinal vein occlusion with homozygous C677T MTHFR hyperhomocysteinemia and high Lp(a) levels.
Association of methylenetetrahydrofolate reductase (A1298C and C677T) polymorphisms with retinal vein occlusion in Tunisian patients.
Association of retinal vein occlusion, homocysteine, and the thrombophilic mutations in a Turkish population: A case-control study.
Association study of high-frequency variants of MTHFR gene with retinal vein occlusion in a Spanish population.
Bilateral retinal vein occlusion associated with 5,10-methylenetetrahydrofolate reductase mutation.
Genetic determinants of fasting and post-methionine hyperhomocysteinemia in patients with retinal vein occlusion.
Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism, and risk of retinal vein occlusion: a meta-analysis.
Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism, and risk of retinal vein occlusion: an updated meta-analysis.
Homocysteine, MTHFR C677T gene polymorphism, folic acid and vitamin B 12 in patients with retinal vein occlusion.
Hyperhomocyst(e)inemia and MTHFR C677T genotypes in patients with central retinal vein occlusion.
Hyperhomocyst(e)inemia, but not methylenetetrahydrofolate reductase C677T mutation, as a risk factor in branch retinal vein occlusion.
Hyperhomocysteinemia and C677T MTHFR Genotype in Patients With Retinal Vein Thrombosis.
Hyperhomocysteinemia and the methylenetetrahydrofolate reductase 677C-T mutation in patients under 50 years of age affected by central retinal vein occlusion.
Hyperhomocysteinemia and the MTHFR C677T mutation in central retinal vein occlusion.
Hyperhomocysteinemia in central retinal vein occlusion in young adults.
Investigation of methylenetetrahydrofolate reductase C677T and factor V Leiden mutation as a genetic marker for retinal vein occlusion.
MEK Inhibitor-Associated Central Retinal Vein Occlusion Associated with Hyperhomocysteinemia and MTHFR Variants.
Methylenetetrahydrofolate reductase C677T mutation and risk of retinal vein thrombosis.
Methylenetetrahydrofolate reductase polymorphisms as risk factors for retinal venous occlusive disease: A literature review.
Molecular Analysis of Prothrombotic Gene Variants in Venous Thrombosis: A Potential Role for Sex and Thrombotic Localization.
MTHFR C677T homozygous mutation in a patient with pigmentary glaucoma and central retinal vein occlusion.
MTHFR C677T mutation in central retinal vein occlusion: a case-control study in Chinese population.
MTHFR C677T mutation, factor II G20210A mutation and factor V Leiden as risks factor for youth retinal vein occlusion.
Plasma homocysteine in patients with retinal vein occlusion.
PO-57 - Problems of diagnostics of rare localizations thrombosis in cancer patients.
Retinal vein occlusion associated with methylenetetrahydrofolate reductase mutation.
Sequential multiple retinal vein occlusions and transient ischemic attack in MTHFR polymorphism and protein S deficiency.
Thrombophilic mutations and risk of retinal vein occlusion.
Retinoblastoma
Association of MTHFR 677C>T, 1298A>C and MTR 2756A>G Polymorphisms with Risk of Retinoblastoma.
Association of MTHFR 677C?>?T, 1298A?>?C and MTR 2756A?>?G Polymorphisms with Susceptibility to Childhood Retinoblastoma: A Systematic Review and Met-Analysis.
Association study of the common polymorphisms in the folate-methionine pathway with retinoblastoma.
Choroidal infarction following ophthalmic artery chemotherapy.
MTR polymorphic variant A2756G and retinoblastoma risk in Brazilian children.
Oxidative Stress and Polymorphism in MTHFR SNPs (677 and 1298) in Paternal Sperm DNA is Associated with an Increased Risk of Retinoblastoma in Their Children: A Case-Control Study.
Polymorphism in MTHFR (at SNPs 677 and 1298) in Paternal Sperm DNA and Risk of Retinoblastoma in their Children.
Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake.
Retinopathy of Prematurity
Evaluation of Factor V Leiden, Prothrombin G20210A, MTHFR C677T and MTHFR A1298C gene polymorphisms in retinopathy of prematurity in a Turkish cohort.
Rheumatic Heart Disease
The MTHFR C677T polymorphism is associated with mitral valve rheumatic heart disease.
Rhinitis, Allergic
Methylenetetrahydrofolate Reductase gene polymorphism in children with allergic rhinitis.
Riboflavin Deficiency
Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes.
Rubella
Evaluation of etiology and pregnancy outcome in recurrent miscarriage patients.
Sacroiliitis
Sacroiliitis and muscle cramps in a healthy young man: some spearhead on MTHFR mutations.
Sarcoidosis
Pulmonary Embolism in a Sarcoidosis Patient Double Heterozygous for Methylenetetrahydrofolate Reductase Gene Polymorphisms and Factor V Leiden and Homozygous for the D-Allele of Angiotensin Converting Enzyme Gene.
Sarcoma
Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients.
Sarcopenia
Pilot Study on Genetic Associations With Age-Related Sarcopenia.
The MTHFR gene polymorphism is associated with lean body mass but not fat body mass.
Scleroderma, Systemic
Plasma homocysteine levels, the prevalence of methylenetetrahydrofolate reductase gene C677T polymorphism and macrovascular disorders in systemic sclerosis: risk factors for accelerated macrovascular damage?
Scoliosis
Severe scoliosis in a patient with severe methylenetetrahydrofolate reductase deficiency.
Seizures
Adolescence/adult onset MTHFR deficiency may manifest as isolated and treatable distinct neuro-psychiatric syndromes.
Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes.
Epilepsy control with carbamazepine monotherapy from a genetic perspective.
Interictal epileptiform discharges on electroencephalography in children with methylenetetrahydrofolate reductase (MTHFR) polymorphisms.
Methylenetetrahydrofolate reductase (MTHFR) deficiency and infantile epilepsy.
Methylenetetrahydrofolate reductase C677T-polymorphism and its association with alcohol withdrawal seizure.
Methylenetetrahydrofolate reductase deficiency in a patient with phenotypic findings of Angelman syndrome.
Neonatal sinovenous thrombosis associated with homozygous thermolabile methylenetetrahydrofolate reductase in both mother and infant.
Prenatal diagnosis for severe methylenetetrahydrofolate reductase deficiency by linkage analysis and enzymatic assay.
[Cystathionine betasynthase and MTHFR deficiencies in adults]
Sepsis
Portal Vein Thrombosis in a Preterm Newborn with Mutation of the MTHFR and PAI-1 Genes and Sepsis by Candida parapsilosis.
Sexually Transmitted Diseases
The Impact of MTHFR 1298 A?>?C and 677 C?>?T Gene Polymorphisms as Susceptibility Risk Factors in Cervical Intraepithelial Neoplasia Related to HPV and Sexually Transmitted Infections.
Shoulder Pain
Avascular Necrosis of the Humeral Head in a Patient with Methylenetetrahydrofolate Reductase 1 Gene Polymorphism: A Case Report.
Sickle Cell Trait
Recurrent cerebral venous thrombosis associated with heterozygote methylenetetrahydrofolate reductase C677T mutation and sickle cell trait without homocysteinemia: an autopsy case report and review of literature.
Sinus Thrombosis, Intracranial
Bilateral transverse sinus thrombosis secondary to a homozygous C677T MTHFR gene mutation.
Cerebral Venous and Sinus Thrombosis and Thrombophilic Mutations in Western Iran: Association With Factor V Leiden.
Cerebral venous sinus thrombosis in children with acute lymphoblastic leukemia carrying the MTHFR TT677 genotype and further prothrombotic risk factors.
Cerebral Venous Sinus Thrombosis Presenting as Transient Ischemic Attacks in a Case With Homozygous Mutations of MTHFR A1298C and CG677T.
Factor V Leiden, factor V Cambridge, factor II GA20210, and methylenetetrahydrofolate reductase in cerebral venous and sinus thrombosis: A case-control study.
Heterozygous MTHFR A1298C Mutation causing Cerebral Venous Sinus Thrombosis.
Inherited thrombophilic factors do not increase central venous catheter blockage in children with malignancy.
MTHFR Gene Polymorphisms and Cardiovascular Risk Factors, Clinical-Imagistic Features and Outcome in Cerebral Venous Sinus Thrombosis.
Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury.
Sjogren's Syndrome
MTHFR gene variants and non-MALT lymphoma development in primary Sjogren's syndrome.
Skin Abnormalities
A newborn case with perinatal-lethal Gaucher disease due to R463H homozygosity complicated by C677T homozygosity in the MTHFR gene.
Skin Diseases
Global and gene-specific DNA methylation and hydroxymethylation in human skin exposed and not exposed to sun radiation.
Skin Neoplasms
Genetics and nonmelanoma skin cancer in kidney transplant recipients.
Methylenetetrahydrofolate reductase gene polymorphisms and skin cancer risk: a meta-analysis.
Polymorphisms in the MTHFR and VDR genes and skin cancer risk.
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase in squamous cell carcinoma and basal cell carcinoma of the skin.
Skin Ulcer
Skin ulcers mimicking pyoderma gangrenosum in a patient with MTHFR polymorphism.
Sleep Apnea, Obstructive
Nutrigenetic genotyping study in relation to Sleep Apnea Clinical Score.
Sleep Initiation and Maintenance Disorders
Interaction between methylenetetrahydrofolate reductase C677T gene polymorphism and sleep duration on risk of stroke pathogenesis.
Small Cell Lung Carcinoma
Hierarchical clustering of lung cancer cell lines using DNA methylation markers.
Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer.
Spastic Paraplegia, Hereditary
Severe 5,10-methylenetetrahydrofolate reductase deficiency: a rare, treatable cause of complicated hereditary spastic paraplegia.
Severe methylenetetrahydrofolate reductase deficiency: clinical clues to a potentially treatable cause of adult-onset hereditary spastic paraplegia.
Spina Bifida Occulta
677C>T and 1298A>C polymorphisms of methylenetetrahydropholate reductase gene and biochemical parameters in Turkish population with spina bifida occulta.
Spinal Cord Diseases
Methylenetetrahydrofolate Reductase Deficiency as a Cause of Treatable Adult-onset Leukoencephalopathy and Myelopathy.
MTHFR C677T polymorphism is associated with methotrexate-induced myelopathy risk.
Reversible nitrous oxide myelopathy and a polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase.
Spinal Dysraphism
118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.
5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects.
Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c --> t methylenetetrahydrofolate reductase and 2756a --> g methionine synthase genotypes.
Association of Fetal MTHFR C677T Polymorphism with Susceptibility to Neural Tube Defects: A Systematic Review and Update Meta-Analysis.
Association of neural tube defects in children of mothers with MTHFR 677TT genotype and abnormal carbohydrate metabolism risk: a case-control study.
C677T mutation in methylenetetrahydrofolate reductase gene and neural tube defects: should Japanese women undergo gene screening before pregnancy?
Distribution of alleles of the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in familial spina bifida.
Elevated plasma total homocysteine and C677T mutation of the methylenetetrahydrofolate reductase gene in patients with spina bifida.
Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population.
Evaluation of infant methylenetetrahydrofolate reductase genotype, maternal vitamin use, and risk of high versus low level spina bifida defects.
Evaluation of the MTHFR C677T allele and the MTHFR gene locus in a German spina bifida population.
Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor.
Genetic association analyses of nitric oxide synthase genes and neural tube defects vary by phenotype.
Genetic variation associated with the occurrence and progression of neurological disorders.
Genomic structure and transcript variants of the human methylenetetrahydrofolate reductase gene.
Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida.
Methylenetetrahydrofolate reductase (MTHFR): incidence of mutations C677T and A1298C in Brazilian population and its correlation with plasma homocysteine levels in spina bifida.
Methylenetetrahydrofolate reductase (MTHFR): the incidence of mutations C677T and A1298C in the Ashkenazi Jewish population.
Methylenetetrahydrofolate reductase and spina bifida: evaluation of level of defect and maternal genotypic risk in Hispanics.
Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects.
Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida.
Relevance to spina bifida of mutated methylenetetrahydrofolate reductase.
Spina bifida, folate metabolism, and dietary folate intake in a Northern Canadian aboriginal population.
The 894G>T variant in the endothelial nitric oxide synthase gene and spina bifida risk.
The C677T mutation of the 5,10-methylenetetrahydrofolate reductase gene is a moderate risk factor for spina bifida in Italy.
Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans.
[Frequency of C677T polymorphism of 5, 10-methylenetetrahydrofolate reductase (MTHFR) in Chilean mothers of spina bifida cases and controls ]
[Vascular diseases, spina bifida and schizophrenia in a single family associated with the heterozygote mutation of the heat-sensitive variant of methylenetetrahydrofolate reductase]
Spinocerebellar Ataxias
One?carbon metabolism factor MTHFR variant is associated with saccade latency in Spinocerebellar Ataxia type 2.
Splenic Infarction
Acute complete splenic infarction in a patient with Hirschsprung's disease and literature review of complete splenic infarction.
Spondylitis, Ankylosing
Atherosclerosis in male patients with ankylosing spondylitis: the relation with methylenetetrahydrofolate reductase (C677T) gene polymorphism and plasma homocysteine levels.
The effect of IL-4 and MTHFR gene variants in ankylosing spondylitis.
Squamous Cell Carcinoma of Head and Neck
Association between 11 genetic polymorphisms in folate-metabolising genes and head and neck cancer risk.
Association between dietary folate intake and clinical outcome in head and neck squamous cell carcinoma.
Dietary folate is associated with p16(INK4A) methylation in head and neck squamous cell carcinoma.
Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms in oral squamous cell carcinoma in south-east Iran.
MTHFR C677T and A1298C polymorphisms as predictors of radiotherapy response in head and neck squamous cell carcinoma.
One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study.
Polymorphism in ADH and MTHFR genes in oral squamous cell carcinoma of Indians.
Polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and risk of head and neck squamous cell carcinoma.
Polymorphisms and haplotypes in methylenetetrahydrofolate reductase gene and head and neck squamous cell carcinoma risk.
The association between MTHFR gene polymorphisms (C677T, A1298C) and oral squamous cell carcinoma: A systematic review and meta-analysis.
[Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of laryngeal squamous cell carcinoma]
ST Elevation Myocardial Infarction
C677T polymorphism of the 5,10 MTHFR gene in young Mexican subjects with ST-elevation myocardial infarction.
Characteristics and Long-Term Prognosis of Patients ?35 Years of Age with ST Segment Elevation Myocardial Infarction and "Normal or Near Normal" Coronary Arteries.
Homozygosity of the TT methylenetetrahydrofolate reductase C677T genotype is an independent long-term predictor of cardiac death in patients with premature myocardial infarction.
Multiple gene polymorphisms predisposing to the prothrombotic state in an adolescent with acute myocardial infarction.
The Association of Hereditary Prothrombotic Risk Factors with ST-Elevation Myocardial Infarction.
Stillbirth
Factor V Leiden, pregnancy complications and adverse outcomes: the Hordaland Homocysteine Study.
Stomach Neoplasms
A Functional Variant at the miR-214 Binding Site in the Methylenetetrahydrofolatereductase Gene Alters Susceptibility to Gastric Cancer in a Chinese Han Population.
A Meta-Analysis: Methylenetetrahydrofolate Reductase C677T Polymorphism in Gastric Cancer Patients Treated with 5-Fu Based Chemotherapy Predicts Serious Hematologic Toxicity but Not Prognosis.
A retrospective comparative exploratory study on two Methylentetrahydrofolate Reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patients.
A systematic review of meta-analyses on gene polymorphisms and gastric cancer risk.
Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism in gastric cancer.
Aberrant DNA Methylation of P16, MGMT, hMLH1 and hMSH2 Genes in Combination with the MTHFR C677T Genetic Polymorphism in Gastric Cancer.
Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer.
Association between the MTHFR C677T polymorphism and gastric cancer susceptibility: A meta-analysis of 5,757 cases and 8,501 controls.
Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies.
Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis.
Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis patients without Helicobacter pylori infection: a case control study.
Association of the methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia.
Association Study between Folate Pathway Gene Single Nucleotide Polymorphisms and Gastric Cancer in Koreans.
Associations of the MTHFR rs1801133 polymorphism with gastric cancer risk in the Chinese Han population.
Decrease in gastric cancer susceptibility by MTHFR C677T polymorphism in Ardabil Province, Iran.
Diet folate, DNA methylation and polymorphisms in methylenetetrahydrofolate reductase in association with the susceptibility to gastric cancer.
Dietary folate and vitamin B12 intake before diagnosis decreases gastric cancer mortality risk among susceptible MTHFR 677TT carriers.
Dietary folate, one-carbon metabolism-related genes, and gastric cancer risk in Korea.
DNA Repair Gene and MTHFR Gene Polymorphisms as Prognostic Markers in Locally Advanced Adenocarcinoma of the Esophagus or Stomach Treated with Cisplatin and 5-Fluorouracil-Based Neoadjuvant Chemotherapy.
Evaluation of an Association of Blood Homocysteine Levels With Gastric Cancer Risk From 27 Case-Control Studies.
Folate intake along with genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase in patients with advanced gastric cancer.
Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis.
Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis.
Gastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers.
Genetic polymorphisms in folate metabolism and the risk of stomach cancer.
Genetic polymorphisms in folate-metabolizing genes associated with gastric cancer prognosis in northwest China subjects.
Genetic susceptibility to cancer: the role of polymorphisms in candidate genes.
Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism, and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls.
Impact of methylenetetrahydrofolate reductase C677T polymorphism on the risk of gastric cancer and its interaction with Helicobacter pylori infection.
Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site.
Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer.
Influences of ERCC1, ERCC2, XRCC1, GSTP1, GSTT1, and MTHFR polymorphisms on clinical outcomes in gastric cancer patients treated with EOF chemotherapy.
Involvement of genetic factors and lifestyle on the occurrence of colorectal and gastric cancer.
Knock-down of methylenetetrahydrofolate reductase reduces gastric cancer cell survival: an in vitro study.
Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review.
Methylenetetrahydrofolate reductase 677C/T gene polymorphism, gastric cancer susceptibility and genomic DNA hypomethylation in an at-risk Italian population.
Methylenetetrahydrofolate reductase 677C>T polymorphism and gastric cancer susceptibility in Mexico.
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility.
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer: a meta-analysis.
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population.
Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population.
Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer.
Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis.
Methylenetetrahydrofolate reductase polymorphisms and susceptibility to gastric cancer in Chinese populations: a meta-analysis.
Methylenetetrahydrofolate reductase polymorphisms/haplotypes and risk of gastric cancer: a case-control analysis in China.
MiR-22, regulated by MeCP2, suppresses gastric cancer cell proliferation by inducing a deficiency in endogenous S-adenosylmethionine.
MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review.
MTHFR C677T polymorphism and differential methylation status in gastric cancer: an association with Helicobacter pylori infection.
MTHFR C677T polymorphism contributes to the risk for gastric cancer.
MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: A meta-analysis.
MTHFR polymorphisms in gastric cancer and in first-degree relatives of patients with gastric cancer.
MTHFR polymorphisms involved in vitamin B12 deficiency associated with atrophic gastritis.
Polymorphism of methylenetetrahydrofolate reductase gene is associated with response to fluorouracil-based chemotherapy in Chinese patients with gastric cancer.
Polymorphism of TS 3'-UTR predicts survival of Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel.
Polymorphisms in ERCC1, GSTs, TS and MTHFR predict clinical outcomes of gastric cancer patients treated with platinum/5-Fu-based chemotherapy: a systematic review.
Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking.
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of stomach cancer in a Korean population.
Polymorphisms of 5,10-methylenetetralydrofolate reductase (MTHFR), fruit and vegetable intake, and the risk of stomach cancer.
Polymorphisms of MTHFD, plasma homocysteine levels, and risk of gastric cancer in a high-risk Chinese population.
Single nucleotide polymorphisms of one-carbon metabolism and cancers of the esophagus, stomach, and liver in a Chinese population.
The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition.
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and tumor risk: evidence from 134 case-control studies.
The polymorphism of methylenetetrahydrofolate reductase C677T but not A1298C contributes to gastric cancer.
The polymorphisms of TS and MTHFR predict survival of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population.
Thymidylate synthase and methylenetetrahy-drofolate reductase gene polymorphisms and gastric cancer susceptibility in a population of Northern Brazil.
Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.
[C677T polymorphism of the MTHFR gene and the risk of developing distal gastric cancer in a Mexican population]
[Clinical significance of thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in Korean patients with gastric cancer]
[Polymorphism of methylenetetrahydrofolate reductase and sensitivity of stomach cancer to fluoropyrimidine-based chemotherapy]
[Polymorphisms of methylenetetrahydrofolate reductase C677T and the risk of stomach cancer]
[The relationship between methylenetetrahydrofolate reductase gene polymorphism and microsatellite instability in gastric cancer]
Stomatitis
Methotrexate-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses.
Methylenetetrahydrofolate reductase and thymidylate synthase genotypes modify oral mucositis severity following hematopoietic stem cell transplantation.
PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy.
Predictors of oral mucositis in patients receiving hematopoietic cell transplants for chronic myelogenous leukemia.
Stomatitis, Aphthous
Association of MTHFR gene C677T mutation with recurrent aphthous stomatitis and number of oral ulcers.
Stroke
A child with Diamond-Blackfan anemia, methylenetetrahydrofolate reductase mutation, and perinatal stroke.
A clustering of unfavourable common genetic mutations in stroke cases.
A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease.
A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke.
A magnetic nanoparticles-based method for DNA extraction from the saliva of stroke patients.
A meta-analysis of the relationship between MTHFR gene A1298C polymorphism and the risk of adult stroke.
A novel multiplex PCR-RFLP method for simultaneous detection of the MTHFR 677 C > T, eNOS +894 G > T and - eNOS -786 T > C variants among Malaysian Malays.
A possible genetic link between MTHFR genotype and smoking behavior.
A prospective cohort study of MTHFR C677T gene polymorphism and its influence on the therapeutic effect of homocysteine in stroke patients with hyperhomocysteinemia.
A Study on Hereditary Thrombophilia and Stroke in a Cohort from Sri Lanka.
Acute stroke in relation to homocysteine and methylenetetrahydrofolate reductase gene polymorphisms.
Addressing optimal folate and related B-vitamin status through the lifecycle: health impacts and challenges.
Analysis of genetic polymorphisms related to thrombosis and other risk factors in patients with retinal vein occlusion.
Anesthesia for cesarean section in a patient with placenta previa and methylenetetrahydrofolate reductase deficiency.
Association between 5,10-Methylenetetrahydrofolate Reductase C677T Gene Polymorphism and Risk of Ischemic Stroke: A Meta-analysis.
Association between methylene tetrahydrofolate reductase polymorphisms and risk of ischemic stroke.
Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis.
Association of Homocysteine with Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.
Association of methylenetetrahydrofolate reductase gene C677T polymorphism with polycystic ovary syndrome risk: a systematic review and meta-analysis update.
Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype.
Association of the APOE, MTHFR and ACE Genes Polymorphisms and Stroke in Zambian Patients.
Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with stroke risk based on a meta-analysis.
Associations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption.
B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke.
C677T MTHFR mutation and factor V Leiden mutation in patients with TIA/minor stroke: a case-control study.
C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of ischemic stroke in Polish subjects.
Case-control Study of methylenetetrahydrofolate reductase mutations and hyperhomocysteinemia and risk of stroke.
Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in a Greek family.
Children with stroke: polymorphism of the MTHFR gene, mild hyperhomocysteinemia, and vitamin status.
Clinical presentation, etiology, and outcome of stroke in children: A hospital-based study.
Coexistence of Neurofibromatosis Type-1 and MTHFR C677T Gene Mutation in a Young Stroke Patient: A Case Report.
Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study.
Common mutations at the homocysteine metabolism pathway and pediatric stroke.
Congenital MTHFR deficiency causing early-onset cerebral stroke in a case homozygous for MTHFR thermolabile variant.
Connection between small vessel disease related stroke and the MTHFR C677T polymorphism in a Hungarian population.
Correlation of polymorphisms to coagulation and biochemical risk factors for cardiovascular diseases.
Correlation of the C677T MTHFR genotype with homocysteine levels in children with sickle cell disease.
Cumulative effect of predisposing genotypes and their interaction with modifiable factors on the risk of ischemic stroke in young adults.
Detailed analysis of gene polymorphisms associated with ischemic stroke in South asians.
Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis.
Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials.
Effect of folic acid supplementation on cancer risk among adults with hypertension in China: A randomized clinical trial.
Effect of gene-gene and gene-environment interaction on the risk of first-ever stroke and poststroke death.
Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke, but methylenetetrahydrofolate reductase gene C677T polymorphism was a risk factor for thrombotic stroke: a Multicenter Case-Control Study in China.
Evaluation of the interactions of common genetic mutations in stroke subtypes.
Factor V Leiden and antiphospholipid antibodies are significant risk factors for ischemic stroke in children.
Factor V Leiden, prothrombin 20210G-->A and the MTHFR C677T mutations in childhood stroke.
Folate, vitamin B12, and risk of ischemic and hemorrhagic stroke: a prospective, nested case-referent study of plasma concentrations and dietary intake.
Gene mutations and stroke in the young adult.
Genetic analysis of the thermolabile variant of 5, 10-methylenetetrahydrofolate reductase as a risk factor for ischemic stroke.
Genetic and nongenetic factors influencing plasma homocysteine levels in patients with ischemic cerebrovascular disease and in healthy control subjects.
Genetic polymorphisms of Chinese patients with ischemic stroke and concurrent stenoses of extracranial and intracranial vessels.
Genetic Risk Factors for Arterial Ischemic Stroke in Children: A Possible MTHFR and eNOS Gene-Gene Interplay?
Hereditary thrombophilic factors in stroke due to cerebral infarct.
Heterogeneity of Association Between MTHFR and Stroke Among European Regions: Additional Population Studies Are Needed in Italy.
High plasma homocysteine levels contribute to the risk of stroke recurrence and all-cause mortality in a large prospective stroke population.
Homocysteine and Stroke Risk: Modifying Effect of Methylenetetrahydrofolate Reductase C677T Polymorphism and Folic Acid Intervention.
Homocysteine and stroke: evidence on a causal link from mendelian randomisation.
Homocysteine, hypertension and stroke.
Homocysteine, small-vessel disease, and atherosclerosis: an MRI study of 825 stroke patients.
Homocystine levels, polymorphisms and the risk of ischemic stroke in young Asian Indians.
Homozygous MTHFR C677T gene mutation and recurrent stroke in an infant.
Homozygous thermolabile variant of the methylenetetrahydrofolate reductase gene: a potential risk factor for hyperhomocysteinaemia, CVD, and stroke in childhood.
Homozygous VN (677C to T) and d/D (2756G to A) variants in the methylenetetrahydrofolate and methionine synthase genes in a case of hyperhomocysteinemia with stroke at young age.
How to Understand Patent Foramen Ovale Clinical Significance: Part I.
Hyperhomocysteinemia, MTHFR 677C-->T polymorphism, and stroke.
Identification of genetic contribution to ischemic stroke by screening of single nucleotide polymorphisms in stroke patients by using a case control study design (Study protocol).
Inherited and acquired risk factors and their combined effects in pediatric stroke.
Inherited DNA mutations contributing to thrombotic complications in patients with sickle cell disease.
Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine.
Inherited thrombophilia and stratification of ischaemic stroke risk among users of oral contraceptives.
Inherited thrombophilia in childhood arterial stroke: data from Lebanon.
Inherited thrombophilia in pediatric ischemic stroke: an Egyptian study.
Interaction between methylenetetrahydrofolate reductase C677T gene polymorphism and sleep duration on risk of stroke pathogenesis.
Interaction of genetic risk factors confers higher risk for thrombotic stroke in male Chinese: a multicenter case-control study.
Interaction of homocysteine and conventional predisposing factors on risk of ischaemic stroke in young people: consistency in phenotype-disease analysis and genotype-disease analysis.
Interplay between 3'-UTR polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and the risk of ischemic stroke.
Lipoprotein (a) and genetic polymorphisms of clotting factor V, prothrombin, and methylenetetrahydrofolate reductase are risk factors of spontaneous ischemic stroke in childhood.
Malignant stroke in an adolescent with a homozygous MTHFR 677CT mutation and intake of hormonal contraceptives.
MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate.
Methylenetetrahydrofolate reductase C677T polymorphism, hypertension and risk of stroke: a prospective, nested case-control study.
Methylenetetrahydrofolate reductase gene polymorphism and childhood stroke.
Methylenetetrahydrofolate reductase gene polymorphism in Indian stroke patients.
Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: Dual effect of MTHFR polymorphisms C677T and A1298C.
Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients.
Methylentetrahydrofolate Reductase and Nitric Oxide Synthase Polymorphism in Patients with Atherosclerosis and Diabetes.
Microarray analysis of brain RNA in mice with methylenetetrahydrofolate reductase deficiency and hyperhomocysteinemia.
Migraine and MTHFR C677T genotype in a population-based sample.
Migraine mediates the influence of C677T MTHFR genotypes on ischemic stroke risk with a stroke-subtype effect.
Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland.
MTHFR 677 TT genotype and hyperhomocysteinaemia: an underestimated risk TANDEM for patients with stroke.
MTHFR C677T and A1298C polymorphisms and cerebral stroke in two twin gestations.
MTHFR C677T gene mutation as a risk factor for arterial stroke: a hospital based study.
MTHFR C677T polymorphism among Meiteis of Manipur (India).
MTHFR C677T polymorphism and its relation to ischemic stroke in the Black Sea Turkish population.
MTHFR C677T Polymorphism as a Risk Factor for Vascular Calcification in Chronic Hemodialysis Patients.
MTHFR gene polymorphism as a risk factor for silent brain infarcts and white matter lesions in the Japanese general population: The NILS-LSA Study.
Neonatal stroke associated with de novo antiphospholipid antibody and homozygous 1298C/C methylenetetrahydrofolate reductase mutation.
Pediatric stroke and methylenetetrahydrofolate reductase polymorphisms: an examination of C677T and A1298C mutations.
Pediatric Stroke, Homocysteine and MTHFR 677C-T and 1298 A-C.
Plasma homocysteine concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke.
Polymorphism of apoprotein E (APOE), methylenetetrahydrofolate reductase (MTHFR) and paraoxonase (PON1) genes in patients with cerebrovascular disease.
Posterior cerebral artery occlusion after Mycoplasma pneumoniae infection associated with genetic defect of MTHFR C677T.
Profile of prothrombotic factors in Indian children with ischemic stroke.
Prospective study of first stroke in relation to plasma homocysteine and MTHFR 677C>T and 1298A>C genotypes and haplotypes - evidence for an association with hemorrhagic stroke.
Prothrombotic Genetic Risk Factors in Stroke : A Possible Different Role in Pediatric and Adult Patients.
Prothrombotic polymorphisms, mutations, and their association with pediatric non-cardioembolic stroke in Asian-Indian patients.
Prothrombotic risk factors in the evaluation and management of perinatal stroke.
Quantitative assessment of association between rs1801133 polymorphism and susceptibility to stroke.
Recurrent small-artery disease in hyperhomocysteinemia: widowers' stroke syndrome?
Recurrent stroke in a patient with vitamin B12 deficiency and MTHFR mutation.
Red cell N5-methyltetrahydrofolate concentrations and C677T methylenetetrahydrofolate reductase genotype in patients with stroke.
Relationship between methylenetetrahydrofolate reductase (MTHFR) gene (A1298C) polymorphism with the risk of stroke: A systematic review and meta-analysis.
Relationship of MTHFR Gene 677C?T Polymorphism, Homocysteine, and Estimated Glomerular Filtration Rate Levels With the Risk of New-Onset Diabetes.
Role of a common mutation in the homocysteine regulatory enzyme methylenetetrahydrofolate reductase in ischemic stroke.
Role of Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C>T Polymorphism in Pediatric Cerebrovascular Disorders.
Shared genetic risk factors for depression and stroke.
ST-elevation myocardial infarction, pulmonary embolism, and cerebral ischemic stroke in a patient with critically low levels of natural anticoagulants.
Stroke following Glenn anastomosis in a child with inherited thrombophilia.
Stroke in Young Military Men With Heterozygous for MTHFR Gene Mutation or Factor V Leiden Gene Mutation Associated With Patent Foramen Ovale: Report of Two Cases and Therapeutic Strategy.
Symptomatic ischemic stroke in full-term neonates : role of acquired and genetic prothrombotic risk factors.
Synergistic effect of MTHFR C677T and F2 G20210A polymorphisms on ischemic stroke.
The Connotation of Variances in the Risk Predictors, Medications, Homocysteine, and Homocysteine Pathway Gene Polymorphisms with CVA/Stroke.
The importance of MTHFR polymorphisms in pediatric cerebral stroke.
The Methylenetetrahydrofolate Reductase C677T (rs1801133) and Apolipoprotein A5-1131T>C (rs662799) Polymorphisms, and Anemia Are Independent Risk Factors for Ischemic Stroke.
The methylenetetrahydrofolate reductase gene C677T polymorphism in patients with homozygous sickle cell disease and stroke.
The model homologue of the partially defective human 5,10-methylenetetrahydrofolate reductase, considered as a risk factor for stroke due to increased homocysteine level, can be protected and reactivated by heat shock proteins.
The modifying effect of the MTHFR genotype on the association between folic acid supplementation and pulse wave velocity: Findings from the CSPPT.
The MTHFR CT polymorphism confers a high risk for stroke in both homozygous and heterozygous T allele carriers with Type 2 diabetes.
The role of B vitamins in stroke prevention.
The role of classic risk factors and prothrombotic factor gene mutations in ischemic stroke risk development in young and middle-aged individuals.
The T allele of the 677C>T polymorphism of methylenetetrahydrofolate reductase gene is associated with an increased risk of ischemic stroke in Polish children.
The TT genotype of methylenetetrahydrofolate reductase 677C>T polymorphism increases the susceptibility to pediatric ischemic stroke: meta-analysis of the 822 cases and 1,552 controls.
The U-shaped relationship between serum methylene tetrahydrofolate reductase and large-artery atherosclerotic stroke.
Thrombophilia risk is not increased in children after perinatal stroke.
Thrombophilic predisposition in stroke and venous thromboembolism in Danish patients.
Two cousins with neonatal stroke, PAI-1 4G variant and MTHFR A1298C mutation.
Two siblings with a homozygous MTHFR C677T (G80A-RFC1) mutation and stroke.
Zinc Finger 259 Gene Polymorphism rs964184 is Associated with Serum Triglyceride Levels and Metabolic Syndrome.
[A case-control study on the relationship between stroke and plasma homocysteine level and the mutation of MTHFR gene.]
[A comparative analysis of allele frequencies of rs1801133 and rs1801131 of MTHFR in patients with stroke and healthy people from the Moscow region].
[Association study of renin-angiotensin system genes and hemostasis system genes with ischemic stroke among Russians of Central Russia].
[Case of juvenile stroke caused by methylenetetrahydrofolate reductase deficiency]
[Cystathionine betasynthase and MTHFR deficiencies in adults]
[Genetics of blood coagulation in young stroke patients]
[Hereditary thrombophilia with ischemiC stroke and sinus thrombosis. Diagnosis, therapy and meta-analysis]
[Hyperhomocysteine, methylenetetrahydrofolate reductase gene, and other risk factors in ischemic stroke]
[Increase of homocysteine in cardiovascular diseases in Hungary]
[Neonatal arterial ischemic stroke: Review of the current guidelines].
[Stroke and the genetics of hyperhomocysteinemia]
Stroke, Lacunar
A Patient with Combined CADASIL and MTHFR Homozygosity.
Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype.
Subacute Combined Degeneration
Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Subacute Combined Degeneration: Revealing a Genetic Predisposition.
Subarachnoid Hemorrhage
Methylenetetrahydrofolate reductase C677T variant and hyperhomocysteinemia in subarachnoid hemorrhage patients from India.
Syncope
Massive pulmonary embolism in a Lebanese patient doubly heterozygous for MTHFR and Factor V Leiden presenting with syncope and treated with tenecteplase.
t-plasminogen activator deficiency
Recurrent miscarriage syndrome and infertility due to blood coagulation protein/platelet defects: a review and update.
Tachycardia
Ischemic Stroke in a Patient With Atrial Tachycardia, Methylenetetrahydrofolate Reductase Mutation and New-Onset Atrial Fibrillation: Is Early Initiation of Anticoagulation Therapy Indicated?
Takayasu Arteritis
Takayasu arteritis with high titre of antiphospholipid antibodies and MTHFR Polymorphism.
Temporomandibular Joint Disorders
Association of Functional Polymorphisms in Matrix Metalloproteinase-9 and Glutathione S-Transferase T1 Genes with Temporomandibular Disorders.
Tension-Type Headache
The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine.
Tetralogy of Fallot
Genomics and Epigenomics of Congenital Heart Defects: Expert Review and Lessons Learned in Africa.
Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects.
MTHFR rs1801133 C>T polymorphism is associated with an increased risk of tetralogy of Fallot.
The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot.
Thrombasthenia
Glanzmann Thrombasthenia in a Newborn with Heterozygous Factor V Leiden and Heterozygous MTHFR C677T Gene Mutations.
Thromboangiitis Obliterans
A case of Buerger's disease associated with MTHFR C677T mutation homozygosity: a possible therapeutic support.
Stromelysin-1 5A/6A and eNOS T-786C Polymorphisms, MTHFR C677T and A1298C Mutations, and Cigarette-Cannabis Smoking: A Pilot, Hypothesis-Generating Study of Gene-Environment Pathophysiological Associations With Buerger's Disease.
Thrombocythemia, Essential
The relationship between factor V Leiden, prothrombin G20210A, and MTHFR mutations and the first major thrombotic episode in polycythemia vera and essential thrombocythemia.
Thrombophilic Risk of Factor V Leiden, Prothrombin G20210A, MTHFR, and Calreticulin Mutations in Essential Thrombocythemia Egyptian Patients.
Thrombocytopenia
A newborn case with perinatal-lethal Gaucher disease due to R463H homozygosity complicated by C677T homozygosity in the MTHFR gene.
Association of C677T and A1298C MTHFR Polymorphisms and Fluoropyrimidine-induced Toxicity in Mestizo Patients With Metastatic Colorectal Cancer.
Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes.
Gene-Gene Interactions of Gemcitabine Metabolizing-Enzyme Genes hCNT3 and WEE1 for Preventing Severe Gemcitabine-Induced Hematological Toxicity.
Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma.
Platelet receptor and clotting factor polymorphisms as genetic risk factors for thromboembolic complications in heparin-induced thrombocytopenia.
Possible roles of methylenetetrahydrofolate reductase polymorphism and folate status in patients with early hepatitis C virus genotype 4.
Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolism.
[Acute cerebral sinus-thrombosis due to polyangiitis overlap syndrome with granulomatosis with polyangiitis (Wegener's granulomatosis) and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)].
Thrombocytosis
Chronic Myeloid Leukemia with b3a3 (e14a3) Fusion: A Rare BCR/ABL Rearrangement Presenting with Thrombocytosis - Does MTHFR Polymorphism Matter.
Statistical Correlations of the Spontaneous Abortion with Trombophilia and Other Associated Pathologies.
Thromboembolic tendency (TE) in IBD (Inflammatory bowel disease) patients.
Thromboembolism
Arterial thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase C677T mutation in childhood membranous glomerulonephritis.
Case-control study of the frequency of thrombophilic disorders in couples with late foetal loss and no thrombotic antecedent--the Nîmes Obstetricians and Haematologists Study5 (NOHA5).
Classical familial homocystinuria in an adult presenting as an isolated lens subluxation.
Factor V Leiden, factor V Cambridge, factor II GA20210, and methylenetetrahydrofolate reductase in cerebral venous and sinus thrombosis: A case-control study.
Factor V Leiden, prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms and the risk of tamoxifen-associated thromboembolism in breast cancer patients.
Genetic risk factors in young adults with 'cryptogenic' ischemic cerebrovascular disease.
Red blood cell methylfolate and plasma homocysteine as risk factors for venous thromboembolism: a matched case-control study.
Review article: inherited thrombophilia in inflammatory bowel disease.
Role of soluble P-selectin and methylenetetrahydrofolate reductase gene polymorphisms (677C>T) in Egyptian patients with venous thromboembolism.
Segmental testicular ischaemia: presentation, management and follow-up.
Sequential multiple retinal vein occlusions and transient ischemic attack in MTHFR polymorphism and protein S deficiency.
The methylenetetrahydrofolate reductase gene polymorphism (C677T) is associated with increased cardiovascular mortality in Hungary.
The Methylenetetrahydrofolate Reductase Polymorphism (MTHFR c.677C>T) and Elevated Plasma Homocysteine Levels in a U.S. Pediatric Population with Incident Thromboembolism.
Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.
Thromboembolism in children.
Variant alleles in factor V, prothrombin, plasminogen activator inhibitor-1, methylenetetrahydrofolate reductase and risk of thromboembolism in metastatic colorectal cancer patients treated with first-line chemotherapy plus bevacizumab.
[Effect of hyperhomocysteinemia and methylenetetrahydrofolate reductase 677C --> T mutation in venous thromboembolism risk of young adults]
[Factor V Leiden, FII G20210A, MTHFR C677T mutations as risk factors for venous thrombosis during pregnancy and puerperium]
[Venous thromboembolism in a young patient. Diagnosis: Retinal vein thromboembolism in mutation of the methylenetetrahydrofolate reductase gene]
Thrombophilia
A 17-year-old male with pseudotumor cerebri secondary to performance-enhancing steroids triggering venous thrombosis in the brain.
A new PCR-SSP typing method for six single-nucleotide polymorphisms impairing the blood-clotting cascade as well as T-cell stimulation.
A review on clotting disorders and retinal hemorrhages: Can they mimic abuse?
A Study on Hereditary Thrombophilia and Stroke in a Cohort from Sri Lanka.
Absence of factor V Arg306--Thr and low factor V Arg306->Gly mutation prevalence in Thai blood donors.
ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing.
Acute ischemic stroke in a 7-month-old infant, risk factors, and diagnosis peculiarities: A case report.
Age and homocysteine plasma levels are risk factors for thrombotic complications after ovarian stimulation.
Amaurosis fugax caused by hereditary thrombophilia due to mutation of gene.
Amaurosis fugax: associations with heritable thrombophilia.
An uncommon clinical condition: chronic thrombosis of the inferior vena cava. A case report and review of literature.
Analysis of polymorphisms in genes (AGT, MTHFR, GPIIIa, and GSTP1) associated with hypertension, thrombophilia and oxidative stress in Mestizo and Amerindian populations of México.
Antiphospholipid antibodies in neonates with stroke--a unique entity or variant of antiphospholipid syndrome?
Association between in vitro fertilization outcomes and inherited thrombophilias: a meta-analysis.
Association of homocysteine, vitamin B12, folic acid, and MTHFR C677T in patients with a thrombotic event or recurrent fetal loss.
Association of MTHFR gene C677T mutation with recurrent aphthous stomatitis and number of oral ulcers.
Associations between Maternal and Fetal Inherited Thrombophilias, Placental Characteristics Associated with Vascular Malperfusion, and Fetal Growth.
Clinical Impact of Thrombophilia Screening in Young Adults with Ischemic Stroke.
Coagulation Biomarkers in Women with Recurrent Miscarriage and Polycystic Ovarian Syndrome: Systematic Review and Meta-Analysis.
Coexistence of the methylenetetrahydrofolate reductase single-nucleotide polymorphism (C677T) in patients with the factor V Leiden or prothrombin G20210A polymorphisms.
Combination of thrombophilia markers in acute myocardial infarction of the young.
Combined portal, splenic and mesenteric venous thrombosis in inactive ulcerative colitis with heterozygous mutation in MTHFR gene: A rare case of thrombophilia.
Common C677T polymorphism in the methylenetetrahydrofolate reductase gene increases the risk for deep vein thrombosis in patients with predisposition of thrombophilia.
Common C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of venous thromboembolism: meta-analysis of 31 studies.
Comparison of thrombophilic gene mutations among patients experiencing recurrent miscarriage and deep vein thrombosis.
Complicated Lemierre Syndrome Caused by Streptococcus gordonii and Possible Rickettsial Co-Infection in a Patient with Thrombophilia Predisposition.
Congenital thrombophilia associated to obstetric complications.
Correlation with Platelet Parameters and Genetic Markers of Thrombophilia Panel (Factor II g.20210G>A, Factor V Leiden, MTHFR (C677T, A1298C), PAI-1, ?-Fibrinogen, Factor XIIIA (V34L), Glycoprotein IIIa (L33P)) in Ischemic Strokes.
Dalteparin and low-dose aspirin in the prevention of adverse obstetric outcomes in women with inherited thrombophilia.
Defect of methylenetetrahydrofolate reductase in a patient with ten habitual misscarriages: a case report.
Detection of 677CT/1298AC "double variant" chromosomes: implications for interpretation of MTHFR genotyping results.
Development of a three-biosensor panel for the visual detection of thrombophilia-associated mutations.
Differentiation of antemortem pulmonary thromboembolism and postmortem clot with unenhanced MRI: a case report.
Do placental lesions reflect thrombophilia state in women with adverse pregnancy outcome?
Duplication of inferior vena cava and coagulation mutations with left-sided iliofemoral venous thrombosis.
Effects of inherited thrombophilia in women with recurrent pregnancy loss.
Efficacy and safety of nadroparin and unfractionated heparin for the treatment of venous thromboembolism during pregnancy and puerperium.
Etiological risk factors for subfertility among Palestinian women in Gaza.
Etiology of hypercoagulable state in women with recurrent fetal loss without other causes of miscarriage from Southern Italy: new clinical target for antithrombotic therapy.
Evaluation of Cases with Myotonia Congenita for Cardiovascular Risk.
Evaluation of Factor V Leiden, Prothrombin and Methylenetetrahydrofolate Reductase Gene Mutations in Patients with Severe Pregnancy Complications in Northern Finland.
Evaluation of GenoFlow Thrombophilia Array Test Kit in its detection of mutations in Factor V Leiden (G1691A), prothrombin G20210A, MTHFR C677T and A1298C in blood samples from 113 Turkish female patients.
Factor V Leiden, Prothrombin and MTHFR Mutation in Patients with Preeclamsia, Intrauterine Growth Restriction and Placental Abruption.
Fatal pulmonary thromboembolism and hereditary thrombophilias.
Free functional muscle transfer failure and thrombophilic gene mutations as a potential risk factor: a case report.
Frequency of selected thrombophilias in women with placental abruption.
Frequency of triple mutations involving factor v, prothrombin, and methylenetetrahydrofolate reductase genes among patients referred for molecular thrombophilia workup in a tertiary care center in Lebanon.
Genetic factors in fetal growth restriction and miscarriage.
Genetic thrombophilia in patients with VTE in eastern Mediterranean located tertiary care center; is it time to change the algorithm for thrombophilia work up decision making?
Genetic thrombophilias and intrauterine growth restriction: a meta-analysis.
Genetics of preeclampsia: what are the challenges?
Glanzmann Thrombasthenia in a Newborn with Heterozygous Factor V Leiden and Heterozygous MTHFR C677T Gene Mutations.
Henoch-Schonlein purpura: polymorphisms in thrombophilia genes.
Hereditary thrombophilia, anti-beta2 glycoprotein 1 IgM, and anti-annexin V antibodies in recurrent pregnancy loss.
Hereditary thrombophilic risk factors for recurrent pregnancy loss.
Hyperhomocysteinemia increases the risk of venous thrombosis independent of the C677T mutation of the methylenetetrahydrofolate reductase gene in selected Brazilian patients.
Impact of Factor V Leiden, prothrombin and methylenetetrahydrofolate reductase gene mutations on infant birth weight in women with recurrent fetal loss and women with successful pregnancies.
Impact of inherited thrombophilia on the risk of recurrent venous thromboembolism onset in georgian population.
Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies.
Implantation of left ventricular assist device complicated by undiagnosed thrombophilia.
Increased rates of thrombophilia in women with repeated IVF failures.
Inherited and acquired thrombophilias and poor pregnancy outcome: should we be treating with heparin?
Inherited risk factors for thrombophilia among children with Legg-Calvé-Perthes disease.
Inherited thrombophilia and anticoagulant therapy for women with reproductive failure.
Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study.
Inherited thrombophilia as a risk factor for the development of ischemic stroke in young adults.
Inherited thrombophilia in infertile women-implication in unexplained infertility.
Inherited thrombophilia with recurrent pregnancy loss in Turkish women--a real phenomenon?
Inherited thrombophilias are not increased in "idiopathic" small-for-gestational-age pregnancies.
Is thrombophilia a major risk factor for deep vein thrombosis of the lower extremities among Lebanese patients?
Ischemic stroke subtypes and thrombophilia in young and elderly Brazilian stroke patients admitted to a rehabilitation hospital.
Lack of Association between Recurrent Pregnancy Loss and Inherited Thrombophilia in a Group of Colombian Patients.
Livedoid vasculopathy: does hyperhomocysteinaemia play an aetiological role?
Low-molecular-weight heparin in women with repeated implantation failure.
Management and the pregnancy outcomes of patients positive for anti-parietal cell antibody.
Management of hereditary angioedema type I and homozygous MTHFR mutation during pregnancy.
May the morphological findings in the first-trimester abortion materials be indicative of inherited thrombophilia?
Meta-analysis of hypercoagulability genetic polymorphisms in perthes disease.
Methylenetetrahydrofolate Reductase C677T Polymorphism and Recurrent Pregnancy Loss Risk in Asian Population: A Meta-analysis.
Molecular pathophysiology of thrombotic states and their impact to laboratory diagnostics.
MTHFR C677T and Factor V Leiden in Recurrent Pregnancy Loss: A Study Among an Endogamous Group in North India.
MTHFR Gene Polymorphisms and Cardiovascular Risk Factors, Clinical-Imagistic Features and Outcome in Cerebral Venous Sinus Thrombosis.
Multifactorial Painful Leg Ulcers Due to Hyperhomocysteinemia, Plasminogen Activator Inhibitor-1 4G/5G Heterozygote Gene Mutation, and Beta Thalassemia Minor: A Case Report.
Multiplex amplicon genotyping by high-resolution melting.
Multiplex primer extension reaction and capillary electrophoresis to study the frequency of thrombophilia-related mutations in a spanish population.
NONICHEMIC CENTRAL RETINAL VEIN OCCLUSION ASSOCIATED WITH HEREDITARY THROMBOPHYLIA.
Ocular vascular thrombotic events: a diagnostic window to familial thrombophilia (compound factor v leiden and prothrombin gene heterozygosity) and thrombosis.
Ocular vascular thrombotic events: central retinal vein and central retinal artery occlusions.
Outcome after kidney transplantation in children with thrombotic risk factors.
PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis.
PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q, and Prothrombin 20210A in Splanchnic Vein Thrombosis: Analysis of Individual Patient Data From Three Prospective Studies.
Pathologic features of the placenta in women with severe pregnancy complications and thrombophilia.
PlA2 Polymorphism of Platelet Glycoprotein IIb/IIIa and C677T Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR), but Not Factor V Leiden and Prothrombin G20210A Polymorphisms, Are Associated with More Severe Forms of Legg-Calvé-Perthes Disease.
Polymorphism for mutation of cytosine to thymine at location 677 in the methylenetetrahydrofolate reductase gene is associated with recurrent early fetal loss.
Population study of thrombophilic markers and pharmacogenetic markers of warfarin prevalence in Bosnia and Herzegovina.
Portal and mesenteric vein thromboses in a patient with prothrombin G20210 mutation, elevated lipoprotein (a), and high factor VIII.
Preeclampsia and its interaction with common variants in thrombophilia genes.
Pregnancy outcome in patients with a history of recurrent spontaneous miscarriages and documented thrombophilias.
Prevalence and Multiplicity of Thrombophilia Genetic Polymorphisms of F V, MTHFR, F II, and PAI -I: A Cross-Sectional Study on a Healthy Jordanian Population.
Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR G677A among 594 thrombotic Jordanian patients.
Primary thrombophilia in Mexico. II. Factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase C677T polymorphism in thrombophilic Mexican mestizos.
Primary thrombophilia in Mexico: a single tertiary referral hospital experience.
Primer-engineered multiplex PCR-RFLP for detection of MTHFR C677T, prothrombin G20210A and factor V Leiden mutations.
Protein C and protein S deficiencies are the most important risk factors associated with thrombosis in Chinese venous thrombophilic patients in Taiwan.
Prothrombin 20210 G-->A, MTHFR C677T mutations in women with venous thromboembolism associated with pregnancy.
Prothrombotic inherited abnormalities other than factor V Leiden mutation do not play a role in venous thrombosis in inflammatory bowel disease.
Recurrent cerebral venous thrombosis associated with heterozygote methylenetetrahydrofolate reductase C677T mutation and sickle cell trait without homocysteinemia: an autopsy case report and review of literature.
Recurrent IVF failure and hereditary thrombophilia.
Recurrent miscarriage syndrome and infertility due to blood coagulation protein/platelet defects: a review and update.
Recurrent pregnancy loss in a subject with heterozygote factor V Leiden mutation; a case report.
Retinal vein occlusion in child with rare mutations in genes for thrombophilia.
Risk factors for thrombophilia in young adults presenting with thrombosis.
Risk Factors for Thrombosis Development in Mexican Patients.
Role of Polymorphisms in Factor V (FV Leiden), Prothrombin, Plasminogen Activator Inhibitor Type-1 (PAI-1), Methylenetetrahydrofolate Reductase (MTHFR) and Cystathionine ?-Synthase (CBS) Genes as Risk Factors for Thrombophilias.
Sequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population.
Severe 5,10-methylenetetrahydrofolate reductase deficiency and two MTHFR variants in an adolescent with progressive myoclonic epilepsy.
Severe arterial thrombophilia associated with a homozygous MTHFR gene mutation (A1298C) in a young man with Klinefelter syndrome.
Simultaneous genotyping of four single nucleotide polymorphisms associated with risk factors of hemostasis disorders.
Single inherited thrombophilias and adverse pregnancy outcomes.
Spontaneous pregnancies in patients with at least one failed IVF cycle after the management of autoimmune disorders, hereditary thrombophilia, and methylation disorders.
ST-elevation myocardial infarction, pulmonary embolism, and cerebral ischemic stroke in a patient with critically low levels of natural anticoagulants.
Statistical Correlations of the Spontaneous Abortion with Trombophilia and Other Associated Pathologies.
Sudden infant death syndrome, childhood thrombosis, and presence of genetic risk factors for thrombosis.
The 5, 10 methylenetetrahydrofolate reductase C677T mutation and risk of fetal loss: a case series and review of the literature.
The association between IUGR and maternal inherited thrombophilias: A case-control study.
The Association of Hereditary Prothrombotic Risk Factors with ST-Elevation Myocardial Infarction.
The Frequency of Some Thrombophilic Mutations in Eastern Turkey.
The prevalence of C677T mutation in the methylenetetrahydrofolate reductase gene and its association with venous thrombophilia in Taiwanese Chinese.
The Prevalence of Methylenetetrahydrofolate Reductase 677 C-T, Factor V 1691 G-A, and Prothrombin 20210 G-A Mutations in Healthy Populations in Setif, Algeria.
The relationship of mutations in the MTHFR, prothrombin, and PAI-1 genes to plasma levels of homocysteine, prothrombin, and PAI-1 in children and adults.
The role of point mutations in the genes, predisposing inherited thrombophilia in the pathogeneses of proximal and distal deep vein thrombosis in georgian population.
The thrombophilic network of autoantibodies in celiac disease.
The use of B vitamins for cutaneous ulcerations mimicking pyoderma gangrenosum in patients with MTHFR polymorphism.
Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis.
Thromboembolism in children.
Thrombophilia and pulmonary endarterectomy.
Thrombophilia in infancy: factor V Leiden and MTHFR or factor II double heterozygocity as a risk factor.
Thrombophilia in Patients With Lower Limbs Deep Veins Thrombosis (LDVT) Results of a Monocentric Survey on 103 Consecutive Outpatients.
Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage.
Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study.
Thrombophilia Profile in Budd-Chiari Syndrome and Splanchnic Vein Thrombosis: A Study from Western India.
Thrombophilia risk is not increased in children after perinatal stroke.
Thrombophilias and pregnancy complications: a case-control study.
Thrombophilias and recurrent miscarriage.
Thrombophilic genes alterations as risk factor for recurrent pregnancy loss.
Thrombophilic genotypes in subjects with idiopathic antiphospholipid antibodies--prevalence and significance.
Thrombophilic mutations in Iranian patients with infertility and recurrent spontaneous abortion.
Thrombosis of sinus sagitalis during puerperium caused by thrombophilic gene mutation.
Treatable high homocysteine alone or in concert with five other thrombophilias in 1014 patients with thrombotic events.
Unusual presentation of a sarcoid patient: multiple arterial and venous thrombosis with chest lymphadenopathy.
Venous Thromboembolism after Allogeneic Pediatric Hematopoietic Stem Cell Transplantation: A Single-Center Study.
Venous thrombosis and procoagulant factors in high-risk neuroblastoma.
Vocal Cord Paralysis as the First Sign of Spontaneous Carotid Dissection in a Patient With Extracranial Internal Carotid Artery Aneurysm.
[Allele polymorphism analysis in coagulation factors F2, F5 and folate metabolism gene MTHFR by using microchip-based multiplex real time PCR].
[Cerebral sinovenous thrombosis in a newborn with mutation of MTHFR C677T treated with enoxaparin].
[Cerebral venous thrombosis: when etiology makes the difference.]
[FETAL LOSSES DURING THE MATURATION OF THE PLACENTA AND THE RELATIONSHIP WITH SOME PROCOAGULANT CONDITIONS.]
[Genetic thrombophilic defects (Factor V Leiden, prothrombin G20210A, MTHFR C677T) in women with recurrent fetal loss]
[Greater saphenous vein thrombosis and testosterone replacement therapy: an occasional association?]
[Inherited thrombophilia and pregnancy]
[Intracardiac Thrombosis in a Child With Hereditary Thrombophilia].
[Massive pulmonary embolism in a patient with ulcerative colitis and hyperhomocysteinaemia -- a case report]
[Molecular methods in thrombophilic states diagnostics]
[Neonatal arterial ischemic stroke: Review of the current guidelines].
[Neonatal arterial ischemic stroke: Which thrombotic biological risk factors to investigate and which practical consequences?]
[Occurrence of gene mutations in factor V Leiden, prothrombin and methylenetetrahydrofolate reductase in patients with pre-eclampsia]
[Prevalence of methylenetetrahydrofolate reductase C677T mutation among patients with acute ischemic cerebrovascular disease in Aragon]
[The C677T mutation in the methylenetetrahydrofolate reductase gene and its association with deep vein thrombophilia in Shandong Hans]
[The role of 1691G>A (Leiden) mutation in Factor V gene, 20210G>A in prothrombin gene and 677C>T in MTHFR gene in etiology of early pregnancy loss].
[Thrombophilia, autoimmunity, and perioperative thromboprophylaxis]
Thrombophlebitis
Recurrent thrombophlebitis in a colon cancer patient with C677T heterozygous genotype for MTHFR treated with 5-fluorouracil-based adjuvant chemotherapy.
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase.
Thrombosis
A common mutation in the methylenetetrahydrofolate reductase gene (C677T) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V:Q506).
A new PCR-SSP typing method for six single-nucleotide polymorphisms impairing the blood-clotting cascade as well as T-cell stimulation.
A newborn case with perinatal-lethal Gaucher disease due to R463H homozygosity complicated by C677T homozygosity in the MTHFR gene.
Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors - a multicentre case-control study. For the Childhood Thrombophilia Study Group.
ABO blood groups and genetic risk factors for thrombosis in Croatian population.
Acquired activated protein C resistance, thrombophilia and adverse pregnancy outcomes: a study performed in an irish cohort of pregnant women.
Acute complete splenic infarction in a patient with Hirschsprung's disease and literature review of complete splenic infarction.
Adaptive developmental plasticity in methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism limits its frequency in South Indians.
Anesthesia for cesarean section in a patient with placenta previa and methylenetetrahydrofolate reductase deficiency.
Antiphospholipid antibodies in neonates with stroke--a unique entity or variant of antiphospholipid syndrome?
Aortic Thrombus and Acute Pulmonary Embolism in an Individual Heterozygous for the MTHFR C677-T Mutation.
Aortic thrombus and acute pulmonary embolism in an individual heterozygous for the MTHFR C677T mutation.
Are factor V and prothrombin mutations associated with increased risk of oral cancer?
Arterial thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase C677T mutation in childhood membranous glomerulonephritis.
Assessment of genetic risk factors for thromboembolic complications in adults with idiopathic nephrotic syndrome.
Association between polymorphism of MTHFR c.677C>T and risk of cardiovascular disease in Turkish population: a meta-analysis for 2.780 cases and 3.022 controls.
Association between the methylene tetrahydrofolate reductase gene C677T mutation and colchicine unresponsiveness in Behcet's disease.
Association between the methylenetetrahydrofolate reductase 677C>T polymorphism and the risk of secondary lymphoproliferative disease in patients with a first idiopathic thrombosis.
Association of allelic variants of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase with thrombosis or ocular involvement in Behçet's disease: A systematic review and meta-analysis.
Association of Genetic Variants with Hyperhomocysteinemia in Indian Patients with Thrombosis.
Association of Methylenetetrahydrofolate Reductase C677T Polymorphism with Hyperhomocysteinemia and Deep Vein Thrombosis in the Iranian Population.
Association of various point mutations as risk factors for synthetic graft thrombosis in African American hemodialysis patients.
AXILLARY ARTERY THROMBOSIS IN A NEWBORN HOMOZYGOUS FOR METHYLENETETRAHYDROFOLATE REDUCTASE (A1298C) MUTATION AND HETEROZYGOUS FOR FACTOR V LEIDEN (G506A) MUTATION.
Biventricular Thrombi in a Patient With Heart Failure With Severely Reduced Ejection Fraction and Heterozygous Prothrombin 20210G/A and Homozygous Methylenetetrahydrofolate Reductase 677C/T Mutations.
C677T substitution in the methylenetetrahydrofolate reductase gene as a risk factor for venous thrombosis and arterial disease in selected patients.
Calcified thrombosis of the inferior vena cava extending to renal veins in a newborn with homozygous MTHFR a1298c mutation.
Can screening for genetic markers improve peripheral artery bypass patency?
Cardiology patient pages. Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease.
Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase A1298C mutation in adult membranous glomerulonephritis.
Cerebral sinovenous thrombosis associated with MTHFR A1298C mutation in the newborn: a case report.
Cerebral sinovenous thrombosis in children: A single-center experience.
Cerebral vein thrombosis and mild hyperhomocysteinemia: three new cases.
Choroidal infarction following ophthalmic artery chemotherapy.
Cilioretinal artery: Vasculogenesis might be promoted by plasminogen activator inhibitor-1 5G allele.
Clinical significance of determining plasma homocysteine: case-control study on arterial and venous thrombotic patients.
Coagulopathies frequency in aseptic osteonecrosis patients.
Coexistence of prothrombic risk factors and its relation to left ventricular thrombus in acute myocardial infarction.
Coexistence of the methylenetetrahydrofolate reductase single-nucleotide polymorphism (C677T) in patients with the factor V Leiden or prothrombin G20210A polymorphisms.
Common C677T polymorphism in the methylenetetrahydrofolate reductase gene increases the risk for deep vein thrombosis in patients with predisposition of thrombophilia.
Compound heterozygosity for the C677T and A1298C mutations of the MTHFR gene in a case of hyperhomocysteinemia with recurrent deep thrombosis at young age.
Congenital prothrombotic disorders in children with peripheral venous and arterial thromboses.
Correlations between methylenetetrahydrofolate reductase gene polymorphisms and venous thromboembolism: A meta-analysis of 99 genetic association studies.
Could genetic analysis be useful in reducing cerebrovascular risk in hypertensive subjects with hyperhomocysteinemia and patent foramen ovale? A 2-year follow-up study.
Deep vein thrombosis after orthopedic surgery in a patient with type 1 von Willebrand disease and mutations in the MTHFR and beta-fibrinogen genes.
Deep venous thrombosis and thrombophilic mutations in western Iran: association with factor V Leiden.
Deletion polymorphism in the angiotensin-converting enzyme gene as a thrombophilic risk factor after hip arthroplasty.
Differences in the frequency of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene among the Lebanese population.
Do thrombophilic gene mutations have a role on thromboembolic events in cancer patients?
Dual mutation (MTHFR A1298C with PAI (4G) mutation) manifesting with bilateral lower limb gangrene in a neonate.
Early Thrombosis of a Mitral Annuloplasty Ring in a Patient with MTHFR and Factor V Leiden Mutations.
Easy, accurate and reliable screening for SNPs by ion pair/reverse phase HPLC: simultaneous detection of factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase C677T variants.
Effect of methylenetetrahydrofolate reductase 677 C-T, 1298 A-C, and 1317 T-C on factor V 1691 mutation in Turkish deep vein thrombosis patients.
Factor V Leiden and increased risk for arterial thrombotic disease in young Brazilian patients.
Free-floating thrombus of the carotid artery with a homozygous methylenetetrahydrofolate reductase gene mutation: a case report.
Frequency and association of 1691 (G>A) FVL, 20210 (G>A) PT and 677 (C>T) MTHFR with deep vein thrombosis in the population of Bosnia and Herzegovina.
Gene-gene and gene-environment interactions in mild hyperhomocysteinemia.
General anesthesia and methylenetetrahydrofolate reductase deficiency.
Genetic determinants of heritable venous thrombosis: genotyping methods for factor V(Leiden)A1691G, methylenetetrahydrofolate reductase C677T, prothrombin G20210A mutation, and algorithms for venous thrombosis investigations.
Genetic factors associated with thrombosis in pregnancy in a United States population.
Genetic polymorphism of 5,10-MTHFR reductase gene in offspring of patients with myocardial infarction.
Genetic variations observed in arterial and venous thromboembolism--relevance for therapy, risk prevention and prognosis.
Granulomatous reaction in mediastinal B-cell non-Hodgkin lymphoma and intracardiac thrombosis.
Heparin for the treatment of thrombosis in neonates.
Hereditary thrombophilia in ethnic omani patients.
Heterozygous methylenetetrahydrofolate reductase 677C-T gene mutation with mild hyperhomocysteinemia associated with intrauterine iliofemoral artery thrombosis.
Heterozygous MTHFR A1298C Mutation causing Cerebral Venous Sinus Thrombosis.
Heterozygous prothrombin 20210G/A mutation, associated with hyperhomocysteinemia, and homozygous methylenetetrahydrofolate reductase 677C/T mutation, in a patient with portal and mesenteric venous thrombosis.
High prevalence of thrombophilic genotypes in patients with acute mesenteric vein thrombosis.
Homocysteine, methylenetetrahydrofolate reductase polymorphism, antiphospholipid antibodies, and thromboembolic events in systemic lupus erythematosus: a retrospective cohort study.
How to Understand Patent Foramen Ovale Clinical Significance: Part I.
Hyperhomocysteinemia and C677T MTHFR Genotype in Patients With Retinal Vein Thrombosis.
Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase C677T Polymorphism in Cerebral Veno-sinus Thrombosis.
Hyperhomocysteinemia and MTHFR C677T homozygosity in a vegetarian male with sinovenous thrombosis of the brain.
Hyperhomocysteinemia and MTHFR C677T polymorphism in patients with portal vein thrombosis complicating liver cirrhosis.
Hyperhomocysteinemia and of Methylenetetrahydrofolate Reductase (C677T) Genetic Polymorphism in Patients with Deep Vein Thrombosis.
Hyperhomocysteinemia and the compound heterozygous state for methylene tetrahydrofolate reductase are independent risk factors for deep vein thrombosis among South Indians.
Hyperhomocysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient.
Hyperhomocysteinemia, low folate status, homozygous C677T mutation of the methylene tetrahydrofolate reductase and renal arterial thrombosis.
Impact of maternal methylenetetrahydrofolate reductase C677T polymorphism on intervillous and decidual pathology with pregnancy loss.
Impact of thrombophilic gene mutations on thrombosis risk in patients with gastrointestinal carcinoma.
Incidence of thrombophilia in patients with Gaucher disease.
Influence of genetic predisposition to thrombosis on natural history of acute promyelocytic leukaemia. MRC Adult Leukaemia Working Party.
Inherited thrombophilia: a possible cause of in utero vascular thrombosis in children with intestinal atresia.
Inherited thrombophilias in pregnant patients: detection and treatment paradigm.
Intra-operative detection of carotid free-floating thrombus in a symptomatic patient with a methylenetetrahydrofolate reductase gene mutation. Case report and literature review.
Intracardiac Thrombosis Involving All Four Cardiac Chambers after Extracardiac Membranous Oxygenation Associated with MTHFR Mutations.
Intrauterine upper limb ischemia associated with fetal thrombophilia: a case report and review of the literature.
Investigation of potential biomarkers for thrombosis related diseases in Turkish Cypriot population.
Klinefelter's Syndrome and Venous Thrombosis.
Legg-perthes disease and heritable thrombophilia.
Methylenetetrahydrofolate reductase (MTHFR) C677T mutation in Turkish patients with thrombosis.
Methylenetetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia in Budd-Chiari syndrome and portal vein thrombosis: A systematic review and meta-analysis of observational studies.
Methylenetetrahydrofolate reductase C677T mutation and risk of retinal vein thrombosis.
Methylenetetrahydrofolate Reductase C677T: Hypoplastic Left Heart and Thrombosis.
Methylenetetrahydrofolate Reductase Gene Polymorphism (C677T) as a Risk Factor for Arterial Thrombosis in Georgian Patients.
Methylenetetrahydrofolate reductase gene polymorphism and childhood stroke.
Methylenetetrahydrofolate reductase gene polymorphism: relation to blood pressure and cerebrovascular disease.
Methylenetetrahydrofolate reductase homozygous mutation in a young boy with cerebellar infarction.
Methylenetetrahydrofolate reductase polymorphism in healthy volunteers and its correlation with homocysteine levels in patients with thrombosis.
Mobile right heart thrombus as a manifestation of homozygous mutation of MTHFR 1298 A>C.
Molecular analysis of factor V Leiden, factor V Hong Kong, factor II G20210A, methylenetetrahydrofolate reductase C677T, and A1298C mutations related to Turkish thrombosis patients.
Molecular Analysis of Prothrombotic Gene Variants in Venous Thrombosis: A Potential Role for Sex and Thrombotic Localization.
MTHFR C677T mutations in liver cirrhosis with and without portal vein thrombosis.
MTHFR C677T polymorphism among Meiteis of Manipur (India).
MTHFR C677TT, PAI1 4G-4G, V Leiden Q506, and prothrombin G20210A in hepatocellular carcinoma with and without portal vein thrombosis.
Mutations in clotting factors and inflammatory bowel disease.
Neonatal sinovenous thrombosis associated with homozygous thermolabile methylenetetrahydrofolate reductase in both mother and infant.
No evidence for an increased risk of venous thrombosis in patients with factor V Leiden by the homozygous 677 C to T mutation in the methylenetetrahydrofolate-reductase gene.
Outcome of primary glomerular disease in pediatric renal transplantation: a single-center experience.
PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis.
PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q, and Prothrombin 20210A in Splanchnic Vein Thrombosis: Analysis of Individual Patient Data From Three Prospective Studies.
PAI-1 4G÷5G and MTHFR C677T polymorphisms increased the accuracy of two prediction scores for the risk of acute lower extremity deep vein thrombosis.
PO-57 - Problems of diagnostics of rare localizations thrombosis in cancer patients.
Polymorphisms in the methylenetetrahydrofolate reductase and methionine synthase reductase genes and homocysteine levels in Brazilian children.
Portal Vein Thrombosis in a Preterm Newborn with Mutation of the MTHFR and PAI-1 Genes and Sepsis by Candida parapsilosis.
Portal vein thrombosis in Egyptian patients with liver cirrhosis: Role of methylenetetrahydrofolate reductase C677T gene mutation.
Portomesenteric thrombosis after robotic sleeve gastrectomy.
Possible Association Between the Methylenetetrahydrofolate Reductase Gene C677T Polymorphism and Preexisting Portal Vein Thrombosis in Liver Transplant Recipients.
Prenatal diagnosis for severe methylenetetrahydrofolate reductase deficiency by linkage analysis and enzymatic assay.
Presumed pre- or perinatal arterial ischemic stroke: risk factors and outcomes.
Prevalence of factor V G1691A (Leiden), prothrombin G20210A, and methylene tetrahydrofolate reductase C677T thrombophilic mutations in children with inflammatory bowel disease.
Prevalence of factor V Leiden, FII G20210A, FXIII Val34Leu and MTHFR C677T polymorphisms in cancer patients with and without venous thrombosis.
Prevalence of factor V leiden, MTHFR C677T and MTHFR A1298C polymorphisms in patients with deep vein thrombosis in Central Iran.
Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR G677A among 594 thrombotic Jordanian patients.
Prevalence of hyperhomocysteinemia and the MTHFR C677T polymorphism in patients with arterial and venous thrombosis from North Western Russia.
Prevalence of methylenetetrahydrofolate reductase C677T and its association with arterial and venous thrombosis in the Chinese population.
Prevalence of prothrombin G20210A, factor V G1691A (Leiden), and methylenetetrahydrofolate reductase (MTHFR) C677T in seven different populations determined by multiplex allele-specific PCR.
Primary thrombophilia in Mexico. II. Factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase C677T polymorphism in thrombophilic Mexican mestizos.
Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphisms in pregnancy.
Protein C system defects in Indian children with thrombosis.
Prothrombin 20210A and oral contraceptive use as risk factors for cerebral venous thrombosis.
Prothrombotic factors in neonates with cerebral thrombosis and intraventricular hemorrhage.
Prothrombotic gene polymorphisms: possible contributors to hepatic artery thrombosis after orthotopic liver transplantation.
Prothrombotic genetic risk factors in young survivors of myocardial infarction.
Pulmonary Embolism in a Sarcoidosis Patient Double Heterozygous for Methylenetetrahydrofolate Reductase Gene Polymorphisms and Factor V Leiden and Homozygous for the D-Allele of Angiotensin Converting Enzyme Gene.
Recurrent cerebral venous thrombosis associated with heterozygote methylenetetrahydrofolate reductase C677T mutation and sickle cell trait without homocysteinemia: an autopsy case report and review of literature.
Recurrent thrombosis in a patient with pseudohomozygous activated protein C resistance and homozygosity for MTHFR gene polymorphism C677T.
Reduced in vivo oxidative stress following 5-methyltetrahydrofolate supplementation in patients with early-onset thrombosis and 677TT methylenetetrahydrofolate reductase genotype.
Role of Polymorphisms in Factor V (FV Leiden), Prothrombin, Plasminogen Activator Inhibitor Type-1 (PAI-1), Methylenetetrahydrofolate Reductase (MTHFR) and Cystathionine ?-Synthase (CBS) Genes as Risk Factors for Thrombophilias.
Screening for inherited thrombophilia might be warranted among Eastern Mediterranean sickle-beta-0 thalassemia patients.
Search for genetic factors favoring thrombosis in Turkish population.
Segmental renal artery thrombosis secondary to methylene tetrahydrofolate reductase mutation: an unusual presentation.
Significance of the use of the ViennaLab "Cardiovascular Disease panel" (CVD) Assay as a reflex test for the "Factor V/II/MTHFR Assay".
Splenic thrombosis in three patients with moderate hyperhomocysteinemia, low folate and the C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene.
Sudden infant death syndrome, childhood thrombosis, and presence of genetic risk factors for thrombosis.
The 19-bp deletion of dihydrofolate reductase (DHFR), methylenetetrahydrofolate reductase (MTHFR) C677T, Factor V Leiden, prothrombin G20210A polymorphisms in cancer patients with and without thrombosis.
The 677T genotype of the common MTHFR thermolabile variant and fasting homocysteine in childhood venous thrombosis.
The dose-response relation between serum homocysteine and cardiovascular disease: implications for treatment and screening.
The End of a Long Debate: Methylenetetrahydrofolate Reductase Gene Polymorphisms do not Increase Thrombosis Risk.
The frequency of factor V Leiden and concomitance of factor V Leiden with prothrombin G20210A mutation and methylene tetrahydrofolate reductase C677T gene mutation in healthy population of Denizli, Aegean region of Turkey.
The impact of the search for thrombophilia risk factors among antiphospholipid syndrome patients with thrombosis.
The influence of age, sex, vitamin B(12), folate levels and methylenetetrahydrofolate reductase C677T genetic mutations on plasma homocysteine in the Chinese population.
The Methylenetetrahydrofolate Reductase Polymorphism (MTHFR c.677C>T) and Elevated Plasma Homocysteine Levels in a U.S. Pediatric Population with Incident Thromboembolism.
The MTHFR 677TT and 677CT/1298AC genotypes in Cypriot patients may be predisposing to hypertensive nephrosclerosis and chronic renal failure.
The prevalence of C677T mutation in the methylenetetrahydrofolate reductase gene and its association with venous thrombophilia in Taiwanese Chinese.
The prevalence of factor V (G1691A), MTHFR (C677T) and PT (G20210A) gene mutations in arterial thrombosis.
The relationship between factor V Leiden, prothrombin G20210A, and MTHFR mutations and the first major thrombotic episode in polycythemia vera and essential thrombocythemia.
The relationship of mutations in the MTHFR, prothrombin, and PAI-1 genes to plasma levels of homocysteine, prothrombin, and PAI-1 in children and adults.
The Risk Factors for Thrombosis in Children With Acute Lymphoblastic Leukemia.
The Role of Factor V Leiden, Prothrombin G20210A, and MTHFR C677T Mutations in Neonatal Cerebral Sinovenous Thrombosis.
The role of point mutations in the genes, predisposing inherited thrombophilia in the pathogeneses of proximal and distal deep vein thrombosis in georgian population.
The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events.
Thromboembolic diseases in neonates and children.
Thromboembolism in newborns, infants and children.
Thrombophilia and pregnancy.
Thrombophilic factors are not the leading cause of thrombosis in Behçet's disease.
Thrombophilic genetic factors PAI-1 4G-4G and MTHFR 677TT as risk factors of alcohol, cryptogenic liver cirrhosis and portal vein thrombosis, in a Caucasian population.
Thrombophilic genotypes in subjects with idiopathic antiphospholipid antibodies--prevalence and significance.
Thrombophilic predisposition in stroke and venous thromboembolism in Danish patients.
Thrombosis in children with hematologic malignancies.
Thrombosis Related ABO, F5, MTHFR, and FGG Gene Polymorphisms in Morbidly Obese Patients.
Thrombotic genetic risk factors and warfarin pharmacogenetic variants in São Miguel's healthy population (Azores).
Thrombus obstructing the right ventricle outflow tract in a neonate with methylenetetrahydrofolate reductase 677TT genotype.
Thyroid vein thrombosis in a young woman with methylenetetrahydrofolate reductase gene mutation receiving cyproterone acetate/ethinylestradiol treatment for polycystic ovary syndrome: a case report.
Tricuspid valve thrombus and pulmonary embolus in an infant with homozygous thermolabile methylenetetrahydrofolate reductase and heterozygous prothrombin G20210A variant.
Venous thromboembolism, factor V Leiden, and methylenetetrahydrofolate reductase in a sickle cell anemia patient.
[Allele polymorphism analysis in coagulation factors F2, F5 and folate metabolism gene MTHFR by using microchip-based multiplex real time PCR].
[Cerebral sinovenous thrombosis in a newborn with mutation of MTHFR C677T treated with enoxaparin].
[Genetic trombophilia and markers of endotelial activation in patients with preeclampsia]
[Homocysteine, 5,10-methylenetetrahydrofolate reductase and deep venous thrombosis. Survey of 120 patients in internal medicine]
[Intracardiac Thrombosis in a Child With Hereditary Thrombophilia].
[Modern approaches to treatment of thrombosis in pregnant women, carriers of hereditary anomalies - f-v-leiden and g20210a mutation.]
[Mutation frequencies of the thrombophilic state genes in Uzbekistan]
[Mutation of a 5,10-methylenetetrahydrofolate reductase gene in systemic lupus erythematosis and antiphospholipid syndrome]
[Neonatal renal vein thrombosis in a heterozygous carrier of both factor V Leiden and the MTHFR gene mutation.]
[Phlebothrombosis and congenital thrombophilia].
[Portal and mesenteric vein thrombosis associated with hyperhomocysteinemia and pernicious anemia in a patient heterozygous for the MTHFR C677T mutation.]
[Study of the genetic markers of thrombosis in hypertensive patients of the title population in the Republic of Mordovia]
[Thrombophilic disorders in children and adolescents with portal vein thrombosis]
[Type I antithrombin deficiency as a cause of arterial and venous thrombosis in a family with severe thrombophilia]
Thrombotic Microangiopathies
The TT genotype of the C677T polymorphism in the methylentetrahydrofolate reductase as a risk factor in thrombotic microangiopathies: results from a pilot study.
Thrombotic Stroke
Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study.
Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke, but methylenetetrahydrofolate reductase gene C677T polymorphism was a risk factor for thrombotic stroke: a Multicenter Case-Control Study in China.
Interaction of genetic risk factors confers higher risk for thrombotic stroke in male Chinese: a multicenter case-control study.
Thymoma
Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis.
Thyroid Cancer, Papillary
Polymorphisms of methylenetetrahydrofolate reductase and glutathione S-transferase are not associated with the risk of papillary thyroid cancer in Korean population.
Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.
Thyroid Diseases
Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease.
MTHFR gene polymorphisms in hypothyroidism and hyperthyroidism among Jordanian females.
Significant Association Between MTHFR C677T Polymorphism and Thyroid Cancer Risk: Evidence from a Meta-Analysis.
Thyroid Neoplasms
An increased risk of differentiated thyroid carcinoma in Iran with the 677C?T homozygous polymorphism in the MTHFR Gene.
Association between MTHFR C677T polymorphism and thyroid cancer risk: a meta-analysis.
Association of the functional polymorphism C677T in the methylenetetrahydrofolate reductase gene with colorectal, thyroid, breast, ovarian, and cervical cancers.
Increased T-allele frequency of 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene in differentiated thyroid carcinoma.
Interaction between alcohol consumption and methylenetetrahydrofolate reductase polymorphisms in thyroid cancer risk: National Cancer Center cohort in Korea.
Polymorphisms in MTHFR, MTR, RFC1 and CßS genes involved in folate metabolism and thyroid cancer: a case-control study.
Significant Association Between MTHFR C677T Polymorphism and Thyroid Cancer Risk: Evidence from a Meta-Analysis.
The association between the C677T polymorphism in MTHFR gene and the risk of thyroid cancer: a meta-analysis.
Thyroiditis, Autoimmune
Statistical Correlations of the Spontaneous Abortion with Trombophilia and Other Associated Pathologies.
Thyrotoxicosis
Cerebral sinus venous thrombosis in a subject with thyrotoxicosis and MTHFR gene polymorphism.
Tremor
Homocystinuria Due to MTHFR Variant Presenting As Infantile Tremor Syndrome.
Triple Negative Breast Neoplasms
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China.
Trisomy 18 Syndrome
Maternal folate polymorphisms and the etiology of human nondisjunction.
[Association of MTHFR and MTRR genes polymorphisms with non-disjunctions of chromosomes 18 and 21].
Turner Syndrome
C677T and A1298C Polymorphisms of MTHFR Gene and Their Relation to Homocysteine Levels in Turner Syndrome.
Methylenetetrahydrofolate reductase gene polymorphisms in Egyptian Turner Syndrome patients.
Prevalence of the polymorphism MTHFR A1298C and not MTHFR C677T is related to chromosomal aneuploidy in Brazilian Turner Syndrome patients.
Urea Cycle Disorders, Inborn
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Uremia
Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients.
[Methylenetetrahydrofolate reductase gene polymorphism and plasma homocysteine levels in hemodialysing patients]
Urinary Bladder Neoplasms
Association between methylenetetrahydrofolate reductase gene rs1801131 A/C polymorphism and urinary tumors' susceptibility.
Association between MTHFR Ala222Val (rs1801133) polymorphism and bladder cancer susceptibility: a systematic review and meta-analysis.
Combined effect of NAT2, MTR and MTHFR genotypes and tobacco on bladder cancer susceptibility in Tunisian population.
Genetic polymorphisms of MTHFR and aberrant promoter hypermethylation of the RASSF1A gene in bladder cancer risk in a Chinese population.
Genetic susceptibility of methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C, and G1793A polymorphisms with risk for bladder transitional cell carcinoma in men.
Genetic susceptibility to cancer: the role of polymorphisms in candidate genes.
Genetic variation in Glutathione S-Transferase Omega-1, Arsenic Methyltransferase and Methylene-tetrahydrofolate Reductase, arsenic exposure and bladder cancer: a case-control study.
Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina.
Lack of association between MTHFR Ala222Val and Glu429Ala polymorphisms and bladder cancer risk: A meta-analysis of case-control studies.
Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: a population-based case-control study.
Methylenetetrahydrofolate reductase and methionine synthase polymorphisms and risk of bladder cancer in a Tunisian population.
MTHFR C677T and A1298C polymorphisms were associated with bladder cancer risk and disease progression: a meta-analysis.
MTHFR Gene Polymorphisms and Bladder Cancer Susceptibility: a Meta-Analysis Including Race, Smoking Status and Tumour Stage.
MTHFR Gene Polymorphisms in Bladder Cancer in the Turkish Population.
Polymorphisms in DNA repair and metabolic genes in bladder cancer.
Polymorphisms in NQO1 and the clinical course of urinary bladder neoplasms.
Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer.
Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian population.
Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study.
Polymorphisms of methylenetetrahydrofolate reductase and methionine synthase genes and bladder cancer risk: a case-control study with meta-analysis.
Quantitative assessment of the association between MHTFR C677T (rs1801133, Ala222Val) polymorphism and susceptibility to bladder cancer.
Smoking and polymorphisms in folate metabolizing genes and their effects on the histological stage and grade for bladder tumors.
Urolithiasis
Relationship of Cholelithiasis and Urolithiasis with Methylenetetrahydrofolate Reductase Polymorphisms.
Uterine Cervical Neoplasms
A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.
A relationship between methylenetetrahydrofolate reductase variants and the development of invasive cervical cancer.
Allelic variations in 5, 10-methylenetetrahydrofolate reductase gene and susceptibility to cervical cancer in Indian women.
Association between Methylenetetrahydrofolate Reductase C677T Polymorphism and Susceptibility to Cervical Cancer: A Meta-Analysis.
Association between MTHFR C677T, MTHFR A1298C and MS A2756G polymorphisms and risk of cervical intraepithelial neoplasia II/III and cervical cancer: A meta-analysis.
Association between the MTHFR A1298C polymorphism and risk of cancer: evidence from 265 case-control studies.
C677T polymorphism of methylenetetrahydrofolate reductase may contribute to cervical cancer risk in complete over-dominant model.
Cervical cancer with polymorphism in MTHFR C677T gene: a systematic review and meta-analysis.
Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12.
Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities.
Folate and choline metabolism gene variants and development of uterine cervical carcinoma.
Homocysteine levels are associated with cervical cancer independent of methylene tetrahydrofolate reductase gene (MTHFR) polymorphisms in Indian population.
Impact of methylenetetrahydrofolate reductase (MTHFR) codon (677) and methionine synthase (MS) codon (2756) on risk of cervical carcinogenesis in North Indian population.
Increase in the prevalence of the MTHFR 677 TT polymorphism in women born since 1959: potential implications for folate requirements.
Lack of association between methylenetetrahydrofolate reductase C677T polymorphism, HPV infection and cervical intraepithelial neoplasia in Brazilian women.
Methylenetetrahydrofolate reductase (MTHFR) and susceptibility for (pre)neoplastic cervical disease.
Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia.
Methylenetetrahydrofolate Reductase C677T Polymorphism and Cervical Cancer Risk: a Meta-Analysis.
Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to cervical cancer and cervical intraepithelial neoplasia: a meta-analysis.
Methylenetetrahydrofolate reductase polymorphism C677T is not associated to the risk of cervical dysplasia.
MTHFR C677T and A1298C polymorphisms and cervical carcinoma susceptibility: meta-analyses based on 4421 individuals.
MTHFR C677T polymorphism was an ethnicity-dependent risk factor for cervical cancer development: evidence based on a meta-analysis.
MTHFR/p53 polymorphisms as genetic factors for cervical intraepithelial neoplasia and cervical cancer in HPV-infected Mexican women.
Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer.
The association between MTHFR 677C>T polymorphism and cervical cancer: evidence from a meta-analysis.
The association between MTHFR polymorphism and cervical cancer.
The association between MTHFR polymorphisms and cervical cancer risk: a system review and meta analysis.
The effect of methylenetetrahydrofolate reductase polymorphism C677T on cervical cancer in Korean women.
The effect of methylenetetrahydrofolate reductase polymorphisms on susceptibility to human papilloma virus infection and cervical cancer.
The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women.
The SNP rs4846048 of MTHFR enhances the cervical cancer risk through association with miR-522: A preliminary report.
[Study on the relationship between the MTHFR polymorphism, the level of the folic acid and the cervical cancer susceptibility].
[The effect of MTHFR polymorphisms, pregnancy and first intercourse on cervical cancer in a population from the Northeastern Mexico]
Vaginosis, Bacterial
Polymorphisms in the MTHRF, VDR, MMP-9 and IL-? genes and the risk of premature rupture of membranes.
Socio-economic disparities in preterm birth: causal pathways and mechanisms.
Varicocele
Is methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism related with varicocele risk?
Varicose Veins
Incidence of the MTHFR polymorphisms in patients with varicose veins.
Morphology and Progression in Primary Varicose Vein Disorder Due to 677C>T and 1298A>C Variants of MTHFR.
MTHFR polymorphisms in primary varicose vein disorder.
Polymorphisms in the MTHFR and MTR genes and the risk of varicose veins in ethnical Russians.
Prevalence of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with varicose veins of lower limbs.
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase.
Vascular Calcification
MTHFR C677T Polymorphism as a Risk Factor for Vascular Calcification in Chronic Hemodialysis Patients.
Vascular Diseases
A C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism and G20210A mutation in the prothrombin gene of sickle cell anemia patients from Northeast Brazil.
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase.
A common haplotype for the 677T thermolabile variant of the 5,10-methylenetetrahydrofolate reductase gene in thrombophilic patients and controls.
A possible genetic link between MTHFR genotype and smoking behavior.
A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk.
A Structured-based Model for the Decreased Activity of Ala222Val and Glu429Ala Methylenetetrahydrofolate Reductase (MTHFR) Mutants.
Analysis of genetic polymorphism of methylenetetrahydrofolate reductase in a large ethnic Hakka population in southern China.
Analysis of the 677 C-->T mutation of the methylenetetrahydrofolate reductase gene in different ethnic groups.
C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular disease.
C677T MTHFR mutation and factor V Leiden mutation in patients with TIA/minor stroke: a case-control study.
C677T substitution in the methylenetetrahydrofolate reductase gene as a risk factor for venous thrombosis and arterial disease in selected patients.
Cardiac allograft vascular disease after orthotopic heart transplantation: methylenetetrahydrofolate reductase gene polymorphism C677T does not account for rapidly progressive forms.
Carriage of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism does not influence the first and second trimester uterine artery Doppler flow.
Case-control study of the frequency of thrombophilic disorders in couples with late foetal loss and no thrombotic antecedent--the Nîmes Obstetricians and Haematologists Study5 (NOHA5).
Cerebral sinovenous thrombosis associated with MTHFR A1298C mutation in the newborn: a case report.
Combined heterozygosity for methylenetetrahydrofolate reductase (MTHFR) mutations C677T and A1298C is associated with abruptio placentae but not with intrauterine growth restriction.
Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis.
Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine and other risk factors for vascular disease.
Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular disease.
Determinants of fasting and post-methionine homocysteine levels in families predisposed to hyperhomocysteinemia and premature vascular disease.
Does the polymorphism 677C-T of the 5,10-methylenetetrahydrofolate reductase gene contribute to homocysteine-related vascular disease?
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice.
Effect of MTHFR genotypes and hyperhomocysteinemia on patient and graft survival in kidney transplant recipients.
Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer.
Ethnic differences in the frequency of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in healthy Israeli populations.
Factor V Leiden and thermolabile methylenetetrahydrofolate reductase in extreme old age.
Fasting, postprandial, and post-methionine-load homocysteinaemia and methylenetetrahydrofolate reductase polymorphism in vascular disease.
Frequency of MTHFR G1793A polymorphism in individuals with early coronary artery disease: cross-sectional study.
Frequency of the 677 C-->T mutation of the methylenetetrahydrofolate reductase gene among Kuwaiti sickle cell disease patients.
Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae.
Genetic determinants of hyperhomocysteinaemia: the roles of cystathionine beta-synthase and 5,10-methylenetetrahydrofolate reductase.
Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis.
Genetic polymorphism of methylenetetrahydrofolate reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients.
Higher incidence of C677T polymorphism of the MTHFR gene in North Indian patients with vascular disease.
Homocysteine and human reproduction.
Homocysteine, folate, methylene tetrahydrofolate reductase genotype and vascular morbidity in diabetic subjects.
Homocysteine, hypertension and stroke.
Homocysteine, MTHFR gene polymorphisms, and cardio-cerebrovascular risk.
Hyperhomocysteinemia and polymorphisms of the methylenetetrahydrofolate gene in hemodialysis and peritoneal dialysis patients.
Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS)
Hyperhomocysteinemia, MTHFR, and risk of vascular disease.
Methylenetetrahydrofolate reductase (MTHFR) C677T mutation in Turkish patients with thrombosis.
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia.
Methylenetetrahydrofolate reductase (MTHFR): the incidence of mutations C677T and A1298C in the Ashkenazi Jewish population.
METHYLENETETRAHYDROFOLATE REDUCTASE C677T POLYMORPHISM IN PATIENTS WITH HENOCH-SCHÖNLEIN PURPURA.
Methylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic stroke.
Methylenetetrahydrofolate reductase gene polymorphism, homocysteine and risk of macroangiopathy in Type 2 diabetes mellitus.
Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinemia and occlusive retinal vascular disease in type 2 diabetic and non-diabetic subjects.
Methylenetetrahydrofolate reductase gene polymorphisms in 13 Chinese ethnic populations.
Methylenetetrahydrofolate reductase polymorphisms as risk factors for retinal venous occlusive disease: A literature review.
Migraine and coronary artery disease: an open study on the genetic polymorphism of the 5, 10 methylenetetrahydrofolate (MTHFR) and angiotensin I-converting enzyme (ACE) genes.
Migraine and genetic polymorphisms: an overview.
Molecular and clinical characterisation of homocystinuria in two Austrian families with cystathionine beta-synthase deficiency.
Molecular biology of 5,10-methylenetetrahydrofolate reductase.
MTHFR association with arteriosclerotic vascular disease?
MTHFR gene variant is not associated with diabetic nephropathy in Japanese.
Mutations of the MTHFR gene (428C>T and [458G>T+459C>T]) markedly decrease MTHFR enzyme activity.
Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolate reductase gene polymorphism.
Plasma homocysteine levels related to interactions between folate status and methylenetetrahydrofolate reductase: a study in 52 healthy subjects.
Polymorphism of the methylenetetrahydrofolate reductase gene association with homocysteine and ischemic stroke in type 2 diabetes.
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population.
Prevalence of hyperhomocysteinemia and the MTHFR C677T polymorphism in patients with arterial and venous thrombosis from North Western Russia.
Prevalence of the mutation C677 --> T in the methylene tetrahydrofolate reductase gene among distinct ethnic groups in Brazil.
Prevalence of variants in methylenetetrahydrofolate reductase and the severity of pulmonary vascular disease.
Role of Inherited Thrombophilia Risk Factors in Patients with CKD-5 Receiving Haemodialysis.
Sequential multiple retinal vein occlusions and transient ischemic attack in MTHFR polymorphism and protein S deficiency.
Serum folate, total homocysteine levels and methylenetetrahydrofolate reductase 677C>T polymorphism in young healthy female Japanese.
Serum homocysteine, MTHFR gene polymorphism, and carotid intimal-medial thickness in NIDDM subjects.
Study on homocysteine levels and methylenetetrahydrofolate reductase gene variant (C677T) in a population of Buenos Aires city.
Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation.
The (Ala-Val) mutation of methylenetetrahydrofolate reductase as a genetic risk factor for vascular disease in non-insulin-dependent diabetic patients.
The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine.
The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia.
The effect of MTHFR c.677C>T on plasma homocysteine levels depends on health, age and smoking.
The high prevalence of thermolabile 5-10 methylenetetrahydrofolate reductase (MTHFR) in Italians is not associated to an increased risk for coronary artery disease (CAD).
The influence of genetic and environmental factors on plasma homocysteine concentrations in a population at high risk for coronary artery disease.
The methylenetetrahydrofolate reductase 677 C-->T polymorphism and preeclampsia in two populations.
The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura.
The MTHFR C677T Polymorphism and Risk of Intracerebral Hemorrhage in a Chinese Han Population.
The relationship between the C677T polymorphism of the MTHFR gene and serum levels of luteinizing hormone in males with erectile dysfunction.
The thermolabile variant 677C-->T can further reduce activity when expressed in cis with severe mutations for human methylenetetrahydrofolate reductase.
Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.
Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease.
Thermolabile methylenetetrahydrofolate reductase, homocysteine, and cardiovascular disease risk: the European Concerted Action Project.
Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.
Wandering spleen: 'presentation in adolescent with high thrombotic risk'
[Genetic polymorphisms of methylenetetrahydrofolate reductase and methionine synthase: association with homocysteine metabolism and late-onset vascular diseases in the Japanese population]
[Genetic risk factors in senile dementia]
[Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in ischemic vascular disease]
[Polymorphism of the methylenetetrahydrofolate reductase gene (MTHFR) and incidence of hyperhomocysteinemia-related diseases]
[Polymorphisms in cystathionine beta-synthase and methylenetetrahydrofolate reductase genes as risk factors for cerebral vascular disease]
[Vascular diseases, spina bifida and schizophrenia in a single family associated with the heterozygote mutation of the heat-sensitive variant of methylenetetrahydrofolate reductase]
Vasculitis
Co-existence of renovascular hypertension, polyarteritis nodosa, antiphospholipid syndrome and methylenetetrahydrofolate reductase mutation.
Prediction of features of the course of chronic hepatitis C using Bayesian networks.
Venous Thromboembolism
A case control study on the contribution of factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations to the genetic susceptibility of deep venous thrombosis.
ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing.
Association between MTHFR C677T polymorphism and venous thromboembolism risk in the Chinese population: a meta-analysis of 24 case-controlled studies.
Association of MTHFR genetic polymorphisms with venous thromboembolism in Uyghur population in Xinjiang, China.
Association of Mycobacterium infections in patients with Mendelian susceptibility to mycobacterial disease with venous thromboembolism.
C677T methylenetetrahydrofolate reductase gene polymorphism as a risk factor involved in venous thromboembolism: a population-based case-control study.
C677T substitution in the methylenetetrahydrofolate reductase gene as a risk factor for venous thrombosis and arterial disease in selected patients.
Combined Effect of MTHFR C677T and PAI-1 4G/5G Polymorphisms on the Risk of Venous Thromboembolism in Chinese Lung Cancer Patients.
Common C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of venous thromboembolism: meta-analysis of 31 studies.
Correlations between methylenetetrahydrofolate reductase gene polymorphisms and venous thromboembolism: A meta-analysis of 99 genetic association studies.
Factor V G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T gene polymorphism in angiographically documented coronary artery disease.
Factor V Leiden, prothrombin 20210G --> A, methylenetetrahydrofolate reductase 677C --> T and plasminogen activator inhibitor 4G/5G polymorphism in women with pregnancy-related venous thromboembolism.
Factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations are not associated with chronic limb ischemia: the Linz Peripheral Arterial Disease (LIPAD) study.
Genetic polymorphism of methylenetetrahydrofolate reductase and venous thromboembolism: a case-control study.
Genetic polymorphisms associated with acute pulmonary embolism and deep venous thrombosis.
Genetic susceptibility to pregnancy-related venous thromboembolism: roles of factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations.
High prevalence of three prothrombotic polymorphisms among Palestinians: factor V G1691A, factor II G20210A and methylenetetrahydrofolate reductase C677T.
Homozygous methylentetrahydrofolate reductase C667T genotype anticipates age at venous thromboembolism by one decade.
Hyperhomocysteinemia and thrombosis: an overview.
Hyperhomocysteinemia increases the risk of venous thrombosis independent of the C677T mutation of the methylenetetrahydrofolate reductase gene in selected Brazilian patients.
Impact of inherited thrombophilia on the risk of recurrent venous thromboembolism onset in georgian population.
Inherited and acquired thrombophilias and poor pregnancy outcome: should we be treating with heparin?
Interaction between hyperhomocysteinemia and inherited thrombophilic factors in venous thromboembolism.
Is genetic screening necessary for determining the possibility of venous thromboembolism in cancer patients?
Lack of association between the C677T mutation in the 5,10-methylenetetrahydrofolate reductase gene and venous thromboembolism in Northwestern Greece.
Massive Pulmonary Embolism Associated With Factor V Leiden, Prothrombin, and Methylenetetrahydrofolate Reductase Gene Mutations in a Young Patient on Oral Contraceptive Pills: A Case Report.
Meta-analysis of the relationship between methylenetetrahydrofolate reductase C677T and A1298C polymorphism and venous thromboembolism in the Caucasian and Asian.
Methionine synthase A2756G and methylenetetrahydrofolate reductase A1298C polymorphisms are not risk factors for idiopathic venous thromboembolism.
Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study.
MTHFR A1298C and C677T Polymorphisms Are Associated with Increased Risk of Venous Thromboembolism: A Retrospective Chart Review Study.
No association of factor V Leiden, prothrombin G20210A, and MTHFR C677T gene polymorphisms with kidney allograft survival: a multicenter study.
Plasma homocysteine level and 677C-->T mutation on the MTHFR gene in patients with venous thromboembolism.
Prevalence of MTHFR C677T Single Nucleotide Polymorphism in Genetically Isolated Populations in Jordan.
Prothrombin 20210 G-->A, MTHFR C677T mutations in women with venous thromboembolism associated with pregnancy.
Prothrombotic risk factors in children with spontaneous venous thrombosis and their asymptomatic parents: a family study.
Role of soluble P-selectin and methylenetetrahydrofolate reductase gene polymorphisms (677C>T) in Egyptian patients with venous thromboembolism.
The 677C>T Mutation of the MTHFR Gene Increases the Risk of Venous Thromboembolism in Koreans and a Meta-Analysis From Asian Population.
The importance of homozygous polymorphisms of methylenetetrahydrofolate reductase gene in romanian patients with idiopathic venous thromboembolism.
The Methylenetetrahydrofolate Reductase Polymorphism (MTHFR c.677C>T) and Elevated Plasma Homocysteine Levels in a U.S. Pediatric Population with Incident Thromboembolism.
The prevalence of Factor V Leiden, prothrombin G20210A, MTHFR C677T and MTHFR A1298C mutations in healthy Turkish population.
The VITA project: C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism.
Thrombophilia and venous thromboembolism in pregnancy: a meta-analysis of genetic risk.
Thrombotic events revisited in children with acute lymphoblastic leukemia: impact of concomitant Escherichia coli asparaginase/prednisone administration.
Thyroid vein thrombosis in a young woman with methylenetetrahydrofolate reductase gene mutation receiving cyproterone acetate/ethinylestradiol treatment for polycystic ovary syndrome: a case report.
Venous thromboembolism associated with hyperhomocysteinemia, homozygosity for the methylenetetrahydrofolate reductase 677C>T gene variant, and secondary polycythemia.
Venous thromboembolism during pregnancy is not associated with persistent elevated activated protein C (APC) sensitivity ratio based on the endogenous thrombin potential.
Venous thromboembolism, factor V Leiden, and methylenetetrahydrofolate reductase in a sickle cell anemia patient.
[Association between gene polymorphisms of methylenetetrahydrofolate reductase and plasma homocysteine in Uygur patients with venous thromboembolism].
[Effect of hyperhomocysteinemia and methylenetetrahydrofolate reductase 677C --> T mutation in venous thromboembolism risk of young adults]
[Lowering high levels of fasting total homocysteine with folic acid and vitamins B in patients with venous thromboembolism: relationship between response and the C677T methylenetetrahydrofolate reductase (MTHRF) genotype]
[Relationship of plasma homocysteine and folic acid levels and 5,10-methylenetetrahydrofolate reductase gene mutation with venous thromboembolism]
[Venous thromboembolism in a young patient. Diagnosis: Retinal vein thromboembolism in mutation of the methylenetetrahydrofolate reductase gene]
Venous Thrombosis
A 17-year-old male with pseudotumor cerebri secondary to performance-enhancing steroids triggering venous thrombosis in the brain.
A boy with venous thrombosis, homozygous for factor V Leiden, prothrombin G20210A and MTHFR C667t mutations, but belonging to an asymptomatic family.
A case control study on the contribution of factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations to the genetic susceptibility of deep venous thrombosis.
A common mutation in the methylenetetrahydrofolate reductase gene (C677T) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V:Q506).
A second mutation in the methylenetetrahydrofolate reductase gene and the risk of venous thrombotic disease.
A study on thrombophilic factors in Italian Behcet's patients.
Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors - a multicentre case-control study. For the Childhood Thrombophilia Study Group.
Adaptive developmental plasticity in methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism limits its frequency in South Indians.
An unfavorable combination of Factor V Leiden with age, weight, and blood group causes high risk of pregnancy-associated venous thrombosis: a population-based nested case-control study.
Arterial thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase C677T mutation in childhood membranous glomerulonephritis.
Association between polymorphism of MTHFR c.677C>T and risk of cardiovascular disease in Turkish population: a meta-analysis for 2.780 cases and 3.022 controls.
Association of methylenetetrahydrofolate reductase (MTHFR-677 and MTHFR-1298) genetic polymorphisms with occlusive artery disease and deep venous thrombosis in Macedonians.
Association of Methylenetetrahydrofolate Reductase C677T Polymorphism with Hyperhomocysteinemia and Deep Vein Thrombosis in the Iranian Population.
Association study of methylenetetrahydrofolate reductase A1298C mutation with cerebral venous thrombosis risk in an Iranian population.
Association study of methylenetetrahydrofolate reductase C677T mutation with cerebral venous thrombosis in an Iranian population.
C677T substitution in the methylenetetrahydrofolate reductase gene as a risk factor for venous thrombosis and arterial disease in selected patients.
CBS 844ins68, MTHFR TT677 and EPCR 4031ins23 genotypes in patients with deep-vein thrombosis.
Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase A1298C mutation in adult membranous glomerulonephritis.
Cerebral sinus venous thrombosis in a subject with thyrotoxicosis and MTHFR gene polymorphism.
Cerebral Venous Thrombosis and Livedo Reticularis in a Case with MTHFR 677TT Homozygote.
Clinical Implications of Methylenetetrahydrofolate Reductase Mutations and Plasma Homocysteine Levels in Patients with Thromboembolic Occlusion.
Coexistence of left-sided inferior vena cava, deep vein thrombosis of the upper and lower extremities and prothrombotic polymorphisms in a young patient: a case report.
Common C677T polymorphism in the methylenetetrahydrofolate reductase gene increases the risk for deep vein thrombosis in patients with predisposition of thrombophilia.
Contraception-related deep venous thrombosis and pulmonary embolism in a 17-Year-old girl heterozygous for factor V leiden, prothrombin G20210A mutation, MTHFR C677T and homozygous for PAI-1 mutation: report of a family with multiple genetic risk factors and review of the literature.
Correlations between methylenetetrahydrofolate reductase gene polymorphisms and venous thromboembolism: A meta-analysis of 99 genetic association studies.
Deep vein thrombosis after orthopedic surgery in a patient with type 1 von Willebrand disease and mutations in the MTHFR and beta-fibrinogen genes.
Deep venous thrombosis and thrombophilic mutations in western Iran: association with factor V Leiden.
Deletion polymorphism in the angiotensin-converting enzyme gene as a thrombophilic risk factor after hip arthroplasty.
Detection of genomic polymorphisms associated with venous thrombosis using the invader biplex assay.
Easy, accurate and reliable screening for SNPs by ion pair/reverse phase HPLC: simultaneous detection of factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase C677T variants.
Effect of methylenetetrahydrofolate reductase 677 C-T, 1298 A-C, and 1317 T-C on factor V 1691 mutation in Turkish deep vein thrombosis patients.
Endocrine treatment of male-to-female transsexuals using gonadotropin-releasing hormone agonist.
Estrogen plus progestin and risk of venous thrombosis.
Evaluation of electronic microarrays for genotyping factor V, factor II, and MTHFR.
Factor V Leiden, prothrombin 20210A, methylenetetrahydrofolate reductase 677T, and population genetics.
Frequency and association of 1691 (G>A) FVL, 20210 (G>A) PT and 677 (C>T) MTHFR with deep vein thrombosis in the population of Bosnia and Herzegovina.
Genetic determinants of heritable venous thrombosis: genotyping methods for factor V(Leiden)A1691G, methylenetetrahydrofolate reductase C677T, prothrombin G20210A mutation, and algorithms for venous thrombosis investigations.
Genetic factors associated with thrombosis in pregnancy in a United States population.
Genetic polymorphisms and risk of recurrent deep venous thrombosis in young people: prospective cohort study.
Genetic variations observed in arterial and venous thromboembolism--relevance for therapy, risk prevention and prognosis.
Hereditary thrombophilia in ethnic omani patients.
High prevalence of factor V Leiden and prothrombin G20101A mutations in Kashmiri patients with venous thromboembolism.
High prevalence of thrombophilic genotypes in patients with acute mesenteric vein thrombosis.
Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies.
Homozygous cystathionine beta-synthase deficiency, combined with factor V Leiden or thermolabile methylenetetrahydrofolate reductase in the risk of venous thrombosis.
How to Understand Patent Foramen Ovale Clinical Significance: Part I.
Hyperhomocysteinemia and of Methylenetetrahydrofolate Reductase (C677T) Genetic Polymorphism in Patients with Deep Vein Thrombosis.
Hyperhomocysteinemia and thrombosis: an overview.
Hyperhomocysteinemia as a risk factor for venous thrombosis.
Hyperhomocysteinemia increases the risk of venous thrombosis independent of the C677T mutation of the methylenetetrahydrofolate reductase gene in selected Brazilian patients.
Hyperhomocysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient.
Hyperhomocysteinemia: clinical and therapeutical involvement in venous thrombosis.
Improved real-time multiplex polymerase chain reaction detection of methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C polymorphisms using nearest neighbor model-based probe design.
Influence of Amerindian mitochondrial DNA haplogroups on thrombosis susceptibility and frequency of four genetic prothrombotic variants in Southern Chilean subjects.
Inherited coagulation disorders in cirrhotic patients with portal vein thrombosis.
Inherited Thrombophilia in a Lebanese Family of Four Generations: A Case Report of Recurrent Miscarriage.
Interactions among methylenetetrahydrofolate reductase (MTHFR) and cystathionine ?-synthase (CBS) polymorphisms - a cross-sectional study: multiple heterozygosis as a risk factor for higher homocysteine levels and vaso-occlusive episodes.
Klinefelter's Syndrome and Venous Thrombosis.
Livedoid vasculopathy and hypercoagulability in a patient with primary Sjögren's syndrome.
Low folate levels and thermolabile methylenetetrahydrofolate reductase as primary determinant of mild hyperhomocystinemia in normal and thromboembolic subjects.
Lupus anticoagulant, factor V Leiden, and methylenetetrahydrofolate reductase gene mutation in a lupus patient with cerebral venous thrombosis.
Major and potential prothrombotic genotypes in patients with venous thrombosis and in healthy subjects from Slovenia.
Management of hereditary angioedema type I and homozygous MTHFR mutation during pregnancy.
Methylenetetrahydrofolate reductase (MTHFR-677 and MTHFR-1298) genotypes and haplotypes and plasma homocysteine levels in patients with occlusive artery disease and deep venous thrombosis.
Methylenetetrahydrofolate reductase C677T polymorphism, venous thrombosis, cardiovascular risk, and other effects.
Methylenetetrahydrofolate Reductase Deficiency: A Case Report.
Methylenetetrahydrofolate Reductase Gene Polymorphism (C677T) as a Risk Factor for Arterial Thrombosis in Georgian Patients.
Methylenetetrahydrofolate reductase polymorphism in healthy volunteers and its correlation with homocysteine levels in patients with thrombosis.
Mild hyperhomocysteinemia and MTHFR C677T do not increase the risk for venous thrombosis in a Spanish population.
Molecular Analysis of Prothrombotic Gene Variants in Venous Thrombosis: A Potential Role for Sex and Thrombotic Localization.
MTHFR C677T polymorphism and its relation to ischemic stroke in the Black Sea Turkish population.
Mutations in clotting factors and inflammatory bowel disease.
Mutations in coagulation factors in women with unexplained late fetal loss.
Myocardial infarction and venous thrombosis in a 42-year old woman with heterozygous methylenetetrahydrofolate reductase (MTHRF) gene mutation, hyperhomocysteinemia, and protein C deficiency.
No association between the common MTHFR 677C->T polymorphism and venous thrombosis: results from the MEGA study.
No evidence for an increased risk of venous thrombosis in patients with factor V Leiden by the homozygous 677 C to T mutation in the methylenetetrahydrofolate-reductase gene.
No interaction between factor V Leiden and hyperhomocysteinemia or MTHFR 677TT genotype in venous thrombosis. Results of a meta-analysis of published studies and a large case-only study.
PAI-1 4G÷5G and MTHFR C677T polymorphisms increased the accuracy of two prediction scores for the risk of acute lower extremity deep vein thrombosis.
Plasma homocysteine cutoff values for venous thrombosis.
Possible Association Between the Methylenetetrahydrofolate Reductase Gene C677T Polymorphism and Preexisting Portal Vein Thrombosis in Liver Transplant Recipients.
Prevalence of factor V Leiden, FII G20210A, FXIII Val34Leu and MTHFR C677T polymorphisms in cancer patients with and without venous thrombosis.
Prevalence of factor V leiden, MTHFR C677T and MTHFR A1298C polymorphisms in patients with deep vein thrombosis in Central Iran.
Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss.
Prevalence of genetic prothrombotic risk factors: 1691G > A FV, 20210G > A PT and 677C > T MTHFR mutations in the Bosnian population.
Prevalence of hyperhomocysteinemia and the MTHFR C677T polymorphism in patients with arterial and venous thrombosis from North Western Russia.
Prevalence of methylenetetrahydrofolate reductase C677T and its association with arterial and venous thrombosis in the Chinese population.
Prevalence of methylenetetrahydrofolate reductase mutations in patients with venous thrombosis.
Prevalence of prothrombin 20210A allele and methylenetetrahydrofolate reductase C677T genetic mutations in the Chinese population.
Prevalence of prothrombin G20210A, factor V G1691A (Leiden), and methylenetetrahydrofolate reductase (MTHFR) C677T in seven different populations determined by multiplex allele-specific PCR.
Prevalence of thrombophilic mutations in patients with unprovoked thromboembolic disease. A comparative analysis regarding arterial and venous disease.
Prospective study of homocysteine and MTHFR 677TT genotype and risk for venous thrombosis in a general population--results from the HUNT 2 study.
Protein C system defects in Indian children with thrombosis.
Prothrombin 20210 G-->A, MTHFR C677T mutations in women with venous thromboembolism associated with pregnancy.
Prothrombotic inherited abnormalities other than factor V Leiden mutation do not play a role in venous thrombosis in inflammatory bowel disease.
Recurrent cerebral venous thrombosis associated with heterozygote methylenetetrahydrofolate reductase C677T mutation and sickle cell trait without homocysteinemia: an autopsy case report and review of literature.
Relation of three genetic traits to venous thrombosis in an African-American population.
Relationship between genetic polymorphism of MTHFR C677T and lower extremities deep venous thrombosis.
Risk of Venous Thrombosis in Carriers of a Common Mutation in the Homocysteine Regulatory Enzyme Methylenetetrahydrofolate Reductase.
Role of methylenetetrahydrofolate reductase A1298C polymorphism in cerebral venous thrombosis.
Sickle cell disease: a multigenic perspective of a single-gene disorder.
Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury.
The 677T genotype of the common MTHFR thermolabile variant and fasting homocysteine in childhood venous thrombosis.
The C677T MTHFR variant and the risk of venous thrombosis.
The C677T mutation of the methylenetetrahydrofolate reductase gene is not associated with the risk of coronary artery disease or venous thrombosis among Chinese in Taiwan.
The dose-response relation between serum homocysteine and cardiovascular disease: implications for treatment and screening.
The G1691 --> A mutation of factor V, but not the G20210 --> A mutation of factor II or the C677 --> T mutation of methylenetetrahydrofolate reductase genes, is associated with venous thrombosis in patients with lupus anticoagulants.
The G20210A mutation of the prothrombin gene in patients with previous first episodes of deep-vein thrombosis: prevalence and association with factor V G1691A, methylenetetrahydrofolate reductase C677T and plasma prothrombin levels.
The methylenetetrahydrofolate reductase TT677 genotype is associated with venous thrombosis independently of the coexistence of the FV Leiden and the prothrombin A20210 mutation.
The MTHFR 677TT and 677CT/1298AC genotypes in Cypriot patients may be predisposing to hypertensive nephrosclerosis and chronic renal failure.
The prevalence of C677T mutation in the methylenetetrahydrofolate reductase gene and its association with venous thrombophilia in Taiwanese Chinese.
The prevalence of factor V (G1691A), MTHFR (C677T) and PT (G20210A) gene mutations in arterial thrombosis.
The role of genetics in coronary artery bypass surgery patients under 30 years of age.
The role of point mutations in the genes, predisposing inherited thrombophilia in the pathogeneses of proximal and distal deep vein thrombosis in georgian population.
Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis.
Thrombophilia.
Thrombophilic polymorphisms - factor V Leiden G1691A, prothrombin G20210A and MTHFR C677T - in Tunisian patients with cerebral venous thrombosis.
Thrombophilic predisposition in stroke and venous thromboembolism in Danish patients.
Venous thromboembolism in young patients from western India: a study.
Venous thromboembolism, factor V Leiden, and methylenetetrahydrofolate reductase in a sickle cell anemia patient.
[A common mutation C677T in the 5,10-methyltetrahydrofolate reductase gene is associated to idiopathic deep venous thrombosis]
[Antiphospholipid syndrome in the structure of hematogenic thrombophilia in young and middle-aged patients with venous thrombosis]
[C677T mutation in methylentetrahydrofolatereductase gene in patients with venous thromboses from the central region of Russia correlates with a high risk of pulmonary artery thromboembolism]
[Factor V Leiden, FII G20210A, MTHFR C677T mutations as risk factors for venous thrombosis during pregnancy and puerperium]
[Homocysteine levels and polymorphisms of MTHFR and CBS genes in Colombian patients with superficial and deep venous thrombosis]
[Homocysteine, 5,10-methylenetetrahydrofolate reductase and deep venous thrombosis. Survey of 120 patients in internal medicine]
[Hyperhomocysteinemia and deep-vein thrombosis]
[Mutation frequencies of the thrombophilic state genes in Uzbekistan]
[Phlebothrombosis and congenital thrombophilia].
[Study on the association of polymorphisms in homocysteine metabolism related enzymes with deep venous thrombosis]
[The C677T mutation in the methylenetetrahydrofolate reductase gene and its association with deep vein thrombophilia in Shandong Hans]
Vertebral Artery Dissection
Spontaneous Bilateral Vertebral Artery Dissection Secondary to PAI-1, MTHFR C677T and ACE Gene Mutations in a Young Man.
Virus Diseases
Lack of association between methylenetetrahydrofolate reductase C677T polymorphism, HPV infection and cervical intraepithelial neoplasia in Brazilian women.
The effect of methylenetetrahydrofolate reductase polymorphisms on susceptibility to human papilloma virus infection and cervical cancer.
Vitamin B 12 Deficiency
Association between MTHFR 677C>T Polymorphism and Vitamin B12 Deficiency: A Case-control Study.
Association between the MTHFR C677T polymorphism, blood folate and vitamin B12 deficiency, and elevated serum total homocysteine in healthy individuals in Yunnan Province, China.
Association of Vitamin B12 Deficiency with Homozygosity of the TT MTHFR C677T Genotype, Hyperhomocysteinemia, and Endothelial Cell Dysfunction.
Folate, folic acid and 5-methyltetrahydrofolate are not the same thing.
Hemolysis and hyperhomocysteinemia caused by cobalamin deficiency: three case reports and review of the literature.
High frequency of vitamin B12 deficiency in asymptomatic individuals homozygous to MTHFR C677T mutation is associated with endothelial dysfunction and homocysteinemia.
Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and the B-vitamins: a facet of nature-nurture interplay.
Hyperhomocysteinaemia, folate and vitamin B12 in unsupplemented haemodialysis patients: effect of oral therapy with folic acid and vitamin B12.
Hyperhomocysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient.
Methionine synthase deficiency without megaloblastic anaemia.
Methylenetetrahydrofolate Reductase Gene-specific Methylation and Recurrent Miscarriages: A Case- Control Study from North India.
Modulator Effects of the Methylenetetrahydrofolate Reductase C677T Polymorphism on Response to Vitamin B12 Therapy and Homocysteine Metabolism.
MTHFR polymorphisms involved in vitamin B12 deficiency associated with atrophic gastritis.
Recurrent stroke in a patient with vitamin B12 deficiency and MTHFR mutation.
Severe atherosclerosis in rheumatoid arthritis and hyperhomocysteinemia: is there a link?
Venous thromboembolism due to hyperhomocysteinaemia and tuberculosis.
Vitamin K Deficiency
The thrombophilic network of autoantibodies in celiac disease.
Vitiligo
Association Between Methylenetetrahydrofolate Reductase Gene Polymorphisms and Risk of Vitiligo: A Systematic Review and Meta-Analysis.
Association of elevated homocysteine levels and Methylenetetrahydrofolate reductase (MTHFR) 1298 A?>?C polymorphism with Vitiligo susceptibility in Gujarat.
Association of MTHFR C677T polymorphism with elevated homocysteine level and disease development in vitiligo.
Associations of methylenetetrahydrofolate reductase gene (MTHFR) rs1801131 and rs1801133 polymorphisms with susceptibility to vitiligo: A meta-analysis.
Estimation of Homocysteine Level and Methylenetetrahydrofolate Reductase (MTHFR) Gene and Cystathionine B Synthase (CBS) Gene Polymorphisms in Vitiligo Patients.
Evaluation of genotyping methods and costs for MTHFR, CBS and MTRR polymorphisms in patients with vitiligo.
Genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and risk of vitiligo in Han Chinese populations: a genotype-phenotype correlation study.
High incidence of MTHFR, CBS, and MTRR polymorphisms in vitiligo patients. Preliminary report in a retrospective study.
Methylenetetrahydrofolate reductase (MTHFR): could it be a small piece in vitiligo jigsaw puzzle?
Serum homocysteine, vitamin B12, folic acid levels and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in vitiligo.
von Willebrand Disease, Type 1
Deep vein thrombosis after orthopedic surgery in a patient with type 1 von Willebrand disease and mutations in the MTHFR and beta-fibrinogen genes.
von Willebrand Diseases
Deep vein thrombosis after orthopedic surgery in a patient with type 1 von Willebrand disease and mutations in the MTHFR and beta-fibrinogen genes.
Wilms Tumor
Impact of the MTHFR C677T polymorphism on risk of Wilms tumor: case-control study.
RFC-1 80G>A Polymorphism in Case-Mother/Control-Mother Dyads Is Associated with Risk of Nephroblastoma and Neuroblastoma.
Xanthomatosis, Cerebrotendinous
Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention.
Xeroderma Pigmentosum
Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy.
Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFOX-4 chemotherapy.
[methionine synthase] reductase deficiency
Defects in homocysteine metabolism: diversity among hyperhomocyst(e)inemias.
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase deficiency
Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.