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Information on EC 1.5.1.17 - alanopine dehydrogenase
for references in articles please use BRENDA:EC1.5.1.17
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EC Tree 1 Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.17 alanopine dehydrogenase
IUBMB Comments
In the reverse reaction, L-alanine can be replaced by L-cysteine, L-serine or L-threonine; glycine acts very slowly (cf. EC 1.5.1.22 strombine dehydrogenase).
The enzyme appears in viruses and cellular organisms
- 1.5.1.17
- analysis
- fulgidus
-
1.4.1.1
- archaeoglobus
- proteolyticus
-
cyclodeaminase
-
phormidium
- octopine
- diagnostics
showSynonyms
aladh, alanopine dehydrogenase, alpdh, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ADH
ALPDH
-
-
-
-
Dehydrogenase, alanopine
-
-
-
-
meso-N-(1-Carboxyethyl)-alanine dehydrogenase
-
-
-
-
ADH
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2,2'-iminodipropanoate + NAD+ + H2O = L-alanine + pyruvate + NADH + H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
pyruvate fermentation to opines
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SYSTEMATIC NAME
IUBMB Comments
2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)
In the reverse reaction, L-alanine can be replaced by L-cysteine, L-serine or L-threonine; glycine acts very slowly (cf. EC 1.5.1.22 strombine dehydrogenase).
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CAS REGISTRY NUMBER
COMMENTARY
71343-07-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,2'-iminodipropanoate + NAD+ + H2O
L-alanine + pyruvate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
beta-alanine + pyruvate + NADH + H+
beta-alanopine + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
r
glycine + pyruvate + NADH + H+
? + NAD+ + H2O
Substrates: reductive condensation, low activity
Products: -
Products: -
?
Gly + pyruvate + NADH
Strombine + NAD+ + H2O
-
Substrates: at 161.5% of the activity with L-Ala
Products: -
Products: -
?
Gly + pyruvate + NADH
Strombine + NAD+ + H2O
Busycotypus canaliculatum
-
Substrates: -
Products: -
Products: -
?
Gly + pyruvate + NADH
Strombine + NAD+ + H2O
-
Substrates: no activity
Products: -
Products: -
?
Gly + pyruvate + NADH
Strombine + NAD+ + H2O
-
Substrates: at 69% of the activity with L-Ala
Products: -
Products: -
?
Gly + pyruvate + NADH
Strombine + NAD+ + H2O
-
Substrates: at 9% of the activity with L-Ala
Products: -
Products: -
?
L-2-Aminobutyrate + pyruvate + NADH
?
-
Substrates: at 60% of the activity with L-Ala
Products: -
Products: -
?
L-2-Aminobutyrate + pyruvate + NADH
?
-
Substrates: at 94% of the activity with L-Ala
Products: -
Products: -
?
L-Ala + 2-oxobutanoate + NADH
?
-
Substrates: at 21% of the activity with pyruvate
Products: -
Products: -
?
L-Ala + 2-oxobutanoate + NADH
?
-
Substrates: at 68% of the activity with pyruvate
Products: -
Products: -
?
L-Ala + 2-oxobutanoate + NADH
?
-
Substrates: at 22% the activity with pyruvate
Products: -
Products: -
?
L-Ala + 2-oxobutanoate + NADH
?
-
Substrates: at 14% of the activity with pyruvate
Products: -
Products: -
?
L-Ala + 2-oxopentanoate + NADH
?
-
Substrates: at 25.6% of the activity with pyruvate
Products: -
Products: -
?
L-Ala + 2-oxopentanoate + NADH
?
-
Substrates: at 58% of the activity with pyruvate
Products: -
Products: -
?
L-Ala + glyoxylate + NADH
?
-
Substrates: at 10.5% of the activity with pyruvate
Products: -
Products: -
?
L-Ala + glyoxylate + NADH
?
-
Substrates: at 44% the activity with pyruvate
Products: -
Products: -
?
L-Ala + hydroxypyruvate + NADH
?
-
Substrates: at 12.8% of the activity with pyruvate
Products: -
Products: -
?
L-Ala + hydroxypyruvate + NADH
?
-
Substrates: at 3.3% of the activity with pyruvate
Products: -
Products: -
?
L-Ala + oxaloacetate + NADH
?
-
Substrates: at 106.6% of the activity with pyruvate
Products: -
Products: -
?
L-Ala + oxaloacetate + NADH
?
-
Substrates: as effective as pyruvate
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: r
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
Busycotypus canaliculatum
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: r
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: r
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
Dipolydora commensalis
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: r
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
Nucula nitida
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
Polydora glycymerica
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
Scolelepis fuliginosa
-
Substrates: -
Products: -
Products: -
?
L-alanine + pyruvate + NADH + H+
2,2'-iminodipropanoate + NAD+ + H2O
Substrates: reductive condensation, the enzyme is highy specific for L-alanine
Products: -
Products: -
?
L-alanine + pyruvate + NADH + H+
2,2'-iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
r
L-Cys + pyruvate + NADH
?
-
Substrates: at 130.8% of the activity with L-Ala
Products: -
Products: -
?
L-Cys + pyruvate + NADH
?
-
Substrates: at 90% of the activity with L-Ala
Products: -
Products: -
?
L-Cys + pyruvate + NADH
?
-
Substrates: at 110% of the activity with L-Ala
Products: -
Products: -
?
L-Ser + pyruvate + NADH
?
-
Substrates: at 150.8% of the activity with L-Ala
Products: -
Products: -
?
L-Ser + pyruvate + NADH
?
-
Substrates: at 90% of the activity with L-Ala
Products: -
Products: -
?
L-Ser + pyruvate + NADH
?
-
Substrates: at 67% of the activity with L-Ala
Products: -
Products: -
?
L-Thr + pyruvate + NADH
?
-
Substrates: as effective as L-Ala
Products: -
Products: -
?
L-Thr + pyruvate + NADH
?
-
Substrates: at 62% of the activity with L-Ala
Products: -
Products: -
?
L-Val + pyruvate + NADH
?
-
Substrates: at 71.5% of the activity with L-Ala
Products: -
Products: -
?
L-Val + pyruvate + NADH
?
-
Substrates: at 65% of the activity with L-Ala
Products: -
Products: -
?
additional information
?
-
Substrates: L-alanine binding region of alanopine dehydrogenase near a distinct helix-link-helix motif predicted by unbiased molecular dynamics simulations of ligand diffusion using a homology model of alanopine dehydrogenase, overview
Products: -
Products: -
?
additional information
?
-
-
Substrates: L-alanine binding region of alanopine dehydrogenase near a distinct helix-link-helix motif predicted by unbiased molecular dynamics simulations of ligand diffusion using a homology model of alanopine dehydrogenase, overview
Products: -
Products: -
?
additional information
?
-
Busycotypus canaliculatum
-
Substrates: the enzyme from hepatopancreas is involved in alanopine oxidation
Products: -
Products: -
?
additional information
?
-
Busycotypus canaliculatum
-
Substrates: muscle enzyme is involved in anaerobic glycolysis
Products: -
Products: -
?
additional information
?
-
-
Substrates: enzyme catalyzes the terminal step of anaerobic glycolysis during muscle anoxia associated with locomotion
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme probably functions in the maintenance of a redox balance during anaerobiosis in the adductor muscle and heart of the oyster
Products: -
Products: -
?
additional information
?
-
-
Substrates: D-strombine is not oxidized
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme functions in cytoplasmic redox balance during anoxia stress
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme functions as the terminal dehydrogenase of glycolysis and has a role in maintaining energy production under the stresses of environmental or functional anoxia
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,2'-iminodipropanoate + NAD+ + H2O
L-alanine + pyruvate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
beta-alanine + pyruvate + NADH + H+
beta-alanopine + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
r
L-alanine + pyruvate + NADH + H+
2,2'-iminodipropanoate + NAD+ + H2O
Substrates: reductive condensation, the enzyme is highy specific for L-alanine
Products: -
Products: -
?
L-alanine + pyruvate + NADH + H+
2,2'-iminodipropanoate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
r
additional information
?
-
Busycotypus canaliculatum
-
Substrates: the enzyme from hepatopancreas is involved in alanopine oxidation
Products: -
Products: -
?
additional information
?
-
Busycotypus canaliculatum
-
Substrates: muscle enzyme is involved in anaerobic glycolysis
Products: -
Products: -
?
additional information
?
-
-
Substrates: enzyme catalyzes the terminal step of anaerobic glycolysis during muscle anoxia associated with locomotion
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme probably functions in the maintenance of a redox balance during anaerobiosis in the adductor muscle and heart of the oyster
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme functions in cytoplasmic redox balance during anoxia stress
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme functions as the terminal dehydrogenase of glycolysis and has a role in maintaining energy production under the stresses of environmental or functional anoxia
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
cofactor binding region determination predicted by unbiased molecular dynamics simulations of ligand diffusion
-
additional information
-
cofactor binding region determination predicted by unbiased molecular dynamics simulations of ligand diffusion
-
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
the enzyme activity in adductor muscle decreases following the marine-brackish gradient
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
increased activity of alanopine dehydrogenase, ADH, and strombine dehydrogenase, SDH, enzymes in Montipora capitata exposed to prolonged durations of hypoxic conditions
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Infections
IFN-? and IL-2 Responses to Recombinant AlaDH against ESAT-6/CFP-10 Fusion Antigens in the Diagnosis of Latent versus Active Tuberculosis Infection.
Tuberculosis
Host vector system for high-level expression and purification of recombinant, enzymatically active alanine dehydrogenase of Mycobacterium tuberculosis.
Tuberculosis
IFN-? and IL-2 Responses to Recombinant AlaDH against ESAT-6/CFP-10 Fusion Antigens in the Diagnosis of Latent versus Active Tuberculosis Infection.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
430
Gly