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BRENDA support

Information on EC 1.5.4.1 - pyrimidodiazepine synthase

for references in articles please use BRENDA:EC1.5.4.1

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IUBMB Comments

In the reverse direction, the reduction of 6-pyruvoyl-tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring. The pyrimidodiazepine formed is an acetyldihydro derivative. Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster.

The expected taxonomic range for this enzyme is: Drosophila melanogaster

Synonyms
pda synthase, pyrimidodiazepine synthase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyltetrahydropterin + 2 glutathione
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
drosopterin and aurodrosopterin biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links