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Information on EC 1.5.5.2 - proline dehydrogenase

for references in articles please use BRENDA:EC1.5.5.2

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IUBMB Comments

A flavoprotein (FAD). The electrons from L-proline are transferred to the FAD cofactor, and from there to a quinone acceptor . In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 1.2.1.88, L-glutamate γ-semialdehyde dehydrogenase. Both activities are carried out by the same enzyme in enterobacteria.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
prodh, proline dehydrogenase, prodh/pox, prodh1, l-proline dehydrogenase, dye-linked l-proline dehydrogenase, puta flavoprotein, ttprodh, jcprodh, tcprodh, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol
show the reaction diagram