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Information on EC 1.5.7.2 - coenzyme F420 oxidoreductase (ferredoxin)
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The expected taxonomic range for this enzyme is: Methanosarcinales
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EC NUMBER 
COMMENTARY 
1.5.7.2
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RECOMMENDED NAME
GeneOntology No.
coenzyme F420 oxidoreductase (ferredoxin)
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
reduced coenzyme F420 + 2 oxidized ferredoxin = oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
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-
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SYSTEMATIC NAME
IUBMB Comments
coenzyme F420:ferredoxin oxidoreductase
The enzyme from the archaeon Methanosarcina mazei contains iron-sulfur centres and FAD.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
physiological function
additional information
evolution
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evolutionary trajectory of these oxidoreductases from a proton-reducing ancestral respiratory complex (ARC), overview. The diversification of ARC to membrane-bound hydrogenase (MBH), archaeal respiratory complex (MBX), FPO and eventually NADH quinone oxidoreductase (NUO) was driven by the larger energy yields associated with coupling ferredoxin oxidation to the reduction of oxidants with increasing electrochemical potential, including protons, S° and membrane soluble organic compounds such as phenazines and quinone derivatives. Phylogenetic tree. Homology between the subunits of FPOF and FPOC with those in MBX and MBH. Evolution of FPO, detailed overview. FPO is now present only in strictly anaerobic, acetate-utilizing and sulfate-reducing archaea
evolution
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evolutionary trajectory of these oxidoreductases from a proton-reducing ancestral respiratory complex (ARC), overview. The diversification of ARC to membrane-bound hydrogenase (MBH), archaeal respiratory complex (MBX), FPO and eventually NADH quinone oxidoreductase (NUO) was driven by the larger energy yields associated with coupling ferredoxin oxidation to the reduction of oxidants with increasing electrochemical potential, including protons, S° and membrane soluble organic compounds such as phenazines and quinone derivatives. Phylogenetic tree. Homology between the subunits of FPOF and FPOC with those in MBX and MBH. Evolution of FPO, detailed overview. FPO is now present only in strictly anaerobic, acetate-utilizing and sulfate-reducing archaea
physiological function
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the enzyme is a methanophenzine-reducing subunit of a methanogenic respiratory complex (FPO). These complexes also pump ions and have at least 10 homologous subunits in common. FPO uses either ferredoxin or cofactor F420. The FPO complex is mainly found in acetate-utilizing, methane-producing anaerobic Archaea where it functions to reduce the membrane-associated cofactor methanophenazine using either ferredoxin or the cytoplasmic cofactor F420
physiological function
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the enzyme is a methanophenzine-reducing subunit of a methanogenic respiratory complex (FPO). These complexes also pump ions and have at least 10 homologous subunits in common. FPO uses either ferredoxin or cofactor F420
additional information
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FPO demonstrates the flexible nature of the ARC-related complexes with respect to electron input and energetics reflected by differences in redox carriers and number of ions translocated
additional information
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FPO demonstrates the flexible nature of the ARC-related complexes with respect to electron input and energetics reflected by differences in redox carriers and number of ions translocated
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
methanophenazine + reduced F420 + 2 H+
reduced methanophenazine + oxidized F420
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-
-
-
?
methanophenazine + reduced ferredoxin + 2 H+
reduced methanophenazine + oxidized ferredoxin
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-
-
-
?
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
reduced coenzyme F420 + 2 oxidized ferredoxin
reduced coenzyme F420 + 2 oxidized ferredoxin
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
reduced coenzyme F420 + 2 oxidized ferredoxin
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-
-
r
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
reduced coenzyme F420 + 2 oxidized ferredoxin
FpoF can function as an ferredoxin:F420 oxidoreductase when reduced ferredoxin accumulates in the cytoplasm. As a soluble single subunit it is involved in the reoxidation of reduced ferredoxin in the cytoplasm, whereby reduced F420 is produced that is then reoxidized by the complete Fpo complex
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-
r
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
reduced coenzyme F420 + 2 oxidized ferredoxin
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-
-
r
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
reduced coenzyme F420 + 2 oxidized ferredoxin
FpoF can function as an ferredoxin:F420 oxidoreductase when reduced ferredoxin accumulates in the cytoplasm. As a soluble single subunit it is involved in the reoxidation of reduced ferredoxin in the cytoplasm, whereby reduced F420 is produced that is then reoxidized by the complete Fpo complex
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-
r
reduced coenzyme F420 + 2 oxidized ferredoxin
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
when the Fpo protein is connected to the membrane integral Fpo complex, it functions as an electron input module of the Fpo complex
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-
r
reduced coenzyme F420 + 2 oxidized ferredoxin
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
when the Fpo protein is connected to the membrane integral Fpo complex, it functions as an electron input module of the Fpo complex
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-
r
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
methanophenazine + reduced F420 + 2 H+
reduced methanophenazine + oxidized F420
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-
-
-
?
methanophenazine + reduced ferredoxin + 2 H+
reduced methanophenazine + oxidized ferredoxin
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-
-
-
?
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
reduced coenzyme F420 + 2 oxidized ferredoxin
reduced coenzyme F420 + 2 oxidized ferredoxin
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
reduced coenzyme F420 + 2 oxidized ferredoxin
Q8PZ67
FpoF can function as an ferredoxin:F420 oxidoreductase when reduced ferredoxin accumulates in the cytoplasm. As a soluble single subunit it is involved in the reoxidation of reduced ferredoxin in the cytoplasm, whereby reduced F420 is produced that is then reoxidized by the complete Fpo complex
-
-
r
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
reduced coenzyme F420 + 2 oxidized ferredoxin
Q8PZ67
FpoF can function as an ferredoxin:F420 oxidoreductase when reduced ferredoxin accumulates in the cytoplasm. As a soluble single subunit it is involved in the reoxidation of reduced ferredoxin in the cytoplasm, whereby reduced F420 is produced that is then reoxidized by the complete Fpo complex
-
-
r
reduced coenzyme F420 + 2 oxidized ferredoxin
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
Q8PZ67
when the Fpo protein is connected to the membrane integral Fpo complex, it functions as an electron input module of the Fpo complex
-
-
r
reduced coenzyme F420 + 2 oxidized ferredoxin
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
Q8PZ67
when the Fpo protein is connected to the membrane integral Fpo complex, it functions as an electron input module of the Fpo complex
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-
r
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Iron-sulfur cluster
presence of two FeS clusters, 8.7 mol of nonheme iron and 5.1 mol of acid-labile sulfur per mol of protein
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.002
oxidized coenzyme F420
pH 7.0, temperature not specified in the publication
0.0005
reduced ferredoxin
pH 7.0, temperature not specified in the publication
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
as a soluble single subunit it is involved in the reoxidation of reduced ferredoxin in the cytoplasm, whereby reduced F420 is produced that is then reoxidized by the complete Fpo complex
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as a soluble single subunit it is involved in the reoxidation of reduced ferredoxin in the cytoplasm, whereby reduced F420 is produced that is then reoxidized by the complete Fpo complex
-
when the Fpo protein is connected to the membrane integral Fpo complex, it functions as an electron input module of the Fpo complex
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when the Fpo protein is connected to the membrane integral Fpo complex, it functions as an electron input module of the Fpo complex
-
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
phylogenetic tree
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LINKS TO OTHER DATABASES (specific for EC-Number 1.5.7.2)
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