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Information on EC 1.5.8.2 - trimethylamine dehydrogenase
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EC Tree
1.5.8.2 trimethylamine dehydrogenaseIUBMB Comments
A number of alkyl-substituted derivatives of trimethylamine can also act as electron donors; phenazine methosulfate and 2,6-dichloroindophenol can act as electron acceptors. Contains FAD and a [4Fe-4S] cluster.
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Word Map
- 1.5.8.2
- flavin
- flavoproteins
- fmn
-
iron-sulfur
- semiquinone
- mononucleotide
- methylotrophus
- methylophilus
- dimethylamine
-
6-s-cysteinyl
- isoalloxazine
- ferricenium
-
flavocytochrome
-
nocardioides
-
flavinylation
-
fmn-binding
- tetramethylammonium
-
deflavo
- hyphomicrobium
- analysis
- nutrition
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
trimethylamine dehydrogenase, tmadh, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
EC 1.5.99.7
-
-
formerly
-
TMA dehydrogenase
TMADH
TMD
TMDH
TMADH
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
trimethylamine + H2O + electron-transfer flavoprotein = dimethylamine + formaldehyde + reduced electron-transfer flavoprotein
trimethylamine + H2O + electron-transfer flavoprotein = dimethylamine + formaldehyde + reduced electron-transfer flavoprotein
A number of alkyl-substituted derivates of trimethylamine can also act as electron donors. Phenazine methosulfate and 2,6-dichloroindophenol can act as electron acceptors
-
-
-
trimethylamine + H2O + electron-transfer flavoprotein = dimethylamine + formaldehyde + reduced electron-transfer flavoprotein
detailed reaction mechanism
-
trimethylamine + H2O + electron-transfer flavoprotein = dimethylamine + formaldehyde + reduced electron-transfer flavoprotein
redox mediation mechanism, overview
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
oxidative demethylation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)
A number of alkyl-substituted derivatives of trimethylamine can also act as electron donors; phenazine methosulfate and 2,6-dichloroindophenol can act as electron acceptors. Contains FAD and a [4Fe-4S] cluster.
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CAS REGISTRY NUMBER
COMMENTARY
39307-09-0
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-aminoethyldimethylamine + H2O + phenazine methosulfate
? + reduced phenazine methosulfate
2-chloroethyldimethylamine + H2O + phenazine methosulfate
? + reduced phenazine methosulfate
methylotrophic bacterium
-
40% of the activity compared to trimethylamine
-
?
2-hydroxyethyldimethylamine + H2O + phenazine methosulfate
? + reduced phenazine methosulfate
methylotrophic bacterium
-
70% of the activity compared to trimethylamine
-
?
diethylamine + H2O + phenazine methosulfate
ethylamine + acetaldehyde + reduced phenazine methosulfate
diethylmethylamine + H2O + electron acceptor
diethylamine + formaldehyde + reduced electron acceptor
diethylmethylamine + H2O + phenazine methosulfate
diethylamine + ethylmethylamine + formaldehyde + acetaldehyde + reduced phenazine methosulfate
ethyldimethylamine + H2O + phenazine methosulfate
ethylmethylamine + formaldehyde + reduced phenazine methosulfate
FMN + O2 + H2O
6-hydroxy-FMN + H2O2
-
reaction mechanism, reoxidation of the cofactor, mutant C30A enzyme, low activity with wild-type enzyme and mutant W355L
the hydroxy group oxygen is derived from molecular oxygen not from water
-
r
triethylamine + H2O + phenazine methosulfate
diethylamine + acetaldehyde + reduced phenazine methosulfate
methylotrophic bacterium
-
3% of the activity compared to trimethylamine
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
trimethylamine + H2O + alphaR237K mutant electron transferring flavoprotein
dimethylamine + formaldehyde + reduced alphaR237K mutant electron transferring flavoprotein
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
trimethylamine + H2O + electron-transfer flavoprotein
dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
trimethylamine + H2O + ferricenium hexafluorophosphate
dimethylamine + formaldehyde + ferrocenium hexafluorophosphate
trimethylamine + H2O + oxidized electron-transferring flavoprotein
dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
-
-
-
-
r
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
trimethylamine + H2O + semiquinone electron-transferring flavoprotein
dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
-
-
-
-
r
2-aminoethyldimethylamine + H2O + phenazine methosulfate
? + reduced phenazine methosulfate
methylotrophic bacterium
-
10% of the activity compared to trimethylamine
-
?
2-aminoethyldimethylamine + H2O + phenazine methosulfate
? + reduced phenazine methosulfate
methylotrophic bacterium 4B6
-
10% of the activity compared to trimethylamine
-
?
diethylamine + H2O + phenazine methosulfate
ethylamine + acetaldehyde + reduced phenazine methosulfate
-
-
-
?
diethylamine + H2O + phenazine methosulfate
ethylamine + acetaldehyde + reduced phenazine methosulfate
-
-
-
?
diethylamine + H2O + phenazine methosulfate
ethylamine + acetaldehyde + reduced phenazine methosulfate
methylotrophic bacterium
-
47% of the activity compared to trimethylamine
-
?
diethylamine + H2O + phenazine methosulfate
ethylamine + acetaldehyde + reduced phenazine methosulfate
methylotrophic bacterium 4B6
-
47% of the activity compared to trimethylamine
-
?
diethylmethylamine + H2O + electron acceptor
diethylamine + formaldehyde + reduced electron acceptor
-
slow substrate, triphasic reaction kinetic
-
?
diethylmethylamine + H2O + electron acceptor
diethylamine + formaldehyde + reduced electron acceptor
-
slow substrate, triphasic reaction kinetic
-
?
diethylmethylamine + H2O + phenazine methosulfate
diethylamine + ethylmethylamine + formaldehyde + acetaldehyde + reduced phenazine methosulfate
methylotrophic bacterium
-
11% of the activity compared to trimethylamine
-
?
diethylmethylamine + H2O + phenazine methosulfate
diethylamine + ethylmethylamine + formaldehyde + acetaldehyde + reduced phenazine methosulfate
methylotrophic bacterium 4B6
-
11% of the activity compared to trimethylamine
-
?
ethyldimethylamine + H2O + phenazine methosulfate
ethylmethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium
-
16% of the activity compared to trimethylamine
-
?
ethyldimethylamine + H2O + phenazine methosulfate
ethylmethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium 4B6
-
16% of the activity compared to trimethylamine
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
anaerobic growth conditions
-
?
trimethylamine + H2O + 2,6-dichlorophenolindophenol
dimethylamine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
anaerobic growth conditions
-
?
trimethylamine + H2O + alphaR237K mutant electron transferring flavoprotein
dimethylamine + formaldehyde + reduced alphaR237K mutant electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + alphaR237K mutant electron transferring flavoprotein
dimethylamine + formaldehyde + reduced alphaR237K mutant electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
ping-ping reaction mechanism
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
ping-ping reaction mechanism
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
methylotrophic bacterium
-
electron acceptors: phenazine methosulfate, brilliant cresyl blue, methylene blue
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
reducing equivalents transferred to electron transferring flavoprotein through the 4Fe-4S-center of trimethylamine dehydrogenase, not rate limiting during steady-state turnover
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
a series of conformational changes occur during assembly of the enzyme-electron transferring flavoprotein complex and electron transfer
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
physiological electron acceptor, biphasic reaction kinetic
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
physiological electron acceptor, biphasic reaction kinetic
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
physiological electron acceptor, biphasic reaction kinetic
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
reducing equivalents transferred to electron transferring flavoprotein through the 4Fe-4S-center of trimethylamine dehydrogenase, not rate limiting during steady-state turnover
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
a series of conformational changes occur during assembly of the enzyme-electron transferring flavoprotein complex and electron transfer
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
physiological electron acceptor, biphasic reaction kinetic
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron-transfer flavoprotein
dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron-transfer flavoprotein
dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + ferricenium hexafluorophosphate
dimethylamine + formaldehyde + ferrocenium hexafluorophosphate
-
-
-
?
trimethylamine + H2O + ferricenium hexafluorophosphate
dimethylamine + formaldehyde + ferrocenium hexafluorophosphate
-
-
-
?
trimethylamine + H2O + FMN
dimethylamine + formaldehyde + FMNH2
-
-
-
-
?
trimethylamine + H2O + FMN
dimethylamine + formaldehyde + FMNH2
-
-
-
-
r
trimethylamine + H2O + FMN
dimethylamine + formaldehyde + FMNH2
-
reaction mechanism
-
-
r
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
requires the addition of 3 reducing equivalents per subunit for complete reduction
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
requires the addition of 3 reducing equivalents per subunit for complete reduction
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium 4B6
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium 4B6
-
-
-
?
trimethylamine + H2O + phenazine methosulfate
dimethylamine + formaldehyde + reduced phenazine methosulfate
methylotrophic bacterium C2A1
-
-
-
?
additional information
?
-
-
recycling of the prosthetic electron-transferring group FMN by ferricinium, ferrocenedicarboxylic acid, ferrocenemonocarboxylic acid, ferrocenedimathanol, (dimethylamino)methylene ferrocene, and with lower activity by ferricyanide, no electron-transfer activity with 2,6-dichlorophenolindophenol, and thionine
-
-
?
additional information
?
-
-
does not reduce the alphaR237C, alphaR237E, and alphaR237A mutant electron transferring flavoproteins
-
-
?
additional information
?
-
-
does not reduce the alphaR237C, alphaR237E, and alphaR237A mutant electron transferring flavoproteins
-
-
?
additional information
?
-
-
versatile metabolic pathways for the degradation of trimethylamine, phylogenetic analysis of the Paracoccus strains
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
diethylmethylamine + H2O + electron acceptor
diethylamine + formaldehyde + reduced electron acceptor
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
trimethylamine + H2O + electron-transfer flavoprotein
dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
additional information
?
-
-
versatile metabolic pathways for the degradation of trimethylamine, phylogenetic analysis of the Paracoccus strains
-
-
?
diethylmethylamine + H2O + electron acceptor
diethylamine + formaldehyde + reduced electron acceptor
-
slow substrate, triphasic reaction kinetic
-
?
diethylmethylamine + H2O + electron acceptor
diethylamine + formaldehyde + reduced electron acceptor
-
slow substrate, triphasic reaction kinetic
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
ping-ping reaction mechanism
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
ping-ping reaction mechanism
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
-
-
-
?
trimethylamine + H2O + electron acceptor
dimethylamine + formaldehyde + reduced electron acceptor
methylotrophic bacterium
-
electron acceptors: phenazine methosulfate, brilliant cresyl blue, methylene blue
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
-
-
?
trimethylamine + H2O + electron transferring flavoprotein
dimethylamine + formaldehyde + reduced electron transferring flavoprotein