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Information on EC 1.5.99.4 - nicotine dehydrogenase

for references in articles please use BRENDA:EC1.5.99.4

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IUBMB Comments

A metalloprotein (FMN). The enzyme can act on both the naturally found (S)-enantiomer and the synthetic (R)-enantiomer of nicotine, with retention of configuration in both cases .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
nicotinic acid hydroxylase, nicotine dehydrogenase, ndhab, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor
show the reaction diagram