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Disease on EC 1.6.1.1 - NAD(P)+ transhydrogenase (Si-specific)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenoma
Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt.
Adrenal Insufficiency
Association of adrenal insufficiency with insulin-dependent diabetes mellitus in a patient with inactivating mutations in nicotinamide nucleotide transhydrogenase: a phenocopy of the animal model.
Adrenal Rest Tumor
Combined adrenal failure and testicular adrenal rest tumor in a patient with nicotinamide nucleotide transhydrogenase deficiency.
Adrenocortical Carcinoma
Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma.
Atherosclerosis
Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J Mice Exacerbates Experimental Atherosclerosis.
Bacteremia
Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection.
Breast Neoplasms
Transcription Levels of nicotinamide nucleotide transhydrogenase and Its Antisense in Breast Cancer Samples.
Carcinoma
NNT in NSCLC: No need to worry?
Carcinoma, Hepatocellular
Nicotinamide nucleotide transhydrogenase acts as a new prognosis biomarker in hepatocellular carcinoma.
Pyridine-adenine dinucleotide transhydrogenase activity in cells cultured from rat hepatoma.
Carcinoma, Non-Small-Cell Lung
LncRNA NNT-AS1 promotes lung squamous cell carcinoma progression by regulating the miR-22/FOXM1 axis.
Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function.
NNT in NSCLC: No need to worry?
Cardiomyopathies
Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not.
Cystinosis
Enzymic reduction of cystine and glutathione in cultivated human fibroblast from normal subjects and patients with cystinosis.
Diabetes Mellitus, Type 1
Association of adrenal insufficiency with insulin-dependent diabetes mellitus in a patient with inactivating mutations in nicotinamide nucleotide transhydrogenase: a phenocopy of the animal model.
Glucose Intolerance
A High-Throughput Assay for Modulators of NNT Activity in Permeabilized Yeast Cells.
Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice.
Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice.
Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2.
K(ATP) channels and insulin secretion: a key role in health and disease.
Mitochondrial transhydrogenase--a key enzyme in insulin secretion and, potentially, diabetes.
Nicotinamide nucleotide transhydrogenase mRNA expression is related to human obesity.
Obesity and Type 2 Diabetes: Slow Down! - Can Metabolic Deceleration Protect The Islet Beta Cell From Excess Nutrient-Induced Damage?
Heart Failure
Mitochondrial Bioenergetics and Dysfunction in Failing Heart.
Hypertension
Nicotinamide nucleotide transhydrogenase activity impacts mitochondrial redox balance and the development of hypertension in mice.
Hypothyroidism
Nicotinamide nucleotide transhydrogenase mutation analysis in Chinese patients with thyroid dysgenesis.
Infections
Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection.
Liver Neoplasms, Experimental
Comparison of transhydrogenase and pyridine nucleotide-cytochrome c reductase activities in rat liver and Novikoff hepatoma.
Lung Neoplasms
LncRNA NNT-AS1 promotes lung squamous cell carcinoma progression by regulating the miR-22/FOXM1 axis.
LncRNA NNT-AS1 regulates the progression of lung cancer through the NNT-AS1/miR-3666/E2F2 axis.
Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function.
Malaria
NAD(P) transhydrogenase has vital non-mitochondrial functions in malaria parasite transmission.
Metabolic Diseases
A Direct Comparison of Metabolic Responses to High Fat Diet in C57BL/6J and C57BL/6NJ Mice.
Multiple Sclerosis
Nicotinamide nucleotide transhydrogenase expression analysis in multiple sclerosis patients.
nad(p)+ transhydrogenase (si-specific) deficiency
Combined adrenal failure and testicular adrenal rest tumor in a patient with nicotinamide nucleotide transhydrogenase deficiency.
nad(p)h oxidase (h2o2-forming) deficiency
Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema.
Neoplasms
Combined adrenal failure and testicular adrenal rest tumor in a patient with nicotinamide nucleotide transhydrogenase deficiency.
Long non-coding RNA NNT-AS1 functions as an oncogenic gene through modulating miR-485/BCL9 in cholangiocarcinoma.
Long noncoding RNA NNT-AS1 enhances the malignant phenotype of bladder cancer by acting as a competing endogenous RNA on microRNA-496 thereby increasing HMGB1 expression.
Mammalian NADH:ubiquinone oxidoreductase (Complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of H?O?--implications for their role in disease, especially cancer.
Nicotinamide nucleotide transhydrogenase acts as a new prognosis biomarker in hepatocellular carcinoma.
NNT-induced tumor cell "slimming" reverses the pro-carcinogenesis effect of HIF2a in tumors.
Serum long non?coding RNA NNT?AS1 protected by exosome is a potential biomarker and functions as an oncogene via the miR?496/RAP2C axis in colorectal cancer.
Studies on the isocitrate dehydrogenase. II. Isocitrate dehydrogenase and transhydrogenase in tumor bearing rat liver and ascites tumor cells.
Upregulated expression of LncRNA nicotinamide nucleotide transhydrogenase antisense RNA 1 is correlated with unfavorable clinical outcomes in cancers.
[Occurrence of pyridine nucleotide transhydrogenase in mitochondria of various ascites tumors]
Obesity
Adipose tissue metabolism and inflammation are differently affected by weight loss in obese mice due to either a high-fat diet restriction or change to a low-fat diet.
Alterations of Pancreatic Islet Structure, Metabolism and Gene Expression in Diet-Induced Obese C57BL/6J Mice.
Diet-induced Obesity in Two C57BL/6 Substrains With Intact or Mutant Nicotinamide Nucleotide Transhydrogenase (Nnt) Gene.
Nicotinamide Nucleotide Transhydrogenase (Nnt) is Related to Obesity in Mice.
Nicotinamide nucleotide transhydrogenase mRNA expression is related to human obesity.
Obesity and Type 2 Diabetes: Slow Down! - Can Metabolic Deceleration Protect The Islet Beta Cell From Excess Nutrient-Induced Damage?
Osteosarcoma
Upregulation of long non-coding RNA NNT-AS1 promotes osteosarcoma progression by inhibiting the tumor suppressive miR-320a.
Pneumonia
Evidence for a nicotinamide nucleotide transhydrogenase in Klebsiella pneumoniae.
Stomach Neoplasms
Downregulation of nicotinamide nucleotide transhydrogenase and its naturally occurring antisense RNA in gastric cancer.
Nicotinamide nucleotide transhydrogenase-mediated redox homeostasis promotes tumor growth and metastasis in gastric cancer.
Thyroid Cancer, Papillary
Silencing long non-coding RNAs nicotinamide nucleotide transhydrogenase antisense RNA 1 inhibited papillary thyroid cancer cell proliferation, migration and invasion and promoted apoptosis via targeting miR-199a-5p.
Thyroid Dysgenesis
Nicotinamide nucleotide transhydrogenase mutation analysis in Chinese patients with thyroid dysgenesis.
Tics
Upregulation of mitochondrial NAD(+) levels impairs the clonogenicity of SSEA1(+) glioblastoma tumor-initiating cells.
Tuberculosis
A hybrid of the transhydrogenases from Rhodospirillum rubrum and Mycobacterium tuberculosis catalyses rapid hydride transfer but not the complete, proton-translocating reaction.
Isolation of a 43 kDa protein from Mycobacterium tuberculosis H37Rv and its identification as a pyridine nucleotide transhydrogenase.
Membrane and membrane-associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies.
Similarities between alanine dehydrogenase and the N-terminal part of pyridine nucleotide transhydrogenase and their possible implication in the virulence mechanism of Mycobacterium tuberculosis.