Reference on EC 1.6.2.2 - cytochrome-b5 reductase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kitajima, S.; Yasukochi, Y.; Minakami, S.
Purification and properties of human erythrocyte membrane NADH-cytochrome b5 reductase
Arch. Biochem. Biophys.
210
330-339
1981
Homo sapiens
Bonomi, F.; Long, R.C.; Kurtz, D.M.
Purification and properties of a membrane-bound NADH-cytochrome-b5 reductase from erythrocytes of the sipunculid worm, Phascolopsis gouldii
Biochim. Biophys. Acta
999
147-156
1989
Phascolopsis gouldii
Rigby, J.S.; Bull, P.C.; Ashworth, A.; Shephard, E.A.; Santisteban, I.; Phillips, I.R.
Isolation and characterization of genes coding for cytochrome b5 and cytochrome-b5 reductase
Biochem. Soc. Trans.
17
194-195
1989
Homo sapiens
-
Palmieri, D.A.; Rangachari, A.; Butterfield, D.A.
Effects of domain-specific erythrocyte membrane modulators on acetylcholinesterase and NADH:cytochrome b5 reductase activities
Arch. Biochem. Biophys.
280
224-228
1990
Homo sapiens
Tamura, M.; Yoshida, S.; Tamura, T.; Saitoh, T.; Takeshita, M.
Effect of divalent cations on NADH-dependent and NADPH-dependent cytochrome b5 reduction by hepatic microsomes
Arch. Biochem. Biophys.
280
313-319
1990
Sus scrofa
Borgese, N.; Longhi, R.
Both the outer mitochondrial membrane and the microsomal forms of cytochrome b5 reductase contain covalently bound myristic acid. Quantitative analysis on the polyvinylidene difluoride-immobilized proteins
Biochem. J.
266
341-347
1990
Rattus norvegicus
Shirabe, K.; Yubisui, T.; Takeshita, M.
Expression of human erythrocyte NADH-cytochrome b5 reductase as an alpha-thrombin-cleavable fused protein in Escherichia coli
Biochim. Biophys. Acta
1008
189-192
1989
Homo sapiens
Murakami, K.; Yubisui, T.; Takeshita, M.; Miyata, T.
The NH2-terminal structures of human and rat liver microsomal NADH-cytochrome b5 reductases
J. Biochem.
105
312-317
1989
Homo sapiens
Tamura, M.; Yubisui, T.; Takeshita, M.
The opposite effect of bivalent cations on cytochrome b5 reduction by NADH:cytochrome b5 reductase and NADPH:cytochrome c reductase
Biochem. J.
251
711-715
1988
Bos taurus
Utecht, R.E.; Kurtz, D.M.
Cytochrome b5 and NADH-cytochrome-b5 reductase from sipunculan erythrocytes; a methemerythrin reduction system from Phascolopsis gouldii
Biochim. Biophys. Acta
953
164-178
1988
Phascolopsis gouldii
Takano, T.; Ogawa, K.; Sato, M.; Bando, S.; Yubisui, T.
Preliminary X-ray data of NADH-cytochrome b5 reductase from human erythrocytes
J. Mol. Biol.
195
749-750
1987
Oryctolagus cuniculus, Homo sapiens
Miki, K.; Kaida, S.; Kasai, N.; Iyanagi, T.; Kobayashi, K.; Hayashi, K.
Crystallization and preliminary x-ray crystallographic study of NADH-cytochrome b5 reductase from pig liver microsomes
J. Biol. Chem.
262
11801-11802
1987
Sus scrofa
Jollie, D.R.; Sligar, S.G.; Schuler, M.
Purification and characterization of microsomal cytochrome b5 and NADH cytochrome b5 reductase from Pisum sativum
Plant Physiol.
85
457-462
1987
Pisum sativum
Galle, A.M.; Kader, J.C.
High performance liquid chromatography of plant membrane proteins. NADH-cytochrome b5 reductase as a model
J. Chromatogr.
366
422-426
1986
Solanum tuberosum, Zea mays
-
Borgese, N.; Pietrini, G.
Distribution of the integral membrane protein NADH-cytochrome b5 reductase in rat liver cells, studied with a quantitative radioimmunoblotting assay
Biochem. J.
239
393-403
1986
Rattus norvegicus
Kensil, C.R.; Strittmatter, P.
Binding and fluorescence properties of the membrane domain of NADH-cytochrome-b5 reductase. Determination of the depth of Trp-16 in the bilayer
J. Biol. Chem.
261
7316-7321
1986
Bos taurus
Tamura, M.; Yubisui, T.; Takeshita, M.
The inhibitory effect of halides and carboxylates on hepatic NADH: cytochrome b5 oxidoreductase
Biochem. J.
230
273-276
1985
Bos taurus
Tauber, A.I.; Wright, J.; Higson, F.K.; Edelman, S.A.; Waxman, D.J.
Purification and characterization of the human neutrophil NADH-cytochrome b5 reductase
Blood
66
673-678
1985
Homo sapiens
Golf, S.W.; Graf, V.; Rempeters, G.; Mersdorf, S.
Properties and biochemical characterization of NADH 5alpha-reductase from rat liver microsomes
Biol. Chem. Hoppe-Seyler
366
647-653
1985
Rattus norvegicus
Iyanagi, T.; Watanabe, S.; Anan, K.F.
One-electron oxidation-reduction properties of hepatic NADH-cytochrome b5 reductase
Biochemistry
23
1418-1425
1984
Sus scrofa
Kitajima, S.; Minakami, S.
Human NADH-cytochrome b5 reductases: comparison among those of erythrocyte membrane, erythrocyte cytosol, and liver microsomes
J. Biochem.
93
615-620
1983
Homo sapiens
Tamura, M.; Yubisui, T.; Takeshita, M.
Microsomal NADH-cytochrome b5 reductase of bovine brain: purification and properties
J. Biochem.
94
1547-1555
1983
Bos taurus
Kensil, C.R.; Hediger, M.A.; Ozols, J.; Strittmatter, P.
Isolation and partial characterization of the NH2-terminal membrane-binding domain of NADH-cytochrome b5 reductase
J. Biol. Chem.
258
14656-14663
1983
Bos taurus
Badwey, J.A.; Tauber, A.I.; Karnovsky, M.L.
Properties of NADH-cytochrome-b5 reductase from human neutrophils
Blood
62
152-157
1983
Homo sapiens
Borgese, N.; Macconi, D.; Parola, L.; Pietrini, G.
Rat erythrocyte NADH-cytochrome b5 reductase. Quantitation and comparison between the membrane-bound and soluble forms using an antibody against the rat liver enzyme
J. Biol. Chem.
257
13854-13861
1982
Rattus norvegicus
Yubisui, T.; Takeshita, M.
Purification and properties of soluble NADH-cytochrome b5 reductase of rabbit erythrocytes
J. Biochem.
91
1467-1477
1982
Oryctolagus cuniculus
Fukushima, H.; Umeki, S.; Watanabe, T.; Nozawa, Y.
Purification and partial characterization of cytochrome b5 from Tetrahymena pyriformis
Biochem. Biophys. Res. Commun.
105
502-508
1982
Tetrahymena pyriformis
Schafer, D.A.; Hultquist, D.E.
Purification of bovine liver microsomal NADH-cytochrome b5 reductase using affinity chromatography
Biochem. Biophys. Res. Commun.
95
381-387
1980
Bos taurus
Yubisui, T.; Takeshita, M.
Characterization of the purified NADH-cytochrome b5 reductase of human erythrocytes as a FAD-containing enzyme
J. Biol. Chem.
255
2454-2456
1980
Homo sapiens
Tajima, S.; Mihara, K.; Sato, R.
Two-domain structure of microsomal reduced nicotinamide adenine dinucleotide-cytochrome b5 reductase
Arch. Biochem. Biophys.
198
137-144
1979
Oryctolagus cuniculus
Mihara, K.; Sato, R.; Sakakibara, R.; Wada, H.
Reduced nicotinamide adenine dinucleotide-cytochrome b5 reductase: location of the hydrophobic, membrane-binding region at the carboxyl-terminal end and the masked amino terminus
Biochemistry
17
2829-2834
1978
Oryctolagus cuniculus
-
Hultquist, D.E.
Methemoglobin reduction system of erythrocytes
Methods Enzymol.
52
463-473
1978
Homo sapiens
Mihara, K.; Sato, R.
Detergent-solubilized NADH-cytochrome b5 reductase
Methods Enzymol.
52
102-108
1978
Oryctolagus cuniculus
Lostanlen, D.; De Barro, A.V.; Leroux, A.; Kaplan, J.C.
Soluble NADH-cytochrome b5 reductase from rabbit liver cytosol: partial purification and characterization
Biochim. Biophys. Acta
526
42-51
1978
Oryctolagus cuniculus
Kubota, S.; Yoshida, Y.; Kumaoka, H.
Studies on the microsomal electron-transport system of anaerobically grown yeast. IV. Purification and characterization of NADH-cytochrome b5 reductase
J. Biochem.
81
187-195
1977
Saccharomyces cerevisiae
Mihara, K.; Sato, R.
Purification and properties of the intact form of NADH-cytochrome b5 reductase from rabbit liver microsomes
J. Biochem.
78
1057-1073
1975
Oryctolagus cuniculus
Takesue, S.; Omura, T.
Purification and properties of NADH-cytochrome b5 reductase solubilized by lysosomes from rat liver microsomes
J. Biochem.
67
267-276
1970
Rattus norvegicus
Strittmatter, P.
Microsomal cytochrome b5 and cytochrome b5 reductase
The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbck, K. , eds. )
8
113-145
1963
Bos taurus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
-
Oshino, N.; Sato, R.
Stimulation by phenols of the reoxidation microsomal bound cytochrome b5 and its implication to fatty acid desaturation
J. Biochem.
69
169-180
1971
Rattus norvegicus, Sus scrofa
Ortiz de Montellano, P.R.
Cytochrome P450-Structure, Mechanism and Biochemistry
Cytochrome P450. Structure, Mechanism Biochem. (Ortiz de Montellano, P. R. ed. ) Plenum Press, New York
1986
Homo sapiens
-
Hultquist, D.E.; Passon, P.G.
Catalysis of methaemoglobin reduction by erythrocyte cytochrome b5 and cytochrome b5 reductase
Nat. New Biol.
229
252-254
1971
Homo sapiens
Kader, J.C.
Cyanide sensitivity and induction of the microsomal oleoyl-CoA desaturase of potato tuber
Biochim. Biophys. Acta
486
429-436
1977
Solanum tuberosum
Yubisui, T.; Naitoh, Y.; Zenno, S.; Tamura, M.; Takeshita, M.; Sakaki, Y.
Molecular cloning of cDNAs of human liver and placenta NADH-cytochrome b5 reductase
Proc. Natl. Acad. Sci. USA
84
3609-3613
1987
Homo sapiens
Fujimoto, Y.; Shirabe, K.; Nagai, T.; Yubisui, T.; Takeshita, M.
Role of Lys-110 of human NADH-cytochrome b5 reductase in NADH binding as probed by site-directed mutagenesis
FEBS Lett.
322
30-32
1993
Homo sapiens
Mota Vieira, L.; Kaplan, J.C.; Kahn, A.; Leroux, A.
Heterogeneity of the rat NADH-cytochrome-b5-reductase transcripts resulting from multiple alternative first exons
Eur. J. Biochem.
220
729-737
1994
Homo sapiens, Rattus norvegicus
Yang, M.X.; Cederbaum, A.I.
Fractionation of liver microsomes with polyethylene glycol and purification of NADH-cytochrome b5 oxidoreductase and cytochrome b5
Arch. Biochem. Biophys.
315
438-444
1994
Oryctolagus cuniculus, Rattus norvegicus
Saido, H.; Watanabe, F.; Tamura, Y.; Miyatake, K.; Ito, A.; Yubisui, T.; Nakano, Y.
Cytochrome b5-like hemoprotein/cytochrome b5 reductase complex in rat liver mitochondria has NADH-linked aquacobalamin reductase activity
J. Nutr.
124
1037-1040
1994
Rattus norvegicus
Nishida, H.; Inaka, K.; Yamanaka, M.; Kaida, S.; Kobayashi, K.; Miki, K.
Crystal structure of NADH-cytochrome b5 reductase from pig liver at 2.4 A resolution
Biochemistry
34
2763-2767
1995
Sus scrofa
Miura, A.; Tampo, Y.; Yonaha, M.
The reducing ability of iron chelates by NADH-cytochrome B5 reductase or cytochrome B5 responsible for NADH-supported lipid peroxidation
Biochem. Mol. Biol. Int.
37
141-150
1995
Rattus norvegicus
Kim, C.; Crane, F.L.; Becker, G.W.; Morre, D.J.
Purification of NADH-cytochrome b5 reductase from rat liver plasma membranes
Protoplasma
184
111-117
1995
Rattus norvegicus
-
Barham, H.M.; Inglis, R.; Chinje, E.C.; Stratford, I.J.
Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells
Br. J. Cancer
74
1188-1193
1996
Homo sapiens
Barham, H.M.; Stratford, I.J.
Enzymology of the reduction of the novel fused pyrazine mono-N-oxide bioreductive drug, RB90740 roles for P450 reductase and cytochrome b5 reductase
Biochem. Pharmacol.
51
829-837
1996
Mus musculus
Barber, M.J.; Quinn, G.B.
High-level expression in Escherichia coli of the soluble, catalytic domain of rat hepatic cytochrome b5 reductase
Protein Expr. Purif.
8
41-47
1996
Rattus norvegicus
Nishida, H.; Miki, K.
Electrostatic properties deduced from refined structures of NADH-cytochrome b5 reductase and the other flavin-dependent reductases: pyridine nucleotide-binding and interaction with an electron-transfer partner
Proteins Struct. Funct. Genet.
26
32-41
1996
Sus scrofa
Zhang, M.; Scott, J.G.
Purification and characterization of cytochrome b5 reductase from the house fly, Musca domestica
Comp. Biochem. Physiol. B
113
175-183
1996
Musca domestica
Yang, M.X.; Cederbaum, A.I.
Interaction of ferric complexes with NADH-cytochrome b5 reductase and cytochrome b5: lipid peroxidation, H2O2 generation, and ferric reduction
Arch. Biochem. Biophys.
331
69-78
1996
Rattus norvegicus
Kawano, M.; Shirabe, K.; Nagai, T.; Takeshita, M.
Role of carboxyl residues surrounding heme of human cytochrome b5 in the electrostatic interaction with NADH-cytochrome b5 reductase
Biochem. Biophys. Res. Commun.
245
666-669
1998
Homo sapiens
Lee, J.Y.; Kim, Y.H.; Lee, S.J.
Purification and comparison of NADH-cytochrome b5 reductase from mitochondrial outer membrane of bovine heart and turnip
Bull. Chem. Soc. Kor.
19
160-164
1998
Bos taurus, Brassica napus
-
Lamb, D.C.; Kelly, D.E.; Manning, N.J.; Kaderbhai, M.A.; Kelly, S.L.
Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction
FEBS Lett.
462
283-288
1999
Saccharomyces cerevisiae
Kimura, S.; Emi, Y.; Ikushiro, S.; Iyanagi, T.
Systematic mutations of highly conserved His49 and carboxyl-terminal of recombinant porcine liver NADH-cytochrome b5 reductase solubilized domain
Biochim. Biophys. Acta
1430
290-301
1999
Sus scrofa
Arinc, E.; Cakir, D.
Simultaneous purification and characterization of cytochrome b5 reductase and cytochrome b5 from sheep liver
Int. J. Biochem. Cell Biol.
31
345-362
1999
Ovis aries
Bagnaresi, P.; Thoiron, S.; Mansion, M.; Rossignol, M.; Pupillo, P.; Briat, J.F.
Cloning and characterization of a maize cytochrome-b5 reductase with Fe3+-chelate reduction capability
Biochem. J.
338
499-505
1999
Zea mays (Q9ZPN0), Zea mays
Bagnaresi, P.; Mazars-Marty, D.; Pupilld, P.; Marty, F.; Briat, J.F.
Tonoplast subcellular localization of maize cytochrome b5 reductases
Plant J.
24
645-654
2000
Zea mays (Q8W2K4)
Bewley, M.C.; Marohnic, C.C.; Barber, M.J.
The structure and biochemistry of NADH-dependent cytochrome b5 reductase are now consistent
Biochemistry
40
13574-13582
2001
Rattus norvegicus (P20070)
Kimura, S.; Nishida, H.; Iyanagi, T.
Effects of flavin-binding motif amino acid mutations in the NADH-cytochrome b5 reductase catalytic domain on protein stability and catalysis
J. Biochem.
130
481-490
2001
Sus scrofa
Davis, C.A.; Dhawan, I.K.; Johnson, M.K.; Barber, M.J.
Heterologous expression of an endogenous rat cytochrome b5/cytochrome b5 reductase fusion protein: Identification of histidines 62 and 85 as the heme axial ligands
Arch. Biochem. Biophys.
400
63-75
2002
Rattus norvegicus
Bando, S.; Takano, T.; Yubisui, T.; Shirabe, K.; Takeshita, M.; Nakagawa, A.
Structure of human erythrocyte NADH-cytochrome b5 reductase
Acta Crystallogr. Sect. D
60
1929-1934
2004
Homo sapiens
Mokashi, V.; Li, L.; Porter, T.D.
Cytochrome b5 reductase and cytochrome b5 support the CYP2E1-mediated activation of nitrosamines in a recombinant Ames test
Arch. Biochem. Biophys.
412
147-152
2003
Homo sapiens
Davis, C.A.; Crowley, L.J.; Barber, M.J.
Cytochrome b5 reductase: the roles of the recessive congenital methemoglobinemia mutants P144L, L148P, and R159*
Arch. Biochem. Biophys.
431
233-244
2004
Rattus norvegicus (P20070)
Marohnic, C.C.; Bewley, M.C.; Barber, M.J.
Engineering and characterization of a NADPH-utilizing cytochrome b5 reductase
Biochemistry
42
11170-11182
2003
Rattus norvegicus (P20070)
Bewley, M.C.; Davis, C.A.; Marohnic, C.C.; Taormina, D.; Barber, M.J.
The structure of the S127P mutant of cytochrome b5 reductase that causes methemoglobinemia shows the AMP moiety of the flavin occupying the substrate binding site
Biochemistry
42
13145-13151
2003
Rattus norvegicus
Baker, M.A.; Krutskikh, A.; Curry, B.J.; Hetherington, L.; Aitken, R.J.
Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa
Biol. Reprod.
73
334-42
2005
Homo sapiens (Q6BCY4), Homo sapiens
Curry, B.J.; Roman, S.D.; Wallace, C.A.; Scott, R.; Miriami, E.; Aitken, R.J.
Identification and characterization of a novel splice variant of mouse and rat cytochrome b5/cytochrome b5 reductase
Genomics
83
425-438
2004
Mus musculus (Q3TDX8), Mus musculus, Rattus norvegicus (Q68EJ0)
Bello, R.I.; Alcain, F.J.; Gomez-Diaz, C.; Lopez-Lluch, G.; Navas, P.; Villalba, J.M.
Hydrogen peroxide- and cell-density-regulated expression of NADH-cytochrome b5 reductase in HeLa cells
J. Bioenerg. Biomembr.
35
169-179
2003
Homo sapiens
Kimura, S.; Kawamura, M.; Iyanagi, T.
Role of Thr(66) in porcine NADH-cytochrome b5 reductase in catalysis and control of the rate-limiting step in electron transfer
J. Biol. Chem.
278
3580-3589
2003
Sus scrofa (P83686), Sus scrofa
Kurian, J.R.; Bajad, S.U.; Miller, J.L.; Chin, N.A.; Trepanier, L.A.
NADH cytochrome b5 reductase and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans
J. Pharmacol. Exp. Ther.
311
1171-1178
2004
Homo sapiens
Percy, M.J.; Crowley, L.J.; Boudreaux, J.; Barber, M.J.
Expression of a novel P275L variant of NADH:cytochrome b5 reductase gives functional insight into the conserved motif important for pyridine nucleotide binding
Arch. Biochem. Biophys.
447
59-67
2006
Homo sapiens (P00387), Homo sapiens
Roma, G.W.; Crowley, L.J.; Barber, M.J.
Expression and characterization of a functional canine variant of cytochrome b5 reductase
Arch. Biochem. Biophys.
452
69-82
2006
Canis lupus familiaris
Roma, G.W.; Crowley, L.J.; Davis, C.A.; Barber, M.J.
Mutagenesis of glycine 179 modulates both catalytic efficiency and reduced pyridine nucleotide specificity in cytochrome b5 reductase
Biochemistry
44
13467-13476
2005
Rattus norvegicus (P20070)
Marohnic, C.C.; Crowley, L.J.; Davis, C.A.; Smith, E.T.; Barber, M.J.
Cytochrome b5 reductase: role of the si-face residues, proline 92 and tyrosine 93, in structure and catalysis
Biochemistry
44
2449-2461
2005
Rattus norvegicus (P20070)
Tonegawa, Y.; Umeda, N.; Hayakawa, T.; Ishibashi, T.
Evaluation of data in terms of two-dimensional random walk model: interaction between NADH-cytochrome b5 reductase and cytochrome b5
Biomed. Res.
26
207-212
2005
Rattus norvegicus
Percy, M.J.; Crowley, L.J.; Roper, D.; Vulliamy, T.J.; Layton, D.M.; Barber, M.J.
Identification and characterization of the novel FAD-binding lobe G75S mutation in cytochrome b(5) reductase: an aid to determine recessive congenital methemoglobinemia status in an infant
Blood Cells Mol. Dis.
36
81-90
2006
Homo sapiens
Percy, M.J.; Crowley, L.J.; Davis, C.A.; McMullin, M.F.; Savage, G.; Hughes, J.; McMahon, C.; Quinn, R.J.; Smith, O.; Barber, M.J.; Lappin, T.R.
Recessive congenital methaemoglobinaemia: functional characterization of the novel D239G mutation in the NADH-binding lobe of cytochrome b5 reductase
Br. J. Haematol.
129
847-853
2005
Homo sapiens
Kurian, J.R.; Chin, N.A.; Longlais, B.J.; Hayes, K.L.; Trepanier, L.A.
Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5
Chem. Res. Toxicol.
19
1366-1373
2006
Homo sapiens
Saulter, J.Y.; Kurian, J.R.; Trepanier, L.A.; Tidwell, R.R.; Bridges, A.S.; Boykin, D.W.; Stephens, C.E.; Anbazhagan, M.; Hall, J.E.
Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase
Drug Metab. Dispos.
33
1886-1893
2005
Homo sapiens
Colombo, S.; Longhi, R.; Alcaro, S.; Ortuso, F.; Sprocati, T.; Flora, A.; Borgese, N.
N-myristoylation determines dual targeting of mammalian NADH-cytochrome b5 reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning
J. Cell Biol.
168
735-745
2005
Rattus norvegicus
Shockey, J.M.; Dhanoa, P.K.; Dupuy, T.; Chapital, D.C.; Mullen, R.T.; Dyer, J.M.
Cloning, functional analysis, and subcellular localization of two isoforms of NADH:cytochrome b5 reductase from developing seeds of tung (Vernicia fordii)
Plant Sci.
169
375-385
2005
Vernicia fordii, Vernicia fordii (Q5PY86)
Kim, S.; Suga, M.; Ogasahara, K.; Ikegami, T.; Minami, Y.; Yubisui, T.; Tsukihara, T.
Structure of Physarum polycephalum cytochrome b5 reductase at 1.56 A resolution
Acta Crystallogr. Sect. F
F63
274-279
2007
Physarum polycephalum
Ikegami, T.; Kameyama, E.; Yamamoto, S.Y.; Minami, Y.; Yubisui, T.
Structure and properties of the recombinant NADH-cytochrome b5 reductase of Physarum polycephalum
Biosci. Biotechnol. Biochem.
71
783-790
2007
Physarum polycephalum (Q1HA49), Physarum polycephalum
Kedar, P.S.; Warang, P.; Nadkarni, A.H.; Colah, R.B.; Ghosh, K.
A novel G143D mutation in the NADH-cytochrome b5 reductase gene in an Indian patient with type I recessive hereditary methemoglobinemia
Blood Cells Mol. Dis.
40
323-327
2008
Homo sapiens (P00387)
Fermo, E.; Bianchi, P.; Vercellati, C.; Marcello, A.P.; Garatti, M.; Marangoni, O.; Barcellini, W.; Zanella, A.
Recessive hereditary methemoglobinemia: two novel mutations in the NADH-cytochrome b5 reductase gene
Blood Cells Mol. Dis.
41
50-55
2008
Homo sapiens (P00387), Homo sapiens
Percy, M.J.; Lappin, T.R.
Recessive congenital methaemoglobinaemia: cytochrome b(5) reductase deficiency
Br. J. Haematol.
141
298-308
2008
Homo sapiens (P00387), Homo sapiens, Rattus norvegicus (P20070)
Asada, T.; Nagase, S.; Nishimoto, K.; Koseki, S.
Molecular dynamics simulation study on stabilities and reactivities of NADH cytochrome B5 reductase
J. Phys. Chem. B
112
5718-5727
2008
Rattus norvegicus (P20070)
Brankova, L.; Ivanov, S.; Alexieva, V.
The induction of microsomal NADPH:cytochrome P450 and NADH:cytochrome b5 reductases by long-term salt treatment of cotton (Gossypium hirsutum L.) and bean (Phaseolus vulgaris L.) plants
Plant Physiol. Biochem.
45
691-695
2007
Gossypium hirsutum, Phaseolus vulgaris
Yantsevich, A.V.; Gilep, A.A.; Usanov, S.A.
Mechanism of electron transfer in fusion protein cytochrome b5-NADH-cytochrome b5 reductase
Biochemistry (Moscow)
73
1096-1107
2008
Rattus norvegicus
Setayesh, N.; Sepehrizadeh, Z.; Jaberi, E.; Yazdi, M.T.
Cloning, molecular characterization and expression of a cDNA encoding a functional NADH-cytochrome b5 reductase from Mucor racemosus PTCC 5305 in E. coli
Biol. Res.
42
137-146
2009
Mucor racemosus (A8WEG5), Mucor racemosus PTCC 5305 (A8WEG5), Mucor racemosus PTCC 5305
Nishimura, Y.; Shibuya, M.; Muraki, A.; Takeuchi, F.; Park, S.; Tsubaki, M.
Structural and mechanistic roles of three consecutive Pro residues of porcine NADH-cytochrome b5 reductase for the binding of beta-NADH
J. Biosci. Bioeng.
108
286-292
2009
Sus scrofa
Percy, M.J.; Aslan, D.
NADH-cytochrome b5 reductase in a Turkish family with recessive congenital methaemoglobinaemia type I
J. Clin. Pathol.
61
1122-1123
2008
Homo sapiens
Samhan-Arias, A.K.; Garcia-Bereguiain, M.A.; Martin-Romero, F.J.; Gutierrez-Merino, C.
Clustering of plasma membrane-bound cytochrome b5 reductase within lipid raft microdomains of the neuronal plasma membrane
Mol. Cell. Neurosci.
40
14-26
2009
Rattus norvegicus (P20070)
Mirzaei, S.A.; Yazdi, M.T.; Sepehrizadeh, Z.
Secretory expression and purification of a soluble NADH cytochrome b5 reductase enzyme from Mucor racemosus in Pichia pastoris based on codon usage adaptation
Biotechnol. Lett.
32
1705-1711
2010
Mucor racemosus
Deng, B.; Parthasarathy, S.; Wang, W.; Gibney, B.R.; Battaile, K.P.; Lovell, S.; Benson, D.R.; Zhu, H.
Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain
J. Biol. Chem.
285
30181-30191
2010
Homo sapiens (Q7L1T6), Homo sapiens
Marques-da-Silva, D.; Samhan-Arias, A.K.; Tiago, T.; Gutierrez-Merino, C.
L-type calcium channels and cytochrome b5 reductase are components of protein complexes tightly associated with lipid rafts microdomains of the neuronal plasma membrane
J. Proteomics
73
1502-1510
2010
Rattus norvegicus
Arikoglu, T.; Yarali, N.; Kara, A.; Bay, A.; Bozkaya, I.O.; Tunc, B.; Percy, M.J.
A novel L218P mutation in NADH-cytochrome b5 reductase associated with type I recessive congenital methemoglobinemia
Pediatr. Hematol. Oncol.
26
381-385
2009
Homo sapiens
Siddique, Y.; Ara, G.; Gupta, J.; Beg, T.; Afzal, M.
Estimation of cytochrome b5 reductase activity in red blood cells of Rattus norvegicus after the treatment of trichloroacetic acid
Pharmacologyonline
3
986-990
2009
Rattus norvegicus
-
Celik, H.; Ko?ar, M.
Inhibitory effects of dietary flavonoids on purified hepatic NADH-cytochrome b5 reductase: structure-activity relationships
Chem. Biol. Interact.
197
103-109
2012
Bos taurus
Elahian, F.; Sepehrizadeh, Z.; Moghimi, B.; Mirzaei, S.A.
Human cytochrome b5 reductase: structure, function, and potential applications
Crit. Rev. Biotechnol.
2012
1-11
2012
Homo sapiens
Saleh, M.C.; McConkey, S.
NADH-dependent cytochrome b5 reductase and NADPH methemoglobin reductase activity in the erythrocytes of Oncorhynchus mykiss
Fish Physiol. Biochem.
38
1807-1813
2012
Canis lupus familiaris, Equus caballus, Felis sp., Oncorhynchus mykiss
McConkey, S.; Saunders, J.; Speare, D.J.
Comparison of NADH-dependent cytochrome b5 reductase activity and in vitro methemoglobin induction by sodium nitrite in Oncorhynchus mykiss, Salmo salar, and Salvelinus fontinalis
Fish Physiol. Biochem.
39
713-719
2013
Oncorhynchus mykiss, Salmo salar, Salvelinus fontinalis
Yamada, M.; Tamada, T.; Takeda, K.; Matsumoto, F.; Ohno, H.; Kosugi, M.; Takaba, K.; Shoyama, Y.; Kimura, S.; Kuroki, R.; Miki, K.
Elucidations of the catalytic cycle of NADH-cytochrome b5 reductase by X-ray crystallography: new insights into regulation of efficient electron transfer
J. Mol. Biol.
425
4295-4306
2013
Sus scrofa (P83686), Sus scrofa
Wayne, L.L.; Wallis, J.G.; Kumar, R.; Markham, J.E.; Browse, J.
Cytochrome b5 reductase encoded by CBR1 is essential for a functional male gametophyte in Arabidopsis
Plant Cell
25
3052-3066
2013
Arabidopsis thaliana
Celik, H.; Kosar, M.; Arinc, E.
In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase
Toxicology
308
34-40
2013
Bos taurus
Celik, H.; Arinc, E.
Evaluation of bioreductive activation of anticancer drugs idarubicin and mitomycin C by NADH-cytochrome b5 reductase and cytochrome P450 2B4
Xenobiotica
43
263-275
2013
Bos taurus
Rawa, K.; Chelmecka-Hanusiewicz, L.; Plochocka, D.; Pawinska-Wasikowska, K.; Balwierz, W.; Burzynska, B.
Characterization of a novel mutation in the NADH-cytochrome b5 reductase gene responsible for rare hereditary methaemoglobinaemia type I
Acta Haematol.
130
122-125
2013
Homo sapiens
Hyun, D.; Lee, G.
Cytochrome b5 reductase, a plasma membrane redox enzyme, protects neuronal cells against metabolic and oxidative stress through maintaining redox state and bioenergetics
Age (Dordr)
37
122
2015
Homo sapiens
Amdahl, M.B.; Sparacino-Watkins, C.E.; Corti, P.; Gladwin, M.T.; Tejero, J.
Efficient reduction of vertebrate cytoglobins by the cytochrome b5/cytochrome b5 reductase/NADH system
Biochemistry
56
3993-4004
2017
Homo sapiens (P00387), Homo sapiens
Zhang, Y.; Wang, H.; Zhang, J.; Hu, Y.; Zhang, L.; Wu, X.; Su, X.; Li, T.; Zou, X.; Liang, B.
The cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans
Biochim. Biophys. Acta
1861
310-319
2016
Caenorhabditis elegans
Oikawa, K.; Odero, G.L.; Nafez, S.; Ge, N.; Zhang, D.; Kobayashi, H.; Sate, K.; Kimura, S.; Tateno, M.; Albensi, B.C.
Visinin-like protein-3 modulates the interaction between cytochrome b 5 and NADH-cytochrome b 5 reductase in a Ca(2+)-dependent manner
Cell Biochem. Biophys.
74
449-457
2016
Mus musculus
Stiborova, M.; Indra, R.; Moserova, M.; Frei, E.; Schmeiser, H.H.; Kopka, K.; Philips, D.H.; Arlt, V.M.
NADH cytochrome b5 reductase and cytochrome b5 can act as sole electron donors to human cytochrome P450 1A1-mediated oxidation and DNA adduct formation by benzo[a]pyrene
Chem. Res. Toxicol.
29
1325-1334
2016
Rattus norvegicus
Ming, H.; Lan, Y.; He, F.; Xiao, X.; Zhou, X.; Zhang, Z.; Li, P.; Huang, G.
Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis
Chin. J. Cancer
34
459-467
2015
Homo sapiens
Rahaman, M.M.; Nguyen, A.T.; Miller, M.P.; Hahn, S.A.; Sparacino-Watkins, C.; Jobbagy, S.; Carew, N.T.; Cantu-Medellin, N.; Wood, K.C.; Baty, C.J.; Schopfer, F.J.; Kelley, E.E.; Gladwin, M.T.; Martin, E.; Straub, A.C.
Cytochrome b5 reductase 3 modulates soluble guanylate cyclase redox state and cGMP signaling
Circ. Res.
121
137-148
2017
Rattus norvegicus
Maeda, S.; Kobori, H.; Tanigawa, M.; Sato, K.; Yubisui, T.; Hori, H.; Nagata, Y.
Methemoglobin reduction by NADH-cytochrome b(5) reductase in Propsilocerus akamusi larvae
Comp. Biochem. Physiol. B
185
54-61
2015
Propsilocerus akamusi
Elahian, F.; Sepehrizadeh, Z.; Moghimi, B.; Mirzaei, S.
Human cytochrome b5 reductase Structure, function, and potential applications
Crit. Rev. Biotechnol.
34
134-143
2014
Homo sapiens, Arabidopsis thaliana (A0A178US77), Bos taurus (P07514)
-
Plitzko, B.; Havemeyer, A.; Bork, B.; Bittner, F.; Mendel, R.; Clement, B.
Defining the role of the NADH-cytochrome-b5 reductase 3 in the mitochondrial amidoxime reducing component enzyme system
Drug Metab. Dispos.
44
1617-1621
2016
Homo sapiens
Zambo, V.; Toth, M.; Schlachter, K.; Szelenyi, P.; Sarnyai, F.; Lotz, G.; Csala, M.; Kereszturi, E.
Cytosolic localization of NADH cytochrome b5 oxidoreductase (Ncb5or)
FEBS Lett.
590
661-671
2016
Homo sapiens (Q7L1T6)
Samhan-Arias, A.K.; Gutierrez-Merino, C.
Purified NADH-cytochrome b5 reductase is a novel superoxide anion source inhibited by apocynin sensitivity to nitric oxide and peroxynitrite
Free Radic. Biol. Med.
73
174-189
2014
Sus scrofa
Nikiforova, A.B.; Saris, N.E.; Kruglov, A.G.
External mitochondrial NADH-dependent reductase of redox cyclers VDAC1 or Cyb5R3?
Free Radic. Biol. Med.
74
74-84
2014
Rattus norvegicus
Derbyshire, M.C.; Michaelson, L.; Parker, J.; Kelly, S.; Thacker, U.; Powers, S.J.; Bailey, A.; Hammond-Kosack, K.; Courbot, M.; Rudd, J.
Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence
Fungal Genet. Biol.
82
69-84
2015
Zymoseptoria tritici (F9X691), Zymoseptoria tritici CBS 115943 (F9X691)
Rahaman, M.M.; Reinders, F.G.; Koes, D.; Nguyen, A.T.; Mutchler, S.M.; Sparacino-Watkins, C.; Alvarez, R.A.; Miller, M.P.; Cheng, D.; Chen, B.B.; Jackson, E.K.; Camacho, C.J.; Straub, A.C.
Structure guided chemical modifications of propylthiouracil reveal novel small molecule inhibitors of cytochrome b5 reductase 3 that increase nitric oxide bioavailability
J. Biol. Chem.
290
16861-16872
2015
Homo sapiens (P00387)
Kollipara, S.; Tatireddy, S.; Pathirathne, T.; Rathnayake, L.K.; Northrup, S.H.
Contribution of electrostatics to the kinetics of electron transfer from NADH-cytochrome b5 reductase to Fe(III)-cytochrome b5
J. Phys. Chem. B
120
8193-8207
2016
Rattus norvegicus
Lund, R.R.; Leth-Larsen, R.; Caterino, T.D.; Terp, M.G.; Nissen, J.; Laenkholm, A.V.; Jensen, O.N.; Ditzel, H.J.
NADH-cytochrome b5 reductase 3 promotes colonization and metastasis formation and is a prognostic marker of disease-free and overall survival in estrogen receptor-negative breast cancer
Mol. Cell. Proteomics
14
2988-2999
2015
Homo sapiens (P00387), Homo sapiens
Henderson, C.J.; McLaughlin, L.A.; Wolf, C.R.
Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system
Mol. Pharmacol.
83
1209-1217
2013
Mus musculus
Martin-Montalvo, A.; Sun, Y.; Diaz-Ruiz, A.; Ali, A.; Gutierrez, V.; Palacios, H.H.; Curtis, J.; Siendones, E.; Ariza, J.; Abulwerdi, G.A.; Sun, X.; Wang, A.X.; Pearson, K.J.; Fishbein, K.W.; Spencer, R.G.; Wang, M.; Han, X.; Scheibye-Knudsen, M.; Baur, J.A.; Shertzer, H.G.; Navas, P.; Villalba, J.M.; Zou, S.
Cytochrome b5 reductase and the control of lipid metabolism and healthspan
NPJ Aging Mechan. Dis.
2
16006
2016
Drosophila melanogaster
Gutierrez, M.S.; Rojas, M.C.; Sepulveda, D.; Baeza, M.; Cifuentes, V.; Alcaino, J.
Molecular characterization and functional analysis of cytochrome b5 reductase (CBR) encoding genes from the carotenogenic yeast Xanthophyllomyces dendrorhous
PLoS ONE
10
e0140424
2015
Phaffia rhodozyma, Phaffia rhodozyma ATCC 96594
Jakobs, H.H.; Mikula, M.; Havemeyer, A.; Strzalkowska, A.; Borowa-Chmielak, M.; Dzwonek, A.; Gajewska, M.; Hennig, E.E.; Ostrowski, J.; Clement, B.
The N-reductive system composed of mitochondrial amidoxime reducing component (mARC), cytochrome b5 (CYB5B) and cytochrome b5 reductase (CYB5R) is regulated by fasting and high fat diet in mice
PLoS ONE
9
e105371
2014
Mus musculus
Takaba, K.; Takeda, K.; Kosugi, M.; Tamada, T.; Miki, K.
Distribution of valence electrons of the flavin cofactor in NADH-cytochrome b5 reductase
Sci. Rep.
7
43162
2017
Sus scrofa (P83686)
Xiao, X.; Zhao, W.; Tian, F.; Zhou, X.; Zhang, J.; Huang, T.; Hou, B.; Du, C.; Wang, S.; Mo, Y.; Yu, N.; Zhou, S.; You, J.; Zhang, Z.; Huang, G.; Zeng, X.
Cytochrome b5 reductase 2 is a novel candidate tumor suppressor gene frequently inactivated by promoter hypermethylation in human nasopharyngeal carcinoma
Tumour Biol.
35
3755-3763
2014
Homo sapiens
Benson, D.; Lovell, S.; Mehzabeen, N.; Galeva, N.; Cooper, A.; Gao, P.; Battaile, K.; Zhu, H.
Crystal structures of the naturally fused CS and cytochrome b5 reductase (b5R) domains of Ncb5or reveal an expanded CS fold, extensive CS-b5R interactions and productive binding of the NAD(P)+ nicotinamide ring
Acta Crystallogr. Sect. D
75
628-638
2019
Homo sapiens (Q7L1T6)
Amdahl, M.B.; Petersen, E.E.; Bocian, K.; Kaliszuk, S.J.; DeMartino, A.W.; Tiwari, S.; Sparacino-Watkins, C.E.; Corti, P.; Rose, J.J.; Gladwin, M.T.; Fago, A.; Tejero, J.
The zebrafish cytochrome b5/cytochrome b5 reductase/NADH system efficiently reduces cytoglobins 1 and 2 conserved activity of cytochrome b5/cytochrome b5 reductases during vertebrate evolution
Biochemistry
58
3212-3223
2019
Danio rerio (Q6NYE6), Danio rerio
Samhan-Arias, A.K.; Almeida, R.M.; Ramos, S.; Cordas, C.M.; Moura, I.; Gutierrez-Merino, C.; Moura, J.J.G.
Topography of human cytochrome b5/cytochrome b5 reductase interacting domain and redox alterations upon complex formation
Biochim. Biophys. Acta Bioenerg.
1859
78-87
2018
Homo sapiens (P00387)
Kedar, P.; Desai, A.; Warang, P.; Colah, R.
A microplate reader-based method to quantify NADH-cytochrome b5 reductase activity for diagnosis of recessive congenital methaemoglobinemia
Hematology
22
252-257
2017
Homo sapiens (P00387)
You, C.; Liu, C.; Li, Y.; Jiang, P.; Ma, Q.
Structural and enzymatic analysis of the cytochrome b5 reductase domain of Ulva prolifera nitrate reductase
Int. J. Biol. Macromol.
111
1175-1182
2018
Ulva prolifera (A0A286R227)
Samhan-Arias, A.K.; Fortalezas, S.; Cordas, C.M.; Moura, I.; Moura, J.J.G.; Gutierrez-Merino, C.
Cytochrome b5 reductase is the component from neuronal synaptic plasma membrane vesicles that generates superoxide anion upon stimulation by cytochrome c
Redox Biol.
15
109-114
2018
Homo sapiens, Rattus norvegicus
html completed
